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Intu protects the kidney
Intu protects the kidney , Published online: 17 April 2018; doi:10.1038/s41581-018-0010-x Intu protects the kidney (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Abnormal saline and the history of intravenous fluids
Abnormal saline and the history of intravenous fluids, Published online: 13 April 2018; doi:10.1038/s41581-018-0008-4Two new clinical trials together involving nearly 30,000 patients support previous observational evidence that the most common solution used for intravenous fluid therapy in the world is associated with kidney damage. Both trials found that 0.9% saline was inferior to solutions with more physiological chloride concentrations and resulted in greater rates of major adverse kidney events. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 13, 2018 Category: Urology & Nephrology Authors: John A. Kellum Source Type: research

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease, Published online: 13 April 2018; doi:10.1038/s41581-018-0001-yPatients who present with chronic kidney disease and diabetes mellitus can have true diabetic kidney disease (DKD), nondiabetic kidney disease (NDKD), or a combination of both DKD and NDKD. Here, Anders and colleagues discuss the mechanisms underlying these entities and how greater appreciation of distinctions between these entities might facilitate the development of new treatments. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 13, 2018 Category: Urology & Nephrology Authors: Hans-Joachim Anders Tobias B. Huber Berend Isermann Mario Schiffer Source Type: research

Implantable cardioverter defibrillators in chronic kidney disease
Implantable cardioverter defibrillators in chronic kidney disease, Published online: 12 April 2018; doi:10.1038/s41581-018-0007-5A recent observational study reports that implantable cardioverter defibrillators were not associated with improved survival in patients with heart failure, reduced left ventricular ejection fraction and chronic kidney disease. Further studies are needed to identify which of these high-risk patients are most likely to benefit from this potentially life-saving therapy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 12, 2018 Category: Urology & Nephrology Authors: Finnian R. Mc Causland Marc A. Pfeffer Source Type: research

Osteopontin drives renal metabolic dysfunction in Alport syndrome
Osteopontin drives renal metabolic dysfunction in Alport syndrome, Published online: 11 April 2018; doi:10.1038/s41581-018-0009-3Osteopontin drives renal metabolic dysfunction in Alport syndrome (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 11, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Genetics: An integrated genetic analysis of disease
Genetics: An integrated genetic analysis of disease, Published online: 09 April 2018; doi:10.1038/nrneph.2018.26A genome-wide association study (GWAS) of quantitative traits that incorporated data from GWAS of complex diseases provides clues regarding the relationships between genetic loci, intermediate phenotypes and diseases. Together, the data demonstrate pleiotropy, genetic correlation and cell-type specificity of quantitative traits as predictors of multiple complex diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 9, 2018 Category: Urology & Nephrology Authors: David L. Mattson Source Type: research

Advances in predictive in vitro models of drug-induced nephrotoxicity
Advances in predictive in vitro models of drug-induced nephrotoxicity, Published online: 06 April 2018; doi:10.1038/s41581-018-0003-9Current in vitro nephrotoxicity screens are poorly predictive of toxicity in humans. Here, the authors describe mechanisms of nephrotoxic injury, the functional features of tubular cell models that are essential for predicting the toxicity of pharmaceutical compounds, and novel in vitro cell models under development. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 6, 2018 Category: Urology & Nephrology Authors: Joanne Y.-C. Soo Jitske Jansen Rosalinde Masereeuw Melissa H. Little Source Type: research

A neutrophil motility assay for early diagnosis of sepsis
A neutrophil motility assay for early diagnosis of sepsis, Published online: 29 March 2018; doi:10.1038/s41581-018-0004-8A neutrophil motility assay for early diagnosis of sepsis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 29, 2018 Category: Urology & Nephrology Authors: Jack M. Heintze Source Type: research

Epidemiology: Chronic disease, cancer, and exercise — a common link
Epidemiology: Chronic disease, cancer, and exercise — a common linkEpidemiology: Chronic disease, cancer, and exercise — a common link, Published online: 26 March 2018; doi:10.1038/nrneph.2018.24Advances in precision medicine have greatly improved outcomes for patients with cancer. New findings that demonstrate a substantial contribution of major chronic diseases and disease markers to the risk of cancer incidence and mortality highlight the impact of chronic disease on cancer risk and suggest that chronic diseases should be targeted in cancer prevention strategies. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Andrew S. Allegretti Ravi I. Thadhani Source Type: research

Metabolism: High salt intake as a driver of obesity
Metabolism: High salt intake as a driver of obesity, Published online: 26 March 2018; doi:10.1038/nrneph.2018.23Metabolism: High salt intake as a driver of obesity (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Use of oral anticoagulants in patients with atrial fibrillation and renal dysfunction
Use of oral anticoagulants in patients with atrial fibrillation and renal dysfunctionUse of oral anticoagulants in patients with atrial fibrillation and renal dysfunction, Published online: 26 March 2018; doi:10.1038/nrneph.2018.19Renal dysfunction and atrial fibrillation (AF) share common risk factors and often coexist. Here, the authors discuss the risks and benefits of use of vitamin K antagonists (VKAs) and non-VKA oral anticoagulants for thromboprophylaxis in patients with coexistent AF and renal dysfunction. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Tatjana S. Potpara Charles J. Ferro Gregory Y. H. Lip Source Type: research

Angiotensin-converting enzyme in innate and adaptive immunity
Angiotensin-converting enzyme in innate and adaptive immunity, Published online: 26 March 2018; doi:10.1038/nrneph.2018.15Angiotensin-converting enzyme (ACE) not only plays a major part in the regulation of blood pressure but also participates in several other physiological functions, including renal development and male reproduction. Here, Bernstein et al. discuss how ACE enhances both innate and adaptive responses by modulating macrophage and neutrophil function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2018 Category: Urology & Nephrology Authors: Kenneth E. Bernstein Zakir Khan Jorge F. Giani Duo-Yao Cao Ellen A. Bernstein Xiao Z. Shen Source Type: research

Autoimmunity: IL-17C promotes immune-mediated glomerular disease
Autoimmunity: IL-17C promotes immune-mediated glomerular disease, Published online: 19 March 2018; doi:10.1038/nrneph.2018.22Autoimmunity: IL-17C promotes immune-mediated glomerular disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 19, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Autoimmunity: Increased PGD2 signalling in lupus pathogenesis
Autoimmunity: Increased PGD2 signalling in lupus pathogenesis, Published online: 12 March 2018; doi:10.1038/nrneph.2018.21Autoimmunity: Increased PGD2 signalling in lupus pathogenesis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 12, 2018 Category: Urology & Nephrology Authors: Jack M. Heintze Source Type: research

Regeneration: Interstitial–epithelial crosstalk
Regeneration: Interstitial–epithelial crosstalkRegeneration: Interstitial–epithelial crosstalk, Published online: 05 March 2018; doi:10.1038/nrneph.2018.20Regeneration: Interstitial–epithelial crosstalk (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Angiomyolipoma: A link between stemness and tumorigenesis in the kidney
Angiomyolipoma: A link between stemness and tumorigenesis in the kidney, Published online: 05 March 2018; doi:10.1038/nrneph.2018.16The cellular origins of angiomyolipoma and other tuberous sclerosis complex-associated neoplasms are unknown. Now, two studies show that these neoplasms derive from cancer stem cells that originate from multipotent renal epithelial cells. The new findings provide a link between stemness and tumorigenesis in the kidney. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2018 Category: Urology & Nephrology Authors: Francesca Becherucci Paola Romagnani Source Type: research

Environmental pollution and kidney diseases
Environmental pollution and kidney diseases, Published online: 26 February 2018; doi:10.1038/nrneph.2018.11Exposure to environmental pollutants is a major cause of kidney injury and disease worldwide and is a particular problem in the developing world. In this Review, the authors discuss the different environmental pollutants that affect the kidney, and our understanding of the pathogenic mechanisms of environmental pollutants in kidney injury and disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2018 Category: Urology & Nephrology Authors: Xin Xu Sheng Nie Hanying Ding Fan Fan Hou Source Type: research

Hypertension: Role of C3aR and C5aR in Treg cells
Hypertension: Role of C3aR and C5aR in Treg cells, Published online: 26 February 2018; doi:10.1038/nrneph.2018.18Hypertension: Role of C3aR and C5aR in Treg cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Hypertension: CLCN2 chloride channel mutations in primary aldosteronism
Hypertension: CLCN2 chloride channel mutations in primary aldosteronism, Published online: 26 February 2018; doi:10.1038/nrneph.2018.17Hypertension: CLCN2 chloride channel mutations in primary aldosteronism (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 26, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Animal models of monoclonal immunoglobulin-related renal diseases
Animal models of monoclonal immunoglobulin-related renal diseases, Published online: 19 February 2018; doi:10.1038/nrneph.2018.8Monoclonal immunoglobulin deposition produces complex diseases with heterogeneous phenotypes, making it difficult to identify the underlying mechanisms of immunoglobulin aggregation and deposition. In this Review, the authors discuss animal models of various human immunoglobulin deposition diseases, and each model's drawbacks and contributions to our understanding of these diseases. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 19, 2018 Category: Urology & Nephrology Authors: Christophe Sirac Guillermo A. Herrera Paul W. Sanders Vecihi Batuman Sebastien Bender Maria V. Ayala Vincent Javaugue Jiamin Teng Elba A. Turbat-Herrera Michel Cogn é Guy Touchard Nelson Leung Frank Bridoux Source Type: research

Mitochondrial dysfunction in diabetic kidney disease
Mitochondrial dysfunction in diabetic kidney disease, Published online: 19 February 2018; doi:10.1038/nrneph.2018.9Dysfunctional mitochondria are postulated to be central to the development and progression of diabetic kidney disease (DKD). Here, the authors review the role of mitochondrial dysfunction in the pathogenesis of DKD and novel therapeutic strategies to target mitochondria and improve kidney function. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 19, 2018 Category: Urology & Nephrology Authors: Josephine M. Forbes David R. Thorburn Source Type: research

Women's health and kidney disease
Women's health and kidney disease, Published online: 15 February 2018; doi:10.1038/nrneph.2018.12Women's health and kidney disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 15, 2018 Category: Urology & Nephrology Source Type: research

Autoimmunity: TLR7 evades silencing in human immune cells
Autoimmunity: TLR7 evades silencing in human immune cells, Published online: 12 February 2018; doi:10.1038/nrneph.2018.13Autoimmunity: TLR7 evades silencing in human immune cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 12, 2018 Category: Urology & Nephrology Authors: Jack M. Heintze Source Type: research

Risk factors: Childhood kidney disease increases the risk of ESRD in adulthood
Risk factors: Childhood kidney disease increases the risk of ESRD in adulthood, Published online: 12 February 2018; doi:10.1038/nrneph.2018.14Risk factors: Childhood kidney disease increases the risk of ESRD in adulthood (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 12, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

The role of nephrologists in the management of small renal masses
The role of nephrologists in the management of small renal masses, Published online: 05 February 2018; doi:10.1038/nrneph.2018.10Renal cell carcinoma (RCC) is the most common malignancy seen in the nephrology clinic, yet most nephrologists have inadequate knowledge of current treatment options. Here we discuss RCC presentation and therapies, including potential renal adverse effects, and highlight the need for involvement of nephrologists in the multidisciplinary management of this disease. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 5, 2018 Category: Urology & Nephrology Authors: Susie L. Hu Robert H. Weiss Source Type: research

Kidneys and women's health: key challenges and considerations
Kidneys and women's health: key challenges and considerations, Published online: 30 January 2018; doi:10.1038/nrneph.2017.188Here, four leading researchers discuss key considerations related to women's kidney health, including specific risk factors, the main challenges and barriers to care and policies and systems that could be implemented to improve the kidney health of women and their offspring. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 30, 2018 Category: Urology & Nephrology Authors: Gloria E. Ashuntantang Vesna D. Garovic Ita P. Heilberg Liz Lightstone Source Type: research

Renin cells in homeostasis, regeneration and immune defence mechanisms
Renin cells in homeostasis, regeneration and immune defence mechanisms, Published online: 30 January 2018; doi:10.1038/nrneph.2017.186Increasing evidence suggests that renin-expressing cells are involved in a range of physiological processes beyond their traditional role in blood pressure regulation. Here, the authors describe the role of these cells in nephrovascular development, regeneration, oxygen sensing, haematopoiesis and immune responses. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 30, 2018 Category: Urology & Nephrology Authors: R. Ariel Gomez Maria Luisa S. Sequeira-Lopez Source Type: research

Sex-specific differences in hypertension and associated cardiovascular disease
Sex-specific differences in hypertension and associated cardiovascular disease, Published online: 30 January 2018; doi:10.1038/nrneph.2017.189The authors present sexual dimorphism at the molecular, cellular and tissue level and suggest that it contributes to differences in disease onset, susceptibility, prevalence and treatment responses in hypertension and cardiovascular disease. Several factors that confer relative cardioprotection in women are discussed, including biological age, sex hormones, sex chromosome complement and lifestyle. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 30, 2018 Category: Urology & Nephrology Authors: Katrina M. Mirabito Colafella Kate M. Denton Source Type: research

Paradigms of acute kidney injury in the intensive care setting
Paradigms of acute kidney injury in the intensive care setting, Published online: 22 January 2018; doi:10.1038/nrneph.2017.184Acute kidney injury is a heterogeneous clinical syndrome with multiple aetiologies, including sepsis, surgery, hypoperfusion and nephrotoxin exposure. Here, Kellum and Prowle discuss the different causes, phenotypes and pathogenic pathways of AKI and describe how consideration of such paradigms could be used to guide treatment. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: John A. Kellum John R. Prowle Source Type: research

Chronic kidney disease: Key role of exosomes in albumin-induced inflammation
Chronic kidney disease: Key role of exosomes in albumin-induced inflammation, Published online: 22 January 2018; doi:10.1038/nrneph.2018.6Chronic kidney disease: Key role of exosomes in albumin-induced inflammation (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Renal physiology: TRPC5 inhibition to treat progressive kidney disease
Renal physiology: TRPC5 inhibition to treat progressive kidney disease, Published online: 22 January 2018; doi:10.1038/nrneph.2018.4Focal segmental glomerulosclerosis (FSGS) is a common and progressive form of kidney injury for which treatment options are limited. New findings from a study in animal models of FSGS suggest that a small molecule inhibitor of the TRPC5 ion channel could provide therapeutic benefit. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Jenny van der Wijst Ren é J. M. Bindels Source Type: research

Reproductive health and pregnancy in women with chronic kidney disease
Reproductive health and pregnancy in women with chronic kidney disease, Published online: 22 January 2018; doi:10.1038/nrneph.2017.187Chronic kidney disease (CKD) is associated with an increased risk of adverse pregnancy outcomes. Here, Wiles et al. discuss fertility issues, contraception, important comorbidities, drugs commonly used in nephrology and the effect of dialysis provision in the context of CKD. Advances in biomarkers for CKD and pre-eclampsia are also presented. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Kate S. Wiles Catherine Nelson-Piercy Kate Bramham Source Type: research

Acute kidney injury: Antioxidants do not PRESERVE kidney function after contrast exposure
Acute kidney injury: Antioxidants do not PRESERVE kidney function after contrast exposure, Published online: 22 January 2018; doi:10.1038/nrneph.2017.185New data from the PRESERVE trial suggest that administration of N-acetylcysteine and/or sodium bicarbonate does not reduce the incidence of acute kidney injury in patients with chronic kidney disease undergoing angiography. Given the limitations of this study, use of these antioxidants should be considered discretionary until further data becomes available. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Richard Solomon Source Type: research

Kidney cancer: PBRM1 loss promotes tumour response to immunotherapy
Kidney cancer: PBRM1 loss promotes tumour response to immunotherapy, Published online: 22 January 2018; doi:10.1038/nrneph.2018.7Kidney cancer: PBRM1 loss promotes tumour response to immunotherapy (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Grant Otto Source Type: research

Acute kidney injury: Macrophage extracellular traps in rhabdomyolysis-induced AKI
Acute kidney injury: Macrophage extracellular traps in rhabdomyolysis-induced AKI, Published online: 22 January 2018; doi:10.1038/nrneph.2018.5Acute kidney injury: Macrophage extracellular traps in rhabdomyolysis-induced AKI (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease
Sex and gender disparities in the epidemiology and outcomes of chronic kidney diseaseSex and gender disparities in the epidemiology and outcomes of chronic kidney disease, Published online: 22 January 2018; doi:10.1038/nrneph.2017.181A growing body of research indicates that sex and gender-specific differences exist in the mechanisms and epidemiology of chronic kidney disease (CKD). Here, the authors describe current understanding of gender and sex differences in the epidemiology, treatment and outcomes of CKD, as well as the possible underlying causes. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 22, 2018 Category: Urology & Nephrology Authors: Juan Jesus Carrero Manfred Hecking Nicholas C. Chesnaye Kitty J. Jager Source Type: research

Epigenetics: H3K27me3 in glomerular disease
Epigenetics: H3K27me3 in glomerular disease, Published online: 15 January 2018; doi:10.1038/nrneph.2018.1Epigenetics: H3K27me3 in glomerular disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 15, 2018 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom, Published online: 15 January 2018; doi:10.1038/nrneph.2017.169Some animals have developed mechanisms to protect them from environmental stresses, whereas others remain susceptible. Here, Stenvinkel et al. discuss how a better understanding of susceptibility and protective mechanisms could provide insights to novel strategies for the prevention and treatment of several human diseases, such as chronic kidney disease and ageing-associated complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 15, 2018 Category: Urology & Nephrology Authors: Peter Stenvinkel Johanna Painer Makoto Kuro-o Miguel Lanaspa Walter Arnold Thomas Ruf Paul G. Shiels Richard J. Johnson Source Type: research

Sepsis: The podoplanin–CLEC2 axis in sepsis
Sepsis: The podoplanin–CLEC2 axis in sepsisSepsis: The podoplanin–CLEC2 axis in sepsis, Published online: 15 January 2018; doi:10.1038/nrneph.2018.2Sepsis: The podoplanin–CLEC2 axis in sepsis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 15, 2018 Category: Urology & Nephrology Authors: Grant Otto Source Type: research

Thrombotic microangiopathy: Pregnancy outcomes in aHUS
Thrombotic microangiopathy: Pregnancy outcomes in aHUS, Published online: 15 January 2018; doi:10.1038/nrneph.2018.3Thrombotic microangiopathy: Pregnancy outcomes in aHUS (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 15, 2018 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Genomic medicine for kidney disease
Genomic medicine for kidney disease, Published online: 08 January 2018; doi:10.1038/nrneph.2017.167Genomic medicine approaches are increasingly used for diagnosis of kidney disease. Here, the authors discuss sequencing modalities, the interpretation and clinical application of genetic data, and the challenges that must be overcome to realize the potential of genomic medicine in nephrology. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 8, 2018 Category: Urology & Nephrology Authors: Emily E. Groopman Hila Milo Rasouly Ali G. Gharavi Source Type: research

Diabetic kidney disease in 2017: A new era in therapeutics for diabetic kidney disease
Diabetic kidney disease in 2017: A new era in therapeutics for diabetic kidney disease, Published online: 08 January 2018; doi:10.1038/nrneph.2017.1822017 saw the emergence of a new era in renoprotective medicine for diabetic kidney disease with reports of promising renal outcomes with the sodium–glucose cotransporter 2 (SGLT2) inhibitors empagliflozin and canagliflozin from follow-up analyses of the EMPA-REG OUTCOME trial and the CANVAS Program, respectively, and with use of the glucagon-like peptide 1 (GLP1) agonist liraglutide in the LEADER trial. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 8, 2018 Category: Urology & Nephrology Authors: Christoph Wanner Source Type: research

Genetics of kidney diseases in 2017: Unveiling the genetic architecture of kidney disease
Genetics of kidney diseases in 2017: Unveiling the genetic architecture of kidney disease, Published online: 08 January 2018; doi:10.1038/nrneph.2017.177Technical advances in genome sequencing and association studies have yielded critical insights into the genetic architecture of kidney diseases. Here, I summarize four key studies from 2017 that deciphered the genetic basis of known and novel diseases and provided insights into the mechanisms of glomerular, developmental defects and manifestations of kidney disorders. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 8, 2018 Category: Urology & Nephrology Authors: Olivier Devuyst Source Type: research

Hypertension in 2017: Novel mechanisms of hypertension and vascular dysfunction
Hypertension in 2017: Novel mechanisms of hypertension and vascular dysfunction, Published online: 02 January 2018; doi:10.1038/nrneph.2017.178New findings in 2017 enhanced our understanding of the mechanisms that regulate blood pressure. Key studies provided insights into immune mechanisms, the role of the gut microbiota, the adverse effects of perivascular fat and inflammation on the vasculature, and the contribution of rare variants in renin–angiotensin–aldosterone system genes to salt sensitivity. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 2, 2018 Category: Urology & Nephrology Authors: Ernesto L. Schiffrin Source Type: research

Polycystic kidney disease: Tolvaptan slows disease progression in late-stage ADPKD
Polycystic kidney disease: Tolvaptan slows disease progression in late-stage ADPKD, Published online: 02 January 2018; doi:10.1038/nrneph.2017.180New data from the REPRISE trial confirms that tolvaptan slows the progression of autosomal dominant polycystic disease (ADPKD). Although not yet approved by the United States Food and Drug administration, tolvaptan is now likely to become standard care for early and later stages of ADPKD in Europe and in various countries worldwide. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 2, 2018 Category: Urology & Nephrology Authors: Albert C. M. Ong Source Type: research

Scleroderma renal crisis and renal involvement in systemic sclerosis
Scleroderma renal crisis and renal involvement in systemic sclerosis, Published online: 02 January 2018; doi:10.1038/nrneph.2017.183Scleroderma renal crisis and renal involvement in systemic sclerosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - January 2, 2018 Category: Urology & Nephrology Authors: Thasia G. Woodworth Yossra A. Suliman Wendi Li Daniel E. Furst Philip Clements Source Type: research

Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease
Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease, Published online: 18 December 2017; doi:10.1038/nrneph.2017.173Studies of cellular energetics have revealed important roles of metabolic pathways in determining cell fate and response to injury. Insights from 2017 into the mechanisms underlying these pathways might identify therapeutic targets to minimize injury and promote repair. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Ton J. Rabelink Peter Carmeliet Source Type: research

Immune-mediated kidney disease in 2017: Progress in mechanisms and therapy for immunological kidney disease
Immune-mediated kidney disease in 2017: Progress in mechanisms and therapy for immunological kidney disease, Published online: 18 December 2017; doi:10.1038/nrneph.2017.171In 2017, progress was made in several aspects of immune-mediated kidney disease. Mechanistic studies provided new insights into the underlying signals that confer risk to, or protection from, immune pathways, whereas new approaches to the treatment of immunological kidney disease will hopefully translate into a move away from the use of toxic corticosteroids. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Stephen R. Holdsworth A. Richard Kitching Source Type: research

Genetic engineering: Trans-epigenetic modulation of target genes in acute kidney injury
Genetic engineering: Trans-epigenetic modulation of target genes in acute kidney injury, Published online: 18 December 2017; doi:10.1038/nrneph.2017.179Genetic engineering: Trans-epigenetic modulation of target genes in acute kidney injury (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 18, 2017 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis
Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis, Published online: 13 December 2017; doi:10.1038/nrneph.2017.174Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - December 13, 2017 Category: Urology & Nephrology Authors: Connie M. Rhee Kamyar Kalantar-Zadeh Source Type: research