The β-Cell Burden Index of Food: a Proposal
The quantity and quality of dietary fat and/or carbohydrate may alter one or more of the basic components of the insulin-glucose system, which in turn affect the pathways leading to alterations in glucose homeostasis and, possibly, to cardiovascular disease.This viewpoint article, reviewing some of the currently available tools aiming at quantifying the impact of dietary carbohydrates on the glucose-insulin homeostatic loop, highlights the unmet need of a more thorough assessment of the complex interaction between dietary factors and the glucose-insulin system. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 6, 2016 Category: Nutrition Authors: Francesca Scazzina, Alessandra Dei Cas, Daniele Del Rio, Furio Brighenti, Riccardo C. Bonadonna Tags: Viewpoint Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 1, 2016 Category: Nutrition Source Type: research

Concordance of dietary sodium intake and concomitant phosphate load: Implications for sodium interventions
Both a high dietary sodium and high phosphate load are associated with an increased cardiovascular risk in patients with chronic kidney disease (CKD), and possibly also in non-CKD populations. Sodium and phosphate are abundantly present in processed food. We hypothesized that (modulation of) dietary sodium is accompanied by changes in phosphate load across populations with normal and impaired renal function. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 26, 2016 Category: Nutrition Authors: J.K. Humalda, C.A. Keyzer, S.H. Binnenmars, A.J. Kwakernaak, M.C.J. Slagman, G.D. Laverman, S.J.L. Bakker, M.H. de Borst, G.J. Navis Source Type: research

Concordance of Dietary Sodium Intake and Concomitant Phosphate Load: Implications for Sodium Interventions
Both a high dietary sodium and high phosphate load are associated with an increased cardiovascular risk in patients with chronic kidney disease (CKD), and possibly also in non-CKD populations. Sodium and phosphate are abundantly present in processed food. We hypothesized that (modulation of) dietary sodium is accompanied by changes in phosphate load across populations with normal and impaired renal function. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 26, 2016 Category: Nutrition Authors: J.K. Humalda, C.A. Keyzer, S.H. Binnenmars, A.J. Kwakernaak, M.C.J. Slagman, G.D. Laverman, S.J.L. Bakker, M.H. de Borst, G.J. Navis Source Type: research

Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis
Previous randomized clinical trials (RCTs) of the effects of vitamin D3 supplementation (VD3S) on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in a meta-analysis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 25, 2016 Category: Nutrition Authors: M. Golzarand, S. Shab-Bidar, G. Koochakpoor, R. Speakman J, K. Djafarian Tags: Systematic Reviews and Meta-analyses Source Type: research

Impact of lifestyle interventions on depressive symptoms in individuals at-risk of, or with, type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials
Depression affects one in four individuals with type 2 diabetes mellitus (T2DM). The impact of T2DM lifestyle interventions on depression is unclear. The aim of this analysis was to examine the influence of lifestyle interventions on depressive symptoms scores in individuals at-risk of or with T2DM. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 25, 2016 Category: Nutrition Authors: A. Cezaretto, S.R.G. Ferreira, S. Sharma, B. Sadeghirad, F. Kolahdooz Tags: Systematic reviews and meta-analyses Source Type: research

Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study
GPR120 (encoded by FFAR4) is a lipid sensor that plays an important role in the control of energy balance. GPR120 is activated by long chain fatty acids (FAs) including omega-3 FAs. In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels.The aim of this study was to investigate whether p.R270H interacts with dietary fat intake to modulate the risk of type 2 diabetes (T2D, 198 incident; 368 prevalent cases) and overweight (787 incident and 2891 prevalent cases) in the prospective D.E.S.I.R. (Sou...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 25, 2016 Category: Nutrition Authors: A. Lamri, A. Bonnefond, D. Meyre, B. Balkau, R. Roussel, M. Marre, P. Froguel, F. Fumeron, the D.E.S.I.R. Study Group Source Type: research

Effect of vitamin D3 supplementation on blood pressure in adults: an updated meta-analysis
Previous randomized clinical trials (RCTs) of vitamin D3 supplementation (VD3S) effects on blood pressure have generated inconsistent results. We evaluated the effect of VD3S on systolic and diastolic blood pressure in a meta-analysis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 25, 2016 Category: Nutrition Authors: M. Golzarand, S. Shab-Bidar, G. Koochakpoor, J. R. Speakman, K. Djafarian Tags: Systematic Reviews and Meta-analyses Source Type: research

Impact of lifestyle interventions on depressive symptoms in individuals at-risk of, or with, type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials
Depression affects one in four individuals with type 2 diabetes mellitus (T2DM). The impact of T2DM lifestyle interventions on depression is unclear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 25, 2016 Category: Nutrition Authors: Adriana Cezaretto, Sandra Roberta Gouvea Ferreira, Sangita Sharma, Behnam Sadeghirad, Fariba Kolahdooz Tags: Systematic Reviews and Meta-analyses Source Type: research

Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study
GPR120 (encoded by FFAR4) is a lipid sensor that plays an important role in the control of energy balance. GPR120 is activated by long chain fatty acids (FAs) including omega-3 FAs. In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels.The aim of this study was to investigate whether p.R270H interacts with dietary fat intake to modulate the risk of type 2 diabetes (T2D, 198 incident; 368 prevalent cases) and overweight (787 incident and 2891 prevalent cases) in the prospective D.E.S.I.R. (Sou...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 25, 2016 Category: Nutrition Authors: A. Lamri, A. Bonnefond, D. Meyre, B. Balkau, R. Roussel, M. Marre, P. Froguel, F. Fumeron, the D.E.S.I.R. study Group Source Type: research

Association of early protein intake and pre-peritoneal fat at five years of age: Follow-up of a randomized clinical trial
The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: D. Gruszfeld, M. Weber, K. Gradowska, P. Socha, V. Grote, A. Xhonneux, E. Dain, E. Verduci, E. Riva, R. Closa-Monasterolo, J. Escribano, B. Koletzko, the European Childhood Obesity Study Group Source Type: research

Serum β-cryptoxanthin and β-carotene derived from Satsuma mandarin and brachial–ankle pulse wave velocity: The Mikkabi cohort study
Findings of observational studies suggest cardioprotective effects of antioxidant vitamins and carotenoids. However, recent meta-analyses failed to show the beneficial effects of supplemental intake of antioxidants on cardiovascular disease (CVD). We aimed to assess the association between CVD risk and β-cryptoxanthin in Japan, where Satsuma mandarin, a major source of β-cryptoxanthin, is widely consumed. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: M. Nakamura, M. Sugiura, K. Ogawa, Y. Ikoma, M. Yano Source Type: research

The economic burden of severe hypoglycemia: Two sides of the same coin. Comment on G. Veronese and Coll. Costs associated with emergency care and hospitalization for severe hypoglycemia
Severe hypoglycemia is a marker of increased risk of death and a cause of significant clinical discomfort. Drugs with a relative lower risk of hypoglycemia are frequently preferred, when intensifying diabetes therapy, especially in older patients with multiple severe comorbidities, short life expectancy and suboptimal social and familiar support. However, hypoglycemia is an avoidable complication of diabetes therapy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: F. Gallo, D. Maggi, R. Cordera Tags: Letter to the Editor Source Type: research

Higher visceral to subcutaneous fat ratio is associated with small intestinal bacterial overgrowth
There is a lack of studies evaluating the association between small intestinal bacterial overgrowth (SIBO) and abdominal fat. The aim of this study was to evaluate whether visceral fat area (VFA), subcutaneous fat area (SFA) or visceral to subcutaneous fat ratio (VFA/SFA ratio) were associated with SIBO. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: A. Fialho, A. Fialho, P. Thota, A. McCullough, B. Shen Source Type: research

Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta
Advanced glycation end products (AGEs)-receptor RAGE interaction evokes oxidative stress and inflammatory reactions, thereby being involved in endothelial cell (EC) damage in diabetes. Sulforaphane is generated from glucoraphanin, a naturally occurring isothiocyanate found in widely consumed cruciferous vegetables, by myrosinase. Sulforaphane has been reported to protect against oxidative stress-mediated cell and tissue injury. However, effects of sulforaphane on AGEs-induced vascular damage remain unclear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: T. Matsui, N. Nakamura, A. Ojima, Y. Nishino, S.-i. Yamagishi Source Type: research

Serum β-cryptoxanthin and β-carotene derived from Satsuma mandarin and brachial–ankle pulse wave velocity: The Mikkabi cohort study
Findings of observational studies suggest cardioprotective effects of antioxidant vitamins and carotenoids. However, recent meta-analyses failed to show the beneficial effects of supplemental intake of antioxidants on cardiovascular disease (CVD). We aimed to assess the association between CVD risk and β-cryptoxanthin in Japan, where Satsuma mandarin, a major source of β-cryptoxanthin, is widely consumed. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: M. Nakamura, M. Sugiura, K. Ogawa, Y. Ikoma, M. Yano Source Type: research

Association of early protein intake and pre-peritoneal fat at five years of age: follow-up of a randomized clinical trial
The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: D. Gruszfeld, M. Weber, K. Gradowska, P. Socha, V. Grote, A. Xhonneux, E. Dain, E. Verduci, E. Riva, R. Closa-Monasterolo, J. Escribano, B. Koletzko, for the European Childhood Obesity Study Group European Childhood Obesity Project Group, J. Beyer, M. Fri Source Type: research

Serum β-cryptoxanthin and β-carotene derived from Satsuma mandarin and brachial-ankle pulse wave velocity: the Mikkabi cohort study
Findings of observational studies suggest cardioprotective effects of antioxidant vitamins and carotenoids. However, recent meta-analyses failed to show the beneficial effects of supplemental intake of antioxidants on cardiovascular disease (CVD). We aimed to assess the association between CVD risk and β-cryptoxanthin in Japan, where Satsuma mandarin, a major source of β-cryptoxanthin, is widely consumed. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: M. Nakamura, M. Sugiura, K. Ogawa, Y. Ikoma, M. Yano Source Type: research

The economic burden of severe hypoglycemia: two sides of the same coin. Comment on G. Veronese and Coll. Costs Associated With Emergency Care and Hospitalization for Severe Hypoglycemia. DOI 10.1016/j.numecd.2016.01.007
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: Gallo Fa, Maggi Da, Cordera Ra Source Type: research

Higher Visceral to Subcutaneous Fat Ratio is associated with Small Intestinal Bacterial Overgrowth
There is a lack of studies evaluating the association between small intestinal bacterial overgrowth (SIBO) and abdominal fat. The aim of this study was to evaluate whether visceral fat area (VFA), subcutaneous fat area (SFA) or visceral to subcutaneous fat ratio (VFA/SFA ratio) were associated with SIBO. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: Andre Fialho, Andrea Fialho, Prashanthi Thota, Arthur McCullough, Bo Shen Source Type: research

Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta
Advanced glycation end products (AGEs)-the receptor RAGE interaction evokes oxidative stress and inflammatory reactions, thereby being involved in endothelial cell (EC) damage in diabetes. Sulforaphane is generated from glucoraphanin, a naturally occurring isothiocyanate found in widely consumed cruciferous vegetables, by myrosinase. Sulforaphane has been reported to protect against oxidative stress-mediated cell and tissue injury. However, effects of sulforaphane on AGEs-induced vascular damage remain unclear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 20, 2016 Category: Nutrition Authors: Takanori Matsui, Nobutaka Nakamura, Ayako Ojima, Yuri Nishino, Sho-ichi Yamagishi Source Type: research

Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes – The TOSCA.IT study
Diabetic women have a more adverse plasma lipid profile than men. Sex differences in dietary habits may play a role, but are little investigated. The study evaluates the quality of diet, adherence to the nutritional recommendations of the Diabetes and Nutrition Study Group and their relation with plasma lipid in men and women with diabetes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 15, 2016 Category: Nutrition Authors: M. Vitale, M. Masulli, S. Cocozza, R. Anichini, A.C. Babini, M. Boemi, E. Bonora, R. Buzzetti, R. Carpinteri, C. Caselli, E. Ceccarelli, M. Cignarelli, G. Citro, G. Clemente, A. Consoli, L. Corsi, A. De Gregorio, P. Di Bartolo, G. Di Cianni, L. Fontana, M Source Type: research

Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes – The TOSCA.IT Study
Diabetic women have a more adverse plasma lipid profile than men. Sex differences in dietary habits may play a role, but are little investigated. The study evaluates the quality of diet, adherence to the nutritional recommendations of the Diabetes and Nutrition Study Group and their relation with plasma lipid in men and women with diabetes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 15, 2016 Category: Nutrition Authors: Marilena Vitale, Maria Masulli, Sara Cocozza, Roberto Anichini, Anna C. Babini, Massimo Boemi, Enzo Bonora, Raffaella Buzzetti, Rita Carpinteri, Chiara Caselli, Elena Ceccarelli, Mauro Cignarelli, Giuseppe Citro, Gennaro Clemente, Agostino Consoli, Laura Source Type: research

Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation
Moderately reduced maternal nutrient availability during pregnancy has adverse effects on the fetuses' growth and metabolism during and after pregnancy. The aim of this study was to explore effects of maternal nutrition restriction (MNR) on key metabolites of the fetal energy metabolism, particularly amino acids (AA), nonesterified fatty acids (NEFA), acylcarnitines and phospholipids. These effects may reflect mechanisms relating MNR to later adverse outcomes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 14, 2016 Category: Nutrition Authors: C. Hellmuth, O. Uhl, F.F. Kirchberg, U. Harder, W. Peissner, B. Koletzko, P.W. Nathanielsz Source Type: research

Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk
The role of the different factors associated with fatty liver is still poorly defined. We evaluated the relationships between liver fat content (LF) and metabolic, inflammatory and nutritional factors in a homogeneous cohort of individuals at high cardio-metabolic risk. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 14, 2016 Category: Nutrition Authors: L. Bozzetto, G. Annuzzi, M. Ragucci, O. Di Donato, Della Pepa G., G. Della Corte, E. Griffo, G. Anniballi, A. Giacco, M. Mancini, A.A. Rivellese Source Type: research

The role of Global and Regional DNA Methylation and Histone Modifications in glycemic traits and Type 2 Diabetes: a Systematic Review
New evidence suggests the potential involvement of epigenetic mechanisms in type 2 diabetes (T2D) as a crucial interface between the effects of genetic predisposition and environmental influences. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 14, 2016 Category: Nutrition Authors: Taulant Muka, Jana Nano, Trudy Voortman, Kim V.E. Braun, Symen Ligthart, Saverio Stranges, Wichor M. Bramer, John Troup, Rajiv Chowdhury, Abbas Dehghan, Oscar H. Franco Tags: Review Source Type: research

Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation
Moderately reduced maternal nutrient availability during pregnancy has adverse effects on the fetuses’ growth and metabolism during and after pregnancy. The aim of this study was to explore effects of maternal nutrition restriction (MNR) on key metabolites of the fetal energy metabolism, particularly amino acids (AA), nonesterified fatty acids (NEFA), acylcarnitines and phospholipids. These effects may reflect mechanisms relating MNR to later adverse outcomes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 14, 2016 Category: Nutrition Authors: Christian Hellmuth, Olaf Uhl, Franca F. Kirchberg, Ulrike Harder, Wolfgang Peissner, Berthold Koletzko, Peter Nathanielsz Source Type: research

Are elevated plasma amino acids causally linked to type 2 diabetes, or are they rather innocent bystanders?
It is generally known that the prevalence of type 2 diabetes (T2D) is increasing tremendously, reaching pandemic proportions. Most research to date is focussed on identifying therapeutic targets as well as predictive measures for T2D. Recently, Wang et al. have shown by metabolic profiling that elevated plasma amino acid concentrations (in particular the branched-chain amino acids [BCAAs] isoleucine, leucine and valine and the two aromatic amino acids phenylalanine and tyrosine) are predictive for developing T2D [1]. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 12, 2016 Category: Nutrition Authors: C.H. Oudt, R. Noordam, D. van Heemst Tags: Letter to the Editor Source Type: research

“Are elevated plasma amino acids causally linked to type 2 diabetes, or rather an innocent bystander?”
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 12, 2016 Category: Nutrition Authors: C.H. Oudt, R. Noordam, D. van Heemst Tags: Letter to the Editor Source Type: research

Branched-chain and aromatic amino acids, insulin resistance and liver specific ectopic fat storage in overweight to obese subjects
Amino acids may interfere with insulin action, particularly in obese individuals. We hypothesized that increased circulating branched-chain and aromatic amino acids herald insulin resistance and ectopic fat storage, particularly hepatic fat accumulation. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 6, 2016 Category: Nutrition Authors: S. Haufe, H. Witt, S. Engeli, J. Kaminski, W. Utz, J.C. Fuhrmann, D. Rein, J. Schulz-Menger, F.C. Luft, M. Boschmann, J. Jordan Source Type: research

The Olivetti Heart Study: Predictive value of a new adiposity index on risk of hypertension, blood pressure, and subclinical organ damage
Recently, some studies have indicated that a new anthropometric index, body adiposity index (BAI), could be more strongly correlated with the percentage of body fat than BMI. However, the results on its role in predicting cardiovascular risk were not univocal. Therefore, the aim of our study was to compare the predictive role of BMI and BAI on risk of hypertension (HP), blood pressure (BP) changes, and subclinical organ damage after an 8-year follow-up, in a sample of adult men participating in the Olivetti Heart Study. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 4, 2016 Category: Nutrition Authors: Lanfranco D’Elia, Martina Manfredi, Paola Sabino, Pasquale Strazzullo, Ferruccio Galletti Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 1, 2016 Category: Nutrition Source Type: research

Corrigendum to “Comparison of non-HDL-cholesterol versus triglycerides-to-HDLcholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children: The CARITALY study” [Nutr Metab Cardiovasc Dis 25 (2015) 489–494]
When this paper was first published the names of the CARITALY investigators who belong to the Childhood Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology, were incorrectly listed, they are printed correctly below: (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 1, 2016 Category: Nutrition Authors: P. Di Bonito, G. Valerio, G. Grugni, M.R. Licenziati, C. Maffeis, M. Manco, E. Miraglia del Giudice, L. Pacifico, M.C. Pellegrin, M. Tomat, M.G. Baroni, for the “CARdiometabolic risk factors in overweight and obese children in ITALY” (CARITALY) Study Tags: Corrigendum Source Type: research

Serum uric acid level and left ventricular hypertrophy in elderly male patients with nonvalvular atrial fibrillation
In this study, we investigated the association between SUA and cardiac hypertrophy in AF patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 30, 2016 Category: Nutrition Authors: W.Y. Liang, W.W. Liu, M.L. Liu, W. Xiang, X.R. Feng, B. Huang, X.H. Chen, Y.S. Sun Source Type: research

Suppression of plasma free fatty acids reduces myocardial lipid content and systolic function in type 2 diabetes
Type 2 diabetes (T2DM) is closely associated with the development of heart failure, which might be related with impaired substrate metabolism and accumulation of myocardial lipids (MYCL). The aim of this study was to investigate the impact of an acute pharmacological inhibition of adipose tissue lipolysis leading to reduced availability of circulating FFA on MYCL and heart function in T2DM. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 30, 2016 Category: Nutrition Authors: Peter Wolf, Yvonne Winhofer, Martin Krssak, Sabina Smajis, Jürgen Harreiter, Lana Kosi-Trebotic, Clemens Fürnsinn, Christian-Heinz Anderwald, Sabina Baumgartner-Parzer, Siegfried Trattnig, Anton Luger, Michael Krebs Source Type: research

Serum Uric Acid Level and Left Ventricular Hypertrophy in Old Male Patients with non-Valvular Atrial Fibrillation
In this study, we investigated the association between SUA and cardiac hypertrophy in AF patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 30, 2016 Category: Nutrition Authors: W.Y. Liang, W.W. Liu, M.L. Liu, W. Xiang, X.R. Feng, B. Huang, X.H. Chen, Y.S. Sun Source Type: research

Number of colony-forming unit-Hill colonies among children and teenagers with obesity, dyslipidemia and breastfeeding history
This study evaluates the associations between obesity, cardiovascular risk factors and breastfeeding history with the numbers of CFU-Hill colonies in a sample of young people. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 30, 2016 Category: Nutrition Authors: E. Salazar-Martinez, R. Rodriguez-Valentin, C. Albavera-Hernandez, A. Carreon-Rodriguez, E. Lazcano-Ponce Source Type: research

Effects of moderate beer consumption on health and disease: A consensus document
A large evidence-based review on the effects of a moderate consumption of beer on human health has been conducted by an international panel of experts who reached a full consensus on the present document.Low-moderate (up to 1 drink per day in women, up to 2 in men), non-bingeing beer consumption, reduces the risk of cardiovascular disease. This effect is similar to that of wine, at comparable alcohol amounts. Epidemiological studies suggest that moderate consumption of either beer or wine may confer greater cardiovascular protection than spirits. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 30, 2016 Category: Nutrition Authors: Giovanni de Gaetano, Simona Costanzo, Augusto Di Castelnuovo, Lina Badimon, Dritan Bejko, Ala’a Alkerwi, Gemma Chiva-Blanch, Ramon Estruch, Carlo La Vecchia, Salvatore Panico, George Pounis, Francesco Sofi, Saverio Stranges, Maurizio Trevisan, Fulvio Ur Tags: Review Source Type: research

Serum Phosphate modifies the vascular response to vitamin D receptor activation in Chronic Kidney Disease (CKD) patients
Vitamin D receptor activation (VDRA) ameliorates endothelial dysfunction in CKD patients but also increases phosphate and FGF-23, which may attenuate the beneficial effect of VDRA on endothelial function. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 25, 2016 Category: Nutrition Authors: C. Zoccali, C. Torino, G. Curatola, V. Panuccio, R. Tripepi, P. Pizzini, M. Versace, D. Bolignano, S. Cutrupi, L. Ghiadoni, R. Thadhani, G. Tripepi, F. Mallamaci Source Type: research

Association of heart rate and blood pressure among European adolescents with usual food consumption: the HELENA study
The objective of the present study was to examine the associations between heart rate, systolic (SBP), diastolic (DBP) and mean arterial blood pressure (MAP) among European adolescents and usual intake of vegetables, fruits, dairy products, meat, fish, high-sugar foods and savoury snacks. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 21, 2016 Category: Nutrition Authors: C. Julián-Almárcegui, S. Vandevijvere, F. Gottrand, L. Beghin, J. Dallongeville, M. Sjöstrom, C. Leclercq, Y. Manios, K. Widhalm, A.C. Ferreira De Morares, M. Gónzalez-Gross, P. Stehle, M.J. Castillo, L.A. Moreno, M. Kersting, K. Vyncke, S. De Henauw, Source Type: research

Associations of dairy products and meat consumption with retinal vessel calibers in subjects at increased cardiovascular risk
Association of dairy products and meat consumption with macrocirculation is previously described, but such association with microcirculation is poorly investigated. We aimed to test the hypothesis that consumption of high and low fat dairy products as well as of red, white and processed meat associates with retinal vessel calibers in adults at increased risk for cardiovascular disease (CVD). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 19, 2016 Category: Nutrition Authors: K. Karatzi, E.K. Aissopou, C. Tsirimiagou, E. Fatmeli, P.P. Sfikakis, A.D. Protogerou Source Type: research

Association of consumption of dairy products and meat with retinal vessel calibers in subjects at increased cardiovascular risk
Association of dairy products and meat consumption with macrocirculation is previously described, but such association with microcirculation is poorly investigated. We aimed to test the hypothesis that the consumption of high- and low-fat dairy products as well as red, white, and processed meat is associated with retinal vessel calibers in adults at an increased risk of cardiovascular disease (CVD). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 19, 2016 Category: Nutrition Authors: K. Karatzi, E.K. Aissopou, C. Tsirimiagou, E. Fatmeli, P.P. Sfikakis, A.D. Protogerou Source Type: research

Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: a case-control study
Iron metabolism plays a crucial role in the development of cardiometabolic disease, however, the association between cardiometabolic risk factors (CMRF) and hepcidin as well as other iron parameters remains unclear in children. The aims of this study were to compare circulating hepcidin level and iron metabolism between children with and without CMRF, and to explore the association between those iron parameters and CMRF. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 16, 2016 Category: Nutrition Authors: Y.N. Zhu, B.T. He, J. Jing, J. Ma, X.H. Li, W.H. Yang, Y. Jin, Y.J. Chen Source Type: research

Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control study
Iron metabolism plays a crucial role in the development of cardiometabolic disease; however, the association between cardiometabolic risk factors (CMRFs) and hepcidin as well as other iron parameters remains unclear in children. The aims of this study were to compare the circulating hepcidin levels and iron metabolism between children with and without CMRFs and to investigate the association between those iron parameters and CMRFs. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 16, 2016 Category: Nutrition Authors: Y.N. Zhu, B.T. He, J. Jing, J. Ma, X.H. Li, W.H. Yang, Y. Jin, Y.J. Chen Source Type: research

Serum uric acid levels during dual antiplatelet therapy with ticagrelor or clopidogrel: results from a single center study
New antithrombotic therapies have significantly improved the outcomes of patients with Acute Coronary Syndromes (ACS), where the introduction of ticagrelor has provided the greatest mortality benefits. However, ticagrelor treatment has been associated with a potential raise in serum uric acid (SUA), whose contribution to endothelial dysfunction and pro-thrombotic status may affect the risk of acute cardiovascular events in patients requiring dual antiplatelet therapy (DAPT). The aim of the present study was to compare the impact of the antiplatelet agents ticagrelor or clopidogrel on SUA levels and their effect on platelet...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 14, 2016 Category: Nutrition Authors: Matteo Nardin, Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Lucia Barbieri, Alon Schaffer, Paolo Marino, Giorgio Bellomo, Harry Suryapranata, Giuseppe De Luca, the Novara Atherosclerosis Study Group (NAS) Source Type: research

Lack of effect of supplementation with EPA or DHA on platelet-monocyte aggregates and vascular function in healthy men. 1-3
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil are postulated to have favourable effects on platelet, endothelial and vascular function. We investigated whether EPA has differential effects on in vivo platelet aggregation and other markers of cardiovascular risk compared to DHA. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 14, 2016 Category: Nutrition Authors: S.C. Cottin, A. Alsaleh, T.A.B. Sanders, W.L. Hall Source Type: research

Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus
Progressive microvascular dysfunction in type 2 diabetes mellitus (T2DM) may impair the ability of cerebral vessels to supply blood to brain regions during local metabolic demand, thereby increasing risks of dementia. Having previously demonstrated that resveratrol can enhance vasodilator function in the systemic circulation, we hypothesised that resveratrol could similarly benefit the cerebral circulation. We aimed to determine the most efficacious dose of resveratrol to improve cerebral vasodilator responsiveness (CVR) in T2DM. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 14, 2016 Category: Nutrition Authors: R.H.X. Wong, R.S. Nealon, A. Scholey, P.R.C. Howe Source Type: research

Lack of effect of supplementation with EPA or DHA on platelet-monocyte aggregates and vascular function in healthy men
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil are postulated to have favourable effects on platelet, endothelial and vascular function. We investigated whether EPA has differential effects on in  vivo platelet aggregation and other markers of cardiovascular risk compared to DHA. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 14, 2016 Category: Nutrition Authors: S.C. Cottin, A. Alsaleh, T.A.B. Sanders, W.L. Hall Source Type: research

DPP-4 Inhibitors and Cardiovascular Disease in Type 2 Diabetes Mellitus. Expectations, Observations and Perspectives
Cardiovascular disease (CVD) is the greatest burden of type 2 diabetes mellitus (T2DM) in terms of morbility, mortality and costs for individuals and societies. Therefore, its prevention is a major goal in diabetes care. Optimal treatment of hyperglycemia is certainly instrumental to CVD prevention. Optimal treatment means both establishing the most appropriate glycemic target for the given individual and selecting the medication(s) with the most favourable benefit/safety ratio. CVD safety, if not a clear CVD benefit, is certainly required for all antidiabetic agents. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 12, 2016 Category: Nutrition Authors: Enzo Bonora, Massimo Cigolini Tags: Review Source Type: research