Identifying and Addressing Gaps in the Use of Cardiac Resynchronization Therapy
Cardiac resynchronization therapy (CRT) reduces the risk of mortality and heart failure events in select patients with left ventricular systolic dysfunction.1 –4 Prior studies have suggested underuse of CRT among eligible patients.5 Within a large regional health care system, we sought to identify and address potential underuse of CRT. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 26, 2020 Category: Cardiology Authors: Steven M. Bradley, Ambareesh Bagpai, Chelsey Thomas, Shaina Witt, Pam Rush, Craig E. Strauss, Peter M. Eckman Tags: Research Letter Source Type: research

Intestinal flora dysbiosis aggravates cognitive dysfunction associated with neuroinflammation in heart failure
Cognitive impairment is a common central nervous system complication after heart failure (HF), with an incidence as high as 25-75%.1 Cognitive dysfunction seriously affects patient quality of life and imposes a heavy economic burden on society and families. Many factors are involved in the mechanisms underlying cognitive dysfunction after HF. These factors include low cerebral perfusion, abnormal hormone secretion and the immune/inflammatory response.2,3 Several clinical studies have explored the above damage-inducing mechanisms, but no therapeutic effects have been described. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 24, 2020 Category: Cardiology Authors: Wei Yu, Dapeng Gao, Wen Jin, Zijian Wang, Yan Li, Xiaowei Peng, Yushuang Cong, Chenglong Li, Ayang Zhao, Shuai Liu, Sihua Qi Source Type: research

2020 ACC/HFSA/ISHLT Lifelong Learning Statement for Advanced Heart Failure and Transplant Cardiology Specialists
Since the publication of its first Core Cardiovascular Training Statement (COCATS) in 1995,1 the American College of Cardiology (ACC) has defined the knowledge, experiences, skills, and behaviors expected of clinical cardiologists. Subsequent revisions have moved toward competency-based training based on the 6-domain competency structure promulgated by the Accreditation Council for Graduate Medical Education (ACGME) and the American Board of Medical Specialties and endorsed by the American Board of Internal Medicine (ABIM). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 17, 2020 Category: Cardiology Authors: Writing Committee Members, Clyde W. Yancy, Mark H. Drazner, Samuel Tristram Coffin, William Cornwell, Shashank Desai, John P. Erwin, Mahazarin Ginwalla, Karol S. Harshaw-Ellis, Tamara Horwich, Michelle Kittleson, Anuradha Lala, Sabra C. Lewsey, Joseph E. Tags: LIFELONG LEARNING STATEMENT Source Type: research

Effects of Elamipretide on Left Ventricular Function in Patients with Heart Failure with Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial
The objective of this study was to evaluate the effects of multiple subcutaneous doses of elamipretide on left ventricular end systolic volume (LVESV) assessed by cardiac magnetic resonance imaging (MRI). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 14, 2020 Category: Cardiology Authors: Javed Butler, Muhammad Shahzeb Khan, Stefan D. Anker, Gregg C. Fonarow, Raymond J. Kim, Savina Nodari, Christopher M. O'Connor, Burkert Pieske, Elisabeth Pieske-Kraigher, Hani N. Sabbah, Michele Senni, Adriaan A. Voors, James E. Udelson, Jim Carr, Mihai G Source Type: research

Body Fat and Fitness for VAD Therapy
By 2030, 1 in 2 adults in the United States will be obese, defined as a body mass index (BMI) ≥30kg/m2, and nearly 1 in 4 will suffer from extreme obesity with a BMI ≥35 kg/m2.1 Obesity can impair left ventricular structure and contractile function and is an independent risk factor for the development of heart failure (HF). Although there is a modest protective benefit to being overweigh t once HF is established—the famous “obesity paradox—an increasing number of obese patients with advanced systolic HF are undergoing evaluation for heart transplantation and durable mechanical circulatory support (M...
Source: Journal of Cardiac Failure - February 6, 2020 Category: Cardiology Authors: Garrick C. Stewart Tags: Editorial Source Type: research

Longitudinal Trajectories of Hemodynamics Following Left Ventricular Assist Device Implantation
Continuous-flow left ventricular assist devices (LVADs) have become the mainstay therapy for advanced heart failure (HF) patients, both as a bridge to transplantation and as destination therapy.1 LVADs improve clinical outcomes in HF patients by improving hemodynamics.2, 3 However, some patients develop HF symptoms following LVAD implantation, mainly due to right ventricular failure (RVF), a significant early postoperative complication following LVAD implantation.4, 5 Late-onset RVF can also occur during long-term LVAD support and is associated with increased morbidity and mortality. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 3, 2020 Category: Cardiology Authors: Takeo Fujino, Aline Sayer, Daisuke Nitta, Teruhiko Imamura, Nikhil Narang, Ann Nguyen, Daniel Rodgers, Jayant Raikhelkar, Bryan Smith, Gene Kim, Colleen LaBuhn, Valluvan Jeevanandam, Daniel Burkhoff, Gabriel Sayer, Nir Uriel Source Type: research

A Time for Focus
One of the advantages of serving as the editors of a heart failure journal pertains to the detection of trends. By trends, we do not mean to suggest volume of submissions, Impact Factor or turnaround times, but rather subject matter. In the current issue of the Journal, we present a series of organically —grown mini-focus collections of papers on topics related to three areas: obesity and heart failure; invasive, non-invasive and physical assessment of fluid status; and unconventional treatment paradigms. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2020 Category: Cardiology Authors: Paul J. Hauptman, Michael W. Rich Source Type: research

Pregnancy and Heart Failure – A Call for Papers
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2020 Category: Cardiology Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2020 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2020 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2020 Category: Cardiology Source Type: research

Information for Authors
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - February 1, 2020 Category: Cardiology Source Type: research

Echocardiographic evaluation of left ventricular filling pressure in patients with heart failure with preserved ejection fraction: usefulness of inferior vena cava measurements and 2016 EACVI/ASE recommendations
Transthoracic echocardiography (TTE) is a key examination for the evaluation of LVFP (1). The non-invasive diagnosis of an abnormal increase in LVFP by TTE remains difficult to interpret in a significant proportion of patients (2-4). However, the TTE-based estimation of LVFP is important for several reasons. It is a key element for the diagnosis, treatment guidance, and prognostic evaluation of HF (5). Although heart catheterization is the reference method to measure LVFP, this invasive procedure cannot be routinely performed, with TTE therefore remaining the first-line method (1). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 30, 2020 Category: Cardiology Authors: Emmanuelle Berthelot, Patrick Jourdain, Minh Tam Bailly, Amir Bouchachi, Barnabas Gellen, Alexandra Rouquette, Thibaud Damy, Philippe Herv é, Denis Chemla, Patrick Assayag Source Type: research

Effect of Loop Diuretics on the Fractional Excretion of Urea in decompensated Heart Failure
Fractional excretion of urea (FEUrea) is often used to understand the etiology of acute kidney injury (AKI) in patients receiving diuretics. While FEUrea demonstrates diagnostic superiority over fractional excretion of sodium (FENa), clinicians often assume FEUrea is not affected by diuretics. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 30, 2020 Category: Cardiology Authors: Zachary L. Cox, Krishna Sury, Veena S. Rao, Juan B. Ivey-Miranda, Matthew Griffin, Devin Mahoney, Nicole Gomez, James H. Fleming, Lesley A. Inker, Steven G. Coca, Jeff Turner, F. Perry Wilson, Jeffrey M. Testani Source Type: research

Impact of a formal advance care planning program on end-of-life care for patients with heart failure: Results from a randomized controlled trial
Despite advent of new therapies, heart failure (HF) remains a leading cause of death worldwide.1 Quality end of life (EOL) care for HF patients involves providing care consistent with their preferences. Advance care planning (ACP) discussions with HF patients can facilitate informed decision making, reduce decisional uncertainty and enable care consistent with preferences. Despite the potential, evidence on its effectiveness is limited to oncology patients2 and those at risk of imminent mortality such as elderly hospitalized or in nursing homes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 25, 2020 Category: Cardiology Authors: Chetna Malhotra, David Sim, Fazlur Rehman Jaufeerally, Meibo Hu, Nivedita Nadkarni, Clarice Shu Hwa Ng, Genevieve Wong, Boon Cheng Tan, Jing Fen Lim, Claire Ya-Ting Chuang, Eric A. Finkelstein Source Type: research

The Role of Cardiac Rehabilitation in Reducing Major Adverse Cardiac Events in Heart Transplant Patients
Cardiac rehabilitation (CR) is a recommended treatment strategy for multiple populations to elicit well-established improvements in functional capacity, quality of life, and long-term outcomes.1 –6 Risk reduction has been shown in both all-cause and cardiovascular mortality with CR participation following percutaneous coronary intervention (PCI), myocardial infarction (MI), coronary artery bypass graft (CABG) surgery, and ventricular assist device implantation.1,7–10 More recently, long -term major adverse cardiac events (MACE) have also been investigated in these populations as a method of identifying high-ris...
Source: Journal of Cardiac Failure - January 22, 2020 Category: Cardiology Authors: Katelyn E. Uithoven, Joshua R. Smith, Jose R. Medina-Inojosa, Ray W. Squires, Thomas P. Olson Source Type: research

Low pulmonary artery pulsatility index is associated with adverse outcomes in ambulatory patients with advanced heart failure
The prevalence of heart failure is increasing worldwide and up to 10% of patients progress to advanced heart failure, becoming refractory to medical therapy. 1-4 Patients with advanced heart failure frequently develop symptoms and signs of elevated right-sided filling pressures, due to congestion and right ventricular dysfunction. The syndrome of right heart failure is associated with reduced exercise tolerance, impaired quality of life and increased mortality. 5-7 Recent improvements in medical therapy have reduced rates of sudden death and more patients may therefore survive to develop progressive right heart failure. (S...
Source: Journal of Cardiac Failure - January 22, 2020 Category: Cardiology Authors: Silvia Cesini, Sai Bhagra, Stephen J Pettit Source Type: research

HVAD Flow Waveform Estimates Left Ventricular Filling Pressure
HVAD left ventricular assist device (LVAD) flow waveforms provides graphical real-time information linking device performance with invasive hemodynamics. Previous studies have demonstrated a good correlation between the slopes of the ventricular filling phase (VFPS) and directly measured pulmonary capillary wedge pressure (PCWP). We aimed to validate the utility of VFPS to estimate PCWP and predict clinical outcomes. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 22, 2020 Category: Cardiology Authors: Teruhiko Imamura, Nikhil Narang, Daniel Rodgers, Daisuke Nitta, Jonathan Grinstein, Takeo Fujino, Gene Kim, Ann Nguyen, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel Source Type: research

Timing and trends of right atrial pressure and risk of right heart failure after left ventricular assist device implantation
Elevated right atrial pressure (RAP) is associated with poor outcomes after LVAD implantation. However, the optimal time for RAP measurement and the importance of resolution of right heart congestion prior to LVAD implantation remain unclear. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 22, 2020 Category: Cardiology Authors: Gaurav Gulati, Nilay Sutaria, Amanda R Vest, David D DeNofrio, Masashi Kawabori, Gregory Couper, Michael Kiernan Source Type: research

Impact of continuous flow left ventricular assist device therapy on chronic kidney disease: a longitudinal multicenter study
Left ventricular assist devices (LVADs) have become an accepted treatment modality for end-stage heart failure (HF) patients.(1) End-stage HF patients often suffer from end-organ dysfunction, including chronic kidney disease (CKD), which is often attributed to the cardio-renal syndrome.(2) Cardio-renal syndrome type 2, renal dysfunction caused by a number of factors including high central venous pressures and insufficient cardiac output, frequently hampers the quality of life of these patients.(3) They are at risks for developing end-stage renal disease and have higher rates of mortality following LVAD implantation.(4 &nda...
Source: Journal of Cardiac Failure - January 22, 2020 Category: Cardiology Authors: Yunus C. Yalcin, Rahatullah Muslem, Kevin M. Veen, OsamaI. Soliman, Dennis A. Hesselink, Alina A. Constantinescu, Jasper J. Brugts, Olivier C. Manintveld, Marat Fudim, Stuart D Russell, Brett Tomashitis, Brian A. Houston, Steven Hsu, Ryan J. Tedford, AdJ. Source Type: research

Neighborhood Fences and Heart Failure Inequities
An illustration of three boys attempting to sneak a peek at a baseball game while standing behind a solid, wooden fence is sometimes used to contrast the concepts of equality and equity. The boys range in height from short to tall. Each boy stands on a crate of equal size, presumably to gain the lift needed to see over the fence. Although this arrangement helps the taller boys, the fence continues to obstruct the shortest boy's view of the game. When the crates are reorganized so that the tallest boy stands on the ground and the shortest boy stands atop two stacked crates, the three boys can view the game from similar pers...
Source: Journal of Cardiac Failure - January 21, 2020 Category: Cardiology Authors: Kimberly R. Enard Tags: Brief Report Source Type: research

The Other Substance Abuse Epidemic: Methamphetamines and Heart Failure
Methamphetamine is a central nervous system stimulant initially synthesized from ephedrine in 1893 by the Japanese chemist Nagai Nagayoshi. It was utilized in World War II by Allied and Axis forces for their effects on performance enhancement.1 Because of rising abuse, methamphetamines became a schedule II controlled substance in the United States in 1971.2 Over the past 50 years, there has been a gradual increase in the incidence of methamphetamine abuse followed by a recent rapid rise. Although methamphetamine abuse was dramatized in the popular TV series Breaking Bad, the epidemic has largely been overshadowed by overdo...
Source: Journal of Cardiac Failure - January 17, 2020 Category: Cardiology Authors: Kenneth D. Varian, Eiran Z. Gorodeski Tags: Brief Report Source Type: research

Sex Differences in Exercise Capacity and Quality of Life in Heart Failure with Preserved Ejection Fraction: A Secondary Analysis of the RELAX and NEAT-HFpEF Trials
Few studies have compared clinical characteristics, echocardiographic parameters, exercise capacity, and quality of life between women and men with heart failure with preserved ejection fraction (HFpEF). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 13, 2020 Category: Cardiology Authors: Michael C. Honigberg, Emily S. Lau, Aaron D. Jones, Adrian Coles, Margaret M. Redfield, Gregory D. Lewis, Michael M. Givertz Tags: Brief Report Source Type: research

Zinc Deficiency and Heart Failure: A Systematic Review of the Current Literature
The human heart requires energy from micro and macro nutrients both to regenerate proteins and cells, and to support cyclic contractions.1 Heart failure (HF) is a systemic illness associated with neuro-hormonal activation leading to elevated levels of inflammatory markers and oxidative stress. Normally, micronutrients are only required in small amounts for antioxidant activities. However, in the HF state, there is increased generation of reactive oxygen and nitrogen species. As such, antioxidant enzymes – the generation of which relies on the availability of micronutrients such as zinc – are upregulated in stre...
Source: Journal of Cardiac Failure - January 11, 2020 Category: Cardiology Authors: Hannah Rosenblum, Jeffrey D. Wessler, Aakriti Gupta, Mathew S. Maurer, Behnood Bikdeli Tags: Review Article Source Type: research

Deep Y-Descent in Right Atrial Waveforms following Left Ventricular Assist Device Implantation
Characterization of right heart catheterization (RHC) waveforms provides diagnostic and clinical information in heart failure patients. We aimed to investigate the implication of RHC waveforms, specifically the y-descent, in patients with left ventricular assist device (LVAD). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 11, 2020 Category: Cardiology Authors: Teruhiko Imamura, Daisuke Nitta, Takeo Fujino, Bryan Smith, Sara Kalantari, Ann Nguyen, Nikhil Narang, Luise Holzhauser, Daniel Rodgers, Tae Song, Takeyoshi Ota, Valluvan Jeevanandam, Gene Kim, Gabriel Sayer, Nir Uriel Source Type: research

Beta-Blockers for Primary Therapy of Heart Failure With Preserved Ejection Fraction: An Idea Whose Time has Gone?
The beneficial effects of beta-blockers (BB) in heart failure (HF) with reduced ejection fraction (HFrEF), including large ( ∼60%) reductions in mortality even on top of other mortality-reducing agents, are well established. However, there is uncertainty regarding the potential benefits and risks of BB for patients with HF with preserved ejection fraction (HFpEF), with a considerable amount of data suggesting lack of be nefit or even worsening. In this issue of the Journal, Nambiar et al. provide additional valuable data regarding this important question. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 11, 2020 Category: Cardiology Authors: Bharathi Upadhya, DalaneW Kitzman Source Type: research

Prognostic significance of an early echocardiographic evaluation of right ventricular dimension and function in acute heart failure.
The prognostic impact of right ventricular (RV) dysfunction and of pulmonary hypertension (PH) in patients affected by chronic heart failure (CHF) has been well described by several invasive and non-invasive diagnostic tools [1 –7]. More recently, it has been demonstrated that taking into account the coupling between the afterload and the function of the right ventricle may prove more useful than considering this information separately. The tricuspid annular plane systolic excursion (TAPSE)/ systolic pulmonary artery pre ssure (PASP), a surrogate marker of RV-vascular coupling have already proven to be effective indi...
Source: Journal of Cardiac Failure - January 10, 2020 Category: Cardiology Authors: Alberto Palazzuoli, Gaetano Ruocco, Isabella Evangelista, Oreste De Vivo, Ranuccio Nuti, Stefano Ghio Source Type: research

Renal Dysfunction in Heart Failure with Preserved Ejection Fraction: Insights from the RELAX Trial
Patients with heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) represent a high-risk phenotype. The Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction (RELAX) trial enrolled a high proportion of CKD participants, allowing investigation into differences in HFpEF by CKD status. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 10, 2020 Category: Cardiology Authors: Ravi B. Patel, Rupal Mehta, Margaret M. Redfield, Barry A. Borlaug, Adrian F. Hernandez, Sanjiv J. Shah, Ruth F. Dubin Tags: Original Investigation Source Type: research

The Association Between Secondhand Smoke Exposure and Survival for Patients with Heart Failure
The effect of secondhand tobacco smoke (SHS) exposure on patients with heart failure (HF) is uncertain. We investigated the association of mortality with SHS exposure for patients with HF. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 8, 2020 Category: Cardiology Authors: Mitchell A. Psotka, Joshua Rushakoff, Stanton A. Glantz, Teresa De Marco, Kirsten E. Fleischmann Source Type: research

Read, Cite, Submit and Repeat!
With this issue, we begin our second 5-year term at the editorial helm and we are looking forward to continued growth. We believe that the future is bright as the Journal enters its 26th year of publication. Key metrics have improved. The contributions of the associate editors and statistical consultants are deeply appreciated. Their service to the JCF and by extension the HFSA are truly the keys to this growth and to securing a strong outlook for the future. They volunteer their time to review papers, obtain reviews, and participate in innumerable phone calls and email exchanges. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2020 Category: Cardiology Authors: Paul J. Hauptman, Michael W. Rich Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2020 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2020 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2020 Category: Cardiology Source Type: research

Information for Authors
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2020 Category: Cardiology Source Type: research

Acknowledgment of Reviewers 2019
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2020 Category: Cardiology Source Type: research

Baseline Right Ventricular Dysfunction Predicts Worse Outcomes in Patients Undergoing Cardiac Resynchronization Therapy (CRT) Implantation
Cardiac resynchronization therapy (CRT) has been shown to improve survival in patients with systolic heart failure, wide QRS duration, and left-bundle-branch-block (LBBB). However, CRT outcomes stratified by right ventricular (RV) function at implant have not been well studied. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 24, 2019 Category: Cardiology Authors: Divyang Patel, Kevin Trulock, Anirudh Kumar, Erich Kiehl, Saleem Toro, Laurie Anne Moennich, Eiran Gorodeski, Ayman Hussein, Daniel Cantillon, Khaldoun G. Tarakji, Mark Niebauer, Oussama Wazni, Niraj Varma, Bruce Wilkoff, John Rickard Source Type: research

Are obese patients with heart failure very different from non-obese patients?
Obesity or overweight status has become increasingly prevalent and when defined by body mass index (BMI) ≥30 kg/m2, 39.6% of all adults in the United States qualify as obese1. This is an urgent issue to address, as obesity clearly has many negative effects on patients’ health and the healthcare economy, including, in the cardiovascular system, hypertension, left ventricular hypertrophy, and sleep a pnea. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 24, 2019 Category: Cardiology Authors: Yuya Matsue Tags: Brief Report Source Type: research

Beneficial effects of listening to classical music in patients with heart failure: a randomized controlled trial
Heart failure (HF) syndrome is considered an “epidemic” whose prevalence, approximately 1-2% of the adult population in the developed countries, is expected to raise in the next years due to population ageing.1,2 A multidisciplinary HF team (physician, nurse, physiotherapist, psychologist, counsellor, and pharmacist) probably is the corner stone for a successful and comprehensive delivery of care. Despite the improvement of the medical treatments over the last decades, the outcome of patients with HF still remains unsatisfactory due to comorbidities. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 23, 2019 Category: Cardiology Authors: Francesco Burrai, Giuseppe D. Sanna, Eleonora Moccia, Francesco Morlando, Eugenio R. Cosentino, Virna Bui, Valentina Micheluzzi, Claudio Borghi, Guido Parodi Source Type: research

Biomarker Profile of Left Atrial Myopathy in Heart Failure with Preserved Ejection Fraction: Insights from the RELAX Trial
While left atrial (LA) mechanical dysfunction in heart failure with preserved ejection fraction (HFpEF) is associated with poor clinical outcomes, the influence of LA myopathy on temporal changes in cardiovascular biomarkers is unclear. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 17, 2019 Category: Cardiology Authors: Ravi B. Patel, Fawaz Alenezi, Jie-Lena Sun, Brooke Alhanti, Muthiah Vaduganathan, Jae K. Oh, Margaret M. Redfield, Javed Butler, Adrian F. Hernandez, Eric J. Velazquez, Sanjiv J. Shah Tags: Brief Report Source Type: research

Bioelectrical impedance analysis: Can it help in the assessment of congestion?
Estimation of volume status is an essential component in the management of patients with heart failure (HF) as it guides therapeutic decision making including medication adjustment (e.g., diuretics or beta-blockers) and timing of hospitalization for acute decompensated heart failure (ADHF). The physical examination remains central in the assessment of volume status in patients with HF.1 However, due to variable levels of confidence and accuracy in physical examination skills, there remain opportunities for novel strategies for this purpose. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 13, 2019 Category: Cardiology Authors: Jennifer T. Thibodeau, Mark H. Drazner Tags: Editorial Comment Source Type: research

Impact of Socioeconomic Factors on Patient Desire for Early LVAD Therapy Prior to Inotrope Dependence
Heart failure (HF) is a leading cause of increased cardiovascular morbidity and mortality. Poor health-related quality of life (HRQOL) and high rates of hospitalization impose significant burdens on both patients and society.1 Left ventricular assist devices (LVADs) improve survival, functional capacity and HRQOL in patients with end-stage systolic HF.2,3 (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 3, 2019 Category: Cardiology Authors: Inna Tchoukina, Keyur B. Shah, Jennifer T. Thibodeau, Jerry D. Estep, Anuradha Lala, David E. Lanfear, Nisha A. Gilotra, Salpy V. Pamboukian, Douglas A. Horstmanshof, Dennis M. McNamara, Donald C. Haas, Ulrich P. Jorde, Rhondalyn C. McLean, Thomas M. Casc Source Type: research

Stabilization of cardiac function with diflunisal in transthyretin (ATTR) cardiac amyloidosis
Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is an underappreciated cause of heart failure that results from misfolded TTR (prealbumin) protein. Diflunisal is an approved non-steroidal anti-inflammatory drug (NSAID) that stabilizes TTR, with limited data available regarding effects on cardiac structure and function. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 2, 2019 Category: Cardiology Authors: Graham Lohrmann, Alexandra Pipilas, Roberta Mussinelli, Deepa M. Gopal, John L. Berk, Lawreen H. Connors, Nirupama Vellanki, Jennifer Hellawell, Omar K. Siddiqi, Jonathan Fox, Mathew S. Maurer, Frederick L. Ruberg Source Type: research

Endoscopic Algorithm for Management of Gastrointestinal Bleeding in Patients With Continuous Flow LVADs: A Prospective Validation Study
Continuous flow-left ventricular assist device (CF-LVAD) technology has reduced mortality and improved the quality of life in patients with advanced heart failure (HF) refractory to medical therapy.1,2 Despite a significant reduction in adverse events with the latest generation of CF-LVADs, gastrointestinal bleeding (GIB) continues to be the most common complication and a significant source of morbidity. GIB accounts for high rates of hospital readmissions, with a reported incidence ranging from 17.6% to 61%. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Authors: Jordan E. Axelrad, Adam S. Faye, Alberto Pinsino, Anusorn Thanataveerat, Barbara Cagliostro, Marie Finelle T. Pineda, Katherine Ross, Rosie T. Te-Frey, Lisa Effner, Arthur R. Garan, Veli K. Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Ivonne Rami Source Type: research

Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Source Type: research

Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Source Type: research

Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Source Type: research

Information for Authors
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Source Type: research

PARAGON-HF - considerations for potential use of sacubitril-valsartan in real-world heart failure with mildly reduced ejection fraction
Recently, the results of the much anticipated Prospective Comparison of ARNI [angiotensin receptor –neprilysin inhibitor] with ARB [angiotensin-receptor blockers] Global Outcomes in HF with Preserved Ejection Fraction (PARAGON-HF) trial were published,1 showing that in patients with HFpEF (symptomatic HF, left ventricular EF ≥45%, structural heart disease, and elevated natriuretic peptides), sacubitril/valsartan compared to valsartan did not significantly improve the primary outcome of cardiovascular death or total HF hospitalizations (rate ratio 0.87; 95% confidence interval 0.75-1.01; p=0.06). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Authors: Lars H. Lund, Gianluigi Savarese Tags: Editorial Comment Source Type: research

Endoscopic Algorithm for Management of Gastrointestinal Bleeding in Patients with CF-LVADs: A Prospective Validation Study
Continuous flow-left ventricular assist device (CF-LVAD) technology has reduced mortality and improved the quality of life in patients with advanced heart failure (HF) refractory to medical therapy.1,2 Despite a significant reduction in adverse events with the latest generation of CF-LVADs, gastrointestinal bleeding (GIB) continues to be the most common complication and a significant source of morbidity. GIB accounts for high rates of hospital readmissions, with a reported incidence ranging from 17.6% to 61%. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Authors: Jordan E. Axelrad, Adam S. Faye, Alberto Pinsino, Anusorn Thanataveerat, Barbara Cagliostro, Marie Finelle T. Pineda, Katherine Ross, Rosie T. Te-Frey, Lisa Effner, Arthur R. Garan, Veli K. Topkara, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Ivonne Rami Source Type: research

Increased Red Cell Volume is a Relevant Contributing Factor to an Expanded Blood Volume in Compensated Systolic Chronic Heart Failure
In patients with chronic heart failure (CHF), volume overload is usually described as an expansion of plasma volume (PV). Additional red cell volume (RCV) expansion is less recognized. So far, little is known about quantitative differences in blood volume (BV) status and its different components in stable CHF patients compared to healthy controls. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - November 29, 2019 Category: Cardiology Authors: Christoph Ahlgrim, Philipp Birkner, Florian Seiler, Nina Wrobel, Sebastian Grundmann, Christoph Bode, Torben Pottgiesser Tags: Original Research Source Type: research