NETs implicated in COVID-19 in kids and adults
Nature Reviews Rheumatology, Published online: 11 August 2022; doi:10.1038/s41584-022-00830-3NETs implicated in COVID-19 in kids and adults (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 11, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

GWAS expands list of Sjögren syndrome risk loci
Nature Reviews Rheumatology, Published online: 11 August 2022; doi:10.1038/s41584-022-00828-xGWAS expands list of Sjögren syndrome risk loci (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 11, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

SARS-CoV-2 vaccine safe for young patients
Nature Reviews Rheumatology, Published online: 11 August 2022; doi:10.1038/s41584-022-00831-2SARS-CoV-2 vaccine safe for young patients (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 11, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Omicron evades immunity from vaccines
Nature Reviews Rheumatology, Published online: 11 August 2022; doi:10.1038/s41584-022-00829-wOmicron evades immunity from vaccines (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 11, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

How does age determine the development of human immune-mediated arthritis?
Nature Reviews Rheumatology, Published online: 10 August 2022; doi:10.1038/s41584-022-00814-3In this Review, the authors discuss age-related arthropathy and the similarities and differences between childhood loss of immune tolerance and adult development of immune-mediated arthritis, and develop three hypotheses describing age-related mechanisms that contribute to the onset of arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 10, 2022 Category: Rheumatology Authors: Yannick Degboe Sebastiaan J. Vastert Berent J. Prakken Iain B. McInnes Source Type: research

Risk variant regulates pDC hyperactivation in SLE
Nature Reviews Rheumatology, Published online: 04 August 2022; doi:10.1038/s41584-022-00825-0New research attempts to explore the cause of plasmacytoid dendritic cell hyperactivation in systemic lupus erythematosus by focusing on genetic risk variation. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 4, 2022 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Sex- and gender-related differences in psoriatic arthritis
Nature Reviews Rheumatology, Published online: 04 August 2022; doi:10.1038/s41584-022-00810-7This Review summarizes our understanding of sex- and gender-related differences in psoriatic arthritis, with a focus on disease progression and outcomes, underlying mechanisms and response to therapies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 4, 2022 Category: Rheumatology Authors: Sanjana Tarannum Ying-Ying Leung Sindhu R. Johnson Jessica Widdifield Vibeke Strand Paula Rochon Lihi Eder Source Type: research

Bimekizumab safe and effective for AS and PsA in long-term trials
Nature Reviews Rheumatology, Published online: 03 August 2022; doi:10.1038/s41584-022-00823-2Three new reports of results from two clinical trials of bimekizumab indicate that it is safe and efficacious for the long-term treatment of patients with ankylosing spondylitis or psoriatic arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 3, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research

FABP4 exacerbates RA
Nature Reviews Rheumatology, Published online: 03 August 2022; doi:10.1038/s41584-022-00824-1The findings of a new study suggest that the adipokine FABP4 promotes multiple pathological changes in rheumatoid arthritis and could represent a new therapeutic target. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 3, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Annexin A1 could help prevent periprosthetic bone loss
Nature Reviews Rheumatology, Published online: 02 August 2022; doi:10.1038/s41584-022-00822-3New research shows that annexin A1 has a protective role in periprosthetic osteolysis and could offer a therapeutic approach to this common cause of arthroplasty failure. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 2, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

A protective role for epidermal S100A9 in PsA
Nature Reviews Rheumatology, Published online: 02 August 2022; doi:10.1038/s41584-022-00821-4A new study uncovers a protective role for epidermal S100A9 in psoriasis and psoriatic arthritis, and highlights this alarmin as a potential biomarker of disease progression. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 2, 2022 Category: Rheumatology Authors: Jessica McHugh Source Type: research

FOXP3 splice variant is associated with autoimmune disease
Nature Reviews Rheumatology, Published online: 01 August 2022; doi:10.1038/s41584-022-00818-zNew research shows that one of the two main isoforms of the human FOXP3 transcription factor is associated with inflammatory transcriptional regulation and autoimmunity. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 1, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research

When underlying biology threatens the randomization principle — initial gout flares of urate-lowering therapy
Nature Reviews Rheumatology, Published online: 25 July 2022; doi:10.1038/s41584-022-00804-5The paradoxical increase in gout flare risk upon initiation of urate-lowering therapy presents challenges for the measurement and analysis of gout flares in clinical trials of urate-lowering therapy. In this Perspective, the authors highlight these issues and discuss potential solutions. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 25, 2022 Category: Rheumatology Authors: Hyon K. Choi Yuqing Zhang Nicola Dalbeth Source Type: research

Discontinuing methotrexate to enhance vaccine response
Nature Reviews Rheumatology, Published online: 22 July 2022; doi:10.1038/s41584-022-00817-0In patients with autoimmune rheumatic disease, methotrexate therapy has been associated with poor immune response to vaccines, including those intended to provide protection against COVID-19. Emerging evidence supports the practice of temporarily discontinuing this treatment in order to improve immunogenicity. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 22, 2022 Category: Rheumatology Authors: Ana C. Medeiros-Ribeiro Nadia E. Aikawa Source Type: research

Assessment of disease outcome measures in systemic sclerosis
Nature Reviews Rheumatology, Published online: 20 July 2022; doi:10.1038/s41584-022-00803-6Assessing systemic sclerosis (SSc) disease activity is challenging, and improved outcome measures are needed. This Review describes clinical and biochemical outcome measures of distinct features of SSc, with an emphasis on the dermatological manifestations and interstitial lung disease, including insights into biomarkers gained from single-cell RNA sequencing. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 20, 2022 Category: Rheumatology Authors: Robert Lafyatis Eleanor Valenzi Source Type: research