Achieving consensus, severity-graded definitions of Fontan-associated complications to characterize Fontan circulatory failure
For patients with single ventricle congenital heart disease, staged surgical palliation to total cavopulmonary anastomosis, or Fontan palliation, offers long-term survival but results in complex and compromised systemic circulation. These are manifest as obligate systemic venous hypertension that is often accompanied by hypoxia, compromised cardiac output, and impaired vascular function leading to circulatory failure1,2. This unique physiology can also lead to chronic dysfunction in other organ systems. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 5, 2024 Category: Cardiology Authors: Kurt R. Schumacher, Ari Cedars, Kiona Allen, David Goldberg, Adrianna Batazzi, Garrett Reichle, Frank DiPaola, David Selewski, Melissa Cousino, David N Rosenthal, Fontan Circulatory Failure Study Investigators Source Type: research
Wearable Sensors to Monitor Physical Activity in Heart Failure Clinical Trials: State-of-the-Art Review
Currently, the most common measure of symptoms in HF trials is based on a subset of questions from the Kansas City Cardiomyopathy Questionnaire (KCCQ) (4), a patient reported outcome (PRO) instrument. KCCQ also includes questions regarding other aspects of health-related quality of life as it pertains to heart-failure, including physical limitation. Analogously, the 6-minute walk test (6MWT) is a commonly used exercise test in HF trials, providing the distance walked in 6 minutes (6MWD) as a measure of submaximal exercise capacity. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 5, 2024 Category: Cardiology Authors: RUBEN BUENDIA, MARTIN KARPEFORS, FOLKE FOLKVALJON, ROBERT HUNTER, HENRIK SILLEN, LONG LUU, KIERAN DOCHERTY, MARTIN R COWIE Tags: Review Article Source Type: research
Obesity and Heart Failure: A New Era Begins
More than half of patients with heart failure (HF) have preserved left ventricular ejection fractions (HFpEFs), and roughly two-thirds of those individuals are living with obesity.1 Initially considered to be a bystander, it is now clear that obesity plays a pivotal causal role in HFpEF. The amount of excess body fat, particularly visceral fat, is associated with the degree of systemic inflammation, cardiac dysfunction, chamber remodeling, volume overload, blood-volume redistribution, and elevation in cardiac filling pressures. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Barry A. Borlaug, Tammy L. Kindel Tags: JCF Ignite! Source Type: research
Contemporary Diuretic Therapies for Acute Heart Failure: Time for a Desalination-Guided Approach?
Simultaneous and fast implementation of 4 different classes of guideline-directed medical therapy markedly improve symptoms as well as prognoses in patients with chronic heart failure (HF); beneficial effects on outcomes occur within weeks.1 Loop diuretics have a class I recommendation in all ejection-fraction classes to treat signs and symptoms of congestion, but robust clinical trial evidence to guide their use is sparse, which is reflected in a class IC (expert) guideline recommendation. Despite routine use of high-dose loop diuretics, many patients are discharged with residual congestion, which is a strong predictor of...
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: WILFRIED MULLENS, PIETER MARTENS Tags: JCF Ignite! Source Type: research
Contemporary Diuretic Therapies for Acute Heart Failure, time for a Desalination-Guided Approach?
Simultaneous and fast implementation of four different classes of guideline directed medical therapy markedly improves symptoms as well as prognosis in chronic heart failure patients, with beneficial effects on outcome occurring within weeks.1 Loop diuretics have a class I recommendation in all ejection fraction classes to treat signs and symptoms of congestion, but robust clinical trial evidence to guide their use is sparse, which is reflected in a class IC (expert) guideline recommendation. Despite routine use of high dose loop diuretics, many patients are discharged with residual congestion which is a strong predictor o...
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Wilfried Mullens, Pieter Martens Tags: JCF Ignite! Source Type: research
Personalized Pacing for HFpEF: myPACE
The misperception that pharmacologic heart rate lowering is beneficial in heart failure with preserved ejection fraction (HFpEF) has contributed to an overuse of beta-blockers. It is commonly argued that a slowing of heart rate provides more time for diastolic filling – However, this statement ignores that prolonged diastolic filling time can only increase ventricular filling volume (i.e., preload) if filling pressures increase, particularly if filling is restricted by a stiff left ventricle (LV) as shown in the Figure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Markus Meyer Tags: JCF Ignite! Source Type: research
Early Experience With Devices That Reduce Kidney Vascular Afterload From The Veins
Worsening renal failure due to cardiorenal syndrome (CRS) is noted in nearly one-third of acute decompensated heart failure (ADHF) admissions (1). The pathophysiology of CRS in patients with ADHF is a self-perpetuating cycle attributed to both poor renal artery perfusion, or “preload,” as well as increased renal venous congestion, or “afterload.” The etiology of reduced renal artery preload is multifactorial. Low cardiac output, activation of the renin-angiotensin-aldosterone system, and hypotension, lead to a compensatory vasoconstriction of the renal artery an d glomerular afferent arterioles as the kidney attemp...
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Alexander M. Spring, Enklajd Marsela, Ulrich P. Jorde Tags: JCF Ignite! Source Type: research
Going with the Flow: Device therapy for Heart Failure Complicated by Cardiorenal Syndrome
Cardiorenal syndrome (CRS) affects up to 40% of patients admitted with acute decompensated heart failure (ADHF) [1]. Although the precise mechanisms driving ADHF-CRS at the neurohormonal and cellular levels have not been fully elucidated, is it clear that the syndrome results from complex, multifactorial pathophysiologies, inclusive of reciprocal and unfavorable hemodynamic interactions between the heart and kidneys,[2] along with neurohormonal activation and fibrotic structural changes that contribute to progressive cardio-renal dysfunction and congestion. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Lindsey Aurora, Gillian Grafton, Jennifer Cowger Tags: JCF Ignite! Source Type: research
The Ideal Heart Rate for Heart Failure and Ejection Fraction > 40%: Both Myth and Magic?
Patients with heart failure and an ejection fraction (EF)>40% do not have a single disease.1 Patients with an EF of>40 to (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Milton Packer Tags: JCF Ignite! Source Type: research
Changing the Narrative About a Career in Heart Failure
I was staffing a routine heart transplant clinic, or so I thought. My current patient was a man who had been referred to me five years prior and had subsequently undergone left ventricular assist device implantation and then heart transplantation at my center. We were catching up on recent developments when his wife excitedly told me they had just met his donor's family. She then graciously showed me a picture of the donor's mother leaning forward, her ear on my patient's chest wall, listening to the heartbeat of her deceased son. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Mark H. Drazner Tags: JCF Ignite! Source Type: research
JCF Ignite: Obesity and Heart Failure: A New Era Begins
Over half of patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFpEF), and roughly two-thirds of those individuals are living with obesity.1 Initially considered to be a bystander, it is now clear that obesity plays a pivotal causal role in HFpEF. The amount of excess body fat, particularly visceral fat, is associated with the degree of systemic inflammation, cardiac dysfunction, chamber remodeling, volume overload, blood volume redistribution, and elevation in cardiac filling pressures. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 4, 2024 Category: Cardiology Authors: Barry A. Borlaug, Tammy L. Kindel Tags: JCF Ignite! Source Type: research
Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement
Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alterations in the brain. Cognition is critical for a myriad of self-care activities that are necessary to manage HF, and it also has a major impact on prognosis; consequently, cognitive impairment has important implications for self-care, medication management, function and independence, and life expectancy. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2024 Category: Cardiology Authors: PARAG GOYAL, ROBERT J. DIDOMENICO, SUSAN J. PRESSLER, CHINWE IBEH, CONNIE WHITE-WILLIAMS, LARRY A. ALLEN, EIRAN Z. GORODESKI, HFSA Scientific Statement Committee Members Tags: Review Article Source Type: research
Editorial Board
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2024 Category: Cardiology Source Type: research
Table of Contents
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2024 Category: Cardiology Source Type: research
Masthead
(Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - March 1, 2024 Category: Cardiology Source Type: research
