Atrial Fibrillation Amplifies Heart Failure Risk in Anthracycline Treated Cancer Patients: Stacking Risk Factors in the Vulnerable
Atrial fibrillation (AF) is the most common arrhythmia in the world, with an estimated 12 million individuals affected in the United States by 2030 (1). AF and heart failure (HF) often co-exist and together confer a higher risk of cardiovascular complications and mortality(1-2). AF also is implicated in worsening HF. Up to 50% of patients who present with new-onset HF have AF; conversely, among those patients with new-onset AF, close to one third have HF (2). AF may cause or contribute to HF due to uncontrolled rapid heart rates, lower overall cardiac output due to incomplete atrial filling, and increased left atrial press...
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Leonard Ilkhanoff, Brett Atwater, Ana Barac Tags: Editorial Source Type: research
Etiologies and Impact of Exclusion Rates for Transcatheter Mitral and Tricuspid Valve Structural Heart Clinical Trials at a High Volume Quaternary Care Hospital
There are various devices under clinical investigation for transcatheter mitral valve intervention (TMVI) and tricuspid valve intervention (TTVI), but exclusion rates remain high. We aim to investigate exclusion rates for transcatheter mitral valve repair (TMVr), transcatheter mitral valve replacement (TMVR), transcatheter tricuspid valve repair (TTVr) and transcatheter tricuspid valve replacement (TTVR). There were a total of 129 patients who were referred to St. Francis Hospital& Heart Center valve clinic and completed screening between January 2021 and July 2022. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Lu Chen, Lin Wang, George Petrossian, Newell Robinson, William Chung, Matthew Henry, Dennis Mihalatos, Ruqiyya Bano, Jonathan Weber, Jaffar Khan, David J. Cohen, Andrew Berke, Ziad Ali, Omar K. Khalique Source Type: research
Transcatheter Intervention for Inoperable Tricuspid Surgical Prosthesis Dysfunction: Minimally Invasive Approach to Mitigate Heart Failure
Surgical tricuspid valve replacement, a relatively rarely performed procedure, has long been the standard of care for patients suffering from a variety of valvular diseases, including congenital anomalies, degenerative conditions and disfunction secondary to the left-heart disease (1). However, over time, surgical prostheses may deteriorate, posing a unique challenge for patients who have already undergone surgery. This can lead to debilitating heart failure symptoms and increased mortality rates. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Piotr Nikodem Rudzi ński, Jan Henzel, Adam Witkowski, Maciej Dąbrowski, Zenon Huczek, Wojciech Wojakowski, Radosław Targoński, Dariusz Jagielak, Paweł Kralisz, Marcin Demkow Tags: Brief report Source Type: research
Distal Vs. Proximal Radial Arterial Access For Percutaneous Coronary Angiography and Intervention: Updated Meta-Analysis Of Randomized Controlled Trials
Transradial access (TRA) has been the preferred method of arterial access for cardiac catheterization for more than three decades. 1 Compared to transfemoral access, TRA is associated with lower mortality in high-risk patients, fewer complications at the vascular site, and less bleeding 2. Radial artery occlusion (RAO) is a common complication of TRA, with incidence reported up to 10%3. Although RAO was once considered clinically insignificant due to the dual arterial blood supply of the hand, recent evidence has recognized RAO as an impediment to reintervention in patients requiring coronary bypass surgery with arterial c...
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Syed Hamza Mufarrih, Sajjad Haider, Nada Qaisar Qureshi, Mohammad Saud Khan, Mohammed Kazimuddin, Muhammad Shoaib Akbar, Sameer Saleem, Syeda Aleena Mufarrih, Avnish Tripathi, Aniruddha Singh, Mohammad Abdul Waheed Source Type: research
Distal versus Proximal Radial Artery Access for Cardiac Catheterization: 1-year Outcomes
Cardiac catheterization through the radial artery (RA) has been associated with lower access site complications and better clinical outcomes compared with the femoral artery approach [1 –7]. Distal radial artery (DRA) access in the anatomic snuffbox has recently emerged as an alternative approach to conventional proximal radial artery (PRA) access for percutaneous coronary interventions (PCI), with promising results reported by several small studies [8–12]. The DRA access has b een associated with lower rates of RA occlusion and access site hematoma than the PRA access, and an overall improvement in procedure ergonomic...
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Karim Al-Azizi, Ghadi Moubarak, Chadi Dib, Sameh Sayfo, Molly Szerlip, Sibi Thomas, Sarah Hale, Johanna Van Zyl, Richard M. Settele, Osniel Ramos Gonzalez, Stephanie J. Ventura, J. Michael DiMaio, Michael J. Mack, Srinivasa Potluri Source Type: research
Asymptomatic Aortic Stenosis: From Risk Stratification to Treatment
Our understanding of the natural history of aortic stenosis has significantly increased over the last decade. There have been considerable advances in the diagnosis and risk stratification of patients with aortic stenosis, as well as in surgical and anesthetic techniques. In addition, transcatheter aortic valve replacement has established itself as a viable alternative to surgical management. Inevitably, these developments have raised questions regarding the merits of waiting for symptom onset in asymptomatic patients with severe aortic stenosis before offering treatment. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Marko Banovic, Bernard Iung, Svetozar Putnik, Thabo Mahendiran, Marc Vanderheyden, Emanuele Barbato, Jozef Bartunek Source Type: research
The Characteristics of Primary Retrograde Approach Selection for Native Coronary Chronic Occlusion with Short Occlusion Length from the Japanese CTO-PCI Expert Registry
Although the coronary chronic total occlusion (CTO) crossing algorithm has been published, the characteristics associated with the first strategy selection for short-length lesions (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 1, 2024 Category: Cardiology Authors: Yusuke Ochiumi, Etsuo Tsuchikane, Koichi Kishi, Hisayuki Okada, Yoshiaki Ito, Yuji Oikawa, Ryohei Yoshikawa, Atsunori Okamura, Hiroyuki Tanaka, Osamu Katoh Source Type: research
Low Muscle Mass by Preprocedural Computed Tomography Is Associated With Worse Short-Term Outcomes in Transcatheter Aortic Valve Replacement Recipients
Low muscle mass (LMM) is associated with worse outcomes in various clinical situations. Traditional frailty markers have been used for preoperative risk stratification in patients who underwent transcatheter aortic valve replacement (TAVR). However, preoperative imaging provides an opportunity to directly quantify skeletal muscle mass to identify patients at higher risk of procedural complications. We reviewed all TAVR recipients from January to December 2018 and included individuals with preprocedural chest computed tomography. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Ian Persits, Saeid Mirzai, Kunaal S. Sarnaik, Maximilian C. Volk, James Yun, Serge Harb, Rishi Puri, Samir Kapadia, Amar Krishnaswamy, Po-Hao Chen, Grant Reed, W. H. Wilson Tang Source Type: research
Association Between Atrial Fibrillation Symptoms and Clinical Outcomes: A Prospective Multicenter Registry Study
Atrial fibrillation (AF) is the most common type of arrhythmia. The global incidence of AF has been increasing with the increase in the global population of the elderly. 1 AF can manifest as various symptoms, such as palpitations, dyspnoea, chest pain, fatigue, dizziness, syncope, and disordered sleep; however, AF can also be asymptomatic. AF can lead to structural changes in the heart, particularly in the left atrium (LA), which initiates and sustains AF. This remodelling process is characterised by enlargement and fibrosis of the atrial tissue, as well as changes in the electrical properties of the atria. (Source: The Am...
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Sang Jun Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Eue-Keun Choi, Jun Kim, Jin-Bae Kim, Young Soo Lee, Hyung Wook Park, Boyoung Joung Source Type: research
Low Muscle Mass by Pre-Procedural Computed Tomography is Associated with Worse Short-Term Outcomes in Transcatheter Aortic Valve Replacement Recipients
Transcatheter aortic valve replacement (TAVR) has transformed how aortic stenosis (AS) is treated. While it is considered the standard of care in elderly patients and those with prohibitively high surgical risk, its use has expanded to include intermediate- and low-risk patients.1-4 However, determining pre-operative risk remains challenging as most tools commonly used are indirect or calculate measures of frailty and strength.5 These markers have limited accuracy and do not account for direct skeletal muscle measurements, which have implications beyond functional status. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Ian Persits, Saeid Mirzai, Kunaal S. Sarnaik, Maximilian C. Volk, James Yun, Serge Harb, Rishi Puri, Samir Kapadia, Amar Krishnaswamy, Po-Hao Chen, Grant Reed, W.H. Wilson Tang Source Type: research
Associations between visceral fat, abdominal muscle, and coronary artery calcification: A cross-sectional analysis of the Multi-Ethnic Study of Atherosclerosis
Obesity significantly contributes to an individual's cardiometabolic health and is a risk factor for the development of cardiovascular disease, including heart failure and coronary artery disease 1. Obesity is most commonly clinically defined using BMI, and while this measure is useful for assessing weight status, it cannot differentiate between fat and muscle 2,3. Quantity, quality, and distribution of fat, specifically visceral abdominal fat, is associated with increased incidence of CVD risk factors and increased risk for cardiovascular disease 1,4,5. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Amier Haidar, Preethi Srikanthan, Karol Watson, Matthew Allison, Richard Kronmal, Tamara Horwich Source Type: research
Safety and Efficacy of Enoxaparin During Low-Risk Elective Percutaneous Coronary Intervention
Intravenous unfractionated heparin (UFH) is the most frequently used anticoagulant for percutaneous coronary intervention (PCI). Intravenous enoxaparin, a low-molecular weight heparin, has superior pharmacokinetic and pharmacodynamic properties compared with UFH. Multiple trials have shown enoxaparin to be safe and effective in PCI. However, there has not been a contemporary study evaluating its safety and efficacy. To assess its efficacy and safety, intravenous enoxaparin during PCI via radial artery access was evaluated in PCI patients from Jan 2015 to Dec 2019. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Hani Alturkmani, Barry Uretsky, Swetal Patel, Mu'nes Albadaineh, Omar Alqaisi, Malek Alaiwah, Michael Cross, Danish Abbasi, William Rollefson Source Type: research
Cardiovascular Outcomes With Empagliflozin and Dapagliflozin in Patients Without Diabetes
While the cardiovascular (CV) benefits with sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with diabetes mellitus (DM) are well known, their effects in patients without DM continue to be explored. We provide a meta-analysis of the available evidence. Online databases were searched for randomized controlled trials (RCTs) comparing SGLT2i to placebo/control in patients without DM. The endpoints of interest were composite CV death/hospitalization for heart failure (HF) with individual components, all cause death, major adverse CV events (MACE) and serious adverse events. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Sahib Singh, Aakash Garg, Udaya S Tantry, Kevin Bliden, Paul A Gurbel, Martha Gulati Source Type: research
Changes in Global Longitudinal Strain as a Predictor of Cardiotoxicity after Exposure to Carfilzomib
Multiple myeloma (MM) is associated with higher rates of adverse cardiac events1. Carfilzomib (CFZ) is a proteosome inhibitor approved for the treatment of relapsed and refractory MM and has known cardiotoxic effects. Global longitudinal strain (GLS) is an echocardiographic method often employed to identify subclinical left ventricular dysfunction that precedes declines in left ventricular ejection fraction (LVEF), commonly seen after treatment with other cardiotoxic agents, such as anthracyclines2. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Ranbir Singh, Dylan Sperling, Anthony Delicce, Sophia Golec, Supreet Singh, Nicole Zatorski, Solomon Bienstock, Sumeet Singh Mitter, Stamatios Lerakis, Gagan D. Sahni Tags: Brief report Source Type: research
Comprehensive Angiography-derived Functional Assessment of Epicardial and Microvascular Coronary Disease. Correlation With Non-invasive Myocardial Stress Imaging
Coronary angiography (CA) is poorly correlated with non-invasive myocardial stress imaging (NSI) and myocardial ischemia is often observed in patients with unobstructed coronary arteries. Moreover, the diagnostic performance of combined epicardial and microcirculatory angiography-derived physiological assessment and its correlation with NSI remains unknown. Nine-hundred-seventeen coronary vessels in 319 patients who underwent both CA and NSI were included in this multicenter observational retrospective analysis. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - February 29, 2024 Category: Cardiology Authors: Francesco Della Mora, Leonardo Portolan, Dimitrios Terentes-Printzios, Andrea Vicer è, Stefano Andreaggi, Marco Biasin, Gabriele Pesarini, Domenico Tavella, Caterina Maffeis, Elvin Tafciu, Giovanni Benfari, Dimitrios Oikonomou, Konstantia-Paraskevi Gkini Source Type: research
