Integrated multi-omics approaches to improve classification of chronic kidney disease
Nature Reviews Nephrology, Published online: 18 May 2020; doi:10.1038/s41581-020-0286-5Classification of kidney diseases according to their molecular mechanisms has potential to improve patient outcomes through the identification of targeted therapeutic approaches. This Review provides an overview of the ways in which omics and other data types can be integrated to enhance our understanding of the mechanisms underlying kidney function and failure. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 18, 2020 Category: Urology & Nephrology Authors: Sean Eddy Laura H. Mariani Matthias Kretzler Source Type: research

COVID-19: implications for immunosuppression in kidney disease and transplantation
Nature Reviews Nephrology, Published online: 14 May 2020; doi:10.1038/s41581-020-0305-6The coronavirus disease 2019 (COVID-19) pandemic poses important challenges to the care of patients with immune-mediated kidney diseases and to kidney transplant recipients. Here, we discuss the management of immunosuppression for these patients during the pandemic and suggest potential approaches that could be considered in the absence of validated strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 14, 2020 Category: Urology & Nephrology Authors: Andreas Kronbichler Philipp Gauckler Martin Windpessl Jae Il Shin Vivekanand Jha Brad H. Rovin Rainer Oberbauer Source Type: research

Water use in dialysis: environmental considerations
Nature Reviews Nephrology, Published online: 14 May 2020; doi:10.1038/s41581-020-0296-3Current dialysis technologies require vast quantities of pure water; however, water is a finite resource and water scarcity is increasing globally. For dialysis to be sustainable, a critical need exists for innovative approaches that address the consumption and wastage of water by dialysis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 14, 2020 Category: Urology & Nephrology Authors: John W. M. Agar Katherine A. Barraclough Source Type: research

Nomenclature for kidney function and disease: executive summary from a KDIGO consensus conference
Nature Reviews Nephrology, Published online: 14 May 2020; doi:10.1038/s41581-020-0290-9An obligation of medical journals is the responsible, professional and expeditious delivery of knowledge from researchers and practitioners to the community. The task of editors, therefore, rests not merely in selecting what to publish, but in judging how it might best be communicated. The challenge of improving descriptions of kidney function and disease in medical publishing was the impetus for a KDIGO consensus conference. The conference goals included standardizing and refining kidney-related nomenclature and developing a glossary to...
Source: Nature Reviews Nephrology - May 14, 2020 Category: Urology & Nephrology Authors: Andrew S. Levey Kai-Uwe Eckardt Nijsje M. Dorman Stacy L. Christiansen Michael Cheung Michel Jadoul Wolfgang C. Winkelmayer Source Type: research

CDKL5 controls RTEC fate during AKI
Nature Reviews Nephrology, Published online: 13 May 2020; doi:10.1038/s41581-020-0306-5CDKL5 controls RTEC fate during AKI (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 13, 2020 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Genetics of diabetes mellitus and diabetes complications
Nature Reviews Nephrology, Published online: 12 May 2020; doi:10.1038/s41581-020-0278-5This Review describes advances in genomic analysis that have enabled novel genetic discoveries, more than doubled the number of genetic loci associated with type 2 diabetes mellitus and uncovered several novel candidate genes for diabetes complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 12, 2020 Category: Urology & Nephrology Authors: Joanne B. Cole Jose C. Florez Source Type: research

Using the exposome to address gene–environment interactions in kidney disease
Nature Reviews Nephrology, Published online: 11 May 2020; doi:10.1038/s41581-020-0302-9New exposome-based approaches permit omic-scale characterization of the non-genetic contributors to kidney disease. High-resolution mass spectrometry analysis of plasma and urine samples captures a wide range of exogenous and endogenous metabolites that can be used in combination with genetic risk factors to identify new biomarkers of exposure and therapeutic approaches. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 11, 2020 Category: Urology & Nephrology Authors: Tess V. Dupre Rick G. Schnellmann Gary W. Miller Source Type: research

HIF1α blockade reduces kidney injury in lupus nephritis
Nature Reviews Nephrology, Published online: 07 May 2020; doi:10.1038/s41581-020-0303-8HIF1α blockade reduces kidney injury in lupus nephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 7, 2020 Category: Urology & Nephrology Authors: Joanna Clarke Source Type: research

Innovations in approaches to remove uraemic toxins
Nature Reviews Nephrology, Published online: 07 May 2020; doi:10.1038/s41581-020-0299-0Kidney failure is associated with the retention and subsequent accumulation of uraemic toxins, which have detrimental effects on various physiological processes. The removal of these toxins by current dialysis modalities is inadequate, highlighting the need for innovative approaches to enhance their clearance and/or suppress their generation to improve outcomes for patients with kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 7, 2020 Category: Urology & Nephrology Authors: Rosalinde Masereeuw Marianne C. Verhaar Source Type: research

Targeting inflammation in AKI by P2Y14 receptor inhibition in mice
Nature Reviews Nephrology, Published online: 05 May 2020; doi:10.1038/s41581-020-0300-yTargeting inflammation in AKI by P2Y14 receptor inhibition in mice (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 5, 2020 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Kidney dendritic cells: fundamental biology and functional roles in health and disease
Nature Reviews Nephrology, Published online: 05 May 2020; doi:10.1038/s41581-020-0272-yIn this Review, the authors discuss general dendritic cell biology, including their development, trafficking and functional differentiation. The unique features of kidney dendritic cells are also examined, as well as their role in various acute and chronic types of kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 5, 2020 Category: Urology & Nephrology Authors: Christian Kurts Florent Ginhoux Ulf Panzer Source Type: research

The ethics of genetic testing for kidney diseases
Nature Reviews Nephrology, Published online: 01 May 2020; doi:10.1038/s41581-020-0294-5Growing genomic knowledge has provided immense insight into the aetiology and mechanisms of kidney diseases but raises ethical issues that risk the successful implementation of genomic medicine. We highlight such issues in two contexts: the return of individual genetic results from nephrology research and preimplantation genetic diagnosis for heritable kidney diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 1, 2020 Category: Urology & Nephrology Authors: Maya Sabatello Hila Milo Rasouly Source Type: research

Innovations in dialysis: the user’s perspective
Nature Reviews Nephrology, Published online: 27 April 2020; doi:10.1038/s41581-020-0292-7The need for innovation in dialysis is long overdue. As past and present users of dialysis we are fully aware of the limitations of current dialysis modalities. The time for complacency is over — developers must engage with dialysors to ensure that our needs are met so that we can live the best life possible. Let us share our dream for devices that will enable us to enjoy life. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 27, 2020 Category: Urology & Nephrology Authors: Nieltje Gedney Wim Sipma Henning S øndergaard Source Type: research

SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2
Nature Reviews Nephrology, Published online: 24 April 2020; doi:10.1038/s41581-020-0291-8SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2 (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 24, 2020 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Innovations in dialysis membranes for improved kidney replacement therapy
Nature Reviews Nephrology, Published online: 22 April 2020; doi:10.1038/s41581-020-0293-6Haemodialysis is a life-saving therapy. However, in comparison with the healthy kidney, it removes only a small fraction of the uraemic toxins produced, does not function continuously and cannot replicate biological kidney functions. Innovations in membrane design hold promise to overcome these limitations with potential to improve patient outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 22, 2020 Category: Urology & Nephrology Authors: Ilaria Geremia Dimitrios Stamatialis Source Type: research

The case for evidence-based medicine for the association between hyperuricaemia and CKD
Nature Reviews Nephrology, Published online: 20 April 2020; doi:10.1038/s41581-020-0288-3The case for evidence-based medicine for the association between hyperuricaemia and CKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 20, 2020 Category: Urology & Nephrology Authors: Stefanie Steiger Qiuyue Ma Hans-Joachim Anders Source Type: research

Reply to ‘The case for evidence-based medicine for the association between hyperuricaemia and CKD’
Nature Reviews Nephrology, Published online: 20 April 2020; doi:10.1038/s41581-020-0289-2Reply to ‘The case for evidence-based medicine for the association between hyperuricaemia and CKD’ (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 20, 2020 Category: Urology & Nephrology Authors: Yuka Sato Daniel I. Feig Austin G. Stack Duk-Hee Kang Miguel A. Lanaspa A. Ahsan Ejaz L. Gabriela S ánchez-Lozada Masanari Kuwabara Claudio Borghi Richard J. Johnson Source Type: research

Smart sensors for real-time monitoring of patients on dialysis
Nature Reviews Nephrology, Published online: 17 April 2020; doi:10.1038/s41581-020-0287-4Peritoneal dialysis and haemodialysis are lifesaving but intrusive treatments that are associated with high morbidity and mortality. Despite the considerable time patients with kidney failure spend tied to their life-saving therapies, relatively few vital signs are monitored. Smart, unobtrusive approaches to track clinical parameters could help to individualize treatments and improve patient outcomes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2020 Category: Urology & Nephrology Authors: Fokko P. Wieringa Jeroen P. Kooman Source Type: research

Innovations in peritoneal dialysis
Nature Reviews Nephrology, Published online: 16 April 2020; doi:10.1038/s41581-020-0283-8Peritoneal dialysis (PD) is the dialysis modality of choice for many regions. The application of innovative technology has led to the development of new PD devices that reduce the environmental and economic costs of the therapy, as well as miniaturized devices that provide greater freedom for patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 16, 2020 Category: Urology & Nephrology Authors: Marjorie W. Y. Foo Htay Htay Source Type: research

High-salt diet aggravates pyelonephritis
Nature Reviews Nephrology, Published online: 14 April 2020; doi:10.1038/s41581-020-0285-6High-salt diet aggravates pyelonephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 14, 2020 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Kidney involvement in COVID-19 and rationale for extracorporeal therapies
Nature Reviews Nephrology, Published online: 09 April 2020; doi:10.1038/s41581-020-0284-7The prevalence of direct kidney involvement in novel coronavirus disease (COVID-19) is low, but such involvement is a marker of multiple organ dysfunction and severe disease. Here, we explore potential pathways of kidney damage and discuss the rationale for extracorporeal support with various blood purification strategies in patients who are critically ill with COVID-19. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 9, 2020 Category: Urology & Nephrology Authors: Claudio Ronco Thiago Reis Source Type: research

SuPAR: a potential predictive biomarker for acute kidney injury
Nature Reviews Nephrology, Published online: 08 April 2020; doi:10.1038/s41581-020-0276-7New data suggest that plasma soluble urokinase receptor (suPAR) might be a predictive biomarker and potential therapeutic target for acute kidney injury (AKI). However, many questions remain regarding the potential of suPAR to inform clinical decision making, identify patients for enrolment in clinical trials and add to the understanding of AKI pathogenesis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 8, 2020 Category: Urology & Nephrology Authors: Sarah Faubel Source Type: research

Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy
Nature Reviews Nephrology, Published online: 08 April 2020; doi:10.1038/s41581-020-0267-8This expert Consensus Statement from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup presents recommendations for the management of hyperammonaemia requiring kidney replacement therapy in paediatric populations. Additional studies are needed to strengthen these recommendations, which will be reviewed every 2 years. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 8, 2020 Category: Urology & Nephrology Authors: Rupesh Raina Jirair K. Bedoyan Uta Lichter-Konecki Philippe Jouvet Stefano Picca Nicholas Ah Mew Marcel C. Machado Ronith Chakraborty Meghana Vemuganti Manpreet K. Grewal Timothy Bunchman Sidharth Kumar Sethi Vinod Krishnappa Mignon McCulloch Khalid Alhas Source Type: research

Diagnoses of uncertain significance: kidney genetics in the 21st century
Nature Reviews Nephrology, Published online: 07 April 2020; doi:10.1038/s41581-020-0277-6The increasing availability of sequencing has accelerated the discovery of genetic causes of kidney disease, with clear benefits for patients. However, insufficient or contradictory evidence exists for numerous variants that were previously reported to be pathogenic, calling into question some proposed gene–disease associations. Rigorous re-appraisal of evidence is needed to ensure diagnostic accuracy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 7, 2020 Category: Urology & Nephrology Authors: Daniel P. Gale Andrew Mallett Chirag Patel Tam P. Sneddon Heidi L. Rehm Matthew G. Sampson Detlef Bockenhauer Source Type: research

Genetics of MN
Nature Reviews Nephrology, Published online: 07 April 2020; doi:10.1038/s41581-020-0282-9Genetics of MN (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 7, 2020 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Epigenetic control of inflammatory cells
Nature Reviews Nephrology, Published online: 06 April 2020; doi:10.1038/s41581-020-0281-xEpigenetic control of inflammatory cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 6, 2020 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Minimizing the risk of COVID-19 among patients on dialysis
Nature Reviews Nephrology, Published online: 06 April 2020; doi:10.1038/s41581-020-0280-yPatients on haemodialysis or peritoneal dialysis are likely to be at increased risk of novel coronavirus disease (COVID-19). Preventive strategies must be implemented to minimize the risk of disease transmission in dialysis facilities, including education of staff and patients, screening for COVID-19 and separation of infected or symptomatic and non-infected patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 6, 2020 Category: Urology & Nephrology Authors: T. Alp Ikizler Alan S. Kliger Source Type: research

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic
Nature Reviews Nephrology, Published online: 03 April 2020; doi:10.1038/s41581-020-0279-4The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 3, 2020 Category: Urology & Nephrology Authors: Andrew M. South Laurie Tomlinson Daniel Edmonston Swapnil Hiremath Matthew A. Sparks Source Type: research

Regulatory approaches to stimulate innovative renal replacement therapies
Nature Reviews Nephrology, Published online: 02 April 2020; doi:10.1038/s41581-020-0275-8Regulations for market access and reimbursement of medical devices vary across jurisdictions, complicating the development of innovative technologies for world-wide use; however, several converging regulatory principles are now emerging. Here we discuss approaches by which regulatory and related agencies can promote innovation and boost the effectiveness of regulatory processes to expedite patient access to innovative technologies, including renal replacement therapies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 2, 2020 Category: Urology & Nephrology Authors: Fokko P. Wieringa Murray I. Sheldon Ana Hidalgo-Simon Source Type: research

eHealth in kidney care
Nature Reviews Nephrology, Published online: 01 April 2020; doi:10.1038/s41581-020-0271-zeHealth is gaining momentum in nephrology, although evidence for its efficacy remains unclear and challenges to its widespread adoption persist. Successful integration of eHealth into kidney care will require patient engagement to develop effective interventions and issues such as data validity, regulation, oversight and adequate infrastructure to be addressed. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 1, 2020 Category: Urology & Nephrology Authors: Chia-shi Wang Elaine Ku Source Type: research

The (pro)renin receptor: what’s in a name?
Nature Reviews Nephrology, Published online: 01 April 2020; doi:10.1038/s41581-020-0274-9The (pro)renin receptor: what’s in a name? (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 1, 2020 Category: Urology & Nephrology Authors: Matias Simons Michael Bader Dominik N. M üller Source Type: research

Mechanisms of cognitive dysfunction in CKD
Nature Reviews Nephrology, Published online: 31 March 2020; doi:10.1038/s41581-020-0266-9Capasso and colleagues provide an overview of cognitive dysfunction resulting from CKD, including mild cognitive impairment and dementia. CKD-associated cognitive impairment seems to be caused by the effects of uraemic neurotoxins and kidney neurotrophins on specific neurons and regions of the brain. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 31, 2020 Category: Urology & Nephrology Authors: Davide Viggiano Carsten A. Wagner Gianvito Martino Maiken Nedergaard Carmine Zoccali Robert Unwin Giovambattista Capasso Source Type: research

mGWAS: next generation genetic prediction in kidney disease
Nature Reviews Nephrology, Published online: 30 March 2020; doi:10.1038/s41581-020-0270-0A recent metabolite genome-wide association study (mGWAS) investigated the relationship between genetic factors and the urine metabolome in kidney disease. The findings demonstrate that mGWAS hold promise for identifying novel genetic factors involved in adsorption, distribution, metabolism and excretion of metabolites and pharmaceuticals, as well as biomarkers for disease progression. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 30, 2020 Category: Urology & Nephrology Authors: Daniel Montemayor Kumar Sharma Source Type: research

Tools for the analysis of high-dimensional single-cell RNA sequencing data
Nature Reviews Nephrology, Published online: 27 March 2020; doi:10.1038/s41581-020-0262-0This Review provides the non-expert reader with an overview of the different steps involved in the analysis of single-cell RNA sequencing data. The authors also provide insight into the strengths and pitfalls of available analysis tools. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 27, 2020 Category: Urology & Nephrology Authors: Yan Wu Kun Zhang Source Type: research

Claudin 2: role in hypercalciuria and kidney stone disease
Nature Reviews Nephrology, Published online: 24 March 2020; doi:10.1038/s41581-020-0273-xClaudin 2: role in hypercalciuria and kidney stone disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 24, 2020 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

PEXIVAS challenges current ANCA-associated vasculitis therapy
Nature Reviews Nephrology, Published online: 13 March 2020; doi:10.1038/s41581-020-0269-6The PEXIVAS clinical trial demonstrated that, in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV), adjuvant plasma exchange did not reduce the risk of all-cause mortality or end-stage kidney disease and a reduced dose of glucocorticoids was not inferior to standard dosing. These findings might warrant a change in standard AAV therapy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 13, 2020 Category: Urology & Nephrology Authors: Adam Morris Duvuru Geetha Source Type: research

The evolving role of TonEBP as an immunometabolic stress protein
Nature Reviews Nephrology, Published online: 10 March 2020; doi:10.1038/s41581-020-0261-1TonEBP is a DNA-binding protein with multiple roles, via transcription regulation and other mechanisms, in both protective and pathological responses to stress. In this Review, Kwon and colleagues discuss these multiple roles in various stress responses. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 10, 2020 Category: Urology & Nephrology Authors: Soo Youn Choi Whaseon Lee-Kwon Hyug Moo Kwon Source Type: research

The tubular hypothesis of nephron filtration and diabetic kidney disease
Nature Reviews Nephrology, Published online: 09 March 2020; doi:10.1038/s41581-020-0256-yVallon and Thompson provide a tubule-centred view of diabetic kidney physiology. According to the tubular hypothesis of nephron filtration and diabetic kidney disease, early diabetes induces changes in renal tubules that alter interactions between the tubule and glomerulus, ultimately leading to diabetic kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 9, 2020 Category: Urology & Nephrology Authors: Volker Vallon Scott C. Thomson Source Type: research

Targeting angiogenesis and lymphangiogenesis in kidney disease
Nature Reviews Nephrology, Published online: 06 March 2020; doi:10.1038/s41581-020-0260-2In this Review, the authors discuss current understanding of the expression and dysregulation of factors that regulate angiogenesis and lymphangiogenesis in the kidney, as well as potential therapeutic strategies to target these factors during various kidney diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 6, 2020 Category: Urology & Nephrology Authors: Katsuyuki Tanabe Jun Wada Yasufumi Sato Source Type: research

The impact of chronic kidney disease on global health
Nature Reviews Nephrology, Published online: 06 March 2020; doi:10.1038/s41581-020-0268-7The impact of chronic kidney disease on global health (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 6, 2020 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Sensing of tubular flow and renal electrolyte transport
Nature Reviews Nephrology, Published online: 03 March 2020; doi:10.1038/s41581-020-0259-8The kidneys are essential for water and electrolyte homeostasis. This Review outlines the effect of tubular flow on renal electrolyte transport along the nephron and the current challenges in the emerging field of tubular flow dynamics in the kidney. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 3, 2020 Category: Urology & Nephrology Authors: Eric H. J. Verschuren Charlotte Castenmiller Dorien J. M. Peters Francisco J. Arjona Ren é J. M. Bindels Joost G. J. Hoenderop Source Type: research

Kidney metabolite induces FGF23 rise
Nature Reviews Nephrology, Published online: 02 March 2020; doi:10.1038/s41581-020-0265-xKidney metabolite induces FGF23 rise (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 2, 2020 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

New insights into the obesity paradox in renal cell carcinoma
Nature Reviews Nephrology, Published online: 02 March 2020; doi:10.1038/s41581-020-0264-yParadoxically, elevated BMI is a recognized positive prognostic factor in renal cell carcinoma (RCC). A recent investigation of the transcriptomic signatures of RCC tumours and peritumoural tissues suggests potential biological mechanisms underlying this effect. However, the clinical utility of BMI in the context of RCC remains uncertain. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 2, 2020 Category: Urology & Nephrology Authors: Chun Loo Gan Daniel Y. C. Heng Source Type: research

Bacterial infection linked to anti-factor B antibodies
Nature Reviews Nephrology, Published online: 25 February 2020; doi:10.1038/s41581-020-0263-zBacterial infection linked to anti-factor B antibodies (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 25, 2020 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Targeting the progression of chronic kidney disease
Nature Reviews Nephrology, Published online: 14 February 2020; doi:10.1038/s41581-019-0248-yHere, the authors review drivers of fibrogenesis, including epithelial cell injury, inflammation, regeneration pathways and factors that promote the AKI-to-CKD transition. They discuss direct targeting of fibrotic pathways and therapeutic approaches that have reportedly decreased kidney fibrosis in preclinical and/or clinical studies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 14, 2020 Category: Urology & Nephrology Authors: Marta Ruiz-Ortega Sandra Rayego-Mateos Santiago Lamas Alberto Ortiz Raul R. Rodrigues-Diez Source Type: research

Long-term outcomes of acute kidney injury and strategies for improved care
Nature Reviews Nephrology, Published online: 12 February 2020; doi:10.1038/s41581-019-0247-zAn episode of acute kidney injury (AKI) can predispose individuals to a variety of adverse clinical outcomes. In this Review, the authors discuss the potential long-term outcomes of AKI, as well as current and novel strategies to improve the follow-up care of AKI survivors. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 12, 2020 Category: Urology & Nephrology Authors: Matthew T. James Meha Bhatt Neesh Pannu Marcello Tonelli Source Type: research

Kidney sphere grafts for tissue regeneration
Nature Reviews Nephrology, Published online: 11 February 2020; doi:10.1038/s41581-020-0258-9Kidney sphere grafts for tissue regeneration (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 11, 2020 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Pharmacokinetic modelling using linked organ chips
Nature Reviews Nephrology, Published online: 10 February 2020; doi:10.1038/s41581-020-0257-xPharmacokinetic modelling using linked organ chips (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 10, 2020 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Green nephrology
Nature Reviews Nephrology, Published online: 07 February 2020; doi:10.1038/s41581-019-0245-1Here, the authors outline the relationship between environmental change and kidney diseases and discuss the environmental impact of kidney care delivery, focusing on dialysis. They highlight existing opportunities to reduce the carbon footprint of nephrology, as well as areas for future research. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 7, 2020 Category: Urology & Nephrology Authors: Katherine A. Barraclough John W. M. Agar Source Type: research

The global epidemiology of hypertension
Nature Reviews Nephrology, Published online: 05 February 2020; doi:10.1038/s41581-019-0244-2Hypertension is the leading global cause of cardiovascular disease and premature mortality. In this Review, the authors describe the prevalence, awareness, treatment and control of hypertension worldwide, as well as risk factors for hypertension and the financial burden of this disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 5, 2020 Category: Urology & Nephrology Authors: Katherine T. Mills Andrei Stefanescu Jiang He Source Type: research