Effect of Elevated C-Reactive Protein on Outcomes After Complex Percutaneous Coronary Intervention for Angina Pectoris
Inflammation and procedural complexity are individually associated with adverse outcomes after percutaneous coronary intervention (PCI). We aimed to evaluate the association of high sensitivity C-reactive protein (hsCRP) with adverse events according to PCI complexity. We included patients with available hsCRP levels who underwent PCI at our center from 2012 to 2017. We compared patients with hsCRP ≥3 versus60 mm. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 17, 2022 Category: Cardiology Authors: Anton Camaj, Gennaro Giustino, Nikola Kocovic, Davide Cao, Bimmer E. Claessen, Samantha Sartori, Zhongjie Zhang, Hanbo Qiu, Johny Nicolas, Tomoya Hinohara, Usman Baber, David A. Power, Nitin Barman, Joseph Sweeny, George Dangas, Annapoorna Kini, Samin K. Source Type: research

Long-Term Intracoronary Structural and Vasomotor Assessment of the ABSORB Bioresorbable Vascular Scaffold
We systematically categorized the longer-term ( ≥3 years) structural and functional characteristics of the ABSORB bioresorbable vascular scaffold (BVS) using optical coherence tomography imaging and coronary vasomotor reactivity testing and further compared the functional characteristics of BVS stented versus remote coronary segments. A total o f 92 patients (mean age 56.4 ± 9.7 years, 22.8% women) who underwent percutaneous coronary intervention (76% with acute coronary syndrome) using the ABSORB BVS (112 lesions) were included. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 17, 2022 Category: Cardiology Authors: Omar Abdul-Jawad Altisent, Luis Renier Goncalves-Ram írez, Leticia Fernández, David Viladés, Enrique Gutiérrez, Satoru Mitomo, Azeem Latib, Juan Gabriel Córdoba-Soriano, Raquel Adeliño, Ignacio Amat-Santos, Juan Francisco Muñoz, Jaime Elízaga, Hir Source Type: research

Relation of Iron Status to Prognosis After Acute Coronary Syndrome
Iron deficiency has been extensively researched and is associated with adverse outcomes in heart failure. However, to our knowledge, the temporal evolution of iron status has not been previously investigated in patients with acute coronary syndrome (ACS). Therefore, we aimed to explore the temporal pattern of repeatedly measured iron, ferritin, transferrin, and transferrin saturation (TSAT) in relation to prognosis post-ACS. BIOMArCS (BIOMarker study to identify the Acute risk of a Coronary Syndrome) is a prospective, multicenter, observational cohort study conducted in The Netherlands between 2008 and 2015. (Source: The A...
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Muhammed T. G ürgöze, Isabella Kardys, K. Martijn Akkerhuis, Rohit M. Oemrawsingh, Hilde E. Groot, Pim van der Harst, Victor A. Umans, Bas Kietselaer, Eelko Ronner, Timo Lenderink, Folkert W. Asselbergs, Olivier C. Manintveld, Eric Boersma Source Type: research

Relation of Cigarette Smoking and Heart Failure in Adults ≥65 Years of Age (From the Cardiovascular Health Study)
Cigarette smoking is associated with adverse cardiac outcomes, including incident heart failure (HF). However, key components of potential pathways from smoking to HF have not been evaluated in older adults. In a community-based study, we studied cross-sectional associations of smoking with blood and imaging biomarkers reflecting mechanisms of cardiac disease. Serial nested, multivariable Cox models were used to determine associations of smoking with HF, and to assess the influence of biochemical and functional (cardiac strain) phenotypes on these associations. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: John S. Gottdiener, Petra Buzkova, Peter A. Kahn, Christopher DeFilippi, Sanjiv Shah, Eddy Barasch, Jorge R. Kizer, Bruce Psaty, Julius M. Gardin Source Type: research

Relation of Cardiorenal Syndrome to Mitral and Tricuspid Regurgitation in Acute Decompensated Heart Failure
This study aimed to investigate the role of secondary mitral regurgitation (MR) and tricuspid regurgitation (TR) in the pathogenesis of cardiorenal syndrome (CRS). Worsening renal function in patients with acute decompensated heart failure receiving diuretic therapy is defined as CRS and is related to central venous congestion. The role of secondary MR and TR is not well studied. We retrospectively reviewed the electronic medical records of 80 consecutive patients hospitalized with acute decompensated heart failure. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Frank F. Seghatol, Kimberly D. Martin, Ayman Haj-Asaad, Min Xie, Sumanth D. Prabhu Source Type: research

Early Resolution of New-Onset Left Bundle Branch Block After Transcatheter Aortic Valve Implantation With the SAPIEN 3 Valve
New-onset left bundle branch block (LBBB) is common after transcatheter aortic valve implantation (TAVI) but can resolve in the post-TAVI period. We sought to examine the incidence, predictors, and outcomes of early resolution of new-onset LBBB among TAVI recipients with a SAPIEN 3 (S3) valve. Among 1,203 S3-TAVI recipients without a pre-existing pacemaker or wide QRS complex at our institution between 2016 and 2019, we identified 143 patients who developed new-onset LBBB during TAVI and divided them according to the resolution or persistence of LBBB by the next day post-TAVI to compare high-degree atrioventricular block (...
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Toshiaki Isogai, Iryna Dykun, Ankit Agrawal, Shashank Shekhar, Khaldoun G. Tarakji, Oussama M. Wazni, Ankur Kalra, Amar Krishnaswamy, Grant W. Reed, Samir R. Kapadia, Rishi Puri Source Type: research

Relatability of Blood Pressure Monitoring With Wearable Cuffless Devices
Wearable cuffless blood pressure measuring devices, such as smartwatches and other health monitoring devices, are popular because of the ease of wearing them and the wealth of information they provide. It is estimated that approximately 30%, mostly high-income and educated adults, wear such devices in the United States. In addition, recent studies show that these devices are not properly calibrated, and therefore, the information they provide is unreliable. Recent guidelines, like those of the 2018 Association of Advancement of Medical Instrumentation, European Society of Hypertension/International Organization for Standar...
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Steven G. Chrysant Tags: Editorial Source Type: research

The Student Loan Debt Trap: Part I of Many
This Editorial, and the next several, are a review of The Debt Trap: How Student Loans Became a National Catastrophe (Simon& Schuster). Josh Mitchell is an award-winning reporter at The Wall Street Journal. His facts are solid, and his arguments are well-reasoned and compelling but not shrill. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Robert M. Doroghazi Source Type: research

Effects of Antidiabetic Medications on Cardiovascular Outcomes in Patients With Heart Failure
Patoulias et al1 updated the beneficial effects of sodium-glucose co-transporter 2 (SGLT-2) inhibitors in patients with heart failure (HF) by a meta-analysis. Risk ratios (95% confidence intervals [CIs]) of SGLT-2 Inhibitors for the composite of cardiovascular disease (CVD) death or hospitalization for HF, CVD death, and all-cause death were 0.76 (0.72 to 0.81), 0.88 (0.80 to 0.97), and 0.92 (0.85 to 1.00), respectively. SGLT-2 inhibitors had the benefit of risk reduction with regard to hospitalization for HF decompensation and CVD and all-cause death. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Tomoyuki Kawada Source Type: research

Meta-Analysis Assessing the Impact of Previous Heart Failure and Chronic Kidney Disease on the Cardiovascular Efficacy of Glucagon-Like Peptide-1 Receptor Agonists
Chronic kidney disease (CKD) and heart failure (HF) represent common co-morbidities in patients with type 2 diabetes mellitus (T2DM), constituting an additional burden that boosts overall morbidity and mortality.1,2 Recent meta-analyses of relevant cardiovascular outcome trials have confirmed the cardiovascular efficacy of glucagon-like Peptide-1 receptor agonists (GLP-1RAs) in patients with T2DM across several surrogate cardiovascular end points.3,4 Therefore, we sought to determine whether a history of HF or CKD affects the cardiovascular efficacy of GLP-1RAs, also using data from the recently published FREEDOM Cardiovas...
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Dimitrios Patoulias, Christodoulos Papadopoulos, Asterios Karagiannis, Michael Doumas Source Type: research

Outcomes Associated With Cardiac Arrest in Patients in the Cardiac Intensive Care Unit With Cardiogenic Shock
Cardiac arrest (CA) is common and has been associated with adverse outcomes in patients with cardiogenic shock (CS). We sought to determine the prevalence, patient characteristics, and outcomes of CA in cardiovascular intensive care unit patients with CS. We queried cardiovascular intensive care unit admissions from 2007 to 2018 with an admission diagnosis of CS and compared patients with and without CA. Temporal trends were assessed using linear regression. The primary and secondary outcomes of in-hospital and 1-year mortality were analyzed using logistic regression and Cox proportional-hazards analysis, respectively. (So...
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Abdelrahman M. Ahmed, Meir Tabi, Brandon M. Wiley, Saraschandra Vallabhajosyula, Gregory W. Barsness, Malcolm R. Bell, Jacob C. Jentzer Source Type: research

Pandemic-Associated Delays in Myocardial Infarction Presentation in Predominantly Rural Counties With Low COVID-19 Prevalence
Fewer ST-elevation myocardial infarctions (STEMIs) presentations and increased delays in care occurred during the COVID-19 pandemic in urban areas. Whether these associations occurred in a more rural population has not been previously reported. Our objective was to evaluate the impact of COVID-19 on time-to-presentation for STEMI in rural locations. Patients presenting to a large STEMI network spanning 27 facilities and 13 predominantly rural counties between January 1, 2016 and April 30, 2020 were included. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: David A. McNamara, Stacie VanOosterhout, David Klungle, Denise Busman, Jessica L. Parker, Andrew Kampfschulte, Stefan Jovinge, David Wohns, Ryan D. Madder Source Type: research

Ventricular Premature Complexes and Their Associated Factors in a General Population of Japanese Men
Increased ventricular premature complexes (VPCs) are associated with a higher risk of cardiac morbidities. However, little information is available on the risk factors of Western general populations. Therefore, we aimed to assess the frequency and associated factors of VPCs in healthy general Japanese men. We conducted a population-based cross-sectional study in 517 men, aged 40 to 79  years, using 24-hour Holter electrocardiography. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, resting heart rate, diabetes mellitus, hypertension, physical activ...
Source: The American Journal of Cardiology - January 16, 2022 Category: Cardiology Authors: Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura, Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Resea Source Type: research

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality
Previous studies have shown reduced cardiovascular risk with increasing high-density lipoprotein cholesterol (HDL-C) levels. However, recent data in the general population have shown increased risk of adverse outcomes at very high concentrations of HDL-C. Thus, we aimed to study the gender-specific relation between very high HDL-C levels (>80,>100  mg/100 ml) and adverse cardiovascular outcomes and the genetic basis in the general population enrolled in the United Kingdom Biobank. A total of 415,416 participants enrolled in the United Kingdom Biobank without coronary artery disease were included in this pro...
Source: The American Journal of Cardiology - January 14, 2022 Category: Cardiology Authors: Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yan V. Sun, Arshed A. Quyyumi Source Type: research

Editorial Board
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 13, 2022 Category: Cardiology Source Type: research

Contents
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 13, 2022 Category: Cardiology Source Type: research

Management of American Heart Association/American College of Cardiology-Defined Stage 2 Hypertension by Cardiologists in India
This study assessed approaches to the management of patients with Stage 2 hypertension by cardiologists in India.This was a retrospective, multicenter, observational, case-based questionnaire study. Data on demographic characteristics, risk factors associated with Stage 2 hypertension, use of antihypertensive medications, side effects, and approaches to education for 2,540 patients were extracted from questionnaire responses provided by 508 cardiologists. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 13, 2022 Category: Cardiology Authors: C Venkata S Ram, Jamshed Dalal, Dhiman Kahali, Padhinhare P Mohanan, Mrinal Kanti Das, Santanu Guha, Tiny Nair, Calambur Narasimhan, Devanu Ghosh Roy, Jabir Abdullakutty, Soumitra Ray, Mahesh Fulwani, Jagdish Chander Mohan, Rajeev Gupta, Mahesh Abhyankar, Source Type: research

Impact of Race/Ethnicity on Long Term Outcomes After Percutaneous Coronary Intervention with Drug-Eluting Stents
Cardiovascular disease constitutes the leading cause of mortality worldwide, irrespective of race/ethnicity. Previous studies have shown that minority patients with acute coronary syndrome have distinct clinical, anatomic, and socioeconomic characteristics which may affect clinical outcomes. We included patients who underwent percutaneous coronary intervention with drug-eluting stents for ST-segment elevation myocardial infarction (STEMI), non-STEMI, or unstable angina in a single center. Patients were stratified into Caucasian, African-American, Hispanic, and Asian. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 12, 2022 Category: Cardiology Authors: Anastasios Roumeliotis, Bimmer Claessen, Samantha Sartori, Davide Cao, Won-Joon Koh, Hanbo Qiu, Johny Nicolas, Rishi Chandiramani, Ridhima Goel, Mauro Chiarito, Joseph Sweeny, Nitin Barman, Prakash Krishnan, Annapoorna Kini, Samin K Sharma, George Dangas, Source Type: research

Temporal Trends in Use of Complementary Therapies Among Patients With Cardiovascular Disorders
This study aimed to evaluate the use and frequency of complementary and integrative medicine (CIM) therapies in an outpatient cohort with cardiovascular disease (CVD) and compare trends over time. This cross-sectional point-of-care prospective study assessed patients attending a cardiology outpatient clinic. As in our 2009 cohort, data were collected with a 17-question survey on demographic characteristics, CVD history, current use and future interest in CIM. In total, 964 patients completed the survey. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 12, 2022 Category: Cardiology Authors: Kavita Prasad, Abhiram Prasad, Merit George, Gurpreet  S. Sandhu, Jose R. Medina Inojosa, Anjali Bhagra, Saswati Mahapatra, Tanya M. Petterson, Kandace A. Lackore, Ivana T. Croghan, Brent A. Bauer, Dietlind L. Wahner-Roedler Source Type: research

Unraveling the Multitude of Etiologies in Myocardial Infarction With Nonobstructive Coronary Arteries
Although recent studies revealed suboptimal outcomes in patients with myocardial infarction with nonobstructive coronary arteries (MINOCAs), the underlying etiology remains unknown in most patients. Therefore, adequate treatment modalities have not yet been established. We aimed to assess demographics, treatment strategies, and long-term clinical outcome in MINOCA subgroups. We retrospectively analyzed data from a large, prospective observational study of patients with acute coronary syndrome admitted to the Isala hospital in Zwolle, The Netherlands between 2006 and 2014. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 12, 2022 Category: Cardiology Authors: Tobias F.S. Pustjens, Nousjka P.A. Vranken, Renicus S. Hermanides, Saman Rasoul, Jan P. Ottervanger, Arnoud W.J. van ‘t Hof Source Type: research

A Validated Model to Identify Patients With Low Likelihood of High-Risk Coronary Artery Disease Anatomy
In stable coronary artery disease (CAD), revascularization improves outcomes only for patients with high-risk coronary anatomy (HRCA). We sought to derive and validate a prediction model, incorporating clinical and exercise stress test characteristics, to identify patients with HRCA. We conducted a retrospective analysis of patients undergoing exercise stress testing at Cleveland Clinic (2005 to 2014), followed by invasive coronary angiography within 3 months. We excluded patients with acute coronary syndrome, known CAD or ejection fraction (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 11, 2022 Category: Cardiology Authors: Amr F. Barakat, Ram Amuthan, Essa Hariri, Rajdeep Chana, Niyati Gupta, Joseph Ibrahim, Zubair S. Bashir, Bo Hu, Ahmet Sezer, Floyd Thoma, Prem Soman, Suresh Mulukutla, Benico Barzilai, Stephen G. Ellis, Wael Jaber, Michael B. Rothberg Source Type: research

Validation of Heart Failure-Specific Risk Equations in 1.3 Million Israeli Adults and Usefulness of Combining Ambulatory and Hospitalization Data from a Large Integrated Health Care Organization
Heart failure (HF) prevalence is increasing worldwide and is associated with significant morbidity and mortality. Guidelines emphasize prevention in those at-risk, but HF-specific risk prediction equations developed in United States population-based cohorts lack external validation in large, real-world datasets outside of the United States. The purpose of this study was to assess the model performance of the pooled cohort equations to prevent HF (PCP-HF) within a contemporary electronic health record for 5- and 10-year risk. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 11, 2022 Category: Cardiology Authors: Sadiya S. Khan, Noam Barda, Philip Greenland, Noa Dagan, Donald M. Lloyd-Jones, Ran Balicer, Laura J. Rasmussen-Torvik Source Type: research

Usefulness of Combined Renin-Angiotensin System Inhibitors and Diuretic Treatment In Patients Hospitalized with COVID-19
Antecedent use of renin-angiotensin system inhibitors (RASi) prevents clinical deterioration and protects against cardiovascular/thrombotic complications of COVID-19, for indicated patients. Uncertainty exists regarding treatment continuation throughout infection and doing so with concomitant medications. Hence, the purpose of this study is to evaluate the differential effect of RASi continuation in patients hospitalized with COVID-19 according to diuretic use. We used the Coracle registry, which contains data of hospitalized patients with COVID-19 from 4 regions of Italy. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 10, 2022 Category: Cardiology Authors: Alberto Palazzuoli, Kristen M. Tecson, Marco Vicenzi, Fabrizio D'Ascenzo, Gaetano Maria De Ferrari, Silvia Monticone, Gioel G. Secco, Guido Tavazzi, Giovanni Forleo, Paolo Severino, Francesco Fedele, Francesco De Rosa, Peter A. McCullough Source Type: research

Incidence and Predictors of Bleeding in Patients With Cancer and Atrial Fibrillation
This study aimed to assess the incidence and predictors of bleeding in patients with AF and cancer. The study population comprised 16,056 patients from a Spanish health area diagnosed with AF between 2014 and 2018 (1,137 with cancer). Competing risk analysis were used to evaluate the association of cancer and bleeding. Discrimination and calibration of bleeding risk scores were assessed by the concordance statistic and the Brier score, respectively. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 10, 2022 Category: Cardiology Authors: Sergio Raposeiras Roub ín, Emad Abu Assi, Isabel Muñoz Pousa, Pablo Domínguez Erquicia, Maria Melendo Viu, Inmaculada Gonzalez Bermudez, Andrés Íñiguez Romo Source Type: research

Temporal Trends in Diagnostic Testing Patterns for Wild-Type Transthyretin Amyloid Cardiomyopathy in the Medicare Fee-for-Service Population
Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is frequently misdiagnosed or diagnosed late in the disease course. ATTRwt-CM can be diagnosed invasively through tissue biopsy, but current diagnostic recommendations indicate technetium-99m pyrophosphate (99mTc-PYP) bone scintigraphy is an acceptable noninvasive alternative. The relative use of these confirmatory diagnostic tests in routine clinical practice is unknown. A retrospective observational study assessed temporal trends in biopsy and 99mTc-PYP scintigraphy and differences in patient characteristics using in/outpatient claims data from the US Medicare fe...
Source: The American Journal of Cardiology - January 9, 2022 Category: Cardiology Authors: Jamieson M. Bourque, Alexander Schepart, Rahul Bhambri, Adam Casta ño, Alex O'Brien, Yong Chen, Sapna Prasad, Anuja Roy, Justin L. Grodin Source Type: research

Combined Transcatheter Aortic and Mitral Valve Implantation
Transcatheter mitral valve implantation (TMVI) has emerged as a distinct option for patients with severe mitral valvular dysfunction at surgical high or prohibitive risk. The rates of concomitant moderate to severe mitral regurgitation (MR) in patients with severe aortic stenosis who underwent transcatheter aortic valve implantation (TAVI) range from 2% to 33%.1 In high-risk patients with concomitant aortic stenosis and MR, combined TAVI and TMVI may be a feasible approach; however, data on the outcomes of combined TAVI and TMVI are limited to case reports. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 9, 2022 Category: Cardiology Authors: Agam Bansal, Mohamed M. Gad, Medhat Farwati, Grant W. Reed, Rishi Puri, Amar Krishnaswamy, James Yun, Samir R. Kapadia Source Type: research

Long-Term Outcomes for Patients With Acute Coronary Syndrome and Nonvalvular Atrial Fibrillation
Short-term outcomes are worse for patients with acute coronary syndrome (ACS) with a history of nonvalvular atrial fibrillation (NVAF). However, long-term prognosis remains unclear. We linked administrative health databases to identify patients hospitalized with ACS (ST-elevation myocardial infarction [STEMI], non –STEMI [NSTEMI], and unstable angina) between 2008 and 2019 in Alberta, Canada. Patients were stratified according to history of NVAF before hospitalization. The primary outcome was a composite of all-cause mortality, hospitalization for myocardial infarction, or stroke at 3 years. (Source: The America...
Source: The American Journal of Cardiology - January 7, 2022 Category: Cardiology Authors: Pishoy Gouda, Douglas C. Dover, Anamaria Savu, Kevin Bainey, Shaun G. Goodman, Robert Welsh, Padma Kaul, Roopinder Kaur Sandhu Source Type: research

Meta-Analysis of Surgical Left Atrial Appendage Occlusion During Cardiac Surgery
We congratulate Mohamed et  al1 on their meta-analysis of randomized controlled trials (RCTs) comparing surgical left atrial appendage occlusion (LAAO) to no LAAO in patients with atrial fibrillation (AF). The pooled estimate of a 33% reduction in risk of stroke or systemic embolism with LAAO (5 trials, 5,128 patients, risk ratio [RR] 0.67, 95% confidence interval [CI] 0.53 to 0.84, p  (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 5, 2022 Category: Cardiology Authors: Gwen E. Eagle, Richard P. Whitlock, Emilie P. Belley-C ôté Source Type: research

Polygenic Risk Scores for Predicting Adverse Outcomes After Coronary Revascularization
Coronary procedures predispose patients to adverse events. To improve our understanding of the genetic factors underlying postoperative prognosis, we studied the association of polygenic risk scores (PRSs) with postprocedural complications in coronary patients who underwent revascularization. The study sample comprised 8,296, 6,132, and 13,082 patients who underwent percutaneous coronary intervention, coronary artery bypass grafting, or any revascularization, respectively. We genotyped all subjects and identified adverse events during follow-up of up to 30 years by record linkage with nationwide healthcare registers. (Sour...
Source: The American Journal of Cardiology - January 5, 2022 Category: Cardiology Authors: Jenni Aittokallio, Anni Kauko, Felix Vaura, Veikko Salomaa, Tuomas Kiviniemi, FinnGen, Renate B. Schnabel, Teemu Niiranen Source Type: research

Trends and Outcomes of Transcatheter Versus Surgical Aortic Valve Implantation in Patients on Chronic Steroids
Transcatheter aortic valve implantation (TAVI) is a safe and effective alternative to surgical aortic valve replacement (SAVR) in high, intermediate, and low-risk patients with severe, symptomatic aortic stenosis.1 Corticosteroids are among the most widely prescribed drug classes worldwide, with an estimated prevalence of 1.2% in the United States.2 Chronic steroid use is a well-known independent risk factor for perioperative complications. The potential for increased risk of infection, vascular fragility, and delayed wound healing after surgery may increase the risk of complications and adversely impact procedural outcome...
Source: The American Journal of Cardiology - January 4, 2022 Category: Cardiology Authors: Aaqib H. Malik, Jared Slater, Alexandros Briasoulis, Jayakumar Sreenivasan, Syed Zaid, Srikanth Yandrapalli, Syed Abbas Haidry, Gilbert H.L. Tang, Ryan Kaple, Hasan Ahmad Tags: Readers ’ Comments Source Type: research

Acute Kidney Recovery Following Transcatheter Aortic Valve Implantation: A Matter of Definition?
Acute kidney injury (AKI) represents a common complication after aortic valve implantation whose predictors and negative impact on long-term outcomes are well established. Recently, the concept of acute kidney recovery (AKR) after transcatheter aortic valve implantation (TAVI) was proposed. Such a phenomenon is based on the theoretical improvement of renal function following the increase of cardiac output after aortic valve implantation leading to increased renal perfusion and reduced glomerular venous congestion. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 4, 2022 Category: Cardiology Authors: Simone Fezzi, Michele Pighi, Flavio Ribichini Source Type: research

Gender Differences in Age-Stratified Inhospital Outcomes After Transcatheter Aortic Valve Implantation (from the National Inpatient Sample 2012 to 2018)
Contemporary data on gender differences in outcomes after transcatheter aortic valve implantation (TAVI), after stratification by age, remain limited. We studied age-stratified (60 to 70, 71 to 80, and 81 to 90 years) inhospital outcomes by gender after TAVI from the National Inpatient Sample database between 2012 and 2018. We analyzed National Inpatient Sample data using the International Classification of Diseases, Clinical Modification, Ninth Revision, and Tenth Revision claims codes. Between the years 2012 and 2018, a total of 188,325 weighted hospitalizations for TAVI were included in the analysis. (Source: The Americ...
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Salman Zahid, Muhammad Zia Khan, Waqas Ullah, Devesh Rai, Mian Tanveer Ud Din, Sakina Abbas, Aamer Ubaid, Muhammad Usman Khan, Samarthkumar Thakkar, Mohammad Abu Sheikha, Amr Salama, Bipul Baibhav, Mohan Rao, Sudarshan Balla, Mohamad Alkhouli, Jeremiah P. Source Type: research

Meta-Analysis of 5-Year Risk of All-Cause Death or Stroke After Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement
Transcatheter aortic valve implantation (TAVI) is an established alternative to surgical aortic valve replacement (SAVR) for patients with severe symptomatic aortic stenosis.1,2 Its indication has expanded from high-risk to include a low surgical risk younger population. Although the short-term results of TAVI and SAVR in patients with intermediate or high surgical risk are similar,1,2 outcomes beyond short-term periods remain unclear. Recently, the results of 5-year follow-up of the Surgical Replacement and Transcatheter Aortic Valve Implantation (SURTAVI) trial has been reported, which showed a similar rate of the compos...
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Yujiro Yokoyama, Toshiki Kuno, Tomo Ando, Tadahisa Sugiura, Azeem Latib Source Type: research

Optical Coherence Tomographic Features of Pancoronary Plaques in Patients With Acute Myocardial Infarction Caused by Layered Plaque Rupture Versus Layered Plaque Erosion
This study aimed to investigate pancoronary plaque features of layered plaque rupture (LPR) and layered plaque erosion (LPE) in patients with acute myocardial infarction. Among 388 patients with acute myocardial infarction who underwent preintervention optical coherence tomography imaging of three coronary arteries, 190 patients with layered culprit plaque (49.0%) were identified and further divided into 2 groups: LPR group and LPE group. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Yanwei Yin, Chao Fang, Senqing Jiang, Jifei Wang, Yidan Wang, Junchen Guo, Fangmeng Lei, Sibo Sun, Xueying Pei, Ruyi Jia, Caiying Tang, Shaotao Zhang, Lulu Li, Yini Wang, Huai Yu, Jiannan Dai, Bo Yu Source Type: research

Inflammatory Markers and Risk of Heart Failure With Reduced to Preserved Ejection Fraction
Chronic systemic inflammation is associated with an increased risk of heart failure (HF). We sought to determine the association between biomarkers of systemic inflammation interleukin (IL)-6, IL-2, tumor necrosis factor alpha (TNF- α), and C-reactive protein (CRP) with those of HF and its subtypes. We hypothesize that inflammatory biomarkers IL-6, IL-2, TNF-α, and CRP are associated with HF and its subtypes. We included participants from the Multi-Ethnic Study of Atherosclerosis (a prospective population-based cohort study [ 2000 to 2002]), without a history of HF, and with available baseline inflammatory biom...
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Zainab Albar, Marwah Albakri, Jamal Hajjari, Mohamad Karnib, Scott E. Janus, Sadeer G. Al-Kindi Source Type: research

Impact of Pulmonary Hypertension on Outcomes in Patients With Mitral Annular Calcium and Associated Mitral Valve Dysfunction
The prevalence of mitral annular calcium (MAC) is increasing in our aging population. However, data regarding prognostication in MAC-related mitral valve (MV) disease remain limited. This retrospective observational study aims to explore the prognostic impact of systolic pulmonary artery pressure (SPAP) in MAC-related MV dysfunction and define its determinants. We identified 4,384 patients (mean age 78 ± 11 years and 69% female) with MAC-related MV dysfunction (documented transmitral gradient ≥3 mm Hg) from a large institutional echocardiographic database between 2001 and 2019. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: S ébastien Deferm, Philippe B. Bertrand, Evin Yucel, Samuel Bernard, Mayooran Namasivayam, Yasufumi Nagata, Jacob P. Dal-Bianco, Danita Y. Sanborn, Michael H. Picard, Robert A. Levine, Judy Hung, Timothy W. Churchill Source Type: research

Safety of Bariatric Surgery in Obese Patients With Hypertrophic Cardiomyopathy
In this study, we examined national trends and early outcomes of bariatric surgery for obesity in patients with HC. Using the weighted discharge data from the National Inpatient Sample, we identified adult patients with HC who underwent elective bariatric surgery for obesity between 2011 and 2017. A total of 443 obese patients with HC were identified, and 42% (n  = 185) had obstructive HC. The annual number of patients increased from 18 in 2011 to 130 in 2017. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Daokun Sun, Hartzell V. Schaff, Travis J. McKenzie, Rick A. Nishimura, Jeffrey B. Geske, Joseph A. Dearani, Steve R. Ommen Source Type: research

Long-Term Risk of Heart Failure-Related Death and Heart Transplant After Congenital Heart Surgery in Childhood (from the Pediatric Cardiac Care Consortium)
We aimed to describe the longitudinal risk of advanced heart failure (HF) leading to death, heart transplantation, or ventricular assist device (VAD) placement after congenital heart surgery (CHS) and how it varies across the spectrum of congenital heart disease. We linked the records of patients who underwent first CHS in the Pediatric Cardiac Care Consortium between 1982 and 2003 with the United States National Death Index and Organ Procurement and Transplantation Network databases. Primary outcome was time from CHS discharge to HF-related death, heart transplant, or VAD placement, analyzed with proportional hazards mode...
Source: The American Journal of Cardiology - January 3, 2022 Category: Cardiology Authors: Lydia K. Wright, Rachel Zmora, Yijian Huang, Matthew E. Oster, Courtney McCracken, William T. Mahle, Lazaros Kochilas, Andreas Kalogeropoulos Source Type: research

Incidence, Risk Factors, and Prognosis of Cholesterol Crystal Embolism Because of Percutaneous Coronary Intervention
Cholesterol crystal embolism (CCE) is a rare but serious complication of percutaneous coronary intervention (PCI). However, its incidence, risk factors, and prognosis in the contemporary era are not well known. We included 23,184 patients who underwent PCI in our institution between January 2000 and December 2019 in this study. The diagnosis of CCE was made histologically or by the combination of cutaneous signs and specific blood test results. In patients with CCE, we evaluated the incidence, risk factors, and prognosis. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 2, 2022 Category: Cardiology Authors: Kotaro Takahashi, Ayumi Omuro, Masanobu Ohya, Shunsuke Kubo, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Kazushige Kadota Source Type: research

Incidence, Clinical Characteristics and Short-Term Prognosis in Patients With Cardiogenic Shock and Various Left Ventricular Ejection Fractions After Acute Myocardial Infarction
The 2016 European Society of Cardiology Guidelines introduced a new term, mid-range left ventricular ejection fraction (mrEF) heart failure, however, the clinical characteristics and short-term outcomes in cardiogenic shock patients with mrEF after acute myocardial infarction remain unclear. This retrospective study analyzed the baseline characteristics, management, and outcomes according to the left ventricular ejection fraction (LVEF), reduced LVEF (rEF) ≤40%, mrEF 41% to 49%, and preserved LVEF (pEF) ≥50% in patients with acute myocardial infarction complicated by cardiogenic shock. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 2, 2022 Category: Cardiology Authors: Yi Jiang, Awadji Fabrice Boris, Yuansong Zhu, Hongbo Gan, Xiankang Hu, Yuzhou Xue, Zhenxian Xiang, Bryan Richard Sasmita, Gang Liu, Suxin Luo, Bi Huang Source Type: research

Divergent Effects of COVID-19 Pandemic on Reported Adverse Events for Percutaneous Aortic Valve Prostheses and Non –Allograft Tissue Valves
Cardiologists have adapted their practices significantly to address COVID-19 concerns. We sought to determine how the COVID-19 pandemic impacted heart valve replacement procedures, specifically examining the weekly reported rates of adverse events attributed to percutaneous aortic valve prostheses and non –allograft tissue heart valves. Using data from the Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database, we compared weekly adverse event reports during the year immediately preceding the pandemic (March 2019 to March 2020) to those during the first year of the pandem...
Source: The American Journal of Cardiology - January 2, 2022 Category: Cardiology Authors: Elsa S. Zhou, Sujata K. Bhatia Source Type: research

Intermediate-Term Outcomes Following Transcatheter Aortic Valve Implantation in Patients With a History of Supplemental Home Oxygen Use
This study aimed to evaluate intermediate-term outcomes of TAVI in patients with and without home oxygen use. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 2, 2022 Category: Cardiology Authors: Kris Kumar, Craig C. Morris, Ashraf Samhan, Tessa Herman, Trisha Chau, Gurion Lantz, Scott M. Chadderdon, Howard K. Song, Firas E. Zahr, Harsh Golwala Source Type: research

Risk Stratification in Brugada Syndrome: Never Forget the Electrocardiogram
After reading the commentary by Dendramis and colleagues1 on our article “dST-Tiso Interval, a Novel Electrocardiographic Marker of Ventricular Arrhythmia Inducibility in Individuals With Ajmaline-Induced Brugada Type I Pattern,”2 we would like to better specify the message of our study. We agree and would like to emphasize that the decision on whether or not to reco mmend an implantable cardioverter-defibrillator in patients with Brugada syndrome (BrS) should not be based solely on the induction of ventricular arrhythmia (VA) at programed ventricular stimulation (PVS), but should be made carefully weighing man...
Source: The American Journal of Cardiology - January 2, 2022 Category: Cardiology Authors: Saverio Iacopino Source Type: research

Editorial Board
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 1, 2022 Category: Cardiology Source Type: research

Contents
(Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 1, 2022 Category: Cardiology Source Type: research

Meta-Analysis of One-Month Dual Antiplatelet Therapy Versus Standard Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention
The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is still debated. Current American and European guidelines recommend at least 6 months of DAPT after drug-eluting stent placement in stable coronary artery disease, and at least 12 months after acute coronary syndrome.1,2 Recent advances with newer stent generations have helped reduce the duration of DAPT. A recent meta-analysis assessed short-term DAPT (1 to 3 months) versus standard DAPT (12 to 24 months) and reported lower bleeding risks with similar ischemic events using the abbreviated DAPT duration. (Source: The Am...
Source: The American Journal of Cardiology - December 31, 2021 Category: Cardiology Authors: Mohamed M.G. Mohamed, Safia Shaikh, Mohammed Osman, Babikir Kheiri Source Type: research

C-Reactive Protein and Frailty in Heart Failure
Frailty commonly coexists with heart failure and although both have been associated with neurohormonal dysregulation, inflammation, catabolism, and skeletal muscle dysfunction, there are still no defined biomarkers to assess frailty, especially from the perspective of populations with cardiovascular diseases. This is a cross-sectional study with 106 outpatients with heart failure, aged ≥60 years, which aimed to assess frailty through a physical (frailty phenotype) and multidimensional (Tilburg Frailty Indicator) approach and to analyze its association with inflammatory and humoral biomarkers (high sensitivity C-rea...
Source: The American Journal of Cardiology - December 30, 2021 Category: Cardiology Authors: Édina Caroline Ternus Ribeiro, Tamirys Delazeri Sangali, Nadine Oliveira Clausell, Ingrid Schweigert Perry, Gabriela Corrêa Souza Source Type: research

Catheter Ablation for Atrial Fibrillation in Patients ≤30 Years of Age
Pulmonary vein (PV) automaticity is an established trigger for paroxysmal atrial fibrillation (PAF), making PV isolation (PVI) the cornerstone of catheter ablation. However, data on triggers for atrial fibrillation (AF) and catheter ablation strategy in very young patients aged (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 30, 2021 Category: Cardiology Authors: Kivanc Yalin, Baris Ikitimur, Tolga Aksu, Emin Evren Ozcan, Wern Yew Ding, Ali Ugur Soysal, Evgeny Lyan, Charlotte Eitel, Serkan Saygi, Oguzhan Ekrem Turan, Christian Hendrik Hegeer, Roland Richard Tilz, Dhiraj Gupta Source Type: research

Disparities in Statin Use During Outpatient Visits of Adults (Age 18 to 64 Years) With Coronary Heart Disease in the Medicaid Population in the United States (from the National Ambulatory Medical Care Survey Database 2006 to 2015)
Statins have strong recommendations for secondary prevention of future cardiovascular events in patients with ischemic heart disease (IHD).1 However, statins remain vastly underused in patients with cardiovascular disease and those at high risk of cardiovascular disease.2 The identified factors contributing to health care disparities in vulnerable population include having a low income, older age, being residents of rural area, and residing in southeastern United States.3 Multiple analyses from various databases have reported that disparities in optimal use of statins are more prevalent among racial/ethnic minorities. (Sou...
Source: The American Journal of Cardiology - December 30, 2021 Category: Cardiology Authors: Abdul Mannan Khan Minhas, Sardar Hassan Ijaz Source Type: research

Meta-Analysis of Randomized Controlled Trials Evaluating the Effect of Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists on Blood Pressure Levels in Patients With Type 2 Diabetes Mellitus
Hypertension and type 2 diabetes mellitus (T2DM) are common co-morbidities, with hypertension being twice as frequent in patients with T2DM as in those without.1,2 Blood pressure (BP) control is of great importance in subjects with T2DM, to minimize the risk for cardiovascular and chronic kidney disease.3 High on-treatment BP levels also correlate with the incidence of major adverse cardiovascular outcomes and all-cause death; thus, adequate BP control should be placed at the epicenter.4 (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 30, 2021 Category: Cardiology Authors: Dimitrios Patoulias, Theodoros Michailidis, Christodoulos Papadopoulos, Asterios Karagiannis, Michael Doumas Source Type: research