Is ethnicity linked to the severity of SLE manifestations?
Nature Reviews Rheumatology, Published online: 15 July 2019; doi:10.1038/s41584-019-0271-1Epidemiological data on the prevalence and severity of specific manifestations of systemic lupus erythematosus (SLE) among different ethnic groups are now emerging. The use of rigorous epidemiological methods should enable a better understanding of these features of SLE in different ethnic groups, which could influence disease management. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 15, 2019 Category: Rheumatology Authors: Naureen Kabani Ellen M. Ginzler Source Type: research

Surgical and tissue engineering strategies for articular cartilage and meniscus repair
Nature Reviews Rheumatology, Published online: 11 July 2019; doi:10.1038/s41584-019-0255-1Tissue engineering strategies to repair articular cartilage and menisci are advancing rapidly. This Review provides an overview of surgical and tissue engineering approaches in current use and outlines exciting developments in the field. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 11, 2019 Category: Rheumatology Authors: Heenam Kwon Wendy E. Brown Cassandra A. Lee Dean Wang Nikolaos Paschos Jerry C. Hu Kyriacos A. Athanasiou Source Type: research

Immunofibroblasts are the cornerstone of TLS formation in pSS
Nature Reviews Rheumatology, Published online: 11 July 2019; doi:10.1038/s41584-019-0273-zImmunofibroblasts are the cornerstone of TLS formation in pSS (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 11, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions
Nature Reviews Rheumatology, Published online: 10 July 2019; doi:10.1038/s41584-019-0256-0The relationship between inflammation, cardiovascular disease and metabolic comorbidities in rheumatoid arthritis and psoriatic arthritis is complex. Understanding these relationships is important for the management of both diseases, as cardiometabolic comorbidities place a considerable burden on these patients. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 10, 2019 Category: Rheumatology Authors: Lyn D. Ferguson Stefan Siebert Iain B. McInnes Naveed Sattar Source Type: research

T follicular helper cells and T follicular regulatory cells in rheumatic diseases
Nature Reviews Rheumatology, Published online: 09 July 2019; doi:10.1038/s41584-019-0254-2T follicular helper cells and T follicular regulatory cells tightly control the production of (auto)antibodies by B cells. Understanding their phenotypes and how the function of these cells is dysregulated in rheumatic diseases will aid future therapeutic development. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 9, 2019 Category: Rheumatology Authors: Jun Deng Yunbo Wei V álter R. Fonseca Luis Graca Di Yu Source Type: research

Cartilage-on-a-chip to aid OA drug development
Nature Reviews Rheumatology, Published online: 09 July 2019; doi:10.1038/s41584-019-0270-2Cartilage-on-a-chip to aid OA drug development (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 9, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

The choroid plexus: a cellular site of entry into the brain in NPSLE?
Nature Reviews Rheumatology, Published online: 05 July 2019; doi:10.1038/s41584-019-0267-xThe choroid plexus: a cellular site of entry into the brain in NPSLE? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 5, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Neuronal Fcγ receptors mediate joint pain in arthritis
Nature Reviews Rheumatology, Published online: 05 July 2019; doi:10.1038/s41584-019-0269-8Neuronal Fcγ receptors mediate joint pain in arthritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 5, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Gut commensal implicated in APS
Nature Reviews Rheumatology, Published online: 04 July 2019; doi:10.1038/s41584-019-0268-9Gut commensal implicated in APS (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 4, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Mother–daughter inheritance patterns in OA
Nature Reviews Rheumatology, Published online: 04 July 2019; doi:10.1038/s41584-019-0264-0Mother–daughter inheritance patterns in OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 4, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Anti-NGF therapy improves osteoarthritis pain
Nature Reviews Rheumatology, Published online: 04 July 2019; doi:10.1038/s41584-019-0266-yAnti-NGF therapy improves osteoarthritis pain (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 4, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Biosimilar for teriparatide safe and effective
Nature Reviews Rheumatology, Published online: 04 July 2019; doi:10.1038/s41584-019-0263-1Biosimilar for teriparatide safe and effective (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 4, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Epstein–Barr virus reactivation linked to SLE
Nature Reviews Rheumatology, Published online: 04 July 2019; doi:10.1038/s41584-019-0265-zEpstein–Barr virus reactivation linked to SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 4, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Author Correction: New therapies for systemic lupus erythematosus — past imperfect, future tense
Nature Reviews Rheumatology, Published online: 03 July 2019; doi:10.1038/s41584-019-0262-2Author Correction: New therapies for systemic lupus erythematosus — past imperfect, future tense (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 3, 2019 Category: Rheumatology Authors: Grainne Murphy David A. Isenberg Source Type: research

The structure, specificity and function of anti-citrullinated protein antibodies
Nature Reviews Rheumatology, Published online: 28 June 2019; doi:10.1038/s41584-019-0244-4In this Perspectives article, the authors present how various types of anti-citrullinated protein antibodies (ACPAs) differ based on the structural interactions of these antibodies with their citrullinated antigens, and examine the potential consequences for ACPA-mediated effector functions. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 28, 2019 Category: Rheumatology Authors: Changrong Ge Rikard Holmdahl Source Type: research

Functionally distinct fibroblast subsets in RA
Nature Reviews Rheumatology, Published online: 27 June 2019; doi:10.1038/s41584-019-0261-3Functionally distinct fibroblast subsets in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 27, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

IL-6: linking chronic inflammation and vascular calcification
Nature Reviews Rheumatology, Published online: 24 June 2019; doi:10.1038/s41584-019-0259-xNew data highlight the contribution of IL-6 to vascular calcification in chronic inflammation. Given that increased vascular calcification and accelerated atherosclerosis occur in patients with chronic inflammatory diseases, new therapies that block the IL-6 pathway might reduce the risk of cardiovascular events in these patients. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 24, 2019 Category: Rheumatology Authors: Raquel L ópez-Mejías Miguel A. Gonz ález-Gay Source Type: research

Origins of synovial macrophages revealed
Nature Reviews Rheumatology, Published online: 24 June 2019; doi:10.1038/s41584-019-0260-4Origins of synovial macrophages revealed (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 24, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Systemic effects of IL-17 in inflammatory arthritis
Nature Reviews Rheumatology, Published online: 21 June 2019; doi:10.1038/s41584-019-0243-5The effects of IL-17 on the joints in inflammatory arthritis are well-documented, but less is known about its systemic effects. In this Review, Beringer and Miossec discuss the effects of IL-17 on muscle, the cardiovascular system and the liver. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 21, 2019 Category: Rheumatology Authors: Audrey Beringer Pierre Miossec Source Type: research

Towards a new classification of systemic sclerosis
Nature Reviews Rheumatology, Published online: 19 June 2019; doi:10.1038/s41584-019-0257-zAnalysis of data from the European Scleroderma Trials and Research (EUSTAR) cohort has initially identified six subsets of systemic sclerosis (SSc), as opposed to the binary classification of limited and diffuse cutaneous SSc. We now move closer to a more actionable SSc classification for improved clinical care and trial design. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 19, 2019 Category: Rheumatology Authors: Monique Hinchcliff J. Matthew Mahoney Source Type: research

New insights into myositis genetics
Nature Reviews Rheumatology, Published online: 18 June 2019; doi:10.1038/s41584-019-0258-yNew insights into myositis genetics (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 18, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Helminths and microbiota — partners in arthritis prevention?
Nature Reviews Rheumatology, Published online: 17 June 2019; doi:10.1038/s41584-019-0253-3Changes in the gut microbiome are thought to be important environmental triggers for inflammatory forms of arthritis, including rheumatoid arthritis. Could interactions between gut parasites, such as helminths, and gut microbiota be the key to normalizing an unbalanced microbiome and preventing arthritis? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 17, 2019 Category: Rheumatology Authors: Gillian Coakley Nicola L. Harris Source Type: research

Establishing outcome measures in early knee osteoarthritis
Nature Reviews Rheumatology, Published online: 14 June 2019; doi:10.1038/s41584-019-0237-3Establishing suitable outcome measures is an important goal for the classification and monitoring of patients with early knee osteoarthritis. This Perspectives article highlights various outcome measures that have potential use in clinical and/or research settings for early knee osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 14, 2019 Category: Rheumatology Authors: Carolyn A. Emery Jackie L. Whittaker Armaghan Mahmoudian L. Stefan Lohmander Ewa M. Roos Kim L. Bennell Clodagh M. Toomey Raylene A. Reimer Dylan Thompson Janet L. Ronsky Gregor Kuntze David G. Lloyd Thomas Andriacchi Martin Englund Virginia B. Kraus Elen Source Type: research

The immunobiology of MIF: function, genetics and prospects for precision medicine
Nature Reviews Rheumatology, Published online: 13 June 2019; doi:10.1038/s41584-019-0238-2The pleiotropic cytokine macrophage migration inhibitory factor (MIF) is involved in the pathogenesis of autoimmune inflammatory disorders. This Review discusses MIF biology and signalling, its mechanisms of action and its involvement in rheumatic diseases, including opportunities for targeted therapies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 13, 2019 Category: Rheumatology Authors: Insoo Kang Richard Bucala Source Type: research

Stratifying management of rheumatic disease for pregnancy and breastfeeding
Nature Reviews Rheumatology, Published online: 11 June 2019; doi:10.1038/s41584-019-0240-8Pregnancy can affect the underlying disease and vice versa, and drug therapy may need to be altered before, during and after pregnancy. With careful planning, monitoring and treatment, most women with inflammatory rheumatic diseases can have successful pregnancies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 11, 2019 Category: Rheumatology Authors: Ian Giles Chee-Seng Yee Caroline Gordon Source Type: research

Engineered fusion protein disrupts CD40 signalling
Nature Reviews Rheumatology, Published online: 05 June 2019; doi:10.1038/s41584-019-0252-4Engineered fusion protein disrupts CD40 signalling (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 5, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

New therapies for systemic lupus erythematosus — past imperfect, future tense
Nature Reviews Rheumatology, Published online: 05 June 2019; doi:10.1038/s41584-019-0235-5A series of successive failures of new therapies for systemic lupus erythematosus (SLE) in clinical trials has left clinicians with limited options to treat this disease. Could any of the therapies currently in development offer hope for patients with SLE? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 5, 2019 Category: Rheumatology Authors: Grainne Murphy David A. Isenberg Source Type: research

Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis
Nature Reviews Rheumatology, Published online: 05 June 2019; doi:10.1038/s41584-019-0249-zSingle-cell analysis identifies key pathways and prognostic markers in lupus nephritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 5, 2019 Category: Rheumatology Authors: Ellen F. Carney Source Type: research

IL-36 inhibition to treat OA
Nature Reviews Rheumatology, Published online: 04 June 2019; doi:10.1038/s41584-019-0250-6IL-36 inhibition to treat OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 4, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Rare variants in SLE risk genes drive disease
Nature Reviews Rheumatology, Published online: 04 June 2019; doi:10.1038/s41584-019-0251-5Rare variants in SLE risk genes drive disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 4, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Pregnancy outcomes in patients with MCTD
Nature Reviews Rheumatology, Published online: 03 June 2019; doi:10.1038/s41584-019-0246-2Pregnancy outcomes in patients with MCTD (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Hyperuricaemia or gout in patients with RA
Nature Reviews Rheumatology, Published online: 03 June 2019; doi:10.1038/s41584-019-0248-0Hyperuricaemia or gout in patients with RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

ACPA-negative RA divided into clinical subsets
Nature Reviews Rheumatology, Published online: 03 June 2019; doi:10.1038/s41584-019-0245-3ACPA-negative RA divided into clinical subsets (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Nintedanib slows ILD progression in SSc
Nature Reviews Rheumatology, Published online: 03 June 2019; doi:10.1038/s41584-019-0247-1Nintedanib slows ILD progression in SSc (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

The rise of peripheral T helper cells in autoimmune disease
Nature Reviews Rheumatology, Published online: 28 May 2019; doi:10.1038/s41584-019-0241-7Studies across multiple autoimmune diseases, including rheumatoid arthritis and coeliac disease, have identified a pathologically expanded PD1hiCXCR5−CD4+ T cell population that accumulates in inflamed tissues. Can this peripheral T helper cell population be harnessed as a predictive biomarker or targeted therapeutically in these diseases? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 28, 2019 Category: Rheumatology Authors: Deepak A. Rao Source Type: research

Two targets are better than one
Nature Reviews Rheumatology, Published online: 24 May 2019; doi:10.1038/s41584-019-0242-6Two targets are better than one (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 24, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Mouse models for human hyperuricaemia: a critical review
Nature Reviews Rheumatology, Published online: 22 May 2019; doi:10.1038/s41584-019-0222-xHyperuricaemia is a risk factor for gout, and mouse models of this condition can help dissect the underlying regulatory mechanisms. However, these models come with both advantages and disadvantages, and interpreting and comparing data from these models can be challenging. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 22, 2019 Category: Rheumatology Authors: Jie Lu Nicola Dalbeth Huiyong Yin Changgui Li Tony R. Merriman Wen-Hua Wei Source Type: research

Patrolling monocytes promote kidney disease
Nature Reviews Rheumatology, Published online: 20 May 2019; doi:10.1038/s41584-019-0239-1Patrolling monocytes promote kidney disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 20, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications
Nature Reviews Rheumatology, Published online: 15 May 2019; doi:10.1038/s41584-019-0219-5The HLA region is strongly associated with many rheumatic diseases, including inflammatory arthritis. In this Review, potential mechanisms underpinning these associations are discussed, as are the clinical implications of HLA associations for the diagnosis and treatment of these diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 15, 2019 Category: Rheumatology Authors: Robert Busch Simon Kollnberger Elizabeth D. Mellins Source Type: research

Should 18F-FDG-PET imaging be used in the diagnosis of GCA?
Should 18F-FDG-PET imaging be used in the diagnosis of GCA?Should 18F-FDG-PET imaging be used in the diagnosis of GCA?, Published online: 09 May 2019; doi:10.1038/s41584-019-0236-418F-FDG-PET is not currently recommended for use in the diagnosis of cranial giant cell arteritis (GCA). A new study has compared 18F-FDG-PET with temporal artery biopsy and clinical diagnosis as gold standards, but is 18F-FDG-PET accurate enough to be used on temporal arteries? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2019 Category: Rheumatology Authors: Dario Camellino Christian Dejaco Source Type: research

Therapeutic options for targeting inflammatory osteoarthritis pain
Therapeutic options for targeting inflammatory osteoarthritis pain, Published online: 08 May 2019; doi:10.1038/s41584-019-0221-yPain management is presently the focus of osteoarthritis (OA) therapy, but traditional pain-relieving drugs such as NSAIDs and glucocorticoids have limited utility. In this Review, the next generation of OA analgesics and their potential mechanisms of action are discussed. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 8, 2019 Category: Rheumatology Authors: Philip G. Conaghan Andrew D. Cook John A. Hamilton Paul P. Tak Source Type: research

Single-cell technologies — studying rheumatic diseases one cell at a time
Single-cell technologies — studying rheumatic diseases one cell at a timeSingle-cell technologies — studying rheumatic diseases one cell at a time, Published online: 07 May 2019; doi:10.1038/s41584-019-0220-zSingle-cell sequencing technologies enable transcriptomic, epigenomic and proteomic analysis of rare or heterogeneous populations of cells. In this Review, Kuo and colleagues discuss current and future uses of single-cell sequencing technologies for rheumatology research. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 7, 2019 Category: Rheumatology Authors: Peggie Cheung Purvesh Khatri Paul J. Utz Alex J. Kuo Source Type: research

FRA1 in macrophages promotes arthritis
FRA1 in macrophages promotes arthritis, Published online: 03 May 2019; doi:10.1038/s41584-019-0233-7FRA1 in macrophages promotes arthritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Preventing NETosis to reduce thrombosis
Preventing NETosis to reduce thrombosis, Published online: 03 May 2019; doi:10.1038/s41584-019-0234-6Preventing NETosis to reduce thrombosis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 3, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

TIGIT-Ig shows therapeutic potential in SLE
TIGIT-Ig shows therapeutic potential in SLE, Published online: 02 May 2019; doi:10.1038/s41584-019-0230-xTIGIT-Ig shows therapeutic potential in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Namilumab improves RA symptoms
Namilumab improves RA symptoms, Published online: 02 May 2019; doi:10.1038/s41584-019-0231-9Namilumab improves RA symptoms (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Daily atorvastatin safe for patients with RA
Daily atorvastatin safe for patients with RA, Published online: 02 May 2019; doi:10.1038/s41584-019-0229-3Daily atorvastatin safe for patients with RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Amyloid-PET: a new tool for diagnosing IBM?
Amyloid-PET: a new tool for diagnosing IBM?, Published online: 02 May 2019; doi:10.1038/s41584-019-0223-9Inclusion body myositis (IBM) and polymyositis can normally be distinguished on the basis of clinical features. However, patients with an atypical disease presentation, particularly those with early-stage disease, can be challenging to diagnose. Can imaging with amyloid-PET help distinguish these two diseases? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Iago Pinal-Fernandez Andrew L. Mammen Source Type: research

Choline uptake is vital for IL-1β-driven inflammation
Choline uptake is vital for IL-1β-driven inflammationCholine uptake is vital for IL-1β-driven inflammation, Published online: 02 May 2019; doi:10.1038/s41584-019-0228-4Choline uptake is vital for IL-1β-driven inflammation (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Isobel Leake Source Type: research

Burden of musculoskeletal diseases increasing
Burden of musculoskeletal diseases increasing, Published online: 02 May 2019; doi:10.1038/s41584-019-0232-8Burden of musculoskeletal diseases increasing (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research