Circular RNAs: Epigenetic regulators of PTEN expression and function in cancer
Gene. 2024 Apr 4:148442. doi: 10.1016/j.gene.2024.148442. Online ahead of print.ABSTRACTEpigenetic regulation of gene expression, without altering the DNA sequence, is involved in many normal cellular growth and division events, as well as diseases such as cancer. Epigenetics is no longer limited to the nucleus, methylation, and histone modification, but regulatory non-coding RNAs (ncRNAs) also play an important role in epigenetics. Circular RNAs (circRNAs), single-stranded RNAs without 3' and 5' ends, have recently emerged as a class of ncRNAs that regulate gene expression. CircRNAs regulate phosphatase and tensin homolog...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Mohammad-Mojtaba Farazi Saeideh Jafarinejad-Farsangi Zahra Miri Karam Maryam Gholizadeh Maryam Haddadi Abolfazl Yari Source Type: research
ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR/DDX11/PML-RAR α signaling axis
In this study, acute promyelocytic leukemia NB4 cells before and after ATPR induction were analyzed by whole transcriptome microarray, and the expression of lncRNA CONCR was found to be significantly downregulated. The role of CONCR in ATPR-induced cell differentiation and cycle arrest was explored through overexpression and silencing of CONCR. And then the database was used to predict that CONCR may bind to DEAD/H-Box Helicase 11 (DDX11) protein to further explore the role of CONCR binding to DDX11. The results showed that ATPR could reduce the expression of CONCR, and overexpression of CONCR could reverse the ATPR-induce...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Shen Liu Wenjing Zhan Xiong He Mengjia Hao Wenwen Shen Xiaoyue Zhang Meng Wang Zihan Li Ruirui Hou Ziyao Ou Yubin Feng Feihu Chen Source Type: research
Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families
We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies, and postmortem genetic testing from probands, and clinical evaluation, genetic testing and blood transcript analysis in family members. All the cases harbored biallelic PPA2 variants in compound heterozygous status. Two brothers from family 1 suffered sudden death after a small first intake of alcohol in 2013 and 2022. The sister remains alive but affected with cardiomyopathy, extensive scar on cardiac imaging, and high sensitivity to alcohol intake. The three sibli...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Cristina G ómez González Iv án Del Campo Cano Ana Isabel Fern ández-Avila Maria Paz Su árez-Mier Mar ía José Sagastizábal Reyes Álvarez García-Rovés Irene M éndez Fernández Silvia Vilches Miriam Centeno Jim énez Ana Siles S ánchez-Manjavaca Source Type: research
Circular RNAs: Epigenetic regulators of PTEN expression and function in cancer
Gene. 2024 Apr 4:148442. doi: 10.1016/j.gene.2024.148442. Online ahead of print.ABSTRACTEpigenetic regulation of gene expression, without altering the DNA sequence, is involved in many normal cellular growth and division events, as well as diseases such as cancer. Epigenetics is no longer limited to the nucleus, methylation, and histone modification, but regulatory non-coding RNAs (ncRNAs) also play an important role in epigenetics. Circular RNAs (circRNAs), single-stranded RNAs without 3' and 5' ends, have recently emerged as a class of ncRNAs that regulate gene expression. CircRNAs regulate phosphatase and tensin homolog...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Mohammad-Mojtaba Farazi Saeideh Jafarinejad-Farsangi Zahra Miri Karam Maryam Gholizadeh Maryam Haddadi Abolfazl Yari Source Type: research
ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR/DDX11/PML-RAR α signaling axis
In this study, acute promyelocytic leukemia NB4 cells before and after ATPR induction were analyzed by whole transcriptome microarray, and the expression of lncRNA CONCR was found to be significantly downregulated. The role of CONCR in ATPR-induced cell differentiation and cycle arrest was explored through overexpression and silencing of CONCR. And then the database was used to predict that CONCR may bind to DEAD/H-Box Helicase 11 (DDX11) protein to further explore the role of CONCR binding to DDX11. The results showed that ATPR could reduce the expression of CONCR, and overexpression of CONCR could reverse the ATPR-induce...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Shen Liu Wenjing Zhan Xiong He Mengjia Hao Wenwen Shen Xiaoyue Zhang Meng Wang Zihan Li Ruirui Hou Ziyao Ou Yubin Feng Feihu Chen Source Type: research
Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families
We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies, and postmortem genetic testing from probands, and clinical evaluation, genetic testing and blood transcript analysis in family members. All the cases harbored biallelic PPA2 variants in compound heterozygous status. Two brothers from family 1 suffered sudden death after a small first intake of alcohol in 2013 and 2022. The sister remains alive but affected with cardiomyopathy, extensive scar on cardiac imaging, and high sensitivity to alcohol intake. The three sibli...
Source: Gene - April 6, 2024 Category: Genetics & Stem Cells Authors: Cristina G ómez González Iv án Del Campo Cano Ana Isabel Fern ández-Avila Maria Paz Su árez-Mier Mar ía José Sagastizábal Reyes Álvarez García-Rovés Irene M éndez Fernández Silvia Vilches Miriam Centeno Jim énez Ana Siles S ánchez-Manjavaca Source Type: research
Identification of activating transcription factor 6 (ATF6) as a novel prognostic biomarker and potential target in oral squamous cell carcinoma
CONCLUSION: We propose that ATF6 holds potential as a prognostic biomarker linked to autophagy in OSCC. This study provides valuable clues for further exploration of targeted therapy against OSCC.PMID:38579904 | DOI:10.1016/j.gene.2024.148436 (Source: Gene)
Source: Gene - April 5, 2024 Category: Genetics & Stem Cells Authors: Yan Wu Qiang Xie Lifeng Wu Zhijia Li Xiaojing Li Lan Zhang Bin Zhang Source Type: research
Exploring the mechanism of Corbrin capsules in the intervention of AKI-COVID-19 based on network pharmacology combined with GEO dataset
CONCLUSION: This study revealed the key components, targets, and pathways involved in treating AKI-related COVID-19 using Corbrin capsules. This study also provided a new understanding of the molecular mechanisms underlying this treatment.PMID:38579905 | DOI:10.1016/j.gene.2024.148438 (Source: Gene)
Source: Gene - April 5, 2024 Category: Genetics & Stem Cells Authors: Xiu-Juan Qin Wen-Jie Hu Xian-Jin Xu Source Type: research
Insights into the nuclear and mitochondrial genome of the Lemon shark < em > Negaprion brevirostris < /em > using low-coverage sequencing: Genome size, repetitive elements, mitochondrial genome, and phylogenetic placement
Gene. 2024 Feb 5;894:147939. doi: 10.1016/j.gene.2023.147939. Epub 2023 Oct 29.ABSTRACTThe Lemon shark Negaprion brevirostris is an important species experiencing conservation issues that is in need of genomic resources. Herein, we conducted a genome survey sequencing in N. brevirostris and determined genome size, explored repetitive elements, assembled and annotated the 45S rRNA DNA operon, and assembled and described in detail the mitochondrial genome. Lastly, the phylogenetic position of N. brevirostris in the family Carcharhinidae was examined using translated protein coding genes. The estimated haploid genome size ran...
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: J Antonio Baeza Natalie C Stephens Alyssa Baker Andrew Lyons Bryan Franks Stacy Pirro Kevin A Feldheim Source Type: research
A positive selection at binding site 501 in the B.1 lineage might have triggered the highly infectious sub-lineages of SARS-CoV-2
This study sheds light on the evolutionary trajectory of the B lineage into highly infectious descendants in the recent past under the influence of positive and purifying selection exerted by natural immunity and vaccination of the host.PMID:38575097 | DOI:10.1016/j.gene.2024.148427 (Source: Gene)
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Basant K Tiwary Source Type: research
Splice site recognition - deciphering Exon-Intron transitions for genetic insights using Enhanced integrated Block-Level gated LSTM model
Gene. 2024 Apr 2:148429. doi: 10.1016/j.gene.2024.148429. Online ahead of print.ABSTRACTBioinformatics is a contemporary interdisciplinary area focused on analyzing the growing number of genome sequences. Gene variants are differences in DNA sequences among individuals within a population. Splice site recognition is a crucial step in the process of gene expression, where the coding sequences of genes are joined together to form mature messenger RNA (mRNA). These genetic variants that disrupt genes are believed to be the primary reason for neuro-developmental disorders like ASD (Autism Spectrum Disorder) is a neuro-developm...
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Mohemmed Sha Mohamudha Parveen Rahamathulla Source Type: research
Gene expression patterns of Sirtuin family members (SIRT1 TO SIRT7): Insights into pathogenesis and prognostic of Myelodysplastic neoplasm
Gene. 2024 Apr 3;915:148428. doi: 10.1016/j.gene.2024.148428. Online ahead of print.ABSTRACTTo assess and validate the gene expression profile of SIRTs (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, and SIRT7) in relation to the pathogenesis and prognostic progression of Myelodysplastic neoplasm (MDS). Eighty bone marrow samples of patients with de novo MDS were diagnosed according to WHO 2022 and IPSS-R criteria. Ten bone marrow samples were obtained from elderly healthy volunteers and used as control samples. Gene expression levels of all SIRTs were assessed using RT-qPCR assays. Downregulation of SIRT2 (p = 0.009), SIRT3 (p...
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Jo ão Vitor Caetano Goes Mateus de Aguiar Viana Leticia Rodrigues Sampaio Clarissa Brenda Alves Cavalcante Mayara Magna de Lima Melo Roberta Taiane Germano de Oliveira Daniela de Paula Borges Paola Gyuliane Gon çalves Ronald Feitosa Pinheiro Howard Lope Source Type: research
The vesicle trafficking gene, OsRab7, is critical for pollen development and male fertility in cytoplasmic male-sterility rice
Gene. 2024 Apr 2:148423. doi: 10.1016/j.gene.2024.148423. Online ahead of print.ABSTRACTRice cytoplasmic male sterility (CMS) provides an exceptional model for studying genetic interaction within plant nuclei given its inheritable trait of non-functional male gametophyte. Gaining a comprehensive understanding of the genes and pathways associated with the CMS mechanism is imperative for improving the vigor of hybrid rice agronomically, such as its productivity. Here, we observed a significant decrease in the expression of a gene named OsRab7 in the anther of the CMS line (SJA) compared to the maintainer line (SJB). OsRab7 i...
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Suping Ying Yunting Tang Wei Yang Zhao Hu Ruifeng Huang Jie Ding Xiangyun Yi Jiawei Niu Zihan Chen Ting Wang Wei Liu Xiaojue Peng Source Type: research
Dynamic analysis of SARS-CoV-2 evolution based on different countries
In conclusion, our study not only sheds light on the evolutionary trajectory of SARS-CoV-2 but also underscores the urgency for robust, continuous global data collection and sharing. It highlights the necessity for rapid adaptations in medical countermeasures, including vaccine development, to stay ahead of pathogen evolution. This research provides valuable insights for future pandemic preparedness and response strategies.PMID:38575101 | DOI:10.1016/j.gene.2024.148426 (Source: Gene)
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Binghan Xiao Linhuan Wu Qinlan Sun Chang Shu Songnian Hu Source Type: research
Advances in the evolution research and genetic breeding of peanut
Gene. 2024 Apr 2:148425. doi: 10.1016/j.gene.2024.148425. Online ahead of print.ABSTRACTPeanut is an important cash crop used in oil, food and feed in our country. The rapid development of sequencing technology has promoted the research on the related aspects of peanut genetic breeding. This paper reviews the research progress of peanut origin and evolution, genetic breeding, molecular markers and their applications, genomics, QTL mapping and genome selection techniques. The main problems of molecular genetic breeding in peanut research worldwide include: the narrow genetic resources of cultivated species, unstable genetic...
Source: Gene - April 4, 2024 Category: Genetics & Stem Cells Authors: Hui Zhang Yueyi Tang Yunlai Yue Yong Chen Source Type: research
