Transient receptor potential vanilloid 4 channel inhibition attenuates lung ischemia-reperfusion injury in a porcine lung transplant model

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel important in many physiological and pathophysiological processes, including pulmonary disease. Using a murine model, we previously demonstrated that TRPV4 mediates lung ischemia-reperfusion injury, the major cause of primary graft dysfunction after transplant. The current study tests the hypothesis that treatment with a TRPV4 inhibitor will attenuate lung ischemia-reperfusion injury in a clinically relevant porcine lung transplant model.

Source: The Journal of Thoracic and Cardiovascular Surgery - April 27, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Raymond J. Strobel, Huy Q. Ta, Andrew M. Young, Alex M. Wisniewski, Anthony V. Norman, Evan P. Rotar, Mark H. Stoler, Irving L. Kron, Swapnil K. Sonkusare, Mark E. Roeser, Victor E. Laubach Tags: Thoracic Source Type: research