Phenotypes and concentration of PON1 in cardiovascular disease: the role of nutrient intake
Paraoxonase 1 (PON1) is considered to play a crucial role as an anti-atherosclerotic factor. The PON1 activity is affected by genetic polymorphisms, environmental factors, age, sex, lifestyle, pharmaceutical drugs, and dietary factors. The aim of this study was to evaluate the association between macro- and micronutrients as well as PON1 concentration and activities in patients with cardiovascular diseases (CVD), cardiovascular risk factors but no CVD (CRF), and in healthy controls (control group). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 10, 2019 Category: Nutrition Authors: N. Ponce-Ruiz, F.E. Murillo-Gonz ález, A.E. Rojas-García, Y.Y. Bernal-Hernández, Mike Mackness, J. Ponce-Gallegos, B.S. Barrón-Vivanco, I. Hernández-Ochoa, C.A. González-Arias, L. Ortega-Cervantes, G. Cardoso-Saldaña, I.M. Medina-Díaz Source Type: research

Serum 25-hydroxyvitamin-D and nonalcoholic fatty liver disease: Does race/ethnicity matter? Findings from the MESA Cohort
Low serum 25-hydroxyvitamin D (25(OH)D) is associated with higher nonalcoholic fatty liver disease (NAFLD) risk in studies of mainly white participants. Significant racial/ethnic differences exist in serum 25(OH)D and NAFLD prevalence questioning extending this association to other racial/ethnic groups. We tested whether the association between serum 25(OH)D and NAFLD vary by race/ethnicity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 10, 2019 Category: Nutrition Authors: Samar.R. El Khoudary, Saad Samargandy, Irfan Zeb, Temitope Foster, Ian H. de Boer, Dong Li, Matthew J. Budoff Source Type: research

Does a rise in plasma erythropoietin after high-altitude exposure  affect FGF23 in healthy volunteers on a normal or low-phosphorus diet?
Data of experimental rodent models suggest that hypoxia with subsequent increase in erythropoietin stimulates the expression of the phosphaturic hormone fibroblast growth factor 23 (FGF23). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Insa E. Emrich, Juliane Dederer, Angelika Kircher, Verena Klemis, Claudia S. Lennartz, Kathrin Untersteller, Stefan Wagenpfeil, Danilo Fliser, Myles Wolf, Gunnar H. Heine Source Type: research

Carbohydrate intake and risk of metabolic syndrome: A dose –response meta-analysis of observational studies
Epidemiological association studies have reported inconsistent findings on the relationship between carbohydrate intake and risk of metabolic syndrome (MetS). Therefore, we aimed to conduct the first dose –response meta-analysis to investigate this effect. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Ya-Shu Liu, Qi-Jun Wu, Yang Xia, Jia-Yu Zhang, Yu-Ting Jiang, Qing Chang, Yu-Hong Zhao Tags: Systematic Reviews and Meta-analyses Source Type: research

Diabetes Diagnosis from Administrative Claims and Estimation of the True Prevalence of Diabetes among 4.2 Million Individuals of the Veneto Region (North East Italy)
Diabetes can often remain undiagnosed or unregistered in administrative databases long after its onset, even when laboratory test results meet diagnostic criteria. In the present work, we analyse healthcare data of the Veneto Region, North East Italy, with the aims of: (i) developing an algorithm for the identification of diabetes from administrative claims (4,236,007 citizens), (ii) assessing its reliability by comparing its performance with the gold standard clinical diagnosis from a clinical database (7,525 patients), (iii) combining the algorithm and the laboratory data of the regional Health Information Exchange (rHIE...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Claudio Saccavini, Angelo Avogaro, Gian Paolo Fadini Source Type: research

Osteoprotegerin in diabetic osteopathy
The aim of this study is to evaluate the relationship between OPG and the degree of glycaemic control in a population of elderly subjects. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Alessia Valentini, Maria Assunta Cianfarani, Massimo Federici, Umberto Tarantino, Aldo Bertoli Tags: Review Source Type: research

Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice
Cardiovascular diseases are the main cause of mortality in obesity. Despite advanced understanding, the mechanisms that regulate cardiac progenitor cells (CPC) survival in pathological conditions are not clear. Low IGF-1 plasma levels are correlated to obesity, cardiomyopathy and CPC death, so this work aimed to investigate IGF-1 therapeutic potential on cardiomyopathy and its relationship with the survival, proliferation and differentiation of CPC in Western diet-induced obesity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Daniela Andrade, Genilza Oliveira, Luciana Menezes, Ana L úcia Nascimento, Simone Carvalho, Ana Carolina Stumbo, Alessandra Thole, Érica Garcia-Souza, Anibal Moura, Laís Carvalho, Erika Cortez Source Type: research

Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on normal or low phosphorus diet?
Experimental rodent models suggest that hypoxia with subsequent increase in erythropoietin stimulates the expression of the phosphaturic hormone fibroblast growth factor 23 (FGF23). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: I.E. Emrich, J. Dederer, A. Kircher, V. Klemis, C.S. Lennartz, K. Untersteller, S. Wagenpfeil, D. Fliser, M. Wolf, G.H. Heine Source Type: research

Carbohydrate intake and risk of metabolic syndrome: a dose-response meta-analysis from observational studies
Epidemiological association studies have shown inconsistent findings between carbohydrate intake and risk of metabolic syndrome (MetS). Therefore, we aim to conduct the first dose-response meta-analysis to investigate this effect. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 9, 2019 Category: Nutrition Authors: Ya-Shu Liu, Qi-Jun Wu, Yang Xia, Jia-Yu Zhang, Yu-Ting Jiang, Qing Chang, Yu-Hong Zhao Tags: Systematic Reviews and Meta-analyses Source Type: research

The Association of Dietary Patterns and Carotid Intima-Media Thickness: A Synthesis of Current Evidence
This study systematically explores the association of a posteriori and a priori DPs and CIMT. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 3, 2019 Category: Nutrition Authors: S. Bhat, G. Mocciaro, S. Ray Tags: Systematic Reviews and Meta-analyses Source Type: research

Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
To evaluate the biomarkers related to cardiovascular risk in pre-pubertal preterm children with a birth weight of less than 1,500g and relate them to current nutritional status, insulin resistance, and inflammation. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 31, 2019 Category: Nutrition Authors: D.O. Schoeps, S. Holzer, F.I.M.D. Suano-Souza, S. Hix, F.L.A. Fonseca, R.O.S. Sarni Source Type: research

Circulating glutamate level as a potential biomarker for abdominal obesity and metabolic risk
Circulating level of glutamate, a by-product of the catabolism of branched-chain amino acids, has been positively correlated with visceral adipose tissue accumulation and waist circumference (WC). The aim of the present study was to assess the potential of using glutamate level to identify individuals with abdominal obesity and a high cardiometabolic risk. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 31, 2019 Category: Nutrition Authors: I. Maltais-Payette, B. Allam-Ndoul, L. P érusse, M.-C. Vohl, A. Tchernof Source Type: research

Physical Activity Intervention Improved The Number And Functionality Of Endothelial Progenitor Cells In Low Birth Weight Children
The purpose of this study was to investigate whether an intervention with physical activity (PA) would promote positive effects on the angiogenic factors, mobilization, and functionality of circulating endothelial progenitor cells (EPCs) in children with low birth weight (LBW). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 30, 2019 Category: Nutrition Authors: Livia V. Souza, Franciele De Meneck, Tiago Fernandes, Edilamar M. Oliveira, Maria do Carmo Franco Source Type: research

Postnatal delayed growth impacts cognition but rescues programmed impaired pulmonary vascular development in an IUGR rat model
Intrauterine growth restriction (IUGR) is a state of slower fetal growth usually followed by a catch-up growth. Postnatal catch-up growth in IUGR models increases the incidence of pulmonary arterial hypertension in adulthood. Here, we hypothesize that the adverse pulmonary vascular consequences of IUGR may be improved by slowing down postnatal growth velocity. Meanwhile, cognitive function was also studied. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 30, 2019 Category: Nutrition Authors: LingLing Yan, Yu Wang, ZiMing Zhang, ShanShan Xu, Rahim Ullah, XiaoFei Luo, XueFeng Xu, XiaoLu Ma, Zheng Chen, LiYan Zhang, Ying Lv, LiZhong Du Source Type: research

Factors associated with longitudinal changes in serum concentrations of Mac-2 binding protein: a prospective 3-year observational study
Mac-2 binding protein (M2BP) plays an important role in cell adhesion. In a recent cross-sectional study we reported that serum M2BP concentrations may reflect silent atherosclerosis. The aim of the present prospective follow-up study was to investigate possible relationships between changes in concentrations of M2BP and other factors over a>3-year period. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 24, 2019 Category: Nutrition Authors: Tomonori Sugiura, Yasuaki Dohi, Hiroyuki Takase, Sumiyo Yamashita, Yuji Tsuzuki, Shintaro Ogawa, Yasuhito Tanaka, Nobuyuki Ohte Source Type: research

Associations of a Metabolic Syndrome Severity Score with Coronary Heart Disease and Diabetes in Fasting vs. Non-fasting Individuals
Many traditional assessments of risk for coronary heart disease (CHD) and diabetes require laboratory studies performed after an 8-hour fast. We assessed whether metabolic-syndrome (MetS) severity would remain linked to future CHD and diabetes even when assessed from non-fasting samples. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 24, 2019 Category: Nutrition Authors: Mark D. DeBoer, Stephanie L. Filipp, Matthew J. Gurka Source Type: research

Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors
The aim of this study was to investigate possible associations among markers of mineralization, plaque instability and the main risk factors of atherosclerosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 23, 2019 Category: Nutrition Authors: Manuel Scimeca, Lucia Anemona, Annarita Granaglia, Rita Bonfiglio, Nicoletta Urbano, Nicola Toschi, Giuseppe Santeusanio, Stefania Schiaroli, Silvestro Mauriello, Virginia Tancredi, Orazio Schillaci, Elena Bonanno, Alessandro Mauriello Source Type: research

Systemic lupus erythematosus is associated with poor outcome after acute myocardial infarction
Systemic lupus erythematosus (SLE) is associated with a higher risk of cardiovascular disease. However, whether or not SLE is associated with poor outcomes after acute myocardial infarction (AMI) is not clear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 20, 2019 Category: Nutrition Authors: Shin-Rong Ke, Cheng-Wei Liu, Yen-Wen Wu, K. Robert Lai, Chiung-Yi Wu, Jeng-Wei Lin, Chien-Lung Chan, Ren-Hao Pan Source Type: research

Effect of vitamin D supplementation on endothelial function – an updated systematic review with meta-analysis and meta-regression
Atherogenesis and endothelial dysfunction contribute to cardiovascular risk and vitamin D has been implemented in endothelial repair. This systematic review, meta-analysis and meta-regression aims to establish the effect of vitamin D supplementation on endothelial function. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 19, 2019 Category: Nutrition Authors: Nick L. Pincombe, Melissa J. Pearson, Neil A. Smart, Nicola King, Gudrun Dieberg Tags: Systematic Reviews and Meta-analyses Source Type: research

Validation of the echocardiographic assessment of epicardial adipose tissue thickness at the Rindfleisch fold for the prediction of coronary artery disease
Echocardiography is a promising technique for the assessment of epicardial adipose tissue (EAT). Increased EAT thickness is associated with different cardiac diseases, including; coronary artery disease (CAD). Since several different echocardiographic approaches have beenproposed to measure EAT, the identification of a standardized method is needed. We propose the assessment of EAT maximal thickness at the Rindfleisch fold, the reproducibility of this measurement and its correlation with EAT thickness and volume assessed at cardiac magnetic resonance (CMR). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 19, 2019 Category: Nutrition Authors: Valentina Parisi, Laura Petraglia, Roberto Formisano, Aurelio Caruso, Maria Gabriella Grimaldi, Dario Bruzzese, Fabrizio Vincenzo Grieco, Maddalena Conte, Stefania Paolillo, Alessandra Scatteia, Santo Dellegrottaglie, Annarita Iavazzo, Pasquale Campana, E Source Type: research

Adherence to Mediterranean Diet and Prognosis in Older Patients Scheduled to Undergo Cardiac Resynchronization Therapy
Adherence to the Mediterranean diet (MedDiet) has been associated with prolonged survival in older individuals. However, it is unknown whether adherence to MedDiet is associated with the prognosis in older patients scheduled to undergo cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the association between adherence to the MedDiet and clinical outcomes at 12 months follow-up after CRT implantation in older patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 14, 2019 Category: Nutrition Authors: Alberto Dominguez-Rodriguez, Pablo Avanzas, Pedro Abreu-Gonzalez, Nestor Baez-Ferrer, Francisco Javier Mart ín-Sanchez, Óscar Mirò Source Type: research

The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats
This study was designed to assess the effects of probiotic Lactobacillus (L.) fermentum 296, a fruit-derived bacteria strain, against cardiometabolic disorders induced by HF diet. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 14, 2019 Category: Nutrition Authors: Raissa Georgianna Silva Cavalcante, Thatyane Mariano Rodrigues de Albuquerque, Micaelle Oliveira de Luna Freire, Georgianna de Ara újo Henriques Ferreira, Lucas Alves Carneiro dos Santos, Marciane Magnani, Josiane Campos Cruz, Valdir de Andrade Braga, Ev Source Type: research

High Fat Diet downregulates regulatory T cells in the myocardium of Spontaneous Hypertensive Rats
Regulatory T cells (Tregs) play an important role in cardiovascular complications with the immune response. However, the role of Tregs in high fat diet (HFD)-induced myocardial fibrosis has not been fully elucidated to date. Therefore, we investigated whether HFD suppresses Tregs activation in the myocardium of spontaneously hypertensive rats (SHRs), which aggregates myocardial fibrosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 14, 2019 Category: Nutrition Authors: S.K. Hong, E.H. Choo, S.H. Ihm, K.Y. Chang Tags: Short Communication Source Type: research

Insulin resistance, but not insulin response, during oral glucose tolerance test (OGTT) is associated to worse histological outcome in obese NAFLD
Obese subjects are at high risk of nonalcoholic fatty liver disease (NAFLD) and diabetes (T2D) due to insulin resistance (IR). Since high glucose levels are as toxic as lipids for hepatic metabolism, we hypothesize that altered response to oral glucose tolerance test (OGTT) is associated to more severe NAFLD with significant/advanced liver damage. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 10, 2019 Category: Nutrition Authors: Federica Coccia, Moira Testa, Gloria Guarisco, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Amalia Gastaldelli, Danila Capoccia Source Type: research

Interrelationships among common predictors of cardiovascular diseases in patients of OSA: A large-scale observational study
The apolipoprotein B/apolipoprotein A-I (ApoB/ApoA-I) and insulin resistance has been recognized as common cardiovascular diseases (CVD) risk factors. However, whether they were biomarkers for 10-year CVD risk in obstructive sleep apnea (OSA) had been rarely studied. Besides, interrelationships between the ApoB/ApoA-I, insulin resistance and OSA remain unclear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 9, 2019 Category: Nutrition Authors: Xinyi Li, Fan Wang, Huajun Xu, Yingjun Qian, Jianyin Zou, Mingpo Yang, Huaming Zhu, Hongliang Yi, Jian Guan, Shankai Yin Source Type: research

Interrelationships among common predictors of cardiovascular diseases in patients of OSA:a large-scale observational study
The apolipoprotein B/apolipoprotein A-I (ApoB/ApoA-I) and insulin resistance has been recognized as common cardiovascular diseases (CVD) risk factors. However, whether they were biomarkers for 10-year CVD risk in obstructive sleep apnea (OSA) had been rarely studied. Besides, interrelationships between the ApoB/ApoA-I, insulin resistance and OSA remain unclear. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 9, 2019 Category: Nutrition Authors: Xinyi Li, Fan Wang, Huajun Xu, Yingjun Qian, Jianyin Zou, Mingpo Yang, Huaming Zhu, Hongliang Yi, Jian Guan, Shankai Yin Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 7, 2019 Category: Nutrition Source Type: research

Exploring the heterogeneity of the effects of SGLT-2 inhibitors in cardiovascular outcome trials
– The interpretation of discrepancies across cardiovascular safety trials (CVOT) with SGLT-2 inhibitors in the incidence of major cardiovascular events (MACE) and mortality is complex, because of heterogeneity in trial protocols and baseline characteristics of patients enrolled. Aim of this analys is is the exploration of possible determinants of heterogeneity of relative risk reduction for major cardiovascular events (MACE) and all-cause mortality. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 5, 2019 Category: Nutrition Authors: Edoardo Mannucci, Ilaria Dicembrini, Besmir Nreu, Matteo Monami Source Type: research

Antiatherogenic properties of high-density lipoproteins from arterial plasma are attenuated as compared to their counterparts of venous origin
High-density lipoprotein (HDL) particles play atheroprotective roles by their ability to efflux cholesterol from foam cells and to protect low-density lipoproteins (LDLs) from oxidative damage in the arterial intima. We hypothesized that antioxidative properties of HDLs can be attenuated in the oxygen-rich prooxidative arterial environment, contributing to the development of atherosclerosis. To evaluate this hypothesis, we compared antioxidative activity of HDLs from arterial and venous plasmas. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 3, 2019 Category: Nutrition Authors: D. Bonnefont-Rousselot, L. Benouda, R. Bittar, M. Darabi-Amin, P. Demondion, P. Lesnik, P. Leprince, A. Kontush, J.-C. Charniot, P. Giral Source Type: research

Common bean protein hydrolysate modulates lipid metabolism and  prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet
Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 31, 2019 Category: Nutrition Authors: Mariana J.C. Gomes, S âmara L.S. Lima, Natália E.G. Alves, Andressa Assis, Maria E.C. Moreira, Renata C.L. Toledo, Carla O.B. Rosa, Olívia R. Teixeira, Priscila Z. Bassinello, Elvira G. De Mejía, Hércia S.D. Martino Source Type: research

Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet
Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks. Male adult mice were divided into three experimental groups (n = 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 31, 2019 Category: Nutrition Authors: Mariana J.C. Gomes, S âmara L.S. Lima, Natália E.G. Alves, Andressa Assis, Maria E.C. Moreira, Renata C.L. Toledo, Carla O.B. Rosa, Olívia R. Teixeira, Priscila Z. Bassinello, Elvira G. De Mejía, Hércia S.D. Martino Source Type: research

Alcohol Consumption and Subclinical Atherosclerosis among South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study
South Asians are the second fastest growing ethnic group in the United States, and they have a high risk for cardiovascular disease (CVD). Moderate alcohol consumption has been associated with lower CVD risk in some race/ethnic groups, but the association of alcohol consumption and atherosclerosis in South Asians has not been investigated. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 31, 2019 Category: Nutrition Authors: Parag A. Chevli, Amer I. Aladin, Alka M. Kanaya, Namratha R. Kandula, Diego Malaver, David M. Herrington Source Type: research

Impact of phytosterol supplementation on plasma lipoprotein(a) and free fatty acid (FFA) concentrations: A systematic review and meta-analysis of randomized controlled trials
Although some earlier studies have indicated the effect of phytosterol(PS) supplementation on serum lipoprotein(a) (Lp(a)) and free fatty acid (FFA) concentration, findings are still conflicting. We aimed to assess the impact of PS supplementation on serum Lp(a) and FFA concentration through a systematic review and meta-analysis of available RCTs. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 30, 2019 Category: Nutrition Authors: Somaye fatahi, HamedKord Varkaneh, Sam Talaei, Farzane Mardali, Jamal Rahmani, Ehsan Ghaedi, Shing Cheng Tan, Farzad Shidfar Tags: Systematic Reviews and Meta-analyses Source Type: research

Spiroergometric assessment of cardiorespiratory fitness in subjects with severe obesity: A challenge of reference
Severe obesity is associated with poor physical performance but objective data are scarce. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 27, 2019 Category: Nutrition Authors: B. Wilms, B. Ernst, S.M. Schmid, M. Thurnheer, B. Weisser, B. Schultes Source Type: research

No association between coffee consumption and risk of atrial fibrillation: a Mendelian randomization study
Some observational studies have found that habitual coffee and caffeine consumption might reduce the risk of atrial fibrillation (AF). We conducted a two-sample Mendelian randomization study to explore the potential association between coffee consumption and AF. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 27, 2019 Category: Nutrition Authors: Shuai Yuan, Susanna C. Larsson Source Type: research

Trend of salt intake measured by 24-hour urine collection samples among Iranian adults population between 1998 and 2013: The Isfahan Salt Study
Few population-based studies conducted in the Eastern Mediterranean region assessed salt intake by the measurement of 24-hour sodium urine excretion (24-hUNa). The current study aimed to assess the trend of mean salt intake in Iranian adults between 1998 and 2013. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 27, 2019 Category: Nutrition Authors: Noushin Mohammadifard, Alireza Khosravi, Jordi Salas-Salvad ó, Nerea Becerra-Tomás, Fatemeh Nouri, Zahra Abdollahi, Mahnaz Jozan, Ahmad Bahonar, Nizal Sarrafzadegan Source Type: research

Corrigendum to “Dietary acid load and risk of hypertension: A systematic review and dose-response meta-analysis of observational studies” [Nutr Metabol Cardiovasc Dis 29 (7) (July 2019) 665–675]
The authors regret that Mr. Nasiri's affiliations appeared incorrectly and should be as per the above. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 25, 2019 Category: Nutrition Authors: Mohammad Parohan, Alireza Sadeghi, Morteza Nasiri, Vahid Maleki, Mahmoud Khodadost, Aliyar Pirouzi, Omid Sadeghi Tags: Corrigendum Source Type: research

Efficacy of L-carnitine supplementation for management of blood lipids: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
L-carnitine has an important role in fatty acid metabolism and could therefore act as an adjuvant agent in the improvement of dyslipidemia. The purpose of present systematic review and meta-analysis was to critically assess the efficacy of L-carnitine supplementation on lipid profiles. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 24, 2019 Category: Nutrition Authors: Moein Askarpour, Amir Hadi, Michael E. Symonds, Maryam Miraghajani, Omid sadeghi, Ali Sheikhi, Ehsan Ghaedi Tags: Systematic Reviews and Meta-analyses Source Type: research

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions
Aim of this study involved assessment of the intensive intervention concerning lifestyle based on the DASH diet model on plasma concentration of CXCL4 chemokine among patients with coronary atherosclerosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 24, 2019 Category: Nutrition Authors: Magdalena Makarewicz-Wujec, Jan Henzel, Mariusz Kruk, Cezary K ępka, Łukasz Wardziak, Piotr Trochimiuk, Andrzej Parzonko, Marcin Demkow, Malgorzata Kozłowska-Wojciechowska Source Type: research

Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus
Dipeptidyl peptidase 4 (DPP4) is a key enzyme involved in the regulation of the incretin system exerted by cleaving the glucagon-like peptide 1 (GLP-1); the blockage of DPP4, exerted by the antidiabetic agents DPP4-inhibitors (DPP4-I), results in greater GLP-1 concentration and improved glycaemic control. DPP4 acts also as a pro-inflammatory molecule and mediates vascular damage in experimental models. The relationship between DPP4 activity and endothelial function in diabetes has not been explored yet. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 23, 2019 Category: Nutrition Authors: Barchetta I, Ciccarelli G, Barone E, Cimini FA, Ceccarelli V, Bertoccini L, Sentinelli F, Tramutola A, Del Ben M, Angelico F, Baroni MG, Lenzi A, Cavallo MG Source Type: research

Effect of palmitate and oleate on mitochondrial dynamics processes in hepatic cells HEPG2
Introduction: Mitochondria are organelles constantly submitted to fusion and fission processes (mitochondrial dynamics). Fission process is associated with mitochondrial disfunction, oxidative stress and apoptosis, and therefore with insulin resistance onset. On the other hand, fusion process is associated with the prevention of this metabolic alteration, being able to protect cells against insulin resistance. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Isy Faria de Sousa, Marilena Lepretti, Vincenzo Migliaccio, Gaetana Paolella, Eliane Beraldi Ribeiro, Lill à Lionetti Source Type: research

Activation of cytostatic autophagy by polar extract of hempseed oil (Cannabis sativa L.) in a colorectal adenocarcinoma cell line
Introduction: The hempseed oil, suitable for human feeding, can be obtained by cold pressing of seed belonging to a non-pharmaceutical hemp variety (Cannabis sativa L.). Beyond its nutritional value due to the ideal ratio (3:1) of essential polyunsaturated fatty acids, the presence of biomolecules, such as phytocannabinoids and polyphenols, has been also associated with potential beneficial effects. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Stefania Moccia, Maria Russo, Carmela Spagnuolo, Idolo Tedesco, Gianluca Picariello, Francesco Siano, Maria Grazia Volpe, Francesco La Cara, Gian Luigi Russo Source Type: research

A Phenolic Extract from Extra Virgin Olive Oil Induces Authophagy and Apopotosis in Human Bladder Cancer Cell Lines Depending on Tumor Progression
Introduction: The regular consumption of olive oil has associated with a protection against several diseases, including cancer. Epidemiological evidence indicate an inverse association between olive oil intake and bladder cancer risk. The phenolic fraction of olive oil plays a key role in this beneficial effect. Bladder cancer is one of the most common cancer in Europe, United States and Nord Africa. In particular, the transitional cell carcinoma histotype shows an aggressive behavior and the current therapies are ineffective. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Carmela Spagnuolo, Filomena Maria Conte, Maria Russo, Idolo Tedesco, Stefania Moccia, Maria Sicuranza, Rossella Scotti, Gian Luigi Russo Source Type: research

Red Wine Polyphenols Induce Adaptive Response in a Monocyte/Macrophage Murine Cell Line (J774)
Introduction: Recent studies confirmed that a moderate amount of wine may have health benefits. Experimental evidence suggested that these beneficial effects could be due to the polyphenol content of red wine. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Idolo Tedesco, Michela Russo, Carla Cicala, Maria Russo, Stefania Moccia, Carmela Spagnuolo, Gian Luigi Russo Source Type: research

Vitamin D analogue EB1089 sensitizes human transformed cell lines to gamma radiations by inducing lethal autophagy and apoptosis
Introduction: The gold standard for unresectable solid tumours and advanced forms of leukemia is represented by chemo-radiation. However, therapeutic options are limited and patients undergo systemic cytotoxicity. Vitamin D insufficiency is a widespread problem and its low serum levels are linked to higher cancer incidence. Previous studies showed a strong correlation between serum concentration of vitamin D and time of first treatment in chronic lymphocytic leukemia (CLL). Other studies demonstrated that vitamin D and its ipocalcemic analogue EB1089 are able to bypass radio-resistance in breast and lung cancer cell lines ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Maria Russo, Mariangela Basile, Francesco Messano, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Gian Luigi Russo Source Type: research

Autophagy flux modulation by a carotenoid-enriched extract from the pumpkin Cucurbita moschata on human chronic lymphocytic leukemia cell line
Introduction: Chronic lymphocytic leukemia (CLL) is the most frequent form of leukemia in adult population and chemotherapy resistance occurs in 15 –30% of patients with elevated genomic complexity. Apoptosis resistance and induction of a protective form of autophagy are possible explanations of the poor responsivity of CLL to conventional and novel therapeutic drugs. Given the difficulties to maintain in culture B-CLL lymphocytes, the HG3 ce ll line represents an interesting preclinical model to study the effects of natural bioactive molecules or extracts derived from food matrix as potential, chemo-sensitizers in C...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Maria Russo, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Carmen Cervellera, Gian Luigi Russo Source Type: research

Anti-inflammatory effects of blueberry extract in microglial cells
Background: Microglia (MG), the immunocompetent cells of the CNS, respond to brain injury activating and modifying their morphology. Microglia can exist broadly between two different activation states, namely the classical (M1) and the alternative activated (M2) phenotype. The first one is characterized by the production of pro-inflammatory cytokines, in contrast, the latter is characterized by the production of anti-inflammatory cytokines (Kettenmann et al., Neuron. 2013; 77:10 –18). Blueberry is involved in the control of the redox state of the cell, cooperating with antioxidant mechanisms, whereas its anti-inflamm...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Maria Giovanna De Caris, Elisa Maggi, Antonio Francioso, Maddalena Grieco, Luciana Mosca, Maria D'Erme, Alessandro Pinto, Patrizia Mancini, Rita Businaro Source Type: research

Intestinal epithelium responses to titanium dioxide nanoparticles
Introduction: Humans are exposed to nanoparticles from a variety of sources through a broad range of exposure ways since nanomaterials are increasingly used in different productive sectors. Titanium dioxide (TiO2) is enclosed in many consumer products including pharmaceuticals, cosmetics, and foods. TiO2 (E171) is daily ingested as mixed nano- and submicron-sized particles since it is approved as a white pigment in Europe in a variety of food products. Noteworthy, the relevant risk assessment has never been satisfactorily concluded and growing alarms for human hazards deriving from TiO2 exposure are incrementally reported....
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Antonella Venezia, Paola Pedata, Giulia Ricci, Livia Malorni, Nunzia Iannaccone, Marcella Cammarota, Maria Grazia Volpe, Vincenzo Guida, Chiara Schirardi, Marco Romano, Giuseppe Iacomino Source Type: research

Interplay between the toxic alpha-gliadin peptide 31-43 and type 2 transglutaminase enzyme in Celiac Disease
Introduction: Celiac disease (CD) is a widespread enteropathy triggered by a diet containing cereals with gliadins in genetically predisposed individuals. Alpha-gliadin peptide 31 –43 (p31-43) is considered the main responsible of the innate immune response in CD patients and type 2 transglutaminase (TG2) enzyme is involved in CD by enhancing gliadin immunogenicity. Evidence has been reported on a role of TG2 in modulate p31-43 uptake by intestinal cells; indeed, antibodies to TG2 specifically reduced both p31-43 uptake by cells and its biological activity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Gaetana Paolella, Marilena Lepretti, Stefania Martucciello, Lill à Lionetti, Carla Esposito, Ivana Caputo Source Type: research

Cellular and systemic analysis based on Polyunsaturated Fatty Acids protective effects against insulin- resistance condition
In this study, the protective effect was evaluated through: 1) serum parameters related to IR (HOMA index and apelin serum levels); 2) hepatic insulin signaling pathway markers (phosphorylated protein kinase B, p-Ser473-AKT/PKB); 3) endoplasmic reticulum (ER) stress marker (phosphorylated transcription factor p-eIF2α); 4) mitochondrial dynamics marker (Mitofusin 2, Mfn2). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Ilaria Di Gregorio, Anna Busiello Rosa, Marilena Lepretti, Vincenzo Migliaccio, Lill à Lionetti Source Type: research