Cold-adapted Exiguobacterium sibiricum K1 as a potential bioinoculant in cold regions: Physiological and genomic elucidation of biocontrol and plant growth promotion
Gene. 2024 Apr 5:148439. doi: 10.1016/j.gene.2024.148439. Online ahead of print.ABSTRACTThe scarcity of soil nutrient availability under cold conditions of Himalayan regions needs a sustainable approach for better crop yields. The cold-adapted bacteria, Exiguobacterium sibiricum K1, with the potential to produce several plant growth-promoting (PGP) attributes, nitrogen fixation, indole acetic acid production, phosphate and potassium solubilization at 10 °C can provide an opportunity to promote crop yield improvement in an eco-friendly way under cold conditions. The bacterium also exhibited biocontrol activity against two ...
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Sareeka Kumari Anil Kumar Ayush Lepcha Rakshak Kumar Source Type: research
The immunoregulatory property of mesenchymal stem cells in Crocin treatment by expression modulation of microRNA-155, microRNA-21, microRNA-23b, microRNA-126a, and their target inflammatory genes
In conclusion, Crocin could control essential signaling pathways related to the inflammation by regulating the expression of related- miRNAs genes that play a key function in the immune regulation pathways in MSCs. Our findings can give an understanding of the mechanisms by which Crocin enhances the immunomodulatory feature of MSCs. According to the research findings, DP-SCs are probably a better immunomodulator in Crocin treatment than Ad-SCs and it may be helpful for MSCs selection in clinical applications for modulation or treatment of autoimmune disorders.PMID:38583816 | DOI:10.1016/j.gene.2024.148446 (Source: Gene)
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Zeinab Rostami Mansoore Saharkhiz Mohsen Khorashadizadeh Malaksima Ayadilord Mohsen Naseri Source Type: research
DNA barcoding, phylogeography and evolutionary dynamics of Chrysichthys auratus
This study embarked on an exploration into the genetic structure and evolutionary history of the Chrysichthys auratus species, leveraging PCR amplification, phylogenetic trees, and haplotype networks. Specific DNA segments were successfully amplified and visualized through electrophoresis. Newly obtained sequences were Bank into GenBank and given accession numbers (OR730807-OR730808-OR730809). The Neighbor-Joining method provided insights into the evolutionary relationships among taxa, further augmented by bootstrap values and the Tamura 3-parameter method. A comprehensive geographical haplotype network showcased pronounce...
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Moharam Adel Mohamed Afifi Ahmad Mosad Azab Elham Ali Ahmed Ghazy Mohamed Ahmed Mohamed El-Tabakh Source Type: research
Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks
Gene. 2024 Apr 5:148447. doi: 10.1016/j.gene.2024.148447. Online ahead of print.ABSTRACT"The grand orchestrator," "Universal Amplifier," "double-edged sword," and "Undruggable" are just some of the Myc oncogene so-called names. It has been around 40 years since the discovery of the Myc, and it remains in the mainstream of cancer treatment drugs. Myc is part of basic helix-loop-helix leucine zipper (bHLH-LZ) superfamily proteins, and its dysregulation can be seen in many malignant human tumors. It dysregulates critical pathways in cells that are connected to each other, such as proliferation, growth, cell cycle, and cell ad...
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Nima Ghasemi Hossein Azizi Source Type: research
Cold-adapted Exiguobacterium sibiricum K1 as a potential bioinoculant in cold regions: Physiological and genomic elucidation of biocontrol and plant growth promotion
Gene. 2024 Apr 5:148439. doi: 10.1016/j.gene.2024.148439. Online ahead of print.ABSTRACTThe scarcity of soil nutrient availability under cold conditions of Himalayan regions needs a sustainable approach for better crop yields. The cold-adapted bacteria, Exiguobacterium sibiricum K1, with the potential to produce several plant growth-promoting (PGP) attributes, nitrogen fixation, indole acetic acid production, phosphate and potassium solubilization at 10 °C can provide an opportunity to promote crop yield improvement in an eco-friendly way under cold conditions. The bacterium also exhibited biocontrol activity against two ...
Source: Gene - April 7, 2024 Category: Genetics & Stem Cells Authors: Sareeka Kumari Anil Kumar Ayush Lepcha Rakshak Kumar Source Type: research
Circular RNAs: Epigenetic regulators of PTEN expression and function in cancer
Gene. 2024 Apr 4:148442. doi: 10.1016/j.gene.2024.148442. Online ahead of print.ABSTRACTEpigenetic regulation of gene expression, without altering the DNA sequence, is involved in many normal cellular growth and division events, as well as diseases such as cancer. Epigenetics is no longer limited to the nucleus, methylation, and histone modification, but regulatory non-coding RNAs (ncRNAs) also play an important role in epigenetics. Circular RNAs (circRNAs), single-stranded RNAs without 3' and 5' ends, have recently emerged as a class of ncRNAs that regulate gene expression. CircRNAs regulate phosphatase and tensin homolog...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Mohammad-Mojtaba Farazi Saeideh Jafarinejad-Farsangi Zahra Miri Karam Maryam Gholizadeh Maryam Haddadi Abolfazl Yari Source Type: research
ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR/DDX11/PML-RAR α signaling axis
In this study, acute promyelocytic leukemia NB4 cells before and after ATPR induction were analyzed by whole transcriptome microarray, and the expression of lncRNA CONCR was found to be significantly downregulated. The role of CONCR in ATPR-induced cell differentiation and cycle arrest was explored through overexpression and silencing of CONCR. And then the database was used to predict that CONCR may bind to DEAD/H-Box Helicase 11 (DDX11) protein to further explore the role of CONCR binding to DDX11. The results showed that ATPR could reduce the expression of CONCR, and overexpression of CONCR could reverse the ATPR-induce...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Shen Liu Wenjing Zhan Xiong He Mengjia Hao Wenwen Shen Xiaoyue Zhang Meng Wang Zihan Li Ruirui Hou Ziyao Ou Yubin Feng Feihu Chen Source Type: research
Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families
We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies, and postmortem genetic testing from probands, and clinical evaluation, genetic testing and blood transcript analysis in family members. All the cases harbored biallelic PPA2 variants in compound heterozygous status. Two brothers from family 1 suffered sudden death after a small first intake of alcohol in 2013 and 2022. The sister remains alive but affected with cardiomyopathy, extensive scar on cardiac imaging, and high sensitivity to alcohol intake. The three sibli...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Cristina G ómez González Iv án Del Campo Cano Ana Isabel Fern ández-Avila Maria Paz Su árez-Mier Mar ía José Sagastizábal Reyes Álvarez García-Rovés Irene M éndez Fernández Silvia Vilches Miriam Centeno Jim énez Ana Siles S ánchez-Manjavaca Source Type: research
Circular RNAs: Epigenetic regulators of PTEN expression and function in cancer
Gene. 2024 Apr 4:148442. doi: 10.1016/j.gene.2024.148442. Online ahead of print.ABSTRACTEpigenetic regulation of gene expression, without altering the DNA sequence, is involved in many normal cellular growth and division events, as well as diseases such as cancer. Epigenetics is no longer limited to the nucleus, methylation, and histone modification, but regulatory non-coding RNAs (ncRNAs) also play an important role in epigenetics. Circular RNAs (circRNAs), single-stranded RNAs without 3' and 5' ends, have recently emerged as a class of ncRNAs that regulate gene expression. CircRNAs regulate phosphatase and tensin homolog...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Mohammad-Mojtaba Farazi Saeideh Jafarinejad-Farsangi Zahra Miri Karam Maryam Gholizadeh Maryam Haddadi Abolfazl Yari Source Type: research
ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR/DDX11/PML-RAR α signaling axis
In this study, acute promyelocytic leukemia NB4 cells before and after ATPR induction were analyzed by whole transcriptome microarray, and the expression of lncRNA CONCR was found to be significantly downregulated. The role of CONCR in ATPR-induced cell differentiation and cycle arrest was explored through overexpression and silencing of CONCR. And then the database was used to predict that CONCR may bind to DEAD/H-Box Helicase 11 (DDX11) protein to further explore the role of CONCR binding to DDX11. The results showed that ATPR could reduce the expression of CONCR, and overexpression of CONCR could reverse the ATPR-induce...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Shen Liu Wenjing Zhan Xiong He Mengjia Hao Wenwen Shen Xiaoyue Zhang Meng Wang Zihan Li Ruirui Hou Ziyao Ou Yubin Feng Feihu Chen Source Type: research
Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families
We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies, and postmortem genetic testing from probands, and clinical evaluation, genetic testing and blood transcript analysis in family members. All the cases harbored biallelic PPA2 variants in compound heterozygous status. Two brothers from family 1 suffered sudden death after a small first intake of alcohol in 2013 and 2022. The sister remains alive but affected with cardiomyopathy, extensive scar on cardiac imaging, and high sensitivity to alcohol intake. The three sibli...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Cristina G ómez González Iv án Del Campo Cano Ana Isabel Fern ández-Avila Maria Paz Su árez-Mier Mar ía José Sagastizábal Reyes Álvarez García-Rovés Irene M éndez Fernández Silvia Vilches Miriam Centeno Jim énez Ana Siles S ánchez-Manjavaca Source Type: research
Identification of activating transcription factor 6 (ATF6) as a novel prognostic biomarker and potential target in oral squamous cell carcinoma
CONCLUSION: We propose that ATF6 holds potential as a prognostic biomarker linked to autophagy in OSCC. This study provides valuable clues for further exploration of targeted therapy against OSCC.PMID:38579904 | DOI:10.1016/j.gene.2024.148436 (Source: Gene)
Source: Gene - April 5, 2024 Category: Genetics & Stem Cells Authors: Yan Wu Qiang Xie Lifeng Wu Zhijia Li Xiaojing Li Lan Zhang Bin Zhang Source Type: research
Exploring the mechanism of Corbrin capsules in the intervention of AKI-COVID-19 based on network pharmacology combined with GEO dataset
CONCLUSION: This study revealed the key components, targets, and pathways involved in treating AKI-related COVID-19 using Corbrin capsules. This study also provided a new understanding of the molecular mechanisms underlying this treatment.PMID:38579905 | DOI:10.1016/j.gene.2024.148438 (Source: Gene)
Source: Gene - April 5, 2024 Category: Genetics & Stem Cells Authors: Xiu-Juan Qin Wen-Jie Hu Xian-Jin Xu Source Type: research
Insights into the nuclear and mitochondrial genome of the Lemon shark < em > Negaprion brevirostris < /em > using low-coverage sequencing: Genome size, repetitive elements, mitochondrial genome, and phylogenetic placement
Gene. 2024 Feb 5;894:147939. doi: 10.1016/j.gene.2023.147939. Epub 2023 Oct 29.ABSTRACTThe Lemon shark Negaprion brevirostris is an important species experiencing conservation issues that is in need of genomic resources. Herein, we conducted a genome survey sequencing in N. brevirostris and determined genome size, explored repetitive elements, assembled and annotated the 45S rRNA DNA operon, and assembled and described in detail the mitochondrial genome. Lastly, the phylogenetic position of N. brevirostris in the family Carcharhinidae was examined using translated protein coding genes. The estimated haploid genome size ran...
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: J Antonio Baeza Natalie C Stephens Alyssa Baker Andrew Lyons Bryan Franks Stacy Pirro Kevin A Feldheim Source Type: research
A positive selection at binding site 501 in the B.1 lineage might have triggered the highly infectious sub-lineages of SARS-CoV-2
This study sheds light on the evolutionary trajectory of the B lineage into highly infectious descendants in the recent past under the influence of positive and purifying selection exerted by natural immunity and vaccination of the host.PMID:38575097 | DOI:10.1016/j.gene.2024.148427 (Source: Gene)
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Basant K Tiwary Source Type: research
