Systemic Anti-Oxidant Capacity Is Inversely Correlated With Systolic Blood Pressure And Pulse Pressure In Children With Obesity
oxidative stress leading to endothelial dysfunction is a candidate driver of obesity-related hypertension. We aimed to assess whether the total anti-oxidant capacity (TAC) was associated with blood pressure in children/adolescents with obesity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 18, 2019 Category: Nutrition Authors: Anita Morandi, Massimiliano Corradi, Claudia Piona, Elena Fornari, Rossella Puleo, Claudio Maffeis Source Type: research

The prognostic nutritional index might predict clinical outcomes in patients with idiopathic dilated cardiomyopathy
The prognostic nutritional index (PNI) had been associated with adverse outcomes in numerous clinical conditions. However, its influence on idiopathic dilated cardiomyopathy (DCM) was not determined. This aim of this study was to determine the predictive ability of PNI in patients with idiopathic DCM. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2019 Category: Nutrition Authors: Xiao-lan Chen, Xue-biao Wei, Jie-leng Huang, Zu-hui Ke, Ning Tan, Ji-yan Chen, Yuan-hui Liu, Dan-qing Yu Source Type: research

Improving diet quality over nine-years is associated with less weight gain in mid-age Australian women: A cohort study
Most studies measure baseline diet quality exclusively and hence the impact of longitudinal changes in dietary intake in relation to weight change is not considered. Therefore, this study aimed to examine whether change in diet quality over nine-years was associated with weight change over the same period in mid-age Australian women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 15, 2019 Category: Nutrition Authors: Haya M. Aljadani, Amanda Patterson, David Sibbritt, Rachael M. Taylor, Clare E. Collins Source Type: research

Relationship between legume consumption and metabolic syndrome: A systematic review and meta-analysis of observational studies
The prevalence of metabolic syndrome (MetS) has been increasing in recent years. Investigation of whether consumption of legumes as a part of healthy diet could reduce the odds of MetS has led to inconsistent conclusions. Here, we performed the first meta-analysis of observational studies to analyze the association between legume consumption and prevalence of MetS. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 15, 2019 Category: Nutrition Authors: Yu-Ting Jiang, Jia-Yu Zhang, Ya-Shu Liu, Qing Chang, Yu-Hong Zhao, Qi-Jun Wu Source Type: research

A higher glycemic response to oral glucose is associated with higher plasma apolipoprotein C3 independently of BMI in healthy twins
Plasma apolipoprotein C3 (ApoC3) is associated with higher plasma triglyceride and type 2 diabetes incidence. We evaluated whether body mass index (BMI) or glucose metabolism were associated with ApoC3 in healthy monozygotic (MZ) twins. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 15, 2019 Category: Nutrition Authors: Lutgarda Bozzetto, Bram J. Berntzen, Jaakko Kaprio, Aila Rissanen, Marja-Riitta Taskinen, Kirsi H. Pietil äinen. Source Type: research

Association Between Dairy Product Consumption and Hyperuricemia in an Elderly Population With Metabolic Syndrome
The prevalence of hyperuricemia has increased substantially in recent decades. It has been suggested that it is an independent risk factor for weight gain, hypertension, hypertriglyceridemia, metabolic syndrome, and cardiovascular disease. Results from epidemiological studies conducted in different study populations have suggested that high consumption of dairy products is associated with a lower risk of developing hyperuricemia. However, this association is still unclear. The aim of the present study is to explore the association between the consumption of total dairy products, their subtypes and the risk of hyperuricemia...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 11, 2019 Category: Nutrition Authors: Guillermo Mena-S ánchez, Nancy Babio, Nerea Becerra-Tomás, Miguel Ángel Martínez-González, Andrés Díaz-López, Dolores Corella, Maria Dolores Zomeño, Dora Romaguera, Jesús Vioque, Ángel M. Alonso-Gómez, Julia Wärnberg, J. Alfredo Martínez, Lu Source Type: research

The impact of probiotic yogurt consumption on lipid profiles in subjects with mild to moderate hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials
Potential beneficial effect of probiotic yogurt on the lipid profile has raised much interest. However, the results are inconsistent in this regard. The aim of the study is to determine the effects of probiotic yogurt on serum lipid profile in individuals with mild to moderate hypercholesterolemia. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 11, 2019 Category: Nutrition Authors: Behnaz Pourrajab, Somaye Fatahi, Afsaneh Dehnad, Hamed Kord Varkaneh, Farzad Shidfar Tags: Systematic Reviews and Meta-analyses Source Type: research

The effects of green coffee been extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials
This systematic review and meta-analysis aimed to assess the effects of green coffee bean extract (GCBE) supplementation on lipid profile in adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 11, 2019 Category: Nutrition Authors: Ding Feng, Baoping Ma, Ali Nazary-Vannani, Hamed Kord-Varkaneh, Somaye Fatahi, Maria Papageorgiou, Jamal Rahmani, Faezeh Poursoleiman, Israel J únior Borges do Nascimento, Hui Li, Dongyang Ham, Dongmei Wang Tags: Systematic Reviews and Meta-analyses Source Type: research

Metabolic Abnormalities, But Not Obesity Per Se, Associated with Chronic Kidney Disease in a Taiwanese Population
It is inconclusive whether obesity itself or metabolic abnormalities are linked to chronic kidney disease (CKD). The aim of this study was to examine the association between different subtypes of obesity and metabolic abnormalities with CKD in adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 8, 2019 Category: Nutrition Authors: Hung-Yu Chen, Feng-Hwa Lu, Chih-Jen Chang, Ruh-Sueh Wang, Yi-Ching Yang, Yin-Fan Chang, Jin-Shang Wu Source Type: research

Association of Daily Fish Intake with Serum Non-high-density Lipoprotein Cholesterol Levels and Healthy Lifestyle Behaviours in Apparently Healthy Males over the Age of 50 Years in Japanese: Implication for the Anti-atherosclerotic Effect of Fish Consumption
Higher fish consumption has been reported to be associated with a lower incidence of coronary artery disease (CAD). We hypothesized that higher fish intake may be associated with lower serum level of non-high-density lipoprotein cholesterol (non-HDL-C) levels, representing the entire dyslipidemia spectrum, and a healthy lifestyle. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 4, 2019 Category: Nutrition Authors: Shigemasa Tani, Rei Matsuo, Kazuhiro Imatake, Yasuyuki Suzuki, Atsuhiko Takahashi, Naoya Matsumoto Source Type: research

Irisin as a Mediator between Obesity and Vascular Inflammation in Chinese Children and Adolescents
This study aims to characterize the role of Irisin in obesity and early onset metabolic and vascular sequelae in Chinese children. Furthermore, we aim to examine whether Irisin mediate endothelial cells dysfunction and vascular inflammation which eventually leads to obesity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 3, 2019 Category: Nutrition Authors: Chunyan Yin, Wei Hu, Ming Wang, Weicheng Lv, Tian Jia, Yanfeng Xiao Source Type: research

Diabetic kidney disease: New clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on “The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function”
This joint document of the Italian Diabetes Society and the Italian Society of Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the recent epidemiological literature and provides updated recommendations on anti-hyperglycemic treatment with non-insulin agents. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 2, 2019 Category: Nutrition Authors: Giuseppe Pugliese, Giuseppe Penno, Andrea Natali, Federica Barutta, Salvatore Di Paolo, Gianpaolo Reboldi, Loreto Gesualdo, Luca De Nicola, Italian Diabetes Society and the Italian Society of Nephrology Tags: Review Source Type: research

The Role of Childhood BMI in Predicting Early Adulthood Dysglycemia: Tehran Lipid and Glucose Study
Increased adiposity is associated with insulin resistance and glycemic disturbances. We aimed to determine whether childhood overweight or obesity are independent factors in predicting adulthood dysglycemia (prediabetes or type 2 diabetes). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 1, 2019 Category: Nutrition Authors: Zahra Piri, Maryam Barzin, Maryam Mahdavi, Kamran Guity, Fereidoun Azizi, Farhad Hosseinpanah, Majid Valizadeh Source Type: research

MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4
Endothelial cell apoptosis plays an essential role in the pathogenesis of atherosclerosis. MicroRNAs and chloride intracellular channels (CLICs) have been verified to participate in the endothelial cell apoptosis process, however, the underlying molecular mechanisms are still unclear. The main aim of this study was to investigate the biological effects of microRNA-217-5p (miR-217-5p) and CLIC4 on endothelial cell apoptosis in atherosclerosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 1, 2019 Category: Nutrition Authors: Xiaotian Zhang, Zhimin Wang, Weishuai Li, Rui Huang, Dongming Zheng, Guorong Bi Source Type: research

Dietary saturated fat intake and risk of stroke: systematic review and dose-response meta-analysis of prospective cohort studies
Due to the conflicting research results, the association of saturated fatty acid (SFA) consumption and the risk of stroke remains controversial. We conducted a meta-analysis to evaluate potential dose-response relations between SFA intake and stroke. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 1, 2019 Category: Nutrition Authors: Zhou-Qing Kang, Ying Yang, Bo Xiao Tags: Systematic Reviews and Meta-analyses Source Type: research

Homocysteine levels and platelet reactivity in coronary artery disease patients treated with Ticagrelor
Recurrent atherothrombotic events have been reported in certain higher risk subsets of patients even with ticagrelor, a potent first-line antiplatelet agent for the management of patients with acute coronary syndrome (ACS). Hyperhomocysteinemia is a known determinant of platelet function abnormalities. Therefore, the aim of our study was to evaluate the impact of homocysteine (Hcy) levels on platelet reactivity in patients receiving Ticagrelor. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 30, 2019 Category: Nutrition Authors: Monica Verdoia, Roberta Rolla, Federica Negro, Francesco Tonon, Patrizia Pergolini, Matteo Nardin, Marco Marcolongo, Giuseppe De Luca, Novara Atherosclerosis Study Group (NAS) Source Type: research

Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study
Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 30, 2019 Category: Nutrition Authors: Sabine van Oort, Joline W. Beulens, Amber A.W.A. van der Heijden, Petra J.M. Elders, Coen D.A. Stehouwer, Inge A.T. van de Luitgaarden, Ilse C. Schrieks, Diederick E. Grobbee, Adriana J. van Ballegooijen Source Type: research

Grape seed procyanidin suppresses inflammation in cigarette smoke-exposed pulmonary arterial hypertension rats via PPAR γ/COX-2 pathway
Pulmonary arterial hypertension(PAH) is characterized by pulmonary vascular remodeling, which inflammation greatly accounts for. Inhibiting inflammation can relieve PAH. Grape seed procyanidin (GSP) possesses remarkable anti-inflammatory property and vascular protective function. In this experiment, we certificated anti-inflammatory function of GSP in cigarette smoke-exposed PAH rats and revealed its molecular mechanism. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 30, 2019 Category: Nutrition Authors: Jiantao Liu, Songli Hu, Bingqing Zhu, Siming Shao, Linbo Yuan Source Type: research

Dietary patterns and cardiovascular disease in Greek adults: the Hellenic National Nutrition and Health Survey (HNNHS)
Empirically-derived dietary patterns have been shown to have both positive and adverse associations with cardiovascular disease (CVD). Yet, such associations remain unclear in the Greek population. The aim of this study was to investigate the association between empirically-derived dietary patterns and the presence of CVD and CVD-related medical conditions in a nationally representative sample of Greek adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 30, 2019 Category: Nutrition Authors: D. Karageorgou, E. Magriplis, I. Bakogianni, A.V. Mitsopoulou, I. Dimakopoulos, R. Micha, G. Michas, T. Ntouroupi, S.M. Tsaniklidou, K. Argyri, M. Chourdakis, D.B. Panagiotakos, A. Zampelas, Contributors, Advisory Committee Source Type: research

Letter to the Editor about PNPLA3 gene polymorphism in Brazilian patients with type 2 diabetes: A prognostic marker beyond liver disease?
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 26, 2019 Category: Nutrition Authors: Alessandro Mantovani, Chiara Zusi Tags: Letter to the Editor Source Type: research

Lipoprotein(a) levels are associated with coronary severity but not with outcomes in Chinese patients underwent percutaneous coronary intervention
This study sought to investigate the impact of Lp(a) on coronary severity and long-term outcomes of patients who undergo percutaneous coronary intervention (PCI). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 26, 2019 Category: Nutrition Authors: Na Xu, Xiao-fang Tang, Yi Yao, Si-da Jia, Yue Liu, Xue-yan Zhao, Jue Chen, Zhan Gao, Yue-jin Yang, Run-lin Gao, Bo Xu, Jin-qing Yuan Source Type: research

Cyclic Glycine-Proline Normalizes Systolic Blood Pressure in High-fat Diet-Induced Obese Male Rats
Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glycine-proline (cGP) is a natural nutrient and regulates the amount of active IGF-1 in plasma. Plasma cGP decreases in hypertensive women whereas increases in obese women, suggesting its involvement in cardio-metabolic function. We therefore examined the effects of cGP on metabolic profiles and blood pressure in high-fat diet (HFD)-induced obese male rats. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 25, 2019 Category: Nutrition Authors: Fengxia Li, Karen Liu, Clint Gray, Paul Harris, Clare M. Reynolds, Mark H. Vickers, Jian Guan Source Type: research

Worldwide burden of LDL cholesterol: implications in cardiovascular disease
an increased value of low-density lipoprotein cholesterol (LDL-C) is now universally considered a major cardiovascular disease (CVD) risk factor. LDL-C is included in the vast majority of worldwide cardiovascular risk prediction algorithms, as well as in the guidelines for cardiovascular risk prevention. We aimed to provide an overview of the worldwide adverse healthcare impact of low-density lipoprotein cholesterol (LDL-C). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 24, 2019 Category: Nutrition Authors: Camilla Mattiuzzi, Fabian Sanchis-Gomar, Giuseppe Lippi Tags: Short Communication Source Type: research

Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity
Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 23, 2019 Category: Nutrition Authors: Jose Carlos de Lima-Junior, Vitor W.M. Virginio, Filipe A. Moura, Adriana Bertolami, Marcelo Bertolami, Otavio R. Coelho-Filho, Ilaria Zanotti, Wilson Nadruz, Eliana Cotta de Faria, Luiz Sergio F. de Carvalho, Andrei C. Sposito Source Type: research

Reply to Drs Mantovani and Zusi
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 21, 2019 Category: Nutrition Authors: Cristiane A. Villela-Nogueira, Nathalie C. Leite, Carolina M. Machado, Claudia R. Cardoso, Gil F. Salles Tags: Letter to the Editor Source Type: research

Value of Triglyceride-glucose Index for the Estimation of Ischemic Stroke Risk: Insights from a general Population
Recent studies have recognized triglyceride-glucose index (TyG) as a practical surrogate of insulin resistance. Previous studies have demonstrated that insulin resistance contributes to ischemic stroke via multiple mechanisms. Our study aimed to investigate the association between TyG and prevalent ischemic stroke, exploring the value of TyG to optimize the risk stratification of ischemic stroke. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 21, 2019 Category: Nutrition Authors: Wenrui Shi, Liying Xing, Li Jing, Yuanmeng Tian, Han Yan, Qun Sun, Dong Dai, Lei Shi, Shuang Liu Source Type: research

Chronic metformin reduces systemic and local inflammatory proteins and improves hypertension-related cardiac autonomic dysfunction
Metformin has been known to promote cardiovascular benefits in humans and animal models, even in non-diabetic subjects. However, its chronic effects on hypertension-related autonomic dysfunction remain poorly understood. Therefore, we evaluate the cardiac autonomic effects of chronic metformin in hypertensive rats. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 18, 2019 Category: Nutrition Authors: Phablo Wendell C. Oliveira, Glauciene J. de Sousa, Antonio Marcos Birocale, S ônia A. Gouvêa, Suely G. de Figueiredo, Gláucia R. de Abreu, Nazaré S. Bissoli Source Type: research

Statins therapy and colorectal cancer risk
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 18, 2019 Category: Nutrition Authors: Shih-Wei Lai, Yu-Hung Kuo, Chia-Wei Fang, Kuan-Fu Liao Tags: Letter to the Editor Source Type: research

Platelet function and activation markers in primary hypercholesterolemia treated with PCSK9 monoclonal antibody: a 12-month follow-up
In the association between hypercholesterolemia (HC) and thrombotic risk platelet hyper-reactivity plays an important role. The inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) to reduce plasma LDL ‐cholesterol merges as effective therapeutic strategy to prevent cardiovascular (CV) events. Aim of this study was to verify whether a treatment up to 12 months with the monoclonal antibodies (mAbs) anti-PCSK9 influences platelet function in primary HC. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 17, 2019 Category: Nutrition Authors: Cristina Barale, Katia Bonomo, Chiara Frascaroli, Alessandro Morotti, Angelo Guerrasio, Franco Cavalot, Isabella Russo Source Type: research

Exploring the causal pathway from omega-6 levels to coronary heart disease: A network Mendelian randomization study
Evidence on the effect of omega-6 fats on coronary heart disease (CHD) risk remains inconclusive. We applied a network MR framework to determine the causal effects between omega-6 levels and CHD and the potential cholesterol metabolic risk factors (Total cholesterol, TC; Low-density lipoprotein cholesterol, LDL-C; High-density lipoprotein cholesterol, HDL-C; Triglycerides, TG) which might act as mediators in the link between omega-6 levels and CHD by integrating summary-level genome wide association study (GWAS) data. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 16, 2019 Category: Nutrition Authors: Li-zhen Liao, Wei-dong Li, Ying Liu, Jia-ping Li, Xiao-dong Zhuang, Xin-xue Liao Source Type: research

Influence of muscle mass on the serum uric acid levels in children and adolescents
Uric acid (UA) is an end-product of purine catabolism and its increase in blood is a risk factor for several diseases. UA levels in men are usually higher than in women. This difference is partially due to sex hormones. We sought to investigate the onset of sexual difference in UA levels during pubertal development and the determinants of UA levels in children and adolescents. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 13, 2019 Category: Nutrition Authors: Rafael O. Alvim, Jordana H. Siqueira, Divanei Zaniqueli, Deyse M. Dutra, Polyana R. Oliosa, Jos é Geraldo Mill Source Type: research

Ameliorative Effects of Hempseed (Cannabis Sativa) Against Hypercholesterolemia Associated Cardiovascular Changes
Hypercholesterolemia (HC) is a major risk factor for cardiovascular (CV) diseases, that are the major cause of mortality worldwide. Free radicals mediated oxidative stress is a critical player in HC-associated pathophysiological insults including atherosclerosis. Unwanted side effects associated with statins, COX-2 inhibitors, and other synthetic drugs limit their use. Thus, modulation of oxidative stress during HC using green pharmaceuticals seems an appropriate approach against deleterious CV consequences without noticeable side-effect. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 13, 2019 Category: Nutrition Authors: Naveen Kaushal, Shallu Dhadwal, Parminder Kaur Source Type: research

Preclinical vascular alterations in obese adolescents detected by Laser-Doppler Flowmetry technique
This study evaluated whether alterations in skin microcirculation were already present in obese adolescents in a pre-clinical phase of cardiovascular disease. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 13, 2019 Category: Nutrition Authors: E. Fusco, M. Pesce, V. Bianchi, E. Randazzo, S. Del Ry, D. Peroni, M. Rossi, G. Federico Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 10, 2019 Category: Nutrition Source Type: research

Phenotypes and concentration of PON1 in cardiovascular disease: the role of nutrient intake
Paraoxonase 1 (PON1) is considered to play a crucial role as an anti-atherosclerotic factor. The PON1 activity is affected by genetic polymorphisms, environmental factors, age, sex, lifestyle, pharmaceutical drugs, and dietary factors. The aim of this study was to evaluate the association between macro- and micronutrients as well as PON1 concentration and activities in patients with cardiovascular diseases (CVD), cardiovascular risk factors but no CVD (CRF), and in healthy controls (control group). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 10, 2019 Category: Nutrition Authors: N. Ponce-Ruiz, F.E. Murillo-Gonz ález, A.E. Rojas-García, Y.Y. Bernal-Hernández, Mike Mackness, J. Ponce-Gallegos, B.S. Barrón-Vivanco, I. Hernández-Ochoa, C.A. González-Arias, L. Ortega-Cervantes, G. Cardoso-Saldaña, I.M. Medina-Díaz Source Type: research

Serum 25-hydroxyvitamin-D and nonalcoholic fatty liver disease: Does race/ethnicity matter? Findings from the MESA Cohort
Low serum 25-hydroxyvitamin D (25(OH)D) is associated with higher nonalcoholic fatty liver disease (NAFLD) risk in studies of mainly white participants. Significant racial/ethnic differences exist in serum 25(OH)D and NAFLD prevalence questioning extending this association to other racial/ethnic groups. We tested whether the association between serum 25(OH)D and NAFLD vary by race/ethnicity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 10, 2019 Category: Nutrition Authors: Samar.R. El Khoudary, Saad Samargandy, Irfan Zeb, Temitope Foster, Ian H. de Boer, Dong Li, Matthew J. Budoff Source Type: research

Diabetes Diagnosis from Administrative Claims and Estimation of the True Prevalence of Diabetes among 4.2 Million Individuals of the Veneto Region (North East Italy)
Diabetes can often remain undiagnosed or unregistered in administrative databases long after its onset, even when laboratory test results meet diagnostic criteria. In the present work, we analyse healthcare data of the Veneto Region, North East Italy, with the aims of: (i) developing an algorithm for the identification of diabetes from administrative claims (4,236,007 citizens), (ii) assessing its reliability by comparing its performance with the gold standard clinical diagnosis from a clinical database (7,525 patients), (iii) combining the algorithm and the laboratory data of the regional Health Information Exchange (rHIE...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Claudio Saccavini, Angelo Avogaro, Gian Paolo Fadini Source Type: research

Osteoprotegerin in diabetic osteopathy
The aim of this study is to evaluate the relationship between OPG and the degree of glycaemic control in a population of elderly subjects. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Alessia Valentini, Maria Assunta Cianfarani, Massimo Federici, Umberto Tarantino, Aldo Bertoli Tags: Review Source Type: research

Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice
Cardiovascular diseases are the main cause of mortality in obesity. Despite advanced understanding, the mechanisms that regulate cardiac progenitor cells (CPC) survival in pathological conditions are not clear. Low IGF-1 plasma levels are correlated to obesity, cardiomyopathy and CPC death, so this work aimed to investigate IGF-1 therapeutic potential on cardiomyopathy and its relationship with the survival, proliferation and differentiation of CPC in Western diet-induced obesity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Daniela Andrade, Genilza Oliveira, Luciana Menezes, Ana L úcia Nascimento, Simone Carvalho, Ana Carolina Stumbo, Alessandra Thole, Érica Garcia-Souza, Anibal Moura, Laís Carvalho, Erika Cortez Source Type: research

Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on normal or low phosphorus diet?
Experimental rodent models suggest that hypoxia with subsequent increase in erythropoietin stimulates the expression of the phosphaturic hormone fibroblast growth factor 23 (FGF23). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: I.E. Emrich, J. Dederer, A. Kircher, V. Klemis, C.S. Lennartz, K. Untersteller, S. Wagenpfeil, D. Fliser, M. Wolf, G.H. Heine Source Type: research

Carbohydrate intake and risk of metabolic syndrome: a dose-response meta-analysis from observational studies
Epidemiological association studies have shown inconsistent findings between carbohydrate intake and risk of metabolic syndrome (MetS). Therefore, we aim to conduct the first dose-response meta-analysis to investigate this effect. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Ya-Shu Liu, Qi-Jun Wu, Yang Xia, Jia-Yu Zhang, Yu-Ting Jiang, Qing Chang, Yu-Hong Zhao Tags: Systematic Reviews and Meta-analyses Source Type: research

The Association of Dietary Patterns and Carotid Intima-Media Thickness: A Synthesis of Current Evidence
This study systematically explores the association of a posteriori and a priori DPs and CIMT. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 3, 2019 Category: Nutrition Authors: S. Bhat, G. Mocciaro, S. Ray Tags: Systematic Reviews and Meta-analyses Source Type: research

Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
To evaluate the biomarkers related to cardiovascular risk in pre-pubertal preterm children with a birth weight of less than 1,500g and relate them to current nutritional status, insulin resistance, and inflammation. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 31, 2019 Category: Nutrition Authors: D.O. Schoeps, S. Holzer, F.I.M.D. Suano-Souza, S. Hix, F.L.A. Fonseca, R.O.S. Sarni Source Type: research

Circulating glutamate level as a potential biomarker for abdominal obesity and metabolic risk
Circulating level of glutamate, a by-product of the catabolism of branched-chain amino acids, has been positively correlated with visceral adipose tissue accumulation and waist circumference (WC). The aim of the present study was to assess the potential of using glutamate level to identify individuals with abdominal obesity and a high cardiometabolic risk. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 31, 2019 Category: Nutrition Authors: I. Maltais-Payette, B. Allam-Ndoul, L. P érusse, M.-C. Vohl, A. Tchernof Source Type: research

Physical Activity Intervention Improved The Number And Functionality Of Endothelial Progenitor Cells In Low Birth Weight Children
The purpose of this study was to investigate whether an intervention with physical activity (PA) would promote positive effects on the angiogenic factors, mobilization, and functionality of circulating endothelial progenitor cells (EPCs) in children with low birth weight (LBW). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 30, 2019 Category: Nutrition Authors: Livia V. Souza, Franciele De Meneck, Tiago Fernandes, Edilamar M. Oliveira, Maria do Carmo Franco Source Type: research

Postnatal delayed growth impacts cognition but rescues programmed impaired pulmonary vascular development in an IUGR rat model
Intrauterine growth restriction (IUGR) is a state of slower fetal growth usually followed by a catch-up growth. Postnatal catch-up growth in IUGR models increases the incidence of pulmonary arterial hypertension in adulthood. Here, we hypothesize that the adverse pulmonary vascular consequences of IUGR may be improved by slowing down postnatal growth velocity. Meanwhile, cognitive function was also studied. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 30, 2019 Category: Nutrition Authors: LingLing Yan, Yu Wang, ZiMing Zhang, ShanShan Xu, Rahim Ullah, XiaoFei Luo, XueFeng Xu, XiaoLu Ma, Zheng Chen, LiYan Zhang, Ying Lv, LiZhong Du Source Type: research

Factors associated with longitudinal changes in serum concentrations of Mac-2 binding protein: a prospective 3-year observational study
Mac-2 binding protein (M2BP) plays an important role in cell adhesion. In a recent cross-sectional study we reported that serum M2BP concentrations may reflect silent atherosclerosis. The aim of the present prospective follow-up study was to investigate possible relationships between changes in concentrations of M2BP and other factors over a>3-year period. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 24, 2019 Category: Nutrition Authors: Tomonori Sugiura, Yasuaki Dohi, Hiroyuki Takase, Sumiyo Yamashita, Yuji Tsuzuki, Shintaro Ogawa, Yasuhito Tanaka, Nobuyuki Ohte Source Type: research

Associations of a Metabolic Syndrome Severity Score with Coronary Heart Disease and Diabetes in Fasting vs. Non-fasting Individuals
Many traditional assessments of risk for coronary heart disease (CHD) and diabetes require laboratory studies performed after an 8-hour fast. We assessed whether metabolic-syndrome (MetS) severity would remain linked to future CHD and diabetes even when assessed from non-fasting samples. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 24, 2019 Category: Nutrition Authors: Mark D. DeBoer, Stephanie L. Filipp, Matthew J. Gurka Source Type: research

Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors
The aim of this study was to investigate possible associations among markers of mineralization, plaque instability and the main risk factors of atherosclerosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 23, 2019 Category: Nutrition Authors: Manuel Scimeca, Lucia Anemona, Annarita Granaglia, Rita Bonfiglio, Nicoletta Urbano, Nicola Toschi, Giuseppe Santeusanio, Stefania Schiaroli, Silvestro Mauriello, Virginia Tancredi, Orazio Schillaci, Elena Bonanno, Alessandro Mauriello Source Type: research

Systemic lupus erythematosus is associated with poor outcome after acute myocardial infarction
Systemic lupus erythematosus (SLE) is associated with a higher risk of cardiovascular disease. However, whether or not SLE is associated with poor outcomes after acute myocardial infarction (AMI) is not clear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 20, 2019 Category: Nutrition Authors: Shin-Rong Ke, Cheng-Wei Liu, Yen-Wen Wu, K. Robert Lai, Chiung-Yi Wu, Jeng-Wei Lin, Chien-Lung Chan, Ren-Hao Pan Source Type: research