Effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and cardiovascular disease: A meta-analysis

The impact of the loss-of-function (LOF) genetic variant PCSK9 R46L on glucose homeostasis and cardiovascular disease (CVD) remains uncertain, despite its established correlation with diminished blood cholesterol levels. This meta-analysis aimed at exploring the effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and CVD.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 18, 2024 Category: Nutrition Authors: Sen Liu, Jindong Wan, Dan Wang, Yi Yang, Jie Fang, Tao Luo, Dengpan Liang, Jun Hu, Jixin Hou, Peijian Wang Source Type: research