Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 15, 2020 Category: Nutrition Source Type: research

Pre-existing type 2 diabetes is associated with increased all-cause death independently of echocardiographic predictors of poor prognosis only in ischemic heart disease
It is unknown whether the prognostic role of diabetes (T2DM) in outpatients with chronic heart failure (CHF) is independent of the most important echocardiographic markers of poor prognosis. The aims of this analysis were to evaluate whether T2DM modifies the risk of mortality in CHF patients stratified by etiology of disease or by right-ventricular to pulmonary arterial coupling at echocardiography and to evaluate how T2DM interacts with the prognostic role of cardiac plasma biomarkers. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 15, 2020 Category: Nutrition Authors: Stefano Ghio, Catherine Klersy, Erberto Carluccio, Angela Beatrice Scardovi, Laura Scelsi, Calogero Falletta, Andrea Rossi, Pompilio Faggiano, Egidio Traversi, Olga Vriz, Marco Guazzi, Frank Lloyd Dini, Giovanni Targher, Pier Luigi Temporelli Tags: Short Communication Source Type: research

The role of insulin resistance in the relation of visceral, abdominal subcutaneous and total body fat to cardiovascular function
This study aimed to investigate the role of insulin resistance in the relations of visceral (VAT), abdominal subcutaneous (aSAT) adipose tissue and total body fat (TBF) to cardiovascular remodeling. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 15, 2020 Category: Nutrition Authors: Elisabeth H.M. Paiman, Ren ée de Mutsert, Ralph L. Widya, Frits R. Rosendaal, J. Wouter Jukema, Hildo J. Lamb Source Type: research

Change in abdominal, but not femoral subcutaneous fat CT-radiodensity is associated with improved metabolic profile after bariatric surgery
Computed tomography (CT)-derived adipose tissue radiodensity represents a potential noninvasive surrogate marker for lipid deposition and obesity-related metabolic disease risk. We studied the effects of bariatric surgery CT-derived adipose radiodensities in abdominal and femoral areas and their relationships to circulating metabolites in morbidly obese patients (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 14, 2020 Category: Nutrition Authors: Prince Dadson, Eleni Rebelos, Henri Honka, Luis Eduardo Ju árez-Orozco, Kari K. Kalliokoski, Patricia Iozzo, Jarmo Teuho, Paulina Salminen, Jussi Pihlajamäki, Jarna C. Hannukainen, Pirjo Nuutila Source Type: research

Continuous glucose monitoring in subjects undergoing bariatric surgery: diurnal and nocturnal glycemic patterns
Although the use of Continuous Glucose Monitoring (CGM) is rapidly extending, little evidence is currently available on daily glycemic excursions after different bariatric procedures. We assessed glycemic patterns after sleeve gastrectomy (SG) and roux-en-Y gastric bypass (RYGB) using CGM. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 11, 2020 Category: Nutrition Authors: Roberta Lupoli, Erminia Lembo, Paola Ciciola, Luigi Schiavo, Vincenzo Pilone, Brunella Capaldo Source Type: research

Performance of the Steno type 1 risk engine for cardiovascular disease prediction in Italian patients with type 1 diabetes
Premature cardiovascular disease cause excess mortality in type 1 diabetes (T1D). The Steno T1D Risk Engine was developed and validated in northern European countries but its validity in other populations is unknown. We evaluated the performance of the Steno T1D Risk Engine in Italian patients with T1D. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 10, 2020 Category: Nutrition Authors: Federico Boscari, Mario Luca Morieri, Anna Maria Letizia Amato, Valeria Vallone, Ambra Uliana, Anna Baritussio, Nicola Vitturi, Elisa Cipponeri, Francesco Cavallin, Angelo Avogaro, Gian Paolo Fadini, Daniela Bruttomesso Source Type: research

Immunoglobulins G Modulate Endothelial Function and affect Insulin Sensitivity in Humans
Data from animals suggest that immunoglobulins G (IgG) play a mechanistic role in atherosclerosis and diabetes through endothelial dysfunction and insulin resistance. Patients with common variable immunodeficiency (CVID), who have low circulating levels of IgG and are treated with intravenous polyclonal IgG (IVIgG), may provide an ideal model to clarify whether circulating IgG modulate endothelial function and affect insulin sensitivity in humans. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 10, 2020 Category: Nutrition Authors: Raffaele Napoli, Antonio Ruvolo, Paola Triggianese, Nella Prevete, Gabriele G. Schiattarella, Cecilia Nigro, Claudia Miele, Fabio Magliulo, Simona Grassi, Antonio Pecoraro, Antonio Cittadini, Giovanni Esposito, Amato de Paulis, Giuseppe Spadaro Source Type: research

Remnant Cholesterol as a risk factor for cardiovascular, Cancer or other causes mortality: a competing risks analysis
Cardiovascular diseases (CVDis) are leading causes of morbidity and mortality. Even after the introduction of pharmacological therapy to lower Cholesterol, there is still a residual risk that may be ascribed to Remnant Cholesterol (RC). We aimed, by analyzing two prospective cohort studies, to estimate the effect of RC on risk and hazard of Cardiovascular Deaths (CVDs), while accounting for competing risks such as Cancer (CDs) and Other-Causes Deaths (OCDs). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 10, 2020 Category: Nutrition Authors: Caterina Bonfiglio, Carla Maria Leone, Liciana Vaz de Arruda Silveira, Rocco Guerra, Giovanni Misciagna, Maria Gabriella Caruso, Irene Bruno, Claudia Buongiorno, Angelo Campanella, Vito Maria Bernardo Guerra, Maria Notarnicola, Valentina Deflorio, Isabell Source Type: research

Pre-existing diabetes is worse for SARS-CoV-2 infection; an endothelial perspective
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 8, 2020 Category: Nutrition Authors: Lucia La Sala, Livio Luzi, Antonio E. Pontiroli Tags: Letter to the Editor Source Type: research

Using 2nd Generation Basal Insulins in Type 2 Diabetes: Costs and Savings in a Comparative Economic Analysis in Italy, based on the BRIGHT Study
To evaluate the economic impact of using 2nd generation basal insulin analogs, Glargine 300 Units/ml (Gla-300) vs Degludec 100 Units/ml (IDeg-100), in patients with type 2 diabetes (T2D). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 7, 2020 Category: Nutrition Authors: Raffaele Napoli, Francesca Fanelli, Luca Gazzi, Monica Larosa, Rossella Bitonti, Gianluca Furneri Source Type: research

The association of PAI-1 with 24-hour blood pressure in young healthy adults is influenced by smoking and alcohol use: the African-PREDICT study
The association between plasminogen activator inhibitor-1 (PAI-1) and blood pressure is well established, but it is debatable whether raised PAI-1 levels precede or result from raised blood pressure. Furthermore, it is unclear whether this association already exists in the absence of overt hypertension and to what degree it is influenced by health behaviours. Our aim was to investigate the association of 24-hour blood pressure with PAI-1 activity (PAI-1act) in a young, healthy cohort, and to assess the influence of alcohol consumption and smoking on these associations. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 6, 2020 Category: Nutrition Authors: Adriaan JACOBS, Marlien PIETERS, Aletta E. SCHUTTE Source Type: research

Association between Daily Egg Intake and Lipid Profiles in Adults from the Henan Rural Cohort Study
The association between daily egg intake and dyslipidemia remains a contentious issue. Therefore, our study was aimed to explore the relation of daily egg intake to lipid profile; and whether the association was mediated by body mass index (BMI). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 6, 2020 Category: Nutrition Authors: Chang Liu, Yuan Xue, Yan Wang, Yujing Zhang, Dongdong Zhang, Dou Qiao, Bingya Wang, Fang Shen, Zhenxing Mao, Songcheng Yu, Chongjian Wang, Wenjie Li, Xing Li Source Type: research

Associations between dietary patterns and gene expression pattern in peripheral blood mononuclear cells: a cross-sectional study
Diet may alter gene expression in immune cells involved in atherosclerotic cardiovascular disease susceptibility. However, we still lack a robust understanding of the association between diet and immune cell-related gene expression in humans. Therefore, we examined associations between dietary patterns (DPs) and gene expression profiles in peripheral blood mononuclear cells (PBMCs) in a population of healthy, Norwegian adults (n = 130 women and 105 men). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 2, 2020 Category: Nutrition Authors: Jacob J. Christensen, Stine M. Ulven, Magne Thoresen, Kenneth Westerman, Kirsten B. Holven, Lene F. Andersen Source Type: research

Self-management education may improve blood pressure in people with type 2 diabetes. A randomized controlled clinical trial
In this study, we aimed at investigating the effects of group based self-management education on clinical and psychological variables in type 2 diabetes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 1, 2020 Category: Nutrition Authors: Marina Trento, Paolo Fornengo, Cristina Amione, Martina Salassa, Federica Barutta, Gabriella Gruden, Aurora Mazzeo, Stefano Merlo, Mario Chiesa, Franco Cavallo, Lorena Charrier, Massimo Porta Source Type: research

Effect of cognitive behavioral therapy on sleep disturbances and quality of life among adults with type 2 diabetes mellitus: A randomized controlled trial
Cognitive behavioral therapy (CBT) is recommended as the first-line nonpharmacotherapy for sleep complaints.However, there are no studies that tested CBT for improving sleep quality and increasing QOL in patients with type 2 diabetes mellitus(T2DM). To test effect of CBT for sleep disturbances and quality of life in type 2 diabetes mellitus. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 1, 2020 Category: Nutrition Authors: Xiaowei Zuo, Zongmei Dong, Peng Zhang, Pan Zhang, Guiqiu Chang, Quanyong Xiang, Xianghua Zhu, Jinyi Zhou, Cheng Qiao, Yongjie Yang, Yu Qin, Peian Lou Source Type: research

The other side of the medallion in heart failure: Reverse Metabolic Syndrome
Lower levels of cardiovascular risk factors are associated with an increase in mortality in H.F. To explain this paradox, the term reverse metabolic syndrome (RMetS) has recently been proposed. We suggest defining these patients with lower levels of three risk factors can be combined under the heading "RMetS." We aimed to investigate the effect of MetS and RMetS on hemodynamic parameters and prognosis in patients with H.F. and reduced ejection fraction (HFrEF) (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 1, 2020 Category: Nutrition Authors: Elif Hande Ozcan Cetin, Mehmet Serkan Cetin, Mustafa Bilal Özbay, Nezaket Merve Yaman, Hasan Can Könte, Firdevs Aysenur Ekizler, Bahar Tekin Tak, Meryem Kara, Ahmet Temizhan, Fırat Özcan, Özcan Özeke, Serkan Çay, Serkan Topaloglu, Dursun Aras Source Type: research

Evolving trend in the management of heterozygous familial hypercholesterolemia in Italy: a retrospective, single center, observational study
The effective reduction of LDL-C in patients with heterozygous familial hypercholesterolemia (HeFH) is crucial to reduce their increased cardiovascular risk. Diagnostic and therapeutic (PCSK9 inhibitors) tools to manage HeFH improved in recent years. However, the impact of these progresses in ameliorating the contemporary real-world care of these patients remains to be determined. Aim of this study was to assess the evolution of treatments and LDL-C control in a cohort of HeFH patients in Italy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 1, 2020 Category: Nutrition Authors: Laura D ’Erasmo, Daniela Commodari, Alessia Di Costanzo, Ilenia Minicocci, Luca Polito, Fabrizio Ceci, Anna Montali, Marianna Maranghi, Marcello Arca Source Type: research

Association between weight status, metabolic syndrome and chronic kidney disease among middle-aged and elderly Chinese
This study sought to examine the independent and joint relations of weight and metabolic syndrome (MetS) with incident chronic kidney disease (CKD) among Chinese elderly people. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 30, 2020 Category: Nutrition Authors: Yi Wang, Bin Sun, Li-Ting Sheng, Xiong-Fei Pan, Yanfeng Zhou, Jiang Zhu, Xiulou Li, Kun Yang, Kunquan Guo, Xiaomin Zhang, Meian He, Handong Yang, Tangchun Wu, An Pan Source Type: research

Metabolic Syndrome, High-sensitivity C-reactive Protein Levels and the Risk of New-Onset Atrial Fibrillation: Results from the Kailuan Study
Some studies have reported that metabolic syndrome (MS) and a high inflammatory state are risk factors for atrial fibrillation (AF). However, the combined effect of MS and a high inflammatory state on AF is still unknown. We aimed to investigate the association of MS and high-sensitivity C-reactive protein (hs-CRP) levels with the risk of AF in a large community-based population. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 30, 2020 Category: Nutrition Authors: Zhao Wang, Binhao Wang, Xintao Li, Shengmin Zhang, Shouling Wu, Yunlong Xia Source Type: research

Branched chain amino acids, history of gestational diabetes, and breastfeeding: The Bogalusa Heart Study
To examine the associations between history of gestational diabetes mellitus (GDM) and breastfeeding with branched-chain amino acids (BCAA) and their metabolites in later life. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 29, 2020 Category: Nutrition Authors: Emily Harville, Lydia Bazzano, Lu Qi, Jiang He, Kirsten Dorans, Wei Perng, Tanika Kelly Source Type: research

Aspirin in a Diabetic Retinopathy Setting: insights from NO BLIND Study
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes. Diabetic macroangiopathies, particularly cardiovascular (CV) diseases, seems closely related to diabetes microvascular complications. Aspirin represents the most prescribed compound in CV prevention. Aspirin impact on DR is still object of debate. As aspirin is already recommended among diabetics at high CV risk, aim of this study was to assess a potential relationship between DR and aspirin therapy, in a type 2 diabetes cohort of patients screened through telemedicine. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 29, 2020 Category: Nutrition Authors: Pia Clara Pafundi, Raffaele Galiero, Alfredo Caturano, Carlo Acierno, Chiara de Sio, Erica Vetrano, Riccardo Nevola, Aldo Gelso, Valeria Bono, Ciro Costagliola, Raffaele Marfella, Celestino Sardu, Luca Rinaldi, Teresa Salvatore, Luigi Elio Adinolfi, Ferdi Source Type: research

A Single One-Minute, Comfortable Paced, Stair-Climbing Bout Reduces Postprandial Glucose Following a Mixed Meal
Postprandial blood glucose (PBG) is an independent predictor of disease and mortality risk. To date, the shortest, single, moderate intensity exercise intervention to reduce PBG is a 1-min bout of stair stepping during an oral glucose tolerance test. Whether this effect translates to real meal consumption is unknown. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 28, 2020 Category: Nutrition Authors: Jeff Moore, Hannah Salmons, Cameron Vinoskey, Jochen Kressler Source Type: research

Clinical values of creatine kinase and its isoenzymes in children and adolescents with vasovagal syncope
Vasovagal syncope (VVS) in children and adolescents is a common disorder. There may be an internal relationship between creatine kinase (CK) and its isoenzymes (CKMB) and syncope. The aim of this study was to evaluate the changes of CK and CKMB in children and adolescents with VVS. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 28, 2020 Category: Nutrition Authors: Juan Zhang, Haoneng Tang, Yuwen Wang, Hong Cai, Runmei Zou, Shuo Wang, Cheng Wang Source Type: research

Association between Triglyceride and Glycose (TyG) index and subclinical myocardial injury
Triglyceride and glycose (TyG) index has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We hypothesized that elevated TyG index is associated with increased risk of subclinical myocardial injury (SC-MI). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 28, 2020 Category: Nutrition Authors: Yihai Liu, Mingyue Wu, Jiamin Xu, Dujuan Sha, Biao Xu, Lina Kang Source Type: research

Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease
Increased intestinal permeability plays a key role in the pathogenesis of fat deposition in the liver. The aim of our study was to assess whether a single nucleotide polymorphism of protein tyrosine phosphatase non-receptor type 2 (PTPN2) (rs2542151 T →G), involved in intestinal permeability, may be associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 27, 2020 Category: Nutrition Authors: Luca Miele, Valentina Giorgio, Antonio Liguori, Salvatore Petta, Roberta Pastorino, Dario Arzani, Maria A. Alberelli, Consuelo Cefalo, Giuseppe Marrone, Marco Biolato, Gianludovico Rapaccini, Stefania Boccia, Antonio Gasbarrini, Antonio Crax ì, Antonio G Source Type: research

Association of Plasma Trimethylamine N-Oxide Level with Healed Culprit Plaques Examined by Optical Coherence Tomography in Patients with ST-Segment Elevation Myocardial Infarction
Healed plaque is a hallmark of previous regional plaque rupture or erosion. We hypothesized that the plasma level of trimethylamine N-oxide (TMAO) is related to healed culprit plaque in ST-segment Elevation Myocardial Infarction (STEMI) patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 26, 2020 Category: Nutrition Authors: Jiannan Li, Zhaoxue Sheng, Yu Tan, Peng Zhou, Chen Liu, Hanjun Zhao, Li Song, Jinying Zhou, Runzhen Chen, Yi Chen, Hongbing Yan Source Type: research

Do the 2017 blood pressure cut-offs improve 10-year cardiovascular disease mortality risk prediction?
High blood pressure (BP) is a significant predictor for cardiovascular disease (CVD) mortality. The 2017 American College of Cardiology/American Heart Association guideline reclassified the BP categories; however, its impact on CVD mortality prediction is still unclear. Our study aimed to examine whether the application of new BP cut-offs could improve 10-year CVD mortality prediction among US adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 26, 2020 Category: Nutrition Authors: Yang Peng, Zhiqiang Wang Source Type: research

The Effects of Aspirin and N-3 Fatty Acids on Telomerase Activity in Adults with Diabetes Mellitus
Type 2 Diabetes mellitus is associated with aging and shortened telomere length. Telomerase replaces lost telomeric repeats at the ends of chromosomes and is necessary for the replicative immortality of cells. Aspirin and the n3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are commonly used therapies in people with type 2 diabetes for reducing cardiovascular disease events, though their relation to telomerase activity is not well studied. We explored the effects of aspirin, EPA+DHA, and the combined effects of aspirin and EPA+DHA treatment on telomerase activity in 30 adults with diabetes mellitus...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 25, 2020 Category: Nutrition Authors: Ashley Holub, Shaker Mousa, Amir Abdolahi, Kavitha Godugu, Xin M. Tu, J Thomas Brenna, Robert C. Block Tags: Short Communication Source Type: research

Energy drink intake and metabolic syndrome: a prospective investigation in young adults
There are concerns that energy drinks (EDs) are contributing to upward trends in overweight, obesity, and cardiometabolic conditions in young people. We investigated cross-sectional and prospective associations between frequency of ED-intake in young-adults and (i) body mass index (BMI) and (ii) Metabolic Syndrome (MetS) and its components. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 22, 2020 Category: Nutrition Authors: Gina Trapp, Miriam Hurworth, Peter Jacoby, Hayley Christian, Gina Ambrosini, Wendy Oddy, Leon Straker, Trevor Mori, Lawrence Beilin, Karina Allen Tags: Short Communication Source Type: research

Left ventricular mass and urinary metabolomics in young black and white adults: The African-PREDICT study
Increased left ventricular mass is an independent predictor for cardiovascular events, and shown to be higher in black than white populations. To gain a better understanding of early factors contributing to increased left ventricular mass in young black adults, we investigated metabolomic profiles, identified and compared metabolites that associated with left ventricular mass index in healthy black and white adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 22, 2020 Category: Nutrition Authors: Dalene De beer, Catharina Mc Mels, Aletta E. Schutte, Roan Louw, Christian Delles, Ruan Kruger Source Type: research

Developmental origins of cardiometabolic health outcomes in twins: A systematic review and meta-analysis
Studies of twins can reduce confounding and provide additional evidence about the causes of disease, due to within-pair matching for measured and unmeasured factors. Although findings from twin studies are typically applicable to the general population, few studies have taken full advantage of the twin design to explore the developmental origins of cardiometabolic health outcomes. We aimed to systematically review the evidence from twin studies and generate pooled estimates for the effects of early-life risk factors on later-life cardiometabolic health. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 22, 2020 Category: Nutrition Authors: Deborah N. Ashtree, Amelia J. McGuinness, Michelle Plummer, Cong Sun, Jeffrey M. Craig, Katrina J. Scurrah Tags: Systematic Reviews and Meta-analyses Source Type: research

Association of General and Abdominal Obesity and their Changes with Stroke in Chinese Adults: Results from an 11.8-year Follow-up Study
This study was performed to investigate the association of general and abdominal obesity and their changes with stroke in Chinese adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 22, 2020 Category: Nutrition Authors: Sitong Liu, Zihui Gao, Yue Dai, Rongrong Guo, Yali Wang, Zhaoqing Sun, Liying Xing, Xingang Zhang, Yingxian Sun, Liqiang Zheng Source Type: research

Time spent in target range assessed by self-monitoring blood glucose associates with glycated hemoglobin in insulin treated patients with diabetes
This study evaluates the association between HbA1c and TIR, evaluated through DMS, over 2 months, and 2 weeks. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 20, 2020 Category: Nutrition Authors: Antonio Cutruzzol à, Concetta Irace, Martina Parise, Raffaella Fiorentino, Pier Francesco Pio Tripodi, Serena Ungaro, Valerie Babinsky, Agostino Gnasso Source Type: research

Uric acid fluctuation had no effect on renal function among gout patients
To investigate the effects of serum uric acid (SUA) level and its fluctuation on renal dysfunction in gout patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 20, 2020 Category: Nutrition Authors: Jianyong Shen, Jianing Zhu, Shuting Si, Yun Fu, Minjia Mo, Xing Xin, Bule Shao, Yu Shen, Shuojia Wang, Huaxiang Wu, Yunxian Yu Source Type: research

Diabetic Ketoacidosis: A Consensus Statement of the Associazione Medici Diabetologi (AMD), Societ à Italiana di Diabetologia (SID), Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP)
Diabetic ketoacidosis (DKA) is a serious medical emergency once considered typical of type 1 diabetes (T1DM), but now reported in type 2 and GDM patients too. Though, DKA can cause severe complications and even prove fatal. These recommendations, based on international and national guidelines, are designed to help healthcare professionals reduce the frequency and burden of DKA. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 18, 2020 Category: Nutrition Authors: Annunziata Lapolla, Flavia Amaro, Daniela Bruttomesso, Paolo Di Bartolo, Giorgio Grassi, Claudio Maffeis, Francesco Purrello, Stefano Tumini Tags: Systematic Reviews and Meta-analyses Source Type: research

The effects of Canola oil on cardiovascular risk factors: a systematic review and meta-analysis with dose-response analysis of controlled clinical trials
Canola oil (CO) is a plant-based oil with the potential to improve several cardio-metabolic risk factors. We systematically reviewed controlled clinical trials investigating effects of CO on lipid profiles, apo-lipoproteins, glycemic indices, inflammation, and blood pressure compared to other edible oils, in adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 18, 2020 Category: Nutrition Authors: Mojgan Amiri, Hamidreza Raeisi-Dehkordi, Nizal Sarrafzadegan, Scott C. Forbes, Amin Salehi-Abargouei Tags: Systematic Reviews and Meta-analyses Source Type: research

Effect of insulin Secretagogues on Major Cardiovascular events and all-cause mortality: a meta-analysis of randomized controlled trials
In 2019, the Italian Society of Diabetology and the Italian Association of Clinical Diabetologists nominated an expert panel to develop guidelines for drug treatment of type 2 diabetes. This expert panel, after identifying the effects of glucose-lowering agents on major adverse cardiovascular events (MACEs) and all-cause mortality as critical outcomes, decided to perform a systematic review and meta-analysis on the effect of insulin secretagogues (sulfonylureas and glinides) with this respect. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 16, 2020 Category: Nutrition Authors: Edoardo Mannucci, Matteo Monami, Riccardo Candido, Basilio Pintaudi, Giovanni Targher, SID-AMD joint panel for Italian Guidelines on Treatment of Type 2 Diabetes. The Panel is composed of Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 14, 2020 Category: Nutrition Source Type: research

The contribution of physical inactivity and socioeconomic factors to type 2 diabetes in Nepal: a structural equation modelling analysis
This study aimed to identify the path relationships between PA, socioeconomic position, anthropometric and metabolic variables and T2DM. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 13, 2020 Category: Nutrition Authors: Susan Paudel, Thach Tran, Alice J. Owen, Ben J. Smith Source Type: research

Longitudinal associations between metabolic score for visceral fat and hyperuricemia in non-obese adults
The assessment of visceral adiposity is of great significance for the prevention of hyperuricemia (HUA), especially in non-obese individuals. The metabolic score for visceral fat (METS-VF) is a newly proposed surrogate of visceral obesity. We aimed to evaluate the longitudinal associations of METS-VF with the risk of HUA in non-obese adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 12, 2020 Category: Nutrition Authors: Xing Zhen Liu, Dong Shui Chen, Xia Xu, Hui Hua Li, Lian Yong Liu, Lin Zhou, Jie Fan Source Type: research

Body Shape Trajectories And Mortality In The Seguimiento Universidad De Navarra (Sun) Cohort
The aim of this study was to assess the association between body shape trajectories and all-cause mortality in a Mediterranean cohort. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 12, 2020 Category: Nutrition Authors: Carmen Sayon-Orea, Maira Bes-Rastrollo, Mingyang Song, Dong Hang, Frank B. Hu, Miguel A. Martinez-Gonzalez Source Type: research

Reducing metabolic syndrome through a community-based lifestyle intervention in African American women
This study investigated the effectiveness of a community-based lifestyle intervention delivered by lay health coaches in reducing MetS among AA women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 12, 2020 Category: Nutrition Authors: Abdullah Mamun, Heather Kitzman, Leilani Dodgen Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 9, 2020 Category: Nutrition Source Type: research

Sodium-Glucose Co-Transporter-2 Inhibitors: Peculiar “Hybrid” Diuretics That Protect From Target Organ Damage And Cardiovascular Events
Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have been proven to lead to relevant cardiovascular benefits, regardless of glycemic control function. SGLT2i have on the one hand led to reduction in cardiovascular events such as heart failure and on the other hand to renal protection. Blood pressure reduction and kidney function play a central role in these outcomes. This focused review describes the main mechanisms and clinical aspects of SGLT2i. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 8, 2020 Category: Nutrition Authors: Riccardo Sarzani, Federico Giulietti, Chiara Di Pentima, Francesco Spannella Tags: Review Source Type: research

Relationship between Fermented Dairy Consumption, Circulating Short-chain Acylcarnitines and Angiographic Severity of Coronary Artery Disease
Current epidemiologic data suggest beneficial cardiovascular effects of fermented dairy products (FDP). However, the relationship between FDP consumption and angiographic coronary status has not been previously studied. Furthermore, the role of novel metabolomic biomarkers of cardiovascular risk in this context is unclear. We hypothesize that short-chain acylcarnitines (SCA) reflect the link between FDP intake and angiographic extent of stable coronary artery disease (CAD). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 8, 2020 Category: Nutrition Authors: Andrej Teren, Anika Vogel, Frank Beutner, Stephan Gielen, Ralph Burkhardt, Markus Scholz, Joachim Thiery, Uta Ceglarek Source Type: research

Conjugated linoleic acid supplements preserve muscle in high-body-fat adults: a double-blind, randomized, placebo trial
Conjugated linoleic acid (CLA) has been used to improve body composition in weight management. However, clinical trial results are inconsistent and limited among Asians. We aimed to investigate the effect of CLA on body composition of Chinese adults with elevated body fat percentage. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 7, 2020 Category: Nutrition Authors: Huan Chang, Wei Gan, Xia Liao, Junxiang Wei, Mengnan Lu, Huangtao Chen, Shenglong Wang, Yan Ma, Qian Wu, Yan Yu, Xin Liu Source Type: research

Carotid intimal medial thickness in rotating night shift is related to IL1 β/IL6 axis
sleep disturbances may promote glucose abnormalities and inflammatory burden among shift workers. Therefore, precocious subclinical atherosclerotic process might develop in healthy shift workers even without known metabolic and cardiovascular risk factors. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 7, 2020 Category: Nutrition Authors: Stefano Rizza, Susanna Longo, Giacomo Piciucchi, Daniele Romanello, Maria Mavilio, Martina Montagna, Luca Coppeta, Eugenio Martelli, Andrea Magrini, Massimo Federici Source Type: research

Association of weight-adjusted-waist index with incident hypertension: The Rural Chinese Cohort Study
We examined data for 10,338 non-hypertensive participants (39.49% men) aged ≥ 18 years from the Rural Chinese Cohort Study who completed a baseline examination during 2007-2008 and follow-up during 2013-2014. WWI was calculated as waist circumference (cm) divided by the square root of weight (kg). Multiple logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the probability of HTN across four WWI categories. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 7, 2020 Category: Nutrition Authors: Quanman Li, Ranran Qie, Pei Qin, Dongdong Zhang, Chunmei Guo, Qionggui Zhou, Gang Tian, Dechen Liu, Xu Chen, Leilei Liu, Feiyan Liu, Cheng Cheng, Minghui Han, Shengbing Huang, Xiaoyan Wu, Yang Zhao, Yongcheng Ren, Ming Zhang, Dongsheng Hu, Jie Lu Source Type: research

Mediterranean diet and All-cause mortality: A cohort of Italian men
The present study analyzes the relation between diet and all-cause mortality in a cohort of Italian men residing in different regions of Italy.The cohort was established using the members of the Associazione Nazionale Alpini, a voluntary organization that enlists individuals who have served in the Alpine troup; a mountain warfare infantry corps of the Italian Army.For the purpose of these analyses a total of 5049 participants were followed for an average of seven years. At baseline information was collected regarding age, education, life style habits, with special emphasis on diet (with the use of a validated dietary quest...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 7, 2020 Category: Nutrition Authors: Maurizio Trevisan, Vittorio Krogh, Sara Grioni Source Type: research

The association of waist-to-height ratio and other anthropometric measurements with subclinical atherosclerosis: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
To compare the performance of waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), waist circumference (WC) and Body-mass index (BMI) with subclinical atherosclerosis. Methods and results: The association of quintiles of anthropometric variables (1st as reference) - Odds ratio (OR); 95% Confidence Interval (95%CI) - with Coronary Artery Calcium (CAC: 0 vs.> 0; (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 4, 2020 Category: Nutrition Authors: Rosana Raele, Paulo A. Lotufo, Marcio S. Bittencourt, Maria de Jesus Fonseca, Alessandra C. Goulart, Itamar S. Santos, Isabela M. Bensenor Source Type: research