Identification of hub genes and potential therapeutic mechanisms related to HPV positive head and neck squamous carcinoma based on full transcriptomic detection and ceRNA network construction
This study based on the ceRNA network provides valuable insights into the molecular mechanisms and potential therapeutic strategies for HPV+ HNSCC, and provide theoretical basis for the exploration of HPV+ HNSCC biomarkers and the development of targeted drugs.PMID:38428621 | DOI:10.1016/j.gene.2024.148321 (Source: Gene)
Source: Gene - March 1, 2024 Category: Genetics & Stem Cells Authors: Kunpeng Wang Tingting Zhang Xia Li Xinran Zhang Rui Li Boyu Pan Jiayin Deng Source Type: research
Cellular senescence molecules expression in type 2 diabetes mellitus: CDKN2A, CDKN2B, and lncRNA ANRIL
CONCLUSIONS: Cellular senescence may have a protective effect against T2DM. In addition, the cellular senescence molecules CDKN2A and ANRIL may be potential biomarkers of cellular senescence in T2DM.PMID:38428622 | DOI:10.1016/j.gene.2024.148319 (Source: Gene)
Source: Gene - March 1, 2024 Category: Genetics & Stem Cells Authors: Soheila Anaraki Masoumeh Kheirandish Pegah Mousavi Atefe Ebrahimi Tamandegani Samane Mohammadi Mohammad Shekari Source Type: research
Identification of hub genes and potential therapeutic mechanisms related to HPV positive head and neck squamous carcinoma based on full transcriptomic detection and ceRNA network construction
This study based on the ceRNA network provides valuable insights into the molecular mechanisms and potential therapeutic strategies for HPV+ HNSCC, and provide theoretical basis for the exploration of HPV+ HNSCC biomarkers and the development of targeted drugs.PMID:38428621 | DOI:10.1016/j.gene.2024.148321 (Source: Gene)
Source: Gene - March 1, 2024 Category: Genetics & Stem Cells Authors: Kunpeng Wang Tingting Zhang Xia Li Xinran Zhang Rui Li Boyu Pan Jiayin Deng Source Type: research
Cellular senescence molecules expression in type 2 diabetes mellitus: CDKN2A, CDKN2B, and lncRNA ANRIL
CONCLUSIONS: Cellular senescence may have a protective effect against T2DM. In addition, the cellular senescence molecules CDKN2A and ANRIL may be potential biomarkers of cellular senescence in T2DM.PMID:38428622 | DOI:10.1016/j.gene.2024.148319 (Source: Gene)
Source: Gene - March 1, 2024 Category: Genetics & Stem Cells Authors: Soheila Anaraki Masoumeh Kheirandish Pegah Mousavi Atefe Ebrahimi Tamandegani Samane Mohammadi Mohammad Shekari Source Type: research
Identification of two MEF2s and their role in inhibiting the transcription of the mstn2a gene in the yellowfin seabream, Acanthopagrus latus (Hottuyn, 1782)
Gene. 2024 Feb 27:148322. doi: 10.1016/j.gene.2024.148322. Online ahead of print.ABSTRACTMyocyte-specific enhancer binding factor 2 (MEF2), which belongs to the MADS superfamily, is a pivotal and conserved transcription factor that combines with the E-box motif to control the expression of muscle genes. Myostatin (mstn), a muscle growth inhibitor, is a vital member of the TGF-β superfamily. Currently, an understanding of the mechanisms of A. latus mstn (Almstn) transcriptional regulation mediated by MEF2 in fish muscle development is lacking. In the present study, two AlMEF2s (AlMEF2A and AlMEF2B) and Almstn2a were charac...
Source: Gene - February 29, 2024 Category: Genetics & Stem Cells Authors: Kecheng Zhu Hongxi He Huayang Guo Baosuo Liu Xin He Nan Zhang Lin Xian Dianchang Zhang Source Type: research
Transient receptor potential (TRP) channels in Sebastes schlegelii: Genome-wide identification and ThermoTRP expression analysis under high-temperature
This study lays the foundation for understanding the regulatory mechanisms of TRPs responses to environmental stimuli in S. schlegelii and other fishes.PMID:38423141 | DOI:10.1016/j.gene.2024.148317 (Source: Gene)
Source: Gene - February 29, 2024 Category: Genetics & Stem Cells Authors: Jinwei Huang Xueying Wang Xiaoyang Guo Qinghua Liu Jun Li Source Type: research
Identification of two MEF2s and their role in inhibiting the transcription of the mstn2a gene in the yellowfin seabream, Acanthopagrus latus (Hottuyn, 1782)
Gene. 2024 Feb 27:148322. doi: 10.1016/j.gene.2024.148322. Online ahead of print.ABSTRACTMyocyte-specific enhancer binding factor 2 (MEF2), which belongs to the MADS superfamily, is a pivotal and conserved transcription factor that combines with the E-box motif to control the expression of muscle genes. Myostatin (mstn), a muscle growth inhibitor, is a vital member of the TGF-β superfamily. Currently, an understanding of the mechanisms of A. latus mstn (Almstn) transcriptional regulation mediated by MEF2 in fish muscle development is lacking. In the present study, two AlMEF2s (AlMEF2A and AlMEF2B) and Almstn2a were charac...
Source: Gene - February 29, 2024 Category: Genetics & Stem Cells Authors: Kecheng Zhu Hongxi He Huayang Guo Baosuo Liu Xin He Nan Zhang Lin Xian Dianchang Zhang Source Type: research
Transient receptor potential (TRP) channels in Sebastes schlegelii: Genome-wide identification and ThermoTRP expression analysis under high-temperature
This study lays the foundation for understanding the regulatory mechanisms of TRPs responses to environmental stimuli in S. schlegelii and other fishes.PMID:38423141 | DOI:10.1016/j.gene.2024.148317 (Source: Gene)
Source: Gene - February 29, 2024 Category: Genetics & Stem Cells Authors: Jinwei Huang Xueying Wang Xiaoyang Guo Qinghua Liu Jun Li Source Type: research
Genomic insights into glume pubescence in durum wheat: GWAS and haplotype analysis implicates TdELD1-1A as a candidate gene
Gene. 2024 Feb 26:148309. doi: 10.1016/j.gene.2024.148309. Online ahead of print.ABSTRACTGlume pubescence is an important morphological trait for the characterization of wheat cultivars. It shows tolerance to biotic and abiotic stresses to some extent. Hg1 (formerly named Hg) locus on chromosome 1AS controls glume pubescence in wheat. Its genetic analysis, fine-mapping and candidate gene analysis have been widely studied recently, however, the cloning of Hg1 has not yet been reported. Here, we conducted a GWAS between a dense panel of 171,103 SNPs and glume pubescence (Gp) in a durum wheat population of 145 lines, and furt...
Source: Gene - February 28, 2024 Category: Genetics & Stem Cells Authors: Xin Hu Muhammad Yasir Yujie Zhuo Yijing Cai Xifeng Ren Junkang Rong Source Type: research
Geometric Analysis of SARS-CoV-2 Variants
In this study, we constructed a geometric space to represent all SARS-CoV-2 sequences of different variants. An alignment-free method: natural vector method was utilized to establish genome space. The genome space of SARS-CoV-2 was constructed based on the 24-dimensional natural vector and the appropriate metric was determined through performing phylogenetic analysises. Phylogenetic trees of different lineages constructed under the selected natural vector and metric coincided with the lineage naming standards, which means lineages with same alphabetical prefix cluster in phylogenetic trees. Furthermore, the relationships b...
Source: Gene - February 28, 2024 Category: Genetics & Stem Cells Authors: Mengcen Guan Nan Sun Stephen S-T Yau Source Type: research
The Complete Mitochondrial Genome of Penicillium expansum: Insights Into the Fungal Evolution and Phylogeny
This study served as a first report on the complete mitochondrial genome of P. expansum and its comparative analysis that will contribute to population genetics and rapid evolutionary studies among Penicillium species.PMID:38417689 | DOI:10.1016/j.gene.2024.148315 (Source: Gene)
Source: Gene - February 28, 2024 Category: Genetics & Stem Cells Authors: Mahnoor Malik Fatima Malik Tehsin Fatma Muhammad Qasim Hayat Atif Jamal Alvina Gul Muhammad Faraz Bhatti Source Type: research
Association of FSHR gene polymorphisms with poor ovarian response in patients undergoing IVF: A systematic review and meta-analysis
CONCLUSION: According to the current meta-analysis, the rs6166 S allele was significantly associated with an increased risk of POR, especially in Asian populations. The rs6165 T allele was significantly associated with an increased risk of POR, especially in Caucasian populations.PMID:38412944 | DOI:10.1016/j.gene.2024.148314 (Source: Gene)
Source: Gene - February 27, 2024 Category: Genetics & Stem Cells Authors: Siya Hu Yunnan Jing Yiman Fu Xiuying Ye Source Type: research
A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway
CONCLUSION: We confirmed the pathogenicity of the large deletion in TSC2 in a three- generations family.. Deletion of exon 4 of TSC2 affected cell proliferation, migration, and cell cycle via abnormal activation of the PAM pathway. This study evaluated the pathogenic effect of deletion of exon 4 of TSC2 and investigated the underlying mechanism.PMID:38412945 | DOI:10.1016/j.gene.2024.148312 (Source: Gene)
Source: Gene - February 27, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Association of FSHR gene polymorphisms with poor ovarian response in patients undergoing IVF: A systematic review and meta-analysis
CONCLUSION: According to the current meta-analysis, the rs6166 S allele was significantly associated with an increased risk of POR, especially in Asian populations. The rs6165 T allele was significantly associated with an increased risk of POR, especially in Caucasian populations.PMID:38412944 | DOI:10.1016/j.gene.2024.148314 (Source: Gene)
Source: Gene - February 27, 2024 Category: Genetics & Stem Cells Authors: Siya Hu Yunnan Jing Yiman Fu Xiuying Ye Source Type: research
A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway
CONCLUSION: We confirmed the pathogenicity of the large deletion in TSC2 in a three- generations family.. Deletion of exon 4 of TSC2 affected cell proliferation, migration, and cell cycle via abnormal activation of the PAM pathway. This study evaluated the pathogenic effect of deletion of exon 4 of TSC2 and investigated the underlying mechanism.PMID:38412945 | DOI:10.1016/j.gene.2024.148312 (Source: Gene)
Source: Gene - February 27, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
