Long-term effect of SARS-CoV-2 variant : Challenging issues and controlling strategies
This article provides an eradication of the COVID-19 and omicron variant as well as the population who have heart attack after post COVID-19 of these epidemic diseases. Then the existence and uniqueness of global positive solution are studied. Ensuing, In this article, we classify COVID-19 virus and omicron variant which go to extinction and become persistent in mean. By using Lyapunov function, the existence of ergodic stationary distribution are established. Later from the persistent disease as well as extinction, heart disease are ready to develop in the human body. By Eventually, an optimal control strategies are intro...
Source: Gene - May 16, 2024 Category: Genetics & Stem Cells Authors: M Pitchaimani U Aswini Source Type: research

Generation of a new mouse model for Usher syndrome crossing Kunming mice with CBA/J mice
CONCLUSIONS: We successfully introduced the hearing-loss phenotype of inbred mice with USH into CBA/J mice, which provides a good animal model for future studies on the important physiological roles of the Adgrv1 gene in inner-ear structure and for therapeutic studies targeting Adgrv1-mutated USH.PMID:38754567 | DOI:10.1016/j.gene.2024.148562 (Source: Gene)
Source: Gene - May 16, 2024 Category: Genetics & Stem Cells Authors: Shaoheng Li Yihong Jiang Lei Zhang Weiming Yan Dongyu Wei Min Zhang Bin Zhu Tao Chen Xiaocheng Wang Zuoming Zhang Yuting Su Source Type: research

An entropy-based study on the mutational landscape of SARS-CoV-2 in USA: comparing different variants and revealing co-mutational behavior of proteins
Gene. 2024 May 14:148556. doi: 10.1016/j.gene.2024.148556. Online ahead of print.ABSTRACTCOVID-19 emergency has pushed the international scientific community to use every resource to combat the spread of the virus, to understand its biology and predict its possible evolution in terms of new variants. Since the first SARS-CoV-2 virus nucleotide and amino acid sequences were made available, information theory was used to study how viral information content was changing over time and then trace the evolution of its mutational landscape. In this work we analyzed SARS-CoV-2 sequences collected mainly in the USA in a period from...
Source: Gene - May 16, 2024 Category: Genetics & Stem Cells Authors: Daniele Santoni Source Type: research

Investigation of crucial genes and mitochondrial function impairment in diabetic cardiomyopathy
CONCLUSION: Our research defined four crucial genes, as well as determined that mitochondrial function impairment compromises calcium homeostasis ultimately resulting in contractile dysfunction is a central contributor to DCM progression. Hopefully, this study will offer more effective biomarkers for DCM diagnosis and treatment.PMID:38754569 | DOI:10.1016/j.gene.2024.148563 (Source: Gene)
Source: Gene - May 16, 2024 Category: Genetics & Stem Cells Authors: Maierhaba Tuersuntuoheti Lei Zhou Juexing Li Shangneng Yang Suying Zhou Hui Gong Source Type: research

The deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone
This study strongly suggests that the Asb15b gene plays a crucial role in regulating intermuscular bone development in fish and lays the groundwork for further exploration of the role of the Asb15b gene in zebrafish intermuscular bone development.PMID:38754570 | DOI:10.1016/j.gene.2024.148561 (Source: Gene)
Source: Gene - May 16, 2024 Category: Genetics & Stem Cells Authors: Minghui Niu Huamin Whang Zhichao Wu None ShouwenJiang Liangbiao Chen Source Type: research

Investigate the potential impact of Hemagglutinin from the H1N1 strain on severe pneumonia
In conclusion, HA alone, but not the whole H1N1 virus, induces lung tissue injury by inhibiting cell proliferation and migration, while promoting the expression of inflammatory cytokines and apoptosis.PMID:38740352 | DOI:10.1016/j.gene.2024.148559 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Yu-Bi Zheng Song Lu Tian-Bao Chu Gui-Feng Pang Lin-Ying Yang Qing Zhang Source Type: research

Identification and fine mapping of Brmmd1 gene controlling recessive genic male sterility in Brassica rapa L
This study lays a foundation for marker-assisted selection and further molecular mechanism exploration of pollen development in B. rapa.PMID:38740353 | DOI:10.1016/j.gene.2024.148558 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Xingpeng Xiong Xiaoyao Li Shuting Zhang Zhen Hu Tingting Liu Zhengming Qiu Jiashu Cao Li Huang Chenghuan Yan Source Type: research

Investigation of diabetes-related molecular changes in embryo-endometrium crosstalk
This study serves as a valuable guide for investigating the mechanisms responsible for complications in diabetic pregnancies. By revealing the early-stage effects of diabetes, it offers insight into the development of new diagnostic and treatment approaches, ultimately contributing to improved patient care.PMID:38740354 | DOI:10.1016/j.gene.2024.148557 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Semih Tan Se çil Tan Onur Tokg ün H ülya Çetin Elvan Tokg ün Saim Özdamar Source Type: research

Investigate the potential impact of Hemagglutinin from the H1N1 strain on severe pneumonia
In conclusion, HA alone, but not the whole H1N1 virus, induces lung tissue injury by inhibiting cell proliferation and migration, while promoting the expression of inflammatory cytokines and apoptosis.PMID:38740352 | DOI:10.1016/j.gene.2024.148559 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Yu-Bi Zheng Song Lu Tian-Bao Chu Gui-Feng Pang Lin-Ying Yang Qing Zhang Source Type: research

Identification and fine mapping of Brmmd1 gene controlling recessive genic male sterility in Brassica rapa L
This study lays a foundation for marker-assisted selection and further molecular mechanism exploration of pollen development in B. rapa.PMID:38740353 | DOI:10.1016/j.gene.2024.148558 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Xingpeng Xiong Xiaoyao Li Shuting Zhang Zhen Hu Tingting Liu Zhengming Qiu Jiashu Cao Li Huang Chenghuan Yan Source Type: research

Investigation of diabetes-related molecular changes in embryo-endometrium crosstalk
This study serves as a valuable guide for investigating the mechanisms responsible for complications in diabetic pregnancies. By revealing the early-stage effects of diabetes, it offers insight into the development of new diagnostic and treatment approaches, ultimately contributing to improved patient care.PMID:38740354 | DOI:10.1016/j.gene.2024.148557 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Semih Tan Se çil Tan Onur Tokg ün H ülya Çetin Elvan Tokg ün Saim Özdamar Source Type: research

Investigate the potential impact of Hemagglutinin from the H1N1 strain on severe pneumonia
In conclusion, HA alone, but not the whole H1N1 virus, induces lung tissue injury by inhibiting cell proliferation and migration, while promoting the expression of inflammatory cytokines and apoptosis.PMID:38740352 | DOI:10.1016/j.gene.2024.148559 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Yu-Bi Zheng Song Lu Tian-Bao Chu Gui-Feng Pang Lin-Ying Yang Qing Zhang Source Type: research

Identification and fine mapping of Brmmd1 gene controlling recessive genic male sterility in Brassica rapa L
This study lays a foundation for marker-assisted selection and further molecular mechanism exploration of pollen development in B. rapa.PMID:38740353 | DOI:10.1016/j.gene.2024.148558 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Xingpeng Xiong Xiaoyao Li Shuting Zhang Zhen Hu Tingting Liu Zhengming Qiu Jiashu Cao Li Huang Chenghuan Yan Source Type: research

Investigation of diabetes-related molecular changes in embryo-endometrium crosstalk
This study serves as a valuable guide for investigating the mechanisms responsible for complications in diabetic pregnancies. By revealing the early-stage effects of diabetes, it offers insight into the development of new diagnostic and treatment approaches, ultimately contributing to improved patient care.PMID:38740354 | DOI:10.1016/j.gene.2024.148557 (Source: Gene)
Source: Gene - May 13, 2024 Category: Genetics & Stem Cells Authors: Semih Tan Se çil Tan Onur Tokg ün H ülya Çetin Elvan Tokg ün Saim Özdamar Source Type: research

Spirulina versus metformin for controlling some insulin signaling pathway genes in induced polycystic ovary syndrome rat model
Gene. 2024 May 10:148524. doi: 10.1016/j.gene.2024.148524. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is a prevalent endocrinologic and gynecologic disorder that affects women of reproductive age; besides, insulin resistance (IR) occurs in 50-70 % of PCOS cases. Metformin (Met) is commonly prescribed for IR management; however, it does not affect IR with some gastrointestinal symptoms. Spirulina platensis (SP) is a blue-green alga that may increase insulin sensitivity. Therefore, our study aims to evaluate SP as an alternative treatment to Met for improving glucose homeostasis by assessing the expressio...
Source: Gene - May 12, 2024 Category: Genetics & Stem Cells Authors: Asmaa A El Leithy Mohamed Abozaid Ahmed A Al-Karmalawy Rasha Mahmoud Allam Anas Zakarya Nourelden Rodina M Amer Nesreen H Abd El Azeem Faten Sabra Abo-Zeid Source Type: research