Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device
Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT following LVAD has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably impacts acute hemodynamics in patients with an LVAD and CRT device. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 21, 2018 Category: Cardiology Authors: Joanna M. Joly, Deepak Acharya, Harish Doppalapudi, G. Neal Kay, Chee Paul Lin, William R. Maddox, H. Thomas McElderry, Salpy V. Pamboukian, Vance J. Plumb, Indranee N. Rajapreyar, Jos é A. Tallaj, Takumi Yamada, Vineet Kumar Tags: Research Letter Source Type: research

Right Ventricular Free Wall Strain is Associated with Long Term Renal Function in Heart Failure with Preserved Ejection Fraction.
Renal impairment in heart failure with preserved ejection fraction (HFpEF) is associated with worse outcomes and higher mortality [1]. The impact of abnormal right ventricular mechanics on mortality and heart failure related hospitalizations has been described [2]. However, there are limited data looking at the association between right ventricular cardiac mechanics and long-term renal function in HFpEF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 21, 2018 Category: Cardiology Authors: Kevin Bryan Lo, Pradhum Ram, Napatt Kanjanahattakij, Shuchita Gupta, Gregg S. Pressman, Janani Rangaswami Source Type: research

The Impella Micro-Axial Flow Catheter is Safe and Effective for Treatment of Myocarditis Complicated by Cardiogenic Shock: An Analysis from the Global cVAD Registry
Myocarditis complicated by cardiogenic shock remains a complex clinical problem. Myocarditis refers to heart specific infectious or non-infectious inflammatory conditions with clinical manifestations ranging from mild, non-specific symptoms to cardiogenic shock [1]. Therapeutic options for myocarditis are limited. Aggressive immunosuppressive regimens have not been shown to impact mortality or left ventricular ejection fraction [2, 3]. Trans-valvular pumps (Impella, Abiomed, Danvers, MA) provide hemodynamic support [4, 5] by decreasing cardiac workload while increasing systemic mean arterial pressure (MAP) [6-8]. (Source: ...
Source: Journal of Cardiac Failure - September 20, 2018 Category: Cardiology Authors: Shiva K. Annamalai, Michele L. Esposito, Lena Jorde, Theodore Schreiber, Shelley Hall, William W. O'Neill, Navin K. Kapur Source Type: research

Pupillary light reflex as a new prognostic marker in patients with heart failure
Heart failure (HF) is one of the leading causes of death globally1. Neuroendocrine dysregulation is among the most important pathophysiological factors involved in the high mortality rate associated with HF2. Neuroendocrine dysregulation is observed mainly as an imbalance of autonomic control3, and is characterized by markedly elevated sympathetic activation4 and parasympathetic withdrawal5. Autonomic function is generally evaluated by heart rate variability obtained from Holter electrocardiography6, and its clinical implications have been demonstrated in patients with HF7, 8. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 20, 2018 Category: Cardiology Authors: Kohei Nozaki, Kentaro Kamiya, Yuya Matsue, Nobuaki Hamazaki, Ryota Matsuzawa, Shinya Tanaka, Emi Maekawa, Takuya Kishi, Atsuhiko Matsunaga, Takashi Masuda, Toru Izumi, Junya Ako Tags: Clinical Investigation Source Type: research

Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension – results from BEET-PAH an exploratory randomized, double-blind, placebo-controlled crossover study
Pulmonary arterial hypertension (PAH) is a rare, progressive, symptomatic, and ultimately fatal disease associated with a progressive elevation of the pulmonary arterial pressure and the pulmonary vascular resistance resulting in right heart failure (1). Endothelial dysfunction, a pathological feature of PAH, is attributed to the imbalance between endogenous pulmonary vasodilators and vasoconstrictors, in particular nitric oxide (NO), prostacyclin and endothelin-1 (2, 3). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 20, 2018 Category: Cardiology Authors: Dan Henrohn, Kristoffer Bj örkstrand, Jon O. Lundberg, Sven-Olof Granstam, Tomasz Baron, Inga J. Ingimarsdóttir, Hans Hedenström, Andrei Malinovschi, Mona-Lisa Wernroth, Martin Jansson, Mikael Hedeland, Gerhard Wikström Source Type: research

Relations of vitamin D status with B-type natriuretic peptide levels and the risk of cardiac events in Japanese subjects with heart failure
Several prior studies have shown that Vitamin D insufficiency and deficiency are very common in patients with heart failure (HF)1, 2 and that very low levels are associated with increased mortality.3-5 However, none of the prior studies specifically targeted a Japanese population where the prevalence of HF is rapidly increasing because of a steady increase in the aging society.6 We aimed to clarify the frequency of vitamin D deficiency in Japanese patients with HF, and to determine whether 25-hydroxyvitamin D [25(OH)D] is an independent predictor for adverse outcome. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 19, 2018 Category: Cardiology Authors: Kyoko Otani, Yukie Higa, Kanako Tanaka, Hiroko Adachi, Akemi Nakazono, Yosuke Nabeshima, Masahisa Honda, Yutaka Otsuji, Masaaki Takeuchi Tags: Letters to the Editor Source Type: research

Will the Early Use of Biomarkers Prevent the Development of Heart Failure?
There are several factors known to increase the risk of developing heart failure, with both a normal (HFpEF) and decreased (HFrEF) left ventricular ejection fraction. Prominent amongst these risks include increasing age, atherosclerotic heart disease (with/without myocardial infarction), systemic hypertension, and diabetes. These conditions are considered Stage A in the spectrum of heart failure (1) and surveillance is recommended but the specific methods have not been well defined. When there is evidence of a cardiac structural abnormality, such left ventricular hypertrophy or a reduction in the LVEF (Stage B), then speci...
Source: Journal of Cardiac Failure - September 14, 2018 Category: Cardiology Authors: Eugene E. Wolfel Source Type: research

Estimation of Incident Heart Failure Risk in Us Hispanics/Latinos Using a Validated Echocardiographic Risk-Stratification Index: HCHS/SOL Echo Study of Latinos
The lifetime risk of developing incident heart failure (HF) in the US is 20% for individuals older than 40 years.1 Few HF scores rely solely on echocardiographic parameters of cardiac structure and function to determine the risk of incident HF. Among these, the Heart and Soul Study (HSS) developed a validated echocardiographic risk-stratification index (ERSI) in participants with stable coronary artery disease to predict the 4-year probability of incident HF among asymptomatic individuals, independent of and superior to clinical risk factors. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 14, 2018 Category: Cardiology Authors: M. Octavia Rangel, Robert Kaplan, Martha Daviglus, Neil Schneiderman, Barry E. Hurwitz, Jianwen Cai, Franklyn Gonzalez, Dalane Kitzman, Mayank Kansal, Carlos J. Rodriguez Source Type: research

Lower extremity function is independently associated with hospitalization burden in heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) has reached epidemic proportions in the developed world, and now represents approximately half of heart failure (HF) cases. Patients with HFpEF are typically older adults who have multiple additional comorbid illnesses. As the population ages and associated comorbidities become more common, the prevalence of HFpEF is expected to rise sharply in the years ahead1. Unfortunately, outcomes remain poor despite multiple large clinical trials of well-reasoned cardiovascular therapies, possibly because many deaths and hospitalizations in patients with HFpEF are non-cardiovascu...
Source: Journal of Cardiac Failure - September 13, 2018 Category: Cardiology Authors: Whitney E. Hornsby, Mohamed-Ali Sareini, Jessica R. Golbus, Cristen J. Willer, Jennifer L. McNamara, Matthew C. Konerman, Scott L. Hummel Tags: Clinical Investigation Source Type: research

Very early diuretic response after admission for acute heart failure
Intravenous loop diuretics are the cornerstone of treatment of hospitalized heart failure patients (1-3). A poorer response to diuretic treatment was consistently related to worse outcomes. Poor renal function, low systolic blood pressure, ischemic etiology of heart failure, and diabetes are associated with poor diuretic response (DR) during 24-96 hours after hospital admission (4-6). Therefore, strategies to improve DR in hospitalized heart failure patients are currently being considered. However, some important information for these strategies are currently missing. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 13, 2018 Category: Cardiology Authors: Shunsuke Kuroda, Kevin Damman, Jozine M. ter Maaten, Adriaan A. Voors, Takahiro Okumura, Keisuke Kida, Shogo Oishi, Eiichi Akiyama, Satoshi Suzuki, Masayoshi Yamamoto, Takeshi Kitai, Kazuki Yoshida, Akihiko Matsumura, Yuya Matsue Tags: Clinical Investigation Source Type: research

Rare Diseases Inform Myocardial Phenotypes for Precision Medicine
Friedreich's Ataxia (FA) is an autosomal recessive ‘triplet repeat’ disorder characterized by cerebellar degeneration, long tract and a generalized myopathy.1 While neurological symptoms typically antedate any clinical cardiac involvement, heart failure remains the dominant cause of death in FA. The genetic basis of the disorder is dramatic expa nsion of a GAA repeat sequence in the first intron of the FRDA gene which encodes an iron-binding mitochondrial protein whose function remains incompletely understood. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 13, 2018 Category: Cardiology Authors: Calum A. MacRae Tags: Brief Report Source Type: research

A Critical Appraisal of Short-term Endpoints in Acute Heart Failure Clinical Trials
The prevalence of heart failure continues to grow and this is accompanied by an increase in hospitalization for acute heart failure. Hospitalization for heart failure results in a trajectory shift of the syndrome and is associated with worsening outcomes, increased mortality risk, and high costs. Numerous clinical trials over the past two decades have had limited success with not a single agent shown to improve mortality risk. The lack of success is multifactorial and in part related to inadequate targets and endpoints selected for intervention, underscoring the need to better understand and define the pathophysiology of a...
Source: Journal of Cardiac Failure - September 11, 2018 Category: Cardiology Authors: Carine E. Hamo, Christopher O'Connor, Marco Metra, James E. Udelson, Mihai Gheorghiade, Javed Butler Tags: Review Article Source Type: research

A multi-site randomized controlled trial of a patient centered ventricular assist device decision aid (vadda)
Studies indicate that decision making and informed consent among patients considering Left Ventricular Assist Device (LVAD) support for advanced heart failure could be improved. In the VADDA (ventricular assist device decision aid) trial, we tested a patient-centered decision aid (DA) to enhance the quality of decision making about LVAD therapy. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 6, 2018 Category: Cardiology Authors: Kristin M. Kostick, Courtenay R. Bruce, Charles G. Minard, Robert J. Volk, Andrew Civitello, Selim R. Krim, Douglas Horstmanshof, Vinay Thohan, Matthias Loebe, Hanna Mazen, Brian A. Bruckner, J.S. Blumenthal-Barby, Jerry D. Estep Tags: Clinical Trials Source Type: research

Effects of endurance training on detrimental structural, cellular, and functional alterations in skeletal muscles of heart failure with preserved ejection fraction
This study used an animal model of HFpEF to better understand whether skeletal muscle abnormalities were: 1) fiber-type specific; and 2) reversible by various exercise training regimes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 6, 2018 Category: Cardiology Authors: T. Scott Bowen, Christian Herz, Natale P.L. Rolim, Anne-Marie Ormbostad Berre, Martin Halle, Angela Kricke, Axel Linke, Gustavo Justo da Silva, Ulrik Wisloff, Volker Adams Tags: Basic Science and Experimental Studies Source Type: research

Right Ventricular Hypertrophy and Dilatation in Patients with HIV in the Absence of Clinical or Echocardiographic Pulmonary Hypertension
Cardiovascular involvement is common in patients infected with Human Immunodeficiency Virus (HIV), which may manifest itself as nonischemic dilated cardiomyopathy, ischemic heart disease or pulmonary hypertension (PH), according to the tissues involved.1,2 Involvement of right-sided heart chambers is observed in up to 7%-69% of patients; depending on the definition of “involvement”, the severity of HIV infection, the use of antiretroviral treatment (ART) and the modality used for diagnosis.3,4 Right ventricular (RV) involvement by HIV may manifest itself as RV enlargement, hypertrophy of the right ventricular f...
Source: Journal of Cardiac Failure - September 6, 2018 Category: Cardiology Authors: Rengin Çetin Güvenç, Nurgül Ceran, Tolga Sinan Güvenç, Hacer Ceren Tokgöz, Yalçın Velibey Tags: Clinical Investigation Source Type: research

Effect of Mineralocorticoid Receptor Antagonists in Individuals with Heart Failure with Preserved Ejection Fraction: A Systematic Review
Heart failure with preserved ejection fraction (HFpEF) represents about 50% of the patients with heart failure and has been getting growing attention in research and clinical practice. Exercise capacity is an important prognostic variable in HFpEF and has been considered as a major outcome in clinical trials. However, clinical trials about the effect of mineralocorticoid receptor antagonists (MRAs) in patients with HFpEF have shown conflicting results.1 –5 The aim of this systematic review was to investigate the effects of MRAs on exercise capacity, VE/VCO2 slope, quality of life, E/e’ ratio and left ventricula...
Source: Journal of Cardiac Failure - September 5, 2018 Category: Cardiology Authors: B ÁRBARA PEREIRA FERNANDES, LINO SERGIO ROCHA CONCEIÇÃO, PAULO RICARDO SAQUETE MARTINS-FILHO, DOUGLAS RAFANELLE MOURA DE SANTANA MOTTA, VITOR OLIVEIRA CARVALHO Tags: Brief Report Source Type: research

One-Year Cardiovascular Outcomes in Patients with Peripartum Cardiomyopathy
We examined the cardiovascular outcomes of one-year survivors of PPCM in a large, commercially-insured population.Methods and Results A retrospective cohort study was conducted using administrative claims from patients ages 15 to 54 years insured by a national commercial payer during 2005 to 2012. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 4, 2018 Category: Cardiology Authors: Elias J. Dayoub, Hema Datwani, Jennifer Lewey, Peter W. Groeneveld Source Type: research

High-Sensitivity Troponin T and Incident Heart Failure in Older Men: British Regional Heart Study
The lifetime risk of developing heart failure (HF) of a person aged>40years in the general population is estimated to be 20%, and although therapies for HF are improving, once diagnosed, 14% of patients die in the first 6 months.1,2 The etiology of HF varies from country to country, although the majority of cases are attributed to hypertension and coronary artery disease.3 As such, it is well understood that onset of HF is a common occurrence after clinically diagnosed myocardial infarction.4 However, it is possible that recurrent subclinical episodes of cardiac ischemia and cardiomyocyte necrosis lead to HF. (Source: J...
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Paul Welsh, Olia Papacosta, Sheena Ramsay, Peter Whincup, John McMurray, Goya Wannamethee, Naveed Sattar Tags: Clinical Investigation Source Type: research

Decoupling Between Diastolic Pulmonary Arterial Pressure and Pulmonary Arterial Wedge Pressure at Incremental Left Ventricular Assist Device (LVAD) Speeds Is Associated With Worse Prognosis After LVAD Implantation
Pulmonary hypertension (PH) is one of the critical comorbidities in advanced heart failure (HF).1,2 Indices of PH such as mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), and transpulmonary arterial pressure gradient improve after left ventricular assist device (LVAD) implantation, mainly owing to left ventricular unloading.3,4 Several investigators demonstrated in small cohorts that patients whose elevated PVRs were normalized after LVAD implantation had post –heart transplantation survival rates similar to those without PH. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Teruhiko Imamura, Gene Kim, Jayant Raikhelkar, Nitasha Sarswat, Sara Kalantari, Bryan Smith, Daniel Rodgers, Ben Chung, Ann Nguyen, Takeyoshi Ota, Tae Song, Colleen Juricek, Valluvan Jeevanandam, Daniel Burkhoff, Gabriel Sayer, Nir Uriel Tags: Clinical Investigation Source Type: research

Validation and Recalibration of Seattle Heart Failure Model in Japanese Acute Heart Failure Patients
Cardiovascular disease is the leading cause of death throughout the world. In Asian countries, it is estimated that 4.2 million individuals have heart failure (HF).1,2 Moreover, the number of HF patients is predicted to increase worldwide. In Japan, it has been estimated that the number of HF patients will increase from 1 million in 2005 to 1.3 million by 2030.3 In addition, in most non-Western countries, heart transplantation (HT) is a limited option because of the shortage of donors.4 For instance, only 30 −40 cases are performed annually in Japan, largely because of religious reasons and delays in the legal system...
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Yasuyuki Shiraishi, Shun Kohsaka, Toshiyuki Nagai, Ayumi Goda, Atsushi Mizuno, Yuji Nagatomo, Yasumori Sujino, Ryoma Fukuoka, Mitsuaki Sawano, Takashi Kohno, Keiichi Fukuda, Toshihisa Anzai, Ramin Shadman, Todd Dardas, Wayne C Levy, Tsutomu Yoshikawa Tags: Clinical Investigation Source Type: research

Parvovirus B19 in endomyocardial biopsy of patients with idiopathic dilated cardiomyopathy: foe or bystander?
Background: Parvovirus B19 (PVB19) has emerged as one of the viruses possibly inducing chronic myocarditis and subsequent IDCM.Aim: to investigate the presence and the long-term consequences of PVB19-DNA within myocardial biopsies in patients with IDCM and to compare the findings with those of donor hearts (control group).Methods and results: 40 hospitalized IDCM patients (age 47 ±12y) with LVEF 27 ±12% were included. The presence of PVB19-DNA in myocardial biopsies, and of IgG and IgM antibodies in patient sera was analysed. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: C. Hjalmarsson, J-A. Liljeqvist, M. Lindh, K. Karason, E. Bollano, A. Oldfors, B. Andersson Source Type: research

Alveolar air and O2 uptake during exercise in patients with heart failure
This study aimed to phenotype how change s in alveolar ventilation (V̇A), volume (VA), and related parameters couple with exercise V̇O2 in HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Erik H. Van Iterson, Joshua R. Smith, Thomas P. Olson Source Type: research

High sensitivity troponin T and incident heart failure in older men: British Regional Heart Study
The lifetime risk of developing heart failure (HF) of a person aged over 40 years in the general population is estimated at 20% and, although therapies for HF are improving, once diagnosed 14% of patients die in the first six months. [1,2] The etiology of HF varies from country to country, although the majority of cases are attributed to hypertension and coronary artery disease. [3] As such, it is well understood that onset of HF is a common occurrence after clinically diagnosed myocardial infarction. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Paul Welsh, Olia Papacosta, Sheena Ramsay, Peter Whincup, John McMurray, Goya Wannamethee, Naveed Sattar Source Type: research

Decoupling between Diastolic Pulmonary Artery Pressure and Pulmonary Artery Wedge Pressure at Incremental LVAD speeds is Associated with Worse Prognosis following LVAD Implantation
Pulmonary hypertension (PH) is one of the critical comorbidities in advanced heart failure (HF).1,2 Indices of PH such as mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), and trans-pulmonary artery pressure gradient improve following left ventricular assist device (LVAD) implantation mainly due to left ventricular unloading.3,4 Several investigators demonstrated in small cohorts that patients whose elevated PVRs were normalized following LVAD implantation had comparable post-heart transplant survival rates to those without PH. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2018 Category: Cardiology Authors: Teruhiko Imamura, Gene Kim, Jayant Raikhelkar, Nitasha Sarswat, Sara Kalantari, Bryan Smith, Daniel Rodgers, Ben Chung, Ann Nguyen, Takeyoshi Ota, Tae Song, Colleen Juricek, Valluvan Jeevanandam, Daniel Burkhoff, Gabriel Sayer, Nir Uriel Tags: Clinical Investigation Source Type: research

Sex-Specific Trends in Incidence and Mortality for Urban and Rural Ambulatory Heart Failure Patients in Eastern Ontario from 1994-2013
Heart failure (HF) remains a significant cause of morbidity and mortality with an estimated lifetime risk of 1 in 5.1,2 Despite the current era of goal directed medical therapy, HF continues to be a leading cause of admission to hospital, it is associated with a poor prognosis and contributes to 35% of total female cardiovascular mortality.3 Urban-rural differences in morbidity, mortality, access to care, medication utilization and cost of care have been reported in many cohorts of cardiovascular disease, including stroke,4 acute myocardial infarction,5 stable ischemic heart disease6 and acute heart failure;7,8 only one of...
Source: Journal of Cardiac Failure - August 9, 2018 Category: Cardiology Authors: Louise Y. Sun, Jack V. Tu, Heather Sherrard, Norvinda Rodger, Thais Coutinho, Michele Turek, Elizabeth Chan, Heather Tulloch, Lisa McDonnell, Lisa M. Mielniczuk Source Type: research

Assessment of congestion in acute heart failure: when simplicity does not go along with accuracy
Congestion is by far the main cause of hospitalization for the patients with heart failure. Its persistence at the time of discharge is among the most powerful prognostic factors.1 –3 Regrettably, no new treatment has been shown to be effective in patients hospitalized for acute heart failure. No changes in the guidelines for acute heart failure have occurred and patient outcomes have remained constant through the years.4–7 In the absence of new therapies to treat congesti on, the focus has seemingly shifted to the development of measures designed to better assess congestion and its relief before discharge. (So...
Source: Journal of Cardiac Failure - August 9, 2018 Category: Cardiology Authors: Marco Metra, Nicol ò Dasseni, Carlo Lombardi Tags: Brief Report Source Type: research

Calculated Estimates of Plasma Volume in Patients With Chronic Heart Failure —Comparison With Measured Volumes
Volume overload with clinical congestion remains a prominent issue in the management of patients with chronic heart failure (HF) and has significant prognostic implications.1,2 Although direct quantification of plasma volume (PV) has been shown to have clinical utility to reveal the often unrecognized marked heterogeneity and relative severities in volume overload of patients with chronic HF,3 –6 this methodology has not always been readily available to clinicians. Therefore, multiple surrogates have been advanced and used to provide an assessment of intravascular volume status. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 8, 2018 Category: Cardiology Authors: Marat Fudim, Wayne L Miller Tags: Clinical Investigation Source Type: research

Calculated Estimates of Plasma Volume in Patients with Chronic Heart Failure – Comparison to Measured Volumes
Volume overload with clinical congestion remains a prominent issue in the management of patients with chronic heart failure (HF) and has significant prognostic implications.1,2 While direct quantification of plasma volume (PV) has been shown to have clinical utility to reveal the often unrecognized marked heterogeneity and relative severities in volume overload of patients with chronic HF,3-6 this methodology has not always been readily available to clinicians. Therefore, multiple surrogates have been advanced and utilized to provide an assessment of intravascular volume status. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 8, 2018 Category: Cardiology Authors: Marat Fudim, Wayne L. Miller Source Type: research

Substantial Reduction in Driveline Infection Rates with the Modification of Driveline Dressing Protocol
As the number of heart transplants performed per year has plateaued, the use of continuous-flow left ventricular assist devices (CF-LVADs) as both bridge to transplant and destination therapy has increased (1). The increased utilization of CF-LVADs has led to a growing number of patients living longer with durable mechanical circulatory support, and therefore exposed to infectious risks. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 8, 2018 Category: Cardiology Authors: Matthew M. Lander, Nicole Kunz, Elizabeth Dunn, Andrew D. Althouse, Kathy Lockard, Michael A. Shullo, Robert L. Kormos, Jeffrey J. Teuteberg Source Type: research

A Prospective Pilot Study of Pocket-Carried Ultrasound Pre- and Postdischarge Inferior Vena Cava Assessment for Prediction of Heart Failure Rehospitalization
Rehospitalization for heart failure (HF) is common. Subclinical congestion may be present at discharge despite improvement in HF symptoms and physical examination findings.1 The size and collapsibility of the inferior vena cava (IVC) correlate with right atrial pressure and act as noninvasive surrogates for volume status.2 Larger IVC size and lower collapsibility at discharge, assessed via bedside ultrasound, are predictive of rehospitalization.3 Patients hospitalized for HF are at higher risk of subsequent HF hospitalization compared with outpatients with chronic HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 3, 2018 Category: Cardiology Authors: Ehimare Akhabue, Jacob B. Pierce, Laura J. Davidson, Stuart B. Prenner, Raja K. Mutharasan, Jyothy J. Puthumana, Sanjiv J. Shah, Allen S. Anderson, James D. Thomas Tags: Brief Report Source Type: research

A Prospective Pilot Study of Pocket-carried Ultrasound Pre- and Post-Discharge Inferior Vena Cava Assessment for Prediction of Heart Failure Re-hospitalization
Re-hospitalization for heart failure (HF) is common. Subclinical congestion may be present at discharge despite improvement in HF symptoms and physical exam findings.1 The size and collapsibility of the inferior vena cava (IVC) correlate to right atrial pressure and act as non-invasive surrogates for volume status.2 Larger IVC size and lower collapsibility at discharge assessed via bedside ultrasound are predictive of re-hospitalization.3 Patients hospitalized for HF are at higher risk of subsequent HF hospitalization compared to outpatients with chronic HF who are not. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 3, 2018 Category: Cardiology Authors: Ehimare I. Akhabue, Jacob B. Pierce, Laura J. Davidson, Stuart B. Prenner, Raja K. Mutharasan, Jyothy J. Puthumana, Sanjiv J. Shah, Allen S. Anderson, James D. Thomas Tags: Brief Report Source Type: research

The Hemodynamic Profile of GI Bleeding in Continuous-Flow LVADs: Is it All About the Right Ventricle?
The last decade has seen LVADs emerge as an effective and durable means to support select patients with advanced heart failure. Despite improvements in heart failure morbidity and mortality with mechanical support, device-related complications remain a challenge. While rates of pump thrombosis, driveline infection and stroke have declined with improvements in pump design and patient care strategies, the risk of gastrointestinal (GI) bleeding has remained constant.1 GI bleeding remains the leading cause of hospital readmission following device implant, occurring in 30% of patients with continuous-flow LVADs and negatively i...
Source: Journal of Cardiac Failure - August 2, 2018 Category: Cardiology Authors: Christopher T. Sparrow, Joel D. Schilling Source Type: research

The Heart-Brain Continuum: A New Way of Looking at Heart Failure Therapy
The heart and the brain are inextricably linked by bi-directional neural pathways that modulate neuro-cardiac reflexes, a common dependence and sensitivity to the vicissitudes of vascular flow and pressures and a shared susceptibility to the pathologic effects of aging and atherosclerosis. It would therefore seem axiomatic that heart failure (HF), a disease that disproportionally affects the aged, alters the homeostasis of the vasculature and activates neural network signaling would have significant effects on the patho-biology of the brain. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 2, 2018 Category: Cardiology Authors: Arthur Feldman Tags: Brief Report Source Type: research

Epigenomic Control of Cardiac Fibrosis by Bet Bromodomain Proteins in Dilated Cardiomyopathy
Pathologic gene expression is a hallmark of DCM. Mice carrying a human DCM mutation in phospholamban (PLNR9C) develop fibrosis, DCM, HF and premature death. RNAseq showed fibrotic gene expression to be a key early driver of DCM in PLNR9C mice. Recently, bromodomain and extraterminal (BET) epigenetic reader proteins have been identified as key regulators of pathologic gene expression in the heart. Using a chemical genetic strategy, we studied the role of BET proteins on the temporal regulation of gene expression in DCM. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Michael A. Burke, Hiroko Wakimoto, Zhe Jiao, Joshua M. Gorham, Steven R. DePalma, David A. Conner, Jun Qi, Jonathan G. Seidman, James E. Bradner, Jonathan D. Brown, Saptarsi M. Haldar, Christine E. Seidman Tags: 001 Source Type: research

Elevated Sera sST2 Predicts Heart Failure in Men Under the Age of 50 with Clinically Suspected Myocarditis
In this study we investigated whether sera sST2 levels were associated with low left ventricular ejection fraction (LVEF) or New York Heart Association (NYHA) class in myocarditis patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Katelyn A. Bruno, Michael J. Coronado, Lori Blauwet, Erika Douglass, Eric Abston, Adriana Bucek, J. Augusto Frisancho, Merci S. Greenaway, Anneliese R. Hill, Leslie T. Cooper, DeLisa Fairweather Tags: 002 Source Type: research

A Cardiac-Specific Regulatory Genetic Variant for Protein Kinase C α is Significantly Associated with Mortality in Patients with Heart Failure
Protein kinase C α (PRKCA) is a fundamental regulator of beta-adrenergic signaling and cardiac contractility. Previous studies suggested that increased cardiac expression of PRKCA is associated with adverse cardiac outcomes. Cardiac expression of PRKCA is partly genetically regulated, with the recently identified r s9909004 (T→C) as the most likely regulatory variant in failing human heart tissue, but the clinical impact of rs9909004 genotype remains unknown. Therefore the objectives of this study were to determine whether PRKCA rs9909004 genotype is associated with mortality in patients with heart failure a nd ...
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Jasmine A. Luzum, Christopher Ting, Edward Peterson, Hongsheng Gui, Liang Li, Wolfgang Sadee, Danxin Wang, David E. Lanfear Tags: 003 Source Type: research

Increased Frequency of CD4+CD57+ Senescent T Cells in Patients with Acute Heart Failure: Exploring New Pathogenic Mechanisms with Clinical Relevance
We examined the immunological characteristics and clinical implications of various T-cell subsets in acute HF patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Jong-Chan Youn, Min Kyung Jung, In-Cheol Kim, Myung Soo Park, Sun-Ki Lee, Suk-Won Choi, Seongwoo Han, Kyu-Hyung Ryu, Seok-Min Kang, Eui-Cheol Shin Tags: 004 Source Type: research

The β-Adrenergic Agonist Albuterol Improves Pulmonary Vascular Reserve in Heart Failure with Preserved Ejection Fraction: A Randomized Controlled Trial
Heart failure with preserved ejection fraction (HFpEF) is associated with pulmonary vascular dysfunction, particularly during exercise. Pulmonary vasodilators may favorably reduce pulmonary artery (PA) tone in HFpEF, but this could theoretically worsen left atrial hypertension and pulmonary congestion. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Yogesh N.V. Reddy, Masaru Obokata, Katlyn Koepp, Barry A. Borlaug Tags: 005 Source Type: research

Diagnostic Accuracy of a Precision Medicine Blood Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients with Newly-Diagnosed Heart Failure with Reduced Ejection Fraction - A Pilot Study
In patients with newly-diagnosed heart failure with reduced ejection fraction (HFrEF), current guidelines recommend ischemic workup to rule out the presence of coronary artery disease (CAD), as revascularization in patients with left ventricular systolic dysfunction associated with obstructive CAD is strongly associated with improved survival. This ischemic work-up is based initially on non-invasive testing and, if indicated, invasive coronary angiography (ICA). While non-invasive testing is limited by its low diagnostic yield, ICA exposes patients to radiation, IV contrast and procedural complications. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Michael C. Viray, Daniel Brito, Mohammad N. Zabad, Ebenezer Oni, Vincent Figueredo, Behnam Bozorgnia Tags: 006 Source Type: research

Impact of Epicardial Adipose Tissue in Heart Failure with Preserved Ejection Fraction
Obesity is a strong risk factor for heart failure (HF) with preserved ejection fraction (HFpEF). HFpEF patients with obesity display distinct structural and functional changes in the heart compared to non-obese HFpEF. In addition to generalized obesity, fat distribution may also be important. Prior studies have shown that epicardial adipose tissue (EAT) is associated with inflammation, atrial fibrillation and cardiac fibrosis. Based upon its location, EAT might also influence hemodynamics and ventricular interaction via direct mechanical effects. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Katlyn E. Koepp, Masaru Obokata, Yogesh N. Reddy, Thomas P. Olson, Barry A. Borlaug Tags: 007 Source Type: research

Temporal Changes in Right Ventricular Structure and Function in Patients with Heart Failure and Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is often conceptualized as a primary disorder of the left ventricle (LV). No study has evaluated long-term changes in right ventricular (RV) structure and function in HFpEF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Masaru Obokata, Yogesh N.V. Reddy, Vojtech Melenovsky, Sorin Pislaru, Barry A. Borlaug Tags: 008 Source Type: research

Right Heart Failure during Support with a Left Ventricular Assist Device is Associated with Primary Graft Dysfunction after Heart Transplantation
This study investigated the relationship between RHF while on LVAD support and post-transplant outcomes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Phillip M. King, David S. Raymer, Jerrica E. Shuster, Mallory L. Crain, Joel D. Schilling Tags: 009 Source Type: research

Successful Reduction in the Heart Failure Length of Stay through Standardized Management
As the focus to decrease in-hospitalization medical expenses increases, length of stay (LOS) has become a focal point of analysis particularly in the heart failure (HF) population. This is a reasonable goal as HF is the leading cause of hospital admission in patients older than 65 years old and research has shown that shorter LOS is associated with better outcomes. The purpose of this project was to standardize the management of HF patients and to decrease the HF average length of stay (ALOS) by one day. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Maekal Elyasi, James W. Ciancarelli, Norhan M. Mohammed, Andrew J. Maidhof, Nickolaos Michelakis, Justine S. Lachmann Tags: 010 Source Type: research

Multifaceted Interventions at Skilled Nursing and Long Term Care Facilities Reduce 30 day Heart failure Readmissions
Introduction: Preventing 30 day Heart Failure (HF) readmissions can improve morbidity and mortality, and the financial wellbeing of health care systems. One of the factors affecting readmissions is inconsistent quality of care and adverse outcomes at Skilled Nursing (SNF)/Long term Care (LTAC) facilities/ Home care (after discharge from hospitals). Hypothesis Identifying SNF/LTAC/Home care that are specifically appropriate for HF care and then ensure collaborating facilities undergo HF based training/education, and adhere to HF established protocol will reduce 30 day HF readmissions. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Michaelle Callihan, Srinivas Murali, Alison Neal, Lexi Robinson, Nicole Spellman Kyluck, Azam Hadi Tags: 011 Source Type: research

Patient Perceptions of a Heart Failure Action Plan: A Qualitative Study
Individuals with heart failure have difficulty evaluating their symptoms and understanding when to seek health care or to implement self-care activities. The purpose of this qualitative study is to inform the development of a Heart Failure Action Plan by individuals living with heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Kelley M. Anderson, Rachel Barish, Martha Awoke Tags: 012 Source Type: research

Factors Associated with Heart Failure Self-Care in a Low Socioeconomic Status, Urban Patient Population
Patients with low socioeconomic status (SES) have worse heart failure (HF) outcomes than patients with high SES, including higher readmissions. Interventions to improve outcomes in low SES patient populations have not been successful however the reasons remain unclear. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Carolyn Dickens, Victoria Vaughan-Dickson, Mariann R. Piano Tags: 013 Source Type: research

Changes in Heart Failure Self-care Behaviors and Intrathoracic Impedance over 6 Months.
Poor heart failure (HF) self-care has been shown by others to be associated with lung fluid accumulation measured by intrathoracic impedance. No studies, however, have examined how HF self-care is associated with intrathoracic impedance over time. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Jonathan P. Auld, Christopher S. Lee Tags: 014 Source Type: research

Cardiotoxicity after Cancer Treatment: Comparing Clinical Practice with Guidelines
Cardiotoxicity is an important and disabling consequence of cancer treatment for many cancer survivors. While multiple guidelines now exist, little is known about how well they are operationalized. The aim of this project was to describe the journey through the healthcare system of a group of patients with confirmed cardiotoxicity as a consequence of cancer treatment and to establish baseline data for the implementation evidence based practice. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Robyn A. Clark, Tania S. Marin, John J. Atherton, Julie Bradley, Jonathan Foote, Suchi Grover, Christopher S. Karapetis, Robyn Peters, Sid SelvaNayagam, Bogda Koczwara Tags: 015 Source Type: research

A Simulation-Based Mastery Learning Approach to Ventricular Assist Device Self-Management: The SimVAD Study
Care of ventricular assist devices (VADs) requires meticulous self-management skills by patients and caregivers to enhance competence and prevent adverse events. Simulation-based mastery learning (SBML) is a clinical educational model that uses mannequins to train healthcare providers to a high standard and has been shown to reduce patient complications. SBML has not been used to train patients or caregivers to mastery on required skills. This abstract describes the multidisciplinary development of an innovative patient-centered, VAD self-management SBML curriculum. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Rebecca S. Harap, Kenzie A. Cameron, Gretchen Nonog, Lauren Schulze, Elaine Cohen, Kathleen L. Grady, Jane E. Wilcox, Kerry Shanklin, Clyde W. Yancy, Duc Thinh Pham, Jeffrey H. Barsuk Tags: 016 Source Type: research

Association between Sacubitril/Valsartan Initiation and Health Status Outcomes inHeart Failure with Reduced Ejection Fraction:Findings from the CHAMP-HF Registry
Optimizing patients ’ health status is a primary goal for patients with heart failure and reduced ejection fraction (HFrEF). The association of sacubitril/valsartan (ARNI) with patients’ health status in clinical practice has not been described. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Yevgeniy Khariton, Adrian Hernandez, Gregg C. Fonarow, Puza P. Sharma, Carol I. Duffy, Laine Thomas, Xiaojuan Mi, Xiaojuan Mi, Nancy M. Albert, Javed Butler, Kevin McCague, Michael E. Nassif, Fredonia B. Williams, Adam DeVore, J. Herbert Patterson, John A Tags: 017 Source Type: research