Characteristics and Outcomes of LVAD patients with COVID-19
The pandemic of coronavirus disease 2019 (COVID-19) has afflicted>4 million people in the US and carries a high mortality rate. Preexisting cardiovascular diseases such as coronary artery disease(CAD), hypertension(HTN), diabetes mellitus(DM) and older age have been associated with an increased risk of COVID-19.1 Thromboembolic events are common during COVID-19 infection, and the approach to both prophylactic and therapeutic anticoagulation is not clear 2. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2020 Category: Cardiology Authors: Irina Sobol, Melana Yuzefpolskaya, Zachary Roth, Paolo C. Colombo, Evelyn Horn, Koji Takeda, Gabriel Sayer, Nir Uriel, Yoshifumi Naka Tags: Brief Report Source Type: research

A Short Bridge Over a Wide River: The Role of ECMO in Older Adults with Cardiogenic Shock
Cardiogenic shock remains a challenging, heterogenous clinical entity with high mortality. Despite numerous advances in the treatment of coronary artery disease and cardiac critical care, mortality for patients with cardiogenic shock after acute myocardial infarction (AMI) remains as high as 50%.1-3 The mortality for patients with cardiogenic shock from other etiologies is less clear, but may be higher in some subgroups, such as those with acute on chronic heart failure without options for advanced therapies. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2020 Category: Cardiology Authors: Jonathan D. Wolfe, Joel D. Schilling Source Type: research

The differential impact of the Left Atrial pressure components on Pulmonary Arterial Compliance-Resistance relationship in Heart Failure
: The pulmonary capillary wedge pressure (PAWP) rise has been shown to impact on the inherent relationship between the pulmonary arterial compliance (PAC) and pulmonary vascular resistance (PVR), thus augmenting the pulsatile relative to the resistive load of the right ventricle (RV). However, the PAWP comprises the integration of both the steady and the pulsatile pressure components. We sought to address the differential impact of the these distinct PAWP components on the PAC-PVR relationship in a cohort of heart failure (HF) patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2020 Category: Cardiology Authors: Emil Najjar, Lars H. Lund, Camilla Hage, Anik ó I Nagy, Jonas Johnson, Aristomenis Manouras Source Type: research

Pulsus alternans as a sign of right ventricular failure after left ventricular assist device implantation
Pulsus alternans (PA) is a phenomenon of beat-to-beat alternations in systolic blood pressure caused by variations in stroke volume. The underlying pathophysiology remains incompletely understood. Variation in the inotropic state of the heart is proposed as an underlying mechanism.1 One hypothesis includes a Frank –Starling-induced increase in stroke volume after each low stroke volume beat, which ends with a higher end-systolic volume.1 Abnormal calcium handling has also been suggested as a contributory mechanism. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2020 Category: Cardiology Authors: Balthazar Tim, Adriaenssens Tom, Rega Filip, Vandenbriele Christophe Tags: Brief Report Source Type: research

Heart Failure with preserved Ejection Fraction: Defining phenotypes
Heart failure with preserved ejection (HFpEF) has been increasingly recognized as an epidemic and various phenotypes have now been suggested (1). The clinical presentation as well as medical history may vary in this condition. Some patients experience multifold hospitalizations, and others complain of breathlessness and have a similar decrease in quality of life, but have never been hospitalized. Some patients have severe, recurrent congestion, and others are essentially symptomatic only when exercising. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2020 Category: Cardiology Authors: Erwan DONAL, Guillaume L'OFFICIAL, Wojciech KOSMALA Source Type: research

Cognition, Physical Function and Quality-of-Life in Older Patients with Acute Decompensated Heart Failure
Older adults often experience progressive tandem decrements in cognitive and physical functioning that threaten their independence and quality-of-life (QOL).1,2 The severity of loss in QOL and overall functional ability varies, depending on interactions between aging and comorbid disease processes. Heart failure (HF) is among the most common systemic comorbidities of older adulthood. Given the highly vascularized nature of the brain and systemic effects of HF, particularly on cerebral perfusion, cognitive impairment (CI), may be a key, but clinically underrecognized, feature of HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 17, 2020 Category: Cardiology Authors: Amy M. Pastva, Christina E. Hugenschmidt, Dalane W. Kitzman, M.Benjamin Nelson, Gretchen A. Brenes, Gordon R. Reeves, Robert J. Mentz, David J. Whellan, Haiying Chen, Pamela W. Duncan Source Type: research

Novel BAG3 Variants in African American Patients with Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation-Contraction
We reported 3 novel non-synonymous single-nucleotide variants of Bcl2-associated athanogene 3 (BAG3) in African Americans with heart failure (HF) which are associated with 2-fold increase in cardiac events (HF hospitalization, heart transplant or death). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 17, 2020 Category: Cardiology Authors: Arthur M. Feldman, Jennifer Gordon, JuFang Wang, Jianliang Song, Xue-Qian Zhang, Valerie D. Myers, Dhanendra Tomar, Glenn S. Gerhard, Kamel Khalili, Joseph Y. Cheung Source Type: research

Assessing Prevalence and Characteristics of Rare Disease Cardiomyopathies: A Modest Proposal
Rare diseases, particularly those falling under the rubric of neuromuscular illnesses, present challenges to accurate epidemiologic characterization. Because rare diseases involve rare patients, and epidemiologic assessment requires aggregation of large amounts of patient data including a spectrum of subgroups at risk, accurate evaluation of rare disease incidence, prevalence and risk, as well as therapeutic efficacy, can only be performed well in the context of cooperation between clinician-investigators to accrue data in an unbiased, standardized approach. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 17, 2020 Category: Cardiology Authors: Jonathan F. Plehn Source Type: research

Cardiovascular Magnetic Resonance may avoid unnecessary coronary angiography in patients with unexplained left ventricular systolic dysfunction: a retrospective diagnostic pilot study
Coronary angiography(CA) is usually performed in patients with reduced left ventricular ejection fraction(LVEF) to (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 14, 2020 Category: Cardiology Authors: Louis-Marie Desroche, Olivier Milleron, Benjamin Safar, Phalla Ou, Eric Garbarz, Yoan Lavie-Badie, J érémie Abtan, Damien Millischer, Atul Pathak, Isabelle Durand-Zaleski, Simon Cattan, Thibault Ronchard, Guillaume Jondeau Source Type: research

The effect of decongestion on intrarenal venous flow patterns in acute heart failure patients
Discontinuous intrarenal venous flow patterns, as assessed by renal Doppler ultrasound, are associated with changes in hemodynamics such as volume expansion and poorer diuretic response in patients with HF. We aimed to study intrarenal venous and arterial flow patterns following decongestive treatment in patients with acute heart failure (HF). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 10, 2020 Category: Cardiology Authors: Jozine M. ter Maaten, Jeroen Dauw, Pieter Martens, Frauke Somers, Kevin Damman, Christoph Metalidis, Petra Nijst, Matthias Dupont, Wilfried Mullens Tags: Brief Report Source Type: research

Patterns of Use of Temporary Mechanical Circulatory Support as a Bridge to Transplant During the Coronavirus Disease 2019 (COVID-19) Pandemic
Since implementation of the new donor heart allocation system in October 2018, the proportion of patients bridged with temporary mechanical circulatory support (MCS) has increased drastically.1 In particular, utilization of extracorporeal membrane oxygenation (ECMO) and intraaortic balloon pump (IABP) as a bridge to transplant (BTT) has nearly quadrupled. However, in January 2020, the first case of coronavirus disease 2019 (COVID –19) was reported in the United States and has since given rise to an unprecedented pandemic. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 10, 2020 Category: Cardiology Authors: Taylor Nordan, Gregory S. Couper, Frederick Y. Chen, Amanda Vest, David DeNofrio, Masashi Kawabori Tags: Letter to the Editor Source Type: research

Testing for Chagas disease in an at-risk population
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is endemic to parts of Mexico and Central/South America. Chagas heart disease develops in 20-30% of patients; manifestations include conduction abnormalities (e.g. right bundle branch block [RBBB]), ventricular tachycardia (VT), and progressive dilated cardiomyopathy1. The estimated prevalence of CD in the US exceeds 300,000 people2, and CD accounts for ∼19% of non-ischemic cardiomyopathy3, 7.5% of pacemakers4, and 5% of conduction abnormalities5 among Latin American immigrants in California. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 6, 2020 Category: Cardiology Authors: Alyse E. Wheelock, Sukhmeet K. Sandhu, Alyssa J. Loskill, Rachel R. Marcus, Deepa M. Gopal, Davidson H. Hamer, Natasha S. Hochberg Tags: Research Letter Source Type: research

Response to: Loutradis et al. Longer Dialysis Sessions Improve Cardiac Systolic Function by Reducing Myocardial Stunning
We are grateful for the chance to correspond with Loutradis et al, who reasonably suggest that a decreased volume overload may drive improvement in end-diastolic volume. In response to this idea, we have conducted a further analysis of the ACTIVE Dialysis trial participants to determine if a change in body weight was associated with change in end-diastolic volume, or modified the relationship between this parameter and allocation to extended hours dialysis. As described in detail elsewhere,1,2 95 members of a larger cohort of hemodialysis recipients randomized to extended ( ≥24 hours per week) or standard (12–18 h...
Source: Journal of Cardiac Failure - September 2, 2020 Category: Cardiology Authors: Brendan Smyth, Christopher T Chan, Stuart M Grieve, Rajesh Puranik, Li Zuo, Daqing Hong, Nicholas A Gray, Janak R de Zoysa, Anish Scaria, Martin Gallagher, Vlado Perkovic, Meg Jardine Tags: Letter to the Editor Source Type: research

Uric Acid Is a Biomarker of Oxidative Stress in the Failing Heart: Lessons Learned from Trials With Allopurinol and SGLT2 Inhibitors
Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are seen in patients who have worse ventricular function, functional capacity and prognosis. Heart failure is also accompanied by upregulation of xanthine oxidase, the enzyme that catalyzes the formation of uric acid and a purported source of reactive oxygen species. However, the available evidence does not support the premise that either uric acid or the activation of xanthine oxidase has direct injurious effects on the heart in the clinical setting. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 2, 2020 Category: Cardiology Authors: Milton Packer Source Type: research

Response to: Loutradis, et al. Longer dialysis sessions improve cardiac systolic function by reducing myocardial stunning
We are grateful for the chance to correspond with Loutradis et al. who reasonably suggest that reduced volume overload may drive improvement in end-diastolic volume. In response to this, we have conducted a further analysis of the ACTIVE Dialysis trial participants to determine if a change in body weight was associated with change in end-diastolic volume, or modified the relationship between this parameter and allocation to extended hours dialysis. As described in detail elsewhere,12 95 members of a larger cohort of hemodialysis recipients randomised to extended ( ≥24 hours per week) or standard (12-18 hours per week) h...
Source: Journal of Cardiac Failure - September 2, 2020 Category: Cardiology Authors: Brendan Smyth, Christopher T Chan, Stuart M Grieve, Rajesh Puranik, Li Zuo, Daqing Hong, Nicholas A Gray, Janak R de Zoysa, Anish Scaria, Martin Gallagher, Vlado Perkovic, Meg Jardine Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 1, 2020 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 1, 2020 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 1, 2020 Category: Cardiology Source Type: research

Clinical and imaging response to tumor necrosis factor alpha inhibitors in treatment of cardiac sarcoidosis: a multicenter experience
Sarcoidosis is a systemic granulomatous inflammatory disease. Cardiac involvement has been reported in up to 25% of cases of sarcoidosis. [1] Cardiac sarcoidosis (CS) is a major cause of death in patients with sarcoidosis, and morbidity is associated with granulomatous inflammation which results in conduction disease, ventricular arrhythmia and cardiomyopathy leading to heart failure. [2] The mainstay of medical therapy is immunosuppression in the form of corticosteroids with the possible addition of a steroid sparing agent. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 1, 2020 Category: Cardiology Authors: Nisha A. Gilotra, Alison L. Wand, Anjani Pillarisetty, Mithun Devraj, Noelle Pavlovic, Sara Ahmed, Elie Saad, Lilja Solnes, Carlos Garcia, David R. Okada, Florina Constantinescu, Selma F. Mohammed, Jan M. Griffin, Edward K. Kasper, Edward S. Chen, Farooq Source Type: research

Possible association between body temperature and B-type natriuretic peptide in patients with cardiovascular diseases
Both A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are produced in the heart, and the various biological effects of natriuretic peptides (NPs) on the cardiovascular system play a key role in the pathophysiology of heart failure. NPs classically act on the renal and cardiovascular systems, regulate blood pressure and fluid homeostasis through vasodilatory and diuretic actions, and improve cardiac remodeling.1, 2 (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 29, 2020 Category: Cardiology Authors: Ryeonshi Kang, Tomohisa Nagoshi, Haruka Kimura, Toshikazu D. Tanaka, Akira Yoshii, Yasunori Inoue, Satoshi Morimoto, Kazuo Ogawa, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura Source Type: research

Association of Coronary Microvascular Dysfunction with Heart Failure Hospitalizations and Mortality in Heart Failure with Preserved Ejection Fraction – a follow-up in the PROMIS-HFpEF study
Coronary microvascular dysfunction (CMD) is common in heart failure with preserved ejection fraction (HFpEF). We assessed the association of CMD with hospitalization and mortality in HFpEF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 23, 2020 Category: Cardiology Authors: Camilla Hage, Sara Svedlund, Antti Saraste, Ulrika Ljung Fax én, Lina Benson, Maria Lagerstrom Fermer, Li-Ming Gan, Sanjiv J. Shah, Carolyn S.P. Lam, Lars H. Lund Tags: Brief Report Source Type: research

Chronotropic Incompetence Predicts Distance Walked in Six-Minute Walk Test in Heart Failure with Preserved Ejection Fraction
The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and heterogeneous. Chronotropic incompetence (CI) has emerged as a potential mechanism causally related to proxies of functional capacity impairment.1-4 Distance-walked in 6 minutes test (6-MWT), is a widely available and clinically useful parameter to assess submaximal aerobic capacity.5 In this work, we sought to evaluate whether CI is associated with 6-MWT beyond clinical, echocardiographic, laboratory, and CPET parameters in patients with stable symptomatic HFpEF (NYHA II-III). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 23, 2020 Category: Cardiology Authors: Patricia Palau, Eloy Dom ínguez, Julia Seller, Clara Sastre, Antoni Bayés-Genís, Julio Núñez Tags: Research Letter Source Type: research

Effects of Angiotensin-Neprilysin Inhibition in Canines with Experimentally Induced Cardiorenal Syndrome
This study examined the effects of Sac/Val on LV structure, function, and bioenergetics, and on biomarkers of kidney injury and kidney function in dogs with experimental cardiorenal syndrome. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 21, 2020 Category: Cardiology Authors: Hani N. Sabbah, Kefei Zhang, Ramesh C. Gupta, Jiang Xu, Vinita Singh-Gupta Source Type: research

Effects of Angiotensin-Neprilysin Inhibition in Canines with Experimentally-Induced Cardiorenal Syndrome
This study examined the effects of Sac/Val on LV structure, function and bioenergetics and on biomarkers of kidney injury and kidney function in dogs with experimental cardiorenal syndrome (CRS). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 21, 2020 Category: Cardiology Authors: Hani N. Sabbah, Kefei Zhang, Ramesh C. Gupta, Jiang-Xu, Vinita Singh-Gupta Source Type: research

The Journey Toward Advances in Diuretics Management: Quite Far and Not Far Enough
The earliest report of medicinal diuretic effect dates at least to 1807, when a patient noted diuresis as a side effect of mercury, which he had been taking to treat syphilis (Figure 1). Later reports note success with mercurial treatment of renal or cardiac dropsy.1 It was a time before randomized trials, yet the clinical benefit of diuretics – particularly loop diuretics – in patients with heart failure was so clear, rapid, and potent, relative to previously available therapies, that observational experience convinced most clinicians that diuretics would serve an important role in heart failure management. (S...
Source: Journal of Cardiac Failure - August 20, 2020 Category: Cardiology Authors: Marvin A. Konstam Tags: Editorial Source Type: research

Impact of the Coronavirus Disease-19 Outbreak on Physical Activity of Patients With Implantable Cardioverter Defibrillators
Physical activity (PA) is a cornerstone of prevention to decrease mortality in patients with chronic cardiovascular disease, including heart failure.1,2 Implantable cardiac devices offer the opportunity to monitor PA and data derived from implantable devices have been associated with short- and long-term outcomes.3,4 During the severe acute respiratory syndrome coronavirus 2 pandemic, restrictions to outdoor activity were imposed by national authorities. In Italy, after the first case of coronavirus disease-2019 (COVID-19) on February 21, the so-called lockdown act was passed on March 8, 2020. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 19, 2020 Category: Cardiology Authors: Giovanni Malanchini, Maurizio Malacrida, Paola Ferrari, Cristina Leidi, Gabriele Ferrari, Marco Racheli, Michele Senni, Paolo de Filippo Tags: Research Letter Source Type: research

Sex Differences in the Phenotype of Transthyretin Cardiac Amyloidosis due to Val122Ile Mutation: Insights from Non-Invasive Pressure-Volume Analysis
: Transthyretin cardiac amyloidosis (ATTR-CA) is an under-recognized cause of heart failure with preserved ejection fraction. In the United States, the valine-to-isoleucine substitution (Val122Ile) is the most common inherited variant. Data on sex differences in presentation and outcomes of Val122Ile ATTR-CA are lacking. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 19, 2020 Category: Cardiology Authors: Jaya Batra, Hannah Rosenblum, Ersilia M. DeFilippis, Jan M. Griffin, Sunil E. Saith, Danilo Gamino, Sergio Teruya, Jeffeny De Los Santos, Stephen Helmke, Daniel Burkhoff, Mathew S. Maurer Source Type: research

Impact of COVID-19 outbreak on physical activity of patients with implantable cardioverter defibrillators
Physical activity (PA) is a cornerstone of prevention to decrease mortality in patients with chronic cardiovascular disease including heart failure [1,2]. Implantable cardiac devices offer the opportunity to monitor PA and data derived from implantable devices have been associated with short- and long-term outcomes [3,4]. During the SARS-CoV2 pandemic, restrictions to outdoor activity were imposed by national authorities. In Italy, after the first case of Coronavirus disease –2019 (COVID-19) on February 21st, the so called “lockdown” act was passed on March 8th 2020 [5]. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 19, 2020 Category: Cardiology Authors: Giovanni Malanchini, Maurizio Malacrida, Paola Ferrari, Cristina Leidi, Gabriele Ferrari, Marco Racheli, Michele Senni, Paolo De Filippo Tags: Research Letter Source Type: research

Home-based inspiratory muscle training in patients with heart failure and preserved ejection fraction-a preliminary study-
Inspiratory muscle weakness is associated with exercise intolerance in heart failure with preserved ejection fraction (HFpEF) [1]. However, the beneficial effects of inspiratory muscle training (IMT) for more than 12 weeks in HFpEF remains unclear [2]. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 19, 2020 Category: Cardiology Authors: Yoshiharu Kinugasa, Takeshi Sota, Natsuko Ishiga, Kensuke Nakamura, Hiroko Kamitani, Masayuki Hirai, Kiyotaka Yanagihara, Masahiko Kato, Kazuhiro Yamamoto Tags: Research Letter Source Type: research

Characterization of the Progression from Ambulatory to Hospitalized Heart Failure with Preserved Ejection Fraction
Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Some patients develop elevated filling pressures exclusively during exercise and never require hospitalization, whereas others periodically develop congestion that requires inpatient treatment. The features differentiating these cohorts are unclear. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 19, 2020 Category: Cardiology Authors: Yogesh N.V. Reddy, Masaru Obokata, Aaron D. Jones, Gregory D. Lewis, Sanjiv J. Shah, Omar F. AbouEzzedine, Marat Fudim, Brooke Alhanti, Lynne W. Stevenson, Margaret M. Redfield, Barry A. Borlaug Source Type: research

Looking Rightward in Acute Left Heart Failure
Patient management paradigms in heart failure (HF) are appropriately focused on left ventricular (LV) function, however, right ventricular (RV) structure and function play critical roles in cardiovascular health. Palazzuoli and colleagues report an interesting study in the current issue of the Journal which prospectively enrolled 381 patients presenting with acute HF. (1) The study population included both patients with HF and reduced ejection fraction (HFrEF) and patients with preserved EF (HFpEF). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 18, 2020 Category: Cardiology Authors: John Gorcsan Tags: Editorial Source Type: research

An Orphan Disease No More: Additional Treatment Options for Cardiac Amyloidosis
According to the Federal Drug Administration (FDA), an orphan disease is defined as “a condition that affects fewer than 200,000 people nationwide” [1]. This definition was an amendment to the 1983 Orphan Drug Act, which was passed to incentivize research and development into medications for treatment of orphan diseases through a combination of tax credits, grants, and market-e xclusivity rights regardless of patent status [2]. Transthyretin cardiac amyloidosis (ATTR), caused by misfolding and deposition of the transthyretin tetramer protein (TTR) in the myocardium, and is considered to be an orphan disease. (S...
Source: Journal of Cardiac Failure - August 18, 2020 Category: Cardiology Authors: Nitasha Sarswat Tags: Editorial Source Type: research

Pulmonary Artery Pressure Monitoring during the COVID-19 Pandemic in New York City
Almufleh et al1 describe the impact of the Coronavirus disease 2019 (COVID-19) pandemic on 21 patients with heart failure (HF) monitored by the implantable CardioMEMS-3 system in Massachusetts before and after March 11, 2020, when a state of emergency was declared. Pulmonary artery pressure volatility in the post COVID-19 period increased, with a higher frequency of patients crossing pulmonary artery diastolic thresholds but a concomitant increase in clinician calls and interventions and a reduction in hospitalizations because of HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 14, 2020 Category: Cardiology Authors: Estefania Oliveros, Kiran Mahmood, Sumeet Mitter, Sean P. Pinney, Anuradha Lala Tags: Letter to the Editor Source Type: research

Letter to the Editor: Pulmonary Artery Pressure Monitoring during the COVID-19 Pandemic in New York City
Almufleh. et al 1 describe the impact of the Coronavirus disease 2019 (COVID-19) pandemic on 21 patients with heart failure (HF) monitored with the implantable CardioMEMS-3 system in Massachusetts before and after March 11th 2020 when a state of emergency was declared. Pulmonary artery pressure (PAP) volatility in the post COVID-19 period increased, with higher frequency of patients crossing pulmonary artery diastolic (PAD) thresholds, but concomitant increase in clinician calls and interventions and a reduction in HF hospitalizations. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 14, 2020 Category: Cardiology Authors: Estefania Oliveros, Kiran Mahmood, Sumeet Mitter, Sean P. Pinney, Anuradha Lala Tags: Letter to the Editor Source Type: research

Patient stratification for risk of readmission due to heart failure by using nationwide administrative data
Identifying patients with heart failure (HF) who are most at risk of readmission permits targeting adapted interventions. The use of administrative data enables regulators to support the implementation of such interventions. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 12, 2020 Category: Cardiology Authors: Panayotis Constantinou, Nathalie Pelletier-Fleury, Val érie Olié, Christelle Gastaldi-Ménager, Yves Juillère, Philippe Tuppin Source Type: research

Patient-stratification for risk of heart failure readmission using nationwide administrative data
Identifying heart failure (HF) patients most at-risk of readmission permits targeting adapted interventions. The use of administrative data enables regulators to support the implementation of such interventions. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 12, 2020 Category: Cardiology Authors: Panayotis Constantinou, Nathalie Pelletier-Fleury, Val érie Olié, Christelle Gastaldi-Ménager, Yves Juillère, Philippe Tuppin Source Type: research

Clinical significance of reactive oxidative metabolites in patients with heart failure with reduced left ventricular ejection fraction
We investigated the clinical significance of the derivative of reactive oxygen metabolites (DROM), a new marker of reactive oxygen species (ROS), in heart failure (HF) with reduced left ventricular ejection fraction (LVEF) (HFrEF) patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2020 Category: Cardiology Authors: Taiki Nishihara, Takanori Tokitsu, Daisuke Sueta, Fumi Oike, Masafumi Takae, Koichiro Fujisue, Hiroki Usuku, Miwa Ito, Hisanori Kanazawa, Satoshi Araki, Yuichiro Arima, Seiji Takashio, Taishi Nakamura, Kenji Sakamoto, Satoru Suzuki, Koichi Kaikita, Eiichi Source Type: research

The ACTN3 577XX null genotype is associated with low left ventricular dilation-free survival rate in patients with Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD; MIM No.310200) is the most common inherited muscle disease, estimated to affect approximately 1 out of 3,500 to 5,000 male newborns.1,2 It is a fatal disease diagnosed in childhood and characterized by progressive muscle wasting caused by a mutation in the DMD gene. Affected individuals commonly lose their ability to walk around 10 years after beginning to walk in infancy.3,4 Patients with DMD have multiple complications, of which cardiomyopathy and resultant heart failure is the most common cause of morbidity and mortality. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 10, 2020 Category: Cardiology Authors: Masashi Nagai, Hiroyuki Awano, Tetsushi Yamamoto, Ryosuke Bo, Masafumi Matsuo, Kazumoto Iijima Tags: Research article Source Type: research

Transition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy
Although the use of extracorporeal membrane oxygenation (ECMO) continues to increase, very little is known about how age influences the transition to definitive advanced therapies. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 7, 2020 Category: Cardiology Authors: Fouad Chouairi, Saraschandra Vallabhajosyula, Clancy Mullan, Makoto Mori, Arnar Geirsson, Nihar R. Desai, Tariq Ahmad, P. Elliott Miller Tags: Brief Report Source Type: research

Reconsidering the Diagnostic Criteria of Right Ventricular Primary Graft Dysfunction
Primary graft dysfunction is defined as left and/or right ventricular (RV) failure occurring in the immediate post-transplant period in the absence of an immunologic or anatomic etiology. It is the leading cause of peri-operative mortality among patients receiving heart transplants1 making early and accurate diagnosis critical to optimizing outcomes. Diagnostic criteria were proposed by the International Society of Heart and Lung Transplantation,2 however the diagnosis of right ventricular primary graft dysfunction (RV-PGD) remains controversial. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 7, 2020 Category: Cardiology Authors: Amit Alam, Gregory P. Milligan, Susan M. Joseph Tags: Letter to the Editor Source Type: research

Transition to Advanced Therapies Among Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy
While the utilization of extracorporeal membrane oxygenation (ECMO) continues to increase, very little is known about how age influences the transition to definitive advanced therapies. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 7, 2020 Category: Cardiology Authors: Fouad Chouairi, Saraschandra Vallabhajosyula, Clancy Mullan, Makoto Mori, Arnar Geirsson, Nihar R. Desai, Tariq Ahmad, P. Elliott Miller Source Type: research

Pregnancy after Heart Transplantation
As post-transplant survival improves, many heart transplant (HT) recipients are of, or are surviving to, childbearing age. Solid organ transplant recipients who become pregnant should be managed by a multidisciplinary cardio-obstetrics team including specialists in maternal and fetal medicine, cardiology and transplant medicine, as well as anesthesia, neonatology, psychology, genetics, and social services. With careful patient selection, pregnancy after HT can been managed safely. The purpose of this comprehensive review is to summarize the current evidence and recommendations surrounding pre-conception counseling, medical...
Source: Journal of Cardiac Failure - August 6, 2020 Category: Cardiology Authors: Ersilia M. DeFilippis, Michelle M. Kittleson Source Type: research

Gaps in Comprehensive Smoke-Free Laws and Impact on Heart Failure
In the current issue of the Journal, Psotka et al. (2020) found exposure to second hand smoke (SHS) was associated with an increased risk of all-cause mortality among adults with heart failure.1 Their study contributes to a robust literature on the negative health effects of SHS.2 It also underscores the importance of comprehensive clean indoor air and smoke-free laws as a key public health policy that can reduce the burden of tobacco-associated disease and death. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 3, 2020 Category: Cardiology Authors: Samir Soneji Source Type: research

Lifting Coronavirus Disease-19 Shelter-in-Place Restrictions: Impact on Heart Failure Hospitalizations in Northeast Georgia
During the coronavirus disease-2019 (COVID-19) pandemic, the heart failure (HF) community witnessed unprecedented decreases in HF-related patient visits and hospitalizations. Studies to date have focused on the impact of the initial phase of the COVID-19 lockdown of HF hospitalization trends across multiple countries.1 –4 It is likely that patients with HF, who are at higher risk for morbidity and mortality from COVID-19, delay seeking care in large part owing to anxiety about contracting the virus. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 2, 2020 Category: Cardiology Authors: Hua Ling, Marat Fudim, Ugochukwu O. Egolum Tags: Research Letter Source Type: research

Performance of Electronic Health Record Diagnosis Codes for Ambulatory Heart Failure Encounters
There is interest in leveraging the electronic medical record (EMR) to improve knowledge and understanding of patient characteristics and outcomes of ambulatory heart failure (HF) patients. However, the diagnostic performance of ICD-10 diagnosis codes from the EMR for patients with heart failure with reduced and preserved ejection fraction (HFrEF and HFpEF) in the ambulatory setting are unknown. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 2, 2020 Category: Cardiology Authors: Parag Goyal, Budhaditya Bose, Ruth Masterson Creber, Udhay Krishnan, Mei Yang, Joanne Brady, Jyotishman Pathak Source Type: research

Lifting COVID-19 Shelter-in-Place Restrictions: Impact on Heart Failure Hospitalizations in Northeast Georgia
During the COVID-19 pandemic, the heart failure (HF) community witnessed unprecedented declines in HF-related patient visits and hospitalizations. Studies to date have focused on the impact of the initial phase of the COVID-19 lockdown of HF hospitalization trends across multiple countries.1-4 It is likely that patients with HF, who are at higher risk for morbidity and mortality from COVID-19, delay seeking care in large part due to anxiety about contracting the virus. Nevertheless, the concerns may resolve over time with availability of treatment for COVID-19 and overwhelming HF symptom burden. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 2, 2020 Category: Cardiology Authors: Hua Ling, Marat Fudim, Ugochukwu O. Egolum Tags: Research Letter Source Type: research

Metabolomic Profile in Patients with Heart Failure With Preserved Ejection Fraction Versus Patients With Heart Failure With Reduced Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) are associated with metabolic derangements, which may have different pathophysiological implications. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2020 Category: Cardiology Authors: Camilla Hage, Lars L öfgren, Filippos Michopoulos, Ralph nilsson, Pia Davidsson, Chanchal Kumar, Mattias Ekström, Maria J. Eriksson, Patrik Lyngå, Bengt Persson, Hakan Wallén, Li Ming Gan, Hans Persson, Cecilia Linde Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2020 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2020 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2020 Category: Cardiology Source Type: research