Cardiorenal complications of immune checkpoint inhibitors
Cardiorenal complications of immune checkpoint inhibitors, Published online: 16 July 2018; doi:10.1038/s41581-018-0035-1Immune checkpoint inhibitors (ICIs) have led to a paradigm shift in cancer therapy; however, these agents can induce immune-related adverse events (irAEs) in off-target organs. This Review describes the mechanism of action of ICI therapies and how these agents induce irAEs in the kidney and heart. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 16, 2018 Category: Urology & Nephrology Authors: Krishna Sury Mark A. Perazella Anushree C. Shirali Source Type: research

Pivotal role of CaMK4 in podocyte injury
Pivotal role of CaMK4 in podocyte injury, Published online: 11 July 2018; doi:10.1038/s41581-018-0042-2Pivotal role of CaMK4 in podocyte injury (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 11, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Hedgehog–TGFβ signalling controls nephrogenesis
Hedgehog–TGFβ signalling controls nephrogenesisHedgehog–TGFβ signalling controls nephrogenesis, Published online: 11 July 2018; doi:10.1038/s41581-018-0043-1Hedgehog–TGFβ signalling controls nephrogenesis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 11, 2018 Category: Urology & Nephrology Authors: Grant Otto Source Type: research

HLA in transplantation
HLA in transplantation, Published online: 09 July 2018; doi:10.1038/s41581-018-0039-xImproved understanding of HLAs together with advances in HLA typing and antibody detection techniques have enabled transplantation of sensitized patients. Here, the authors discuss these advances as well as novel approaches to desensitization, immunomodulation and tolerance induction. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 9, 2018 Category: Urology & Nephrology Authors: Robert A. Montgomery Vasishta S. Tatapudi Mary S. Leffell Andrea A. Zachary Source Type: research

Renal denervation: one step backwards, three steps forward
Renal denervation: one step backwards, three steps forward, Published online: 06 July 2018; doi:10.1038/s41581-018-0040-4Many considered the failure of the SYMPLICITY HTN-3 trial to represent the end of therapeutic renal denervation. However, promising preliminary data from the SPYRAL HTN-OFF MED study and more recently the SPYRAL HTN-ON MED and RADIANCE-HTN SOLO studies support the efficacy of this intervention for blood pressure lowering in patients with hypertension. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 6, 2018 Category: Urology & Nephrology Authors: Markus P. Schlaich George L. Bakris Source Type: research

The role of nephrectomy in metastatic renal cell carcinoma
The role of nephrectomy in metastatic renal cell carcinoma, Published online: 04 July 2018; doi:10.1038/s41581-018-0041-3Cytoreductive nephrectomy is the current treatment paradigm for metastatic renal cell carcinoma (RCC). However, the introduction of targeted therapies has dramatically changed the treatment landscape and may limit the role of nephrectomy in this disease. The recent CARMENA trial supports initial medical treatment of patients with RCC and synchronous metastases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 4, 2018 Category: Urology & Nephrology Authors: Viktor Gr ünwald Axel Bex Source Type: research

The role of B7-1 in proteinuria of glomerular origin
The role of B7-1 in proteinuria of glomerular origin, Published online: 29 June 2018; doi:10.1038/s41581-018-0037-zThis Perspectives article describes supporting and contradicting data regarding the role of podocyte B7-1 in the pathogenesis of various podocytopathies and highlights issues that need to be addressed to standardize approaches to the study of this protein. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 29, 2018 Category: Urology & Nephrology Authors: Rubina Novelli Ariela Benigni Giuseppe Remuzzi Source Type: research

Targeting ARNT to attenuate renal fibrosis
Targeting ARNT to attenuate renal fibrosis, Published online: 28 June 2018; doi:10.1038/s41581-018-0038-yTargeting ARNT to attenuate renal fibrosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 28, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Pericytes in the renal vasculature: roles in health and disease
Pericytes in the renal vasculature: roles in health and disease, Published online: 25 June 2018; doi:10.1038/s41581-018-0032-4Renal pericytes have important roles in kidney development, blood pressure regulation and the pathogenesis of kidney disease. Here, the authors review the embryonic development, adult tissue distribution and physiological and pathological roles of the various pericyte subsets in the kidney. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 25, 2018 Category: Urology & Nephrology Authors: Isaac Shaw Sebastien Rider John Mullins Jeremy Hughes Bruno P éault Source Type: research

Immune networks in CI-AKI
Immune networks in CI-AKI, Published online: 19 June 2018; doi:10.1038/s41581-018-0036-0Immune networks in CI-AKI (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 19, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Preserving kidney health during intensive blood pressure control
Preserving kidney health during intensive blood pressure control, Published online: 13 June 2018; doi:10.1038/s41581-018-0034-2Intensive lowering of blood pressure can decrease the risk of death and cardiovascular events in individuals with hypertension. However, a reanalysis of data from the SPRINT and ACCORD trials suggests that intensive blood pressure lowering increases the risk of chronic kidney disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 13, 2018 Category: Urology & Nephrology Authors: Maria Luisa S. Sequeira-Lopez R. Ariel Gomez Source Type: research

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases, Published online: 12 June 2018; doi:10.1038/s41581-018-0023-5Mesenchymal stem or stromal cells (MSCs) have attracted much attention for their ability to regulate inflammatory processes. Here, Shi et al. discuss current understanding of the immunomodulatory mechanisms of MSCs and issues related to their therapeutic application. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 12, 2018 Category: Urology & Nephrology Authors: Yufang Shi Yu Wang Qing Li Keli Liu Jianquan Hou Changshun Shao Ying Wang Source Type: research

Adverse effects of SGLT2 inhibitors on bone health
Adverse effects of SGLT2 inhibitors on bone health, Published online: 06 June 2018; doi:10.1038/s41581-018-0028-0Sodium–glucose cotransporter 2 (SGLT2) inhibitors provide metabolic and cardiorenal benefits for patients with type 2 diabetes but are associated with a number of safety issues. Here, we discuss evidence suggesting that indirect activation of the FGF23–1,25-dihydroxyvitamin D–parathyroid hormone axis by SGLT2 inhibition might contribute to adverse effects on bone health. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2018 Category: Urology & Nephrology Authors: Jenny E. Blau Simeon I. Taylor Source Type: research

The origin, evolution and route to metastasis of clear cell RCC
The origin, evolution and route to metastasis of clear cell RCC, Published online: 06 June 2018; doi:10.1038/s41581-018-0031-5Three reports from the TRACERx Renal study delineate the precise origin and evolution of clear cell renal cell carcinoma in minute detail. The insights gained from these studies might provide improved disease prognostics and identify novel therapeutic targets. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2018 Category: Urology & Nephrology Authors: Christopher J. Ricketts W. Marston Linehan Source Type: research

Regulation of nephrogenesis
Regulation of nephrogenesis, Published online: 06 June 2018; doi:10.1038/s41581-018-0033-3Regulation of nephrogenesis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 6, 2018 Category: Urology & Nephrology Authors: Ellen Carney Source Type: research

RHO-like GTPases in nephrotic syndrome
RHO-like GTPases in nephrotic syndrome, Published online: 31 May 2018; doi:10.1038/s41581-018-0030-6RHO-like GTPases in nephrotic syndrome (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 31, 2018 Category: Urology & Nephrology Authors: Grant Otto Source Type: research

Cancer in kidney transplant recipients
Cancer in kidney transplant recipients, Published online: 25 May 2018; doi:10.1038/s41581-018-0022-6Kidney transplant recipients have an increased risk of developing de novo or recurrent cancer compared with age-matched and gender-matched individuals from the general population. Here, Au et al. describe the epidemiology and outcomes of cancers in transplant recipients and discuss approaches to reduce cancer prevalence as well as post-transplantation cancer management, including approaches for modulating immunosuppression. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 25, 2018 Category: Urology & Nephrology Authors: Eric Au Germaine Wong Jeremy R. Chapman Source Type: research

AhR in SLE
AhR in SLE, Published online: 25 May 2018; doi:10.1038/s41581-018-0027-1AhR in SLE (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 25, 2018 Category: Urology & Nephrology Authors: Joanna Collison Source Type: research

IL-1β switches on kidney fibrosis
IL-1β switches on kidney fibrosisIL-1β switches on kidney fibrosis, Published online: 24 May 2018; doi:10.1038/s41581-018-0026-2IL-1β switches on kidney fibrosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 24, 2018 Category: Urology & Nephrology Authors: Grant Otto Source Type: research

Altered ammonia metabolism in ccRCC
Altered ammonia metabolism in ccRCC, Published online: 24 May 2018; doi:10.1038/s41581-018-0029-zAltered ammonia metabolism in ccRCC (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 24, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

FGF21 ACEs hypertension
FGF21 ACEs hypertension, Published online: 23 May 2018; doi:10.1038/s41581-018-0020-8FGF21 ACEs hypertension (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 23, 2018 Category: Urology & Nephrology Authors: Grant Otto Source Type: research

Renal IL-17 activity in candidiasis
Renal IL-17 activity in candidiasis, Published online: 22 May 2018; doi:10.1038/s41581-018-0025-3Renal IL-17 activity in candidiasis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 22, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Single-cell RNA sequencing for the study of development, physiology and disease
Single-cell RNA sequencing for the study of development, physiology and disease, Published online: 22 May 2018; doi:10.1038/s41581-018-0021-7Technological advances are providing unprecedented opportunities to analyse biological systems at the single-cell level. This Review describes the fundamental concepts of single-cell RNA analysis and specific applications of the technology for the study of development, cancer and normal and diseased kidneys. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 22, 2018 Category: Urology & Nephrology Authors: S. Steven Potter Source Type: research

DNAJB11: another player in ADPKD
DNAJB11: another player in ADPKD, Published online: 18 May 2018; doi:10.1038/s41581-018-0024-4DNAJB11: another player in ADPKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 18, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney diseaseThe gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease, Published online: 14 May 2018; doi:10.1038/s41581-018-0018-2Increasing evidence suggests an important role of the gut microbiota in the development of hypertension and chronic kidney disease. In this Review, the authors explain their brain–gut–kidney axis hypothesis for the pathogenesis of these diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 14, 2018 Category: Urology & Nephrology Authors: Tao Yang Elaine M. Richards Carl J. Pepine Mohan K. Raizada Source Type: research

The role of platelets in acute kidney injury
The role of platelets in acute kidney injury, Published online: 14 May 2018; doi:10.1038/s41581-018-0015-5Acute kidney injury (AKI) is characterized by the activation of intra-renal haemostatic and inflammatory processes. Here, the authors discuss the role of platelets as modulators of inflammation and haemostasis at the site of vascular injury, their interactions with endothelial cells and leukocytes and current antiplatelet strategies in AKI. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 14, 2018 Category: Urology & Nephrology Authors: Marcel P. B. Jansen Sandrine Florquin Joris J. T. H. Roelofs Source Type: research

GWAS highlights challenges associated with identification of DKD risk variants
GWAS highlights challenges associated with identification of DKD risk variants, Published online: 11 May 2018; doi:10.1038/s41581-018-0019-1GWAS highlights challenges associated with identification of DKD risk variants (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 11, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Haemodialysis membranes
Haemodialysis membranes, Published online: 05 May 2018; doi:10.1038/s41581-018-0002-xHaemodialysis membranes are traditionally classified on the basis of their composition and water permeability. In this Review, the authors discuss the advances in materials technology, polymer chemistry, surface functionalization and dialyser assembly that mandate new classification approaches. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 5, 2018 Category: Urology & Nephrology Authors: Claudio Ronco William R. Clark Source Type: research

Cellular recording devices imprint the history of the cell
Cellular recording devices imprint the history of the cell, Published online: 01 May 2018; doi:10.1038/s41581-018-0012-8Technologies such as proteomics provide a snapshot of a specific cellular state but are unable to directly record successive signalling events. Two new CRISPR-mediated analogue multi-event recording apparatus (CAMERA) systems enable sequential recording of endogenous and exogenous signalling events by targeted DNA modifications, thereby allowing systematic interrogation of different cellular states. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 1, 2018 Category: Urology & Nephrology Authors: Nicholas J. Steers Ali G. Gharavi Source Type: research

Subclassification of diabetes based on quantitative traits
Subclassification of diabetes based on quantitative traits, Published online: 01 May 2018; doi:10.1038/s41581-018-0011-9A new subclassification of diabetes based on quantitative traits, including age, body mass index, insulin resistance and β-cell function suggests five clusters with distinct phenotypes and prognoses. This approach may offer a novel way to classify diabetes by providing more information on risks and potential therapeutic strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 1, 2018 Category: Urology & Nephrology Authors: Peter Rossing Source Type: research

Rethinking progression of CKD as a process of punctuated equilibrium
Rethinking progression of CKD as a process of punctuated equilibrium, Published online: 01 May 2018; doi:10.1038/s41581-018-0016-4Although most nephrologists spend their days managing patients with acute and chronic kidney disease (CKD), it is useful to occasionally consider the landscape of our current treatment approach. Here, we present the hypothesis that the major mechanisms that drive CKD are changing and will necessitate new approaches to manage this disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 1, 2018 Category: Urology & Nephrology Authors: Richard J. Johnson Bernardo Rodriguez-Iturbe Source Type: research

Diagnosis and management of resistant hypertension: state of the art
Diagnosis and management of resistant hypertension: state of the art, Published online: 26 April 2018; doi:10.1038/s41581-018-0006-6In this Review, the authors discuss the epidemiology, diagnosis and optimal management of resistant hypertension. They highlight the limitations of clinical trials of device-based therapies conducted to date and propose directions for future research. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 26, 2018 Category: Urology & Nephrology Authors: Fang-Fei Wei Zhen-Yu Zhang Qi-Fang Huang Jan A. Staessen Source Type: research

Is ciliary Hedgehog signalling dispensable in the kidneys?
Is ciliary Hedgehog signalling dispensable in the kidneys?, Published online: 26 April 2018; doi:10.1038/s41581-018-0014-6An unbiased functional gene knockout screen to identify genes implicated in Hedgehog signalling in primary cilia detected most components of the ciliary machinery and ciliopathy-associated genes, but no kidney-related ciliopathy genes. The 472 hits are a tremendous resource for identifying potential ciliopathy genes and for analysing ciliary function and signalling pathways. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 26, 2018 Category: Urology & Nephrology Authors: Edgar A. Otto Source Type: research

Whole-kidney single-cell transcriptomics identifies new cell types
Whole-kidney single-cell transcriptomics identifies new cell types, Published online: 25 April 2018; doi:10.1038/s41581-018-0013-7Whole-kidney single-cell transcriptomics identifies new cell types (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 25, 2018 Category: Urology & Nephrology Authors: Jack M. Heintze Source Type: research

GATM mutations cause mitochondrial abnormalities and kidney failure
GATM mutations cause mitochondrial abnormalities and kidney failure, Published online: 25 April 2018; doi:10.1038/s41581-018-0017-3GATM mutations cause mitochondrial abnormalities and kidney failure (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 25, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Mechanisms and treatment of organ failure in sepsis
Mechanisms and treatment of organ failure in sepsis, Published online: 24 April 2018; doi:10.1038/s41581-018-0005-7Dysfunction of one or more organs is a common occurrence in patients with sepsis owing to microcirculatory alterations and cellular dysfunction. In this Review, the authors summarize knowledge of the mechanisms that underlie organ failure in sepsis and discuss how these insights are providing targets for the treatment of sepsis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 24, 2018 Category: Urology & Nephrology Authors: Christophe Lelubre Jean-Louis Vincent Source Type: research

Intu protects the kidney
Intu protects the kidney , Published online: 17 April 2018; doi:10.1038/s41581-018-0010-x Intu protects the kidney (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Abnormal saline and the history of intravenous fluids
Abnormal saline and the history of intravenous fluids, Published online: 13 April 2018; doi:10.1038/s41581-018-0008-4Two new clinical trials together involving nearly 30,000 patients support previous observational evidence that the most common solution used for intravenous fluid therapy in the world is associated with kidney damage. Both trials found that 0.9% saline was inferior to solutions with more physiological chloride concentrations and resulted in greater rates of major adverse kidney events. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 13, 2018 Category: Urology & Nephrology Authors: John A. Kellum Source Type: research

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease, Published online: 13 April 2018; doi:10.1038/s41581-018-0001-yPatients who present with chronic kidney disease and diabetes mellitus can have true diabetic kidney disease (DKD), nondiabetic kidney disease (NDKD), or a combination of both DKD and NDKD. Here, Anders and colleagues discuss the mechanisms underlying these entities and how greater appreciation of distinctions between these entities might facilitate the development of new treatments. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 13, 2018 Category: Urology & Nephrology Authors: Hans-Joachim Anders Tobias B. Huber Berend Isermann Mario Schiffer Source Type: research

Implantable cardioverter defibrillators in chronic kidney disease
Implantable cardioverter defibrillators in chronic kidney disease, Published online: 12 April 2018; doi:10.1038/s41581-018-0007-5A recent observational study reports that implantable cardioverter defibrillators were not associated with improved survival in patients with heart failure, reduced left ventricular ejection fraction and chronic kidney disease. Further studies are needed to identify which of these high-risk patients are most likely to benefit from this potentially life-saving therapy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 12, 2018 Category: Urology & Nephrology Authors: Finnian R. Mc Causland Marc A. Pfeffer Source Type: research

Osteopontin drives renal metabolic dysfunction in Alport syndrome
Osteopontin drives renal metabolic dysfunction in Alport syndrome, Published online: 11 April 2018; doi:10.1038/s41581-018-0009-3Osteopontin drives renal metabolic dysfunction in Alport syndrome (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 11, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Genetics: An integrated genetic analysis of disease
Genetics: An integrated genetic analysis of disease, Published online: 09 April 2018; doi:10.1038/nrneph.2018.26A genome-wide association study (GWAS) of quantitative traits that incorporated data from GWAS of complex diseases provides clues regarding the relationships between genetic loci, intermediate phenotypes and diseases. Together, the data demonstrate pleiotropy, genetic correlation and cell-type specificity of quantitative traits as predictors of multiple complex diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 9, 2018 Category: Urology & Nephrology Authors: David L. Mattson Source Type: research

Advances in predictive in vitro models of drug-induced nephrotoxicity
Advances in predictive in vitro models of drug-induced nephrotoxicity, Published online: 06 April 2018; doi:10.1038/s41581-018-0003-9Current in vitro nephrotoxicity screens are poorly predictive of toxicity in humans. Here, the authors describe mechanisms of nephrotoxic injury, the functional features of tubular cell models that are essential for predicting the toxicity of pharmaceutical compounds, and novel in vitro cell models under development. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 6, 2018 Category: Urology & Nephrology Authors: Joanne Y.-C. Soo Jitske Jansen Rosalinde Masereeuw Melissa H. Little Source Type: research

A neutrophil motility assay for early diagnosis of sepsis
A neutrophil motility assay for early diagnosis of sepsis, Published online: 29 March 2018; doi:10.1038/s41581-018-0004-8A neutrophil motility assay for early diagnosis of sepsis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 29, 2018 Category: Urology & Nephrology Authors: Jack M. Heintze Source Type: research

Epidemiology: Chronic disease, cancer, and exercise — a common link
Epidemiology: Chronic disease, cancer, and exercise — a common linkEpidemiology: Chronic disease, cancer, and exercise — a common link, Published online: 26 March 2018; doi:10.1038/nrneph.2018.24Advances in precision medicine have greatly improved outcomes for patients with cancer. New findings that demonstrate a substantial contribution of major chronic diseases and disease markers to the risk of cancer incidence and mortality highlight the impact of chronic disease on cancer risk and suggest that chronic diseases should be targeted in cancer prevention strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Andrew S. Allegretti Ravi I. Thadhani Source Type: research

Metabolism: High salt intake as a driver of obesity
Metabolism: High salt intake as a driver of obesity, Published online: 26 March 2018; doi:10.1038/nrneph.2018.23Metabolism: High salt intake as a driver of obesity (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Use of oral anticoagulants in patients with atrial fibrillation and renal dysfunction
Use of oral anticoagulants in patients with atrial fibrillation and renal dysfunctionUse of oral anticoagulants in patients with atrial fibrillation and renal dysfunction, Published online: 26 March 2018; doi:10.1038/nrneph.2018.19Renal dysfunction and atrial fibrillation (AF) share common risk factors and often coexist. Here, the authors discuss the risks and benefits of use of vitamin K antagonists (VKAs) and non-VKA oral anticoagulants for thromboprophylaxis in patients with coexistent AF and renal dysfunction. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Tatjana S. Potpara Charles J. Ferro Gregory Y. H. Lip Source Type: research

Angiotensin-converting enzyme in innate and adaptive immunity
Angiotensin-converting enzyme in innate and adaptive immunity, Published online: 26 March 2018; doi:10.1038/nrneph.2018.15Angiotensin-converting enzyme (ACE) not only plays a major part in the regulation of blood pressure but also participates in several other physiological functions, including renal development and male reproduction. Here, Bernstein et al. discuss how ACE enhances both innate and adaptive responses by modulating macrophage and neutrophil function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Kenneth E. Bernstein Zakir Khan Jorge F. Giani Duo-Yao Cao Ellen A. Bernstein Xiao Z. Shen Source Type: research

Autoimmunity: IL-17C promotes immune-mediated glomerular disease
Autoimmunity: IL-17C promotes immune-mediated glomerular disease, Published online: 19 March 2018; doi:10.1038/nrneph.2018.22Autoimmunity: IL-17C promotes immune-mediated glomerular disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 19, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Autoimmunity: Increased PGD2 signalling in lupus pathogenesis
Autoimmunity: Increased PGD2 signalling in lupus pathogenesis, Published online: 12 March 2018; doi:10.1038/nrneph.2018.21Autoimmunity: Increased PGD2 signalling in lupus pathogenesis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 12, 2018 Category: Urology & Nephrology Authors: Jack M. Heintze Source Type: research