Patient-Reported Outcomes in Adults With Congenital Heart Disease Following Hospitalization (From APPROACH-IS)
In this international study, we (i) compared patient-reported outcomes (PROs) in adults with congenital heart disease (CHD) who had vs. had not been hospitalized during the previous 12 month, (ii) contrasted PROs in patients who had been hospitalized for cardiac surgery vs. non-surgical reasons, (iii) assessed the magnitude of differences between the groups (i.e. effect sizes), and (iv) explored differential effect sizes between countries. APPROACH-IS was a cross-sectional, observational study that enrolled 4,028 patients from 15 countries (median age 32y; 53% females). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 15, 2021 Category: Cardiology Authors: Philip Moons, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke A. Sluman, Jou-Kou Wang, Jamie L. Jackson, Paul Khairy, Stephen C. Cook, Shanthi Chidambarathanu, Luis Alday, Erwin Oechslin, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Source Type: research

Standardized Measurement of Femoral Artery Depth by Computed Tomography to Predict Vascular Complications after Transcather Aortic Valve Implantation
Vascular complications (VCs) are difficult to predict and remain an important issue after transfemoral (TF) transcatheter aortic valve implantation (TAVI) although their incidence has decreased with size reduction of introducers. We aimed to evaluate a standardized measurement of femoral artery depth (FAD) using computed tomography (CT) to predict VCs after TAVI. We performed a retrospective study of 679 TF TAVI patients. We evaluated a standardized CT method to measure FAD immediately above the bifurcation. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 15, 2021 Category: Cardiology Authors: Eric Durand, Maryline Penso, Thibault Hemery, Thomas Levesque, Gustavo Moles, Christophe Tron, Najime Bouhzam, Nicolas Bettinger, Stephanie Wong, Jean-Nicolas Dacher, H élène Eltchaninoff Source Type: research

In-hospital Outcomes and Trends of Endovascular Intervention vs Surgical Revascularization in Octogenarians with Peripheral Artery Disease
It is unknown whether endovascular intervention (EVI) is associated with superior outcomes when compared with surgical revascularization in octogenarian. National Inpatient Sample (NIS) database was used to compare the outcomes of limb revascularization in octogenarians who had surgical revascularization versus EVI. The NIS database's information on PAD patients ≥80-year-old who underwent limb revascularization between 2002 to 2014 included 394,504 octogenarian patients, of which 184,926 underwent surgical revascularization (46.9%) and 209,578 underwent EVI (53.1%). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 15, 2021 Category: Cardiology Authors: Homam Moussa Pacha, Yasser Al-khadra, Fahed Darmoch, Mohamad Soud, Chun Shing Kwok, Mamas A. Mamas, Said Ashraf, Yasar Sattar, Waqas Ullah, Subhash Banerjee, Salman A. Arain, Dmitriy N. Feldman, Mazen Abu-Fadel, Herbert D. Aronow, Mehdi H. Shishehbor, M C Source Type: research

“The Tragedy of Low Interest Rates”
Interest rates in the U.S. will remain artificially and abnormally low for the foreseeable future, likely for at least the next 5 years, and probably longer. You will hear a variety of reasons proposed, including to support the economy and create jobs after the COVID crisis, boost the stock market, encourage affordable housing, and whatever else. But the real reason is to bail out debtors, the largest of which is the U.S. government. The end result of the suppression of interest rates by the central banks represents a transfer of wealth from thrifty savers like you, to profligate, undisciplined spenders, allowing them to l...
Source: The American Journal of Cardiology - January 15, 2021 Category: Cardiology Authors: Robert M. Doroghazi Source Type: research

Meta-analysis of Transcatheter Aortic Valve Implantation in Patients with Stenotic Bicuspid vs. Tricuspid Aortic Valve
Transcatheter aortic valve implantation (TAVI) is currently approved for the treatment of tricuspid aortic stenosis (TAS) in patients with high, intermediate, and even low risk for surgery .1 Most trials investigating the role of TAVI across various strata of risk categories have excluded patients with bicuspid aortic stenosis (BAS) due to its anatomical complexities. There is a ∼20% prevalence of BAS in patients greater than 80 years of age .2 Elderly patients with BAS represent an unique therapeutic challenge in high risk and intermediate risk strata where surgery is not feasible. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Monil Majmundar, Ashish Kumar, Rajkumar Doshi, Palak Shah, Shilpkumar Arora, Mariam Shariff, Devina Adalja, Ferdinand Visco, Hossam Amin, Saraschandra Vallabhajosyula, Nageshwara Gullapalli, Samir R. Kapadia, Ankur Kalra, Sidakpal S. Panaich Tags: Original article Source Type: research

Pericardial Involvement in Cancer
Despite the monumental advances in the diagnoses and therapeutics of malignancy, several cancer patients have presented with pericardial involvement, including acute pericarditis, constrictive pericarditis, and pericardial effusion.Multiple factors can contribute to acute pericarditis, including direct metastasis to the heart, pericardial hemorrhage, infections due to immunosuppression, and cancer therapies that include chemotherapy, immunotherapy, and radiation. Pericardial effusion, either due to cancer invasion or cancer treatment, is one of the most common incidental findings in cancer patients, which significantly wor...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Johnny Chahine, Shashank Shekhar, Gauranga Mahalwar, Massimo Imazio, Patrick Collier, Allan Klein Source Type: research

Relation of First and Total Recurrent Atherosclerotic Cardiovascular Disease Events to Increased Lipoprotein(a) Levels among Statin Treated Adults with Cardiovascular Disease
We examined first and total recurrent ASCVD event risk in statin-treated adults with prior ASCVD. We studied 3,359 adults (mean age 63.6 years, 85.1% male) with prior ASCVD on statin therapy from the AIM-HIGH clinical trial cohort. The first and total ASCVD event rates were calculated by lipoprotein(a) [Lp(a)] categories. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Nathan D. Wong, Yanglu Zhao, Jennifer Sung, Auris Browne Source Type: research

Comparison of Hospitalization Trends and Outcomes in Acute Myocardial Infarction Patients with versus without Opioid Use Disorder
Discrepancies in medical care are well known to adversely affect patients with opioid abuse disorders (OUD), including management and outcomes of acute myocardial infarction (AMI) in patients with OUD. We used the National Inpatient Sample was queried from Jan 2006 to Sept 2015 to identify all patients ≥18years admitted with a primary diagnosis of AMI (weighted N=13,030; unweighted N=2670) and concomitant OUD. Patients using other non-opiate illicit drugs were excluded. Propensity matching (1:1) yielded well matched 2253 pairs among which intergroup comparison of invasive revascularization strat egies and cardiac outcom...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Sagar Ranka, Tarun Dalia, Prakash Acharya, Siva Sagar Taduru, Suveenkrishna Pothuru, Uzair Mahmood, Brianna Stack, Zubair Shah, Kamal Gupta Source Type: research

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Graftinge Among Patients with Unprotected Left Main Coronary Artery Disease in the New-Generation Drug-Eluting Stents Era (From the CREDO-Kyoto PCI/CABG Registry Cohort-3)
Long-term safety of percutaneous coronary intervention (PCI) as compared with coronary artery bypass grafting (CABG) is still controversial in patients with unprotected left main coronary artery disease (ULMCAD), and there is a scarcity of real-world data on the comparative long-term clinical outcomes between PCI and CABG for ULMCAD in new-generation drug-eluting stents (DES) era. The CREDO-Kyoto PCI/CABG registry Cohort-3 enrolled 14927 consecutive patients undergoing first coronary revascularization with PCI or isolated CABG between January 2011 and December 2013, and we identified 855 patients with ULMCAD (PCI: N=383 [4...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Ko Yamamoto, Hiroki Shiomi, Takeshi Morimoto, Kazushige Kadota, Tomohisa Tada, Yasuaki Takeji, Yukiko Matsumura-Nakano, Yusuke Yoshikawa, Kazuaki Imada, Takenori Domei, Kazuhisa Kaneda, Ryoji Taniguchi, Natsuhiko Ehara, Ryuzo Nawada, Masahiro Natsuaki, Ky Source Type: research

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With versus Without Chronic Kidney Disease
Chronic kidney disease (CKD) might be an important determinant in choosing percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). However, there is a scarcity of studies evaluating the effect of CKD on long-term outcomes after PCI relative to CABG in the population including severe CKD. Among 30257 consecutive patients undergoing first coronary revascularization with PCI or isolated CABG in the CREDO-Kyoto PCI/CABG registry Cohort-2 (N=15330) and Cohort-3 (N=14927), we identified the current study population of 12878 patients with multivessel or left main disease, and compared long-term clinic...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Ko Yamamoto, Masahiro Natsuaki, Takeshi Morimoto, Hiroki Shiomi, Yasuaki Takeji, Kazushige Kadota, Kazuaki Imada, Mamoru Toyofuku, Naoki Kanemitsu, Eiji Shinoda, Satoru Suwa, Atsushi Iwakura, Toshihiro Tamura, Yoshiharu Soga, Tsukasa Inada, Mitsuo Matsuda Source Type: research

Supravalvular Aortic Stenosis and the Risk of Premature Death among Patients with Homozygous Familial Hypercholesterolemia
Patients with homozygous familial hypercholesterolemia (HoFH) have a high risk for premature death. Supravalvular aortic stenosis (SVAS) is a common and the feature lesion of the aortic root in HoFH. The relationship between SVAS and the risk of premature death among patients with HoFH has not been fully investigated. The current study analysis included 97 HoFH patients with mean age of 14.7 (years) from the Genetic and Imaging of Familial Hypercholesterolemia in Han Nationality Study. During the median ( ±SD) follow-up 4.0 (±4.0) years, 40 (41.2%) participants had SVAS and 17(17.5%) participants experienced ...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Ruiying Zhang, Jinjie Xie, Jie Zhou, Liyuan Xu, Yufan Pan, Yichen Qu, Rongjuan Li, Mei Chong, Li Song, Wenhui Wen, Yue Wu, Jialu Li, Luya Wang, Ya Yang Source Type: research

Effect of Mitral Regurgitation on Thrombotic Risk in Patients with Nonrheumatic Atrial Fibrillation: a New CHA2DS2-VASc Score Risk Modifier?
Atrial fibrillation (AF) significantly increases the risk of ischemic stroke (IS), but the risk varies strongly depending on the individual patient's stroke risk factors.1 Many scores, such as the CHA2DS2-VASc score, have been developed to guide physicians in their decision to start anticoagulation.2 However, the risk prediction with these models is modest at best (C-statistic  = 0.6).3,4 Severe mitral regurgitation (MR) has been shown to decrease left atrial (LA) thrombus formation and systemic thromboembolic (TE) events in AF patients with rheumatic valve disease with an observed risk reduction of more than 50%. (Sou...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Sven L. Van Laer, Seppe Verreyen, Koen M. Winkler, Hielko Miljoen, Andrea Sarkozy, Hilde Heuten, Johan Saenen, Paul Van Herck, Caroline M. Van de Heyning, Hein Heidbuchel, Marc J. Claeys Source Type: research

Early Initiation of Feeding and In-hospital Outcomes in Patients Hospitalized for Acute Heart Failure
Extensive data on early nutrition support for patients requiring critical care are available. However, whether early initiation of feeding could be beneficial for patients hospitalized for acute heart failure (HF) remains unclear. We sought to compare outcomes of early and delayed initiation of feeding for hospitalized patients with acute HF using a nationwide inpatient database. We retrospectively analyzed data from the Diagnosis Procedure Combination database. We included patients hospitalized for HF between January 2010 and March 2018. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Hidehiro Kaneko, Hidetaka Itoh, Kojiro Morita, Tadafumi Sugimoto, Masaaki Konishi, Kentaro Kamiya, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Hideo Yasunaga, Issei Komuro Source Type: research

Center-Level Variations in Maximum Recipient Body Mass Index in Heart Transplantation
This study explored center-level variations in maximum recipient body mass index (BMI) and the associated impact of morbid obesity on outcomes of orthotopic heart transplantation (OHT). Using the United Network for Organ Sharing (UNOS) database, we examined adults ( ≥18 years) undergoing OHT between 2010-2018. Centers performing (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Bryant W Fisher, Lauren V Huckaby, Ibrahim Sultan, Gavin Hickey, Arman Kilic Source Type: research

Transcatheter Aortic Valve Implantation During the COVID-19 Pandemic
Transcatheter aortic valve implantation (TAVI) outcomes during the coronavirus disease 2019 (COVID-19) pandemic have not been fully evaluated and some structural programs in the world have been suspended during this period. We sought to evaluate and compare clinical outcomes in patients undergoing TAVI in pandemic vs non-pandemic era. In a single center, we compared 198 TAVI patients performed during 2019 to 59 patients performed during the COVID-19 pandemic period (March 1st to June 30th, 2020). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Mart ín Valdebenito, Eias Massalha, Israel M. Barbash, Elad Maor, Paul Fefer, Victor Guetta, Amit Segev Source Type: research

Meta-Analysis Comparing the Safety and Efficacy of Single vs. Dual Antiplatelet Therapy in Post Transcatheter Aortic Valve Implantation Patients.
The relative safety and efficacy of aspirin versus dual antiplatelet therapy (DAPT; aspirin+clopidogrel) in patients who underwent transcatheter aortic valve implantation (TAVI) and did not have a long-term indication for oral anticoagulation remains controversial. Digital databases were searched to identify relevant articles. The major safety endpoint was bleeding, while the efficacy endpoints included post-TAVI ischemic and thrombotic events. Data were analyzed using a random effect model to calculate the pooled unadjusted odds ratio (OR) for dichotomous outcomes. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Waqas Ullah, Mohamed Zghouzi, Bachar Ahmad, Suman Biswas, Nathan Zaher, Yasar Sattar, Homam Moussa Pacha, Andrew M. Goldsweig, Poonam Velagapudi, David L. Fichman, Anand Prasad, M. Chadi Alraies Source Type: research

Arrhythmogenic Right Ventricular Cardiomyopathy Presenting as Clinical Myocarditis in Women
Myocarditis is a non-specific inflammatory disease of the myocardium with varied presentation and etiology1-3. Given limitations of endomyocardial biopsy, the diagnosis is often based on clinical presentation and cardiac magnetic resonance (CMR) imaging3-6. There is increasing evidence that underlying genetic abnormalities associated with cardiomyopathy may predispose patients to myocarditis7-10. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is classically associated with myocyte loss due to disruption of the cardiac desmosomes, leading to fibrofatty replacement and an arrhythmic presentation11-14. (Source: The Am...
Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Paul J Scheel, Brittney Murray, Crystal Tichnell, Cynthia A James, Harikrishna Tandri, Hugh Calkins, Stephen P Chelko, Nisha A Gilotra Source Type: research

Incidence, Predictors, and Outcomes of Thrombotic Events in Hospitalized Patients With Viral Pneumonia
Viral pneumonia represents a major cause of morbidity and mortality, especially among older patients.1 Viral pneumonia may be associated with a systemic inflammatory response, which has been linked with arterial and venous thrombotic cardiovascular events.2 During the recent COVID-19 pandemic due to the novel SARS-CoV-2 virus, anecdotal and published experience suggests high rates of thrombotic complications among hospitalized patients.3 Due to a paucity of studies describing the incidence, predictors, and outcomes of thrombotic events among patients with viral pneumonia, the observation of thrombosis in patients with COVI...
Source: The American Journal of Cardiology - January 13, 2021 Category: Cardiology Authors: Islam Y. Elgendy, Dhaval Kolte, Michael K. Mansour, Rahul Sakhuja, Sammy Elmariah, Farouc A. Jaffer, Tomas G Neilan, James L. Januzzi, Ido Weinberg, Mazen S. Albaghdadi Source Type: research

Closing Gaps in Lifestyle Adherence for Secondary Prevention of Coronary Heart Disease
The secondary prevention (SP) of coronary heart disease (CHD) has become a major public health and economic burden worldwide. In the U.S., the prevalence of CHD has risen to 18 million, the incidence of recurrent myocardial infarctions (MI) remains high, and related healthcare costs are projected to double by 2035. In the last decade, practice guidelines and performance measures for the SP of CHD have increasingly emphasized evidence-based lifestyle (LS) interventions, including healthy dietary patterns, regular exercise, smoking cessation, weight management, depression screening, and enrollment in cardiac rehabilitation (...
Source: The American Journal of Cardiology - January 13, 2021 Category: Cardiology Authors: Monica Aggarwal, Dean Ornish, Richard Josephson, Todd M. Brown, Robert J. Ostfeld, Neil Gordon, Shivank Madan, Kathleen Allen, Aditya Khetan, Ahmed Mahmoud, Andrew M. Freeman, Karen Aspry Source Type: research

Comparison of Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Among Patients with Three-Vessel Coronary Artery Disease in the New-Generation Drug-Eluting Stents Era (From CREDO-Kyoto PCI/CABG Registry Cohort-3)
There is a scarcity of data comparing long-term clinical outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with three-vessel coronary artery disease (3VD) in the new-generation drug-eluting stents era. CREDO-Kyoto PCI/CABG registry Cohort-3 enrolled 14927 consecutive patients who had undergone first coronary revascularization with PCI or isolated CABG between January 2011 and December 2013. We identified 2525 patients with 3VD (PCI: N=1747 [69%], and CABG: N=778 [31%]). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 13, 2021 Category: Cardiology Authors: Yukiko Matsumura-Nakano, Hiroki Shiomi, Takeshi Morimoto, Kyohei Yamaji, Natsuhiko Ehara, Hiroki Sakamoto, Yasuaki Takeji, Yusuke Yoshikawa, Ko Yamamoto, Kazuaki Imada, Takeshi Tada, Ryoji Taniguchi, Ryusuke Nishikawa, Tomohisa Tada, Takashi Uegaito, Tats Source Type: research

Transcatheter Aortic Valve Implantation Outcomes in Chronic Kidney Disease versus End-Stage Kidney Disease
Patients with end stage kidney disease on dialysis (ESKD-D) have a high risk of developing aortic stenosis (AS). The dystrophic calcification of the aortic annulus and leaflets occurs with worsening renal function, leading to an onset 10 to 20 years earlier than the general population, as well as faster progression1. Similarly, patients with less advanced chronic kidney disease (CKD) have been associated with increased postoperative mortality after cardiac procedures2. There is little data to answer the question of whether TAVI is a safe in dialysis patients as they were excluded from the large trials and small trials offe...
Source: The American Journal of Cardiology - January 13, 2021 Category: Cardiology Authors: Abdelrahman I. Abushouk, Omar M. Abdelfattah, Mohamed Hassanein, Anas M. Saad, Navya Vipparla, Toshiaki Isogai, Mohamed M. Gad, Georges Nakhoul, Amar Krishnaswamy, Samir Kapadia Source Type: research

Trends and Outcomes of Transcatheter Valve Implantation in Patients with Prior Mediastinal Radiation
Transcatheter aortic valve implantation (TAVI) is a safe and effective alternative for patients with severe aortic stenosis (AS) irrespective of their surgical risk.1, 2 Aortic stenosis is the most common radiation-induced valvular heart disease. Surgical aortic valve replacement is associated with higher operative mortality and morbidity among patients with prior mediastinal radiation. 3 While a percutaneous approach appears appealing for patients with prior mediastinal radiation, these patients were excluded from pivotal randomized trials. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 13, 2021 Category: Cardiology Authors: Ayman Elbadawi, Islam Y. Elgendy, Aiham Albaeni, Ahmed Sobhy, Ahmad Almustafa, Hend I. Shahin, Arka Chatterjee, Mohamad Alkhouli, Wissam Khalife, Samir Kapadia, Hani Jneid Source Type: research

Utility of Exercise-Induced ST-Segment Elevation in Lead aVR for Detecting Left Main or Proximal Left Anterior Descending Disease
ST-segment changes during exercise stress testing are suggestive of underlying myocardial ischemia and possible coronary artery disease (CAD). Recent studies suggest that exercise-induced ST-elevation (STE) in lead aVR may be associated with significant stenosis of the left main (LM) or proximal left anterior descending (pLAD) arteries1-6. We sought to perform a systematic review and metanalysis of existing literature to evaluate the diagnostic accuracy of exercise-induced STE in lead aVR for the diagnosis of significant LM or pLAD disease. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 13, 2021 Category: Cardiology Authors: Vardhmaan Jain, Subrat Das, Kirtipal Bhatia, Devika Aggarwal, Agam Bansal, Bharat Narasimhan, Nirupama Krishnamurthi, Lily Martin, Aditya Joshi, Arman Qamar, Samir Kapadia, Nina Kukar Source Type: research

Editorial Board
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 6, 2021 Category: Cardiology Source Type: research

Contents
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 6, 2021 Category: Cardiology Source Type: research

Comparison of Outcomes Among Patients with Cardiogenic Shock Admitted on Weekends versus Weekdays
Cardiogenic shock (CS) is associated with high mortality and often requires involvement of a multidisciplinary provider team to deliver timely care. Care coordination is more difficult on weekends, which may lead to a delay in care. We sought to assess the effect of weekend admissions on outcomes in patients admitted with CS. Patients admitted with CS were identified from 2005-2014 in the National Inpatient Sample using ICD9 code 785.51. Baseline demographics, in-hospital procedures, and outcomes were obtained and compared by day of admission. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Ahmed A. Harhash, Kevin F. Kennedy, Timothy J. Fendler, Taiyeb M. Khumri, Michael E. Nassif, Anthony Magalski, Brett W. Sperry Source Type: research

Meta-analysis of Drug-Coated Balloons Versus Drug-Eluting Stents for Small Vessel De-Novo Coronary Artery Disease
Drug coated balloons (DCB) are innovative tools for the management of coronary artery disease1. They have been recognized as an effective treatment strategy for treating both bare metal and drug-eluting stents (DES) restenosis (class 1A level of evidence)1. Several randomized clinical trials (RCTs) assessed the safety and efficacy of DCB versus drug-eluting stents (DES) for the treatment of small vessel [defined as (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Mohamed M.G. Mohamed, Maryam Saleem, Babikir Kheiri, Mohammed Osman Source Type: research

Prevalence of In-hospital Stroke Comparing MitraClip and Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) and mitraclip (MC) are increasingly utilized for the treatment of aortic stenosis (AS) and mitral regurgitation (MR), respectively. Perioperative stroke is one of the most serious complications following TAVI given the valve calcification and possible embolization during valve implantation, and thus ongoing trials are assessing the use of embolic protection device following TAVI. On the other hand, no such trials are being conducted on MC as the evidence of stroke following MC is lacking and MC does not share the same etiology with TAVI 1. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Anas M. Saad, Keerat Rai Ahuja, Omar M. Abdelfattah, Mohamed M. Gad, Toshiaki Isogai, Manpreet Kaur, Grant W. Reed, James Yun, Amar Krishnaswamy, Samir R. Kapadia Source Type: research

Meta-analysis of the Effect of Aspirin on Mortality in COVID-19
Repurposing of existing medications has widely been used in studies since the emergence of coronavirus disease 2019 (COVID-19). Besides dexamethasone in selected patients,1 no medical treatment to date has been shown to improve mortality in patients with COVID-19 infection. Aspirin is associated with reduced mortality and lower risk of acute respiratory distress syndrome (ARDS) in critically ill patients without COVID-19.2, 3 While the exact mechanism behind this effect remains unclear, possible protective effects of aspirin may be related to its anti-thrombotic, anti-inflammatory, and immuno-modulation effects. (Source: T...
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Husam M. Salah, Jawahar L. Mehta Tags: Correspondence Source Type: research

High birth prevalence of congenital heart diseases in conjoined twins and higher order multiple births
The birth prevalence of congenital heart disease (CHD) in the general population is 8 in 1,000 live births. In the United states, twins and triplets occur in approximately 1 in 80 and 1 in 8,000 pregnancies, respectively.1,2 Congenital heart defects are more common in twins than in singletons, and there is an increased occurrence in monochorionic twins compared to dichorionic twins.3-5 There is limited information on the prevalence of CHD in conjoined twins and no information on higher-order multiple births. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Laxmi V Ghimire, Fu-Sheng Chou, Anita J. Moon-Grady Source Type: research

Comparison of the Efficacy and Safety of Sacubitril/Valsartan versus Ramipril in Patients with ST-Segment Elevation Myocardial Infarction
The role of sacubitril/valsartan in patient with heart failure (HF) is established. Whether sacubitril/valsartan plays a role in improving outcomes in patients after ST-segment elevation myocardial infarction (STEMI) is unknown. The current study aims to comparing the efficacy and safety of sacubitril/valsartan versus ramipril in post-STEMI patients. Patients presenting with STEMI were randomized to receive either sacubitril/valsartan or ramipril after primary percutaneous coronary intervention (PCI). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Ahmed Rezq, Marwan Saad, Mostafa El Nozahi Source Type: research

Incidence, Management, Immediate and Long-Term Outcome of Guidewire and Device Related Grade III Coronary Perforations (From G3CAP - Cardiogroup VI registry)
Ellis grade III coronary artery perforations (G3-CAP) remain a life-threatening complication of PCI, with high morbidity and mortality and lack of consensus regarding optimal treatment strategies. We reviewed all PCIs performed in 10 European centers from 1993 to 2019 recording all G3CAP along with management strategies, in-hospital and long-term outcome according to Device-related (DP) and Guidewire-related (WP) perforations. Among 106,592 PCI (including 7,773 chronic total occlusions (CTO)), G3-CAP occurred in 311 patients (0.29%). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 30, 2020 Category: Cardiology Authors: Enrico Cerrato, Marco Pavani, Umberto Barbero, Francesco Colombo, Antonio Mangieri, Nicola Ryan, Giorgio Quadri, Francesco Tomassini, Davide Giacomo Presutti, Simone Calcagno, Alfonso Franz è, Barbara Bellini, Fabrizio D'Ascenzo, Alfonso Ielasi, Michele Source Type: research

Trends in Microbiology Data and Association with Mortality in Infective Endocarditis (2002-2017)
In this study we aim to look at the trends of causative organisms of IE in the US and their association with outcomes. We used the National Inpatient Sample (NIS) data from year 2002 to 20172. International Classification of Diseases (ICD)-9 and ICD-10 codes were used to identify all hospitalizations with IE and age> 18 years. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 30, 2020 Category: Cardiology Authors: Muhammad Zia Khan, Muhammad U Khan, Moinuddin Syed, Sudarshan Balla Source Type: research

Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (from a Nationwide Dataset)
The temporal trends and preprocedural predictors of emergency coronary artery bypass graft surgery (ECABG) after elective percutaneous coronary intervention (PCI) in the contemporary era are largely unknown. From January 2003 to December 2014 elective hospitalizations with PCI as the primary procedure were extracted from the Nationwide Inpatient Sample. ECABG was identified as CABG within 24 hours of elective PCI. Temporal trends of elective PCI, ECABG, comorbidities, and in-hospital mortality were analyzed. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Samir B. Pancholy, Gaurav A. Patel, Neil R. Patel, Dhara D. Patel, Purveshkumar Patel, Stuti M. Pandya, Anshul A. Verma, Sanjay C. Shah, Mamas A. Mamas, Tejas M. Patel Source Type: research

Erratum to ’Relation Between Mitral Valve Prolapse and Erectile Dysfunction (from a Nationwide Case-Control Study)’
The publisher regrets (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Shiu-Dong Chung, Ju-Chi Liu, Tsai-Ning Lou, Ben-Chang Shia, Herng-Ching Lin, Li-Ting Kao Source Type: research

Relation of Bariatric Surgery to Inpatient Cardiovascular Outcomes (From the National Inpatient Sample)
Approximately one in three individuals in the United States are obese. There is a strong association between obesity and an increased rate of cardiovascular disease (CVD)-related mortality. Bariatric surgery (BS) has emerged as an effective strategy to achieve reduction of excess weight. Our study aims to explore the relationship between BS and major adverse cardiovascular events (MACE) among obese hospitalized patients in the United States. This is a retrospective study of all obese adult patients with BMI ≥35 kg/m2 (n= 1,700,943) in the National Inpatient Sample between 2012 to 2016. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Tran Nguyen, Talal Alzahrani, Ari Mandler, Mohammad Alarfaj, Gurusher Panjrath, Joseph Krepp Source Type: research

Impact of Baseline Right Bundle Branch Block on Outcomes after Pulmonary Vein Isolation in Patients with Atrial Fibrillation
Right bundle branch block (RBBB) is one of the most frequent alterations of the electrocardiogram. Several studies have shown that RBBB is a risk factor of cardiovascular diseases. However, the clinical outcomes after pulmonary vein isolation (PVI) in patients with RBBB remain unclear. We enrolled consecutive atrial fibrillation (AF) patients who underwent PVI from the Osaka Rosai Atrial Fibrillation (ORAF) registry. We excluded patients with other wide QRS morphologies (left bundle branch block, ventricular pacing, and unclassified intraventricular conduction disturbances) and divided them into two groups: RBBB (QRS durat...
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Masamichi Yano, Yasuyuki Egami, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Yutaka Matsuhiro, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Akihiro Tanaka, Yasuharu Matsunaga-Lee, Ryu Shutta, Masami Nishino, Jun Tanouchi Source Type: research

Usefulness of Post -Procedural Plasma Brain Natriuretic Peptide Levels to Predict Recurrence After Catheter Ablation of Atrial Fibrillation in Patients with Left Ventricular Systolic Dysfunction
Catheter ablation (CA) has become an established rhythm control therapy in patients with atrial fibrillation (AF) (1), but the long-term freedom from arrhythmic events remains a challenge in some patients. Finding the predictors of AF recurrence is of major importance. Brain natriuretic peptide (BNP) is one of the biomarkers that predicts recurrence after CA of AF (2-6). Although a recent meta-analysis confirmed the association, it also revealed that the predictive value was significantly heterogeneous between studies, possibly due to differences in the study populations (6). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Masato Okada, Nobuaki Tanaka, Koji Tanaka, Yuko Hirao, Issei Yoshimoto, Shinichi Harada, Toshinari Onishi, Yasushi Koyama, Atsunori Okamura, Katsuomi Iwakura, Kenshi Fujii, Yasushi Sakata, Koichi Inoue Source Type: research

Comparison of Characteristics and Outcomes of Patients with Acute Myocardial Infarction with versus without Coronarvirus-19
The coronavirus disease 2019 (COVID-19) pandemic has greatly impacted the US healthcare system. Cardiac involvement in COVID-19 is common and manifested by troponin and natriuretic peptide elevation and tends to have a worse prognosis. We analyzed patients who presented to the MedStar Health system (11 hospitals in Washington, DC, and Maryland) with either an ST-elevation myocardial infarction (STEMI) or non-ST-elevation myocardial infarction (NSTEMI) early in the pandemic (March 1, 2020 – June 30, 2020) using the International Classification of Diseases, Tenth Revision. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Brian C. Case, Charan Yerasi, Brian J. Forrestal, Corey Shea, Hank Rappaport, Giorgio A. Medranda, Cheng Zhang, Lowell F. Satler, Itsik Ben-Dor, Hayder Hashim, Toby Rogers, Ron Waksman Source Type: research

Trends, Outcomes and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention (From a Nationwide Dataset)
The temporal trends and preprocedural predictors of emergency coronary artery bypass graft surgery (ECABG) after elective percutaneous coronary intervention (PCI) in the contemporary era are largely unknown. From January 2003 to December 2014 elective hospitalizations with PCI as the primary procedure were extracted from the Nationwide Inpatient Sample. ECABG was identified as CABG within 24 hours of elective PCI. Temporal trends of elective PCI, ECABG, comorbidities, and in-hospital mortality were analyzed. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Samir B. Pancholy, Gaurav A. Patel, Neil R. Patel, Dhara D. Patel, Purveshkumar Patel, Stuti M. Pandya, Anshul A. Verma, Sanjay C. Shah, Mamas A. Mamas, Tejas M. Patel Source Type: research

Effectiveness and Safety of Extracorporeal Shockwave Myocardial Revascularization in Patients with Refractory Angina Pectoris and Heart Failure
Extracorporeal shockwave myocardial revascularization (ESMR) is a therapy for refractory angina pectoris. Our aim was to assess the efficacy and safety of ESMR in the management of patients with stable coronary artery disease (CAD) and heart failure (HF) as well as its effects on inflammation and angiogenesis. In this single-arm prospective trial we included 48 patients with CAD, myocardial ischemia assessed by radionuclide imaging, echocardiographic evidence of left ventricular systolic dysfunction and without revascularization options. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Carlos Mart ínez-Sánchez, Francisco Azar-Manzur, Héctor González-Pacheco, Luis M Amezcua-Guerra, Felipe Massó, Ricardo Márquez-Velasco, Rafael Bojalil, Isabel Carvajal-Juárez, Erick Alexanderson-Rosas, Salvador Hernández, Araceli Paez-Arenas, Enri Source Type: research

Prevalence and Determinants of Atrial Fibrillation-associated In-hospital Ischemic Stroke in patients with Acute Myocardial Infarction undergoing Percutaneous Coronary Intervention
Atrial Fibrillation (AF) is an established risk factor ischemic stroke (IS) and is commonly encountered in patient hospitalized with acute myocardial infarction (AMI). Uncommonly, IS can occur as a complication resulting from percutaneous coronary intervention (PCI). There is limited real world data regarding AF-associated in-hospital IS (IH-IS) in patients admitted with AMI undergoing PCI. We queried the National Inpatient Sample database from January 2010 to December 2014 to identify patients admitted with AMI who underwent PCI. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Shivaraj Patil, Karthik Gonuguntla, Chaitanya Rojulpote, Manish Kumar, Srinivas Nadadur, Robert J. Nardino, Christopher Pickett Source Type: research

Relation of Body Mass Index to Adverse Right Ventricular Mechanics
This study aimed to investigate the independent effect of increased BMI on RVLS in a large sample of the general population without overt cardiac disease. We examined 1,085 participants (603 men, mean age 62 years) who voluntarily underwent an extensive cardiovascular health check-up. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Koki Nakanishi, Masao Daimon, Yuriko Yoshida, Jumpei Ishiwata, Naoko Sawada, Megumi Hirokawa, Hidehiro Kaneko, Tomoko Nakao, Yoshiko Mizuno, Hiroyuki Morita, Marco R. Di Tullio, Shunichi Homma, Issei Komuro Source Type: research

Comparison of Survival in Patients with Clinically Significant Tricuspid Regurgitation with and without Heart Failure (From the Optum Integrated File)
This study aimed to quantify survival rates for patients with Tricuspid Regurgitation (TR) using real-world data. Several clinical conditions are associated with tricuspid regurgitation (TR), including heart failure (HF), other valve disease (OVD), right-sided heart disease (RSHD), and others that impact mortality. Optum data from January 1, 2007, through December 31, 2018 included patients age ≥18 years with TR and 12 months of continuous health plan enrollment before TR. Exclusion criteria were end-stage renal disease or known/primary organ pathology. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Colin M. Barker, David P. Cork, Peter A. McCullough, Hirsch S. Mehta, Joanna Van Houten, Candace Gunnarsson, Michael Ryan, William Irish, Sarah Mollenkopf, Patrick Verta Source Type: research

Unpredictability of Ventricular Arrhythmias in Takotsubo Syndrome: Echocardiography to the Rescue!
Ventricular arrhythmias (VA), that is, frequent ventricular premature complexes, monomorphic ventricular tachycardia, both nonsustained and sustained, torsades de pointes, ventricular fibrillation, and sudden cardiac death (SCD), are known to be frequent in patients with takotsubo syndrome (TTS), and are characterized by their unpredictability in regards to the timing of their occurrence during hospitalization.1 –6 Also, well known is the association of such VA with alterations of repolarization (negative T waves) and prolonged corrected QT-interval by the Bazzet formula (QTc), although VA are seen in patients with o...
Source: The American Journal of Cardiology - December 28, 2020 Category: Cardiology Authors: John E. Madias Source Type: research

Incidence, Predictors, and Outcome of In-Hospital Bleeding in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction
The objective was to investigate incidence and outcome of bleeding complications among unselected patients with AMI complicated by cardiogenic shock (AMICS) and referred for immediate revascularization. Bleeding events were assessed by review of medical records in consecutive AMICS patients admitted between 2010 and 2017. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 28, 2020 Category: Cardiology Authors: Hanna Ratcovich, Jakob Josiassen, Ole K.L. Helgestad, Louise Linde, Golnaz Sadjadieh, Thomas Engstr øm, Lisette O. Jensen, Hanne B. Ravn, Henrik Schmidt, Christian Hassager, Jacob E. Møller, Lene Holmvang Source Type: research

Prognostic Value and Interplay Between Myocardial Tissue Velocities in Patients Undergoing Coronary Artery Bypass Grafting
Early diastolic tissue velocity (e ’) by tissue Doppler imaging represents an early marker of left ventricular (LV) dysfunction in ischemic heart disease. We assessed the value of e’ for predicting mortality in patients undergoing coronary artery bypass grafting (CABG). We retrospectively investigated patients treated with CABG b etween 2006-2011. Before surgery, all patients underwent an echocardiogram with tissue Doppler imaging to measure tissue velocities: systolic (s’), e’, and late diastolic (a’). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 28, 2020 Category: Cardiology Authors: Flemming Javier Olsen, S øren Lindberg, Thomas Fritz-Hansen, Daniel Modin, Sune Pedersen, Allan Iversen, Søren Galatius, Gunnar Gislason, Rasmus Møgelvang, Tor Biering-Sørensen Source Type: research

Inappropriate Dosing of Direct Oral Anticoagulants in Patients with Atrial Fibrillation
Direct Oral Anticoagulants (DOACs) require dose adjustment based on specific patient characteristics, making them prone to incorrect dosing. The current study aimed to evaluate the prevalence of inappropriate DOAC dosing, its predictors, and corresponding outcomes in a single-center cohort of AF patients. We reviewed all patients with AF treated at Mayo Clinic with a DOAC (Apixaban, Rivaroxaban, or Dabigatran) between 2010 and 2017. Outcomes examined were ischemic stroke /transient ischemic attack (TIA)/embolism and bleeding. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 28, 2020 Category: Cardiology Authors: Alan Sugrue, David Sanborn, Mustapha Amin, Medhat Farwati, Haarini Sridhar, Azza Ahmed, Ramila Mehta, Konstantinos C. Siontis, Siva K. Mulpuru, Abhishek J. Deshmukh, Bernard J. Gersh, Samuel J Asirvatham, Malini Madhavan Source Type: research

Short-Term Outcomes of Transcatheter Aortic Valve Implantation versus Surgical Aortic Valve Replacement in Kidney Transplant Recipients (From the US Nationwide Representative Study)
Kidney transplant recipients (KTRs) are considered high-risk patients for surgical interventions. Transcatheter aortic valve implantation (TAVI) has been introduced as an alternative to surgical aortic valve replacement (SAVR) in patients with aortic stenosis (AS) at high operative risk. However, the outcomes of TAVI compared to SAVR KTRs have not been well-studied in nationally representative data. Patients with prior history of functioning kidney transplant who were hospitalized for TAVI and SAVR between January 2012 and December 2017 were identified retrospectively in the Nationwide Readmissions Database. (Source: The A...
Source: The American Journal of Cardiology - December 28, 2020 Category: Cardiology Authors: Omar M. Abdelfattah, Anas M. Saad, Abdelrahman Aboshouk, Mohamed Hassanein, Toshiaki Isogai, Mohamed M. Gad, Keerat Rai Ahuja, James Yun, Amar Krishnaswamy, Samir Kapadia Source Type: research

Effect of Losartan or Atenolol on Children and Young Adults with Bicuspid Aortic Valve and Dilated Aorta
Bicuspid (bicommissural) aortic valve (BAV) is a very common congenital heart defect,1-3 is highly heritable,4-8 and is often accompanied by proximal aortic disease (aortopathy).9-12 BAV aortopathy is defined as dilation of the aortic root (AoRt) and/or ascending aorta (AsAo). This aortopathy is frequently present and persistent throughout childhood and adolescence,13 AoRt and AsAo dilation may also be present without clinically significant aortic valve stenosis or insufficiency,13,14 and progresses more rapidly compared to the normal population. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 28, 2020 Category: Cardiology Authors: Assistant Professor of Pediatrics Jonathan N. Flyer, Associate Professor of Pediatrics Lynn A. Sleeper, Professor of Pediatrics Steven D. Colan, Assistant Professor of Pediatrics Michael N. Singh, Associate Professor of Pediatrics Ronald V. Lacro Source Type: research