Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
Nature Reviews Rheumatology, Published online: 08 July 2020; doi:10.1038/s41584-020-0455-8Various types of programmed cell death, including necroptosis, pyroptosis, NETosis and apoptosis, contribute to acute and chronic inflammation, and dysregulation of these pathways is implicated in rheumatic diseases. Understanding the mechanisms and overlap between cell death pathways might lead to new therapies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 8, 2020 Category: Rheumatology Authors: Holly Anderton Ian P. Wicks John Silke Source Type: research

Gene expression profiles in muscle differ in myositis subtypes
Nature Reviews Rheumatology, Published online: 07 July 2020; doi:10.1038/s41584-020-0468-3Gene expression profiles in muscle differ in myositis subtypes (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 7, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

New data emerging on outcomes for patients with COVID-19 and rheumatic diseases
Nature Reviews Rheumatology, Published online: 03 July 2020; doi:10.1038/s41584-020-0463-8New data emerging on outcomes for patients with COVID-19 and rheumatic diseases (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 3, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Long-term efficacy of canakinumab in crFMF
Nature Reviews Rheumatology, Published online: 02 July 2020; doi:10.1038/s41584-020-0466-5Long-term efficacy of canakinumab in crFMF (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 2, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Global prevalence of JIA, JSLE and club foot
Nature Reviews Rheumatology, Published online: 02 July 2020; doi:10.1038/s41584-020-0465-6Global prevalence of JIA, JSLE and club foot (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 2, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Increased risk of self-harm in fibromyalgia
Nature Reviews Rheumatology, Published online: 02 July 2020; doi:10.1038/s41584-020-0467-4Increased risk of self-harm in fibromyalgia (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 2, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

In-hospital SLE mortality has fallen and plateaued
Nature Reviews Rheumatology, Published online: 02 July 2020; doi:10.1038/s41584-020-0464-7In-hospital SLE mortality has fallen and plateaued (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 2, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Targeted delivery of immunosuppressant in SLE
Nature Reviews Rheumatology, Published online: 01 July 2020; doi:10.1038/s41584-020-0462-9Targeted delivery of immunosuppressant in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - July 1, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Biomarker development for axial spondyloarthritis
Nature Reviews Rheumatology, Published online: 30 June 2020; doi:10.1038/s41584-020-0450-0Biomarkers help in the diagnosis and monitoring of disease, but robust biomarkers can be difficult to discover and validate. This Review explores the state of biomarker discovery for axial spondyloarthritis and suggests future developments to advance this field. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 30, 2020 Category: Rheumatology Authors: Matthew A. Brown Zhixiu Li Kim-Anh L ê Cao Source Type: research

IL-23 promotes arthritic and inflammatory pain
Nature Reviews Rheumatology, Published online: 30 June 2020; doi:10.1038/s41584-020-0460-yIL-23 promotes arthritic and inflammatory pain (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 30, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

NETs directly injure cartilage in RA
Nature Reviews Rheumatology, Published online: 29 June 2020; doi:10.1038/s41584-020-0459-4NETs directly injure cartilage in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 29, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

In silico tools predict effects of drugs on bone remodelling
Nature Reviews Rheumatology, Published online: 24 June 2020; doi:10.1038/s41584-020-0457-6Researchers have developed an in silico (computer) platform that couples tissue adaptation with cellular and molecular interactions to simulate bone adaptation to mechanical loading and progress and treatment of metabolic bone diseases. What is the benefit of such in silico tools, and how can credibility of the simulation outcomes be established? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 24, 2020 Category: Rheumatology Authors: Liesbet Geris Source Type: research

Complement: the missing genetic link for SLE and pSS?
Nature Reviews Rheumatology, Published online: 19 June 2020; doi:10.1038/s41584-020-0456-7Complement: the missing genetic link for SLE and pSS? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 19, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

COVID-19 revisiting inflammatory pathways of arthritis
Nature Reviews Rheumatology, Published online: 19 June 2020; doi:10.1038/s41584-020-0451-zThis Perspective article explores similarities in the inflammatory processes underlying coronavirus disease 2019 (COVID-19) and rheumatoid arthritis, including the role of pro-inflammatory cytokines and the potential of anti-cytokine therapies to treat COVID-19, as well as the effect of the COVID-19 pandemic on rheumatology. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 19, 2020 Category: Rheumatology Authors: Georg Schett Bernhard Manger David Simon Roberto Caporali Source Type: research

Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors
Nature Reviews Rheumatology, Published online: 15 June 2020; doi:10.1038/s41584-020-0441-1Gout is a chronic crystal deposition disorder in which sustained hyperuricaemia leads to formation and deposition of monosodium urate crystals in the joints. The prevalence and incidence of gout are increasing globally, which may be related to changes in the prevalence of gout risk factors (such as obesity) and comorbidities. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 15, 2020 Category: Rheumatology Authors: Mats Dehlin Lennart Jacobsson Edward Roddy Source Type: research

A guide to managing reproductive health in rheumatology
Nature Reviews Rheumatology, Published online: 09 June 2020; doi:10.1038/s41584-020-0443-zRheumatologists lack guidance on how to manage the reproductive health of their patients, and communication to patients on reproductive health issues is an unmet need. New guidelines from the ACR provide support in the counselling of both female and male patients on the different aspects of their reproductive life. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 9, 2020 Category: Rheumatology Authors: Angela Tincani Laura Andreoli Source Type: research

Synovial fibroblast expansion in RA is driven by Notch signalling
Nature Reviews Rheumatology, Published online: 08 June 2020; doi:10.1038/s41584-020-0453-xSynovial fibroblast expansion in RA is driven by Notch signalling (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 8, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Adopting PROs in virtual and outpatient management of RA
Nature Reviews Rheumatology, Published online: 05 June 2020; doi:10.1038/s41584-020-0449-6The COVID-19 pandemic has catalysed the sudden adoption of telemedicine in the management of rheumatic diseases. In this abrupt transition from in-person visits to telemedicine, can patient-reported outcomes (PROs) help ensure that we continue to achieve optimum disease control and address the concerns of people living with rheumatoid arthritis? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 5, 2020 Category: Rheumatology Authors: Peter C. Taylor Source Type: research

Uncovering the pro-resolving gene network in RA
Nature Reviews Rheumatology, Published online: 05 June 2020; doi:10.1038/s41584-020-0452-yUncovering the pro-resolving gene network in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 5, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Minimizing efficacy differences between phase II and III RCTs
Nature Reviews Rheumatology, Published online: 05 June 2020; doi:10.1038/s41584-020-0446-9Results from phase II randomized controlled trials (RCTs) determine whether promising therapeutics will progress to phase III. According to detailed analyses in rheumatoid arthritis and psoriatic arthritis, phase II efficacy data systematically overestimate subsequent phase III results, raising the question of how this discrepancy might be addressed in future RCTs. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 5, 2020 Category: Rheumatology Authors: Vibeke Strand Source Type: research

Autoimmune and inflammatory diseases following COVID-19
Nature Reviews Rheumatology, Published online: 04 June 2020; doi:10.1038/s41584-020-0448-7Emerging reports show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection precedes the appearance of various autoimmune and autoinflammatory diseases, including paediatric inflammatory multisystemic syndrome (PIMS) or multisystem inflammatory syndrome in children (MIS-C), thus adding to the growing mystery of this virus and raising questions about the nature of its link with autoimmune and autoinflammatory sequelae. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 4, 2020 Category: Rheumatology Authors: Caroline Galeotti Jagadeesh Bayry Source Type: research

Atherosclerotic cardiovascular disease prevention in rheumatoid arthritis
Nature Reviews Rheumatology, Published online: 03 June 2020; doi:10.1038/s41584-020-0428-yAtherosclerotic cardiovascular disease is a major cause of morbidity and mortality in patients with rheumatoid arthritis. In this Review, Semb and colleagues outline atherosclerotic cardiovascular disease risk management and prevention for patients with rheumatoid arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 3, 2020 Category: Rheumatology Authors: Anne Grete Semb Eirik Ikdahl Grunde Wibetoe Cynthia Crowson Silvia Rollefstad Source Type: research

Harnessing plant viruses to treat autoimmune diseases
Nature Reviews Rheumatology, Published online: 29 May 2020; doi:10.1038/s41584-020-0445-xHarnessing plant viruses to treat autoimmune diseases (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 29, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

Targeting FLS signalling in RA
Nature Reviews Rheumatology, Published online: 27 May 2020; doi:10.1038/s41584-020-0444-yTargeting FLS signalling in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 27, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Kawasaki disease: pathophysiology and insights from mouse models
Nature Reviews Rheumatology, Published online: 26 May 2020; doi:10.1038/s41584-020-0426-0This Review outlines the pathophysiology of Kawasaki disease and discusses the progress gained from experimental mouse models and their potential therapeutic translation to human disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 26, 2020 Category: Rheumatology Authors: Magali Noval Rivas Moshe Arditi Source Type: research

TET1: an epigenetic controller of OA
Nature Reviews Rheumatology, Published online: 18 May 2020; doi:10.1038/s41584-020-0442-0TET1: an epigenetic controller of OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 18, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Early referral matters for RA outcomes
Nature Reviews Rheumatology, Published online: 12 May 2020; doi:10.1038/s41584-020-0437-xEarly referral matters for RA outcomes (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 12, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Increased risk of infection-related death in SLE
Nature Reviews Rheumatology, Published online: 12 May 2020; doi:10.1038/s41584-020-0438-9Increased risk of infection-related death in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 12, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

MMF comparable to cyclophosphamide in AAV
Nature Reviews Rheumatology, Published online: 12 May 2020; doi:10.1038/s41584-020-0440-2MMF comparable to cyclophosphamide in AAV (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 12, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Anti-TNF response falls short in real-world cohort
Nature Reviews Rheumatology, Published online: 12 May 2020; doi:10.1038/s41584-020-0439-8Anti-TNF response falls short in real-world cohort (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 12, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Disease onset goes with its gut in RA
Nature Reviews Rheumatology, Published online: 11 May 2020; doi:10.1038/s41584-020-0436-yDisease onset goes with its gut in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
Nature Reviews Rheumatology, Published online: 11 May 2020; doi:10.1038/s41584-020-0413-5Fibroblast-like synoviocytes in rheumatoid arthritis have an aggressive phenotype caused, in part, by epigenetic imprinting, which contributes to various pathological processes. Understanding the mechanisms underlying the cell abnormalities and phenotypes, including their spatial and temporal differences, could lead to new therapies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2020 Category: Rheumatology Authors: Gyrid Nygaard Gary S. Firestein Source Type: research

HIF1α blockade reduces kidney injury in lupus nephritis
Nature Reviews Rheumatology, Published online: 06 May 2020; doi:10.1038/s41584-020-0430-4HIF1α blockade reduces kidney injury in lupus nephritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 6, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

Finding a unifying SLE expression signature in a sea of heterogeneity
Nature Reviews Rheumatology, Published online: 05 May 2020; doi:10.1038/s41584-020-0422-4The heterogeneity of systemic lupus erythematosus (SLE) confounds the diagnosis and treatment of this disease, and attempts at disease stratification are nascent. Researchers have identified a common set of biomarkers in patients with SLE that could identify new therapeutic targets and lead to new clinical assays to help address this issue. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 5, 2020 Category: Rheumatology Authors: Edward Wakeland Prithvi Raj Source Type: research

Targeting adenosine in SSc
Nature Reviews Rheumatology, Published online: 05 May 2020; doi:10.1038/s41584-020-0435-zTargeting adenosine in SSc (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 5, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Hospitalization for infection on the rise in gout
Nature Reviews Rheumatology, Published online: 04 May 2020; doi:10.1038/s41584-020-0432-2Hospitalization for infection on the rise in gout (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 4, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

GCA relapse common in ustekinumab trial
Nature Reviews Rheumatology, Published online: 04 May 2020; doi:10.1038/s41584-020-0434-0GCA relapse common in ustekinumab trial (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 4, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Tanezumab improves difficult-to-treat OA
Nature Reviews Rheumatology, Published online: 04 May 2020; doi:10.1038/s41584-020-0431-3Tanezumab improves difficult-to-treat OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 4, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Physical therapy better than steroids for knee OA
Nature Reviews Rheumatology, Published online: 04 May 2020; doi:10.1038/s41584-020-0433-1Physical therapy better than steroids for knee OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 4, 2020 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Opioid and Hedgehog signalling pathways converge to modulate OA
Nature Reviews Rheumatology, Published online: 01 May 2020; doi:10.1038/s41584-020-0429-xOpioid and Hedgehog signalling pathways converge to modulate OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 1, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

Combating physical inactivity during the COVID-19 pandemic
Nature Reviews Rheumatology, Published online: 30 April 2020; doi:10.1038/s41584-020-0427-zPhysical inactivity is common during periods of self-isolation, but for patients with rheumatic diseases, there are crucial benefits to be gained from maintaining an active lifestyle throughout the COVID-19 pandemic. Patients should be provided with support to maintain physical activity and avoid prolonged periods of time spent sitting. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 30, 2020 Category: Rheumatology Authors: Ana J éssica Pinto David W. Dunstan Neville Owen Eloisa Bonf á Bruno Gualano Source Type: research

Metabolic messengers of cell death
Nature Reviews Rheumatology, Published online: 29 April 2020; doi:10.1038/s41584-020-0424-2Metabolic messengers of cell death (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 29, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Microbiota-derived metabolites help regulatory B cells suppress arthritis
Nature Reviews Rheumatology, Published online: 28 April 2020; doi:10.1038/s41584-020-0425-1Microbiota-derived metabolites help regulatory B cells suppress arthritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 28, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets
Nature Reviews Rheumatology, Published online: 27 April 2020; doi:10.1038/s41584-020-0409-1Peptidylarginine deiminases (PADs) citrullinate proteins, thereby creating the targets of the autoimmune response in rheumatoid arthritis; yet, in some individuals, PADs themselves can be the targets of immune responses. The mechanisms behind this complex relationship are unravelled in this Review. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 27, 2020 Category: Rheumatology Authors: Ashley M. Curran Pooja Naik Jon T. Giles Erika Darrah Source Type: research

Translating IL-6 biology into effective treatments
Nature Reviews Rheumatology, Published online: 23 April 2020; doi:10.1038/s41584-020-0419-zIn this Perspective article, the authors recount the earliest stages of translational research into IL-6 biology and the subsequent development of therapeutic IL-6 pathway inhibitors for the treatment of autoimmune rheumatic diseases and potentially numerous other indications. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 23, 2020 Category: Rheumatology Authors: Ernest H. Choy Fabrizio De Benedetti Tsutomu Takeuchi Misato Hashizume Markus R. John Tadamitsu Kishimoto Source Type: research

PDGF-BB is the key to unlocking pathological angiogenesis in OA
Nature Reviews Rheumatology, Published online: 22 April 2020; doi:10.1038/s41584-020-0423-3PDGF-BB is the key to unlocking pathological angiogenesis in OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 22, 2020 Category: Rheumatology Authors: Joanna Clarke Source Type: research

Learning from similarities between vaccine responses and SLE
Nature Reviews Rheumatology, Published online: 17 April 2020; doi:10.1038/s41584-020-0421-5Baseline immune variation predicts immune responses during vaccination, and the gene signatures capturing such immune variation seem to correlate with systemic lupus erythematosus (SLE) disease activity. Will the definition of these gene sets enable the development of the much needed concept of personalized medicine in SLE? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 17, 2020 Category: Rheumatology Authors: Marie Wahren-Herlenius Lars R önnblom Source Type: research

Interplay between genetics and epigenetics in osteoarthritis
Nature Reviews Rheumatology, Published online: 09 April 2020; doi:10.1038/s41584-020-0407-3Emerging data on the interactions between epigenetic mechanisms and genetic risk loci are providing insights into the underlying mechanisms of osteoarthritis that could identify novel and exploitable therapeutic targets (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 9, 2020 Category: Rheumatology Authors: Sarah J. Rice Frank Beier David A. Young John Loughlin Source Type: research

IL-23 inhibitor guselkumab shows promise for PsA
Nature Reviews Rheumatology, Published online: 07 April 2020; doi:10.1038/s41584-020-0420-6IL-23 inhibitor guselkumab shows promise for PsA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 7, 2020 Category: Rheumatology Authors: Jessica McHugh Source Type: research

The COVID-19 Global Rheumatology Alliance: collecting data in a pandemic
Nature Reviews Rheumatology, Published online: 02 April 2020; doi:10.1038/s41584-020-0418-0The global COVID-19 pandemic has the potential to severely affect those with rheumatic diseases or who are taking immunosuppressive therapies. Information is lacking as to how these groups will fare if they become infected. A global alliance has rapidly formed to try to address this information deficit. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 2, 2020 Category: Rheumatology Authors: Philip C. Robinson Jinoos Yazdany Source Type: research