Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF- β1/ERK pathways
In conclusion, this work hig hlighted a potential therapeutic approach of DAS as a dietary preventive agent against BPH via its anti-inflammatory and immunomodulatory effect along with suppression of the ERK pathway. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

Salt-dependent hypertension and inflammation: targeting the gut –brain axis and the immune system with Brazilian green propolis
AbstractSystemic arterial hypertension (SAH) is a major health problem around the world and its development has been associated with exceeding salt consumption by the modern society. The mechanisms by which salt consumption increase blood pressure (BP) involve several homeostatic systems but many details have not yet been fully elucidated. Evidences accumulated over the last 60 decades raised the involvement of the immune system in the hypertension development and opened a range of possibilities for new therapeutic targets.Green propolis is a promising natural product with potent anti-inflammatory properties acting on spec...
Source: Inflammopharmacology - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

The advances of methotrexate resistance in rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and basic pharmacological research. In several observational studies, MTXR, and treatment responses in RA patients show that the ratio of MTXR and non- response is about 30% –50%, namely MTX resistance (MTXR). Extensive efforts have been made into the investigation of the mechanism and effective biomar...
Source: Inflammopharmacology - August 5, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Evaluation of in vivo anti-inflammatory and anti-angiogenic attributes of methanolic extract of Launaea spinosa
Unfortunately, a section under the heading “Materials and Method” has been published with errors. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 3, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of combined colchicine-corticosteroid treatment on neutrophil/lymphocyte ratio: a predictive marker in Beh çet disease activity
ConclusionCollectively our results suggest that the NLR is a potential marker of BD activity in Algerian patients, predicting the disease severity. Moreover, the positive relationship between the NLR and NO production is related to an increased risk of mucocutaneous lesions and vascular involvement. Thus, the application of these two accessible tools could be benefit for the clinical prognosis and treatment of BD. (Source: Inflammopharmacology)
Source: Inflammopharmacology - July 16, 2020 Category: Drugs & Pharmacology Source Type: research

Marine sponges Sarcotragus foetidus , Xestospongia carbonaria and Spongia obscura constituents ameliorate IL-1 β and IL-6 in lipopolysaccharide-induced RAW 264.7 macrophages and carrageenan-induced oedema in rats
In this study, whole methanol extracts and fractionated compounds from three marine sponges namelyXestospongia carbonaria,Sarcotragus foetidus andSpongia obscura were thoroughly investigated for their antibacterial, antifungal, antioxidant and anti-inflammatory activities. Methanol extracts and fractionated compounds were characterised using high performance liquid chromatography –mass spectrometry and gas chromatography–mass spectrometry. Extracts were checked for cytotoxicity in RAW macrophages by MTT assay, before using them for the treatment study. Enzyme linked immunosorbent assay kits were used to check t...
Source: Inflammopharmacology - July 16, 2020 Category: Drugs & Pharmacology Source Type: research

Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C
AbstractGreen propolis is a resinous substance used in folk medicine given its anti-inflammatory, antibacterial, and anti-ulcer effects. Our research group has already confirmed the gastroprotective activity of hydroalcoholic extract from green propolis (HEGP), as well as of its main isolated compounds. In continuity, this study evaluated the antioxidant mode of action involved in the preventive effect induced by HEGP, and its therapeutic gastric healing potential on installed ulcers. In addition, the healing effect of its main compound Artepillin C was also investigated. Acute and chronic ulcers were induced in rats by gi...
Source: Inflammopharmacology - July 16, 2020 Category: Drugs & Pharmacology Source Type: research

Reduced cutaneous inflammation associated with antioxidant action after topical application of the aqueous extract of Annona muricata leaves
This study investigated the effect of the aqueous extract ofA. muricata leaves (AEAM) on TPA-induced ear inflammation and antioxidant capacity, both in vitro and in vivo. The in vitro antioxidant capacity of AEAM was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP) and lipoperoxidation assays. Cytotoxicity and reactive oxygen species (ROS) release were evaluated in the L929 fibroblasts. Swiss mice were submitted to TPA application and were topically treated with AEAM (0.3, 1 or 3  mg/ear). After 6 h, inflammatory and oxidative parameters were evaluated. Quercetin 3-gl...
Source: Inflammopharmacology - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

A viral infection explanation for Kawasaki disease in general and for COVID-19 virus-related Kawasaki disease symptoms
AbstractSARS-CoV-2, a new virus that appeared in Wuhan, China, in 2019 has approximately an 80% genomic match to the Severe Acute Respiratory Symptom (SARS) virus, which is known to come from a bat virus. Symptoms of Kawasaki disease in general and incomplete Kawasaki disease have been seen in a subset of pediatric patients having a current or previous infection of SARS-CoV-2. A viral infection, such as a SARS-CoV-2 virus infection, could result in extensive antigen –antibody immune complexes that cannot be quickly cleared in a subset of patients and thus create a type III hypersensitivity immune reaction and cause K...
Source: Inflammopharmacology - July 7, 2020 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory effect of stevioside abates Freund ’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
AbstractAdjuvant arthritis is a chronic, autoimmune and inflammatory disorder of the joints. The occurrence of disorder causes a severe damage to the connective tissue eventually leading to progressive physical disability and eventual death. The recent years of evidence suggests the anti-inflammatory properties of stevioside, a diterpene glycoside. However, the effect of stevioside against adjuvant arthritis, a chronic inflammatory disorder is not known. Hence, the present study was designed to study the effect of stevioside against Freund's complete adjuvant induced arthritis model in rats. The acute anti-inflammatory eff...
Source: Inflammopharmacology - July 2, 2020 Category: Drugs & Pharmacology Source Type: research

Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation
AbstractThe therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternatives in this scenario. GenusUvaria is a part of Annonaceae family, while the majority of its species are widely distributed in tropical rain forest regions of South East Asia.Uvaria species have been used extensively used as traditional medicine for treating all sorts of inflammatory diseases including...
Source: Inflammopharmacology - July 2, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia –reperfusion through attenuating endoplasmic reticulum stress
Unfortunately, Fig. 5 was incorrectly published in the original publication. The complete corrected Fig. 5 is given below. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 29, 2020 Category: Drugs & Pharmacology Source Type: research

Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation
In this study, we aimed to confirm whether activation of the NLRP3 inflammasome in the spinal cord was involved in the development of neuropathic pain and whether PF could be an effective treatment for this type of pain. We found that activation of the NLRP3 inflammasome mediated the development of neuropathic pain following chronic constriction injury of the sciatic nerve and that PF attenuated neuropathic pain by inhibiting NLRP3 inflammasome activation. Moreover, PF enhanced the translocation of the transcription factor nuclear factor erythroid 2-related factor 2 into the nucleus and suppressed nuclear factor-kappa B ac...
Source: Inflammopharmacology - June 28, 2020 Category: Drugs & Pharmacology Source Type: research

Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats
In conclusion, we reveal that the combination of metformin with MCC950 has a protective role in DSS-induced colitis and might become a candidate in a promising approach for the future treatment of human UC. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 27, 2020 Category: Drugs & Pharmacology Source Type: research

Accelerated ageing profile in inflammatory arthritis is unique and tissue compartment specific
AbstractRheumatoid arthritis is prevalent in more than 1% of the global population, with the highest occurrence between ages 35 and 50, which places a huge burden on the economy. Drug discovery for the prevention of this chronic disease is; therefore, a priority. It is known that subclinical progression of many chronic non-communicable diseases is exacerbated via accelerated ageing, a pro-inflammatory phenotype shift. However, rheumatoid arthritis additionally has significant humoral immune activation, inflammatory signalling —and thus the accelerated ageing profile—may differ from other chronic inflammatory di...
Source: Inflammopharmacology - June 27, 2020 Category: Drugs & Pharmacology Source Type: research

Oral administration of Centella asiatica (L.) Urb leave aqueous extract ameliorates cerebral oxidative stress, inflammation, and apoptosis in male rats with type-2 diabetes
Conclusions:C. asiatica treatment helps to prevent cerebral damage and maintain near normal cerebral function in diabetes. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 25, 2020 Category: Drugs & Pharmacology Source Type: research

Empagliflozin suppresses inflammation and protects against acute septic renal injury
ConclusionOverall, the findings of this study suggest that empagliflozin could be repurposed to reduce morbidity and mortality in patients with acute septic renal injury.Trial registrationNot applicable. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 20, 2020 Category: Drugs & Pharmacology Source Type: research

Antinociceptive effect of Lonchocarpus araripensis lectin: activation of l -arginine/NO/cGMP/K + ATP signaling pathway
ConclusionThe antinociceptive effect ofLonchocarpus araripensis lectin involves activation of thel-arginine/NO/GMPc/K+ATP pathway. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 15, 2020 Category: Drugs & Pharmacology Source Type: research

Retraction Note: Selected TLR7/8 agonist and  type I interferon (IFN‑α) cooperatively redefine the microglia transcriptome
Since publication, it has become apparent that there are major errors in the qRT-PCR data presented. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 15, 2020 Category: Drugs & Pharmacology Source Type: research

Design, synthesis and pharmacological assessment of new pyrazole compounds
This study investigated the antinociceptive and anti-inflammatory effects of new pyrazole compounds LQFM011(5), LQFM043(6) and LQFM044(7) as well as the mechanisms of action and acute in vitro toxicity.Main methodsThe antinociceptive activity was evaluated using the acetic acid-induced abdominal writhing test, formalin-induced pain test and the Randall –Selitto test. The anti-inflammatory activity was evaluated using models of paw oedema and pleurisy induced by carrageenan; cell migration, the levels of tumour necrosis factor α (TNF-α) and myeloperoxidase (MPO) enzyme activity were evaluated. In addition,...
Source: Inflammopharmacology - June 11, 2020 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress
ConclusionIn the present study, milnacipran showed anti-nociceptive and anti-inflammatory effects on carrageenan-induced hyperalgesia and inflammation in a dose-dependent manner. Milnacipran reduced inflammatory edema and increased the paw withdrawal threshold probably through suppression of MDA, NO, TNF- α, IL-1β, IL-6 and MPO activity, and increase of TAC status in the hind paw tissue. Therefore, milnacipran holds important potential as an anti-inflammatory and anti-nociceptive drug. Although, further clinical trials to confirm this issue, is required. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 9, 2020 Category: Drugs & Pharmacology Source Type: research

Preoperative meloxicam versus postoperative meloxicam for pain control, patients ’ satisfaction and function recovery in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study
In conclusion, preoperative meloxicam achieves better efficacy and similar tolerance c ompared to postoperative meloxicam in hip OA patients post THA. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 6, 2020 Category: Drugs & Pharmacology Source Type: research

The protective effect of Sophora japonica on prostatic hypertrophy and inflammation in rat
In conclusion, SFE has an ameliorating effect on the prostatic hypertrophy and inflammation. T his effect may be attributed to the ability of SFE to decrease the production of pro-inflammatory cytokines, TNF-α, IL-1β and IGF-1 as well as an increase in TGF-β1. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 5, 2020 Category: Drugs & Pharmacology Source Type: research

LP44 (4-[2-(methylthio)phenyl]- N -(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor  7 activation on indomethacin-induced gastric ulcers in rats
ConclusionThe study suggested that activation of 5-HT7 receptor showed a significant anti-ulcerogenic effect in the indomethacin-induced gastric ulcer model. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 5, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Special Section : “Commemorating Leading Inflammo-Pharmacologists”
(Source: Inflammopharmacology)
Source: Inflammopharmacology - June 3, 2020 Category: Drugs & Pharmacology Source Type: research

Central nervous system evaluation of an ethanol extract of Bidens odorata Cav (Asteraceae) leaves, and its antinociceptive interaction with paracetamol and naproxen
ConclusionBOE induces sedative and anticonvulsant effects. The anxiolytic actions shown by BOE are probably induced by the participation of the GABAergic system. BOE exerts antinociceptive synergistic interaction with paracetamol and naproxen probably by the participation of nitric oxide and ATP-sensitive K+ channels, respectively. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 1, 2020 Category: Drugs & Pharmacology Source Type: research

Perindopril ameliorates experimental Alzheimer ’s disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling
AbstractAccumulating evidence indicates that over-stimulation of angiotensin-converting enzyme 1 (ACE1) activity is associated with β-amyloid (Aβ) and phosphorylated tau (p-tau)-induced apoptosis, oxido-nitrosative neuroinflammatory stress and neurodegeneration in Alzheimer’s disease (AD). Alternatively, activation of the ACE2, the metalloprotease neprilysin (Neutral Endopeptidase; NEP) and the insulin-degrading enzyme (IDE) could oppose the effects of ACE1 activation. We aim to investigate the relationship between ACE1/ACE2/NEP/IDE and amyloidogenic/hyperlipidemic-lipid raft signaling in hyperlipidemic AD ...
Source: Inflammopharmacology - June 1, 2020 Category: Drugs & Pharmacology Source Type: research

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated T H 17/T reg balance
AbstractImmunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (TH17) cells and regulatory T  cells (Treg cells) is involved in ulcerative colitis (UC) pathogenesis. Dendritic cells (DCs) are able to induce T  cell differentiation. Paeoniflorin (PF) is a monoterpene glucoside that is commonly used for treatment of autoimmune disease. However, the immunological mechanism of PF involvement in UC treatment is unclear. The present study aimed to explore whether PF can restore the TH17/Treg balance by modulating DCs. The effects of PF on D...
Source: Inflammopharmacology - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway
Abstractischaemic stroke accounts for almost 11% of all deaths worldwide and has a high incidence of permanent disability among patients. Baicalein has many beneficial pharmacological properties, including anti-inflammatory and anti-oxidant effects. However, the neuroprotective effect of baicalein is still unclear. The current study scrutinizes the neuroprotective effect of baicalein against the ischaemic/reperfusion (I/R) injury via alteration of the nuclear factor kappa B (NF-kB) and AMP-activated protein kinase/nuclear factor erythroid 2-related factor 2 AMPK/Nrf2 signaling pathway. Wistar rats were used for the current...
Source: Inflammopharmacology - May 16, 2020 Category: Drugs & Pharmacology Source Type: research

Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage –adipocyte interaction
AbstractMethyl 3,4,5-trimethoxycinnamate (MTC) is a bioactive natural phenylpropanoid. We evaluated anti-inflammatory effects of synthetic MTC in RAW264.7 macrophages and RAW264.7 –3T3-L1 adipocytes co-culture. Levels of cytokines and chemokines, as well as NO and PGE2 in cell supernatants  were analysed using ELISAs, Griess assay and enzyme immunoassays, respectively. In-cell cytoblot was used to assess levels of proteins; while DNA binding and reporter gene assays were used to measure transcription factor DNA binding and transcriptional activities, respectively. Glucose uptake in a dipocytes was evaluated with...
Source: Inflammopharmacology - May 16, 2020 Category: Drugs & Pharmacology Source Type: research

Prophylactic effect of resveratrol and piperine on pristane-induced murine model of lupus-like disease
AbstractSystemic lupus erythematosus is a multisystem autoimmune disease. Apart from usual treatments, approximately 50% of lupus patients use complementary medicine. Resveratrol is a phytoalexin with various pharmacological properties. We hypothesised that prophylactic treatment with resveratrol may abrogate manifestations in pristane-induced murine model of lupus-like disease and piperine; a bio-enhancer of resveratrol may enhance these properties. The prophylactic effect of resveratrol (25  mg/kg body weight: P-Res) alone and in combination with piperine (2.5 mg/kg body weight: P-RP) were assessed. P-Res and P...
Source: Inflammopharmacology - May 15, 2020 Category: Drugs & Pharmacology Source Type: research

Methanolic extract of Ephedra ciliata promotes wound healing and arrests inflammatory cascade in vivo through downregulation of TNF- α
AbstractChronic wounds may lead to the development of various pathological conditions such as diabetic foot ulcers and pressure sores. The current study evaluated wound healing and anti-inflammatory potentials of methanolic extract ofEphedra ciliata using series of in vivo models. Methanolic extract ofEphedra ciliata was prepared by maceration (Ec.Me). Qualitative and quantitative (HPLC) phytochemical and metal analyses were conducted to explore the chemical and metal profiles ofEc.Me. Safety profile (behavioural)  and, antimicrobial, antioxidant, wound healing, anti-inflammatory and anti-angiogenic potentials ofEc.Me...
Source: Inflammopharmacology - May 8, 2020 Category: Drugs & Pharmacology Source Type: research

APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNF α expression and signalling
AbstractNeutrophils are key players in the pathophysiological process underlying inflammatory conditions not only by release of tissue-damaging cytotoxic enzymes, reactive oxygen species (ROS) but also by secretion of important immunomodulatory chemokines and cytokines. Here, we report the effects of the novel agent APPA, undergoing formal clinical development for treatment of osteoarthritis, and its constituent components, apocynin (AP) and paeonol (PA) on a number of neutrophil functions, including effects on TNF α- expression and signalling. Neutrophils were treated with APPA (10–1000 µg/mL) prior...
Source: Inflammopharmacology - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

Lapatinib inhibits doxorubicin induced migration of HER2-positive breast cancer cells
In this study, we report the effectiveness of Lap in the suppression of low-dose response to doxorubicin (Dox) in HER2-positive SKBR3 cells. Upon treatment of SKBR3 cells with 0.1  µM of Dox, the cell viability was significantly increased as compared to the human mammary fibroblasts, and triple-negative human breast cancer MDA-MB-231 cells. Interestingly, the effect of 0.1 µM Dox revealed morphological changes consistent with a significant increase in the formation of pro minent F-actin filaments and mitochondrial spread compared with the control SKBR3 cells. Furthermore, an enhanced migration was als...
Source: Inflammopharmacology - May 6, 2020 Category: Drugs & Pharmacology Source Type: research

Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process
This study was undertaken to identify the effects of tannic acid (TA), a naturally occurring dietary polyphenol, in a mouse model of PF. Bleomycin (BLM) was intratracheally administered to induce PF. Administration of TA significantly reduced BLM-induced histological alterations, inflammatory cell infiltration and the levels of various inflammatory mediators (nitric oxide, leukotriene  B4 and cytokines). Additionally, treatment with TA also impaired BLM-mediated increases in pro-fibrotic (transforming growth factor- β1) and fibrotic markers (alpha-smooth muscle actin, vimentin, collagen 1 alpha and fibr...
Source: Inflammopharmacology - May 5, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Appraisal of  disease-modifying potential of amlodipine as an anti-arthritic agent: new indication for an old drug
Unfortunately, the 4th author name was incorrectly published in the original publication. (Source: Inflammopharmacology)
Source: Inflammopharmacology - May 2, 2020 Category: Drugs & Pharmacology Source Type: research

Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF- кB inflammatory signalling
AbstractGentianella acuta (G.  acuta), as a folk medicine, was used to treat heart disease by the Ewenki people in Inner Mongolia. However, the effect ofG.  acuta on acute myocardial infarction (AMI) is not clear. To explore the mechanisms ofG.  acuta on isoproterenol (ISO)-induced AMI, rats were administeredG.  acuta for 28  days, then injected intraperitoneally with ISO (85 mg/kg) on days 29 and 30. An electrocardiogram helped to evaluate the myocardial injury. Serum lactate dehydrogenase (LDH), creatinine kinase (CK) and aspartate aminotransferase (AST) levels were evaluated, and haematoxyl...
Source: Inflammopharmacology - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

New synthetic coumarinolignans as attenuators of pro-inflammatory cytokines in LPS-induced sepsis and carrageenan-induced paw oedema models
ConclusionAll four SCLs, especially compound2, have shown vast potential to emerge out as promising anti-inflammatory drugs. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 30, 2020 Category: Drugs & Pharmacology Source Type: research

Metformin ameliorates animal models of dermatitis
AbstractMetformin, a potent AMPK activator is the most commonly used drug for diabetes. According to recent reports, metformin lowers the risk of diabetic complications and inflammatory diseases. We found the expression levels of AMPK subunits includingPRKAA1,PRKAA2,PRKAB1 andPRKAB2 are decreased in skin biopsies of dermatitis patients from multiple datasets. Interestingly, metformin treatment ameliorates dermatitis symptom in animal model of dermatitis usingO-tetradecanoylphorbol-13-acetate (TPA). Especially, the levels of epidermis and dermis thickness were decreased by metformin. We found NF κB activity as well as...
Source: Inflammopharmacology - April 28, 2020 Category: Drugs & Pharmacology Source Type: research

Cellular mechanisms and molecular signaling pathways in stress-induced anxiety, depression, and blood –brain barrier inflammation and leakage
AbstractDepression and anxiety are comorbid conditions in many neurological or psychopathological disorders. Stress is an underlying event that triggers development of anxiety and depressive-like behaviors. Recent experimental data indicate that anxiety and depressive-like behaviors occurring as a result of stressful situations can cause blood –brain barrier (BBB) dysfunction, which is characterized by inflammation and leakage. However, the underlying mechanisms are not completely understood. This paper sought to review recent experimental preclinical and clinical data that suggest possible molecular mechanisms invol...
Source: Inflammopharmacology - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

Antinociceptive and anti-inflammatory effects of Cuphea aequipetala Cav (Lythraceae)
In conclusion, CAE induced antinociceptive effects without affecting motor coordination, probably due to the involvement of nitric oxide and ATP-sensitive K+ channels. CAE also exerts in vitro and in vivo anti-inflammatory effects by increasing the release of IL-10. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus
AbstractInflammation and angiogenesis are two major contributors to tumourigenesis.Melilotus indicus is traditionally used as an anti-inflammatory agent. The current study was designed to investigate the anti-inflammatory and anti-angiogenic properties of ethanolic extract ofM. indicus (Miet) whole plant and its marker compound (coumarin) using a series of in vivo methods. Extraction by maceration was adopted to prepare ethanolic extract. Phytochemical compounds present inMiet were investigated using both qualitative and quantitative methods. In vivo safety profile ofMiet was investigated in behavioural studies. Four acute...
Source: Inflammopharmacology - April 15, 2020 Category: Drugs & Pharmacology Source Type: research

Neuroprotective and anti-inflammatory activity of DAT inhibitor R -phenylpiracetam in experimental models of inflammation in male mice
AbstractR-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently,R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the dopaminergic system is associated with persistent neuroinflammation, the aim of this study was to determine whetherR-PhP, an inhibitor of DAT, has neuroprotective and anti-inflammatory effects in male mice. The pharmacokinetic profiles of  R-PhP  in mouse plasma and its bioavailability in brain...
Source: Inflammopharmacology - April 11, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats
AbstractPaclitaxel use in cancer treatment is limited by a painful syndrome that has no effective treatment. Despite new therapies, drugs of the World Health Organization (WHO) analgesic ladder remain a useful therapeutic tool for cancer pain relief. Since cancer pain is caused by both tumor and chemotherapy, we assessed the efficacy of drugs from the WHO analgesic ladder for cancer pain relief in a paclitaxel-induced pain syndrome (P-IPS) model. P-IPS was induced in rats by one or four injections of paclitaxel on alternate days. The acute and chronic phases were assessed 24  h and 15 days after the first paclita...
Source: Inflammopharmacology - April 7, 2020 Category: Drugs & Pharmacology Source Type: research

Deferoxamine regulates neuroinflammation and oxidative stress in rats with diabetes-induced cognitive dysfunction
AbstractDiabetic encephalopathy, a major complication of diabetes, is characterized by cognitive impairment and structural and neurochemical abnormalities. Neuroinflammation following impairment of iron homeostasis is a remarkable feature of several neurological disorders. In the present study, we investigated the role of deferoxamine (DFO), as a clinical iron chelator, in improvement of type 1 diabetes-induced cognitive dysfunction. Streptozotocin was utilized to induce type 1 diabetic in rat model. Animals were categorized into four groups: control, diabetic, diabetic  + Iron and diabetic + DF...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

Combinatorial therapeutic effect of resveratrol and piperine on murine model of systemic lupus erythematosus
This study aimed to evaluate the combinatorial effect of resveratrol (25  mg/kg and 50 mg/kg) and its bio-enhancer piperine (1/10th dose of resveratrol) on pristane-induced SLE murine model. Mice were injected with 0.5 ml of pristane and after 2 months they were orally dosed with resveratrol combinations for 4 months. Determined by indirect immunofluorescence, resve ratrol was unable to abrogate autoantibody formation. The increased IFN-α, IL-6 and TNF-α was mitigated by low dose of resveratrol and piperine (RP-1). None of the doses regulated the increase in nitric oxide. Lipogranulomas...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

Analysis of lncRNA expression profiles by sequencing reveals that lnc-AL928768.3 and lnc-AC091493.1 are novel biomarkers for disease risk and activity of rheumatoid arthritis
This study aimed to analyze long non-coding RNA (lncRNA) expression profiles in synovium tissue of patients with RA using RNA sequencing, and to further assess the clinical values of dysregulated lncRNAs in RA diagnosis and monitoring.MethodsThirty patients with RA who underwent knee arthroscopy and 30 controls with knee trauma who underwent surgery were consecutively enrolled and synovium tissue samples of both groups were obtained during surgery. In the exploration stage, lncRNA and mRNA expression profiles in three RA samples and three control samples were detected by RNA sequencing and bioinformatic analyses were then ...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

Investigating the route of administration and efficacy of adipose tissue-derived mesenchymal stem cells and conditioned medium in type 1 diabetic mice
AbstractType 1 diabetes (T1D) is a chronic autoimmune disease destroying the insulin-producing beta cells. Recently, stem cell therapy has been tested to treat T1D. In the present study, we aim to investigate the effects of intraperitoneal and intravenous infusion of multipotent mesenchymal stem/stromal cells (MSCs) and MSC-conditioned medium (MSC-CM) in an experimental model of diabetes, induced by multiple injections of Streptozotocin (STZ). The adipose tissue-derived MSC and MSC-CM were isolated from C57Bl/6 male mice and characterized. Later, MSC and MSC-CM were injected intraperitoneally or intravenously into mice. Th...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

The inflammatory effect of epigenetic factors and modifications in type 2 diabetes
AbstractInflammation has a central role in the etiology of type 2 diabetes (T2D) and its complications. Both genetic and epigenetic factors have been implicated in the development of T2D-associated inflammation. Epigenetic mechanisms regulate the function of several components of the immune system. Diabetic conditions trigger aberrant epigenetic alterations that contribute to the progression of insulin resistance and β-cell dysfunction by induction of inflammatory responses. Thus, targeting epigenetic factors and modifications, as one of the underlying causes of inflammation, could lead to the development of novel imm...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research

Clindamycin inhibits nociceptive response by reducing tumor necrosis factor- α and CXCL-1 production and activating opioidergic mechanisms
AbstractClindamycin, a bacteriostatic semisynthetic lincosamide, is useful in the management of infections caused by aerobic and anaerobic Gram-positive cocci, including bacteremic pneumonia, streptococcal toxic shock syndrome and sepsis. It has been recently demonstrated that clindamycin inhibits in vitro and in vivo inflammatory cytokine production. In the present study, we investigated the effects of clindamycin in acute and chronic models of pain and inflammation in mice and the underlying mechanisms. Intraperitoneal (i.p.) administration of clindamycin (400  mg/kg) increased the animal’s latency to exhibit ...
Source: Inflammopharmacology - March 24, 2020 Category: Drugs & Pharmacology Source Type: research