Flavanols are potential anti-obesity agents, a systematic review and meta-analysis of controlled clinical trials
The anti-obesity potential of flavonoids has been shown by animal and human studies. In this meta-analysis, we systematically reviewed controlled clinical trials and quantified the effects of flavonoids and flavonoid subclasses on obesity-related anthropometric measures. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 13, 2018 Category: Nutrition Authors: Masoumeh Akhlaghi, Saeed Ghobadi, Mona Mohammad Hosseini, Zohreh Gholami, Fatemeh Mohammadian Tags: Systematic Reviews and Meta-analyses Source Type: research

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause
Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 9, 2018 Category: Nutrition Authors: Thozhukat Sathyapalan, Myint Aye, Alan S. Rigby, Natalie J. Thatcher, Soha R. Dargham, Eric S. Kilpatrick, Stephen L. Atkin Source Type: research

Sex disparity persists in the prevention of cardiovascular disease in women on statin therapy compared to that in men
The aim of this study was to assess whether women differ from men with regard to lowering lipid levels, achieving target of optimal lipid levels, and analyzing evidence-based dose and intensity of statin prescription in primary care patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 7, 2018 Category: Nutrition Authors: S. Moreno-Arellano, J. Delgado-de-Mendoza, M.J. Santi-Cano Source Type: research

The sex disparity persists in prevention of cardiovascular disease in women with statin therapy compared with men.
To assess whether women differ from men with regard to lipid lowering, achieving optimal lipid goals and evidence-based intensity statin prescription, in primary care patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 7, 2018 Category: Nutrition Authors: S. Moreno-Arellano, J. Delgado- de-Mendoza, M.J. Santi-Cano Source Type: research

Cost-Effectiveness of Sensor-Augmented Pump Therapy in Two Different Patient Populations with Type 1 Diabetes in Italy
Sensor-augmented pump therapy (SAP) combines real time continuous glucose monitoring (CGM) with Continuous Subcutaneous Insulin Infusion (CSII) and provides additional benefits beyond those provided by CSII alone. SAP with automated insulin suspension provides early warning of the onset of hyperglycemia and hypoglycemia and has the functionality to suspend insulin delivery if sensor glucose levels are predicted to fall below a predefined threshold. Aim of this study was to assess the cost-effectiveness of SAP with automated insulin suspension versus CSII alone in type 1 diabetes. (Source: Nutrition, Metabolism, and Cardiov...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 5, 2018 Category: Nutrition Authors: Nicolucci A, Rossi MC, D ’Ostilio D, Delbaere A, de Portu S, Roze S Source Type: research

Congruent validity and inter-day reliability of two breath by breath metabolic carts to measure resting metabolic rate in young adults
Achieving high inter-day reliability is a key factor to analyze the magnitude of change in RMR, for instance after an intervention. The aims of this study were: i) to determine the congruent validity of RMR and respiratory quotient (RQ) with two breath by breath commercially available metabolic carts [CCM Express (CCM) and Ultima CardiO2 (MGU)]; and ii) to analyze the inter-day reliability of RMR and RQ measurements. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 30, 2018 Category: Nutrition Authors: J.M.A. Alcantara, G. Sanchez-Delgado, B. Martinez-Tellez, E. Merchan-Ramirez, I. Labayen, J.R. Ruiz Source Type: research

Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: a randomized 1-year trial
Long-term adherence to conventional weight-loss diets is limited while intermittent fasting has risen in popularity. We compared the effects of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk factors in adults with abdominal obesity and ≥1 additional component of metabolic syndrome. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 29, 2018 Category: Nutrition Authors: T.M. Sundf ør, M. Svendsen, S. Tonstad Source Type: research

High-sensitivity c-reactive protein, low-grade systemic inflammation and type 2 diabetes mellitus: A two-sample Mendelian randomization study
The role of inflammation in type 2 diabetes mellitus (T2D) remains unclear. We investigated the associations of high sensitivity c-reactive protein (hsCRP) concentration with T2D and glycemic traits using two-sample Mendelian Randomization. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 26, 2018 Category: Nutrition Authors: Raymond Noordam, Charlotte H. Oudt, Maxime M. Bos, Roelof AJ. Smit, Diana van Heemst Source Type: research

BMI correlates with pulse pressure in offspring of patients with type 2 diabetes and albuminuria
High pulse pressure (PP), a proxy of arterial stiffness, has been linked to cardiovascular events (CVE) in diabetic and non-diabetic population [1,2], and to albuminuria in diabetic subjects [3,4]. The increasing body mass index (BMI) affects arterial compliance and consequently PP [5]. Offspring of albuminuric parents with T2DM showed a higher BMI and albuminuria, than offspring of normoalbuminuric parents [6]. Therefore, BMI, PP and albuminuria may be related to each other. Moreover, all of them are heritable traits and could share some genetic background. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 22, 2018 Category: Nutrition Authors: S. Bacci, A. di Lorenzo, E.V. Greco, M.G. Tinti, A. Rauseo, A.P. Palena, G. Vendemiale, S. De Cosmo Tags: Letter to the Editor Source Type: research

The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis
Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 22, 2018 Category: Nutrition Authors: Nazli Namazi, Bagher Larijani, Pamela J. Surkan, Leila Azadbakht Source Type: research

BMI correlates with pulse pressure in offspring of patients with type 2 diabetes and albuminuria
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 22, 2018 Category: Nutrition Authors: Simonetta Bacci Source Type: research

The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis
Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 22, 2018 Category: Nutrition Authors: Nazli Namazi, Bagher Larijani, Pamela J. Surkan, Leila Azadbakht Source Type: research

A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects
High-cholesterol and high-fat diets alter biochemical composition and anti-oxidant properties of high-density lipoproteins (HDL) in animals. Whether this occurs in humans is unknown. Therefore, we examined the effect of a short-term elevation in dietary cholesterol and fat intake on HDL composition in healthy subjects. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 19, 2018 Category: Nutrition Authors: C. Morgantini, S. Trifir ò, D. Tricò, D. Meriwether, S. Baldi, A. Mengozzi, S.T. Reddy, A. Natali Source Type: research

Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring
Maternal high fat diets (mHFD) have been associated with an increased offspring cardiovascular risk. Recently we found that the class IIa HDAC-MEF2 pathway regulates gene programs controlling fatty acid oxidation in striated muscle. This same pathway controls hypertrophic responses in the heart. We hypothesized that mHFD is associated with activation of signal controlling class II a HDAC activity and activation of genes involved in fatty acid oxidation and cardiac hypertrophy in offspring. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 13, 2018 Category: Nutrition Authors: K.A. De Jong, S. Barrand, R.J. Wood-Bradley, D.L. de Almeida, J.K. Czeczor, G.D. Lopaschuk, J.A. Armitage, S.L. McGee Source Type: research

Lower C-reactive protein and IL-6 associated with vegetarian diets are mediated by BMI
The mechanism by which vegetarian diets are associated with less inflammation is not clear. We investigated the role of BMI as a mediator in the relationship between vegetarian diet and concentrations of C-reactive protein (CRP), and the cytokines IL-6, IL-10 and TNF- α. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 13, 2018 Category: Nutrition Authors: K. Jaceldo-Siegl, E. Haddad, S. Knutsen, J. Fan, J. Lloren, D. Bellinger, G.E. Fraser Source Type: research

Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals
Persons with “metabolically healthy” obesity may develop cardiometabolic complications at a lower rate than equally obese persons with evident metabolic syndrome. Even morbidly obese individuals vary in risk profile. Persistent organic pollutants (POPs) are widespread environmental chemicals that impair meta bolic homeostasis. We explored whether prevalence of metabolic syndrome in morbidly obese individuals is associated with serum concentrations of POPs. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 13, 2018 Category: Nutrition Authors: S. Dusanov, J. Ruzzin, H. Kiviranta, T.O. Klemsdal, L. Retterst øl, P. Rantakokko, R. Airaksinen, S. Djurovic, S. Tonstad Source Type: research

Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring
Maternal high fat diets (mHFD) have been associated with an increased offspring cardiovascular risk. Recently we found that the class IIa HDAC-MEF2 pathway regulates gene programs controlling fatty acid oxidation in striated muscle. This same pathway controls hypertrophic responses in the heart. We hypothesized that mHFD is associated with activation of signal controlling class II a HDAC activity and activation of genes involved in fatty acid oxidation and cardiac hypertrophy in offspring. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 13, 2018 Category: Nutrition Authors: Kirstie A. De Jong, Sanna Barrand, Ryan J. Wood-Bradley, Douglas L. de Almeida, Juliane K. Czeczor, Gary D. Lopaschuk, James A. Armitage, Sean L. McGee Source Type: research

Lower C-reactive protein and IL-6 associated with vegetarian diets are mediated by BMI
The mechanism by which vegetarian diets are associated with less inflammation is not clear. We investigated the role of BMI as a mediator in the relationship between vegetarian diet and concentrations of C-reactive protein (CRP), and the cytokines IL-6, IL-10 and TNF- α. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 13, 2018 Category: Nutrition Authors: K. Jaceldo-Siegl, E. Haddad, S. Knutsen, J. Fan, J. Lloren, D. Bellinger, G.E. Fraser Source Type: research

Associations between Persistent Organic Pollutants and Metabolic Syndrome in Morbidly Obese Individuals
Persons with “metabolically healthy” obesity may develop cardiometabolic complications at a lower rate than equally obese persons with evident metabolic syndrome. Even morbidly obese individuals vary in risk profile. Persistent organic pollutants (POPs) are widespread environmental chemicals that impair meta bolic homeostasis. We explored whether prevalence of metabolic syndrome in morbidly obese individuals is associated with serum concentrations of POPs. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 13, 2018 Category: Nutrition Authors: S. Dusanov, J. Ruzzin, H. Kiviranta, T.O. Klemsdal, L. Retterst øl, P. Rantakokko, R. Airaksinen, S. Djurovic, S. Tonstad Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 11, 2018 Category: Nutrition Source Type: research

The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: a 10-week randomized controlled trial
The objective was to determine the effects of daily consumption of a fortified yogurt (FSY) on weight loss in overweight and obese patients with metabolic syndrome on a caloric-restricted diet. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 9, 2018 Category: Nutrition Authors: Mohsen Mohammadi-Sartang, Nick Bellissimo, Julia O. Totosy de Zepetnek, Neil R. Brett, Seyed Mohammad Mazloomi, Mohammad Fararouie, Alireza Bedeltavana, Mandana Famouri, Zohreh Mazloom Source Type: research

DXA-measured visceral fat mass and lean body mass reflect abnormal metabolic phenotypes among some obese and nonobese Chinese children and adolescents
The exact constellation of body composition characteristics among metabolically unhealthy obese (MUO) and nonobese (MUNO) children and adolescents remains unclear. The purpose of this study was to identify the major body composition determinants of metabolically unhealthy phenotypes among Chinese children and adolescents. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 9, 2018 Category: Nutrition Authors: W.Q. Ding, J.T. Liu, Y.X. Shang, B. Gao, X.Y. Zhao, H.P. Zhao, W.J. Wu Source Type: research

The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: a 10-week randomized controlled trial
The objective was to determine the effects of daily consumption of a fortified yogurt (FSY) on weight loss in overweight and obese patients with metabolic syndrome on a caloric-restricted diet. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 9, 2018 Category: Nutrition Authors: Mohsen Mohammadi-Sartang, Nick Bellissimo, Julia O. Totosy de Zepetnek, Neil R. Brett, Seyed Mohammad Mazloomi, Mohammad Fararouie, Alireza Bedeltavana, Mandana Famouri, Zohreh Mazloom Source Type: research

DXA-measured visceral fat mass and lean body mass reflect abnormal metabolic phenotypes among some obese and non-obese Chinese children and adolescents
The exact constellation of body composition characteristics among metabolically unhealthy obese (MUO) and non-obese (MUNO) children and adolescents remains unclear. The purpose of this study was to identify the major body composition determinants of metabolically unhealthy phenotypes among Chinese children and adolescents. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 9, 2018 Category: Nutrition Authors: W.Q. Ding, J.T. Liu, Y.X. Shang, B. Gao, X.Y. Zhao, H.P. Zhao, W.J. Wu Source Type: research

Angiotensin receptor blocker vs ACE inhibitor effects on HDL functionality in patients on maintenance hemodialysis
Angiotensin receptor blockers (ARB) and angiotensin converting enzyme inhibitors (ACEI) reduce cardiovascular events in the general population. Maintenance hemodialysis (MHD) patients are at high cardiovascular risk but few studies have directly addressed the comparative efficacy of these drugs. MHD disrupts the normally atheroprotective actions of high density lipoprotein (HDL), therefore, we compared ACEI or ARB treatment on HDL functions in MHD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 8, 2018 Category: Nutrition Authors: R. Kaseda, Y. Tsuchida, J.L. Gamboa, J. Zhong, L. Zhang, H. Yang, A. Dikalova, A. Bian, S. Davies, A.F. Fogo, M.F. Linton, N.J. Brown, T.A. Ikizler, V. Kon Source Type: research

Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: The Study of Novel Approaches to Weight Gain Prevention (SNAP)
We examined whether weight gain prevention blunts genetic risk for body weight increase and/or high density lipoprotein cholesterol (HDL-C) lowering over two years. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 6, 2018 Category: Nutrition Authors: J.M. McCaffery, J.M. Ordovas, G.S. Huggins, C.-Q. Lai, M.A. Espeland, D.F. Tate, R.R. Wing Source Type: research

Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: The Study of Novel Approaches to Weight Gain Prevention (SNAP)
We examined whether weight gain prevention blunts genetic risk for body weight increase and/or high density lipoprotein cholesterol (HDL-C) lowering over two years. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 6, 2018 Category: Nutrition Authors: Jeanne M. McCaffery, Jose M. Ordovas, Gordon S. Huggins, Chao-Qiang Lai, Mark A. Espeland, Deborah F. Tate, Rena R. Wing Source Type: research

Attending Diabetes Clinics is associated with a lower all-cause mortality. A meta-analysis of observational studies performed in Italy
The epidemiological explosion of diabetes is a challenge for Health Systems and the identification of the most appropriate models of care are warranted. The inclusion of primary care physicians in the models is unquestioned whereas the role played by secondary and tertiary care (Diabetes Clinic) is often debated. However, studies focusing on hard endpoints and comparing Diabetes Clinic attendance vs. no attendance are scant. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 2, 2018 Category: Nutrition Authors: E. Bonora, M. Monami, G. Bruno, G. Zoppini, E. Mannucci Tags: Meta-analysis Source Type: research

Prognostic usefulness of arm circumference and nutritional screening tools in older patients with cardiovascular disease
This study aimed to compare the prognostic predictive capabilities of AC and nutritional screening tools in older patients with CVD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 2, 2018 Category: Nutrition Authors: T. Nakamura, K. Kamiya, A. Matsunaga, N. Hamazaki, R. Matsuzawa, K. Nozaki, S. Tanaka, M. Yamashita, E. Maekawa, C. Noda, M. Yamaoka-Tojo, T. Masuda, J. Ako Source Type: research

Attending Diabetes Clinics is associated with a lower all-cause mortality. A meta-analysis of observational studies performed in Italy
The epidemiological explosion of diabetes is a challenge for Health Systems and the identification of the most appropriate models of care are warranted. The inclusion of primary care physicians in the models is unquestioned whereas the role played by secondary and tertiary care (Diabetes Clinic) is often debated. However, studies focusing on hard endpoints and comparing Diabetes Clinic attendance vs. no attendance are scant. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 2, 2018 Category: Nutrition Authors: E. Bonora, M. Monami, G. Bruno, G. Zoppini, E. Mannucci Tags: Systematic Reviews and Meta-analyses Source Type: research

Attendance to Diabetes Clinics is associated with a lower all-cause mortality. A meta-analysis of observational studies performed in Italy
The epidemiological explosion of diabetes is a challenge for Health Systems and the identification of the most appropriate models of care are warranted. The inclusion of primary care physicians in the models is unquestioned whereas the role played by secondary and tertiary care (diabetes clinic) is often debated. However, studies focusing on hard endpoints and comparing diabetes clinic attendance vs. no attendance are scant. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 2, 2018 Category: Nutrition Authors: Enzo Bonora, Matteo Monami, Graziella Bruno, Giacomo Zoppini, Edoardo Mannucci Tags: Systematic Reviews and Meta-analyses Source Type: research

Prognostic usefulness of arm circumference and nutritional screening tools in older patients with cardiovascular disease
This study aimed to compare the prognostic predictive capabilities of AC and nutritional screening tools in older patients with CVD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 2, 2018 Category: Nutrition Authors: T. Nakamura, K. Kamiya, A. Matsunaga, N. Hamazaki, R. Matsuzawa, K. Nozaki, S. Tanaka, M. Yamashita, E. Maekawa, C. Noda, M. Yamaoka-Tojo, T. Masuda, J. Ako Source Type: research

Pharmacovigilance of sodium-glucose co-transporter-2 inhibitors: What a clinician should know on disproportionality analysis of spontaneous reporting systems
Sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) have consistently demonstrated a clinically significant reduction of cardiovascular mortality. However, their safety in clinical practice is still incompletely characterized, and post-marketing monitoring is required considering the expected increase in clinical use. Different analyses of international spontaneous reporting systems, known as disproportionality analyses (DAs), have highlighted the occurrence of ketoacidosis, amputations, acute renal failure and skin toxicity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 1, 2018 Category: Nutrition Authors: E. Raschi, E. Poluzzi, F. Salvo, A. Pariente, F. De Ponti, G. Marchesini, U. Moretti Tags: Viewpoint Source Type: research

Fasting and post-glucose load measures of insulin resistance and risk of incident atrial fibrillation: The Cardiovascular Health Study
Existing literature in individuals without diabetes has not demonstrated a relationship between IR and incident AF; however, data are limited and only fasting glucose measures of IR were assessed. We evaluated the relationship of both fasting and post-glucose load IR measures with the development of atrial fibrillation in nondiabetic older adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 1, 2018 Category: Nutrition Authors: P.K. Garg, M.L. Biggs, R. Kaplan, J.R. Kizer, S.R. Heckbert, K.J. Mukamal Source Type: research

B-type natriuretic peptide may predict prognosis in older adults admitted with a diagnosis other than heart failure
The diagnosis of heart failure (HF) in elderly patients is often difficult, due to overlap of typical signs and symptoms with those of comorbidities. B-type Natriuretic Peptide (BNP) predicts diagnosis and prognosis of HF, but little is known on its predictive role of short-term prognosis when admission diagnosis is other than HF. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 1, 2018 Category: Nutrition Authors: S. Di Marca, A. Rando, E. Cataudella, A. Pulvirenti, S. Alaimo, V. Terranova, T. Corriere, M. Pisano, R. Di Quattro, M.L. Ronsisvalle, C.M. Giraffa, M. Giordano, B. Stancanelli, L. Malatino Source Type: research

Pharmacovigilance of sodium-glucose co-transporter-2 inhibitors: What a clinician should know on disproportionality analysis of spontaneous reporting systems
Sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) have consistently demonstrated a clinically significant reduction of cardiovascular mortality. However, their safety in clinical practice is still incompletely characterized, and post-marketing monitoring is required considering the expected increase in clinical use. Different analyses of international spontaneous reporting systems, known as disproportionality analyses (DAs), have highlighted the occurrence of ketoacidosis, amputations, acute renal failure and skin toxicity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 1, 2018 Category: Nutrition Authors: Emanuel Raschi, Elisabetta Poluzzi, Francesco Salvo, Antoine Pariente, Fabrizio De Ponti, Giulio Marchesini, Ugo Moretti Tags: Viewpoint Source Type: research

Fasting and Post-Glucose Load Measures of Insulin Resistance and Risk of Incident Atrial Fibrillation: The Cardiovascular Health Study
Existing literature in individuals without diabetes has not demonstrated a relationship between IR and incident AF; however, data are limited and only fasting glucose measures of IR were assessed. We evaluated the relationship of both fasting and post-glucose load IR measures with the development of atrial fibrillation in nondiabetic older adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 1, 2018 Category: Nutrition Authors: Parveen K. Garg, Mary L. Biggs, Robert Kaplan, Jorge R. Kizer, Susan R. Heckbert, Kenneth J. Mukamal Source Type: research

B-Type Natriuretic Peptide May Predict Prognosis In Older Adults Admitted With A Diagnosis Other Than Heart Failure
The diagnosis of heart failure (HF) in elderly patients is often difficult, due to overlap of typical signs and symptoms with those of comorbidities. B-type Natriuretic Peptide (BNP) predicts diagnosis and prognosis of HF, but little is known on its predictive role of short-term prognosis when admission diagnosis is other than HF. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 1, 2018 Category: Nutrition Authors: S. Di Marca, A. Rando, E. Cataudella, A. Pulvirenti, S. Alaimo, V. Terranova, T. Corriere, M. Pisano, R. Di Quattro, M.L. Ronsisvalle, C.M. Giraffa, M. Giordano, B. Stancanelli, L. Malatino Source Type: research

N-terminal pro B-Type natriuretic peptide is inversely correlated with low density lipoprotein cholesterol in the very elderly
Laboratory studies on human adipose tissue and differentiated adipocytes indicate that natriuretic peptides (NPs) affect lipid metabolism and plasma cholesterol. Few previous clinical studies in non-elderly populations found associations between NPs in the physiological range and cholesterol. Aim: evaluate the association between NT-proBNP and lipid profile in very elderly hospitalized patients characterized by a wide range of NT-proBNP levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 27, 2018 Category: Nutrition Authors: F. Spannella, F. Giulietti, G. Cocci, L. Landi, E. Borioni, F.E. Lombardi, G. Rosettani, B. Bernardi, V. Bordoni, P. Giordano, M. Bordicchia, R. Sarzani Source Type: research

N-Terminal Pro B-Type Natriuretic Peptide Is Inversely Correlated With Low Density Lipoprotein Cholesterol In The Very Elderly
Laboratory studies on human adipose tissue and differentiated adipocytes indicate that natriuretic peptides (NPs) affect lipid metabolism and plasma cholesterol. Few previous clinical studies in non-elderly populations found associations between NPs in the physiological range and cholesterol. Aim: evaluate the association between NT-proBNP and lipid profile in very elderly hospitalized patients characterized by a wide range of NT-proBNP levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 27, 2018 Category: Nutrition Authors: F. Spannella, F. Giulietti, G. Cocci, L. Landi, E. Borioni, Fe Lombardi, G. Rosettani, B. Bernardi, V. Bordoni, P. Giordano, M. Bordicchia, R. Sarzani Source Type: research

Long-acting insulin analogs and cancer
Hyperinsulinemia is a recognized risk factor for cancer and plays a major role for the  increased cancer incidence in diabetic patients. Whether insulin analogs, and particularly long-acting analogs, worsen the pro-cancer effect of excess insulin is still controversial. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 24, 2018 Category: Nutrition Authors: L. Sciacca, V. Vella, L. Frittitta, A. Tumminia, L. Manzella, S. Squatrito, A. Belfiore, R. Vigneri Tags: Review Source Type: research