Making the Case for an Expanded Indication for Sacubitril/valsartan in Heart Failure
On December 15, the FDA convened an advisory committee to consider whether the results of the PARAGON-HF trial, which compared sacubitril/valsartan to valsartan in patients with heart failure and LVEF of 45% or greater, warranted a new indication for sacubitril/valsartan. In presenting the results of the trial and a perspective on these results, we argued that despite narrowly missing statistical significance for its primary endpoint, the PARAGON-HF data were compelling enough to justify expansion of the current indication for sacubitril/valsartan to include patients with heart failure whose ejection fractions were less th...
Source: Journal of Cardiac Failure - April 15, 2021 Category: Cardiology Authors: Scott D. Solomon, John J.V. McMurray Source Type: research

Cardiac thyrotropin-releasing hormone (TRH) inhibition improves ventricular function and reduces hypertrophy and fibrosis after myocardial infarction in rats.
Thyrotropin-releasing hormone (TRH) is a small neuropeptide (p-Glu-His-Pro-NH2) initially identified in the hypothalamus. The TRH gene (Trh in rodents) encodes a TRH precursor with several copies of the tripeptide, the number of which depends on the species. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 15, 2021 Category: Cardiology Authors: Mariano L. Schuman, Ludmila S. Peres Diaz, Maia Aisicovich, Fernando Ingallina, Jorge E. Toblli, Maria S. Landa, Silvia I. Garc ía Source Type: research

Estimation of stressed blood volume in patients with cardiogenic shock from acute myocardial infarction and decompensated heart failure
: Sympathetically mediated re-distribution of blood from the unstressed venous reservoir to the hemodynamically active stressed compartment is thought to contribute to congestion in cardiogenic shock. We employed a novel computational method to estimate stressed blood volume in cardiogenic shock and assess its relationship with clinical outcomes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 13, 2021 Category: Cardiology Authors: Evan H. Whitehead, Katherine L. Thayer, Kenji Sunagawa, Jaime Hernandez-Montfort, A. Reshad Geran, Manreet Kanwar, Shashank Sinha, Claudius Mahr, Navin K Kapur, Daniel Burkhoff Source Type: research

Profile of Patients Hospitalized for Heart Failure Who Leave Against Medical Advice
There is a paucity of information on patients hospitalized with heart failure [HF] who leave against medical advice [AMA]. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 13, 2021 Category: Cardiology Authors: Judith E. Mitchell, Roseann Chesler, Shuaiqi Zhang, Roland A. Matsouaka, Adam D. DeVore, Larry A. Allen, Nancy M. Albert, Marilyn Fraser, Clyde W. Yancy, Nai-Lun Chang, Gregg C. Fonarow Source Type: research

The Universal Definition of Heart Failure: Strengths and Opportunities
We applaud the authors of the consensus statement on the Universal Definition and Classification of Heart Failure (HF) recently published in the Journal of Cardiac Failure. (1) The universal definition of HF is clinically relevant with prognostic and therapeutic validity, particularly in regards to the important consideration of trajectory in the assessment of HF with EF 41-49% and the emphasis on the contribution of non-cardiovascular entities in patients with congestion. However, the framework of HF with preserved EF (HFpEF) presented in the consensus statement offers opportunity for clarification and more detailed class...
Source: Journal of Cardiac Failure - April 10, 2021 Category: Cardiology Authors: Dmitry Abramov, Michelle M. Kittleson Tags: Editorial Source Type: research

Changes of Right Ventricular Function after Transcatheter Aortic Valve Replacement and Association with Outcome
: Baseline right ventricular (RV) dysfunction represents a predictor for poor outcome in patients undergoing transcatheter aortic valve replacement (TAVR). However, RV function may improve after TAVR, which could have important implications on outcome. The aim of the present study was to assess changes in RV function after TAVR and its prognostic value regarding clinical outcome. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 8, 2021 Category: Cardiology Authors: Felix Poch, Ruth Thalmann, Ida Olbrich, Carmen Fellner, Anja Stundl, Petra Barthel, Christian Bradaric, Karl-Ludwig Laugwitz, Christian Kupatt, Jakob Ledwoch Source Type: research

Iron deficiency is associated with impaired biventricular reserve and reduced exercise capacity in patients with unexplained dyspnea.
Iron deficiency (ID) is frequent and associated with diminished exercise capacity in heart failure (HF), but its contribution to unexplained dyspnea without a HF diagnosis at rest remains unclear. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 7, 2021 Category: Cardiology Authors: Pieter Martens, Guido Claessen, Alexander Van De Bruaene, Frederik H. Verbrugge, Lieven Herbots, Paul Dendale, Jan Verwerft Source Type: research

The Role of Intravascular Ultrasound in Heart Transplant Recipients in the Modern Era
Cardiac allograft vasculopathy (CAV) is the Achilles ’ heel of heart transplantation. An insidious process of panvascular, fibrointimal proliferation, CAV results in chronic ischemia, restrictive physiology, reduced left ventricular function, arrhythmias, and sudden death. CAV is the second most common cause of death after malignancy in heart transp lant recipients more than 1 year post transplantation and is also the leading indication for retransplantation. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Authors: Michelle M., Kittleson Tags: Editorial Source Type: research

Reorienting Ourselves to Delirium: Caring for Older Patients Hospitalized With Heart Failure
Caring for older patients hospitalized with heart failure is increasingly complex. Clinicians are often managing not only an acute heart failure exacerbation, but also multiple comorbidities, polypharmacy, and psychosocial needs. One additional, and often overlooked, condition affecting patients with heart failure is delirium. Delirium is common in hospitalized older adults; yet, its diagnosis, management, and, most important, prevention, remain poorly understood. Delirium is associated with an increase in mortality, complications, length of stay, and likelihood of discharge to a postacute nursing facility and can persist ...
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Authors: Meg T. Fraser, Colleen K. Mcilvennan Tags: Editorial Source Type: research

Contemplation from Our Hearts: A Call to Shift From Failure to Function
Few words in the English language universally invoke the negative emotions of fear and disappointment as does the word “failure”. Conversely, its antonym, “success”, denotes positive sentiments of triumph and fulfillment like none other. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Authors: Anuradha Lala, Robert J. Mentz Tags: Editor's Page Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Source Type: research

PCSK9 Inhibitors in Heart Transplant Patients: Safety, Efficacy, and Angiographic Correlates
Proprotein Convertase Subtilisin/Kexin type-9 inhibitors (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 19, 2021 Category: Cardiology Authors: Yasser Sammour, Christopher DeZorzi, Bethany A Austin, A Michael Borkon, Mark P Everley, Timothy J Fendler, Taiyeb M Khumri, Stephanie L Lawhorn, Michael E Nassif, Deepthi Vodnala, Anthony Magalski, Andrew C Kao, Brett W. Sperry Source Type: research

Universal Definition and Classification of Heart Failure: Is It universal? Does It Define Heart Failure?
A milestone event in heart failure (HF) has occurred. For the first time, a universal definition of HF has emerged via the aggregate efforts of representatives from the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, and Japanese Heart Failure Society with endorsement by Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and the Chinese Heart Failure Association. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 15, 2021 Category: Cardiology Authors: CAROLYN S.P. LAM, CLYDE YANCY Source Type: research

Universal Definition and Classification of Heart Failure Is it universal? Does it define heart failure?
A milestone event in heart failure (HF) has occurred. For the first time, a universal definition of HF has emerged via the aggregate efforts of representatives from the HF Society of America, HF Association of the European Society of Cardiology and Japanese HF Society with endorsement by Canadian HF Society, HF Association of India, Cardiac Society of Australia and New Zealand, and the Chinese HF Association. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 15, 2021 Category: Cardiology Authors: Carolyn S.P. Lam, Clyde Yancy Source Type: research

The Cost-Effectiveness of Palliative Care: Insights from the PAL-HF Trial
In a randomized control trial, Palliative Care in Heart Failure (PAL-HF) improved heart failure (HF) related quality of life, though cost-effectiveness remains unknown. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 14, 2021 Category: Cardiology Authors: Brystana G. Kaufman, Bradi B. Granger, Jie-Lena Sun, Gillian Sanders, Donald H. Taylor, Daniel B. Mark, Haider Warraich, Mona Fiuzat, Karen Steinhauser, James A. Tulsky, Joseph G. Rogers, Christopher O'Connor, Robert J. Mentz Source Type: research

Heart Failure Specialty Certification: A Standard of Excellence
Specialty board certification for physicians and nurses has been available for many years. The American Board of Medical Specialties – American Board of Internal Medicine has an Advanced Heart Failure and Transplant Cardiology certification that requires 3 years of specialty training before application. Providers are evaluated on optimal management of heart failure, including advanced heart failure management (ventricular assis t devices, and pre and post cardiac transplantation). Nurses in the field of heart failure can be certified as a heart failure nurse through the American Association of Heart Failure Nurses. (...
Source: Journal of Cardiac Failure - March 5, 2021 Category: Cardiology Authors: Nancy M. Albert Source Type: research

The Universal Definition of Heart Failure: Perspectives from Diverse Stakeholders
The “Universal Definition and Classification of Heart Failure” goes “live” in the Journal of Cardiac Failure on March 1, 2021. With its debut comes the tremendous opportunity (and responsibility) to fully address its potential impact for the future of heart failure clinical care, research, and a dvocacy. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2021 Category: Cardiology Authors: Robert J. Mentz, Anuradha Lala Source Type: research

Universal Definition and Classification of Heart Failure
In this document, we propose a universal definition of heart failure (HF) as the following: HF is a clinical syndrome with symptoms and or signs caused by a structural and/or functional cardiac abnormality and corroborated by elevated natriuretic peptide levels and or objective evidence of pulmonary or systemic congestion. We propose revised stages of HF as follows. At-risk for HF (Stage A), for patients at risk for HF but without current or prior symptoms or signs of HF and without structural or biomarkers evidence of heart disease. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2021 Category: Cardiology Authors: Biykem Bozkurt, Andrew JS Coats, Hiroyuki Tsutsui, Magdy Abdelhamid, Stamatis Adamopoulos, Nancy Albert, Stefan D. Anker, John Atherton, Michael B öhm, Javed Butler, Mark H. Drazner, G. Michael Felker, Gerasimos Filippatos, Gregg C. Fonarow, Mona Fiuzat, Tags: Consensus Statement Source Type: research

The Universal Definition of Heart: Perspectives From Diverse Stakeholders
The “Universal Definition and Classification of Heart Failure” goes “live” in the Journal of Cardiac Failure on March 1, 2021. With its debut comes the tremendous opportunity (and responsibility) to fully address its potential impact for the future of heart failure clinical care, research, and a dvocacy. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2021 Category: Cardiology Authors: Robert J. Mentz, Anuradha Lala Source Type: research

Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Arterial Stiffness and Aabnormal Left Ventricular Hemodynamic Responses During Exercise
Arterial stiffness is thought to contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). We sought to examine arterial stiffness in HFpEF and hypertension and investigate associations of arterial and left ventricular hemodynamic responses to exercise. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 26, 2021 Category: Cardiology Authors: Emily K. Zern, Jennifer E. Ho, Lindsay G. Panah, Emily S. Lau, Elizabeth Liu, Robyn Farrell, John A. Sbarbaro, Mark W. Schoenike, Paul P. Pappagianopoulos, Mayooran Namasivayam, Rajeev Malhotra, Matthew Nayor, Gregory D. Lewis Source Type: research

Generalizability of HFA-PEFF and H2FPEF Diagnostic Algorithms and Associations with Heart Failure Indices and Proteomic Biomarkers: Insights from PROMIS-HFpEF
Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging. We aimed to evaluate the generalizability of the HFA-PEFF and H2FPEF diagnostic algorithms and associations with HF severity, coronary microvascular dysfunction and proteomic biomarkers. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 26, 2021 Category: Cardiology Authors: Ulrika Ljung-Faxen, Ashwin Venkateshvaran, Sanjiv J. Shah, Carolyn S.P. Lam, Sara Svedlund, Antti Saraste, Lauren Beussink-Nelson, MariaLagerstrom Fermer, Li-Ming Gan, Camilla Hage, Lars H Lund Source Type: research

Patterns of Change in Individual Domains of the Kansas City Cardiomyopathy Questionnaire with a Palliative Care Intervention for Patients with Advanced Heart Failure: Insights from PAL-HF
The Palliative Care in Heart Failure (PAL-HF) trial demonstrated that palliative care (PC) improved health-related quality of life (QOL) in advanced heart failure (HF) patients as measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ), yet less is known about how PC affects the individual domains (physical function, QOL, social limitations, and total symptoms) within the KCCQ overall summary score (1,2). Moreover, since KCCQ changes over time are commonly grouped by small, medium, and large changes (20, respectively), there is interest in understanding how specific domains may contribute differently based on the m...
Source: Journal of Cardiac Failure - February 26, 2021 Category: Cardiology Authors: Luxi Wan, Marc D. Samsky, Christopher M. O'Connor, Amanda Stebbins, Brooke Alhanti, Haider J. Warraich, Kimberly S. Johnson, Kevin J. Anstrom, Mona Fiuzat, Bradi B. Granger, Daniel B. Mark, James A. Tulsky, Joseph G. Rogers, Robert J. Mentz Tags: Research Letter Source Type: research

Exercise intolerance in HFpEF: arterial stiffness and abnormal left ventricular hemodynamic responses during exercise
Arterial stiffness is thought to contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). We sought to examine arterial stiffness in HFpEF and hypertension and investigate associations of arterial and left ventricular hemodynamic responses to exercise. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 26, 2021 Category: Cardiology Authors: Emily K. Zern, Jennifer E. Ho, Lindsay G. Panah, Emily S. Lau, Elizabeth Liu, Robyn Farrell, John A. Sbarbaro, Mark W. Schoenike, Paul P. Pappagianopoulos, Mayooran Namasivayam, Rajeev Malhotra, Matthew Nayor, Gregory D. Lewis Source Type: research

Dynamic Assessment of Pulmonary Artery Pulsatility Index Provides Incremental Risk Assessment for Early Right Ventricular Failure after Left Ventricular Assist Device
Heart Failure (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 25, 2021 Category: Cardiology Authors: Matthew H. Gonzalez, Qiuqing Wang, Dmitry M. Yaranov, Chony Albert, Kathy Wolski, John Wagener, Appas Aggarwal, Venu Menon, Miriam Jacob, Wilson Tang, Eileen Hsich, David Taylor, Michael Tong, Edward Soltesz, Jerry D Estep, Randall C Starling, Emer Joyce Source Type: research

Impact of Cardiac Resynchronization Therapy on Global and Cardiac Metabolism and Cardiac Mitochondrial Function
Alterations in myocardial mitochondrial function and metabolism have been implicated in the pathophysiology of heart failure with reduced ejection fraction (HFrEF). The impact of mechanical dyssynchrony and its alleviation through cardiac resynchronization therapy (CRT) on myocardial mitochondrial function and metabolism remain poorly understood. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 24, 2021 Category: Cardiology Authors: Pieter Martens, Matthias Dupont, Pieter Vermeersch, Jeroen Dauw, Petra Nijst, Virginie Bito, Liesbet Mesotten, Joris Penders, Stefan Janssens, W.H. Wilson Tang, Wilfried Mullens Source Type: research

Did You Forget to Assess Cognition in Your Patient With Heart Failure, and Does It Matter?
Heart failure is predominately a disease of older patients with multiple chronic conditions, disability, and frailty. Along with these more physical domains, cognitive issues also arise. In this issue of the Journal of Cardiac Failure, data are presented from a cohort of patients participating in an ongoing randomized trial of a physical intervention.1 The study enrolled participants near the end of a hospitalization for decompensated heart failure, after stabilization. The authors assessed cognition with the Montreal Cognitive Assessment (MoCA), function with the short physical performance battery and a 6-minute walk dist...
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Timothy J. Fendler, Larry A. Allen, Daniel D. Matlock Tags: Editorial Source Type: research

Diversity, Equity and Inclusion at the Journal of Cardiac Failure
In settling into our leadership roles at the Journal of Cardiac Failure (JCF), we have been struck by the tremendous potential for positive influence and change that the journal holds. To realize this potential however, requires a strong foundation of shared values and goals that guide our team and enhance engagement with the heart failure (HF) community. February marked not only American Heart Month but also Black history month and at JCF we were proud to devote content to the vulnerable intersection of Pregnancy and Heart Failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Robert J. Mentz, Anuradha Lala Tags: Editor's Page Source Type: research

Dr. Barry Michael Massie
died at the age of 76 years in Belmont, CA on January 8, 2021. He battled dementia for many years and finally succumbed to complications of COVID-19. Barry grew up in St. Louis, the son of Edward (a prominent cardiologist in his own right) and Felice Massie. He was an undergraduate at Harvard and then attended Columbia University Medical School. He completed residency training and was Chief Medical Resident at Bellevue Hospital, NYU under the mentorship of Dr. Saul Farber. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Source Type: research

Primary Prevention Implantable Cardioverter-Defibrillator Therapy in Heart Failure with Recovered Ejection Fraction
Given recent advances in both pharmacologic and nonpharmacologic strategies for improving outcomes related to chronic systolic heart failure, heart failure with recovered ejection fraction (HFrecEF) is now recognized as a distinct clinical entity with increasing prevalence. In many patients who once had an indication for active implantable cardioverter-defibrillator (ICD) therapy, questions remain regarding the usefulness of this primary prevention strategy to protect against syncope and cardiac arrest after they have achieved myocardial recovery. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Jayson R. Baman, Kaustubha D. Patil, Ankit N. Medhekar, Jane E. Wilcox Source Type: research

Increased Aortic Stiffness Is Associated With Higher Rates of Stroke, Gastrointestinal Bleeding and Pump Thrombosis in Patients With a Continuous Flow Left Ventricular Assist Device
In the general population, increased aortic stiffness is associated with an increased risk of cardiovascular events. Previous studies have demonstrated an increase in aortic stiffness in patients with a continuous flow left ventricular assist device (CF-LVAD). However, the association between aortic stiffness and common adverse events  is unknown. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Hannah Rosenblum, Alberto Pinsino, Amelia Zuver, Azka Javaid, Giulio Mondellini, Ruiping Ji, John R. Cockcroft, Melana Yuzefpolskaya, A. Reshad Garan, Sofia Shames, Veli K. Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Barry J. Mcdonnell, Joshua Z Tags: Brief Report Source Type: research

Primary Prevention ICD Therapy in Heart Failure with Recovered Ejection Fraction
Given recent advances in both pharmacologic and non-pharmacologic strategies for improving outcomes related to chronic systolic heart failure, heart failure with recovered ejection fraction (HFrecEF) is now recognized as a distinct clinical entity with increasing prevalence. In many patients who once had an indication for active implantable cardioverter-defibrillator (ICD) therapy, questions remain regarding the utility of this primary prevention strategy to protect against syncope and cardiac arrest after they have achieved myocardial recovery. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Jayson R. Baman, Kaustubha D. Patil, Ankit N. Medhekar, Jane E. Wilcox Source Type: research

Increased Aortic Stiffness is Associated with Higher Rates of Stroke, GI-bleeding and Pump Thrombosis in CF-LVAD Patients
In the general population, increased aortic stiffness is associated with an increased risk of cardiovascular events. Previous studies have demonstrated an increase in aortic stiffness in continuous-flow left ventricular assist device (CF-LVAD) patients. However, the association between aortic stiffness and common adverse events  is unknown. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Hannah Rosenblum, Alberto Pinsino, Amelia Zuver, Azka Javaid, Giulio Mondellini, Ruiping Ji, John R. Cockcroft, Melana Yuzefpolskaya, A. Reshad Garan, Sofia Shames, Veli K. Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Barry J. McDonnell, Joshua Z Tags: Brief Report Source Type: research

Association of baseline diuretic use with cardiovascular outcomes in patients with heart failure with preserved ejection fraction: A secondary analysis from TOPCAT
The key driver of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) is congestion. While patients with HFpEF are often treated with multiple diuretics including loop, thiazide, and mineralocorticoid receptor antagonists (MRA), only MRAs have been studied in a multi-center randomized controlled setting in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial [TOPCAT]. In TOPCAT, patients with HFpEF randomized to MRA (spironolactone) compared with placebo had a lower rate of hospitalization for heart failure (HHF) (hazard ratio [HR] 0.83; ...
Source: Journal of Cardiac Failure - February 23, 2021 Category: Cardiology Authors: Sadiya S. Khan, Mark D. Huffman, Katherine Harrington, Abigail S. Baldridge, Jie Yu, Bruce Neal, Clare Arnott, Sanjiv J. Shah Tags: Research Letter Source Type: research

Optimized Medical Therapies in Heart Failure with Reduced Ejection Fraction: It Takes Two to Tango
When health care professionals speak about optimized medical therapies, I often wonder how they are defining them. Is the definition based on up-to-date research publication findings of patient outcomes plus individual patient tolerability, side effects, and stated preferences? Or is it defined based on pragmatic situations that may not be ideal: the frequency of office visits, provider type, patient verbalizations for the latest treatment, patient verbalization to do everything that can be done, the rate of hospitalization over a specific period of time, or inaccurate or outdated perceptions that may not be evidence based...
Source: Journal of Cardiac Failure - February 15, 2021 Category: Cardiology Authors: Nancy M. Albert Source Type: research

Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials
Despite a temporal increase in respiratory failure in patients hospitalized with acute heart failure (HF), clinical trials have largely not reported the incidence or associated clinical outcomes for patients requiring mechanical ventilation (MV). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 5, 2021 Category: Cardiology Authors: P. Elliott Miller, Sean van Diepen, Thomas S. Metkus, Carlos L. Alviar, Erin Rayner-Hartley, Sarah Rathwell, Jason N. Katz, Justin Ezekowitz, Nihar R. Desai, Tariq Ahmad Tags: Brief Report Source Type: research

Nonresponse to Acute Vasodilator Challenge and Prognosis in Heart Failure With Pulmonary Hypertension
An acute vasodilator challenge is recommended in patients with heart failure and pulmonary hypertension during heart transplant evaluation. The aim of the study was to assess which hemodynamic parameters are associated with nonresponsiveness to the challenge. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 4, 2021 Category: Cardiology Authors: Stefano Ghio, Gabriele Crimi, Brian Houston, Claudio Montalto, Andrea Garascia, Massimo Boffini, Pier luigi Temporelli, Maria Teresa Larovere, Giuseppe Pacileo, Kavin Panneerselvam, Caterina Santolamazza, Luciana D'angelo, Martina Moschella, Laura Scelsi, Tags: Clinical paper Source Type: research

Non-response to acute vasodilator challenge and prognosis in heart failure with pulmonary hypertension
In left heart disease (LHD), pulmonary hypertension (PH) develops in response to a passive backward transmission as a result of increased left ventricular filling pressures.1 The long-standing consequences of passive pressure transmission end into a vascular disease process driven by a combination of factors additive to the high pressure load such as vasoconstriction, chronic venous congestion and activation of smooth muscle growth factors, altogether promoting vascular remodeling, increased resistive load, right heart failure and worse outcome. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 4, 2021 Category: Cardiology Authors: Stefano Ghio, Gabriele Crimi, Brian Houston, Claudio Montalto, Andrea Garascia, Massimo Boffini, Pierluigi Temporelli, Maria Teresa Larovere, Giuseppe Pacileo, Kavin Panneerselvam, Caterina Santolamazza, Luciana D'Angelo, Martina Moschella, Laura Scelsi, Tags: Clinical paper Source Type: research

Pregnancy With a Ventricular Assist Device: A Systematic Review of the Existing Literature
We report here a systematic review of the literature describing pregnancy in these patients. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Authors: Lauren E. Meece, Ki Park, Tony S. Wen, Eric I. Jeng, Mustafa M. Ahmed Tags: Research Letter Source Type: research

Heart Failure and Pregnancy: Thinking Beyond Peripartum Cardiomyopathy
Cardiovascular disease is currently the leading cause of maternal mortality in the United States, accounting for more than 25% of maternal deaths.1 Cardiomyopathy accounts for 11% of overall maternal deaths, and 32% of late maternal deaths.1,2 Heart failure is also the most common indication for postpartum cardiovascular hospitalization.3 Early identification of women who are at risk of developing heart failure symptoms and prompt recognition and treatment of symptomatic heart failure are critical steps in addressing the cardiovascular contribution to maternal morbidity and mortality. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Authors: Kathryn J. Lindley Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Source Type: research

Shining a light on the vulnerable intersection of pregnancy and heart failure
Few “normal” processes are as profound as that of expecting new life during pregnancy. It is a time of simultaneous excitement and hope, but also of vulnerability, which may involve fears of potential complications. Sadly, even in 2021, cardiovascular disease is the most common cause of death during pregnancy in developed countries.1 Heightened physiologic stress and perturbed hemodynamics may unmask underlying cardiovascular disease or provoke new pathologic manifestations; one of the most severe of which is heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Authors: Anuradha Lala, Robert J. Mentz Tags: Editor's Page Source Type: research

Pregnancy and Heart Failure: A Special Issue of the Journal of Cardiac Failure
It is a great pleasure to serve as guest editors for this special issue on heart failure and pregnancy, and even more of a pleasure to have the Journal acknowledge the importance of shining a light on this issue. Maternal mortality is steadily rising in the United States, and is marked by stark racial and other sociodemographic disparities.1 Importantly, heart failure is a major contributor to maternal morbidity and mortality – responsible for nearly half of late maternal deaths and a common complication in pregnant and postpartum women with underlying risk factors such as congenital heart disease, valvular heart dis...
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Authors: Kathryn J. Lindley, Mary Norine Walsh Source Type: research

Peripartum Cardiomyopathy and Pregnancy-Associated Heart Failure with Preserved Ejection Fraction: More Similar Than Different
It is an ugly truth that the United States has the highest maternal mortality rate among developed countries.1 Indeed, at 17.4 maternal deaths per 100,000 live births, maternal mortality is twice as high in the U.S. as in any other developed country.1 Even worse, the maternal mortality is rising in the U.S., whereas it is stable or declining in most other countries – including developing countries. According to the World Health Organization, maternal mortality worldwide dropped by 38% from 2000-2017, but increased by 58% in the U.S. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2021 Category: Cardiology Authors: Michael W. Rich Tags: Editorial Source Type: research