Readers ’ Comments: Aspirin and/or Other Antiplatelet Agents for the Prevention of Infective Endocarditis
Infective endocarditis (IE) is a relatively rare disease with frequent fatal outcome and devastating morbidity, with a long “intubation” period, in the sense that patients harboring IE-predisposing factors (congenital and rheumatic or other acquired heart diseases with valvular abnormalities, implanted artificial and biological valves and cardiac electronic devices, etc) may develop the disease decades after exposure to such factors. Antibiotic prophylaxis (AP) is recommended prior to invasive procedures (e.g. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: John E. Madias Source Type: research

Prevention Guidelines as Failed Minimal Standards of Care
Clinical practice guidelines have garnered considerable interest among clinicians and researchers in cardiovascular medicine. Among the guidelines, the prevention of coronary heart disease receives great attention as a summary of the clinical trials addressing primary and secondary prevention. One of the challenges to guidelines committees is reduction to clinical practice. Because it can be difficult to gain consensus from experts on broad statements, the final guidelines product represents a compromise which may not serve as a sufficient safety net for patients. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: Peter A. McCullough Source Type: research

“Stupid Doctor Mistakes: Part Three of Many”
In this series of Editorials, I focus on those physicians who think that being a doctor makes them smart at everything; they don't know their limitations. This inability to control ego and arrogance can cost them a lot of money. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 13, 2020 Category: Cardiology Authors: Robert M. Doroghazi Tags: Editorial Source Type: research

Editorial Board
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 12, 2020 Category: Cardiology Source Type: research

Contents
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 12, 2020 Category: Cardiology Source Type: research

Acute Isolated Coronary Artery Dissection Causing Massive Acute Myocardial Infarction and Leading to Unsuccessful Coronary Bypass, Extracorporeal Life Support, and Successful Cardiac Transplantation
Described herein is a 42-year-old woman who suddenly developed a spontaneous isolated coronary arterial dissection which led to massive acute myocardial infarction with shock, unsuccessful coronary artery bypass grafting, transiently successful extracorporeal life support, and finally successful heart transplant. Such a sequence of events is exceedingly rare for patients with coronary dissection and prompted this report. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 11, 2020 Category: Cardiology Authors: Julie Cox, William C. Roberts, Faris G. Araj, Jamie Jarzembowski, Cesar Y. Guerrero-Miranda, Andrea Cooley, Charles S. Roberts, Dan M. Meyer Source Type: research

Diagnostic Implications in the Aftermath of the ISCHEMIA Trial
This article considers whether the debate should be re-focussed even prior to selecting any diagnostic test. The case is made to prioritize risk factor management and empiric angina pectoris control as part of optimal secondary prevention followed by expeditious clinical reassessment to determine adequacy of therapeutic responses, including quality of life, prior to embarking on diagnostic testing. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 11, 2020 Category: Cardiology Authors: G. B. John Mancini, William E. Boden Source Type: research

Prognostic Value of N-Terminal Pro-form B-type Natriuretic Peptide in Patients With Moderate Aortic Stenosis
Serum B-type natriuretic peptide (BNP) and the N-terminal pro-form, NT-proBNP, which are produced by the cleavage of proBNP are well known predictors of prognosis in heart failure.1 Values correlate with the severity of aortic stenosis (AS) and are associated with symptomatic status and adverse clinical outcomes.2-5 However, the risk stratification of patients with moderate AS is still incipient and predictors of poor outcomes have not been clearly established. Some of these patients may have concomitant comorbidities that may evaluation more complex. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 11, 2020 Category: Cardiology Authors: Saki Ito, William R. Miranda, Allan S. Jaffe, Jae K. Oh Source Type: research

Effect of Physical Exercise Training in Patients With Chagas Heart Disease (From the PEACH STUDY)
Chagas disease is an infection caused by Trypanosoma cruzi, with cardiac involvement in 25-30% in the chronic phase as a result of an inflammatory process which leads to cell death, fibrosis, and cardiac remodeling 1. Recent guidelines recommend regular physical activity and structured exercise training as a complementary therapy in cardiac patients 2. However, only few studies have evaluated the effect of exercise training in patients with Chagas heart disease (HD). Considering the worst prognosis of Chagas HD when compared to other etiologies3, randomized clinical trials are needed to investigate the effects of exercise ...
Source: The American Journal of Cardiology - February 10, 2020 Category: Cardiology Authors: Fernanda de Souza Nogueira Sardinha Mendes, Mauro Felippe Felix Mediano, Fernando Cesar de Castro e Souza, Paula Simpl ício da Silva, Fernanda Martins Carneiro, Marcelo Teixeira de Holanda, Roberto Magalhães Saraiva, Sergio Salles Xavier, Pedro Emmanuel Source Type: research

Hypertrophic Cardiomyopathy in “Real World” Community Cardiology Practice
We report here a cross-sectional analysis of 253 consecutive HC patients from a “real world” clinical cardiology setting. When compared to highly selected referral center cohort, patients in clinical practice proved to be similar with regard to disease expression such as LV wall thickness, outflow obstruction, and natural history, including stable and largely benign clinica l course with NYHA class I/II symptoms (61% in community practice vs. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 10, 2020 Category: Cardiology Authors: Ethan J. Rowin, Martin S. Maron, Viraj Bhatt, Linda Gillam, Barry J. Maron Source Type: research

Cardiovascular Safety Considerations in the Treatment of Neurogenic Orthostatic Hypotension
Neurogenic orthostatic hypotension (nOH), a drop in blood pressure upon standing resulting from autonomic malfunction, may cause debilitating symptoms that can affect independence in daily activities and quality-of-life. nOH may also be associated with cardiovascular comorbidities (e.g., supine hypertension, heart failure, diabetes, arrhythmias), making treatment decisions complicated and requiring management that should be based on a patient's cardiovascular profile. Additionally, drugs used to treat the cardiovascular disorders (e.g., vasodilators, β-blockers) can exacerbate nOH and concomitant symptoms. (Source: Th...
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Brian Olshansky, James Muldowney Source Type: research

Predictors of Long-term Outcome of Isolated Surgical Aortic Valve Replacement in Aortic Regurgitation with Reduced Left Ventricular Ejection Fraction and Extreme Left Ventricular Dilatation
Management of severe aortic regurgitation (AR) in patients with reduced left ventricular function and extreme left ventricular dilatation presents a therapeutic dilemma.1 Current American College of Cardiology/American Heart Association(ACC/AHA) guideline and European Society of Cardiology/European Association of Cardiac and Thoracic Surgery(ESC/EACTS) guidelines recommend surgical intervention in severe AR patients with left ventricular ejection fraction (LVEF) of less than 50% as class I level. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Nianguo Dong, Weiwei Jiang, Ping Yin, Xingjian Hu, Yin Wang Source Type: research

Outcomes of Left Ventricular Assist Device Implantation in Patients with Uncommon Etiology Cardiomyopathy
This study aimed to characterize patients with uncommon cardiomyopathy etiologies and examine the outcomes between uncommon and ischemic/idiopathic dilated cardiomyopathy. This observational study was conducted in 19 centers between 2006 and 2016. Baseline characteristics and outcomes of patients with uncommon etiology were compared to patients with idiopathic dilated/ischemic cardiomyopathies. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Vincent Galand, Erwan Fl écher, Céline Chabanne, Bernard Lelong, Céline Goéminne, André Vincentelli, Clément Delmas, Camille Dambrin, François Picard, Frédéric Sacher, Michel Kindo, Tam Hoang Minh, Philippe Gaudard, Philippe Rouvière, Thomas Sé Source Type: research

Timing and Outcomes of Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation
Limited data exist regarding the timing of percutaneous coronary intervention (PCI) in patients with coronary artery disease undergoing transcatheter aortic valve implantation (TAVI). We aimed to investigate clinical outcomes of patients undergoing TAVI and planned PCI according to the timing of PCI in relation to the TAVI. Consecutive patients with severe aortic stenosis who underwent TAVI with planned PCI between January 2013 and November 2017 were included. Patients were divided according to the timing of PCI. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Tomoki Ochiai, Sung-Han Yoon, Nir Flint, Rahul Sharma, Tarun Chakravarty, Danon Kaewkes, Vivek Patel, Mamoo Nakamura, Wen Cheng, Raj Makkar Source Type: research

Impact of Predilatation Prior to Transcatheter Aortic Valve Implantation with the Self-Expanding Acurate neo Device (From the Multicenter NEOPRO Registry)
Safety and feasibility of transfemoral Acurate neo implantation without systematic predilatation are not fully investigated. Our aim was to evaluate the use and impact of pre-implantation balloon aortic valvuloplasty (pre-BAV) before transcatheter aortic valve implantation (TAVI) with Acurate neo. The NEOPRO Registry retrospectively included 1,263 patients who underwent transfemoral TAVI with Acurate neo at 18 centers between January 2012 and March 2018. Information on pre-BAV was available for 1,262 patients (99.9%). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Matteo Pagnesi, Won-Keun Kim, Lenard Conradi, Marco Barbanti, Giulio G. Stefanini, Joachim Schofer, David Hildick-Smith, Thomas Pilgrim, Alexandre Abizaid, David Zweiker, Luca Testa, Maurizio Taramasso, Alexander Wolf, John G. Webb, Alexander Sedaghat, Ja Source Type: research

Valve-in-Valve Transcatheter Implantation versus Redo Surgical Aortic Valve Replacement
Valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) for a failing prosthesis is an appealing alternative to redo surgical AVR. We utilized data from the US National Inpatient Sample for the period 2012-2016 to identify hospitalizations for either ViV-TAVI or redo-SAVR. The primary outcomes of interest were in-hospital adverse events composite outcome (comprising of mortality, myocardial infarction, stroke, or acute kidney injury) and all-cause mortality. We used propensity score matching to adjust for the baseline differences between ViV-TAVI and redo-SAVR cohorts. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Aaqib H. Malik, Srikanth Yandrapalli, Syed Zaid, Suchith S Shetty, Wilbert S. Aronow, Hasan Ahmad, Gilbert H.L. Tang Source Type: research

Features of Sitosterolemia in Children
Sitosterolemia is a rare lipid metabolism disease with heterogeneous manifestations. Atherosclerosis can occur in children, and therefore, early detection, diagnosis, and treatment of this disease are important. We studied 18 pediatric patients with sitosterolemia who showed a significant increase in plasma lipid levels and analyzed their clinical, biochemical, and genetic characteristics. We recorded the initial serum lipid results and clinical manifestations of the patients. Lipid and plant sterol levels were measured after homozygous or compound heterozygous mutations of ABCG5 or ABCG8 were identified by genetic testing...
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Liyuan Xu, Wenhui Wen, Ya Yang, Jinjie Xie, Rongjuan Li, Yue Wu, Yifei Hu, Luya Wang, Mei Chong Source Type: research

Relation of Frailty to Outcomes after Catheter Ablation of Atrial Fibrillation
Catheter ablation for AF improves outcomes compared with medical treatment alone. Risk stratification for outcomes following AF ablation remains an important area of uncertainty. This analysis evaluated the association between frailty and outcomes following atrial fibrillation (AF) ablation. We evaluated US inpatients receiving AF ablation between January 1, 2016 and December 1, 2016 using Medicare fee-for-service billing codes. Diagnosis codes were used to calculate patients ’ Hospital Frailty Risk Score, with the cohort divided according to established cut-points of low (15) risk for frailty. (Source: The American ...
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Harun Kundi, Peter A. Noseworthy, Linda R. Valsdottir, Changyu Shen, Xiaoxi Yao, Robert W. Yeh, Daniel B. Kramer Source Type: research

Factors Modifying the Risk of Atrial Fibrillation Associated with Atrial Premature Complexes in Patients with Hypertension
Patients with hypertension who develop atrial premature complexes (APCs) are at a particularly high risk for atrial fibrillation (AF). We sought to identify medications and modifiable risk factors that could reduce the risk of AF imposed by presence of APCs in such a high risk group. This analysis included 4,331 participants with treated hypertension from the REGARDS study who were free of AF and cardiovascular disease at the time of enrollment (2003-2007). APCs were detected in 8.2% (n=356) of the participants at baseline. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Elsayed Z. Soliman, George Howard, Suzanne Judd, Prashant D. Bhave, Virginia J. Howard, David M. Herrington Source Type: research

Comparison of 30-day Unplanned Readmissions to the Index Versus Non-Index Hospital After Percutaneous Coronary Intervention
This study aims to evaluate the rates, causes, and outcomes for unplanned readmissions following percutaneous coronary intervention (PCI) depending on whether the patients were admitted to the index or non-index hospital. Patients undergoing PCI between 2010 and 2014 in the U.S. Nationwide Readmission Database were evaluated for unplanned readmissions at 30 days to index and non-index hospitals. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Chun Shing Kwok, Ankur Kalra, Poonam Velagapudi, Ki Park, Mohamed Mohamed, M Chadi Alraies, Richard K Cheng, Rodrigo Bagur, Mamas A. Mamas Source Type: research

Impact Of Cirrhosis On 90-Day Outcomes After Percutaneous Coronary Intervention (From A Nationwide Database)
The prevalence of coronary artery disease (CAD) is elevated in patients with cirrhosis,1-3 and cirrhotics with CAD may require coronary revascularization for various clinical scenarios. However, coronary artery bypass surgery is often not an option due to significantly elevated surgical risks, and cirrhotics are referred for percutaneous coronary intervention (PCI) instead.4-6 When performed in patients with cirrhosis, PCI can also be associated with significantly increased risks compared to the general population, due to the presence of factors such as underlying kidney disease, coagulopathy, thrombocytopenia, and varices...
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Daniel Y Lu, Diala Steitieh, Dmitriy N Feldman, Jim W Cheung, S. Chiu Wong, Hadi Halazun, Karim J Halazun, Nivee Amin, Joseph Wang, John Chae, Robert L Wilensky, Luke K Kim Source Type: research

Outcomes of Renal Transplant Recipients after Percutaneous Coronary Intervention
This study aimed to elucidate the effect of RT on clinical outcomes after PCI. Renal transplant recipients who underwent PCI from 2002 to 2017 were enrolled. To evaluate the effectiveness of RT, we retrospectively reviewed HD patients who underwent PCI. Propensity-score matching was performed using logistic regression to control for differences in baseline characteristics. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 8, 2020 Category: Cardiology Authors: Masashi Nakao, Junichi Yamaguchi, Natsuko Satomi, Suguru Ebihara, Kazuki Tanaka, Hisao Otsuki, Yusuke Inagaki, Kentaro Jujo, Hiroyuki Arashi, Nobuhisa Hagiwara Source Type: research

Sex Differences in In-Hospital Outcomes of Transcatheter Mitral Valve Repair (From a National Database)
There is paucity of data on sex differences in outcomes of transcatheter mitral valve repair (TMVR). We queried the NIS database (2012-2016) to identify hospitalizations for TMVR. We conducted a propensity matching analysis to compare hospitalizations for TMVR in men versus women. Our analysis yielded 10,014 hospitalizations for TMVR. TMVR was increasingly performed in both sexes at similar rate. Compared with men, women undergoing TMVR had fewer major comorbidities. After matching, there was no difference in in-hospital mortality between men and women (3.0% vs 2.4%, p=0.33). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Ayman Elbadawi, Mohamed Elzenaini, Ravi Thakkar, Karim Mahmoud, Islam Y. Elgendy, Michael Megaly, Mohamed Hamed, Mohmed A. Omer, Medhat Chowdhury, Gbolahan Ogunbayo, Diaa Kamal, Uma Rangassety, Hani Jneid, Syed Gilani, Wissam Khalife Source Type: research

Frequency and Significance of Coronary Artery Disease and Myocardial Bridging in Patients with Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HC) is the most common inherited cardiac disease that affects at least 0,2% of the general population.1 Although many patients diagnosed with HC present without or with minimal physical symptoms, a substantial group will experience mild to severe chest pain. The etiology of chest pain in HC patients is complex and includes myocardial ischemia, an increased metabolic demand and reduced myocardial blood supply.1-3 HC patients are not exempt from coronary artery disease (CAD). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Nikki van der Velde, Roy Huurman, Yuzo Yamasaki, Isabella Kardys, Tjebbe W Galema, Ricardo PJ Budde, Felix Zijlstra, Gabriel P Krestin, Arend FL Schinkel, Michelle Michels, Alexander Hirsch Tags: Myocardial bridging in hypertrophic cardiomyopathy Source Type: research

Pattern and Impact of Off-label Underdosing of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation Who Are Indicated for Standard Dosing
With safety concerns about increasing bleeding, off-label underdosing of non-vitamin K antagonist anticoagulants (NOACs) is common in East Asian patients with atrial fibrillation (AF). We tried to investigate the pattern of NOAC underdosing and associated clinical outcomes in patients with AF who are indicated for standard dosing. Using the Korean National Health Insurance Service database, we evaluated 16568 patients with a new prescription of NOAC who are indicated for standard NOAC dosing and compared 4536 patients with warfarin with respect to thromboembolic events (ischemic stroke or systemic embolization), all-cause ...
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Min Soo Cho, Ji Eun Yun, Ji Jeong Park, Yun Jung Kim, Jessie Lee, Hyungmin Kim, Duk-Woo Park, Gi-Byoung Nam Source Type: research

Basal Ventricular Septal Hypertrophy in Systemic Hypertension
Basal septal hypertrophy (BSH) is commonly seen in patients with systemic hypertension and has been associated with increased afterload. The impact of localized hypertrophy on left ventricular (LV) and left atrial (LA) function is still unclear. Our aim is to investigate if BSH is a marker of a more pronounced impact of hypertension on cardiac function in the early stages of hypertensive heart disease. An echocardiogram was performed in 163 well-controlled hypertensive patients and 22 healthy individuals. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Filip Loncaric, Loredana Nunno, Maria Mimbrero, Maciej Marciniak, Joao Filipe Fernandes, Laia Tirapu, Dora Fabijanovic, Laura Sanchis, Adelina Doltra, Maja Cikes, Pablo Lamata, Bart Bijnens, Marta Sitges Source Type: research

Anemia, Mortality, and Hospitalizations in Heart Failure with a Preserved Ejection Fraction (From the TOPCAT Trial)
With the increase in the prevalence of heart failure (HF), there has been a proportionate rise in the number of patients with heart failure and a preserved ejection fraction (HFpEF).1 While the morbidity and mortality associated with heart failure with a reduced ejection fraction (HFrEF) has been reduced with many evidence-based therapies, few currently available treatment strategies have shown clinical benefit in HFpEF.2-6 Comorbidities are a major driver of the morbidity and mortality burden in HFpEF. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Kartik Gupta, Rajat Kalra, Indranee Rajapreyar, Joanna Joly, Mike Pate, Marc G. Cribbs, Sameer Ather, Sumanth D. Prabhu, Navkaranbir S. Bajaj Source Type: research

Contemporary Trends and Outcomes of Percutaneous and Surgical Mitral Valve Replacement or Repair in Patients with Cancer
In the era of emerging options for mitral valvular intervention, we sought to characterize the relative utilization, outcomes, and post-hospital dispositions of patients referred for transcatheter mitral valve repair (TMVRepair) and surgical mitral valve procedures (SMVP), by cancer-status. Leveraging the National Inpatient Sample, a representative national dataset, ICD-9 codes for all adults>18 years with comorbid mitral regurgitation, and cancer without metastatic disease admitted from 2003-2015 were queried. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 7, 2020 Category: Cardiology Authors: Avirup Guha, Amit Kumar Dey, Shuab Omer, William T. Abraham, Guilherme Attizzani, Hani Jneid, Daniel Addison Source Type: research

Adherence to Triple-Free-Drug Combination Therapies among Patients with Cardiovascular Disease
Combination therapies are often needed to modify the concomitant risk factors for cardiovascular disease (CVD). Non-adherence to cardiovascular medications is a relevant concern, especially in polytherapy. We conducted a population-based, cohort study with the aim of quantifying the level of non-adherence and its related determinants in patients exposed to free three-drug combination therapies, namely concurrent use of angiotensin-converting-enzyme inhibitor (ACEi), calcium channel blockers (CCBs), and statins or of ACEi, statins, and low-dose aspirin. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 6, 2020 Category: Cardiology Authors: Niccol ò Lombardi, Giada Crescioli, Monica Simonetti, Ettore Marconi, Alfredo Vannacci, Alessandra Bettiol, Damiano Parretti, Claudio Cricelli, Francesco Lapi Source Type: research

Asymptomatic patients without known heart disease have markers of occult heart disease
Left ventricular dysfunction is a significant predictor of sudden cardiac death (SCD), however, more SCDs occur among patients with preserved/minimally depressed left ventricular function.1 (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 4, 2020 Category: Cardiology Authors: Leonardo Tamariz, Ana Palacio, Robert Myerbug, Joel Fishman, Jeffrey J. Goldberger Source Type: research

Simpson's Paradox: Meta-Analysis Comparing Torsemide Versus Furosemide in Patients With Heart Failure
Abraham and colleagues performed a systematic review and meta-analysis of observational studies and randomized trials comparing torsemide and furosemide for patients with heart failure (HF).1 They examined multiple outcomes, including hospitalizations due to HF. The forest plot in figure 4 shows that a total of 100/944 (10.6%) patients taking torsemide were hospitalized due to HF, versus 198/1078 (18.4%) patients taking furosemide. There is a 7.8 percentage point reduction in HF hospitalizations for patients taking torsemide. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 3, 2020 Category: Cardiology Authors: Amiran Baduashvili Source Type: research

“Stupid Doctor Mistakes: Part Two of Many”
Physicians can make the same mistakes as any investor. They also make mistakes due to lack of instruction on how to invest the hard-earned fruits of their labor, and blind trust. In this series of Editorials I discuss mistakes due to ego and arrogance. Physicians are smart people. Unfortunately, some think that makes them smart at everything. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 1, 2020 Category: Cardiology Authors: Robert M. Doroghazi Tags: Editorial Source Type: research

Presentation, Treatment, and Outcome of Survivors of In-Hospital versus Out-of-Hospital Sudden Cardiac Arrest
We examined the baseline characteristics, rates of implantable cardioverter defibrillator (ICD) implantation and long-term all-cause mortality for survivors of in-hospital (IHSCA) versus out-of-hospital (OHSCA) sudden cardiac arrest (SCA). A total of 1,433 SCA survivors (807 IHSCA and 626 OHSCA) from 2002 - 2012 were followed through February 2017. Baseline characteristics and potential triggers of SCA, including significant electrolyte and metabolic abnormalities and acute myocardial infarction (MI) and ischemia, were collected. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Almut Troeller McDermott, Vincenzo B. Polsinelli, Norman C. Wang, Krishna Kancharla, Aditya Bhonsale, Sandeep K. Jain, Samir Saba Source Type: research

Novel Anatomic Predictors of New Persistent Left Bundle Branch Block after Evolut Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation(TAVI) is now approved in the United States in patients with symptomatic severe aortic stenosis regardless of surgical risks.1,2 While increasing operator experience, better patient selection and newer-generation transcatheter heart valves(THV) have helped optimize TAVI outcomes,3,4 conduction disturbances requiring permanent pacemaker(PPM) and new persistent left bundle branch block(NP-LBBB) remain unsolved issues.1,2 Recent data showed that NP-LBBB after TAVI could impact mortality and rehospitalization, PPM implantation and adverse left ventricular function recovery. (Source: The A...
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Syed Zaid, Aditya Sengupta, Kimberly Okoli, Melissa Tsoi, Asaad Khan, Hasan Ahmad, Joshua B. Goldberg, Cenap Undemir, Anna Rozenshtein, Nish Patel, Muhammad Khan, Eisha Gupta, Jason Kovacic, Steven L. Lansman, George D. Dangas, Samin K. Sharma, Annapoorna Source Type: research

Meta-analysis Evaluating the Effects of Renin-Angiotensin-Aldosterone System Blockade on Outcomes of Heart Failure with Preserved Ejection Fraction
Clinical trials of renin-angiotensin-aldosterone system (RAAS) antagonists in heart failure with preserved ejection fraction (HFpEF) have suggested neutral results and treatment is focused on associated symptoms and comorbidities. MEDLINE and EMBASE were searched through October 2019 for randomized controlled studies investigating the effects of different RAAS antagonists in patients with HFpEF. The main outcomes were all-cause mortality, trial defined cardiovascular mortality and heart failure (HF) hospitalizations. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Toshiki Kuno, Hiroki Ueyama, Tomohiro Fujisaki, Artemis Briasouli, Hisato Takagi, Alexandros Briasoulis Source Type: research

Impact of Anemia on the Risk of Bleeding Following Percutaneous Coronary Interventions in Patients ≥ 75 Years of Age
The accurate balance of thrombotic and bleeding risks is an essential step of percutaneous coronary interventions (PCI). Older adults are a growing and particularly challenging group since they combine amyloid angiopathy, platelet hyperreactivity and complex anatomies that make them prone to adverse events.1-5 Despite the increased risk, they benefit from intervention, so risk stratification is particularly important.6-8 Clinical scales are laborious and of limited utility.9 Thus, any factor that allows rapid and easy classification of patients will be remarkably useful. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: David Mart í-Sánchez, Damaris Carballeira, María José Morales, Ricardo Concepción, Hugo del Castillo, Alexander Marschall, Freddy Andrés Delgado-Calva, Carmen Dejuán-Bitriá, Joaquín Pérez-Guzmán, Edurne López-Soberón, Jorge Palazuelos, Salvad Source Type: research

Effect on Mortality with Inferior Vena Cava Filters in Patients Undergoing Pulmonary Embolectomy
In the absence of a randomized controlled trial, it is important to obtain as much evidence as possible by other methods on whether inferior vena cava (IVC) filters reduce mortality in patients undergoing pulmonary embolectomy. Therefore, this retrospective cohort study based data from the National Inpatient Sample, 2009-2014. was undertaken. We assessed in-hospital all-cause mortality in stable and unstable (in shock or on ventilator support) patients with acute pulmonary embolism (PE) who underwent pulmonary embolectomy. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Paul D Stein, Fadi Matta, Mary J. Hughes Source Type: research

Long-term Follow-up of Transcatheter Aortic Valve Implantation with Portico vs. Evolut devices
New-generation devices such as Evolut and Portico have provided favorable results in patients undergoing transcatheter aortic valve implantation (TAVI) for aortic stenosis, but their comparative effectiveness remains debated, despite its relevance when envisioning TAVI in low-risk patients. We evaluated the safety and efficacy of 2 leading TAVI devices (Evolut and Portico) used by the same team of experienced TAVI operators, focusing long-term outcomes, including the major adverse events (i.e. the composite of death, stroke, myocardial infarction, major vascular complication or major bleeding). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Nicola Corcione, Giuseppe Biondi-Zoccai, Paolo Ferraro, Alberto Morello, Sirio Conte, Michele Cimmino, Carlo Vigna, Giacomo Frati, Giovanni De Persio, Luca Altamura, Fabrizio Tomai, Andrea Berni, Mauro Cassese, Martino Pepe, Arturo Giordano Source Type: research

Usefulness of Serum Free Thyroxine Concentration to Predict Ventricular Arrhythmia Risk in Euthyroid Patients with Structural Heart Disease
Sudden cardiac death continues to be a major cause of death in patients with structural heart disease, and accounts for approximately 50% of total cardiovascular mortality. To prevent sudden cardiac death, current guidelines recommend that patients with heart failure and reduced left ventricular systolic function receive primary prevention cardioverter-defibrillator (ICD) devices, with supporting evidence from multiple clinical trials.1 For over two centuries, thyroid disease and cardiac arrhythmias have been shown to be closely associated. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Patrick M üller, Johannes W. Dietrich, Tina Lin, Alexandru Bejinariu, Stephan Binnebößel, Friederike Bergen, Jan Schmidt, Sarah-Kristin Müller, Apostolos Chatzitomaris, Muhammed Kurt, Shqipe Gerguri, Lukas Clasen, Harald H. Klein, Malte Kelm, Hisaki M Source Type: research

Rates and Independent Correlates of 10-Year Major Adverse Events and Mortality in Patients Undergoing Left Main Coronary Arterial Revascularization
Patients undergoing myocardial revascularization for significant left main coronary artery disease (LMCA) are at high risks of ischemic events and death during follow-up. We sought to determine the independent correlates for very long-term outcomes after LMCA revascularization, which would be clinical value for risk stratification in such high-risk patients. The 10-year rates of clinical outcomes and independent correlates of adverse events were evaluated in 2,240 patients with LMCA disease in the MAIN-COMPARE registry, including 1,102 patients who underwent stenting and 1,138 who underwent coronary-artery bypass grafting ...
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Tae Oh Kim, Jung-Min Ahn, Do-Yoon Kang, Seon Ok Kim, Sangwoo Park, Hanbit Park, Pil Hyung Lee, Seung-Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park Source Type: research

Nationwide Frequency, Sequential Trends, and Impact of Comorbid Mental Health Disorders on Hospitalizations, Outcomes, and Healthcare Resource Utilization in Adult Congenital Heart Disease
Despite the growing prevalence of adult congenital heart disease (ACHD), data on trends in prevalence of mental health disorders (MHD) among patients with ACHD remain limited. The National Inpatient Sample (2007-2014) was queried to identify the frequency and trends of MHD among ACHD hospitalizations (stratification by age, sex, and race); demographics and comorbidities for ACHD cohorts, with (MHD+) vs. without MHD (MHD-); the rate and trends of all-cause in-hospital mortality, disposition, mean length of stay (LOS), and hospitalization charges among both cohorts. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Rupak Desai, Krupa Patel, Hitanshu Dave, Kaushal Shah, Natalie DeWitt, Hee Kong Fong, Yash Varma, Kaksha Varma, Zeeshan Mansuri, Rajesh Sachdeva, Amber Khanna, Gautam Kumar Tags: Original Research (Clinical Research) Source Type: research

N-terminal Pro B-type Natriuretic Peptide and High-sensitivity Cardiac Troponin as Markers for Heart Failure and Cardiovascular Disease Risks According to Glucose Status (From the Multi-Ethnic Study of Atherosclerosis [MESA])
We examined the individual and combined relations of N-terminal natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) levels among asymptomatic adults with pre-DM and DM with the development of incident heart failure (HF) and cardiovascular disease (CVD) events. 5,584 participants with biomarker measures aged 45-84 years were included from the Multi-Ethnic Study of Atherosclerosis, of which 4,090 were normoglycemic, 799 had pre-DM, and 695 had DM at baseline and were followed for 12.4 ± 3.8 years. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Khoa Nguyen, Wenjun Fan, Alain Bertoni, Matthew J. Budoff, Christopher Defilippi, Dawn Lombardo, Alan Maisel, Moyses Szklo, Nathan D. Wong Source Type: research

Effect of Ventricular Pacing on Morbidity in Adults After Fontan Repair
The Fontan is the final circulatory destination for palliation of complex congenital heart defects when anatomy precludes a two-ventricle repair. Advances in surgical technique and post-operative management have been accompanied by improved early survival,1-3 but late morbidity and mortality remains high with 20-year survival estimated between 60%-80%.4-7 Bradycardia necessitates permanent pacemaker (PPM) implantation in 6-39% of Fontan patients,8-14 with atrioventricular block as the indication in 20-50% of cases. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Jonathan D Kochav, Marlon Rosenbaum, Stephanie M Kochav, Emily Slater, Noa Wassercug-Zemer, Matthew J Lewis Source Type: research

Pet Ownership and Cardiovascular Health in the US general population
The 2013 American Heart Association Scientific Statement on pet ownership and cardiovascular risk suggested that dog ownership is probably associated with decreased cardiovascular risk. Several studies have been shown that pet ownership, particularly of dogs, is associated with increased physical activity levels, social support, and improved outcomes after a major cardiovascular event. We hypothesized that pet ownership is associated with a lower risk of cardiovascular disease in the U.S. general population. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 29, 2020 Category: Cardiology Authors: Chayakrit Krittanawong, Anirudh Kumar, Zhen Wang, Hani Jneid, Salim S. Virani, Glenn N Levine Source Type: research

Marital Status and Long-Term Outcomes in Mild Heart Failure Patients with an Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy with Defibrillator
Married patients have been shown to have a lower risk for adverse cardiovascular outcomes. However, the risk of heart failure (HF) or death in married versus unmarried patients with left ventricular (LV) dysfunction and an implantable cardioverter defibrillator (ICD), and the effect of cardiac resynchronization therapy with defibrillator (CRT-D) are unknown. In MADIT-CRT, among patients with LBBB, we evaluated long-term clinical outcomes of all-cause mortality or HF events in married (including common law status) compared to unmarried (single/divorced/widowed) patients with CRT-D vs. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: May Goldenberg, Mehmet K. Aktas, Arwa Younis, Wojciech Zareba, Scott McNitt, Valentina Kutyifa Source Type: research

Meta-Analysis of Intraocular Bleeding with Dual Antiplatelet Therapy using P2Y12 Inhibitors Prasugrel or Ticagrelor
Intraocular bleeding is a devastating clinical event due to its potentially blinding nature. It is not known if determine if dual antiplatelet therapy using aspirin and potent P2Y12 inhibitors increases this risk. We searched MEDLINE and ClinicalTrials.gov for randomized controlled trials that were phase III, randomly assigned patients to dual antiplatelet therapy with either aspirin and a potent P2Y12 inhibitor or aspirin and clopidogrel, had follow-up of 6 months, and at least 200 patients. Corresponding authors were contacted for intraocular bleeding data. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Michelle T. Sun, Sonia Huang, Stephen D. Wiviott, Elliot M. Antman, Matthew T. Roe, E. Magnus Ohman, Megan Neely, Lars Wallentin, Christopher X. Wong Source Type: research

Comparison of Valve Durability and Outcomes of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Patients With Severe Symptomatic Aortic Stenosis and Less-Than-High-Risk for Surgery
This study aimed to investigate the rate of severe structural valve deterioration (SVD) and long-term outcomes of patients with severe symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). Propensity score matched analysis of patients who underwent TAVI (n=216) and SAVR (n=216) between 2008 and 2012. Long-term echocardiographic parameters and clinical outcomes were assessed after more than 6 years after TAVI/SAVR. Rate of severe SVD was 10.5% vs. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Panagiotis Tzamalis, Sofia Alataki, Peter Bramlage, Claus Schmitt, Gerhard Schymik Source Type: research

Meta-Analysis of Transcatheter Versus Surgical Aortic Valve Replacement in Low Surgical Risk Patients
The 2017 American College of Cardiology and American Heart Association (ACC/AHA) guidelines recommend the use of transcatheter aortic valve implantation (TAVI) for the treatment of severe symptomatic aortic stenosis in patients with prohibitive (strength of recommendation: Class I), high (Class I), and intermediate (Class IIa) surgical risk.1 Until recently, little was known concerning TAVI outcomes in individuals at low surgical risk, who constitute the majority of patients with severe aortic stenosis. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Jeremy Y. Levett, Sarah B. Windle, Kristian B. Filion, Vanessa C. Brunetti, Mark J. Eisenberg Source Type: research

Coronary Artery Disease Assessed by Computed Tomography Based Leaman Score in Patients with Low-Risk Transcatheter Aortic Valve Implantation
We aimed to evaluate the burden of coronary artery disease (CAD) using the computed tomography (CT) Leaman score in low-risk transcatheter aortic valve implantation (TAVI) patients. The extent of CAD in low-risk patients with aortic stenosis (AS) who are candidates for TAVI has not been accurately quantified. The CT Leaman score was developed to quantify coronary CT angiography (CCTA) atherosclerotic burden and has been validated to evaluate the extent of CAD. CT Leaman score>5 has been associated with an increase in major adverse cardiac events over long-term follow-up. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Yuichi Ozaki, Hector M. Garcia-Garcia, Toby Rogers, Rebecca Torguson, Paige E. Craig, Alexandre Hideo-Kajita, Paul Gordon, Afshin Ehsan, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Robert Levitt, Chiwon Hahn, Maurice Buchbinder, Nicholas Source Type: research

Meta-analysis Comparing Cryoballoon Versus Radiofrequency as First Ablation Procedure for Atrial Fibrillation
Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. Radiofrequency (RF) represents a standard of care for PVI, while, cryoballoon (CB) ablation has emerged as a valid alternative. The aim of our meta-analysis was to explore the efficacy and safety of CB compared with RF as first ablation procedure for AF. We searched the literature for studies that investigated this issue. The primary efficacy outcome was AF recurrence. The safety outcomes were: pericardial effusion, cardiac tamponade, phrenic nerve palsy, vascular complications, and major bleedings. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 27, 2020 Category: Cardiology Authors: Federico Fortuni, Matteo Casula, Antonio Sanzo, Filippo Angelini, Stefano Cornara, Alberto Somaschini, Giacomo Mugnai, Roberto Rordorf, Gaetano Maria De Ferrari Source Type: research