The Veterans Affairs ’ Dashboard Confessional: Vindication of the VA HF Dashboard
Recent reports on heart failure (HF) epidemiology and outcomes highlight that approximately 6.7 million Americans have HF. The lifetime risk of HF for adults in the United States is 24%, with increasing incidence and burden of HF risk factors, such as hypertension, obesity, and health inequities.[1] HF is associated with substantial economic burden, and health care related expenditure for the disease is increasing at a more rapid pace compared to other chronic conditions such as type 2 diabetes mellitus and cancer. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 10, 2024 Category: Cardiology Authors: Melissa Lyle, Mark N. Belkin Tags: Editorial Comment Source Type: research
A Reason to be Positive: Early Cardiac Allograft Vasculopathy and Acute Rejection in Recipients of HCV+ Donor Hearts
The increasing transplantation of hepatitis C virus (HCV) nucleic acid test (NAT) positive hearts in the contemporary era of direct-acting antiviral (DAA) therapy has been a critical, practical approach to expanding the donor pool for life-saving heart transplantation (1). While short term graft and patient survival has been established to be non-inferior to that of recipients of HCV NAT- organs, historical data had suggested an increased risk of cardiac allograft vasculopathy (CAV) among recipients of organs from HCV seropositive donors (2-4). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 10, 2024 Category: Cardiology Authors: Laura DiChiacchio, Andrew R Higgins Tags: Editorial Comment Source Type: research
Cardiac Troponin and Treatment Effects of Omecamtiv Mecarbil: Results from the GALACTIC-HF study
We examined the relationship between baseline troponin, change in troponin over time, and the treatment effect of omecamtiv mecarbil in patients enrolled in the Global Approach to Lowering Adverse Cardiac Outcomes through Improving Contractility in Heart Failure (GALACTIC-HF) trial (NCT02929329). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 10, 2024 Category: Cardiology Authors: G. Michael Felker, Scott D. Solomon, Marco Metra, John J.V. McMurray, Rafael Diaz, Brian Claggett, David E. Lanfear, Hans Vandekerckhove, Tor Biering-S ørensen, Renato D. Lopes, Alexandra Arias-Mendoza, Shin-ichi Momomura, Ramon Corbalan, Felix J.A. Rami Source Type: research
Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure with Preserved Ejection Fraction: Rationale, Design, and Lead-in Phase Results of the REBALANCE-HF Trial
Splanchnic vasoconstriction augments transfer of blood volume from the abdomen into the thorax, which may increase filling pressures and hemodynamic congestion in patients with noncompliant hearts. Therapeutic interruption of splanchnic nerve activity holds promise to reduce hemodynamic congestion in patients with heart failure with preserved ejection fraction (HFpEF). Here we describe (1) the rationale and design of the first sham-controlled randomized clinical trial (RCT) of splanchnic nerve ablation for HFpEF; and (2) the 12-month results of the lead-in (open-label) trial participants. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 9, 2024 Category: Cardiology Authors: Marat Fudim, Sheldon Litwin, Barry A. Borlaug, Rajeev C. Mohan, Matthew J. Price, Peter Fail, Teona Zirakashvili, Tamaz Shaburishvili, Parag Goyal, Scott L. Hummel, Ravi B. Patel, Vivek Y. Reddy, Daniel Burkhoff, Manesh R. Patel, Sami I. Somo, Sanjiv J. S Source Type: research
Heart Failure in Latin American Women: A Call for Action
Latin America (LATAM), defined as the region of the Americas where Romance-Latin-derived languages such as Spanish, Portuguese, and French are spoken, is comprised of 33 countries stretching from Mexico, Central America, and the Caribbean to Chile, the farthest South American territory. Encompassing 8.3%of the world's population (more than 670 million inhabitants, median age 31 years), 335 million women live in the various nations of this subcontinent, most of which are categorized as Low-and-Middle-Income1. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 8, 2024 Category: Cardiology Authors: Cesar J Herrera, Clara Saldarriaga, Edisson Feliz, Fernando Bacal, Pamela Pi ña, Alexandra Arias-Mendoza Tags: Perspectives Source Type: research
Characterization and Prognostic Implications of Respirophasic Variation in Invasive Hemodynamic Measurements at Rest and with Exercise
Pulmonary capillary wedge pressure (PCWP) is a key measure of left heart congestion used to establish or rule out the diagnosis of heart failure (HF). Diagnostic algorithms for HF with preserved ejection fraction (HFpEF) include or are validated based on rest and exercise PCWP measurements.1 However, previous studies have reached conflicting conclusions about whether PCWP measurements should be assessed at end-expiration (PCWPend-exp) or as a global mean across respiratory cycles (PCWPmean).2-4 In clinical practice heterogeneity in reporting mean vs. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 4, 2024 Category: Cardiology Authors: Joseph Campain, Ilya Giverts, Mark W Schoenicke, John Sbarbaro, Catharine Griskowitz, Alexandra Minasian, Cheshta Prasad, Andrew Lewis, Ravi V Shah, Raj Malhotra, Gregory D Lewis Tags: Brief Report Source Type: research
Corrigendum to ‘The International Society for Heart and Lung Transplantation/Heart Failure Society of America Guideline on Acute Mechanical Circulatory Support’
Affiliations (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Source Type: research
Proteomic Associations Of N-terminal-pro Hormone Bnp In Heart Failure With Preserved Ejection Fraction In Two Cohorts
N-terminal-pro natriuretic peptide (NT-proBNP) levels are variably elevated in heart failure with preserved ejection fraction (HFpEF), even among patients with increased left ventricular filling pressures. NT-proBNP levels are prognostic in HFpEF, and NT-proBNP levels have been used as an inclusion criterion for several recent landmark randomized clinical trials but the underlying biologic differences between HFpEF patients with high and low NT-proBNP levels are not fully understood. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Joe David Azzo, Marie-Joe Dib, Lei Zhao, Zhaoqing Wang, Christina Ebert, Oday Salman, Sushrima Gan, Payman Zamani, Jordana (Jordy) Cohen, Vanessa van Empel, Mark Richards, Robert Doughty, Ali Javaheri, Peter Schafer, Dietmar Seiffert, Francisco Ramirez-Va Tags: JNC-001 Source Type: research
Isovolumic Contraction Velocity In Heart Failure With Reduced Ejection Fraction And Effect Of Sacubitril/valsartan: The PROVE-HF Study
The load dependent left ventricular ejection fraction (LVEF) has been the cornerstone of systolic function assessment, yet its inherent limitations highlight the need for alternative prognostic measures of myocardial remodeling. We assessed the value of tissue-Doppler derived mitral annular isovolumic contraction velocity (ICV), a load independent measure of systolic function, in prediction of structural and functional cardiac changes after starting sacubitril/valsartan (sac/val) therapy in patients with heart failure with reduced ejection fraction (HFrEF). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Alaa M. Omar, Sean Murphy, Michael Felker, Ileana Pi ña, Javed Butler, Yuxi Liu, Reza Mohebi, Jonathan Ward, Kristin Williamson, Scott D. Solomon, James Januzzi, Johannita Contreras Tags: JNC-002 Source Type: research
Clinical Phenomapping Of Obese Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) encompasses>50% of all HF and is a heterogeneous syndrome with few proven treatments. Phenomapping is a machine-learning based technique for sub-group identification which we sought to perform in an obese HFpEF cohort, a predominant form of HFpEF in which phenomapping to date is limited. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Vivek Jani, Soumya Vungarala, Edwin Yoo, Steven Hsu, Virginia Hahn, David Kass, Kavita Sharma Tags: JNC-003 Source Type: research
Validation Of Bioelectrical Impedance Analysis Compared To DEXA To Measure Body Composition In Patients With Heart Failure With Preserved Ejection Fraction
Body composition, particularly appendicular lean mass index (ALMI), plays a pivotal role in patients with Heart Failure with Preserved Ejection Fraction (HFpEF) as it predicts exercise capacity and prognosis in this population. However, there are several barriers to routine implementation of body composition analysis (BCA) including availability and cost. There is an urgent need to identify cost-and time-effective methods to accurately measure body composition in patients with HFpEF. Bioelectrical impedance analysis (BIA) represents a widely-available, affordable, and quick method to estimate whole-and segmental body compo...
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Hannah Salmons, Hayley Billingsley, Syed Imran Ahmed, Roshanak Markley, MARCO GIUSEPPE DEL BUONO, Juan Ignacio Damonte, Sebastian Pinel, Lee Franco, Antonio Abbate, Salvatore Carbone Tags: JNC-004 Source Type: research
Post-exercise Oxygen Uptake Recovery Delay In Individuals With Left Ventricular Assist Device
Cardiopulmonary exercise testing (CPET) enables objective measurement multi-organ function during exercise in patients with heart failure (HF). Post-exercise oxygen uptake recovery delay (VO2RD), a non-invasive CPET metric, is the time when VO2 falls permanently below peak VO2 after loaded exercise. VO2RD reflects the inadequacy of cardiac output augmentation during incremental exercise and requisite “repayment” of O2 deficit. The magnitude of VO2RD is unknown in patients with left ventricular assist devices (LVAD). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Charounipha Soydara, Ilya Giverts, Joseph Campain, Katherine Milley, Janice M. Camuso, Tara Logan, Alexandra E. Anthony, Eriberto Michel, Asishana A. Osho, David A. D'Alessandro, Erin Coglianese, Corrine Y. Jurgens, Van-Khue Ton, Gregory D. Lewis Tags: NI-001 Source Type: research
I Just Don't Want It To Be Business, Business, Business: Facilitators And Barriers To Values Discussions Between Patients With A Left Ventricular Assist Device, Their Family Caregivers, And The Healthcare Team
Intentional exploration, or elicitation, of patient values (who and what matters most) in the context of left ventricular assist devices (LVADs) can assist in identifying health preferences and care priorities. Yet, the values elicitation experiences of individuals post LVAD-implantation have been understudied, particularly among historically minoritized African American (AA)/Black and rural-dwelling individuals. Understanding the facilitators and barriers to values discussions among individuals from these groups is critical to addressing disparities in outcomes and optimizing patient-centered decision-making. (Source: Jou...
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Avery C. Bechthold, Deborah B. Ejem, Colleen K. McIlvennan, Rachel D. Wells, Daniel D. Matlock, Christopher E. Knoepke, Marie A. Bakitas, James Nicholas Dionne-Odom Tags: NI-002 Source Type: research
Race And The Presence Of An Implantable Cardioverter Defibrillator Moderate The Relationship Between Gender And Quality Of Life
Women with heart failure (HF) have greater symptom burden and worse quality of life (QOL) compared to men with HF. Black, Indigenous, and people of color (BIPOC) are diagnosed with HF in larger numbers earlier in life, reporting worse QOL than their White counterparts. Despite these differences in diagnosis and QOL, women and BIPOC patients with HF have historically been undertreated with ICDs. These differences are due to both healthcare providers offering and patients accepting the devices in a differential manner. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Jennifer Miller, Debra Moser, Jessica Thompson, Misook Chung Tags: NI-003 Source Type: research
Cardiomems Use In Post Lung Transplant Patient Population
Little is known about the safety and impact of the pulmonary artery remote monitoring system, CardioMEMS, in reducing heart failure hospitalizations in patients following lung transplantation who developed heart failure with preserved ejection fraction (HFpEF). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Sarah Williams, Timothy Gong, Johanna Van Zyl, Melody Sherwood, Shelley Hall, Amit Alam Tags: NI-004 Source Type: research
