Incidence and Predictors of Progression in Asymptomatic Patients With Stable Heart Failure
Data from previous heart failure (HF) trials suggest that patients with mild symptoms (NYHA II) actually have a poor clinical outcome. However, these studies did not assess clinical stability and rarely included patients in NYHA I. We sought to determine the incidence of short-term clinical progression in supposedly stable HF patients in NYHA I. In addition, we aimed to investigate the predictive value of widely available electrocardiographic and echocardiographic parameters for short-term disease progression. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 16, 2021 Category: Cardiology Authors: Alexander Marschall, Hugo del Castillo Carnevali, Concepci ón Fernández Pascual, Ana Lorente Rubio, María José Morales Gallardo, Carmen Dejuán Bitriá, Freddy Andrés Delgado Calva, Juan Duarte Torres, Belén Biscotti Rodil, Diego Rodriguez Torres, S Source Type: research

Relation of Serum Uric Acid and Cardiovascular Events in Adults Aged 20-49 Years
In this study, we aimed to identify the association of medication na ïve SUA with incident CVD including myocardial infarction (MI), stroke, heart failure (HF) and atrial fibrillation (AF) using a nationwide epidemiological database. We analyzed 353,613 participants aged 20–49 years, who were not taking uric acid lowering medications, and had no prevalent history of cardiovascular disease (CVD) using a nationwide health claims database collected in the JMDC Claims Database between 2005 and 2018. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 14, 2021 Category: Cardiology Authors: Hikari Seki, Hidehiro Kaneko, Hiroyuki Morita, Hidetaka Itoh, Kojiro Morita, Satoshi Matsuoka, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Yuichiro Yano, Sunao Nakamura, Koichi Node, Hideo Yasunaga, I Tags: Miscellaneous Source Type: research

Effect of Lipoprotein (a) Levels on Long-term Cardiovascular Outcomes in Patients with Myocardial Infarction with Nonobstructive Coronary Arteries
The association between elevated lipoprotein(a) [Lp(a)] and poor outcomes in coronary artery disease (CAD) has been addressed for decades. However, little is known about the prognostic value of Lp(a) in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA). A total of 1179 patients with MINOCA were enrolled and divided into low, medium, and high Lp(a) groups based on the cut-off value of 10 and 30mg/dL. The primary endpoint was major adverse cardiovascular events (MACE), a composite of all-cause death, nonfatal MI, nonfatal stroke, revascularization, and hospitalization for unstable angina or h...
Source: The American Journal of Cardiology - June 12, 2021 Category: Cardiology Authors: Side Gao, Wenjian Ma, Sizhuang Huang, Xuze Lin, Mengyue Yu Source Type: research

Outcomes and Resource Utilization of Atrial Fibrillation Hospitalizations With Type 2 Myocardial Infarction
Scarce data exist on the prognostic impact of type 2 myocardial infarction (MI) in patients with AF. The Nationwide Readmission Database 2018 was queried for primary AF hospitalizations with and without type 2 MI. Complex samples multivariable logistic and linear regression models were used to determine the association between type 2 MI and outcomes (in-hospital mortality, index length of stay [LOS], hospital costs, discharge to nursing facility, and 30-day all-cause readmissions). Of 382,896 weighted primary AF hospitalizations included in this study, 7,375 (1.9%) had type 2 MI. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 12, 2021 Category: Cardiology Authors: Robert W. Ariss, Abdul Mannan Khan Minhas, Salik Nazir, Chandramohan Meenakshisundaram, Muhammad Mobeen Ali, Keerat Rai Ahuja, Robert D. Grande, P. Kasi Ramanathan, Waleed Tallat Kayani, Mujeeb Sheikh Source Type: research

Usefulness of High-Sensitivity Cardiac Troponin T to Predict Long-Term Outcome in Patients with Hypertrophic Cardiomyopathy
Since the first report of an association between cardiac troponin (cTn) and adverse outcome in hypertrophic cardiomyopathy (HD), there is a paucity in confirmative data. We performed a prospective, prespecified 5-year follow-up cohort study of 135 HC patients who participated in a national multicenter project and underwent clinical evaluation, MRI (cine, LGE and T2-weighted imaging) and biomarker assessment (high-sensitivity cTnT (hs-cTnT), N-terminal pro-B-type natriuretic peptide, soluble tumorgenicity suppressor-2, Galectin-3, Growth differentiation factor-15, C-terminal Propeptide of Type I Collagen (CICP)). (Source: T...
Source: The American Journal of Cardiology - June 12, 2021 Category: Cardiology Authors: D.H. Frank Gommans, G. Etienne Cramer, Michael A. Fouraux, Sanne Heijmans, Michelle Michels, Janneke Timmermans, Freek W.A. Verheugt, Rudolf A. de Boer, Marcel J.M. Kofflard, Marc A. Brouwer Source Type: research

Anisocytosis Is Associated With Reduced Bone Marrow Activity Evaluated by Positron Emission Tomography
Anisocytosis or increased red blood cell distribution width (RDW) has been associated with an elevated cardiovascular risk, especially in patients with coronary artery disease and heart failure.1,2 Anisocytosis has been linked with markers of systemic inflammation, oxidative stress, and iron metabolism.3 However, the mechanism linking RDW with cardiovascular outcomes remains unknown. We assessed the association of vascular, bone marrow, and spleen positron emission tomography (PET) imaging variables with RDW. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Scott E. Janus, Sadeer G. Al-Kindi, Jamal Hajjari, Tarek Chami, Ann Avery, Danielle Labbato, Cheryl Smith, Claire Sullivan, Corrilynn O. Hileman, Grace A. McComsey Source Type: research

Drug Adherence and Long-Term Outcomes in Non-Revascularized Patients Following Acute Myocardial Infarction
This study examined long-term outcomes and adherence to guideline-based medications in non-revascularized acute myocardial infarction (MI) patients undergoing and not undergoing angiography. We analyzed non-revascularized MI patients hospitalized in Alberta, Canada between 2010 –2016 and categorized them according to whether they had undergone coronary angiography. Adherence to guideline-based medications was determined by the proportion of days covered (PDC) and subdivided into categories based on PDC: 0% (none), 1-40% (low), 40-79% (intermediate) and ≥ 80% (high). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Razi Khan, Padma Kaul, Sunjidatul Islam, Anamaria Savu, Akshay Bagai, Sean van Diepen, Kevin R. Bainey, Robert C. Welsh, Shaun G. Goodman Source Type: research

Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales
We investigated the incidence,  management, and outcomes of acute myocardial infarction (AMI) patients according to cardiac arrest location. Patients admitted with a diagnosis of AMI between January 1, 2010 to March 31, 2017 from the Myocardial Ischaemia National Audit Project (MINAP) were studied. We used logistic regression mo dels to evaluate predictors of the clinical outcomes and treatment strategy. The study population consisted of 580,796 patients admitted with AMI stratified into three groups: out of hospital cardiac arrest (OOHCA) (16,278[2.8%]), in-hospital cardiac arrest (IHCA) (21,073[3.7%])...
Source: The American Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Mohamed Dafaalla, Muhammad Rashid, Clive Weston, Tim Kinnaird, Hitinder Gurm, Clare Appleby, Ahmad Shoaib, Chris Stevens, Chadi M Alraies, Nick Curzen, Mamas A. Mamas Source Type: research

Incidence, Predictors, and Prognostic Impact of Immediate Improvement in Left Ventricular Systolic Function After Transcatheter Aortic Valve Implantation
Immediate improvement in left ventricular ejection fraction (LVEF) following transcatheter aortic valve implantation (TAVI) is common; however, data on the pattern and prognostic value of this improvement are limited. To evaluate the incidence, predictors, and clinical impact of immediate improvement in LVEF, we studied 694 consecutive patient who had underwent successful TAVI for severe aortic stenosis (AS) between March 2010 and December 2019. We defined immediate improvement of LVEF as an absolute increase of ≥5% in LVEF at post-procedure echocardiogram. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Yeong Jin Jeong, Jung-Min Ahn, Do-Yoon Kang, Hanbit Park, Euihong Ko, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Seung-Ah Lee, Seung-Jung Park, Dae-Hee Kim, Duk-Woo Park Tags: Valvular Heart Disease Source Type: research

Long-Term Prognostic Significance of Ventricular Repolarization Dispersion in Patients with Cardiac Sarcoidosis
Cardiac sarcoidosis (CS) is frequently complicated by fatal ventricular arrhythmias. T-peak to T-end interval to QT interval ratio (TpTe/QT) on electrocardiograms (ECG) was proposed as a marker of ventricular repolarization dispersion. Although this ratio could be associated with the incidence of ventricular arrhythmias in cardiovascular diseases, its prognostic implication in patients with CS is unclear. We sought to investigate whether TpTe/QT was associated with long-term clinical outcomes in patients with CS. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Yuta Kobayashi, Toshiyuki Nagai, Sakae Takenaka, Yoshiya Kato, Hirokazu Komoriyama, Nobutaka Nagano, Kiwamu Kamiya, Takao Konishi, Takuma Sato, Kazunori Omote, Shingo Tsujinaga, Hiroyuki Iwano, Kengo Kusano, Satoshi Yasuda, Hisao Ogawa, Hatsue Ishibashi-U Source Type: research

Prognostic Impact of Branch Vessel Involvement on Computed Tomography versus Clinical Presentation of Malperfusion in Patients With Type a Acute Aortic Dissection
Type A acute aortic dissection (AAD) is a life-threatening disease. The use of contrast-enhanced computed tomography (CT) for diagnosing AAD has increased, and CT can provide pathophysiologic information on dissection such as intramural hematoma (IMH), longitudinal extent of dissection, and branch vessel involvement. However, the prognostic impact of these CT findings is poorly investigated. This multicenter registry included 703 patients with type A AAD. The longitudinal extent of dissection and IMH was determined on CT. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 11, 2021 Category: Cardiology Authors: Osamu Hashimoto, Yuichi Saito, Takashi Nakayama, Shinichi Okino, Yoshiaki Sakai, Yoshitake Nakamura, Shigeru Fukuzawa, Toshiharu Himi, Iwao Ishibashi, Yoshio Kobayashi Source Type: research

MAUDE Database Analysis of Post-Approval Outcomes following Left Atrial Appendage Closure with the Watchman Device
The objective of this study was to determine the frequency and timing of adverse events associated with Watchman LAAC device implants performed after FDA approval. Adverse events associated with Watchman LAAC implants performed between March 2015 and March 2019 were identified through a search of the FDA Manufacturer and User Facility Device Experience (MAUDE) database. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 8, 2021 Category: Cardiology Authors: Pablo A. Ledesma, Uwajachukwumma A. Uzomah, Xuejing Yu, Ayman Shaqdan, Pegah Khaloo, Jennifer Galvin, Moussa Mansour, Leon M. Ptaszek, Jeremy N. Ruskin Source Type: research

Transcatheter Mitral Valve Repair and Mitral Valve Surgery Following Acute Myocardial Infarction (Insights From a Nationwide Cohort Study)
Transcatheter mitral valve (MV) repair with MitraClip (Abbott Vascular, Santa Clara, California) is an established treatment in patients with severe mitral regurgitation (MR) at inoperable or high surgical risk. Acute ischemic MR can occur due to leaflet tethering or papillary muscle dysfunction secondary to acute myocardial infarction (AMI), leading to cardiogenic shock or congestive heart failure.1-3 While MV surgery has been the mainstay for acute ischemic MR refractory to medical treatment,1 recent reports have shown the feasibility of MitraClip in selected patients with acute/subacute MR following AMI. (Source: The Am...
Source: The American Journal of Cardiology - June 7, 2021 Category: Cardiology Authors: Toshiaki Isogai, Anas M Saad, Manpreet Kaur, Shashank Shekhar, Mohamed M Gad, Rhonda L Miyasaka, Shinya Unai, Daniel JP Burns, Amar Krishnaswamy, Samir R Kapadia Source Type: research

Triglyceride –Rich Lipoproteins, Apolipoproteins, and Atherosclerotic Cardiovascular Events Among Patients with Diabetes Mellitus and End–Stage Renal Disease on Hemodialysis
Hypertriglyceridemia may be implicated in the high atherosclerotic cardiovascular disease (ASCVD) risk experienced by patients with end –stage renal disease (ESRD). In this post–hoc analysis of the “Die Deutsche Diabetes Dialyse Studie (4D)” clinical trial, we examined incident ASCVD events, defined as myocardial infarction, ischemic stroke, or a coronary revascularization procedure, among 1255 participants with type 2 diabe tes and ESRD treated with hemodialysis. Cox–regression methods were used to evaluate the association of triglycerides, very–low density lipoprotein cholesterol (VLDL...
Source: The American Journal of Cardiology - June 6, 2021 Category: Cardiology Authors: Julio A. Lamprea –Montealegre, Ronit Katz, Hubert Scharnagl, Günther Silbernagel, Winfried März, Christiane Drechsler, Cristoph Wanner, Ian H. de Boer Source Type: research

Comments on “Risk Factors for Left Ventricle Enlargement in Children With Frequent Ventricular Premature Complexes” by Bo Chen et al, June 2020
With interest we have read the article of Bo Chen et al., “Risk Factors for Left Ventricle Enlargement in Children With Frequent Ventricular Premature Complexes”, in the American Journal of Cardiology in June 2020. The authors describe a series of pediatric patients with frequent ventricular premature complexes (VPC) with or without asymptomatic ventri cular tachycardia (VT). Data regarding frequent VPCs and VTs in pediatric patients is scarce, therefore new data on this subject is potentially very valuable. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 6, 2021 Category: Cardiology Authors: Robin Andrew Bertels, Lisette M. Harteveld, Nico A. Blom Source Type: research

Pre-Operative Cardiovascular Testing before Liver Transplantation
End-stage liver disease (ESLD) is increasingly prevalent and shares many risk factors with coronary artery disease (CAD). No specific guidelines exist for pre-liver transplant evaluation of CAD, and pretransplant cardiovascular testing varies widely. The aim of this study is to characterize pre-transplant cardiac testing practices with post-transplant clinical outcomes. We retrospectively reviewed patients undergoing initial liver transplantation at our transplant center between January 2015 and March 2019. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 5, 2021 Category: Cardiology Authors: Brian C. Case, Michael Yang, Syed Z. Qamer, Sant Kumar, Charan Yerasi, Brian J. Forrestal, Chava Chezar-Azerrad, Giorgio A. Medranda, Nelson L. Bernardo, Toby Rogers, Lowell F. Satler, Hayder Hashim, Rohit S. Satoskar, Alexander T. Lalos, Ron Waksman, Its Source Type: research

Early Implantable Cardioverter –Defibrillator After Acute Myocardial Infarction
Implantable cardioverter –defibrillator (ICD) therapy has shown to improve survival among patients at high risk of sudden death. Whether this benefit is seen in patients early after myocardial infarction (MI) remains controversial. We performed a systematic review and meta-analysis of randomized controlled trials aimed to assess the survival benefit of early ICD implantation ( (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 5, 2021 Category: Cardiology Authors: Kuldeep Shah, Siddharth Shah, Mohit K. Turagam, Rahul Bhardwaj, Tahmeed Contractor, Ravi Mandapati, Andrea Natale, Dhanunjaya Lakkireddy, Jalaj Garg Source Type: research

Substance Use and Premature Atherosclerotic Cardiovascular Disease (From the CDC Behavioral Risk Factor Surveillance System [BRFSS] Survey)
Substance use (SU) affects a significant number of individuals globally. More recently, national statistics showed that 13.3% of the U.S. population recently initiated or increased SU to cope with stress during the COVID-19 pandemic, with young adults being at higher risk (24.7% and 19.5% of those aged 18-24 and 25-44 years, respectively.).1 The association of SU and atherosclerotic cardiovascular disease (ASCVD) is well-described in the literature.2 Given the prevalence of SU in the young population, we examined the association of SU and premature ASCVD. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 5, 2021 Category: Cardiology Authors: Marilyne Daher, Mahmoud Al Rifai, Dhruv Mahtta, Chayakrit Krittanawong, Jeffrey Berman, Waqas Ullah, Mahboob Alam, Salim S Virani Tags: Reader's Comments Source Type: research

Reader's Comments Association of Peri-Procedural Major Bleeding With Outcomes in Patients Undergoing Transcatheter Mitral Edge-To-Edge Repair
Transcatheter edge-to-edge repair (TEER) is a well-established minimally invasive treatment option for patients with significant degenerative or functional mitral regurgitation (MR).1 Major bleeding (MB) after percutaneous interventional cardiac procedures is an important predictor of adverse short and long-term outcomes. Data from the National Cardiovascular Database Registry (NCDR) show that MB is the most common procedural complication in patients undergoing TEER, with a reported prevalence of approximately 4%. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 3, 2021 Category: Cardiology Authors: Salik Nazir, Tanush Gupta, Keerat Rai Ahuja, Abdul Mannan Khan Minhas, Robert W. Ariss, Rajesh Gupta, Sachin S. Goel, Neal S. Kleiman Source Type: research

Editorial Board
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 2, 2021 Category: Cardiology Source Type: research

Contents
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 2, 2021 Category: Cardiology Source Type: research

Impact of Atrial Fibrillation on Hospitalization Outcomes of Heart Failure in Patients ≥ 60 Years with Implantable Cardioverter Defibrillator
The impact of atrial fibrillation (AF) on the hospitalization outcomes in patients ≥ 60 years of age with implantable cardioverter defibrillators (ICD) is not well studied. We queried the National Inpatient Sample database for all patients aged ≥ 60 who had a history of ICD placement, and were admitted with a primary diagnosis of heart failure (HF) during the years 2016-2017. Patients were stratified into 2 groups based on their history of AF. The primary outcome of the study was all-cause in-hospital mortality. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 2, 2021 Category: Cardiology Authors: Ashraf Abugroun, Ahmed Elawad, Alexis K. Okoh, Manar E. Abdel-Rahman, Hakeem Ayinde, Annabelle Santos Volgman Source Type: research

Meta-analysis of the Safety and Efficacy of the Sentinel Cerebral Protection System in Transcatheter Aortic Valve Implantation
Despite recent advances in transcatheter aortic valve implantation (TAVI), cerebrovascular events (CVE) remain one of the most feared complications of the procedure adversely affecting morbidity and mortality. Several imaging studies showed most of the CVEs after TAVI have a probable embolic etiology from debris during the procedure. It is also hypothesized that patients can develop long-term neurocognitive dysfunction following TAVI due to these emboli.1 As TAVI expands to younger and lower risk patients, the prevention of stroke plays an increasingly important role. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 29, 2021 Category: Cardiology Authors: Yasser Radwan, Abdullah Al-abcha, Mohammad Fahad Salam, Si Yuan Khor, Rohan Madhu Prasad, Ahmed Elshafie, George Abela Source Type: research

Left Bundle Branch Block and Mortality in COVID-19 Patients
The prevalence of left bundle branch block (LBBB) in general population is commonly low but its prevalence significant increase in patients with chronic heart failure (HF) [1]. Recent analyses have demonstrated that COVID-19 patients have a significant incidence of acute HF while those with a history of chronic HF are prone to developing acute decompensation. Moreover, these patients frequently develop acute present cardiac injuries which significantly increase the risk of death during the infection [2]. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 28, 2021 Category: Cardiology Authors: Marco Zuin, Gianluca Rigatelli, Loris Roncon, Giovanni Zuliani Source Type: research

New Heart Failure After Myocardial Infarction (From the National Cardiovascular Data Registries [NCDR] Linked With All-Payer Claims)
Coronary artery disease and heart failure (HF) are in the most common causes of hospitalization and death worldwide.1,2 Coronary artery disease itself is a major risk factor for HF, which may develop through mechanisms including acute myocardial injury with myocyte stunning, necrosis and remodeling, and microvascular dysfunction.3 In those hospitalized with acute myocardial infarction (MI), incidence of HF at the time of MI varies from 14% to 36% and is associated with increased mortality.4 However, risk of HF following hospital discharge for MI patients without preceding or concurrent HF is less well characterized. (Sourc...
Source: The American Journal of Cardiology - May 27, 2021 Category: Cardiology Authors: Kamil F. Faridi, Narinder Bhalla, Nipun Atreja, John Venditto, Naeem D. Khan, Thomas Wilson, Eileen Fonseca, Changyu Shen, Robert W. Yeh, Eric A. Secemsky Source Type: research

Impact of Patient Prosthesis Mismatch on the Outcome of Transcatheter Pulmonic Valve Implantation
Patient prosthesis mismatch (PPM) is an important factor of the outcome in transcatheter aortic valve implantation. However, the impact of PPM in transcatheter pulmonic valve implantation (TPVI) has not been studied. Based on the narrowest valve stent diameters in two views of fluoroscopy, internal geometric orifice area (GOA) of the valve stent was calculated and indexed by body surface area (BSA), deriving iGOA. To define PPM in TPVI, receiver operating characteristics (ROC) curve analysis for iGOA for predicting significant residual right ventricular outflow tract (RVOT) gradient was used to derive the optimal cut-off v...
Source: The American Journal of Cardiology - May 27, 2021 Category: Cardiology Authors: Daiji Takajo, Thomas J Forbes, Daisuke Kobayashi Source Type: research

Prevalence of Left Ventricular Hypertrophy Caused by Systemic Hypertension Preceding the Development of Severe Aortic Stenosis
It is generally assumed that left ventricular (LV) hypertrophy in aortic stenosis (AS) is a compensatory adaptation to chronic outflow obstruction. The advent of transcutaneous aortic valve replacement has stimulated more focus on AS in older patients, most of whom have antecedent hypertension. Accordingly, our aim was to investigate the interaction between hypertension and AS on LV remodeling in contemporary practice. We studied consecutive patients referred for echocardiograms with initial aortic valve (AV) peak velocity3.5 m/s on a subsequent study performed at least 5 years later. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 26, 2021 Category: Cardiology Authors: Summer Aldrugh, Jorge Escobar Valle, Matthew W. Parker, Colleen M. Harrington, Gerard P. Aurigemma Source Type: research

Hemodynamic Profiles of Shock in Patients with COVID-19
Patients with serious COVID infections develop shock frequently. To characterize the hemodynamic profile of this cohort, 156 patients with COVID pneumonia and shock requiring vasopressors had interpretable echocardiography with measurement of ejection fraction (EF) by Simpson's rule and stroke volume (SV) by Doppler. RV systolic pressure (RVSP) was estimated from the tricuspid regurgitation peak velocity. Patients were divided into groups with low or preserved EF (EFL or EFP, cutoff ≤45%), and low or normal cardiac index (CIL or CIN, cutoff ≤2.2 L/min/m2). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Steven M Hollenberg, Lucy Safi, Joseph E Parrillo, Matthew Fata, Brent Klinkhammer, Noha Gayed, Taya Glotzer, Ronaldo C. Go, Elli Gourna-Paleoudis, David Landers, Sameer Jamal, Neel Shah, Roshan Shah, Jana Tancredi, Zoltan G Turi Source Type: research

Usefulness of Left Atrial Strain to Predict End Stage Renal Failure in Patients With Chronic Kidney Disease
Left atrial (LA) enlargement predicts adverse cardiovascular events in patients with chronic kidney disease (CKD). The aim of our study was to evaluate the value of LA reservoir strain, a novel measure of LA function, as a prognostic marker for adverse renal outcomes. A total of 280 patients (65.8 ± 12.2years, 63% male) with stable Stage 3 and 4 CKD without prior cardiac history were evaluated with transthoracic echocardiography and prospectively followed for up to 5 years. The primary end point was progressive renal failure, which was the composite of death from renal cause, end-stage renal failure and/or doubling ...
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Gary C.H. Gan, Aditya Bhat, Krishna K. Kadappu, Fernando Fernandez, Kennith H. Gu, Henry H.L. Chen, Suzanne Eshoo, Brian Nankivell, Liza Thomas Source Type: research

Impact of Body Composition Indices on Ten-year Mortality After Revascularization of Complex Coronary Artery Disease (From the Syntax Extended Survival Trial)
Numerous studies have demonstrated a paradoxical association between higher baseline body mass index (BMI) and lower long-term mortality risk after coronary revascularization, known as the “obesity paradox”, possibly relying on the single use of BMI. The current study is a post-hoc analysis of the SYNTAX Extended Survival (SYNTAXES) trial, which is the extended follow-up of the SYNTAX trial comparing percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CAB G) in patients with left-main coronary artery disease (LMCAD) or three-vessel disease (3VD). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Masafumi Ono, Hideyuki Kawashima, Hironori Hara, Neil O'Leary, Chao Gao, Rutao Wang, Kuniaki Takahashi, Joanna J. Wykrzykowska, Jan J. Piek, Michael J. Mack, David R. Holmes, Marie-Claude Morice, Stuart J. Head, Arie Pieter Kappetein, Daniel J.F.M. Thuijs Source Type: research

Meta-Analysis Comparing the Effect of Combined Omega-3  + Statin Therapy Versus Statin Therapy Alone on Coronary Artery Plaques
Statin therapy plays an important role in stabilizing and regressing coronary artery plaques. Omega-3 supplements also have anti-inflammatory and antioxidant effects on coronary plaques. However, the effect of omega-3 supplementation on the basis of statin therapy on the stability and composition of plaques, is still unclear. We searched for randomized controlled trials published prior to November 2020 in the PubMed, Embase and Cochrane databases. Finally, eight studies using different imaging techniques to evaluate coronary atherosclerotic plaque, including optical coherence tomography (OCT), coronary CT angiography (cCTA...
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Heze Fan, Juan Zhou, Zuyi Yuan Source Type: research

Meta-Analysis of Duration of Dual Antiplatelet Therapy in Acute Coronary Syndrome Treated With Coronary Stenting
We aimed to evaluate if a shorter course of DAPT followed by P2Y12 inhibitor monotherapy is as effective as a 12-month course with fewer bleeding events. PubMed, Scopus, and Cochrane Central were searched for randomized controlled trials of ACS patients comparing dual antiplatelet therapy (DAPT) for 1 to 3 months followed by a P2Y12 inhibitor to 12-month DAPT. Quality assessment was performed with the Cochrane Collaboration risk of bias assessment tool. Five randomized clinical trials were included, with a total of 18,046 participants. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Leonardo Knijnik, Marcelo Fernandes, Manuel Rivera, Rhanderson Cardoso, Abhinav Goyal, Henry Liberman, Laurence S. Sperling, Michael C. McDaniel Source Type: research

Determinants of Exercise-Induced Mitral Regurgitation Using Three-Dimensional Transesophageal Echocardiography Combined With Isometric Handgrip Exercise
Using three-dimensional (3D) transesophageal echocardiography (TEE) and isometric handgrip exercise (IHE), we investigated the determinants of exercise-induced mitral regurgitation (MR) according to MR etiologies. Seventy-six patients with more than moderate MR, 40 patients with functional MR (FMR) and 36 patients with degenerative MR (DMR), underwent 3D TEE combined with IHE. Mitral valve (MV) geometry and 3D vena contracta area (3D VCA) were simultaneously evaluated at baseline and during IHE. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 25, 2021 Category: Cardiology Authors: Yu Harada, Hiroto Utsunomiya, Hitoshi Susawa, Kosuke Takahari, Hajime Takemoto, Yusuke Ueda, Kanako Izumi, Kiho Itakura, Takayuki Hidaka, Yukiko Nakano Source Type: research

Prescribing Trend of Inappropriate Medications in Outpatient Clinics for Older Adults With Heart Failure in the United States: NAMCS 2012 to 2016
Heart failure (HF) is a serious chronic condition affecting older people globally. In 2016, the American Heart Association (AHA) highlighted drugs that may cause or exacerbate HF to assist healthcare providers.1 Previous studies have investigated the prescribing pattern of HF-exacerbating medications among older adults in hospital-based practices,2 the prevalence of HF-exacerbating medication use among ambulatory adult patients based on the National Health and Nutrition Examination Survey,3 and the prevalence of prescribing potentially harmful medications to Medicare patients with HF. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 24, 2021 Category: Cardiology Authors: Masaki Kobayashi, Min Ji Kwak, David Aguilar, Parag Goyal, Holly M. Holmes, Ashish A. Deshmukh, Rajender R. Aparasu Source Type: research

Myocardial Work, an Echocardiographic Measure of Post Myocardial Infarct Scar on Contrast-Enhanced Cardiac Magnetic Resonance
This study investigates the relation of non-invasive myocardial work and myocardial viability following ST-segment elevation myocardial infarction (STEMI) assessed on late gadolinium contrast enhanced cardiac magnetic resonance (LGE CMR) and characterizes the remote zone using non-invasive myocardial work parameters. STEMI patients who underwent primary percutaneous coronary intervention (PCI) were included. Several non-invasive myocardial work parameters were derived from speckle tracking strain echocardiography and sphygmomanometric blood pressure, e.g.: myocardial work index (MWI), constructive work (CW), wasted work (W...
Source: The American Journal of Cardiology - May 23, 2021 Category: Cardiology Authors: Mohammed El Mahdiui, Pieter van der Bijl, Rachid Abou, Rodolfo de Paula Lustosa, Rob van der Geest, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax Source Type: research

Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern
Irritable bowel syndrome (IBS) is one of the most widely recognized functional bowel disorders (FBDs) with a genetic component. SCN5A gene and SCN1B loci have been identified in population-based IBS cohorts and proposed to have a mechanistic role in the pathophysiology of IBS. These same genes have been associated with Brugada syndrome (BrS). The present study examines the hypothesis that these two inherited syndromes are linked. Prevalence of FBDs over a 12 months period were compared between probands with BrS/drug-induced type 1 Brugada pattern (DI-Type 1 BrP) (n  = 148) and a control group (n = 124) matched for ...
Source: The American Journal of Cardiology - May 23, 2021 Category: Cardiology Authors: Anil S. Sarica, Serhat Bor, Mehmet N. Orman, Hector Barajas-Martinez, Jyh-Ming Jimmy Juang, Charles Antzelevitch, Can Hasdemir Source Type: research

One-Year Outcomes After Treatment of Ostial In-Stent Restenosis in Left Circumflex Versus Left Anterior Descending or Right Coronary Artery
The prognosis of left circumflex (LC) versus non-LC in-stent restenosis (ISR) ostial lesions following treatment has not been assessed. We aimed to assess this prognosis. Anecdotally, treatment of ostial LC ISR has been associated with high recurrence rates. We performed a retrospective analysis of patients from our institution who underwent coronary intervention of an ostial ISR lesion between 2003 and 2018. The primary endpoint was target lesion revascularization (TLR) and major adverse cardiovascular events (MACE). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 21, 2021 Category: Cardiology Authors: Chava Chezar-Azerrad, Anees Musallam, Corey Shea, Cheng Zhang, Rebecca Torguson, Charan Yerasi, Brian C. Case, Brian J. Forrestal, Nauman Khalid, Jaffar M. Khan, Evan Shlofmitz, Yuefeng Chen, Lowell F. Satler, Nelson L. Bernardo, Itsik Ben-Dor, Toby Roger Source Type: research

Hospital Readmission in Patients With Spontaneous Coronary Artery Dissection
Spontaneous coronary artery dissection (SCAD) can present with various clinical symptoms, including chest pain, syncope, and sudden cardiac death, particularly in those without atherosclerotic risk factors. In this contemporary analysis, we aimed to identify the causes and predictors of 30-day hospital readmission in SCAD patients. We utilized the latest Nationwide Readmissions Database from 2016 - 2017 to identify patients with a primary discharge diagnosis of SCAD. The primary outcome was 30-day readmission. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 21, 2021 Category: Cardiology Authors: Chayakrit Krittanawong, Bing Yue, Dhruv Mahtta, Anirudh Kumar, Scott Kaplin, Hafeez Ul Hassan Virk, Zhen Wang, Hani Jneid, Deepak L. Bhatt Source Type: research

Cannabis Use and Electrocardiographic Myocardial Injury
Multiple observational studies have demonstrated an association with cannabis use and acute myocardial infarction, especially among young adults. However, little is known about the connection with subclinical or electrocardiographic myocardial injury. We hypothesized that cannabis use would be associated with an increased risk of myocardial injury as defined by the cardiac infarction and/or injury score (CIIS). This analysis included 3,634 (age 48.0 ± 5.9 years, 47.1% male, 68.7% Caucasians) participants from the Third National Health and Examination Survey. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 20, 2021 Category: Cardiology Authors: Travis M. Skipina, Bharathi Upadhya, Elsayed Z. Soliman Source Type: research

Accuracy of the “Thumb-Palm Test” for Detection of Ascending Aortic Aneurysm
We have noticed, in caring for thousands of patients with ascending aortic aneurysm (AscAA), that the “thumb palm test” is often positive (with the thumb crossing beyond the edge of the palm). It is not known how accurate this test may be. We conducted the thumb-palm test in 305 patients undergoing cardiac surgery with intra-operative transesophageal echocardiography (TEE) for a variety of disor ders: ascending aneurysm in 59 (19.4%) and non-AscAA disease in 246 (80.6%) (including CABG, valve repair, and descending aortic aneurysm). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 18, 2021 Category: Cardiology Authors: Rachel Blumel, Kanchi Patel, John A. Rizzo, Salvior Mok, Annie Barrett, Jinlin Wu, Mohammad A. Zafar, Bulat A. Ziganshin, John A. Elefteriades Source Type: research

Detection of Mechanical Prosthetic Valve Dysfunction
The long-term outcome of mechanical aortic and mitral prosthetic valve (A-PV, M-PV) dysfunction (PVD) remains a serious complication associated with high morbidity and mortality. We sought to evaluate the incremental diagnostic value of combined transthoracic echocardiography (TTE) and fluoroscopy (F) in patients with suspected PVD. A total of 354 patients (178 A-PV, 176 M-PV) were imaged by TTE and F within 5 days of hospital admission. PVD was confirmed by transesophageal echocardiography, computed tomography, effective thrombolysis, or surgical inspection. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 18, 2021 Category: Cardiology Authors: Manuela Muratori, Laura Fusini, Sarah Ghulam Ali, Giovanni Teruzzi, Nicoletta Corrieri, Paola Gripari, Massimo Mapelli, Andrea Annoni, Gloria Tamborini, Mark G. Rabbat, Gianluca Pontone, Francesco Alamanni, Piero Montorsi, Mauro Pepi Source Type: research

Usefulness of Alcohol Septal Ablation in the Left Ventricular Outflow Tract Obstruction in Fabry Disease Cardiomyopathy
We describe 6 male patients with genetically confirm ed FD and symptomatic LVOTO. All of them underwent a transcatheter alcohol septal ablation with an immediate effect on the obstruction in all cases and without any serious complications. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: David Zem ánek, Josef Marek, Gabriela Dostálová, Sudheera Magage, Lenka Roblová, Tomáš Kovárník, Aleš Linhart Source Type: research

Meta-Analysis Comparing Same-Sitting and Staged Percutaneous Coronary Intervention of Non-Culprit Artery for ST-Elevation Myocardial Infarction with Multivessel Coronary Disease
Recent trials and meta-analysis have indicated that complete revascularization (CR) of multivessel coronary disease is beneficial in patients with ST-segment elevation myocardial infarction (STEMI) compared to culprit-only intervention. However, the optimal timing of CR remains unclear. We aimed to analyze the optimal timing of CR in patients with STEMI and multivessel disease by performing an updated network meta-analysis using the recent largest randomized controlled trial. PUBMED and EMBASE were searched through October 2020 to identify randomized controlled trials comparing CR and culprit-only revascularization. (Sourc...
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: Hiroki Ueyama, Toshiki Kuno, Keisuke Yasumura, Yuliya Vengrenyuk, Hisato Takagi, Nitin Barman, Javed Suleman, Amerjeet Singh Banning, Bianca M. Boxma-de Klerk, Pieter C. Smits, Annapoorna Kini, Samin K. Sharma Source Type: research

Prevalence, Incidence and Prognostic Implications of Left Bundle Branch Block in Patients with Chronic Coronary Syndromes (From the CLARIFY Registry)
Left Bundle Branch Block (LBBB) is a frequently encountered electrical abnormality in patients with chronic (more than 3 months after myocardial infarction, or evidence of coronary artery disease with ischemia) coronary syndromes (CCS), but its prognostic significance remains unclear. We aimed to describe the prevalence, incidence and five-year outcomes of LBBB in outpatients with CCS using the CLARIFY registry. Main outcome was a composite of CV death, MI or stroke. Secondary outcomes included all cause death, hospitalization for heart failure (HF) and permanent pacemaker implantation. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: Arthur Darmon, Gregory Ducrocq, Yedid Elbez, Batric Popovic, Emmanuel Sorbets, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg, CLARIFY Investigators Source Type: research

P2Y12 Inhibitor Monotherapy Versus Conventional Dual Antiplatelet Therapy or Aspirin Monotherapy in Acute Coronary Syndrome: A Pooled Analysis of the SMART-DATE and SMART-CHOICE Trials
This study sought to investigate the efficacy and safety of P2Y12 inhibitor monotherapy compared with conventional dual antiplatelet therapy (DAPT) and aspirin monotherapy in patients with ACS undergoing percutaneous coronary intervention. Data on 4,453 patients were pooled from SMART-DATE and SMART-CHOICE randomized trials. Antiplatelet therapy regimens were categorized as P2Y12 inhibitor monotherapy (P2Y12 inhibitor monotherapy after 3-month DAPT), conventional DAPT (12-month or longer DAPT), and aspirin monotherapy (aspirin monotherapy after 6-month DAPT). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: Pil Sang Song, Yong Hwan Park, Ju-Hyeon Oh, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Deok-Kyu Cho, Seung-Woon Rha, Jang-Whan Bae, Jin-Ok Jeong, Joo-Yong Hahn, for the SMART-DATE and the SMART-CHOICE investigators Source Type: research

Association of Peri-Procedural Major Bleeding With Outcomes in Patients Undergoing Percutaneous Left Atrial Appendage Closure
Percutaneous left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) is indicated for reduction of thromboembolic risk in patients with non-valvular atrial fibrillation who are poor candidates for long-term oral anticoagulation. The procedure is performed via femoral venous access using a 14 F sheath. Data from the pivotal randomized controlled trials and real-world clinical practice have shown that major bleeding in the procedural setting remains one of the most common complications of LAAC (1.5% to 3.5%). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 16, 2021 Category: Cardiology Authors: Salik Nazir, Keerat Rai Ahuja, Abdul Mannan Khan Minhas, Robert W. Ariss, Sachin S. Goel, Rajesh Gupta Source Type: research

Reply to “Simple Methods for Predicting Cardiovascular Readmission After a Heart Failure Hospitalization”
We thank Dr. Tomoyuki Kawada for his comments on our recent article.1,2 Dr. Kawada's suggestion about conducting the analyses using Cox proportional hazards models to generate hazard ratios is a reasonable alternative approach. We chose to conduct a multinomial logistic regression in large part because we aimed to concurrently examine multiple outcomes including cardiovascular and noncardiovascular readmission (compared to no readmission). Although time-to-event could potentially add to the findings here, we would argue that 30-day readmission is an untoward event with important implications on cost, morbidity, and quality...
Source: The American Journal of Cardiology - May 15, 2021 Category: Cardiology Authors: Aayush Visaria, Laura C. Pinheiro, Madeline R. Sterling, Parag Goyal Source Type: research

Predictive Value of Abdominal Fat Distribution on Coronary Artery Disease Severity Stratified by Computed Tomography-Derived SYNTAX Score
This study aimed to evaluate the association between abdominal fat distribution (AFD) and coronary artery disease (CAD) complexities using the computed tomography (CT)-derived SYNTAX score (CT-SXscore). Coronary computed tomographic angiography (CCTA) was performed in patients with suspected CAD. Plain abdominal CT was performed to measure visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas. To assess AFD, VAT/SAT (V/S) ratios were calculated. The CT-SXscore was calculated in patients with significant stenoses assessed by CCTA. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 15, 2021 Category: Cardiology Authors: Kyuhachi Otagiri, Keisuke Machida, Tadashi Itagaki, Takahiro Takeuchi, Yusuke Tsujinaka, Hisanori Yui, Chie Nakamura, Takahiro Sakai, Tamon Kato, Tatsuya Saigusa, Soichiro Ebisawa, Hirohiko Motoki, Koichiro Kuwahara, Hiroshi Kitabayashi Source Type: research

Temporal Trends, Management and Outcomes of Acute Myocardial Infarction with Concomitant Respiratory Infections
There are limited contemporary data on the management and outcomes of acute myocardial infarction (AMI) in patients with concomitant acute respiratory infections. Hence, using the National Inpatient Sample from 2000-2017, adult AMI admissions with and without concomitant respiratory infections were identified. We evaluated in-hospital mortality, utilization of cardiac procedures, hospital length of stay, hospitalization costs, and discharge disposition. Among 10,880,856 AMI admissions, respiratory infections were identified in 745,536 (6.9%). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 15, 2021 Category: Cardiology Authors: Saraschandra Vallabhajosyula, Sri Harsha Patlolla, Dennis H Murphree, Wisit Cheungpasitporn, David R Holme, Bernard J Gersh Source Type: research

Impact of Postprocedural High-Sensitivity C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk with ST-Segment Elevation Myocardial Infarction With Percutaneous Coronary Intervention
This study aimed to investigate the impact of high-sensitivity C-reactive protein (hsCRP) on Lipoprotein(a) [Lp(a)] associated cardiovascular risk in patients with ST-segment elevation myocardial infarction (STEMI) underwent percutaneous coronary intervention (PCI). A total of 2318 STEMI-PCI patients were retrospectively recruited, and further stratified based on postprocedural hsCRP levels ( ≥ 2 vs (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 15, 2021 Category: Cardiology Authors: Ying Wang, Xiaoxiao Zhao, Peng Zhou, Chen Liu, Runzhen Chen, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Li Song, Hanjun Zhao, Hongbing Yan Source Type: research