Effect of bromodomain PHD-finger transcription factor (BPTF) on trophoblast epithelial-to-mesenchymal transition
In conclusion, BPTF participates in the regulation of trophoblast EMT by activating Slug expression, suggesting that BPTF defects are an important factor in RM pathogenesis.PMID:38521110 | DOI:10.1016/j.gene.2024.148405 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Linqing Pan Fuquan Zhu Aochen Yu Chao Jia Huaiyun Tang Minglian Zhou Mingrui Li Shiwen Jiang Juan Li Yugui Cui Lisha Tang Source Type: research
S100A6 mediated epithelial-mesenchymal transition affects chemosensitivity of colorectal cancer to oxaliplatin
CONCLUSION: In conclusion, the knockdown of S100A6 may overcome the L-OHP resistance of CRC cells by modulating EMT.PMID:38521111 | DOI:10.1016/j.gene.2024.148406 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Chunying Zhang Menglu Zeng Yihan Xu Bihan Huang Pengchong Shi Xianjin Zhu Yingping Cao Source Type: research
Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC
In conclusion, we identified CTBP1-DT as a potential immunological biomarker and discovered the potential role of CTBP1-DT in regulating lipid synthesis and apoptosis resistance.PMID:38521112 | DOI:10.1016/j.gene.2024.148403 (Source: Gene)
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Haolin Li Mintian Fei Yi Zhang Qili Xu Rui Feng Jing Cao Yan Qu Haibing Xiao Source Type: research
Comprehensive identification and analysis of DUF640 genes associated with rice growth
In this study, 61 DUF640 genes were identified in the Oryza genus. The expression of DUF640s is induced by multiple hormonal stressors including abscisic acid (ABA), cytokinin (CK), ethylene (ETH), and indole-3-acetic acid (IAA). Specifically, OiDUF640-10 expression significantly increased after ETH treatment. Transgenic experiments showed that overexpressing OiDUF640-10 lines were sensitive to ETH, and seedling length was obstructed. Evolutionary analysis revealed differentiation of the OiDUF640-10 gene in O. sativa ssp. indica and japonica varieties, likely driven by natural selection during the domestication of cultivat...
Source: Gene - March 23, 2024 Category: Genetics & Stem Cells Authors: Zhikai Wang Ruihua Wang Huanran Yuan Fengfeng Fan Shaoqing Li Mingxing Cheng Zhihong Tian Source Type: research
Genome-wide analysis of LOG family genes in castor and RcLOG5 enhances drought, salt, and cold stress tolerance in Arabidopsis thaliana
This study provides valuable gene resources for breeding stress-tolerant castor bean varieties.PMID:38518901 | DOI:10.1016/j.gene.2024.148398 (Source: Gene)
Source: Gene - March 22, 2024 Category: Genetics & Stem Cells Authors: Yanxiao Li Guishuang Zhu Haonan Sun Dianjun Xiang Chunlan Zhang Zhigang Li Peng Liu Source Type: research
Microarray analysis of tRNA-derived small RNA (tsRNA) in LPS-challenged macrophages treated with metformin
Gene. 2024 Mar 20:148399. doi: 10.1016/j.gene.2024.148399. Online ahead of print.ABSTRACTMetformin, a widely used anti-diabetic drug, has demonstrated its efficacy in addressing various inflammatory conditions. tRNA-derived small RNA (tsRNA), a novel type of small non-coding RNA, exhibits diverse regulatory functions and holds promise as both a diagnostic biomarker and a therapeutic target for various diseases. The purpose of this study is to investigate whether the abundance of tsRNAs changed in LPS versus LPS + metformin-treated cells, utilizing microarray technology. Firstly, we established an in vitro lipopolysaccharid...
Source: Gene - March 22, 2024 Category: Genetics & Stem Cells Authors: Huan Lin Hongao Deng Zhengying Jiang Peng Hua Shiqiang Hu Haiyong Ao Meiling Zhong Mingzhuo Liu Guanghua Guo Source Type: research
Association between polymorphisms and atopic dermatitis susceptibility: A systematic review and meta-analysis
CONCLUSIONS: Nine SNPs that may be risk factors and one SNP that may be a protective factor for AD were identified, providing a reference for AD prediction, prevention, and therapy.PMID:38513928 | DOI:10.1016/j.gene.2024.148397 (Source: Gene)
Source: Gene - March 21, 2024 Category: Genetics & Stem Cells Authors: Yunxia Huang Wei Zhou Shunan Liu Dan Zeng Weikang Zhou Source Type: research
Association between polymorphisms and atopic dermatitis susceptibility: A systematic review and meta-analysis
CONCLUSIONS: Nine SNPs that may be risk factors and one SNP that may be a protective factor for AD were identified, providing a reference for AD prediction, prevention, and therapy.PMID:38513928 | DOI:10.1016/j.gene.2024.148397 (Source: Gene)
Source: Gene - March 21, 2024 Category: Genetics & Stem Cells Authors: Yunxia Huang Wei Zhou Shunan Liu Dan Zeng Weikang Zhou Source Type: research
miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes
CONCLUSIONS: Modulation of H3K27me3 methylation in differentiated HepaRG cells, by GSK-J4 treatment, influenced miRNA' s expression profile pushing liver cells towards a proliferating phenotype. We demonstrated the involvement of miR-27a-3p in reinducing proliferation of differentiated hepatocytes suggesting a potential role in liver plasticity.PMID:38499211 | DOI:10.1016/j.gene.2024.148387 (Source: Gene)
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Debora Salerno Giovanna Peruzzi None Giuseppe Rubens Pascucci Massimo Levrero Laura Belloni Natalia Pediconi Source Type: research
Mitochondrial genes modulate the phenotypic expression of congenital scoliosis syndrome caused by mutations in the TBXT gene
CONCLUSION: We described the possible role of mtDNA genetics on the pathogenesis of congenital scoliosis by hypothesizing that the presence of the homozygous variant in TBXT accounts for the CS phenotype in our patient and the MT-ND3 gene may act as a modifier gene.PMID:38499212 | DOI:10.1016/j.gene.2024.148388 (Source: Gene)
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Olfa Alila-Fersi Amel Tej Marwa Maalej Marwa Kharrat Lamia Boughamoura Jihen Chouchen Abdelaziz Tlili Faiza Fakhfakh Source Type: research
ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis
This study highlights the importance of ChaC1 in cancer prognosis across a wide variety of cancers. Additionally, the information on the SNPs of ChaC1 with altered enzymatic activities would improve the prognostic ability of these panels and facilitate treatment regimens.PMID:38499213 | DOI:10.1016/j.gene.2024.148386 (Source: Gene)
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Devraj Parande Shradha Suyal Anand K Bachhawat Source Type: research
Functional relevance of MMP2 promoter variants in gallbladder cancer: A case-control study in an Eastern Indian Population
This study aimed to investigate the genetic factors contributing to the high incidence of GBC in certain geographical regions, particularly in the Northern and Eastern parts of India. The present case-control study focused on MMP2, a gene involved in tumor progression and metastasis, as a potential candidate in GBC pathogenesis. We scanned MMP2 promoter for twelve SNPs using Sanger's sequencing and carried out a case-control study in 300 cases and 300 control samples. We found five rare variants (rs1961998763, rs1961996235, rs1391392808, rs1488656253, and rs17859816) and one nonpolymorphic SNP (rs17859817). Our results rev...
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Vinay Jeeyar Shivaram Prasad Singh Manjusha Dixit Source Type: research
miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes
CONCLUSIONS: Modulation of H3K27me3 methylation in differentiated HepaRG cells, by GSK-J4 treatment, influenced miRNA' s expression profile pushing liver cells towards a proliferating phenotype. We demonstrated the involvement of miR-27a-3p in reinducing proliferation of differentiated hepatocytes suggesting a potential role in liver plasticity.PMID:38499211 | DOI:10.1016/j.gene.2024.148387 (Source: Gene)
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Debora Salerno Giovanna Peruzzi None Giuseppe Rubens Pascucci Massimo Levrero Laura Belloni Natalia Pediconi Source Type: research
Mitochondrial genes modulate the phenotypic expression of congenital scoliosis syndrome caused by mutations in the TBXT gene
CONCLUSION: We described the possible role of mtDNA genetics on the pathogenesis of congenital scoliosis by hypothesizing that the presence of the homozygous variant in TBXT accounts for the CS phenotype in our patient and the MT-ND3 gene may act as a modifier gene.PMID:38499212 | DOI:10.1016/j.gene.2024.148388 (Source: Gene)
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Olfa Alila-Fersi Amel Tej Marwa Maalej Marwa Kharrat Lamia Boughamoura Jihen Chouchen Abdelaziz Tlili Faiza Fakhfakh Source Type: research
ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis
This study highlights the importance of ChaC1 in cancer prognosis across a wide variety of cancers. Additionally, the information on the SNPs of ChaC1 with altered enzymatic activities would improve the prognostic ability of these panels and facilitate treatment regimens.PMID:38499213 | DOI:10.1016/j.gene.2024.148386 (Source: Gene)
Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Devraj Parande Shradha Suyal Anand K Bachhawat Source Type: research
