Bariatric Surgery, Diabetes Mellitus, and Epicardial Adipose Tissue
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 11, 2017 Category: Nutrition Authors: Zeynep Cerit Tags: Letter to the Editor Source Type: research

A pro-inflammatory diet is associated with increased risk of developing hypertension among middle-aged women
– A pro-inflammatory diet is thought to lead to hypertension through oxidative stress and vessel wall inflammation. We therefore investigated the association between the dietary inflammatory index (DII) and developing hypertension in a population-based cohort of middle-aged women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 29, 2017 Category: Nutrition Authors: L.E.T. Vissers, M. Waller, Y.T. van der Schouw, J.R. H ébert, N. Shivappa, D.A.J.M. Schoenaker, G.D. Mishra Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 26, 2017 Category: Nutrition Source Type: research

Response to Gentile S et  al.: Risk factors for severe hypoglycaemia in people with insulin-treated diabetes: Are we sure we took into account all variables involved?
We thank Gentile et  al. [1] for their interest and comments on our recent article focusing on risk factors for restrictively defined severe hypoglycaemia (SH) in people with type 1 diabetes (T1DM) [2]. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 18, 2017 Category: Nutrition Authors: A. Holstein, T. Wohland, O.M. Patzer, P. Kovacs, J.D. Holstein Tags: Letter to the Editor Source Type: research

Response to Gentile S et al.: Risk factors for severe hypoglycaemia in people with insulin-treated diabetes: Are we sure we took into account all variables involved?
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 18, 2017 Category: Nutrition Authors: A. Holstein, T. Wohland, O.M. Patzer, P. Kovacs, J.D. Holstein Tags: Letter to the Editor Source Type: research

Statin Use and Risk of New-Onset Diabetes: A Meta-Analysis of Observational Studies
Meta-analyses of randomized control trials investigating the association between incident diabetes and statin use showed an increased risk of new-onset diabetes (NOD) from 9% to 13% associated with statins. However, short follow-up period, unpowered sample size, and lack of pre-specified diagnostic criteria for diabetes detection could be responsible of an underestimation of this risk. We conducted a meta-analysis of published observational studies to evaluate the association between statins use and risk of NOD. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 10, 2017 Category: Nutrition Authors: M. Casula, F. Mozzanica, L. Scotti, E. Tragni, A. Pirillo, G. Corrao, A.L. Catapano Tags: Systematic Reviews and Meta-analyses Source Type: research

Relationship between high white blood cell count and insulin resistance (HOMA-IR) in Korean children and adolescents: Korean National Health and Nutrition Examination Survey 2008-2010
This study aimed to examine the association between WBC count and insulin resistance as measured by HOMA-IR in a nationally representative sample of children and adolescents. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 10, 2017 Category: Nutrition Authors: Jae-Min Park, Duk-Chul Lee, Yong-Jae Lee Source Type: research

Adipokines as atherothrombotic risk factors in obese subjects: associations with haemostatic markers and common carotid wall thickness
Some crucial associations between obesity-related altered adipokine levels and the main factors of atherosclerotic, atherothrombotic processes are not fully known. We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumor necrosis factor-alpha (TNF- α), interleukin 6 (IL-6) with the markers of platelet activation, including mean platelet volume (MPV), platelet surface/soluble P-selectin, platelet-derived microparticles (PMPs), the parameters of coagulation abnormalities and common carotid intima-media thickness (IMT) in obese patients with or without atherosclerotic comorbiditie...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 8, 2017 Category: Nutrition Authors: Éva Csongrádi, Miklós Káplár, Béla Nagy Jr, Christian A. Koch, Attila Juhász, László Bajnok, Zsuzsa Varga, Ildikó Seres, Zsolt Karányi, Mária T. Magyar, László Oláh, Andrea Facskó, János Kappelmayer, György Paragh Source Type: research

Correlation between serum uric acid levels and residual platelet reactivity in patients undergoing PCI
Uric acid has been demonstrated within atherosclerotic plaque, where it may lead to thrombus formation by increasing platelet adhesiveness and altering the normal platelet reactivity [1,2]. Increased platelet reactivity has been associated with ischemic events in patients with coronary atherosclerosis [3]. In particular, recurrent ischemic events and increased risk of stent thrombosis were reported in patients undergoing percutaneous coronary intervention (PCI) in the presence of high residual platelet reactivity (HPR) despite treatment with dual anti-platelet therapy (DAPT) with aspirin (ASA) and P2Y12 inhibitors (e.g. (S...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 4, 2017 Category: Nutrition Authors: G. Ciccarelli, F. Mangiacapra, M. Pellicano, E. Barbato Tags: Letter to the Editor Source Type: research

Correlation between Serum Uric Acid and Residual Platelet Reactivity in Patients undergoing PCI
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - March 4, 2017 Category: Nutrition Authors: Giovanni Ciccarelli, Fabio Mangiacapra, Mariano Pellicano, Emanuele Barbato Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 25, 2017 Category: Nutrition Source Type: research

Geriatric nutritional risk index as a nutritional and survival risk assessment tool in stable outpatients with systolic heart failure
This study aimed to evaluate the incremental prognostic value of the geriatric nutritional risk index (GNRI) in stable geriatric outpatients with HFrEF compared with a clinical/laboratory prognostic model. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 23, 2017 Category: Nutrition Authors: L. Sargento, A. Vicente Sim ões, J. Rodrigues, S. Longo, N. Lousada, R. Palma dos Reis Source Type: research

Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice
Anthracyclines are effective anticancer drugs that have improved prognosis of hundred thousand cancer patients worldwide and are currently the most common chemotherapeutic agents used for the treatment of blood, breast, ovarian and lung cancers. However, their use is limited because of a cumulative dose-dependent and irreversible cardiotoxicity that can cause progressive cardiomyopathy and congestive heart failure. Aim of the present study was to determine the cardioprotective activity of a dietary source of cyanidin 3-glucoside (C3G), such as purple corn, against doxorubicin (DOX) -induced cardiotoxicity in mice. (Source:...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 21, 2017 Category: Nutrition Authors: K. Petroni, M. Trinei, M. Fornari, V. Calvenzani, A. Marinelli, L.A. Micheli, R. Pilu, A. Matros, H.-P. Mock, C. Tonelli, M. Giorgio Source Type: research

Stem cells to restore insulin production and cure diabetes
The advancement of knowledge in the field of regenerative medicine is increasing the therapeutic expectations of patients and clinicians on cell therapy approaches. Within these, stem cell therapies are often evoked as a possible therapeutic option for diabetes, already ongoing or possible in the near future. The purpose of this document is to make a point of the situation on existing knowledge and therapies with stem cells to treat patients with diabetes by focusing on some of the aspects that most frequently raise curiosity and discussion in clinical practice and in the interaction with the patient. (Source: Nutrition, M...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 21, 2017 Category: Nutrition Authors: V. Sordi, S. Pellegrini, M. Krampera, P. Marchetti, A. Pessina, G. Ciardelli, G. Fadini, C. Pintus, G. Pant è, L. Piemonti Source Type: research

Risk factors for severe hypoglycemia in people with insulin-treated diabetes: are we sure we took into account all variables involved?
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 21, 2017 Category: Nutrition Authors: S. Gentile, G. Guarino, G. Marino, F. Strollo Source Type: research

The impact of using sagittal abdominal diameter to predict major cardiovascular events in European patients with type 2 diabetes
Obesity is associated with diabetes type 2 and one of the most important risk factors for cardiovascular disease. We explored if sagittal abdominal diameter (SAD) is a better predictor of major cardiovascular events than waist circumference (WC) and body mass index (BMI) in type 2 diabetes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 15, 2017 Category: Nutrition Authors: Karin R ådholm, Anders Tengblad, Elsa Dahlén, Toste Länne, Jan Engvall, Fredrik H. Nystrom, Carl Johan Östgren Source Type: research

Claimed effects, outcome variables and methods of measurement for health claims proposed under european community regulation 1924/2006 in the framework of protection against oxidative damage and cardiovascular health
The high number of negative opinions from the European Food Safety Authority (EFSA) to the requests for authorization of health claims is largely due to the design of human intervention studies, including the inappropriate choice of outcome variables (OVs) and of their methods of measurement (MMs). The present manuscript reports the results of an investigation aimed to collect, collate and critically analyse the information in relation to claimed effects, OVs and MMs, in the context of protection against oxidative damage and cardiovascular health compliant with Regulation 1924/2006. (Source: Nutrition, Metabolism, and Card...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 12, 2017 Category: Nutrition Authors: D. Martini, S. Rossi, B. Biasini, I. Zavaroni, G. Bedogni, M. Musci, C. Pruneti, G. Passeri, M. Ventura, S. Di Nuzzo, D. Galli, P. Mirandola, M. Vitale, A. Dei Cas, R.C. Bonadonna, D. Del Rio Source Type: research

High baseline C-reactive protein levels predict partial type 2 diabetes mellitus remission after biliopancreatic diversion
Several studies demonstrated that surgery can improve inflammation parameters, such as C-reactive protein (CRP). Few biomarkers have been investigated to potentially predict type 2 diabetes remission (T2DM) remission. We aimed at determining whether pre-surgery serum CRP levels could predict T2DM remission after 3 years in patients undergoing bariatric surgery, especially biliopancreatic diversion (BPD). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 3, 2017 Category: Nutrition Authors: Aldo Bonaventura, Luca Liberale, Federico Carbone, Nicola Scopinaro, Giovanni Bruno Camerini, Francesco Saverio Papadia, Renzo Cordera, Franco Dallegri, Gian Franco Adami, Fabrizio Montecucco Source Type: research

Editorial Board
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 1, 2017 Category: Nutrition Source Type: research

Psychological distress, Self-Efficacy and Glycemic Control in Type 2 Diabetes
To investigate the association of glycemic control with depression, anxiety, self-efficacy and other diabetes-specific psychological measures in a cohort of adult patients with type 2 diabetes (T2D) free of severe chronic diabetes-related complications. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 31, 2017 Category: Nutrition Authors: L. Indelicato, M. Dauriz, L. Santi, F. Bonora, C. Negri, V. Cacciatori, G. Targher, M. Trento, E. Bonora Source Type: research

A novel and useful predictive indicator of prognosis in ST-segment elevation myocardial infarction, the prognostic nutritional index
The prognostic impact of poor nutritional status and cardiac cachexia in myocardial infarction is not clearly understood. Recent studies have implied a prognostic value of the prognostic nutritional index (PNI) in colorectal surgeries and postoperative septic complications. The present study aimed to evaluate the prognostic value of PNI in ST-segment elevation myocardial infarction (STEMI) patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 18, 2017 Category: Nutrition Authors: M. Keskin, M. İ. Hayıroğlu, T. Keskin, A. Kaya, M.A. Tatlısu, S. Altay, A.O. Uzun, E.B. Börklü, T.S. Güvenç, İ.İ. Avcı, Ö. Kozan Source Type: research

Food group consumption in an Italian population using the updated food classification system FoodEx2: Results from the Italian Nutrition & HEalth Survey (INHES) study
Dietary habits evolve over time, being influenced by many factors and complex interactions. This work aimed at evaluating the updated information on food group consumption in Italy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 18, 2017 Category: Nutrition Authors: George Pounis, Americo Bonanni, Emilia Ruggiero, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Marialaura Bonaccio, Chiara Cerletti, Gabriele Riccardi, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, INHES investigators Source Type: research

A novel and useful predictive indicator of prognosis in ST-segment elevation myocardial infarction; prognostic nutritional index
The prognostic impact of poor nutritional status and cardiac cachexia in myocardial infarction is not clearly understood. Recent studies have implied a prognostic value of the prognostic nutritional index (PNI) in colorectal surgeries and postoperative septic complications. The purpose of the current study is to evaluate the prognostic value of PNI in ST segment elevation myocardial infarction (STEMI) patients. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 18, 2017 Category: Nutrition Authors: Muhammed Keskin, Mert İlker Hayıroğlu, Taha Keskin, Adnan Kaya, Mustafa Adem Tatlısu, Servet Altay, Ahmet Okan Uzun, Edibe Betül Börklü, Tolga Sinan Güvenç, İlhan İlker Avcı, Ömer Kozan Source Type: research

Back to glycemic control: an alternative look at the results of cardiovascular outcome trials in type 2 diabetes
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 16, 2017 Category: Nutrition Authors: Edoardo Mannucci, Matteo Monami, Antonio Ceriello, Carlo M. Rotella Tags: Letter to the Editor Source Type: research

Associations Between Common Carotid Artery Diameter, Framingham Risk Score and Cardiovascular Events
Vascular biomarkers are associated with risk burden and are capable to predict the development of future cardiovascular (CV) events; yet, their additive predictive value over and above established risk algorithms seems to be only modest. The present study evaluated the cross-sectional associations between vascular biomarkers, 10-year Framingham risk (FR) and prevalent CV events in a population with a high prevalence of hypertension and diabetes. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 14, 2017 Category: Nutrition Authors: M. Kozakova, C. Morizzo, S. La Carrubba, I. Fabiani, D. Della Latta, J. Jamagidze, D. Chiappino, V. Di Bello, C. Palombo Source Type: research

Adherence to the Mediterranean Diet in Children and Adolescents: A Systematic Review
A decreased adherence to the Mediterranean Diet (MD) may be related to a rise in chronic non-communicable diseases from childhood onward. The aim of this systematic review was to summarize the available literature regarding MD adherence in children and adolescents, and focusing, more specifically, on the association of MD adherence with demographic and anthropometric variables, body composition, lifestyle, and diet adequacy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 14, 2017 Category: Nutrition Authors: P. Iaccarino Idelson, L. Scalfi, G. Valerio Source Type: research

Smoking cessation improves cardiometabolic risk in overweight and obese subjects treated with varenicline and dietary counseling
Weight gain after stopping smoking potentially counteracts improvements in cardiometabolic risks. We investigated changes in metabolic syndrome (MetS) components and homeostasis assessment model insulin resistance (HOMA-IR) in smokers given dietary counseling during their quit attempt. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 4, 2017 Category: Nutrition Authors: E. Heggen, M. Svendsen, S. Tonstad Source Type: research

Calorically Restricted Diets Decrease PCSK9 in Overweight Adolescents
We examined the effects of an intensive nutritional intervention on PCSK9 levels in overweight adolescents with cardiovascular disease (CVD) risk factors. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 3, 2017 Category: Nutrition Authors: A.E. Levenson, C.E. Milliren, S.B. Biddinger, C.B. Ebbeling, H.A. Feldman, D.S. Ludwig, S.D. de Ferranti Source Type: research

Comments on “Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk”
We were interested to read the paper by Bozzetto L and colleagues published in Nutrition, Metabolism& Cardiovascular Diseases in Jul 2016 [1]. The authors aimed to evaluate the association between liver fat content (LF) and metabolic, inflammatory and nutritional factors in a homogeneous cohort of individuals at high cardio-metabolic risk. A multiple stepwise regression analysis was used to determine the effect measure of the associations. The results showed that oral glucose insulin sensitivity (-OGIS), glucagon like peptide-1 (GLP-1), HDL-cholesterol and IFN- γ were best predictors of hepatic/renal echo intensi...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: M. Sani, E. Ayubi Tags: Letters to the Editor Source Type: research

Modulazione dell'omeostasi del colesterolo da parte di Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) nel macrofago
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) è una proteina appartenente alla famiglia delle proproteine convertasi espressa principalmente nel fegato, nell'intestino tenue, nel rene e nel sistema nervoso centrale. La principale funzione di PCSK9 è quella di regolare i livelli circolanti di LDL-C attraverso la degradazione del recettore per le LDL (LDLR) a livello epatico. PCSK9 contribuisce anche alla regolazione di altre funzioni cellulari in tessuti extraepatici come il macrofago del lume vascolare. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: M.P. Adorni, I. Zanotti, E. Cipollari, E. Favari, F. Zimetti, A. Corsini, C. Ricci, F. Bernini, N. Ferri Source Type: research

Clinical and genetic features of 2 patients with severe hypertriglyceridemia due to a mutation in GPIHBP1 gene
Background: Familial chylomicronemia is a recessive disorder that may be due to mutations in ipoprotein lipase (LPL) and in other proteins such as apolipoprotein C-II and apolipoprotein A-V (activators of LPL), GPIHBP1 (the molecular platform required for LPL activity on endothelial surface), and LMF1 (a factor required for intracellular formation of active LPL). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: G.I. Altieri, R. Spina, D. Noto, V. Ingrassia, V. Valenti, A. Giammanco, F. Fayer, G. Misiano, C. Scrimali, A. Ganci, C.M. Barbagallo, A.B. Cefalu', M.R. Averna Source Type: research

Preliminary clinical experience of PCSK9 inhibitors in  patients with heterozygous familial hypercholesterolemia. Considerations on their use in patients on lipoprotein apheresis treatment and in statins intolerant patients
The introduction of monoclonal antibodies anti-PCSK9 as a treatment option in patients with Heterozygous Familial Hypercholesterolemia (HeFH) represents a recent advancement in the pharmacological toolbox currently available to reach the recommended individual LDL-cholesterol (LDL-C) target. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: A. Altomari, V. Sanga, G. Ceradini, A. Fabris, A. Lupo, E. Bonora, M. Dauriz, M.G. Zenti Source Type: research

Evaluation of LP(a) and insulin during pregnancy in not diabetic women. Preliminary data
Aim: Lp(a) is a circulating lipoprotein containing apoB100 covalently bound to apo(a). Lp(a) is a recognized independent risk factor for cardiovascular disease (CVD). However, Lp(a) levels may be found lower in diabetics with respect to the general population. It has been suggested that hyperinsulinemia affects Lp(a) concentrations. We investigate whether any association between insulin and Lp(a) levels during pregnancy we can found in not diabetic women. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: C.O. Aragona, V. Cairo, M. Scuruchi, L. Giunta, F. Mamone, F. Savarino, M. Ardesia, M.A. Sardo, A. Di Benedetto, G. Mandraffino, A. Saitta Source Type: research

Elevated LDL and oxidative stress contribute to arrhythmogenic cardiomyopathy phenotypic manifestation
Arrhythmogenic cardiomyopathy (AC) is characterized by progressive fibro-fatty replacement of the myocardium, arrhythmias and sudden death in young athletes. Due to a desmosomal gene mutation, AC patients present an autosomal-dominant trait of inheritance, with incomplete penetrance and variable expressivity, suggesting the involvement of possible co-factors determining the pathological phenotype. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: L. Arnaboldi, I. Stadiotti, S. De Metrio, S. Brambilla, G. Milano, A. Scopece, F. Cattaneo, A. Granata, A. Corsini, G. Pompilio, C. Tondo, E. Sommariva Source Type: research

Proteomic studies to assess the mechanism of action of the antiproliferative effect of furoxans in smooth muscle cells
Atherosclerosis is characterized by oxidation, altered NO bioavailability and increased smooth muscle cell (SMC) proliferation in vascular intima. To find innovative antiatherosclerotic approaches we synthesized NO-donor molecules (furoxans) able to inhibit SMC proliferation. We demonstrated that the antiproliferative effect of 4-phenyl-furoxans is related to the electron-attractor power of the substituent in position 3 of the aromatic ring. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: L. Arnaboldi, M. Lombardi, M. Sinelli, B. Rolando, L. Lazzarato, R. Fruttero, A. Gasco, A. CorsinI Source Type: research

“Do you take your drug?” Development of an UHPLC-MS/MS method to quantify antihypertensive drugs in human plasma, for the assessment of therapeutic adherence in patients with “resistant” hypertension
Introduction: Nowadays hypertension is becoming increasingly regarded since its prevalence rises with the progressive aging of global population. In a little fraction of hypertensive patients (15-30%) the administration of one or two drugs is not enough to achieve adequate blood pressure values. These cases are defined as “resistant hypertension” (RH) and require at least three antihypertensive drugs. Not-pharmacological treatment, in these cases, consists in invasive surgery (e.g. renal denervation). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: V. Avataneo, A. De Nicol ò, G. Bonifacio, F. Rabbia, E. Perlo, E. Berra, C. Fulcheri, P. Mulatero, F. Veglio, G. Di Perri, A. D'Avolio Source Type: research

Role of PCSK9 (proprotein convertase subtilisin/kexin type 9) beyond LDLR targeting: Focus on glucose metabolism
Background: PCSK9 (proprotein convertase subtilisin/kexin type 9), a 692 –amino acid glycoprotein, came to the attention of the scientific community in 2003, when it was identified as the third gene involved in autosomal dominant hypercholesterolemia, beyond LDLR (low-density lipoprotein receptor) and ApoB (apolipoprotein B). Subsequently, several mutations in PCSK9 ge ne were described, both “gain-of-function” mutations associated to hypercholesterolemia and “loss of function” mutations linked to low levels of circulating LDL-C (LDL cholesterol), suggesting its important role in cholesterol m...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: G. Balzarotti, G. Tibolla, M. Ruscica, M. Stramba-Badiale, A.L. Catapano, G.D. Norata Source Type: research

Effector memory T cells predict atherosclerosis progression and cardiovascular events over 4 years follow-up
Background: Experimental models demonstrate that adaptive T-cell response is promoted during atherogenesis and increased effector memory T subsets have been observed in patients with coronary artery disease. Aim of the study is to see whether expanded circulating T effector memory (TEM) (CD3+CD4+CD45RA −CD45RO+CCR7−) subtypes predict long term atherosclerosis progression and incidence of cardiovascular events in the general population. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: A. Baragetti, K. Garlaschelli, F. Bonacina, L. Grigore, E. Ammirati, A.L. Catapano, G.D. Norata Source Type: research

Disease trends over time and effector memory T-cells predict atherosclerosis development in Systemic Lupus Erythematosus
In this study we aimed at investigating the association of immunoinflammatory disease activity and of classical cardiovascular risk factors (CVRF) with five years atherosclerosis development. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: A. Baragetti, G.A. Ramirez, M. Magnoni, K. Garlaschelli, L. Grigore, M. Berteotti, I. Scotti, E. Bozzolo, A. Berti, A.A. Manfredi, E. Ammirati, A.L. Catapano, G.D. Norata Source Type: research

Effects of a 8-week treatment with monoclonal antibody anti-PCSK9 therapy on platelet function in subjects affected by familial hypercholesterolemia
Introduction: Familial hypercholesterolemia is an important cardiovascular risk factor and lowering low-density lipoprotein (LDL) cholesterol levels reduces the risk of cardiovascular diseases and mortality. Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) plays a major role in the regulation of LDL receptor function by promoting LDL receptor internalization and lysosomal degradation. LDL-lowering therapies with monoclonal antibody PCSK9 inhibitors have shown great efficacy in reducing LDL-cholesterol levels whereas their effects on platelets – cells deeply involved in the pathogenesis of atherothrombosis – are...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: C. Barale, K. Bonomo, F. Noto, M. Traversa, F. Cavalot, M.D. Iozzia, C. Frascaroli, A. Guerrasio, I. Russo Source Type: research

Adherence to Mediterranean Diet and non-alcoholic fatty liver disease: Impact on metabolic profile
Introduction: Many different mechanisms are supposed to play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). NAFLD is strongly associated with obesity and diabetes. Several nutritional approaches have been proposed for NAFLD patients. The Mediterranean Diet (MD) is a dietary pattern with beneficial properties in primary and secondary prevention of cardio-metabolic diseases. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: F. Baratta, D. Pastori, L. Polimeni, I. Ernesti, M. Del Ben, F. Angelico Source Type: research

LDL-cholesterol reduction with PCSK9 inhibitors: A meta-analysis of randomised controlled trials
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease involved in lipid metabolism by mediating LDL receptor (LDLR) clearance through a post-transcriptional mechanism. The inhibition of PCSK9 results in increased expression of the hepatic LDL-R and in a consequent lipid-lowering effect. Since the role of PCSK9 in LDLR degradation and LDL-cholesterol (LDL-c) metabolism was discovered, different pharmacological approaches to inhibit this protein have been developed in a very short time. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: O. Bernocchi, M. Casula, L. Scotti, E. Tragni, G. Corrao, A.L. Catapano Source Type: research

The incidence of cardiovascular events is largely reduced in hyper-Lp(a) patients on lipoprotein apheresis. The G.I.L.A. (gruppo interdisciplinare ldl aferesi) pilot study
Aim: Lipoprotein apheresis (LA) is the elective therapy for homozygous and other forms of Familial Hypercholesterolemia resistant/intolerant to lipid lowering drugs and hyperlipoproteinemia(a). (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: F. Bigazzi, F. Sbrana, D. Berretti, M.G. Zenti, S. Zambon, A. Fabris, M. Fonda, G. D'Alessandri, B. Dal Pino, M. Pianelli, R. Luciani, A. Ripoli, D. Rafanelli, A. Colpo, L. Cattin, T. Sampietro Source Type: research

Genetic diagnosis of familial hypercholesterolaemia: Preliminary data from the university of Padua outpatient lipid clinic
Background: Familial Hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD) due to lifelong elevated plasma low-density lipoprotein (LDL) cholesterol levels. Aims of our study was to define the genotypic features of FH in relation to the clinical phenotype and the severity of the cardiovascular risk profile; assess the potential impact of genotypic characterization on response to drug therapy. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: P. Bigolin, A. Antonucci, R. Marin, D. Vianello, S. Bertocco, L. Previato, F. Fabris, E. Manzato, A. Zambon, S. Zambon Source Type: research

Impaired fatty acid synthesis affects immune cells activation: Focus on sterol regulatory element binding factor-1c on T lymphocytes
Background: Intracellular metabolism has recently been recognized as a key determinant of immune cells differentiation and activation and animal models lacking crucial genes of lipid metabolism are currently used to unraveil their impact on immune responses. Therapeutic targeting of metabolic checkpoint is a new challenge for the treatment of immunometabolic diseases. SREBP1c is one of the three isoforms of the sterol regulatory element-binding proteins, involved in the regulation of fatty acid synthesis. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: F. Bonacina, G. Cermenati, D. Caruso, A.L. Catapano, N. Mitro, G.D. Norata Source Type: research

Increased wave reflection is associated with reduced sleep duration in individuals exposed to aircraft noise pollution
Background: Exposure to environmental noise might exert negative effects on cardiovascular function. Aim of the study is to explore whether chronic stress and/or sleep fragmentation and loss, associated with exposure to aircraft noise, have a detrimental effect on vascular function. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: R.M. Bruno, U. Faraguna, M. Di Pilla, M. Di Galante, T. Banfi, A. Gemignani, G. Licitra, M.A. Vigotti, S. Taddei, L. Ghiadoni Source Type: research

Evaluation of efficacy and safety of Evolocumab 140  mg in genetically characterized He-FH patients. First experience of Genoa lipid clinic
Introduction: Primary objective was to establish how lipid profile is modified in patients affected by Heterozygous Familial Hypercholesterolemia (He-FH) treated with high intensity statin therapy in association to Ezetimibe 10 mg after eight weeks of therapy with Evolocumab, the new antiPCSK9 monoclonal antibody; secondary objective was to verify the tolerability of the product. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: G. Bruzzone, P. Lopena, G. Balleari, P. Dapino, R. Fresa, A. Pende, F. Dallegri, S. Bertolini, L. Pisciotta Source Type: research

Role of microRNA-155 in the pathogenesis and treatment of psoriatic arthritis
Background: MicroRNAs (miRNAs) are small non-coding RNA sequences capable of binding to specific mRNAs by regulating the processes of growth, differentiation and apoptosis. Dysregulation of their function causes altered gene transcription processes and therefore is also precipitating cause of many disease processes. Psoriatic arthritis (AP) is a chronic inflammatory arthropathy the occurrence of which is related to levels of miRNAs “dysregulated” in multiple locations and in various forms. The miRNA-155 (miR-155) is a classic example of multi-functional miRNA responsible for controlling pathological processes t...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: M. Bucci, U. Ianni, E. Celletti, E. Sabatini, D. De Cesare, F. Cipollone Source Type: research

Microbiota composition affects lipid metabolism and intestinal homeostasis
Undernutrition, defined as inadequate intake or assimilation of nutrients, still determines worldwide half of all deaths in children younger than 5 years of age. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: M. Busnelli, S. Manzini, A. Boukadiri, A. Bruneau, C. Philippe, P. G érard, G. Chiesa Source Type: research

Severe carotid atheromatous stenosis regression after subcutaneous administration of tocilizumab
Takayasu arteritis (TA) is a chronic inflammatory disease of unknown etiology that involves large and medium-sized arteries, primarily the aorta and its major branches. TA is a therapeutic challenge because corticosteroids and conventional immunosuppressive agents are not always safe and/or efficacious. Interleukin 6 (IL-6) has emerged as a key cytokine in the pathogenesis of TA and its serum levels have been shown to well correlate with disease activity. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 1, 2017 Category: Nutrition Authors: V. Cairo, A. Lo Gullo, C.O. Aragona, F. Savarino, F. Mamone, M. Scuruchi, M.A. Sardo, E. Imbalzano, M. Cinquegrani, G. Mandraffino, A. Saitta Source Type: research