Statin Use and Risk of Diabetes by Subclinical Atherosclerosis Burden (from a Multi-Ethnic Study of Atherosclerosis Report)
Although there is a significant reduction in atherosclerotic cardiovascular disease risk with statins, a higher risk of diabetes mellitus has been demonstrated in randomized clinical trials. The risk of incident diabetes with statins may be heterogeneous by presence of coronary artery calcium (CAC). We evaluated participants without prevalent diabetes at baseline from the MESA (Multi-Ethnic Study of Atherosclerosis), a prospective cohort study of subjects free of clinical cardiovascular disease at baseline. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 1, 2022 Category: Cardiology Authors: Mahmoud Al Rifai, Moyses Szklo, Jaideep Patel, Michael J. Blaha, Christie M. Ballantyne, Vera Bittner, Pamela Morris, John W. McEvoy, Michael D. Shapiro, Mouaz H. Al-Mallah, Philip Greenland, Salim S. Virani Source Type: research

Feasibility of Sentinel Cerebral Embolic Protection Device Deployment During Transfemoral Transcatheter Aortic Valve Replacement
Cerebral embolic protection has emerged as a preventive measure for procedural stroke in transcatheter aortic valve replacement (TAVR).1 The Sentinel System (Boston Scientific Corp. Boston, Massachusetts), a 2-filter debris-capturing system, has been the only commercially available protection device in the United States since its approval by the Food and Drug Administration in 2017. In the Sentinel trial, the largest randomized trial (n  = 363) so far, the device was successfully deployed in 94.7% of patients. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 1, 2022 Category: Cardiology Authors: Toshiaki Isogai, Husitha Reddy Vanguru, Amar Krishnaswamy, Ankit Agrawal, Nikolaos Spilias, Shashank Shekhar, Anas M. Saad, Beni Rai Verma, Rishi Puri, Grant W. Reed, Zoran B. Popovi ć, Shinya Unai, James J. Yun, Ken Uchino, Samir R. Kapadia Source Type: research

Prediction of Sudden Cardiac Arrest After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: ASA-SCARRE Risk Score
This study aimed to derive a new score, the Alcohol Septal Ablation-Sudden Cardiac ARREst (ASA-SCARRE) risk score, that can be easily used to evaluate the risk of sudden cardiac arrest events (sudden cardiac death, resuscitation, or appropriate implantable cardioverter-defibrillator discharge) after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy. We analyzed 1,834 patients from the Euro-ASA registry (49% men, mean age 57 ± 14 years) who were followed up for 5.0 ± 4.3 years (9,202 patient-years) after ASA. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 30, 2022 Category: Cardiology Authors: Josef Veselka, Max Liebregts, Robert Cooper, Lothar Faber, Jaroslav Januska, Maksim Kashtanov, Klara Hulikova Tesarkova, Peter Riis Hansen, Hubert Seggewiss, Eugene Shloydo, Kirill Popov, Eva Hansvenclova, Eva Polakova, Jurri ën ten Berg, Rodney Hilton S Source Type: research

Noninvasive Assessment of Left Ventricular Pressure-Volume Relations: Inter- and Intraobserver Variability and Assessment Across Heart Failure Subtypes
A novel method to derive pressure-volume (PV) loops noninvasively from cardiac magnetic resonance images has recently been developed. The aim of this study was to evaluate inter- and intraobserver variability of hemodynamic parameters obtained from noninvasive PV loops in healthy controls, subclinical diastolic dysfunction (SDD), and patients with heart failure with preserved ejection fraction, mildly reduced ejection fraction, and reduced ejection fraction. We included 75 subjects, of whom 15 were healthy controls, 15 subjects with SDD (defined as fulfilling 1 to 2 echocardiographic criteria for diastolic dysfunction), an...
Source: The American Journal of Cardiology - September 30, 2022 Category: Cardiology Authors: Jonathan Edlund, Per M. Arvidsson, Anders Nelsson, J. Gustav Smith, Martin Magnusson, Einar Heiberg, Katarina Steding-Ehrenborg, H åkan Arheden Source Type: research

Circumferential Fibrosis of the Ascending Aorta After COVID Infection
After recovering from severe COVID-19 infection, 2 women presented with chest pain. Computed tomographic angiography suggested acute ascending aortic dissection. At operation in both patients, the ascending aorta was encased in dense fibrous tissue, within which were focal collections of mononuclear cells, including many plasma cells. There was no entry tear or dissection. Such findings we have not encountered previously, and PubMed search of “periaortic fibrosis and COVID-19” yielded no similar cases or possible relation. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 29, 2022 Category: Cardiology Authors: Charles S. Roberts, William C. Roberts Source Type: research

Comparative Effectiveness and Safety of Cryoablation Versus Radiofrequency Ablation Treatments for Persistent Atrial Fibrillation
The purpose of this study was to compare the effectiveness and safety of 2 strategies for catheter treatment of patients with persistent atrial fibrillation in the long-term period, using cardiac implantable loop recorders. The research is a prospective, randomized, controlled study designed to compare the results of modern catheter technologies in patients with persistent atrial fibrillation. The study included 127 patients with persistent atrial fibrillation in the last 6  months before inclusion in the study, for whom at least 2 antiarrhythmic drugs of class I to III were not effective. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 29, 2022 Category: Cardiology Authors: Adil K. Baimbetov, Kenzhebek A. Bizhanov, Aiman M. Jukenova, Aigul T. Aubakirova, Aliya Ye. Ualiyeva, Inkar Ye. Sagatov Source Type: research

Effectiveness and Safety Profile of Remote Pulmonary Artery Hemodynamic Monitoring in a “Real-World” Veterans Affairs Healthcare System
Ambulatory hemodynamic monitoring has demonstrated the ability to reduce heart failure-related hospitalization, regardless of left ventricular ejection fraction; however, real-world data in a Veterans Affairs patient population are limited. The present study retrospectively reviewed 53 patients with New York Heart Association class III heart failure, regardless of left ventricular ejection fraction, implanted with a pulmonary artery pressure sensor (CardioMEMS) at our single Veterans Affairs institution. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 29, 2022 Category: Cardiology Authors: Gregory Paul Milligan, Nicole Minniefield, Bharath Raju, Nishi Patel, Katherine Michelis, Johanna Van Zyl, Daniel Cheeran, Amit Alam Source Type: research

Meta-Analysis Comparing Clinical Outcomes of Fractional-Flow-Reserve- and Angiography-Guided Multivessel Percutaneous Coronary Intervention
Fractional flow reserve (FFR) to guide percutaneous coronary intervention (PCI) for intermediate coronary stenosis in the setting of multivessel coronary artery disease (CAD) is recommended by the latest 2022 American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions guideline (class of recommendation I, level of evidence A).1 This recommendation is predominantly derived from the landmark Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) trial. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 29, 2022 Category: Cardiology Authors: Connor Jack Matthews, Kate Naylor, Jonathan Mark Blaxill, John Pierre Greenwood, Abdul Moheet Mozid, Jennifer Ann Rossington, Murugapathy Veerasamy, Stephen Bentley Wheatcroft, Heerajnarain Bulluck Source Type: research

Aortic Intimal-Medial Tear Without Dissection, the Marfan Syndrome, and Its Forme Fruste Variety
Acute aortic dissection is a relatively common disease involving the aorta. All aortic dissections start with an intimal-medial tear prior to the medial dissection. Several cases of aortic intimal-medial tear without dissection have been reported previously, but only one article presented a photograph of the intimal-medial tear. Herein, we describe 16 patients whose ascending aortas were operatively excised because of what clinically was believed to be acute aortic dissection. Of the 16 patients, 14 had aortic intimal-medial tears without dissection and the other 2 had acute medial dissection of the aorta adjacent to a hea...
Source: The American Journal of Cardiology - September 28, 2022 Category: Cardiology Authors: William C. Roberts, Minseob Jeong, Charles S. Roberts Source Type: research

Comparison of Outcomes in Patients With Atrial Fibrillation Under Oral Anticoagulation Therapy Analyzed by Body Weight ( < 60, 60 to 100, and > 100 kg)
This study aimed to evaluate embolic, hemorrhagic, and mortality events in anticoagulated patients, administered both antivitamin K and direct oral anticoagulants based on the body weight (100  kg). A retrospective registry-based cohort study including all consecutive patients with a diagnosis of atrial fibrillation between January 2014 and January 2018 in the health area of Vigo (Galicia, Spain) was used (CardioCHUVI‐AF registry; ClinicalTrials.gov identifier: NCT04364516). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 26, 2022 Category: Cardiology Authors: Pablo Dom ínguez-Erquicia, Sergio Raposeiras-Roubín, Emad Abu-Assi, Paula Bouzon-Iglesias, Jose A. Parada-Barcia, Andrea Lizancos-Castro, André González-García, Vanesa A. Noriega-Caro, Ana Ledo-Piñeiro, Carla Iglesias-Otero, Inmaculada González-Ber Source Type: research

Estimated Atherosclerotic Cardiovascular Disease Risk: Disparities and Severe COVID-19 Outcomes (from the National COVID Cohort Collaborative)
We examined the relation of the pooled-cohort ASCVD risk score to severe COVID-19 among 28,646 subjects from the National COVID Cohort Collaborative database who had positive SARS-CoV-2 test results from April 1, 2020 to April 1, 2021. In addition, 10-year ASCVD risk scores were calculated, and subjects were stratified into low-risk ( (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 26, 2022 Category: Cardiology Authors: Yousif A. Arif, Alexa M. Stefanko, Nicholas Garcia, David A. Beshai, Wenjun Fan, Nathan D. Wong Source Type: research

Rehospitalization of Patients with Advanced Heart Failure Receiving Continuous, Palliative Dobutamine or Milrinone
This study aims to determine the incidence of all-cause hospitalization in patients with advanced heart failure (AHF) receiving ambulatory continuous, intravenous dobutamine versus milrinone for palliative intent. Despite medical optimization, patients with AHF develop refractory symptoms, resulting in frequent hospitalizations. Previous trials precede modern care standards. Data regarding inotrope choice in palliation are limited. This retrospective analysis included 222 patients with AHF and reduced left ventricular ejection fraction discharged on palliative dobutamine (n  = 135) or milrinone (n = 87). (Source: The A...
Source: The American Journal of Cardiology - September 24, 2022 Category: Cardiology Authors: Rachael E. Eaton, Kevin T. Kissling, Garrie J. Haas, Eric M. McLaughlin, Kerry K. Pickworth Source Type: research

Pulmonary Embolism Readmission Trend Over the Years (from a National Readmission Database)
As more sensitive laboratory testing and imaging studies emerge, more pulmonary embolism (PE) cases are being detected over the years.1 However, despite the increase in incidence, mortality has decreased from 7.1% in 1993 to 3.2% in 2012.1 With the increased detection and prevalence of PE, it is becoming more important to consider the posthospital clinical course of patients with PE. With the Hospital Readmissions Reduction Program implemented by the Centers for Medicare and Medicaid Services, hospitals now need to reduce 30-day unplanned readmission rates after 6 conditions or specific procedures, to avoid penalizations. ...
Source: The American Journal of Cardiology - September 24, 2022 Category: Cardiology Authors: Mukunthan Murthi, Sujitha Velagapudi, Dae Yong Park, Hafeez Shaka Source Type: research

Anatomical and Clinical Factors Associated With Valvulopathy and Aortopathy in Mexican Patients With Bicuspid Aortic Valves
The bicuspid aortic valve (BAV) is associated with significant aortic valve dysfunction. We aimed to study Mexican patients with BAV to assess phenotypic expressions of BAV, and associations of valvulopathy and aortopathy and their predictors. A cross-sectional, retrospective study was designed. The patients were divided according to (1) normally or minimally dysfunctional BAV, (2) predominant aortic regurgitation (AR), and (3) predominant aortic stenosis (AS). A total of 189 patients were included with a high prevalence of males (68%). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 24, 2022 Category: Cardiology Authors: Nydia Avila-Vanzzini, Lourdes Medina-Paz, Enrique Berrios-B árcenas, Antonio Arias-Godínez, Jesús Díaz-Marín, Hector Herrera-Bello, Alma Amaya-Gómez, Javier Mancilla-Galindo, Hector I. Michelena Source Type: research

Ambulatory Pulmonary Artery Pressures After Transcatheter Edge-to-Edge Repair of the Mitral Valve in Patients With Heart Failure and Mitral Regurgitation
The objective of this study was to assess ambulatory hemodynamics after transcatheter edge-to-edge repair (TEER) of the mitral valve. Pulmonary artery pressure (PAP) measurements from implanted sensors were collected through a remote monitoring database and linked to Medicare fee-for-service claims data. Among patients with linked data, those undergoing TEER were included if the ambulatory PAP monitor was implanted ≥3 months before TEER and ≥3 months of PAP data after TEER were available. The primary end point was diastolic PAP (dPAP) at 3 months after TEER compared with baseline. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - September 24, 2022 Category: Cardiology Authors: David M. Shavelle, Thomas J. Heywood, Ajay V. Srivastava, Rahul Agarwal, Julie B. Prillinger, Gregory J. Roberts, Joseph K. Yu, Matthew J. Price Source Type: research