Bicuspid aortic valve and Lipoprotein (a)
Background: In bicuspid aortic valve (BAV), the most frequent congenital cardiopathy, the presence of calcification and stenosis (SAo) predicts a worse prognosis. In our study, we investigated the association between Lp(a) levels, kringle IV type 2 (KIV2) repeat number polymorphism, and the presence of calcification in BAV patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: E. Sticchi, A. Cordisco, B. Giusti, S. Nistri, A. Sereni, R. De Cario, R. Di Carlo, A. Kura, A.M. Gori, M.G. D'Alfonso, V. Mecarocci, N. Marchionni, G. Pepe, F. Mori, R. Marcucci Source Type: research

Relationships between arterial stiffness and bone mineral density in postmenopausal women
Background: Although osteoporosis and Cardiovascular disease have always been considered as separate entities, there is accumulated evidence that they have several pathological mechanisms in common. However, little research has been conducted to examine the relationship between arterial stiffness and bone mineral density (BMD) in post-menopausal women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: A. Tafa, A. Giambelluca, C. Caffarelli, C. Pondrelli, S. Cappelli, S. Gonnelli Source Type: research

Metabolomics by Nuclear Magnetic Resonance identifies patients with high risk of death within two years after a cardiovascular event: The case of the amiflorence II study
Background: Risk stratification and management of patients with acute coronary syndromes (ACS) is challenging. Aim of this study was to evaluate the possible role of metabolomics in the prognostic stratification of ACS patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: L. Tenori, B. Giusti, A. Vignoli, A.M. Gori, C. Luchinat, E. Grifoni, A. Barchielli, D. Balzi, N. Marchionni, R. Marcucci Source Type: research

Use of evolocumab in a patient with homozygous familial hypercholesterolemia
Introduction: Homozygous familial hypercholesterolemia (FH) is a rare (1:160.000-360.000) but serious disorder with a substantial reduction in low-density lipoprotein receptor (LDLR) function, severely elevated low-density lipoprotein cholesterol (LDL-C), cardiovascular disease, and often death in early decades of life. Response to conventional lipid-lowering agents is modest. Novel monoclonal antibodies to proprotein convertase subtilisin/kexin 9 (PCSK9) have shown ability to substantially reduce LDL-C in heterozygous familial hypercholesterolemia. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: C. Trenti, E.A. Negri, M.C. Leone, A. Muoio, D. Galimberti, T.A. Pertinhez, D. Farioli, N. Romano, R. Baricchi, L. Vecchia, C. Rabacchi, S. Calandra, T. Fasano Source Type: research

Association between Lp (a) and small dense LDL in menopausal women without Metabolic Syndrome
The association between Lipoprotein (a) (Lp [a]) and small dense LDL (sd-LDL) has been evaluated in 129 menopausal women, without Metabolic Syndrome (MS), living in the area of Naples (Italy) participating to a large (N=5.062) epidemiological Study from 1993 (Progetto Atena). Lp (a) was measured by an ELISA, solid phase two-site enzyme immunoassay, using polyclonal antibodies raised against purified Lp(a) (Mercodia Diagnostics, Uppsala, Sweden), LDL particle separation was performed by Lipoprint System: seven LDL subfractions were obtained and LDL score (% of sd-LDL particles) calculated. (Source: Nutrition, Metabolism, an...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: M. Tripaldella, M. Gentile, F. Jossa, G. Marotta, G. Iannuzzo, A. Buonaiuto, E.L. Fata, S. Panico, A. Mattiello, P. Rubba Source Type: research

The PREDIMED score: Index of adherence to the Mediterranean diet in the general population: the PLIC study
Introduction: Interventional randomized studies have demonstrated the association between adherence to the Mediterranean diet and a reduced risk of cardiovascular events. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: C. Visinoni, L. Redaelli, A. Baragetti, K. Garlaschelli, L. Grigore, G.D. Norata, A.L. Catapano Source Type: research

Familial hypercholesterolemia: Development of a research and diagnostic approach to the disease
Background: Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD) due to life-long elevated plasma LDL cholesterol levels. FH is caused by mutations in LDLR, APOB and PCSK9 genes found in 80%, 5%, and 1%, respectively, of FH subjects. However, many subjects with primary hypercholesterolemia did not demonstrate functional mutations in any of these genes. In a substantial proportion of FH patients without a known mutation, their high LDL-C concentrations might have a polygenic cause. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: A. Volta, E. Sticchi, A.M. Gori, E. Grifoni, R. Marcucci, B. Giusti Source Type: research

Risk awareness in ProSALUTE, a new community program for cardiovascular health in Milan, Italy
Background: Awareness of the own cardiovascular (CV) risk is a prerequisite to follow preventive actions. Risk awareness requires health literacy and self-knowledge, and both depend on many context-specific factors. ProSALUTE is an experimental CV health program for the medium/low-income and multi-ethnic community of the Ponte Lambro district, Milan, Italy (n=3600 adults). CV risk domains are assessed through an assisted questionnaire and objective anthropometric and laboratory measures are obtained to estimate CV risk and to propose personalized interventions. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: J.P. Werba, M. Giroli, N. Simonelli, L. Vigo, M. Amato, A. Gorini, A. Bonomi, F. Veglia, E. Tremoli Source Type: research

Early adopters of a free-access primary cardiovascular prevention program in a multiethnic community in North Italy
Background: Primary cardiovascular prevention programs (PPP) may be more effective by addressing disadvantaged people. Yet, their participation in PPP is low. Shift to multi-ethnicity and deprivation in populations call for inclusive strategies to reduce CVD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: J.P. Werba, L. Vigo, A. Bonomi, N. Simonelli, M.G. Giroli, M. Amato, A. Gorini, F. Veglia, E. Tremoli Source Type: research

ProSalute: A new community program for cardiovascular health
The largest benefit of Community programs for cardiovascular health may be obtained by addressing high-risk, disadvantaged and traditionally hard-to-reach groups. Effective actions include health promotion, timely screening of modifiable risk factors, application of evidence-based targets and interventions, broad access to heart-friendly environments/facilities and dissemination of favorable social norms. Thus, community prevention is a multifaceted task that requires multidisciplinary collaboration. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: J.P. Werba, M. Giroli, N. Simonelli, L. Vigo, M. Amato, A. Gorini, F. Veglia, E. Tremoli Source Type: research

Health system barriers and facilitators to medication adherence for the secondary prevention of cardiovascular disease: A systematic review
Background: Secondary prevention of cardiovascular disease (CVD) is cost-effective, but uptake is suboptimal. Understanding barriers and facilitators to adherence to secondary prevention of CVD at multiple health system levels may inform policy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: J.P. Werba, S. Khandelwal, L. Nambiar, M. Saxena, V. Peck, M. Moniruzzaman, J. Rocha Faria Neto, K. Curi Quinto, D. Leong, A. Banerjee Source Type: research

Role of Sphingosine 1-phosphate (S1P) and its receptor S1P3 in the reverse cholesterol transport
Sphingosine 1-phosphate (S1P) exerts multiple functions in the cardiovascular system with potential impact on atheroprotection. However, molecular mechanisms accounting for this effect are still under-investigated. The aim of the present study is to demonstrate that the antiatherogenic activity of S1P is associated, at least in part, to the modulation of lipid metabolism. Core tool of this work is the mouse model modified to amplify S1P signaling over the receptor S1P3 in macrophages (S1P3-Lyz mice). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: I. Zanotti, D. Greco, S. Battista, L.B. Giva, M.P. Adorni, G.D. Norata, M. Simoni, F. Bernini, J.R. Nofer, F. Pot ì Source Type: research

Case report: Evolocumab in association with lipoprotein apheresis improves lipid profile in a 49-years old woman with familial hypercholesterolemia and statin intolerance
A 49-years old woman, affected by HeFH, (mutation on LDLR gene: c.1646G>A exon 11; p.Gly528 Asp – aminoacid change) and statin intolerance characterized by myositis and rhabdomyolysis (in 2010 after initiation of atorvastatin), was admitted to the outpatient Lipid Clinic of Verona. She was also affected by Cogan's Syndrome and ostheoporosis. Hypercholesterolemia was diagnosed in her adolesce nce, and, in the absence of specific lipid lowering therapy, the plasma lipid levels were: total cholesterol=522 mg/dL, LDL-C=434 mg/dL, HDL-C=84 mg/dL, triglycerides=120 mg/dL, Lp(a)=11 mg/dL. (Source: Nutrition, Metabolism, ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: M.G. Zenti, A. Altomari, V. Sanga, G. Ceradini, A. Fabris, A. Lupo, M. Dauriz, E. Bonora Source Type: research

The 30th National Congress of the Societ à Italiana per lo Studio dell'Arteriosclerosi
The 30th National Congress of the Societ à Italiana per lo Studio dell'Arteriosclerosi was held in Rome on November 20–22 2016, gathering numerous physician and researchers that operate in the field of cardiovascular prevention across the national territory. In this way, as is customary, the Congress mixed both clinical and basic resear ch focusing on many themes of current interest in the scientific society and, therefore, represented a success with regards to their scientific degree. New advancements in different fields were discussed, by integrating physio-pathological and genetic aspects with translational...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Tags: Conference Report Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Source Type: research

In Memoriam: Professor Giuseppe Schillaci
The premature departure of Prof. Giuseppe Schillaci on December 21st 2016 at the age of 55 years was a tremendous shock for science in both the national and international communities. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Tags: Obituary Source Type: research

Serum uric acid is not independently associated with plasma renin activity and plasma aldosterone in hypertensive adults
In experimental investigations conducted in rats, raising serum uric acid (SUA) levels resulted in stimulation of intrarenal renin expression. Studies in humans exploring the association of SUA with plasma renin activity (PRA) yielded conflicting results. Moreover, little is known about the relationship of SUA with plasma aldosterone concentration (PAC). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 27, 2016 Category: Nutrition Authors: Giuseppe Mul è, Antonella Castiglia, Massimiliano Morreale, Giulio Geraci, Claudia Cusumano, Laura Guarino, Dario Altieri, Marcella Panzica, Francesco Vaccaro, Santina Cottone Source Type: research

Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions
Critically discuss the available data, to identify the current gaps and to provide key concepts that will help clinicians in translating the biology of adipokines in the context of atherosclerosis and cardio-metabolic diseases. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 23, 2016 Category: Nutrition Authors: M. Ruscica, A. Baragetti, A.L. Catapano, G.D. Norata Tags: Review Source Type: research

Comparison of two surrogate estimates of insulin resistance to predict cardiovascular disease in apparently healthy Individuals
Insulin resistance is associated with a cluster of abnormalities that increase cardiovascular disease (CVD). Several indices have been proposed to identify individuals who are insulin resistant, and thereby at increased CVD risk. The aim of this study was to compare the abilities of 3 indices to accomplish that goal: 1) plasma triglyceride x glucose index (TGxG); 2) plasma triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C); and 3) Metabolic Syndrome (MetS). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 23, 2016 Category: Nutrition Authors: Martin R. Salazar, Horacio A. Carbajal, Walter G. Espeche, Marcelo Aizpur úa, Carlos A. Dulbecco, Gerald M. Reaven Source Type: research

Translating adipokines biology in atherosclerosis and cardiovascular diseases: gaps and open questions
Adipose tissue is nowadays recognized as an active endocrine organ, a function related to the ability to secrete adipokines (such as leptin and adiponectin) and pro-inflammatory cytokines (tumor necrosis factor alpha and resistin). Studies in vitro and in animal models have observed that obesity status presents a chronic low-grade inflammation as the consequence of the of immune cells infiltrating the adipose tissue as well as adipocytes. This inflammatory signature is often related to the presence of cardiovascular diseases, including atherosclerosis and thrombosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 23, 2016 Category: Nutrition Authors: Massimiliano Ruscica, Andrea Baragetti, Alberico Luigi Catapano, Giuseppe Danilo Norata Source Type: research

New risk and protective factors for severe hypoglycaemia in people with type 1 diabetes
o evaluate risk factors for severe hypoglycaemia (SH) in patients with Type 1 diabetes (T1DM). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 23, 2016 Category: Nutrition Authors: T. Wohland, J.D. Holstein, O.M. Patzer, M. Mende, T. Tiemann, C. Koch-Tessarek, P. Kovacs, A. Holstein Source Type: research

Life course path analysis of total and central adiposity throughout adolescence on adult blood pressure and insulin resistance
We aimed to study whether the effect of adolescent adiposity on adult blood pressure and insulin resistance was mediated by adult adiposity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 23, 2016 Category: Nutrition Authors: J. Ara újo, M. Severo, S. Santos, E. Ramos Source Type: research

Baseline metabolic disturbances and the twenty-five year risk of incident cancer in a Mediterranean population: Methodological issues
We read with great interest the paper authored by Noto et  al. published in Nutrition, Metabolism& Cardiovascular Diseases in 2016 [1]. The authors aimed to assess the risk of incident cancer associated with obesity and metabolic disturbances in a Mediterranean population. They concluded that metabolic disturbances are predictive of cancer after a 25-year follow-up of a Mediterranean population following a traditional Mediterranean diet. Although this valuable study has been conducted, some methodological issues should be considered to avoid misinterpretations. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 17, 2016 Category: Nutrition Authors: N. Karamzad, E. Ayubi, S. Safiri Tags: Letter to the Editor Source Type: research

Baseline metabolic disturbances and the twenty-five years risk of incident cancer in a Mediterranean population: Methodological issues
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 17, 2016 Category: Nutrition Authors: Nahid Karamzad, Erfan Ayubi, Saeid Safiri Tags: Letter to the Editor Source Type: research

Salba-chia (Salvia hispanica l.) in the treatment of overweight and obese patients with type 2 diabetes: a double-blind randomized controlled trial
Preliminary findings indicate that consumption of Salba-chia (Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 8, 2016 Category: Nutrition Authors: V. Vuksan, A.L. Jenkins, C. Brissette, L. Choleva, E. Jovanovski, A.L. Gibbs, R.P. Bazinet, F. Au-Yeung, A. Zurbau, H.V.T. Ho, L. Duvnjak, J.L. Sievenpiper, R.G. Josse, A. Hanna Source Type: research

Risk of all-cause mortality in abdominal obesity phenotypes: Tehran Lipid and Glucose Study
In this study we assessed the risk of all-cause mortality in dif ferent abdominal obesity phenotypes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 5, 2016 Category: Nutrition Authors: Soraya Doustmohamadian, Sara Serahati, Maryam Barzin, Sorena Keihani, Fereidoun Azizi, Farhad Hosseinpanah Source Type: research

Exposure to famine in early life and the risk of obesity in adulthood in Qingdao: evidence from the 1959-1961 Chinese Famine
We aimed to evaluate the association between famine exposure during early life and obesity and obesitymax(obese at the highest weight) in adulthood. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 5, 2016 Category: Nutrition Authors: L. Liu, Z.C. Pang, J.P. Sun, B. Xue, S.J. Wang, F. Ning, Q. Qiao Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 29, 2016 Category: Nutrition Source Type: research

Contribution of fibroblast growth factor 23 to Framingham Risk Score for identifying subclinical atherosclerosis in Chinese men
Fibroblast growth factor 23 (FGF23) was demonstrated to be involved in the occurrence and development of cardiovascular disease (CVD). The goal of the present study was to investigate the relationship between serum FGF23 levels and the carotid intima-media thickness (C-IMT) in men with a low-to-moderate CVD risk. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 23, 2016 Category: Nutrition Authors: Xiang Hu, Xiaojing Ma, Yuqi Luo, Yiting Xu, Qin Xiong, Xiaoping Pan, Yuqian Bao, Weiping Jia Source Type: research

Real-world effectiveness and safety of dapagliflozin therapy added to a GLP1 receptor agonist in patients with type 2 diabetes
To evaluate the effectiveness and safety of a sodium –glucose cotransporter-2 (SGLT-2) inhibitor, dapagliflozin, in patients with type 2 diabetes mellitus (T2DM) and background glucagon-like peptide-1 receptor agonist (GLP1-RA) therapy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: J.J. Gorgojo-Mart ínez, C. Serrano-Moreno, A. Sanz-Velasco, G. Feo-Ortega, F. Almodóvar-Ruiz Source Type: research

Cpt1a Methylation is Associated with Plasma Adiponectin
Adiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health. Despite clinical relevance and high heritability, the determinants of plasma adiponectin levels remain poorly understood. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: S. Aslibekyan, A.N. Do, H. Xu, S. Li, M.R. Irvin, D. Zhi, H.K. Tiwari, D.M. Absher, A.R. Shuldiner, T. Zhang, W. Chen, K. Tanner, C. Hong, B.D. Mitchell, G. Berenson, D.K. Arnett Source Type: research

Active vitamin d treatment in ckd patients raises serum sclerostin and this effect is modified by circulating pentosidine levels
1,25(OH)2Vitamin D increases the expression of sclerostin gene. Whether vitamin D receptor activation (VDRA) influences serum sclerostin in CKD and whether compounds interfering with VDRA like Advanced Glycosylation End Products (AGEs) may alter the sclerostin response to VDRA is unknown. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: C. Torino, P. Pizzini, S. Cutrupi, G. Tripepi, F. Mallamaci, R. Thadhani, C. Zoccali Source Type: research

GALNT2 Effect on HDL-Cholesterol and Triglycerides Levels in Humans: Evidence of Pleiotropy?
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: R. Di Paola, A. Marucci, V. Trischitta Source Type: research

Real-world effectiveness and safety of dapagliflozin therapy added to a GLP-1 receptor agonist in patients with type 2 diabetes
To evaluate the effectiveness and safety of a sodium-glucose co-transporter-2 (SGLT-2) inhibitor, dapagliflozin, in patients with T2DM and background GLP-1 receptor agonist (GLP1-RA) therapy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: J.J. Gorgojo-Mart ínez, C. Serrano-Moreno, A. Sanz-Velasco, G. Feo-Ortega, F. Almodóvar-Ruiz Source Type: research

Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance
Epicatechin (EC) intake has been suggested to be beneficial for the prevention of cardiovascular disorders, and it is well known that adipose tissue inflammation is one of the major risk factors for coronary heart diseases. The purpose of the present study was to determine the in vitro and in vivo effects of EC on adipose tissue inflammation and obesity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: Tomomi Sano, Shintaro Nagayasu, Shigeki Suzuki, Misaki Iwashita, Akiko Yamashita, Takanori Shinjo, Terukazu Sanui, Akifumi Kushiyama, Takashi Kanematsu, Tomoichiro Asano, Fusanori Nishimura Source Type: research

Joint Position Statement on “Nutraceuticals for the treatment of hypercholesterolemia” of the Italian Society of Diabetology (SID) and of the Italian Society for the Study of Arteriosclerosis (SISA)
Hypercholesterolemia is a major risk factor for cardiovascular morbidity and mortality. There is a large body of evidence showing that low-density lipoprotein (LDL) cholesterol-lowering is associated with a significant cardiovascular risk reduction, both in primary and secondary prevention.Treatment strategies to achieve optimal LDL cholesterol levels include both interventions on lifestyle and pharmacological measures. The initial therapeutic approach to patients with hypercholesterolemia includes a low dietary intake of cholesterol, saturated and "trans" fats and an increase in dietary fiber, associated with ph...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 22, 2016 Category: Nutrition Authors: Matteo Pirro, Claudia Vetrani, Cristina Bianchi, Massimo R. Mannarino, Franco Bernini, Angela A. Rivellese Tags: Review Source Type: research

Dietary Glycemic index, Glycemic load and metabolic profile in children with Phenylketonuria
No data exist in the current literature on the glycemic index (GI) and glycemic load (GL) of the diet of phenylketonuric (PKU) children. The aims of this study were to examine the dietary GI and GL in PKU children on a low-phenylalanine (Phe)-diet and to evaluate whether an association may exist between the carbohydrate quality and the metabolic profile. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 21, 2016 Category: Nutrition Authors: F. Moretti, N. Pellegrini, E. Salvatici, V. Rovelli, G. Banderali, G. Radaelli, F. Scazzina, M. Giovannini, E. Verduci Source Type: research

Influence of the degree of adherence to the Mediterranean diet on  the cardiometabolic risk in peri and menopausal women. The Flamenco project
The Mediterranean diet (MD) has been associated with reduced morbidity from cardiovascular diseases in the general population. The aim of this study was to assess whether different degrees of adherence to the MD were associated with the cardiometabolic risk in peri and menopausal women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 19, 2016 Category: Nutrition Authors: P. Ruiz-Cabello, I. Coll-Risco, P. Acosta-Manzano, M. Borges-Cosic, F.J. Gallo-Vallejo, P. Aranda, M. L ópez-Jurado, V.A. Aparicio Source Type: research

Epicardial adipose tissue is related to cardiac function in elderly women, but not in men
Epicardial adipose tissue (EAT) is easily quantifiable visceral adipose tissue that is closely associated with cardiometabolic disease including heart failure with preserved left ventricular (LV) ejection fraction. As body fat distribution and metabolism are different between men and women, we evaluated the sex difference in EAT thickness and its relationship to cardiac function. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 19, 2016 Category: Nutrition Authors: Su A. Kim, Mi-Na Kim, Wan Joo Shim, Seong-Mi Park Source Type: research

Influence of the degree of adherence to the Mediterranean diet on the cardiometabolic risk in peri and menopausal women. The Flamenco Project
The Mediterranean diet (MD) has been associated with reduced morbidity from cardiovascular diseases in general population. The aim of this study was to assess whether different degrees of adherence to the MD were associated with the cardiometabolic risk in peri and menopausal women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 19, 2016 Category: Nutrition Authors: P. Ruiz-Cabello, I. Coll-Risco, P. Acosta-Manzano, M. Borges-Cosic, F.J. Gallo-Vallejo, P. Aranda, M. L ópez-Jurado, V.A. Aparicio Source Type: research

8-hydroxy-2-deoxyguanosine levels and heart failure: a systematic review and meta-analysis of the literature
The generation of reactive oxygen species (ROS) play an important role in the etiology of several pathological conditions. High levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of oxidative damage of DNA, have been found in patients with heart failure (HF). We performed a meta-analysis of literature to investigate the association between 8-OHdG levels and HF. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 19, 2016 Category: Nutrition Authors: Alessandro Di Minno, Linda Turnu, Benedetta Porro, Isabella Squellerio, Viviana Cavalca, Elena Tremoli, Matteo Nicola Dario Di Minno Source Type: research

Healthcare resource use, direct and indirect costs of hypoglycemia in type 1 and type 2 diabetes, and nationwide projections. Results of the Hypos-1 study
To obtain an accurate picture of the total costs of hypoglycemia, including the indirect costs and comparing the differences between type 1 (T1DM) and type 2 diabetes mellitus (T2DM) (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 18, 2016 Category: Nutrition Authors: C.B. Giorda, M.C. Rossi, O. Ozzello, S. Gentile, A. Aglialoro, A. Chiambretti, F. Baccetti, F.M. Gentile, F. Romeo, G. Lucisano, A. Nicolucci, HYPOS-1 Study Group of AMD Source Type: research

Self-Initiated Changes in Physical Activity Levels Improve Cardiometabolic Profiles: A Longitudinal Follow-Up Study
While studies have described the importance of higher physical activity levels (PAL) in weight loss, the impact of self-initiated PAL on health status warrants further study. We aimed to prospectively examine the effects of self-initiated longitudinal PAL changes on body mass index (BMI) and cardiometabolic parameters in normal weight, overweight and obese adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 8, 2016 Category: Nutrition Authors: Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato, Wagner Luiz do Prado, Raquel D.O. Concei ção, Raul D. Santos, Márcio Sommer Bittencourt Source Type: research

Cardiovascular complications and drug prescriptions in subjects with and without diabetes in a Northern region of Italy, in 2002 and 2012
We describe the incidence of major CV events, deaths and drug prescribing patterns from 2002 to 2012 in subjects with (DM) or without diabetes mellitus (No DM). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 24, 2016 Category: Nutrition Authors: M. Baviera, F. Avanzini, I. Marzona, M. Tettamanti, T. Vannini, L. Cortesi, I. Fortino, A. Bortolotti, L. Merlino, R. Trevisan, M.C. Roncaglioni Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 22, 2016 Category: Nutrition Source Type: research

Increment of Serum Bilirubin as an Independent Marker Predicting New-onset Type 2 Diabetes Mellitus in a Korean Population
Several cross-sectional studies reported that serum bilirubin concentrations had an inverse association with type 2 diabetes mellitus (T2DM) prevalence. The aim of the current study was to investigate the relationship between percentage change in bilirubin levels (PCB) and incident risk of T2DM using a longitudinal model. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 22, 2016 Category: Nutrition Authors: S.-E. Lee, J.H. Kim, Y.-B. Lee, J.E. Jun, S.-M. Jin, J.H. Jee, J.C. Bae Source Type: research

Sex differences in the impact of nonalcoholic fatty liver disease on cardiovascular risk factors
We examined whether men exhibit greater differences in established CVD risk factors between NAFLD and non-NAFLD than women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 19, 2016 Category: Nutrition Authors: Tingting Du, Xingxing Sun, Gang Yuan, Xinrong Zhou, Huimin Lu, Xuan Lin, Xuefeng Yu Source Type: research

Maternal plasma polyunsaturated fatty acid levels during pregnancy and childhood lipid and insulin levels
We examined the associations of maternal plasma n-3 and n-6 PUFA levels during pregnancy with childhood lipid and insulin levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2016 Category: Nutrition Authors: A.J. Vidakovic, V.W.V. Jaddoe, T. Voortman, H. Demmelmair, B. Koletzko, R. Gaillard Source Type: research

Maternal plasma polyunsaturated fatty acid levels during pregnancy and childhood lipids and insulin levels
We examined the associations of maternal plasma n-3 and n-6 PUFA levels during pregnancy with childhood lipids and insulin levels. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2016 Category: Nutrition Authors: Aleksandra Jelena Vidakovic, Vincent WV. Jaddoe, Trudy Voortman, Hans Demmelmair, Berthold Koletzko, Romy Gaillard Source Type: research

Total HDL cholesterol efflux capacity in healthy children – associations with adiposity and dietary intakes of mother and child
High-density lipoprotein (HDL) cholesterol efflux capacity in adults may be a measure of the atheroprotective property of HDL. Little however, is known about HDL cholesterol efflux capacity in childhood. We aimed to investigate the relationship between HDL cholesterol efflux capacity and childhood anthropometrics in a longitudinal study (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2016 Category: Nutrition Authors: Hala Khalil, Celine Murrin, Marcella O'Reilly, Karien Viljoen, Ricardo Segurado, John O ’Brien, Rebecca Somerville, Fiona McGillicuddy, Cecily C. Kelleher Source Type: research