Adiposity and body mass index of young women are associated with altered 24-hour profile of wrist temperature and sleep quality.
ras T Abstract Sleep alterations are linked to circadian disturbances; however, these variables are also related with adiposity, which could impair the study of the previous relationship. Here, we investigated whether the association between adiposity and impaired circadian health is independent of sleep and circadian related variables in a sample of young women. One hundred ninety-two women (18-30 years of age) participated in this cross-sectional study. To evaluate circadian rhythmicity, subjects wore a temperature sensor for six consecutive days, and variables related with the amplitude and stability of th...
Source: Chronobiology International - July 31, 2020 Category: Biology Authors: Zerón-Rugerio MF, Diez-Noguera A, Izquierdo-Pulido M, Cambras T Tags: Chronobiol Int Source Type: research

Age-dependent altered redox homeostasis in the chronodisrupted rat model and moderation by melatonin administration.
This study was conducted on young (3 months) and old (24 months) male Wistar rats subdivided into four groups control (C), melatonin treated (MLT), artificial light at night (ALAN), and ALAN+MLT group. Pronounced changes were observed in the old compared to the young rats. Reactive oxygen species (ROS), malondialdehyde (MDA), plasma membrane redox system (PMRS), protein carbonyl (PCO), and sialic acid (SA) were significantly (p ≤ 0.05) increased, while ferric reducing ability of plasma (FRAP) and reduced glutathione (GSH) were significantly (p ≤ 0.05) suppressed in light-exposed young an...
Source: Chronobiology International - July 30, 2020 Category: Biology Authors: Verma AK, Singh S, Rizvi SI Tags: Chronobiol Int Source Type: research

Working time dimensions and well-being: a cross-national study of Finnish and German health care employees.
el A, Oksanen T Abstract Health care professionals often face irregular working hours and high work pace. We studied associations of the five working time dimensions duration (weekly working hours), timing (shift work and weekend work), on-call work, working time autonomy, and work tempo (deadline and performance pressure) with well-being among health care employees in Finland and Germany. We used data on working time dimensions and indicators of well-being (work-life conflict, poor perceived health, sleep difficulties, and fatigue) from a cohort of 5050 hospital employees (Working Hours in the Finnish Public Sect...
Source: Chronobiology International - July 29, 2020 Category: Biology Authors: Karhula K, Wöhrmann AM, Brauner C, Härmä M, Kivimäki M, Michel A, Oksanen T Tags: Chronobiol Int Source Type: research

Novel perspectives on the influence of the lunar cycle on the timing of full-term human births.
Abstract It is claimed by some that the number of births occurring at the time of the full moon is greater than other phases of the lunar cycle; however, many publications fail to substantiate the claim leading to the conclusion it is myth. We tested using a novel approach the null hypotheses: (i) human birth is not lunar cycle-dependent and (ii) the number of births occurring at or around the time of the full moon is not different from the number occurring at the time of the other phases of the lunar cycle. We reviewed the birth records from 1 January 1996 to 16 March 2007 of the obstetric department of our hospi...
Source: Chronobiology International - July 23, 2020 Category: Biology Authors: Matsumoto SI, Shirahashi K Tags: Chronobiol Int Source Type: research

Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial.
ón A Abstract The main purpose of this commentary is to update, based on our extensive review of the published literature of the past 45 yrs, the differential therapeutic effects of hypertension medications of various classes and their combinations when ingested in the evening/at-bedtime versus in the morning/upon-awakening. Interestingly, revision of the currently available evidence on the differential circadian-time-dependent effects of hypertension medications of six different classes and their combinations indicates among the 137 published hypertension medication trials that evaluated blood pressur...
Source: Chronobiology International - July 20, 2020 Category: Biology Authors: Hermida RC, Fernández JR, Mojón A Tags: Chronobiol Int Source Type: research

Blood pressure medication should be routinely dosed at bedtime. An internist's critical appraisal of the editorial by Rainhold Kreutz et al. (2020). Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Pressure. 29 (3):135-136.
Abstract The history of hypertension the past hundred years is a successful story of the fall of myths, beliefs, and assumptions under the weight of evidence. The recent editorial by Kreutz et al. (2020),"Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project", published in Blood Pressure, conveys unjustified concerns founded on baseless doubts and suspicions about the Hygia Chronotherapy Trial. The physicians of Portugal are beginning to incorporate into routine clinical practice the proven methods of the Hygia Chronotherapy Trial - 48-hour ...
Source: Chronobiology International - July 20, 2020 Category: Biology Authors: Machado AP Tags: Chronobiol Int Source Type: research

Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial.
Hermida RC Abstract The specific purpose of this communication is to summarize the relevant details of the methods utilized to conduct, analyze, and interpret the ambulatory blood pressure (BP) monitoring (ABPM)-obtained patient data in both MAPEC and Hygia Chronotherapy Trial, including details of the sampling requirements in terms of duration and frequency, proper calculation of ABPM-derived mean values, prognostic and therapeutic implications of BP dipping, and limitations of the 24 h BP mean as diagnostic/prognostic parameter still mistakenly recommended by some hypertension guidelines. PMID: 326840...
Source: Chronobiology International - July 20, 2020 Category: Biology Authors: Fernández JR, Mojón A, Hermida RC Tags: Chronobiol Int Source Type: research

The Hygia Project and Hygia Chronotherapy Trial: insights of we clinical investigators on the impact of the embedded continuing medical education on primary-care practice and improved patient cardiovascular health.
ado JL, Durán C, Sánchez JJ Abstract The participating doctors of the Hygia Chronotherapy Trial (HCT) are aware of the criticisms of its published findings, which have been unjustifiably misrepresented in letters to the editors and commentaries, perhaps because of lack of understanding of the foundations of the Hygia Project, in which the HCT is nested. Thus, our purpose through this communication is to highlight the unique features of the Hygia Project and HCT in terms of: (i) organization, management, and quality control, (ii) physician training/continuing medical education, and (iii) impact on eve...
Source: Chronobiology International - July 20, 2020 Category: Biology Authors: Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ Tags: Chronobiol Int Source Type: research

Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials.
ute;ndez JR Abstract The purpose of this communication is to describe the unique features of the investigative protocols of both MAPEC and Hygia Chronotherapy Trial and to discuss in detail the advantages, limitations, and potential implications of their findings, both for the diagnosis and management of true arterial hypertension that we propose must be defined according to ambulatory blood pressure monitoring (ABPM)-based criteria. In particular, the recommended approach for diagnosis and follow-up of hypertension derived from the findings of MAPEC and Hygia Chronotherapy Trial entails baseline 48-h ABPM assessm...
Source: Chronobiology International - July 20, 2020 Category: Biology Authors: Hermida RC, Mojón A, Fernández JR Tags: Chronobiol Int Source Type: research

Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials.
z JJ, Mojón A, Fernández JR, Hermida RC Abstract Reinhold Kreutz and colleagues in a recent editorial claim the Hygia Chronotherapy Trial lacks credibility because of deficient methods, thereby dismissing both the plausibility and clinical significance of its reported findings. They misstate and misrepresent crucial information, findings and conclusions unambiguously detailed in the published report of the Hygia Chronotherapy Trial. The purpose of this communication is to provide a complete rebuttal to each and every one of the misleading and scientifically unsupported claims by Kreutz et al. that ca...
Source: Chronobiology International - July 20, 2020 Category: Biology Authors: Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, Salgado JL, Durán C, Sánchez JJ, Mojón A, Fernández JR, Hermida RC Tags: Chronobiol Int Source Type: research

Diurnal gait fluctuations in single- and dual- task conditions.
Abstract Gait is one of the most basic movements, and walking activity accomplished in dual task conditions realistically represents daily life mobility. Much is known about diurnal variations of gait components such as muscle power, postural control, and attention. However, paradoxically only little is known about gait itself. The aim of this study was to analyze whether gait parameters show time-of-day fluctuation in simple and dual task conditions. Sixteen young subjects performed sessions at five specific hours (06:00, 10:00, 14:00, 18:00 and 22:00 h), performing a single (walking or counting) and a dual ...
Source: Chronobiology International - July 14, 2020 Category: Biology Authors: Bessot N, Polyte R, Quesney M, Bulla J, Gauthier A Tags: Chronobiol Int Source Type: research

Sex differences in the effects of the moon on ischemic stroke incidence: new findings from Beijing, China.
Abstract Stroke is a major cause of death and disability in China, and no therapies have proven effective to prevent it. Popular belief holds that the lunar cycle affects human physiology, behavior, and health. The aim of our study is to determine whether the lunar cycle impacts the incidence of stroke subtypes [intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and ischemic stroke (IS)]. We retrospectively extracted the discharge registry data of all patients with first-ever acute stroke hospitalized in the affiliated hospital of Beijing University of Traditional Chinese Medicine during 2002-2015. Th...
Source: Chronobiology International - July 13, 2020 Category: Biology Authors: Wang RR, Hao Y, Chen J, Wang MQ, Zheng RY, Shi LS, He J Tags: Chronobiol Int Source Type: research

Development of model based on clock gene expression of human hair follicle cells to estimate circadian time.
Abstract Considering the effects of circadian misalignment on human pathophysiology and behavior, it is important to be able to detect an individual's endogenous circadian time. We developed an endogenous Clock Estimation Model (eCEM) based on a machine learning process using the expression of 10 circadian genes. Hair follicle cells were collected from 18 healthy subjects at 08:00, 11:00, 15:00, 19:00, and 23:00 h for two consecutive days, and the expression patterns of 10 circadian genes were obtained. The eCEM was designed using the inverse form of the circadian gene rhythm function (i.e., Circadian Time&nb...
Source: Chronobiology International - July 13, 2020 Category: Biology Authors: Lee T, Cho CH, Kim WR, Moon JH, Kim S, Geum D, In HP, Lee HJ Tags: Chronobiol Int Source Type: research

Associations between shift work and risk of colorectal cancer in two German cohort studies.
In conclusion, night-shift work was not associated with CRC, although an increased risk was suggested for rotating shift work including nights in SHIP. The heterogeneity of shift-work jobs and schedules and associated lifestyle factors should be taken into account to disentangle a possible relationship between shift work and the risk for CRC in future investigations. PMID: 32654542 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - July 13, 2020 Category: Biology Authors: Wichert K, Rabstein S, Stang A, Erbel R, Eisele L, Arendt M, Keimer A, Dragano N, Hoffmann W, Lerch MM, Roskoden FC, Schmidt CO, Völzke H, Jöckel KH, Brüning T, Behrens T Tags: Chronobiol Int Source Type: research

Comparison of Munich Chronotype Questionnaire (MCTQ) and Morningness-Eveningness Questionnaire (MEQ) Czech version.
In this study, we created the Czech version of the MCTQ and examined its relationship with the Czech version of MEQ, including socio-demographic effects. We also examined the ability of the MCTQ to identify chronotypes and cutoffs for their determination. In total, 2703 people (1964 females, 739 males, 18-75 years of age) were screened by the MEQ, MCTQ and reported on age, sex and self-declared body mass index (BMI). We found a significant relationship (p
Source: Chronobiology International - July 13, 2020 Category: Biology Authors: Fárková E, Novák JM, Manková D, Kopřivová J Tags: Chronobiol Int Source Type: research

COVID-19 pandemic and lockdown: cause of sleep disruption, depression, somatic pain, and increased screen exposure of office workers and students of India.
Abstract COVID-19 has brought the world into uncharted waters. Many countries are under lockdown, the economy has ground to a halt, and almost everyone is afraid of dire consequences. The unprecedented changes that came on so quickly due to the pandemic and stay-at-home confinement to accomplish social distancing and mitigate risk for infection pose many challenges. These include compromised health, well-being, and sleep as a consequence of disruption of the daily life routine, anxiety, worry, isolation, greater family and work stress, and excessive screen time. Our study of 203 corporate sector professionals perf...
Source: Chronobiology International - July 13, 2020 Category: Biology Authors: Majumdar P, Biswas A, Sahu S Tags: Chronobiol Int Source Type: research

Blue light emission spectra of popular mobile devices: The extent of user protection against melatonin suppression by built-in screen technology and light filtering software systems.
This study evaluated the efficiency of the blue light screen and control software technologies of eight different mobile devices. Emitted screen spectra of the different mobile devices according to different conditions of blue light emission software control were obtained using a spectrograph, and the derived spectra were compared with the melatonin suppression action spectrum. The amount of blue light emission and predicted melatonin suppression varied according to the unique software control and screen technology of each device. AMOLED screen technology, compared with other screen technologies, achieved better control of...
Source: Chronobiology International - July 10, 2020 Category: Biology Authors: Calvo-Sanz JA, Tapia-Ayuga CE Tags: Chronobiol Int Source Type: research

Chronotype and depressive symptoms in healthy subjects: the mediating role of hopelessness and subjective sleep quality.
;cens B Abstract Chronotype preference and lower sleep quality in university students can influence mental health. Individuals with evening chronotypes have a high risk of mental health problems, including depressive symptoms. However, the underlying mechanisms are still under investigation. Hopelessness is composed of negative feelings and thoughts about the future and is closely related to depressive symptomatology. The aim of the study was to determine whether reduced sleep quality and hopelessness mediate the association between chronotype and depressive symptoms in a student sample, which was evaluated cross-...
Source: Chronobiology International - July 8, 2020 Category: Biology Authors: Üzer A, Yücens B Tags: Chronobiol Int Source Type: research

Temporal flexibility in activity rhythms of a diurnal rodent, the ice rat (Otomys sloggetti).
Abstract Diurnality in rodents is relatively rare and occurs primarily in areas with low nighttime temperatures such as at high altitudes and desert areas. However, many factors can influence temporal activity rhythms of animals, both in the field and the laboratory. The temporal activity patterns of the diurnal ice rat were investigated in the laboratory with, and without, access to running wheels, and in constant conditions with running wheels. Ice rats appeared to be fundamentally diurnal but used their running wheels during the night. In constant conditions, general activity remained predominantly diurnal whil...
Source: Chronobiology International - July 7, 2020 Category: Biology Authors: Oosthuizen MK Tags: Chronobiol Int Source Type: research

Crosstalk between circulating microRNAs and chronotypical features in subjects with metabolic syndrome.
In conclusion, we identified four circulating miRNAs whose circulating levels could interact with MetS and chronotype. PMID: 32633152 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - July 7, 2020 Category: Biology Authors: Assmann TS, Cuevas-Sierra A, Salas-Pérez F, Riezu-Boj JI, Milagro FI, Martínez JA Tags: Chronobiol Int Source Type: research

COVID-19 and "natural" experiments arising from physical distancing: a hypothetical case study from chronobiology.
COVID-19 and "natural" experiments arising from physical distancing: a hypothetical case study from chronobiology. Chronobiol Int. 2020 Jul 07;:1-3 Authors: Erren TC, Lewis P, Shaw DM Abstract With countless "natural" experiments triggered by the COVID-19-associated physical distancing, one key question comes from chronobiology: "When confined to homes, how does the reduced exposure to natural daylight arising from the interruption of usual outdoor activities plus lost temporal organization ordinarily provided from workplaces and schools affect the circadian timing system (the...
Source: Chronobiology International - July 7, 2020 Category: Biology Authors: Erren TC, Lewis P, Shaw DM Tags: Chronobiol Int Source Type: research

Sleep quality and quantity in Italian University students: an actigraphic study.
Abstract According to international recommendations, young adults should sleep at least 7 h per night and experience good sleep quality to avoid physical and mental health problems. University students are particularly exposed to the risk of sleep issues due to their tendency to go to bed late at night and other social and environmental factors. Here, we aimed to objectively characterize the weekly sleep habits using actigraphy (in terms of quantity, quality, and timing) in 82 Italian university students (mean age = 23.89, SD = 2.51 yrs, 44 women). Exploratory analyses were performed ...
Source: Chronobiology International - July 6, 2020 Category: Biology Authors: Cellini N, Menghini L, Mercurio M, Vanzetti V, Bergamo D, Sarlo M Tags: Chronobiol Int Source Type: research

Obituary: Pietro Cugini (13 December 1936 - 6 April 2020).
Abstract Chronobiology lost a great and distinguished physician-scientist, Pietro Cugini (Figure 1). He will be dearly missed by his family, his friends, and the field he helped shape and guide as he remained active until the end of his life at 83 years of age. In the middle of the worst pandemic the world has known in recent times, but not from COVID-19, Pietro passed away unexpectedly in front of his Rome apartment, on Via Latina, the same street where he was born and where he spent most of his life. He was buried shortly afterward in the Monumental cemetery of Marino. There was no formal ceremony as funera...
Source: Chronobiology International - July 2, 2020 Category: Biology Authors: Cornelissen G, Sothern RB, Sackett-Lundeen L, Uezono K, Otsuka K Tags: Chronobiol Int Source Type: research

The circadian disruption of night work alters gut microbiota consistent with elevated risk for future metabolic and gastrointestinal pathology.
Abstract Day and night cycles are the most important cue for the central clock of human beings, and they are also important for the gut clock. The aim of the study is to determine the differences in the gut microbiota of rotational shift workers when working the day versus night shift. Fecal samples and other data were collected from 10 volunteer male security officers after 4 weeks of day shift work (07:00-15:00 h) and also after 2 weeks of night shift work (23:00-07:00 h). In total, 20 stool samples were collected for analysis of gut microbiota (10 subjects x 2 work shifts) and stored at -80&...
Source: Chronobiology International - June 30, 2020 Category: Biology Authors: Mortaş H, Bilici S, Karakan T Tags: Chronobiol Int Source Type: research

Rest-activity rhythms, daytime symptoms, and functional performance among people with heart failure.
Abstract Sleep disturbance and decreased daytime activity are well-described among people with chronic heart failure (HF) who suffer from disabling daytime symptoms and poor function. Alterations in the circadian rhythmicity of rest-activity may also be associated with these outcomes. However, little is known about the associations between rest-activity rhythms (RARS), symptoms, and functional performance or the extent to which they are explained by sleep characteristics among people with HF. The purpose of this study is to evaluate parametric and non-parametric circadian characteristics of RARs and the associatio...
Source: Chronobiology International - June 26, 2020 Category: Biology Authors: Jeon S, Conley S, Redeker NS Tags: Chronobiol Int Source Type: research

Absorption of glucosamine is improved by considering circadian rhythm and feeding time in rats.
In conclusion, the pharmacokinetics of GlcN was improved by considering not only food intake but also the circadian rhythm of its transporter, which is a major factor influencing pharmacokinetic changes. PMID: 32576047 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - June 24, 2020 Category: Biology Authors: Seto Y, Yoshihashi T, Tomonari M, To H Tags: Chronobiol Int Source Type: research

Environmental temperature as a mediator on the association between photoperiod at birth and chronotype.
de TG Abstract The association between chronotypes and season of birth (SOB) remains an inconclusive issue due, in some extension, to the lack of investigations of mediation mechanisms. We evaluated the association of photoperiod at birth (PAB) with chronotypes and sleep duration in Brazil (n = 810), and the mediating effect of meteorological factors, sex, age and rs4753426 polymorphism in the melatonin receptor MTNR1B. Longer PAB was associated with a delayed mid-sleep phase with a suppressive effect of maximum environmental temperature. No significant interactions were identified for the other variable...
Source: Chronobiology International - June 23, 2020 Category: Biology Authors: Santos RC, Silva ACPE, Santos MJD, Barbosa MR, Coimbra DG, Gitaí DLG, de Andrade TG Tags: Chronobiol Int Source Type: research

Aging-related changes on social synchronization of circadian activity rhythm in a diurnal primate (Callithrix jacchus).
Azevedo CVM Abstract The input of environmental time cues and expression of circadian activity rhythms may change with aging. Among nonphotic zeitgebers, social cues from conspecific vocalizations may contribute to the stability and survival of individuals of social species, such as nonhuman primates. We evaluated aging-related changes on social synchronization of the circadian activity rhythm (CAR) in a social diurnal primate, the common marmoset. The activity of 18 male marmosets was recorded by actiwatches in two conditions. (1) Experimental - 4 young adult (5 ± 2 yrs of age) and 4 older (...
Source: Chronobiology International - June 23, 2020 Category: Biology Authors: Gonçalves FB, Gonçalves BSB, Cavalcante JS, Azevedo CVM Tags: Chronobiol Int Source Type: research

Is disruption of sleep quality a consequence of severe Covid-19 infection? A case-series examination.
Abstract The Covid-19 outbreak put enormous stress on the health system worldwide, and objective data to handle the emergency are still needed. We aimed to objectively assess the consequence of severe symptoms of Covid-19 infection on sleep quality through wrist actigraphy monitoring of four patients during the sub-acute recovery stage of the disease. The sleep of those patients who had experienced the most severe respiratory symptoms and who had needed prolonged intensive care unit (ICU) stay showed lower Sleep Efficiency and Immobility Time and higher Fragmentation Index compared to those patients who had experi...
Source: Chronobiology International - June 23, 2020 Category: Biology Authors: Vitale JA, Perazzo P, Silingardi M, Biffi M, Banfi G, Negrini F Tags: Chronobiol Int Source Type: research

Effects of altered photoperiod due to COVID-19 lockdown on pregnant women and their fetuses.
This article summarizes the potential effects on pregnant woman and their fetuses due to prolonged exposure to altered photoperiod and as consequence altered circadian system, known as chronodisruption, that may result from the COVID-19 lockdown. PMID: 32519912 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - June 10, 2020 Category: Biology Authors: Bagci S, Sabir H, Müller A, Reiter RJ Tags: Chronobiol Int Source Type: research

Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death.
Early dinner or "dinner like a pauper": Evidence, the habitual time of the largest meal of the day - dinner - is predisposing to severe COVID-19 outcome - death. Chronobiol Int. 2020 Jun 09;:1-5 Authors: Verd S, Beiro S, Fernandez-Bernabeu M, Ponce-Taylor J Abstract COVID-19 and metabolic syndrome are devastating pandemics. Effective control of metabolic parameters and their dysfunction may help prevent or minimize the acute and devastating effects of SARS-CoV-2 by reducing the local inflammatory response and blocking the entry of the virus into cells. With such consideration in mind, we gat...
Source: Chronobiology International - June 9, 2020 Category: Biology Authors: Verd S, Beiro S, Fernandez-Bernabeu M, Ponce-Taylor J Tags: Chronobiol Int Source Type: research

COVID-19 infection at nighttime.
PMID: 32511019 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - June 8, 2020 Category: Biology Authors: Fujimura A, Ushijima K, Smolensky MH Tags: Chronobiol Int Source Type: research

SARS-CoV-2/COVID-19 and physical distancing: risk for circadian rhythm dysregulation, advice to alleviate it, and natural experiment research opportunities.
Abstract SARS-CoV-2/COVID-19 leads to numerous unplanned or natural experiments with health and disease. Physical (social) distancing - a counter-measure with no alternative, but with no precedence in scope and scale either - is a key intervention and trigger of natural experiments. From a practical perspective, concerned disciplines should increase awareness of, provide recommendations to meet, and develop research for, health challenges arising from physical distancing at home. From the field of chronobiology, prolonged home stays may place undue strain on the body's circadian timing system but straightforward a...
Source: Chronobiology International - June 5, 2020 Category: Biology Authors: Erren TC, Lewis P Tags: Chronobiol Int Source Type: research

Twenty-four-hour rhythm patterns of plasma melatonin in short-day and long-day breeders maintained under natural environmental conditions.
In conclusion, features of the 24 h rhythm of melatonin among species; however, the 24 h rhythmicity of melatonin each species showed high stability within the various subjects and within the same subject. These findings must be taken into consideration when applying photoperiod and melatonin treatments for breeding purposes. PMID: 32482096 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - June 2, 2020 Category: Biology Authors: Giannetto C, Carcangiu V, Luridiana S, Parmeggiani A, Piccione G Tags: Chronobiol Int Source Type: research

Seasonality in pain, sleep and mental distress in patients with chronic musculoskeletal pain at latitude 69 ° N.
We examined seasonal variation in pain severity and pain dissemination, as well as in pain-associated conditions, such as sleep impairment, sleep timing, mental distress, fatigue and physical activity. We also examined if any of these associated conditions moderated the seasonality in pain. This prospective study was conducted in the subarctic municipality of Tromsø, Norway (69º North), on a sample of patients with chronic musculoskeletal pain (N = 56). Data were collected with self-report questionnaires and objective actigraphy measures (7 days) twice: winter and summer. Mixed linear regression model...
Source: Chronobiology International - May 28, 2020 Category: Biology Authors: Abeler K, Sand T, Friborg O, Bergvik S Tags: Chronobiol Int Source Type: research

Night shift work and osteoporosis among female blue-collar workers in Poland - a pilot study.
Abstract Osteoporosis is an important public health problem worldwide. Although a number of factors that affect bone structure have been described; thus far, the current knowledge of occupational factors that may have an influence on bone tissue metabolism is strongly limited. Published studies indicate night shift work and the related circadian rhythm disruption may be considered as plausible underlying factors. The aim of the present study was to assess the potential association between night shift work and bone mineral density (BMD) among female blue-collar workers in Poland. A cross-sectional study was carried...
Source: Chronobiology International - May 26, 2020 Category: Biology Authors: Bukowska-Damska A, Skowronska-Jozwiak E, Kaluzny P, Lewinski A, Peplonska B Tags: Chronobiol Int Source Type: research

Angry night birds: Emotionality, activity and sociability temperament in adolescent chronotypes.
This study aimed to analyze the domains of emotionality, activity and sociability (EAS) temperament in relation to morningness-eveningness in adolescents. A sample of 539 school pupils aged 13-19 years completed the EAS Temperament Survey, the Composite Scale of Morningness and the Munich Chronotype Questionnaire. Amongst the five EAS domains (emotionality-distress, emotionality-fearfulness, emotionality-anger, activity and sociability), greater emotionality-anger was related to eveningness, while greater emotionality-distress was related to lower social jet lag. The results suggest that evening chronotypes can be tem...
Source: Chronobiology International - May 22, 2020 Category: Biology Authors: Jankowski KS, Linke M Tags: Chronobiol Int Source Type: research

Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Abstract Rotating and permanent night shiftwork schedules typically result in acute and sometimes chronic sleep deprivation plus acute and sometimes chronic disruption of the circadian time structure. Immune system processes and functionalities are organized as circadian rhythms, and they are also strongly influenced by sleep status. Sleep is a vital behavioral state of living beings and a modulator of immune function and responsiveness. Shiftworkers show increased risk for developing viral infections due to possible compromise of both innate and acquired immunity responses. Short sleep and sleep loss, common cons...
Source: Chronobiology International - May 20, 2020 Category: Biology Authors: Silva FRD, Guerreiro RC, Andrade HA, Stieler E, Silva A, de Mello MT Tags: Chronobiol Int Source Type: research

A commentary on the Spanish hypertension studies MAPEC and HYGIA.
Abstract The recently published chronotherapeutic Spanish papers MAPEC and HYGIA proposing that antihypertensive drug treatment should be given at bedtime suffers from obvious deficiencies in study design and are not a valid basis for drug treatment of hypertension. PMID: 32419504 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - May 18, 2020 Category: Biology Authors: Lemmer B, Middeke M Tags: Chronobiol Int Source Type: research

Melatonin and alcohol-related disorders.
Abstract This review concerns the current knowledge of melatonin and alcohol-related disorders. Chronobiological effects of ethanol are related to melatonin suppression and in relation to inflammation, stress, free radical scavenging, autophagy and cancer risk. It is postulated that both alcohol- and inflammation-induced production of reactive oxygen species (ROS) alters cell membrane properties leading to tissue dysfunction and, subsequent further ROS production. Lysosomal enzymes are often used to assess the relationships between intensified inflammation states caused by alcohol abuse and oxidative stress as wel...
Source: Chronobiology International - May 18, 2020 Category: Biology Authors: Kurhaluk N, Tkachenko H Tags: Chronobiol Int Source Type: research

Discovery of the indicator role of period 2 in yellow catfish (Pelteobagrus fulvidraco) food intake during early life development stages.
Abstract The early development stages of fish are a highly ordered and tightly regulated, involving many circadian rhythm-related gene and protein processes. Nonetheless, there are few reports on the effects of circadian clock genes on the early development stages of fish. We studied Pelteobagrus fulvidraco Period 2 (Pf-Per 2) gene structures and expression patterns during the early life stages of development, including the fertilized embryo, yolk absorption, preliminary food, rotifer breeding, and mixed food stages. cDNA of Pf-Per 2 is 4593 bp in length, with 357 bp 5'-untranslated region (5'UTR), 216&n...
Source: Chronobiology International - May 15, 2020 Category: Biology Authors: Fang DA, Yang XJ, Zhou YF, Xu DP, Yang Y, Qin C Tags: Chronobiol Int Source Type: research

Preoperative circadian physical activity rhythm and postoperative delirium in cardiovascular surgery patients.
Abstract Postoperative delirium, a common perioperative complication, is frequently observed in elderly surgical patients. Few studies have investigated the life rhythm of preoperative patients, and whether or not the preoperative life rhythm is associated with the development of postoperative delirium. The purpose of this study was to investigate the relationship between the preoperative circadian physical activity rhythm and postoperative delirium in cardiovascular surgery patients. A total of 43 patients who underwent cardiovascular surgery were included in this prospective study between July 2016 and September...
Source: Chronobiology International - May 14, 2020 Category: Biology Authors: Tan C, Saito N, Miyawaki I, Shiotani H Tags: Chronobiol Int Source Type: research

Associations of chronotype, Big Five, and emotional competences with perceived stress in university students.
This study aimed to investigate the associations between individual difference factors (chronotype, Big Five, emotional competences) and perceived stress in French university students. In total, 362 students agreed to take part (Mage = 20.19 ± 1.75 years). Participants completed the Caen Chronotype Questionnaire, Big Five Inventory, the Profile of Emotional Competences, and the Perceived Stress Scale. Results showed that chronotype amplitude (+), eveningness chronotype (+), neuroticism (+), conscientiousness (-), and intrapersonal emotional competences (-) were important for perceived stress...
Source: Chronobiology International - May 13, 2020 Category: Biology Authors: You M, Laborde S, Dosseville F, Salinas A, Allen MS Tags: Chronobiol Int Source Type: research

Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet.
Abstract Altered circadian rhythms have negative consequences on health and behavior. Emerging evidence suggests genetics influences the physiological and behavioral responses to circadian disruption. We investigated the effects of a 21 h day (T = 21 cycle), with high-fat diet consumption, on locomotor activity, explorative behaviors, and health in male C57BL/6J and C57BL/6N mice. Mice were exposed to either a T = 24 or T = 21 cycle and given standard rodent chow (RC) or a 60% high-fat diet (HFD) followed by behavioral assays and physiological measures. We uncovered numerous strain di...
Source: Chronobiology International - May 13, 2020 Category: Biology Authors: Maroni MJ, Capri KM, Arruda NL, Gelineau RR, Deane HV, Concepcion HA, DeCourcey H, Monteiro De Pina IK, Cushman AV, Chasse MH, Logan RW, Seggio JA Tags: Chronobiol Int Source Type: research

Who is happier among preclinical medical students: the impact of chronotype preference.
Abstract Most studies and systematic reviews of the psychological health of medical students have investigated the negative aspects of depression and anxiety. Evidence from several studies suggests depressive symptoms are common in medical school students. Moreover, evening chronotype is considered a risk factor for the development of depression. However, surprisingly no study has assessed the possible relationship between chronotypes and happiness. The aims of this study were to: (a) assess happiness and its predictors among Turkish preclinical medical students, (b) identify chronotype preferences, and (c) determ...
Source: Chronobiology International - May 12, 2020 Category: Biology Authors: Tan MN, Mevsim V, Pozlu Cifci M, Sayan H, Ercan AE, Ergin OF, Oksuz U, Ensari S Tags: Chronobiol Int Source Type: research

Effect of nocturnal melatonin intake on cellular damage and recovery from repeated sprint performance during an intensive training schedule.
In conclusion, nocturnal melatonin supplementation during an intensive TC alleviated oxidative stress, leukocytosis and cellular damage and improved recovery of RSA performance in soccer players. PMID: 32378422 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - May 7, 2020 Category: Biology Authors: Farjallah MA, Ghattassi K, Ben Mahmoud L, Graja A, Boudaya M, Elleuch H, Jammoussi K, Sahnoun Z, Souissi N, Chtourou H, Hammouda O Tags: Chronobiol Int Source Type: research

Chronotype in very low birth weight adults - a sibling study.
Kajantie E Abstract Chronotype is the temporal preference for activity and sleep during the 24 h day and is linked to mental and physical health, quality of life, and mortality. Later chronotypes, so-called "night owls", consistently display poorer health outcomes than "larks". Previous studies have suggested that preterm birth (
Source: Chronobiology International - April 30, 2020 Category: Biology Authors: Björkqvist J, Kuula J, Kuula L, Nurhonen M, Hovi P, Räikkönen K, Pesonen A, Kajantie E Tags: Chronobiol Int Source Type: research

Peripheral clock system circadian abnormalities in Cushing's disease.
In conclusion, our data suggest that Cushing's disease, which is characterized by hypercortisolism, is associated with abnormalities in the circadian pattern of clock genes. Higher expression of CRY2 at night outlines its putative role in the cortisol circadian rhythm disruption. PMID: 32354240 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - April 30, 2020 Category: Biology Authors: Soares VR, Silva Martins C, Martinez EZ, Araujo LD, Roa SLR, Silva LR, Moreira AC, De Castro M Tags: Chronobiol Int Source Type: research

Melatonin-induced phase and dose responses in a diurnal mammal, Funambulus pennantii.
Abstract Melatonin, an essential pineal hormone, acts as a marker of the circadian clock that regulates biological rhythms in animals. The effects of exogenous melatonin on the circadian system of nocturnal rodents have been extensively studied; however, there is a paucity of studies on the phase-resetting characteristics of melatonin in diurnal rodents. We studied the phase shifting effects of exogenous melatonin as a single melatonin injection (1 mg/kg) at various phases of the circadian cycle on the circadian locomotor activity rhythm in the palm squirrel, Funambulus pennantii. A phase response curve (PRC) was ...
Source: Chronobiology International - April 30, 2020 Category: Biology Authors: Soni SK, Kumar D, Singaravel M Tags: Chronobiol Int Source Type: research

A novel machine learning unsupervised algorithm for sleep/wake identification using actigraphy.
In this study, we proposed a machine learning unsupervised algorithm based on the Hidden Markov Model (HMM) for sleep/wake identification. The proposed algorithm is also an individualized approach that takes into account individual variabilities and analyzes each individual actigraphy profile separately to infer sleep and wake states. We used Actiwatch and PSG data from 43 individuals in the Multi-Ethnic Study of Atherosclerosis study to evaluate the method performance. Epoch-by-epoch comparisons and sleep variable comparisons were made between our algorithm, the unsupervised algorithm embedded in the Actiwatch software (A...
Source: Chronobiology International - April 28, 2020 Category: Biology Authors: Li X, Zhang Y, Jiang F, Zhao H Tags: Chronobiol Int Source Type: research