Recurrence of CCHS-associated PHOX2B Poly-Alanine expansion variant due to paternal mosaicism
CONCLUSIONS: These findings have important implications for improving genetic counseling of CCHS families as they suggest that even parents without CCHS symptoms may have somatic chimerism, necessitating careful genetic counseling and consideration of prenatal testing for subsequent pregnancies.PMID:38467313 | DOI:10.1016/j.gene.2024.148358 (Source: Gene)
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Huling Jiang Zepeng Ping Suping Li Jianjun Zhu Source Type: research
Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer
CONCLUSION: PANoptosis holds an important role in BC prognosis and treatment.PMID:38467314 | DOI:10.1016/j.gene.2024.148355 (Source: Gene)
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Qiuchen Qi Mengqian Zhu Peilong Li Qi Mi Yan Xie Juan Li Chuanxin Wang Source Type: research
AtERF13 and AtERF6 double knockout fine-tunes growth and the transcriptome to promote cadmium tolerance in Arabidopsis
Gene. 2024 Mar 11;911:148348. doi: 10.1016/j.gene.2024.148348. Online ahead of print.ABSTRACTThe toxic heavy metal cadmium (Cd) restricts plant growth. However, how plants fine-tune their growth to modulate Cd resistance has not been determined. Ethylene response factors (ERFs) are key regulators of Cd stress, and Arabidopsis thaliana ERF13 and ERF6 (AtERF13 and AtERF6) negatively regulate growth. We previously demonstrated that AtERF13 is a transcriptional activator that binds a Cd-responsive element. Herein, we report that Arabidopsis plants improve Cd tolerance by repressing AtERF13 and AtERF6. We found that AtERF13 and...
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Wanxia Chen Yang Shi Chunying Wang Xiaoting Qi Source Type: research
A Chinese model for legal regulation of Gene-Edited endangered animals and plants
Gene. 2024 Mar 11;911:148350. doi: 10.1016/j.gene.2024.148350. Online ahead of print.ABSTRACTThe application of gene editing technology in the field of endangered plant and animal conservation has innovative and prospective value in saving endangered plant and animal populations, but it also poses challenges to the ecological environment and bioethical norms. Gene editing has impacted China's animal and plant protection legal system, and this study aims to provide solutions for China to regulate gene editing of endangered plants and animals. The study concludes that China should enact specific legislation on gene editing o...
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Tao Li Source Type: research
Recurrence of CCHS-associated PHOX2B Poly-Alanine expansion variant due to paternal mosaicism
CONCLUSIONS: These findings have important implications for improving genetic counseling of CCHS families as they suggest that even parents without CCHS symptoms may have somatic chimerism, necessitating careful genetic counseling and consideration of prenatal testing for subsequent pregnancies.PMID:38467313 | DOI:10.1016/j.gene.2024.148358 (Source: Gene)
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Huling Jiang Zepeng Ping Suping Li Jianjun Zhu Source Type: research
Systematic analysis of PANoptosis-related genes identifies XIAP as a functional oncogene in breast cancer
CONCLUSION: PANoptosis holds an important role in BC prognosis and treatment.PMID:38467314 | DOI:10.1016/j.gene.2024.148355 (Source: Gene)
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Qiuchen Qi Mengqian Zhu Peilong Li Qi Mi Yan Xie Juan Li Chuanxin Wang Source Type: research
AtERF13 and AtERF6 double knockout fine-tunes growth and the transcriptome to promote cadmium tolerance in Arabidopsis
Gene. 2024 Mar 9:148348. doi: 10.1016/j.gene.2024.148348. Online ahead of print.ABSTRACTThe toxic heavy metal cadmium (Cd) restricts plant growth. However, how plants fine-tune their growth to modulate Cd resistance has not been determined. Ethylene response factors (ERFs) are key regulators of Cd stress, and Arabidopsis thaliana ERF13 and ERF6 (AtERF13 and AtERF6) negatively regulate growth. We previously demonstrated that AtERF13 is a transcriptional activator that binds a Cd-responsive element. Herein, we report that Arabidopsis plants improve Cd tolerance by repressing AtERF13 and AtERF6. We found that AtERF13 and AtER...
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Wanxia Chen Yang Shi Chunying Wang Xiaoting Qi Source Type: research
A Chinese model for legal regulation of Gene-Edited endangered animals and plants
Gene. 2024 Mar 9:148350. doi: 10.1016/j.gene.2024.148350. Online ahead of print.ABSTRACTThe application of gene editing technology in the field of endangered plant and animal conservation has innovative and prospective value in saving endangered plant and animal populations, but it also poses challenges to the ecological environment and bioethical norms. Gene editing has impacted China's animal and plant protection legal system, and this study aims to provide solutions for China to regulate gene editing of endangered plants and animals. The study concludes that China should enact specific legislation on gene editing of end...
Source: Gene - March 11, 2024 Category: Genetics & Stem Cells Authors: Tao Li Source Type: research
Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation
CONCLUSION: This study provides a comprehensive understanding of the potential therapeutic targets and mechanisms of action of Andrographolide in OA treatment. Our findings suggest that Andrographolide is a promising candidate for drug development in the management of OA.PMID:38462021 | DOI:10.1016/j.gene.2024.148351 (Source: Gene)
Source: Gene - March 10, 2024 Category: Genetics & Stem Cells Authors: Tengyun Yang Tingting Cao Xianguang Yang Guoliang Wang Yanlin Li Source Type: research
Exploring the biological diversity and source species of medicinal horseflies through metabarcoding
In conclusion, our findings offer valuable insights into the biological composition of crude drugs derived from horseflies and have the potential to enhance the quality of these traditional medicines.PMID:38462022 | DOI:10.1016/j.gene.2024.148356 (Source: Gene)
Source: Gene - March 10, 2024 Category: Genetics & Stem Cells Authors: Tenukeguli Tuliebieke None Abdullah Huanyu Zhang Rushan Yan Hui Li Yue Zhang Tingting Zhang Ibrar Ahmed Tianxiang Li Xiaoxuan Tian Source Type: research
Investigating the effect of hesperetin on estrogen receptor alpha (ER α) expression, phosphorylation and activity in MCF-7 cells
CONCLUSION: Based on the results of this study, it can be concluded that hesperetin has a significant effect on ERα expression, phosphorylation and activity.PMID:38462023 | DOI:10.1016/j.gene.2024.148357 (Source: Gene)
Source: Gene - March 10, 2024 Category: Genetics & Stem Cells Authors: Ramin Vosooghi Alireza Motavalizadehkakhky Atena Mansouri Jamshid Mehrzad Masood Homayouni Source Type: research
Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation
CONCLUSION: This study provides a comprehensive understanding of the potential therapeutic targets and mechanisms of action of Andrographolide in OA treatment. Our findings suggest that Andrographolide is a promising candidate for drug development in the management of OA.PMID:38462021 | DOI:10.1016/j.gene.2024.148351 (Source: Gene)
Source: Gene - March 10, 2024 Category: Genetics & Stem Cells Authors: Tengyun Yang Tingting Cao Xianguang Yang Guoliang Wang Yanlin Li Source Type: research
Exploring the biological diversity and source species of medicinal horseflies through metabarcoding
In conclusion, our findings offer valuable insights into the biological composition of crude drugs derived from horseflies and have the potential to enhance the quality of these traditional medicines.PMID:38462022 | DOI:10.1016/j.gene.2024.148356 (Source: Gene)
Source: Gene - March 10, 2024 Category: Genetics & Stem Cells Authors: Tenukeguli Tuliebieke None Abdullah Huanyu Zhang Rushan Yan Hui Li Yue Zhang Tingting Zhang Ibrar Ahmed Tianxiang Li Xiaoxuan Tian Source Type: research
Investigating the effect of hesperetin on estrogen receptor alpha (ER α) expression, phosphorylation and activity in MCF-7 cells
CONCLUSION: Based on the results of this study, it can be concluded that hesperetin has a significant effect on ERα expression, phosphorylation and activity.PMID:38462023 | DOI:10.1016/j.gene.2024.148357 (Source: Gene)
Source: Gene - March 10, 2024 Category: Genetics & Stem Cells Authors: Ramin Vosooghi Alireza Motavalizadehkakhky Atena Mansouri Jamshid Mehrzad Masood Homayouni Source Type: research
Comparative chloroplast genomes study of five officinal Ardisia Species: Unraveling interspecific diversity and evolutionary insights in Ardisia
Gene. 2024 Mar 7:148349. doi: 10.1016/j.gene.2024.148349. Online ahead of print.ABSTRACTArdisia S.W. (Primulaceae), naturally distributed in tropical and subtropical areas, has edible and medicinal values and is prevalent in clinical and daily use in China. More genetic information for distinct species delineation is needed to support the development and utilization of the genus Ardisia. We sequenced, annotated, and compared the chloroplast genomes of five Ardisia species: A. brunnescens, A. pusilla, A. squamulosa, A. crenata, and A. brevicaulis in this study. We found a typical quadripartite structure in all five chloropl...
Source: Gene - March 9, 2024 Category: Genetics & Stem Cells Authors: Lichai Yuan Yang Ni Haimei Chen Jingling Li Qianqi Lu Liqiang Wang Xinyi Zhang Jingwen Yue Heyu Yang Chang Liu Source Type: research
