Familial diabetes of the adulthood: a bin of ignorance that need to be addressed
The aim of this article was to share with a wide readership some data and related reasoning about a multigenerational form of diabetes mellitus of the adulthood. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 26, 2017 Category: Nutrition Authors: Sabrina Prudente, Ornella Ludovico, Vincenzo Trischitta Tags: Viewpoint Source Type: research

Low vitamin D status in relation to cardiovascular disease and mortality in Swedish women – Effect of extended follow-up
The impact of vitamin D concentrations on subsequent cardiovascular disease (CVD) and overall mortality has been generally examined for periods under two decades. The magnitude of the association may depend on follow-up length. We aimed to investigate the relationship between baseline vitamin D and risk of total CVD, stroke and all-cause mortality over three decades of follow-up. Secondly, we aimed to assess how follow-up affects the associations. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 25, 2017 Category: Nutrition Authors: M. Leu Agelii, S. Lehtinen-Jacks, H. Zetterberg, V. Sundh, C. Bj örkelund, L. Lissner Source Type: research

Low vitamin D status in relation to cardiovascular disease and mortality in Swedish women - effect of extended follow-up
The impact of vitamin D concentrations on subsequent cardiovascular disease (CVD) and overall mortality has been generally examined for periods under two decades. The magnitude of the association may depend on follow-up length. We aimed to investigate the relationship between baseline vitamin D and risk of total CVD, stroke and all-cause mortality over three decades of follow-up. Secondly, we aimed to assess how follow-up affects the associations. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 25, 2017 Category: Nutrition Authors: Monica Leu Agelii, Susanna Lehtinen-Jacks, Henrik Zetterberg, Valter Sundh, Cecilia Bj örkelund, Lauren Lissner Source Type: research

Hyperthyroxinemia is positively associated with prevalent and incident type 2 diabetes mellitus in two population-based samples from Northeast Germany and Denmark
A potential causal relationship between thyroid function and type 2 diabetes mellitus is currently under debate, but the current state of research is limited. Our aim was to investigate the association of thyroid hormone levels with prevalent and incident type 2 diabetes mellitus (T2DM) in two representative studies. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 25, 2017 Category: Nutrition Authors: T. Ittermann, S. Schipf, M. D örr, B.H. Thuesen, T. Jørgensen, H. Völzke, M.R.P. Markus Source Type: research

Adverse events with sodium-glucose co-transporter-2 inhibitors: A  global analysis of international spontaneous reporting systems
We assessed post-marketing safety of sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) by analyzing adverse events (AEs) reported in international pharmacovigilance databases. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2017 Category: Nutrition Authors: E. Raschi, M. Parisotto, E. Forcesi, M. La Placa, G. Marchesini, F. De Ponti, E. Poluzzi Source Type: research

Adverse events with sodium-glucose co-transporter-2 inhibitors: a global analysis of international spontaneous reporting systems
We assessed post-marketing safety of sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) by analyzing adverse events (AEs) reported in international pharmacovigilance databases. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2017 Category: Nutrition Authors: E. Raschi, M. Parisotto, E. Forcesi, M. La Placa, G. Marchesini, F. De Ponti, E. Poluzzi Source Type: research

Association of serum fibroblast growth factor 19 levels with visceral fat accumulation is independent of glucose tolerance status
This study aimed to investigate the association of serum FGF19 levels with obesity and visceral fat accumulation in a Chinese population with differing glucose tolerance status. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2017 Category: Nutrition Authors: Xiang Hu, MD, Qin Xiong, MD, Yiting Xu, Xueli Zhang, Xiaoping Pan, Xiaojing Ma, PhD. MD, Yuqian Bao, MD, Weiping Jia, Hu X, Xiong Q, Xu Y, Zhang X, Pan X, Ma X, Bao Y, Jia W Source Type: research

A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease
Over the last 7 years there has been intense debate about the advice to reduce saturated fat and increase polyunsaturated fat to reduce CVD risk. The aim of this review was to examine systematic reviews and meta-analyses since 2010 on this topic plus additional cohort studies and interventions not included in these reviews. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2017 Category: Nutrition Authors: Peter M. Clifton, Jennifer B. Keogh Source Type: research

Acute Renal Failure with Sodium-Glucose-Cotransporter-2 Inhibitors: Analysis of the FDA Adverse Event Report System Database
This study aimed to evaluate the association between SGLT2-inhibitors and ARF in the FDA adverse event report system (FAERS) database. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2017 Category: Nutrition Authors: Amichai Perlman, Samuel N. Heyman, Ilan Matok, Joshua Stokar, Mordechai Muszkat, Auryan Szalat Source Type: research

Interrelationship of the rs7903146 TCF7L2 gene variant with measures of glucose metabolism and adiposity: the NEO Study
We investigated the interrelationship of rs7903146-T in TCF7L2 with measures of glucose metabolism and measures of adiposity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 17, 2017 Category: Nutrition Authors: R. Noordam, C.P.A. Zwetsloot, R. de Mutsert, D.O. Mook-Kanamori, H.J. Lamb, A. de Roos, E.J.P. de Koning, F.R. Rosendaal, K. Willems van Dijk, D. van Heemst Source Type: research

Sleep-disordered breathing and epicardial adipose tissue in patients with heart failure
Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), contributes to the progression of cardiac disease, and is associated with adverse prognosis. Previous evidence indicates that epicardial adipose tissue (EAT) is independently associated with sleep apnea in obese individuals. We explored the relationship between SDB and EAT in HF patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: V. Parisi, S. Paolillo, G. Rengo, R. Formisano, L. Petraglia, F. Grieco, C. D'Amore, S. Dellegrottaglie, C. Marciano, N. Ferrara, D. Leosco, P.P. Filardi Source Type: research

Prediabetes is associated with lower brain gray matter volume in the general population. The Study of Health in Pomerania (SHIP)
We investigated the associations of fasting (FG) and 2-h  postload (2HG) plasma glucose from oral glucose tolerance test (OGTT) with gray (GMV) and white (WMV) matter volume. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: M.R.P. Markus, T. Ittermann, K. Wittfeld, S. Schipf, U. Siewert-Markus, M. Bahls, R. B ülow, N. Werner, D. Janowitz, S.E. Baumeister, S.B. Felix, M. Dörr, W. Rathmann, H. Völzke, H.J. Grabe Tags: Meta-analysis Source Type: research

Inflammation in metabolically healthy and metabolically abnormal adolescents: the HELENA study
Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. To assess the inflammatory status by metabolic health/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: Esther Mar ía Gonzalez-Gil, Cristina Cadenas-Sanchez, Javier Santabárbara, Gloria Bueno-Lozano, Iris Iglesia, Marcela González-Gross, Denes Molnar, Frederic Gottrand, Stefaan De Henauw, Antonios Kafatos, Kurt Widhalm, Yannis Manios, Alfonso Siani, Fran Source Type: research

Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response
The incretin effect is impaired in type 2 diabetes (T2D), but the underlying mechanisms are only partially understood. We investigated the relationships between the time course of the incretin effect and that of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) during oral glucose tolerance tests (OGTTs), thereby estimating incretin sensitivity of the beta cell, and its associated factors. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: A. Tura, J.I. Bagger, E. Ferrannini, J.J. Holst, F.K. Knop, T. Vilsb øll, A. Mari Source Type: research

Sleep disordered breathing and epicardial adipose tissue in patients with heart failure
Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), contributes to the progression of cardiac disease and is associated to adverse prognosis. Previous evidences indicate that epicardial adipose tissue (EAT) is independently associated with sleep apnea in obese individuals. We explored the relationship between SDB and EAT in HF patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: Valentina Parisi, Stefania Paolillo, Giuseppe Rengo, Roberto Formisano, Laura Petraglia, Fabrizio Grieco, Carmen D ’Amore, Santo Dellegrottaglie, Caterina Marciano, Nicola Ferrara, Dario Leosco, Pasquale Perrone Filardi Source Type: research

Dietary total, animal, vegetable calcium and type 2 diabetes incidence among Korean adults: The Korean Multi-Rural Communities Cohort (MRCohort)
This study aimed to evaluate the prospective association between dietary calcium and T2D incidece among adults 40 years of age or over, from the Multi-rural Communities Cohort (MRCohort), South Korea. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: Jin Myoung Oh, Hye Won Woo, Mi Kyung Kim, Young-Hoon Lee, Dong Hoon Shin, Min-Ho Shin, Bo Youl Choi Source Type: research

Prediabetes is Associated with Lower Brain Gray Matter Volume in the General Population The Study of Health in Pomerania (SHIP)
We investigated the associations of fasting (FG) and 2-hour postload (2HG) plasma glucose from oral glucose tolerance test (OGTT) with gray (GMV) and white (WMV) matter volume. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 13, 2017 Category: Nutrition Authors: M.R.P. Markus, T. Ittermann, K. Wittfeld, S. Schipf, U. Siewert-Markus, M. Bahls, R. B ülow, N. Werner, D. Janowitz, S.E. Baumeister, S.B. Felix, M. Dörr, W. Rathmann, H. Völzke, H.J. Grabe Source Type: research

The association between muscle mass deficits and arterial stiffness in middle-aged men
Early diagnosis of arteriosclerosis is fundamental for the prevention of cardiovascular morbidity and mortality. The current study was performed to identify major predictors of arteriosclerosis and to assess the association between arterial stiffness as measured by cardio-ankle vascular index (CAVI) and muscle mass deficit (MMD) estimated by bioelectrical impedance analysis (BIA) in middle-aged men. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 11, 2017 Category: Nutrition Authors: I.J. Im, H.J. Choi, S.M. Jeong, H.J. Kim, J.S. Son, H.J. Oh Source Type: research

The Relationship between High-density Lipoprotein Cholesterol Levels and Arterial Stiffness in a Taiwanese Population
There are few studies on the association between HDL-C levels and arterial stiffness (AS). The HDL-C level varies in males and females, and it is not clear whether the relationship between the HDL-C level and AS is influenced by gender. The purpose of this study was to investigate the gender differences in the association between HDL-C levels and AS in adults. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 11, 2017 Category: Nutrition Authors: Wei-Chen Shen, Feng-Hwa Lu, Yi-Ching Yang, Jin-Shang Wu, Yin-Fan Chang, Yao-Hsien Huang, Chih-Jen Chang Source Type: research

Sex differences in associations between blood lipids and cerebral small vessel disease
Dyslipidemia predicts higher risk of coronary events and stroke and might be associated with cerebral small vessel disease (SVD). Previous studies linking blood lipids and SVD have yielded inconsistent results, which may be attributable to sex differences in lipids metabolism. The aim of this study was to investigate the relationships between blood lipids and SVD in neurologically healthy men and women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 10, 2017 Category: Nutrition Authors: Ze-Gang Yin, Qing-Song Wang, Ke Yu, Wei-Wen Wang, Hang Lin, Zheng-Hui Yang Source Type: research

The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials
Dietary fiber intake, especially viscous soluble fiber, has been established as a means to reduce cardiometabolic risk factors. Whether this is true for blood pressure remains controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of viscous soluble fiber supplementation on blood pressure and quantify the effect of individual fibers. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 7, 2017 Category: Nutrition Authors: K. Khan, E. Jovanovski, H.V.T. Ho, A.C.R. Marques, A. Zurbau, S.B. Mejia, J.L. Sievenpiper, V. Vuksan Tags: Systematic Reviews and Meta-analyses Source Type: research

Serum Fetuin-A Levels in Obese Children with Biopsy Proven Nonalcoholic Fatty Liver Disease
Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obese children with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 3, 2017 Category: Nutrition Authors: V. Pampanini, E. Inzaghi, D. Germani, A. Alterio, A. Puglianiello, A. Alisi, V. Nobili, S. Cianfarani Source Type: research

Identification of serum metabolites associated with obesity and traditional risk factors for metabolic disease in Chinese adults
Obesity is a major worldwide health problem and is often associated with many metabolic diseases. Levels of several serum-specific metabolites may be altered in patients with these metabolic diseases. We aimed to investigate the associations of serum metabolite levels with obesity and traditional risk factors for metabolic disease in Chinese individuals. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 3, 2017 Category: Nutrition Authors: S.M. Wang, R.Y. Yang, M. Wang, F.S. Ji, H.X. Li, Y.M. Tang, W.X. Chen, J. Dong Source Type: research

Relationship between Mediterranean Diet and asymptomatic peripheral arterial disease in a population of pre-menopausal women
Mediterranean Diet (MedD) is considered a very healthy diet useful in the prevention of cardiovascular disease. The present study aims to evaluate adherence to MedD in unselected premenopausal women and its relation with ankle-brachial index (ABI), an index of preclinical atherosclerosis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 3, 2017 Category: Nutrition Authors: A.V. Mattioli, F. Coppi, M. Migaldi, P. Scicchitano, M.M. Ciccone, A. Farinetti Source Type: research

Phytosterol-enriched milk lowers LDL-cholesterol levels in Brazilian children and adolescents: Double-blind, cross-over trial
Despite evidence of the lipid-lowering effect of plant sterols among adults with hypercholesterolemia, data regarding phytosterol use in children are limited. In this paper, we examined the effects of daily consumption of a phytosterol-enriched milk compound on the lipid profiles of Brazilian children and adolescents with dyslipidemia. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 2, 2017 Category: Nutrition Authors: S.A. Ribas, R. Sichieri, A.S.B. Moreira, D.O. Souza, C.T.F. Cabral, D.T. Gianinni, D.B. Cunha Source Type: research

Phytosterol- enriched milk lowers LDL-cholesterol levels in Brazilian children and adolescents: double-blind, cross-over trial
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 2, 2017 Category: Nutrition Authors: S.A. Ribas, R. Sichieri, A.S.B. Moreira, D.O. Souza, C.T.F. Cabral, D.T. Gianinni, D.B. Cunha Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 1, 2017 Category: Nutrition Source Type: research

Efficacy and safety of glucagon-like peptide-1 agonists on macrovascular and microvascular events in type 2 diabetes mellitus: a metanalysis
Glucagon-like peptide-1 (GLP-1) agonists improve glycemic control in type 2 diabetes mellitus (DM). Outcome trials investigating macro and microvascular effects of GLP-1 agonists reported conflicting results. The aim of this study was to assess, in a metanalysis, the effects of GLP-1 agonists on mortality, major nonfatal cardiovascular (CV) events, renal and retinal events. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 26, 2017 Category: Nutrition Authors: P. Gargiulo, G. Savarese, C. D ’Amore, F. De Martino, L.H. Lund, F. Marsico, S. Dellegrottaglie, C. Marciano, B. Trimarco, P. Perrone-Filardi Source Type: research

A comparison of gamma-glutamyl transferase and alkaline phosphatase as prognostic markers in patients with coronary heart disease
Whether gamma-glutamyl transferase (GGT) or alkaline phosphatase (ALP) is a better prognostic marker in patients with coronary heart disease (CHD) remains unknown. The aim of this study was to compare the prognostic value of GGT and ALP in patients with CHD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 23, 2017 Category: Nutrition Authors: Gjin Ndrepepa, Stefan Holdenrieder, Salvatore Cassese, Massimiliano Fusaro, Erion Xhepa, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati Source Type: research

Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: a multicenter, randomized, double-blind, placebo-controlled trial
Suboptimal health and metabolic disorders are common in the general population. Both are related to cardiovascular disease. Suboptimal cardiovascular health is defined by the presence of both suboptimal health and metabolic disorders. The aim of the study was to investigate the potential benefit of n-3 long-chain polyunsaturated fatty acids (LCPUFA) in participants with suboptimal cardiovascular health. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 20, 2017 Category: Nutrition Authors: Qiang Zeng, Sheng-Yong Dong, Yu-Ping Liu, Jun Fu, Ping Shuai, Zhi-Ming Zhao, Ting-Xin Li Source Type: research

Association of dietary patterns with five-year degree and progression of coronary artery calcification in the Heinz Nixdorf Recall study
As a modifiable lifestyle factor diet is hypothesized to play an important role in the progression of atherosclerosis. The aim of this study was to explore associations of comprehensive dietary patterns derived by cluster analysis with degree and progression of coronary artery calcification (CAC) over five years of follow-up. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 16, 2017 Category: Nutrition Authors: S. Fr ölich, N. Lehmann, S. Weyers, S. Wahl, N. Dragano, T. Budde, H. Kälsch, A.A. Mahabadi, R. Erbel, S. Moebus, K.H. Jöckel, B. Schmidt, Heinz Nixdorf Recall Study Investigators Source Type: research

Disease Trends Over Time and CD4+CCR5+ T-Cells Expansion Predict Carotid Atherosclerosis Development in Patients with Systemic Lupus Erythematosus
Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies assessed long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the association of clinical and laboratory markers of disease activity and of classical cardiovascular risk factors (CVRF) with carotid atherosclerosis development in patients with SLE in a prospective 5-year study. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 15, 2017 Category: Nutrition Authors: A. Baragetti, G.A. Ramirez, M. Magnoni, K. Garlaschelli, L. Grigore, M. Berteotti, I. Scotti, E. Bozzolo, A. Berti, P.G. Camici, A.L. Catapano, A.A. Manfredi, E. Ammirati, G.D. Norata Source Type: research

Western diet increases cardiac ceramide content in healthy and hypertrophied hearts
Obesity and cardiac left ventricular hypertrophy (LVH) are recognised independent risk factors in the development of heart failure (HF). However, the combination of these factors may exacerbate the onset of cardiovascular disease by mechanisms as yet unclear. LVH leads to significant cellular remodelling, including alterations in metabolism which may result in an inappropriate accumulation of lipids and eventual lipotoxicty and apoptosis. The aim of the study was to determine the impact of dietary manipulation on cardiac metabolism in the obese and hypertrophied heart. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 7, 2017 Category: Nutrition Authors: T.J. Butler, D. Ashford, A.-M. Seymour Source Type: research

Association between Obesity and risk of Chronic Kidney Disease: A Nationwide Cohort Study in Taiwan
Increased body fat relates to enhanced inflammatory cytokine production, which, in turn, activates the renin-angiotensin-aldosterone system and increases the risk of chronic kidney disease (CKD). Herein, we aimed to examine the association between obesity and the risk of CKD in a population-representative cohort in Taiwan. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 25, 2017 Category: Nutrition Authors: Yun-Ju Lai, Hsiao-Yun Hu, Ya-Ling Lee, Po-Wen Ku, Yung-Feng Yen, Dachen Chu Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 22, 2017 Category: Nutrition Source Type: research

Saffron (Crocus sativus) intake provides nutritional preconditioning against myocardial ischemia –reperfusion injury in Wild Type and ApoE(−/−) mice: Involvement of Nrf2 activation
Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE( −/−) mice and the underlying molecular mechanisms. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 22, 2017 Category: Nutrition Authors: P. Efentakis, A. Rizakou, E. Christodoulou, A. Chatzianastasiou, M.G. L ópez, R. León, E. Balafas, N.P.E. Kadoglou, I. Tseti, H. Skaltsa, N. Kostomitsopoulos, E.K. Iliodromitis, G. Valsami, I. Andreadou Source Type: research

Fish intake is associated with lower cardiovascular risk in a Mediterranean population: prospective results from the Moli-sani study
Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 22, 2017 Category: Nutrition Authors: Marialaura Bonaccio, Emilia Ruggiero, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, the Moli-sani study Investigators Source Type: research

Saffron (Crocus sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in Wild Type and ApoE(-/-) mice: involvement of Nrf2 activation
Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE(-/-) mice and the underlying molecular mechanisms. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 22, 2017 Category: Nutrition Authors: P. Efentakis, A. Rizakou, E. Christodoulou, A. Chatzianastasiou, M.G. L ópez, R. León, E. Balafas, N.P.E. Kadoglou, I. Tseti, H. Skaltsa, N. Kostomitsopoulos, E.K. Iliodromitis, G. Valsami, I. Andreadou Source Type: research

The role of glucose, insulin and NEFA in regulating tissue triglyceride accumulation: substrate cooperation in adipose tissue versus substrate competition in skeletal muscle
Metabolic factors initiating adipose tissue expansion and ectopic triglyceride accumulation are not completely understood. We aimed to investigate the independent role of circulating glucose, NEFA and insulin on glucose and NEFA uptake, and lipogenesis in skeletal muscle and subcutaneous adipose tissue (SCAT). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 16, 2017 Category: Nutrition Authors: Maria-Angela Guzzardi, Leanne Hodson, Letizia Guiducci, Federica La Rosa, Piero A. Salvadori, Silvia Burchielli, Patricia Iozzo Source Type: research

Single Blind, Multicentre, Randomized, Controlled Trial Testing The Effects of A Novel Nutraceutical Compound on Plasma Lipid and Cardiovascular Risk Factors: Results of The Interim Analysis
The clustering of high levels of LDL cholesterol (LDL-C) and other risk factors represents a predisposing condition for atherosclerotic disease development. Cardiovascular prevention is based on effective control of these conditions. In adult subjects with mild hypercholesterolemia we compared in the real life the effects of a new combination of nutraceuticals on lipid and glucose metabolism and blood pressure with those of an established nutraceutical combination. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 14, 2017 Category: Nutrition Authors: Valentina Trimarco, Allegra Battistoni, Giuliano Tocci, Roberta Coluccia, Maria Virginia Manzi, Raffaele Izzo, Massimo Volpe Source Type: research

Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes)
Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 7, 2017 Category: Nutrition Authors: G.P. Fadini, G. Zatti, A. Consoli, E. Bonora, G. Sesti, A. Avogaro, DARWIN-T2D Network Source Type: research

Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes) A multicenter retrospective nationwide Italian study and crowdsourcing opportunity
Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 7, 2017 Category: Nutrition Authors: Gian Paolo Fadini, Giancarlo Zatti, Agostino Consoli, Enzo Bonora, Giorgio Sesti, Angelo Avogaro, DARWIN-T2D network Source Type: research

Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis
The rapidly growing discipline of lipidomics allows the study of a wide spectrum of lipid species in body fluids and provides new insights into the pathogenesis of cardiovascular disease. We investigated serum phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) species in relation to arterial stiffness, hemodynamics, and endothelial dysfunction in symptomatic patients with atherosclerosis and in healthy controls. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 2, 2017 Category: Nutrition Authors: K. Paapstel, J. Kals, J. Eha, K. Tootsi, A. Ottas, A. Piir, M. Jakobson, J. Lieberg, M. Zilmer Source Type: research

Serum phosphatidylcholines and lysophosphatidylcholines are inversely related to vascular damage and heart rate in patients with atherosclerosis
The rapidly growing discipline of lipidomics allows to study a wide spectrum of lipid species in body fluids and provides new insights into the pathogenesis of cardiovascular disease. We investigated serum phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) species in relation to arterial stiffness, hemodynamics and endothelial dysfunction in symptomatic patients with atherosclerosis and in healthy controls. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 2, 2017 Category: Nutrition Authors: K. Paapstel, J. Kals, J. Eha, K. Tootsi, A. Ottas, A. Piir, M. Jakobson, J. Lieberg, M. Zilmer Source Type: research

Are bariatric and metabolic surgeries synonymous? – A nutritional view
With a significant increase in super (severely)-obese patient populations [1], the difficult and often unsuccessful pharmacological and non-pharmacological treatments of the obesity epidemic have favored the spread of surgical options, i.e., bariatric surgery, in the last 30 years [2 –4]. Over these years, several surgical options [5] have been suggested, aiming at obtaining a significant (more than 20%) and stable weight loss and stable control of (metabolic, cardiovascular, respiratory, etc.) complications. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 1, 2017 Category: Nutrition Authors: F. Contaldo, L. Santarpia, F. Pasanisi Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 1, 2017 Category: Nutrition Source Type: research

Substitution of water or fresh juice for bottled juice and type 2 diabetes incidence: the SUN cohort study
The relationship between juice consumption and type 2 diabetes (T2D) has not been widely evidenced. Our aims were to prospectively evaluate the associations with T2D incidence of: 1) isovolumetric substitution of a water serving/day for one of fruit juice (different types), and of fresh fruit juice for its bottled version; 2. consumption of total, fresh or bottled juice; 3. energy intake from juices. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 1, 2017 Category: Nutrition Authors: U. Fres án, A. Gea, M. Bes-Rastrollo, F.J. Basterra-Gortari, S. Carlos, M.A. Martínez-Gonzalez Source Type: research

Are bariatric and metabolic surgery synonymous?a nutritional view
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 1, 2017 Category: Nutrition Authors: Franco Contaldo, Lidia Santarpia, Fabrizio Pasanisi Tags: Letter to the Editor Source Type: research

Vitamin D Deficiency and clinical outcome in patients with Chronic Heart Failure: a Review
The aim of this review was to summarize evidence on the role of Vitamin D deficiency in heart failure (HF), from pathophysiological mechanisms to clinical effects of Vitamin D supplementation. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 29, 2017 Category: Nutrition Authors: C. D ’Amore, F. Marsico, A. Parente, S. Paolillo, F. De Martino, P. Gargiulo, F. Ferrazzano, A.M. De Roberto, L. La Mura, C. Marciano, S. Dellegrottaglie, B. Trimarco, P. Perrone Filardi Tags: Review Source Type: research

Amino acid profile and metabolic syndrome in a male Mediterranean population: A cross-sectional study
The metabolic syndrome (MetS) refers to a cluster of clinically relevant factors that increases the risk of cardiovascular diseases and all-cause mortality. Circulating levels of several amino acids and metabolites related to one-carbon metabolism have been associated with cardiometabolic risk factors and MetS. We aimed to identify the amino acid profile that is significantly associated with MetS among an all male Mediterranean population. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 24, 2017 Category: Nutrition Authors: A. Ntzouvani, T. Nomikos, D. Panagiotakos, E. Fragopoulou, C. Pitsavos, A. McCann, P.M. Ueland, S. Antonopoulou Source Type: research