miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes

CONCLUSIONS: Modulation of H3K27me3 methylation in differentiated HepaRG cells, by GSK-J4 treatment, influenced miRNA' s expression profile pushing liver cells towards a proliferating phenotype. We demonstrated the involvement of miR-27a-3p in reinducing proliferation of differentiated hepatocytes suggesting a potential role in liver plasticity.PMID:38499211 | DOI:10.1016/j.gene.2024.148387

Source: Gene - March 18, 2024 Category: Genetics & Stem Cells Authors: Debora Salerno Giovanna Peruzzi None Giuseppe Rubens Pascucci Massimo Levrero Laura Belloni Natalia Pediconi Source Type: research