Improving selection of MitraClip ® candidates in advanced chronic heart failure. Look right to predict right.
The benefit of MitraClip in patients with advanced chronic heart failure (ACHF) is uncertain since patients with severe left ventricular function may continue to have a poor prognosis despite successful MR correction. There is a need to identify which patients with ACHF and severe functional MR are likely to benefit from the procedure in order to avoid futile procedures. In this multicenter prospective study we sought to evaluate preoperative predictors of improvement after MitraClip. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 13, 2019 Category: Cardiology Authors: Simone Frea, Gabriele Crimi, Oliver Gaemperli, Stefano Pidello, Claudia Raineri, Fabrizio D'Ascenzo, Valeria Crescio, Paolo Boretto, Valeria Gritti, Francesca Giordana, Giulia Magrini, Sara Rettegno, Fabrizio Gazzoli, Alessandra Rabajoli, Antonio Montefus Tags: Research Letter Source Type: research

National Outcomes in Hospitalized Patients with Cancer and Comorbid Heart Failure
Heart disease and cancer are the most common causes of morbidity and mortality in the United States and together account for 1,229,772 (or 46.8%) of all deaths1. Heart failure (HF) alone afflicts 6.5 million people in the United States2. Heart disease and cancer share multiple risk factors such as age, tobacco use, diet, and lack of physical activity, and therefore the two conditions frequently coexist. Additionally, many effective and life prolonging chemotherapeutic agents may result in substantial cardiotoxicity leading to symptoms of cardiac dysfunction3. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 12, 2019 Category: Cardiology Authors: Mirela Tuzovic, Eric H. Yang, Ren é R. Sevag Packard, Patricia A. Ganz, Gregg C. Fonarow, Boback Ziaeian Source Type: research

Eyeing autonomic dysregulation in heart failure
The autonomic nervous system plays an integral role in cardiovascular physiology, and autonomic dysregulation (AD) contributes to the pathophysiology of many cardiovascular disorders. AD in patients with heart failure (HF), consisting primarily of sympathetic up-regulation, parasympathetic down-regulation, and abnormal cardiovascular reflexes, is associated with poor outcomes, and has been the target of many interventional studies.1 (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 12, 2019 Category: Cardiology Authors: Khalil Murad, Mark Dunlap Tags: Brief Report Source Type: research

(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease
The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle region peptide (HRP), on chronic kidney disease (CKD)-associated heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 12, 2019 Category: Cardiology Authors: Akihiro Yoshida, Hiromitsu Kanamori, Genki Naruse, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Atsushi Mikami, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi Tags: Basic Science and Experimental Studies Source Type: research

The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Duchenne Muscular Dystrophy Cardiomyopathy
Duchenne muscular dystrophy (DMD) is an X-linked disorder affecting 1 in 4700 male births.1 Although perceived primarily as a skeletal myopathy, boys also develop insidious and progressive cardiomyopathy. In the current era, cardiomyopathy is the leading cause of mortality.2 Because of skeletal muscle weakness, boys with cardiomyopathy are usually asymptomatic until they develop severe left ventricular (LV) dysfunction. Cardiac imaging is the primary modality for diagnosis of dysfunction. Unfortunately, standard heart failure biomarkers, such as brain natriuretic peptide (BNP), are only increased at end stage. (Source: Jou...
Source: Journal of Cardiac Failure - February 11, 2019 Category: Cardiology Authors: Jonathan H Soslow, Meng Xu, James C Slaughter, Kimberly Crum, Joshua D Chew, W Bryan Burnette, Yan Ru Su, Kelsey Tomasek, David A Parra, Larry W Markham Tags: Clinical Investigation Source Type: research

Resting Oxygen Consumption and Heart Failure: Importance of Measurement for Determination of Cardiac Output Using the Fick Principle
Resting oxygen consumption (VO2) is often estimated and frequently used to guide therapeutic decisions in symptomatic heart failure (HF) patients. The relationship between resting VO2 and symptomatic HF and the accuracy of estimations of VO2 in this population are unknown. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 9, 2019 Category: Cardiology Authors: Gillian Grafton, Thomas Cascino, Daniel Perry, Carmel Ashur, Todd M. Koelling Source Type: research

Diastolic Intra-Left Ventricular Pressure Difference During Exercise: Strong Determinant and Predictor of Exercise Capacity in Patients with Heart Failure
Limited exercise capacity is a major symptom and cause of disability in patients with chronic heart failure (HF). Moreover, exercise intolerance has been reported to be associated with poor prognosis in HF patients.1,2 The exercise capacity is known to be maintained by the increase of cardiac output during exercise in HF regardless of left ventricular (LV) ejection fraction (EF).3 In normal conditions, during exercise, LV suction augments the pressure fall in the LV cavity in early diastole and the generated early-diastolic intra-left ventricular pressure difference (IVPD) pulls blood from left atrium to the LV apex, which...
Source: Journal of Cardiac Failure - February 9, 2019 Category: Cardiology Authors: Shingo Tsujinaga, Hiroyuki Iwano, Miwa Sarashina, Taichi Hayashi, Michito Murayama, Ayako Ichikawa, Masahiro Nakabachi, Hisao Nishino, Shinobu Yokoyama, Arata Fukushima, Takashi Yokota, Kazunori Okada, Sanae Kaga, Pavlos P. Vlachos, Toshihisa Anzai Source Type: research

Driving Pulseless: A driving survey of patients with LVADs and their providers
With the introduction of left ventricular assist devices (LVADs), the patient with advanced heart failure may experience extended and improved quality of life. This growing population is now raising unique questions for the medical community regarding limitations and safety. Of interest is the subject of driving with an LVAD. In 2012 the Canadian Cardiovascular Society indicated that stable patients supported with an LVAD may resume driving 2 months after implantation.1 However, no consensus recommendation currently exists for the United States ’ LVAD population. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 9, 2019 Category: Cardiology Authors: Emily Seif Tags: Research Letter Source Type: research

Reply to Notarius
We thank Dr. Notarius for her interest in our recent article,1 and for bringing her prior excellent work2,3 to our attention. The hypothesis that she puts forth – i.e., that lower muscle sympathetic nerve activity (MSNA) explains why we found that dietary nitrate (NO3−) increased VO2 peak and exercise tolerance in patients with heart failure with reduced ejection fraction (HFrEF) of non-ischemic origin,1 whereas Hirai et al.4 observed no such effect in patients with HFrEF primarily due to ischemia – is clearly quite plausible. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 9, 2019 Category: Cardiology Authors: Andrew R. Coggan, Linda R. Peterson Tags: Letter to the Editor Source Type: research

Empagliflozin targeting the real-world heart failure population
Heart Failure (HF) is a complex syndrome further aggravated by diabetes mellitus (DM). In the EMPA-REG OUTCOME trial, enrolling 7020 patients with diabetes and established cardiovascular (CV) disease, HbA1c 7.0-10% and estimated glomerular filtration rate (eGFR) ≥30mL/min/1.73m2, empagliflozin significantly reduced hospitalization for HF1. However, only 10.1% had HF at baseline. We aimed to investigate whether patients with diabetes admitted for decompensated HF in a “real-world” setting would be enrolled per the trial's main key inclusion and exclusi on criteria. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 8, 2019 Category: Cardiology Authors: Bruno M.L. Rocha, Rita V. Gomes, Gon çalo J.L. Cunha, Gonçalo Mendes, Rui Morais, L. Campos, Inês Araújo, M. Cândida Fonseca Tags: Research Letter Source Type: research

Accuracy of Administrative Coding to Identify Reduced and Preserved Left Ventricular Ejection Fraction
Coding of systolic function in heart failure is important but the accuracy is uncertain. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 8, 2019 Category: Cardiology Authors: Paul A. Heidenreich, Sundar Natarajan, Hossein Bahrami Tags: Brief Report Source Type: research

Predictive Abilities of Machine Learning Techniques May Be Limited by Dataset Characteristics: Insights from the UNOS Database
Traditional statistical approaches to prediction of outcomes have drawbacks when applied to large clinical databases. It is hypothesized that machine learning methodologies might overcome these limitations by considering higher dimensional and nonlinear relationships among patient variables. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 6, 2019 Category: Cardiology Authors: P. Elliott Miller, Sumeet Pawar, Benjamin Vaccaro, Megan McCullough, Pooja Rao, Rohit Ghosh, Prashant Warier, Nihar R Desai, Tariq Ahmad Tags: Brief Report Source Type: research

Why would the effect of beet root juice on exercise capacity in HFrEF vary with etiology?
We read with interest the work of Coggan et al. published in the Journal of Cardiac Failure (2018; 24:65-73) in February of last year1 with accompanying editorial by Julio Chirinos (2018; 24:74-77)2. Coggan et al. reported that patients with heart failure due to reduced ejection fraction (HFrEF) had an increase in peak oxygen uptake (V ̇O2peak) and peak power output following ingestion of a concentrated beet root juice supplement in a randomized, double-blind, placebo-controlled, cross-over design. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 6, 2019 Category: Cardiology Authors: Catherine Notarius Source Type: research

Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time
In this issue of Journal of Cardiac Failure, Karlstedt and colleagues describe a study of 53 patients with ATTR cardiac amyloidosis who were treated with a regimen of doxycycline and ursodiol.1 The authors should be congratulated on reporting a relatively large single-institution experience, and their study represents an important addition to our current knowledge. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 3, 2019 Category: Cardiology Authors: Ronald Witteles Tags: Brief Report Source Type: research

Ischemic cardiomyopathy affects the thioredoxin system in the human myocardium
Oxidative stress due to reactive oxygen species (ROS) production is one key factor in the development of heart failure (HF). The present study investigated the thioredoxin (Trx) system, which plays a major role in antioxidant defense, in patients suffering from ischemic (ICM) or dilative cardiomyopathy (DCM). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 2, 2019 Category: Cardiology Authors: Stephan Neidhardt, Jens Garbade, Fabian Emrich, Kristin Klaeske, Michael A. Borger, Sven Lehmann, Khalil Jawad, Maja-Theresa Dieterlen Source Type: research

Relationship of Liver Stiffness with Congestion in Patients Presenting with Acute Decompensated Heart Failure
Congestion is the main driver of cardiac decompensation, a poor prognostic marker, and one of the main targets in the treatment in acute decompensated heart failure (ADHF)1. Among several pathophysiologic factors congestion is also thought to be one of the most important drivers for end-organ injury and failure in HF2, 3. Prolonged and chronic congestion can induce liver fibrosis or even cirrhosis with significant impairments in liver function, which are common in HF, have prognostic implications and a potential impact on treatment decisions4, 5. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 2, 2019 Category: Cardiology Authors: Anzhela Soloveva, Zhanna Kobalava, Marat Fudim, Andrew P. Ambrosy, Svetlana Villevalde, Munkhtsetseg Bayarsaikhan, Irina Garmash, Maksim Naumenko Source Type: research

Influence of Risk on Reduction of Readmission and Death by Disease Management Programs in Heart Failure
Heart failure (HF) is the leading cause of hospitalization and rehospitalization for adults aged>65 years.1,2 Despite improvement in outcomes due to development in evidence-based HF medication, post-discharge readmissions among HF patients continue to increase.2 Over the past decade, substantial attention has been focused on early readmission following an index admission of HF, especially since the inclusion of 30-day all-cause readmission or death as a major focus of quality improvement and payment reform. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 2, 2019 Category: Cardiology Authors: Quan L Huynh, Kristyn Whitmore, Kazuaki Negishi, Thomas H Marwick, ETHELRED investigators Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Source Type: research

Information for Authors
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Source Type: research

The Positives of Negative Data
This article includes multiple citations of a primary paper by the authors2 that was recently cited in an expression of concern by the New England Journal of Medicine. In addition, the review article in the JCF contains previously unpublished primary data including micrographs depicting proliferating cardiomyocytes. Similar micrographs are under investigation for image manipulation by both the NEJM and Brigham and Women's Hospital. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Authors: April Stempien-Otero Source Type: research

Expression of Concern
In the December 2002 issue of the Journal of Cardiac Failure, we published a review paper entitled “Myocyte proliferation and ventricular remodeling” by Leri, Kajstura and Anversa [1]. Based on (1) recent evidence of data and image manipulation [2], (2) the citation of a paper of questionable merit in the 2002 paper and (3) the inclusion of several previously unpublished images of uncertain a ccuracy in the same paper, we are publishing this Expression of Concern that materials presented in the 2002 paper may not be reliable. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Authors: Paul J. Hauptman Tags: Expression of Concern Source Type: research

Physiologic Adaptation or Cirrhotic Cardiomyopathy: It is Time for New Definitions!
Cardiovascular diseases, including heart failure, have become the leading cause of postoperative mortality in patients undergoing liver transplantation (LT).1 Consequently, liver transplant programs include a strict cardiac evaluation to identify and optimize cardiovascular diseases before listing a patient for LT. The identification of well-defined predictors of post-LT cardiovascular events would allow for optimization of the selection process and care around LT. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2019 Category: Cardiology Authors: Osama Altayar, Mauricio Lisker-Melman Tags: Brief Report Source Type: research

Elevated Heart Rate Following Heart Transplantation Is Associated with Increased Graft Vasculopathy and Mortality
The effect of elevated heart rate (HR) on outcomes following heart transplantation (HTx) has not been well established. The aim of this study was to assess predictors of elevated HR following HTx and its impact on outcomes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 24, 2019 Category: Cardiology Authors: Max Liebo, Joshua Newman, Anjali Joshi, Brian D Lowes, Yael Peled-Potashnik, Haseeb Ilias Basha, Ronald Zolty, John Y Um, Edwin McGee, Alain Heroux, Eugenia Raichlin Source Type: research

Effect on Long-Term Mortality of HLA-DR Matching in Heart Transplantation
Human leukocyte antigen (HLA) matching exerts a protective effect in organ transplantation, ensuring better graft function, fewer episodes of rejection, longer graft survival, and the possibility of lower immunosuppression.1 –3 However, the precise influence of HLA incompatibility in heart transplants remains to be determined, and prospective HLA matching is seldom achieved. We previously demonstrated that the odds of in-hospital mortality after heart transplantation is greater in the case of HLA-DR mismatch. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 22, 2019 Category: Cardiology Authors: Francesco Cacciatore, Cristiano Amarelli, Chiara Sabia, Irene Mattucci, Claudio Marra, Giampaolo Romano, Pasquale Abete, Ciro Maiello, Claudio Napoli Tags: Research Letter Source Type: research

Effect on long term mortality of Human leukocyte Antigen DR matching in heart transplantation
Human Leukocyte Antigen (HLA) matching exerts a protective effect in organ transplantation ensuring better graft function, fewer episodes of rejection, longer graft survival and the possibility of lower immunosuppression.1 –3 However, the precise influence of HLA incompatibility in heart transplants remains to be determined, and prospective HLA matching is seldom achieved. We previously demonstrated that the odds of in-hospital mortality after heart transplantation is greater in the case of DR-mismatch. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 22, 2019 Category: Cardiology Authors: Francesco Cacciatore, Cristiano Amarelli, Chiara Sabia, Irene Mattucci, Claudio Marra, Giampaolo Romano, Pasquale Abete, Ciro Maiello, Claudio Napoli Tags: Research Letter Source Type: research

Low T3 syndrome is associated with high mortality in hospitalized patients with heart failure
Thyroid hormone abnormalities affect the heart and cardiovascular system.[1,2] It has been recognized that overt hyperthyroidism,[3] subclinical hyperthyroidism,[3,4] and subclinical hypothyroidism [4-6] have an unfavorable prognostic impact in patients with heart failure (HF). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 22, 2019 Category: Cardiology Authors: Yu Sato, Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Yuki Kanno, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Yasuchika Takeishi Source Type: research

Clinical Experience With the Use of Doxycycline and Ursodeoxycholic Acid for the Treatment of Transthyretin Cardiac Amyloidosis
Transthyretin cardiac amyloidosis (ATTR CA) is characterized by extracellular myocardial deposition of amyloid fibrils derived from either wild-type or mutant forms of the transthyretin protein (TTR).1 –3 ATTR CA represents an important cause of progressive heart failure which is now increasingly recognized with improved modern diagnostic strategies.4 Previously, treatment options for ATTR CA were limited to supportive care, with the possibility of cardiac transplantation for a small number of e ligible patients with advanced heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 17, 2019 Category: Cardiology Authors: Erin Karlstedt, Victor Jimenez-Zepeda, Jonathan G. Howlett, James A. White, Nowell M. Fine Source Type: research

Clinical Experience Using Doxycycline and Ursodeoxycholic Acid for the Treatment of Transthyretin Cardiac Amyloidosis
Transthyretin cardiac amyloidosis (ATTR CA) is characterized by extracellular myocardial deposition of amyloid fibrils derived from either the wild-type or mutant forms of the transthyretin protein (TTR).1-3 ATTR CA represents an important cause of progressive heart failure which is now increasingly recognized with improved modern diagnostic strategies.4 Previously, treatment options for ATTR CA were limited to supportive care only, with the possibility of cardiac transplantation for a small number of eligible patients with advanced heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 17, 2019 Category: Cardiology Authors: Erin Karlstedt, Victor Jimenez-Zepeda, Jonathan G. Howlett, James A. White, Nowell M. Fine Source Type: research

The Neutrophil-Lymphocyte Ratio and Survival During Left Ventricular Assist Device Support
Systolic heart failure (HF) is a low-grade systemic inflammatory state. Inflammation has been implicated in the progression of HF and is associated with myocardial remodeling, hypertrophy and poorer HF outcomes.1 The ratio between peripheral neutrophils and lymphocytes can be altered by inflammation, resulting in an elevated neutrophil-lymphocyte ratio (NLR). The NLR has become established as an inexpensive and accessible non-specific  biomarker of low-grade systemic inflammation, showing prognostic utility in several cardiac settings including after acute coronary syndromes,2 post-coronary artery bypass grafting...
Source: Journal of Cardiac Failure - January 15, 2019 Category: Cardiology Authors: Sakthi Sundararajan, Michael S. Kiernan, Gregory S. Couper, Jenica N. Upshaw, David DeNofrio, Amanda R. Vest Tags: Clinical Investigation Source Type: research

Beta-Endorphin Elevation: Another Mechanism of Action of Sacubitril/Valsartan in Heart Failure?
We read with great interest the recent article entitled “A Novel Paradigm For Sacubitril/Valsartan: Beta-Endorphin Elevation As A Contributor To Exercise Tolerance Improvement In Rats With (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 9, 2019 Category: Cardiology Authors: Sercan Okutucu, Cengiz Sabanoglu, Ali Oto Tags: Letter to the Editor Source Type: research

Response to Letter to the Editor by Dr Kobayashi and Colleagues
To the Editor: (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 7, 2019 Category: Cardiology Authors: Wayne L. Miller, Marat Fudim Tags: Letter to the Editor Source Type: research

Increases in Serum Autoantibodies After Left Ventricular Assist Device Implantation
Left ventricular assist devices (LVADs) can serve as a bridge to transplant or destination therapy for patients with advanced heart failure. Implantation of LVADs is known to be associated with increases in anti-HLA antibodies, but less is known about how autoantibody levels change with the use of these devices. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 7, 2019 Category: Cardiology Authors: Liza Grosman-Rimon, Prabjit Ajrawat, Jocelyn Lioe, Laura C. Tumiati, Vivek Rao, Filio Billia, Andrzej Chruscinski Tags: Brief Report Source Type: research

Increases in Serum Autoantibodies Following Left Ventricular Assist Device Implantation
Left ventricular assist devices (LVADs) can serve as a bridge to transplant and/or destination therapy for patients with advanced heart failure. Implantation of LVADs is known to be associated with increases in anti-HLA antibodies, but less is known about how autoantibody levels change with these devices. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 7, 2019 Category: Cardiology Authors: Liza Grosman-Rimon, Prabjit Ajrawat, Jocelyn Lioe, Laura C. Tumiati, Vivek Rao, Filio Billia, Andrzej Chruscinski Tags: Brief Report Source Type: research

Changing heart failure coding practices and hospital risk-standardized mortality rates
As the most common reason for hospitalization among the elderly, admissions for acute heart failure (HF) are a frequent target for quality measurement and improvement activities. Large scale performance improvement initiatives such as the Centers for Medicare and Medicaid Services (CMS) Value Based Purchasing program use hospital HF mortality measures to determine hospital reimbursement rates.1,2 To identify patients with a hospitalization for HF, programs use International Classification of Diseases 9th or 10th Edition codes limited to the principal diagnosis position. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 7, 2019 Category: Cardiology Authors: Allan J. Walkey, Meng-Shiou Shieh, Penelope Pekow, Tara Lagu, Peter K. Lindenauer Source Type: research

Response to letter to the editor by Dr. Kobayashi and colleagues
We appreciate the clarification provided by Kobayashi and colleagues. Using the modified Duarte formula1 does not provide an absolute plasma volume assessment but rather an estimate and unlike the Kaplan-Hakim formula, the Duarte formula has the unit of dL/g. While the commonly used PV formulas do not accurately reflect the measured PV, a distinction of our analysis was to point out that while such estimates cannot be used to guide volume management therapy in the individual patient, there remains a prognostic value of the formula estimates2 –4 correlating with short and mid-term clinical outcomes in patients with he...
Source: Journal of Cardiac Failure - January 7, 2019 Category: Cardiology Authors: Wayne L. Miller, Marat Fudim Tags: Letter to the Editor Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2019 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2019 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2019 Category: Cardiology Source Type: research

Information for Authors
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2019 Category: Cardiology Source Type: research

Taking Some Time Out
Life without celebrations is a long road without inns. ― Democritus (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2019 Category: Cardiology Authors: Paul J. Hauptman Tags: Editorial Source Type: research

The Journal is dependent not only on its Editorial Board members but also on external consultants who generously provide their time to review submitted manuscripts. We express appreciation to all individuals who have served the Journal by providing reviews in the previous year of publication.
High volume reviewers (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2019 Category: Cardiology Tags: Acknowledgment of Reviewers Source Type: research

Comparison of Percutaneous and Surgical Right Ventricular Assist Device Support After Durable Left Ventricular Assist Device Insertion
Early right ventricular (RV) failure affects up to 30% –40% of patients undergoing left ventricular assist device (LVAD) insertion, and is associated with increased morbidity and mortality in this population.1–5 Multiple tools for identifying patients at risk of RV failure have been proposed, with varying degrees of accuracy.2–4,6 Although some pa tients are supported sufficiently with the use of medical therapy, others require RV mechanical support, traditionally with the use of surgically implanted devices. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 21, 2018 Category: Cardiology Authors: Ellie J. Coromilas, Koji Takeda, Masahiko Ando, Marisa Cevasco, Phillip Green, Dimitri Karmpaliotis, Ajay Kirtane, Veli K. Topkara, Melana Yuzefpolskaya, Hiroo Takayama, Yoshifumi Naka, Daniel Burkhoff, Paolo C. Colombo, A. Reshad Garan Tags: Clinical Investigation Source Type: research

The Prevalence of Cognitive Impairment Among Adults With Incident Heart Failure: The “Reasons for Geographic and Racial Differences in Stroke” (REGARDS) Study
Cognitive impairment (CI) is one of the most common comorbid conditions among adults with heart failure (HF)1,2 and is associated with poor quality of life3 and self-care4 and increased morbidity and mortality.5 –7 Although previous studies agree that CI is highly prevalent in HF, prevalence estimates vary widely, ranging from 25% to 80%.1,7,8 In addition, the underlying pathophysiology of CI and its trajectory in HF remain uncertain.1,7 (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 21, 2018 Category: Cardiology Authors: Madeline R. Sterling, Deanna Jannat-Khah, Joanna Bryan, Samprit Banerjee, Leslie A. McClure, Virginia G. Wadley, Frederick W. Unverzagt, Emily B. Levitan, Parag Goyal, Janey C. Peterson, Jennifer J. Manly, Deborah A. Levine, Monika M. Safford Tags: Brief Report Source Type: research

The Prevalence of Cognitive Impairment Among Adults with Incident Heart Failure: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Cognitive impairment (CI) is one of the most common comorbid conditions among adults with heart failure (HF)1, 2 and is associated with poor quality of life3 and self-care,4 and increased morbidity and mortality.5 –7 While prior studies agree that CI is highly prevalent in HF, prevalence estimates vary widely, ranging from 25-80%.1, 7, 8 Additionally, the underlying pathophysiology of CI and its trajectory in HF, remain uncertain.1, 7 (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 21, 2018 Category: Cardiology Authors: Madeline R. Sterling, Deanna Jannat-Khah, Joanna Bryan, Samprit Banerjee, Leslie A. McClure, Virginia G. Wadley, Frederick W. Unverzagt, Emily B. Levitan, Parag Goyal, Janey C. Peterson, Jennifer J. Manly, Deborah A. Levine, Monika M. Safford Tags: Brief Report Source Type: research

Comparison of Percutaneous and Surgical Right Ventricular Assist Device Support Following Durable Left Ventricular Assist Device Insertion
Early right ventricular (RV) failure affects up to 30-40% of patients undergoing left ventricular assist device (LVAD) insertion, and is associated with increased morbidity and mortality in this population.1-5 Multiple tools for identifying patients at risk of RV failure have been proposed with varying degrees of accuracy.2-4,6 While some patients are supported sufficiently with medical therapy, others require RV mechanical support, traditionally with surgically implanted devices. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 21, 2018 Category: Cardiology Authors: Ellie J Coromilas, Koji Takeda, Masahiko Ando, Marisa Cevasco, Phillip Green, Dimitri Karmpaliotis, Ajay Kirtane, Veli K Topkara, Melana Yuzefpolskaya, Hiroo Takayama, Yoshifumi Naka, Daniel Burkhoff, Paolo C. Colombo, A. Reshad Garan Tags: Clinical Investigation Source Type: research

The unit of Estimated Plasma Volume in Patients with Heart Failure using the Strauss-derived Duarte formula is not liter but dL/g
We read with great interest the report of Fudim and colleagues investigating the association between measurement and estimation of plasma volume in patients with heart failure (HF).1 There is growing evidence regarding the prognostic value of estimated plasma volume (ePVS) in patients with heart failure (HF)2 –4 although head-to-head comparisons between ePVS and actual PV measurements were currently lacking. The authors are to be highly commended for having performed such a comparison with actual plasma volume calculated from the isotopic method. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 13, 2018 Category: Cardiology Authors: Masatake Kobayashi, Olivier Huttin, Patrick Rossignol, Nicolas Girerd Tags: Letter to the Editor Source Type: research

Association of Endothelin-1 with Accelerated Cardiac Allograft Vasculopathy and Late Mortality Following Heart Transplantation
Fifty years after the first human heart transplant, cardiac allograft vasculopathy (CAV) remains the nemesis of recipient long-term survival (HT).1,2 CAV is a complex disease of the graft coronary arteries characterized by diffuse intimal hyperplasia and negative remodeling (i.e. vessel shrinkage due to increased medial tone and adventitial fibrosis), dual processes that together lead to accelerated luminal obstruction of the entire coronary tree.3,4 Despite advances over the past few decades to combat CAV, including the advent of statins and robust immunosuppressive agents, current international registry data demonstrate ...
Source: Journal of Cardiac Failure - December 10, 2018 Category: Cardiology Authors: Rushi V. Parikh, Kiran Khush, Vedant S. Pargaonkar, Helen Luikart, David Grimm, Michelle Yu, Kozo Akada, Yasuhiro Honda, Alan C. Yeung, Hannah Valantine, William F. Fearon Source Type: research

The Optimal Plasma Volume Status in Heart Failure in Relation to Clinical Outcome
Plasma volume expansion is a hallmark of the heart failure syndrome and contributes to the development of congestion (ie, an increase in filling pressures).1 Unrestrained chronic neurohormonal activation in heart failure induces a situation of plasma volume expansion.2 If the subsequent plasma volume expansion overwhelms the decreasing venous capacitance as a result of increased neurohumoral activation, an increase in filling pressures ensues with progressive deterioration to acute heart failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 4, 2018 Category: Cardiology Authors: Pieter Martens, Petra Nijst, Matthias Dupont, Wilfried Mullens Tags: Clinical Investigation Source Type: research