The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD
Nature Reviews Nephrology, Published online: 11 July 2019; doi:10.1038/s41581-019-0174-zThis Perspectives article considers why clinical trials of urate-lowering therapy (ULT) have shown inconsistent renoprotective effects in patients with chronic kidney disease, and suggests that sufficient evidence exists to support the use of routine screening for hyperuricaemia and initiation of ULT in selected patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 11, 2019 Category: Urology & Nephrology Authors: Yuka Sato Daniel I. Feig Austin G. Stack Duk-Hee Kang Miguel A. Lanaspa A. Ahsan Ejaz L. Gabriela S ánchez-Lozada Masanari Kuwabara Claudio Borghi Richard J. Johnson Source Type: research

ER calcium stabilizers in NS
Nature Reviews Nephrology, Published online: 10 July 2019; doi:10.1038/s41581-019-0180-1ER calcium stabilizers in NS (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 10, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Gene signatures reveal kidney immune cells
Nature Reviews Nephrology, Published online: 08 July 2019; doi:10.1038/s41581-019-0179-7Gene signatures reveal kidney immune cells (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 8, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

A single-cell, 2D atlas of the normal human kidney using imaging mass cytometry
Nature Reviews Nephrology, Published online: 02 July 2019; doi:10.1038/s41581-019-0177-9A single-cell, 2D atlas of the normal human kidney using imaging mass cytometry (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - July 2, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Histocompatibility: minor differences have a major impact
Nature Reviews Nephrology, Published online: 28 June 2019; doi:10.1038/s41581-019-0175-yThe clinical relevance of minor histocompatibility antigens in transplantation is disputed. High-throughput approaches are now being used to investigate the role of genome-wide genetic incompatibility in transplant outcomes. A recent study reports that donor and recipient mismatch at the LIMS1 locus is associated with an increased risk of acute rejection. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 28, 2019 Category: Urology & Nephrology Authors: Roman Reindl-Schwaighofer Rainer Oberbauer Source Type: research

Intestinal microbiome and fitness in kidney disease
Nature Reviews Nephrology, Published online: 26 June 2019; doi:10.1038/s41581-019-0172-1The microbiome is increasingly recognized as an element that contributes to health and disease. Here, the authors take an ecological approach to describe the impact of factors related to chronic kidney disease on the fitness of different physiological systems and the effects of these changes on microbiota composition. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 26, 2019 Category: Urology & Nephrology Authors: Bj örn Meijers Pieter Evenepoel Hans-Joachim Anders Source Type: research

The role of sodium in modulating immune cell function
Nature Reviews Nephrology, Published online: 25 June 2019; doi:10.1038/s41581-019-0167-ySodium has a crucial role in osmoregulation and fluid balance. In this Review, the authors discuss how sodium is also an important functional modulator of innate and adaptive immune cells and how it might be linked to chronic inflammatory conditions. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 25, 2019 Category: Urology & Nephrology Authors: Nicola Wilck Andr ás Balogh Lajos Mark ó Hendrik Bartolomaeus Dominik N. M üller Source Type: research

CREDENCE and DELIGHT deliver on renal benefits
Nature Reviews Nephrology, Published online: 25 June 2019; doi:10.1038/s41581-019-0171-2Inhibitors of sodium–glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase 4 (DPP4) are widely used in patients with type 2 diabetes to improve glycaemic control and reduce cardiovascular risks. Two recent clinical trials, CREDENCE and DELIGHT, demonstrate that these drugs can also slow down the progression of kidney disease in these patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 25, 2019 Category: Urology & Nephrology Authors: Christoph Wanner Susanne Brenner Source Type: research

Considerations for SGLT2 inhibitor use in post-transplantation diabetes
Nature Reviews Nephrology, Published online: 24 June 2019; doi:10.1038/s41581-019-0173-0Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been recommended for the treatment of patients with type 2 diabetes mellitus and cardiovascular disease, heart failure or chronic kidney disease. Findings from recent efficacy and safety trials of empagliflozin in kidney transplant recipients with post-transplantation diabetes are timely, given the elevated cardiovascular risk associated with solid organ transplantation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 24, 2019 Category: Urology & Nephrology Authors: Manfred Hecking Trond Jenssen Source Type: research

SONAR propels endothelin A receptor antagonists to success
This study was designed to select patients who were likely to benefit from the therapy and minimize the risk of adverse effects. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 19, 2019 Category: Urology & Nephrology Authors: Jennifer S. Pollock David M. Pollock Source Type: research

Extracellular DNA traps in inflammation, injury and healing
Nature Reviews Nephrology, Published online: 18 June 2019; doi:10.1038/s41581-019-0163-2Various cell types release extracellular DNA traps that protect the host against microbial infections. In this Review, the authors discuss how DNA traps not only participate in pathogen clearance but can also promote vascular disease and autoimmunity. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 18, 2019 Category: Urology & Nephrology Authors: Christoph Daniel Moritz Leppkes Luis E. Mu ñoz Gunnar Schley Georg Schett Martin Herrmann Source Type: research

A million genotypes to find CKD-linked loci
Nature Reviews Nephrology, Published online: 14 June 2019; doi:10.1038/s41581-019-0170-3A million genotypes to find CKD-linked loci (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 14, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease
Nature Reviews Nephrology, Published online: 13 June 2019; doi:10.1038/s41581-019-0161-4This Evidence-Based Guideline developed by members of the European Society for Paediatric Nephrology CKD-MBD, Dialysis and Transplantation working groups presents clinical practice recommendations for the use of growth hormone in children with chronic kidney disease on dialysis and after renal transplantation. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 13, 2019 Category: Urology & Nephrology Authors: Jens Drube Mandy Wan Marjolein Bonthuis Elke W ühl Justine Bacchetta Fernando Santos Ryszard Grenda Alberto Edefonti Jerome Harambat Rukshana Shroff Burkhard T önshoff Dieter Haffner Source Type: research

Nephropathic autoantigens in the spectrum of lupus nephritis
Nature Reviews Nephrology, Published online: 13 June 2019; doi:10.1038/s41581-019-0168-xIn a collaborative effort, researchers have identified unusual protein deposits of exostosin 1 and exostosin 2 in patients with PLA2R and THSD7A-negative membranous nephropathy, many of whom had systemic lupus erythematosus, lupus nephritis or other forms of autoimmunity. Although serum exostosin antibodies were not detected, the findings suggest that these proteins could define a distinct subtype of membranous nephropathy. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 13, 2019 Category: Urology & Nephrology Authors: Hans-Joachim Anders Source Type: research

Using and producing publicly available genomic data to accelerate discovery in nephrology
Nature Reviews Nephrology, Published online: 10 June 2019; doi:10.1038/s41581-019-0166-zTo advance kidney discovery, our community is driven to maximize the utility of genomic data that we all generate. We can best accomplish this through excellence in appropriately incorporating publicly available genomic data into our research efforts and by enthusiastically embracing widespread data sharing in a manner that facilitates its broad use. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 10, 2019 Category: Urology & Nephrology Authors: Matthew G. Sampson Hyun Min Kang Source Type: research

Mechanisms of phosphate transport
Nature Reviews Nephrology, Published online: 05 June 2019; doi:10.1038/s41581-019-0159-yThis Review describes the mechanisms by which dietary, hormonal and metabolic factors regulate the expression and function of sodium-dependent phosphate cotransporters. The authors discuss the consequences of dysregulated phosphate transport and how understanding of the structure–function relationships of the transporters provides insights into their transport mechanisms. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 5, 2019 Category: Urology & Nephrology Authors: Moshe Levi Enrico Gratton Ian C. Forster Nati Hernando Carsten A. Wagner Juerg Biber Victor Sorribas Heini Murer Source Type: research

A molecular imaging approach for the early, real-time diagnosis of acute kidney injury
Nature Reviews Nephrology, Published online: 05 June 2019; doi:10.1038/s41581-019-0165-0A molecular imaging approach for the early, real-time diagnosis of acute kidney injury (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis
Nature Reviews Nephrology, Published online: 04 June 2019; doi:10.1038/s41581-019-0164-1Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

The (pro)renin receptor in health and disease
Nature Reviews Nephrology, Published online: 04 June 2019; doi:10.1038/s41581-019-0160-5Here, the authors discuss the multiple functions of the (pro)renin receptor in physiological processes, including blood pressure regulation, energy metabolism and autophagy, as well as its roles in the pathogenesis of diseases including fibrosis, chronic kidney disease, pre-eclampsia and cancer. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Atsuhiro Ichihara Midori Sasaki Yatabe Source Type: research

The role of inflammasomes in kidney disease
Nature Reviews Nephrology, Published online: 04 June 2019; doi:10.1038/s41581-019-0158-zIn this Review, the authors discuss the biology of canonical and non-canonical inflammasomes and inflammasome-forming genes in the kidney, including their different functions in the various kidney compartments and their potential as therapeutic targets. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - June 4, 2019 Category: Urology & Nephrology Authors: Takanori Komada Daniel A. Muruve Source Type: research

International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people
Nature Reviews Nephrology, Published online: 22 May 2019; doi:10.1038/s41581-019-0155-2This Consensus Statement developed on behalf of the Network for Early Onset Cystic Kidney Disease provides guidance on counselling, diagnosing and monitoring children with autosomal dominant polycystic kidney disease based on current evidence and a multi-stakeholder discussion of ethical issues. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 22, 2019 Category: Urology & Nephrology Authors: Charlotte Gimpel Carsten Bergmann Detlef Bockenhauer Luc Breysem Melissa A. Cadnapaphornchai Metin Cetiner Jan Dudley Francesco Emma Martin Konrad Tess Harris Peter C. Harris Jens K önig Max C. Liebau Matko Marlais Djalila Mekahli Alison M. Metcalfe Jun Source Type: research

PC2–mitochondria interactions in PKD
Nature Reviews Nephrology, Published online: 22 May 2019; doi:10.1038/s41581-019-0162-3PC2–mitochondria interactions in PKD (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 22, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Antimicrobial resistance in nephrology
Antimicrobial resistance in nephrology, Published online: 13 May 2019; doi:10.1038/s41581-019-0150-7Antimicrobial resistance is an emergent global problem and patients with chronic kidney disease have some of the highest rates of colonization and infection with antibiotic-resistant bacteria (ARB). This Review focuses on the epidemiology, prevention and treatment of infections with ARB. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 13, 2019 Category: Urology & Nephrology Authors: Tina Z. Wang Rosy Priya L. Kodiyanplakkal David P. Calfee Source Type: research

Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia, Published online: 08 May 2019; doi:10.1038/s41581-019-0152-5In this Evidence-Based Guideline on X-linked hypophosphataemia, the authors identify the criteria for diagnosis of this disease, provide guidance for medical and surgical treatment and explain the challenges of follow-up. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 8, 2019 Category: Urology & Nephrology Authors: Dieter Haffner Francesco Emma Deborah M. Eastwood Martin Biosse Duplan Justine Bacchetta Dirk Schnabel Philippe Wicart Detlef Bockenhauer Fernando Santos Elena Levtchenko Pol Harvengt Martha Kirchhoff Federico Di Rocco Catherine Chaussain Maria Louisa Bra Source Type: research

Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies
Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies, Published online: 08 May 2019; doi:10.1038/s41581-019-0156-1Author Correction: Pre-eclampsia: pathogenesis, novel diagnostics and therapies (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 8, 2019 Category: Urology & Nephrology Authors: Elizabeth A. Phipps Ravi Thadhani Thomas Benzing S. Ananth Karumanchi Source Type: research

A signature of inflammatory proteins associated with ESRD in diabetes
A signature of inflammatory proteins associated with ESRD in diabetes, Published online: 03 May 2019; doi:10.1038/s41581-019-0157-0A signature of inflammatory proteins associated with ESRD in diabetes (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 3, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Cardiovascular disease in young adults with incident ESRD
Cardiovascular disease in young adults with incident ESRD, Published online: 01 May 2019; doi:10.1038/s41581-019-0154-3Cardiovascular disease (CVD) is a leading cause of death in young adults with incident end-stage renal disease (ESRD). Unlike children with ESRD, young adults with incident ESRD have high prevalence of diabetes, coronary artery disease and heart failure. These cardiovascular risk factors are associated with increased CVD-related hospitalizations and mortality in young adults. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - May 1, 2019 Category: Urology & Nephrology Authors: Elaine Ku Mark M. Mitsnefes Source Type: research

The ubiquitin–proteasome system in kidney physiology and disease
The ubiquitin–proteasome system in kidney physiology and diseaseThe ubiquitin–proteasome system in kidney physiology and disease, Published online: 29 April 2019; doi:10.1038/s41581-019-0148-1The ubiquitin–proteasome system (UPS) maintains protein homeostasis through the selective degradation of proteins. In addition to degrading short-lived and misfolded proteins, the UPS regulates a multitude of cellular processes, including gene transcription and translation, cell survival and metabolism, and inflammation. This Review provides an overview of UPS-mediated proteostasis, focusing on the involvem...
Source: Nature Reviews Nephrology - April 29, 2019 Category: Urology & Nephrology Authors: Catherine Meyer-Schwesinger Source Type: research

Obesity, kidney dysfunction and hypertension: mechanistic links
Obesity, kidney dysfunction and hypertension: mechanistic links, Published online: 23 April 2019; doi:10.1038/s41581-019-0145-4Hypertension is one of the most common comorbid conditions that is associated with obesity. Here, the authors discuss the complex interactions between renal, hormonal and nervous system factors that link excess adiposity with elevated blood pressure. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 23, 2019 Category: Urology & Nephrology Authors: John E. Hall Jussara M. do Carmo Alexandre A. da Silva Zhen Wang Michael E. Hall Source Type: research

Measuring fibrosis without biopsies
Measuring fibrosis without biopsies, Published online: 18 April 2019; doi:10.1038/s41581-019-0153-4Measuring fibrosis without biopsies (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 18, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Immune-based combination therapy for metastatic kidney cancer
Immune-based combination therapy for metastatic kidney cancer, Published online: 16 April 2019; doi:10.1038/s41581-019-0149-0New data from the JAVELIN Renal 101 and KEYNOTE-426 trials provide evidence that immune-based combination therapy has superior efficacy to sunitinib monotherapy in patients with advanced renal cell carcinoma. The new findings raise important questions regarding the optimum choice of combination therapy for these patients. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 16, 2019 Category: Urology & Nephrology Authors: Camillo Porta Mimma Rizzo Source Type: research

Unique metabolic traits identify CCPAP
Unique metabolic traits identify CCPAP, Published online: 15 April 2019; doi:10.1038/s41581-019-0151-6Unique metabolic traits identify CCPAP (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 15, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Structure and function of polycystins: insights into polycystic kidney disease
Structure and function of polycystins: insights into polycystic kidney disease, Published online: 04 April 2019; doi:10.1038/s41581-019-0143-6Autosomal dominant polycystic kidney disease (ADPKD) is caused by pathogenic mutations in the genes that encode polycystin 1 (PC1) and PC2. In this article, the authors discuss findings from structural and electrophysiological studies that give us insight into the function of polycystins and ADPKD pathogenesis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 4, 2019 Category: Urology & Nephrology Authors: Dominique Douguet Amanda Patel Eric Honor é Source Type: research

VE-PTP phosphatase: a new target for diabetic kidney disease
VE-PTP phosphatase: a new target for diabetic kidney disease, Published online: 01 April 2019; doi:10.1038/s41581-019-0147-2VE-PTP phosphatase: a new target for diabetic kidney disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 1, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

A novel SGLT1-mediated mechanism of hyperglycaemia-induced hyperfiltration
A novel SGLT1-mediated mechanism of hyperglycaemia-induced hyperfiltration, Published online: 01 April 2019; doi:10.1038/s41581-019-0146-3A novel SGLT1-mediated mechanism of hyperglycaemia-induced hyperfiltration (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 1, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Gut microbial short-chain fatty acids and the risk of diabetes
Gut microbial short-chain fatty acids and the risk of diabetes, Published online: 27 March 2019; doi:10.1038/s41581-019-0142-7A new study used genome-wide association data and Mendelian randomization to investigate associations between the gut microbiome and metabolic traits. The researchers demonstrate that host genetic variants influence levels of the short-chain fatty acids butyrate and propionate in the gut, which in turn modulate host glycaemic metabolism. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 27, 2019 Category: Urology & Nephrology Authors: Wei Ling Lau Nosratola D. Vaziri Source Type: research

The adjuvant treatment of kidney cancer: a multidisciplinary outlook
The adjuvant treatment of kidney cancer: a multidisciplinary outlook, Published online: 26 March 2019; doi:10.1038/s41581-019-0131-xEffective adjuvant therapies are needed to reduce the risk of recurrence of kidney cancer. Here, the authors discuss the results of adjuvant therapy trials, the potential of immune checkpoint inhibitors as adjuvant therapies and the need for multidisciplinary management of patients with resected kidney cancer. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 26, 2019 Category: Urology & Nephrology Authors: Camillo Porta Laura Cosmai Bradley C. Leibovich Thomas Powles Maurizio Gallieni Axel Bex Source Type: research

Repurposing CAR T cells to treat SLE
Repurposing CAR T cells to treat SLE, Published online: 25 March 2019; doi:10.1038/s41581-019-0144-5Repurposing CAR T cells to treat SLE (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 25, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Introducing routine genetic testing for patients with CKD
Introducing routine genetic testing for patients with CKD, Published online: 22 March 2019; doi:10.1038/s41581-019-0140-9Chronic kidney disease (CKD) is often clinically silent and traditional clinical data alone cannot differentiate disease subtypes. A recent study of the genetic basis of CKD in adults that examined the prevalence of monogenic kidney disease aetiologies supports the use of genetic analysis to improve diagnostics and treatment in CKD. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 22, 2019 Category: Urology & Nephrology Authors: Asaf Vivante Karl Skorecki Source Type: research

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
Epigenetics and epigenomics in diabetic kidney disease and metabolic memory, Published online: 20 March 2019; doi:10.1038/s41581-019-0135-6This Review describes the current understanding of the role of epigenetics and epigenomics in diabetic kidney disease (DKD) and how epigenetic mechanisms might contribute to metabolic memory. The authors also discuss how epigenetic factors and non-coding RNAs could be used as biomarkers and drug targets for DKD diagnosis, prognosis and treatment. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 20, 2019 Category: Urology & Nephrology Authors: Mitsuo Kato Rama Natarajan Source Type: research

Not your usual parietal cell
Not your usual parietal cell, Published online: 18 March 2019; doi:10.1038/s41581-019-0141-8Not your usual parietal cell (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 18, 2019 Category: Urology & Nephrology Authors: Monica Wang Source Type: research

Glycosylation in health and disease
Glycosylation in health and disease, Published online: 11 March 2019; doi:10.1038/s41581-019-0129-4Glycosylation refers to the addition of carbohydrate chains to proteins and lipids. In this Review, the authors discuss the broad role of glycans in immunity, cancer, xenotransplantation and glomerular filtration and the potential of ‘glycomedicine’. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 11, 2019 Category: Urology & Nephrology Authors: Colin Reily Tyler J. Stewart Matthew B. Renfrow Jan Novak Source Type: research

Evidence-based therapy for undocumented immigrants with ESRD
Evidence-based therapy for undocumented immigrants with ESRD, Published online: 08 March 2019; doi:10.1038/s41581-019-0137-4Haemodialysis options for undocumented immigrants with end-stage renal disease range from standard of care thrice-weekly treatments to emergency-only haemodialysis. This latter approach is associated with poor patient outcomes and high costs. The time has come for the nephrology community to demand an end to the practice of emergency-only haemodialysis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 8, 2019 Category: Urology & Nephrology Authors: Rudolph A. Rodriguez Source Type: research

Tubuloids for modelling kidney disease
Tubuloids for modelling kidney disease, Published online: 05 March 2019; doi:10.1038/s41581-019-0138-3Tubuloids for modelling kidney disease (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Nanosensors enable early detection of acute T cell-mediated rejection of transplants
Nanosensors enable early detection of acute T cell-mediated rejection of transplants, Published online: 05 March 2019; doi:10.1038/s41581-019-0134-7Nanosensors enable early detection of acute T cell-mediated rejection of transplants (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

A materials approach for kidney organoids
A materials approach for kidney organoids, Published online: 05 March 2019; doi:10.1038/s41581-019-0139-2A materials approach for kidney organoids (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 5, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

ABCF1 switches off inflammation in sepsis
ABCF1 switches off inflammation in sepsis, Published online: 01 March 2019; doi:10.1038/s41581-019-0136-5ABCF1 switches off inflammation in sepsis (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 1, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Macrophages support kidney and vasculature assembly in development
Macrophages support kidney and vasculature assembly in development, Published online: 27 February 2019; doi:10.1038/s41581-019-0133-8Macrophages support kidney and vasculature assembly in development (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 27, 2019 Category: Urology & Nephrology Authors: Susan J. Allison Source Type: research

Succinate homeostasis protects against lithogenesis and hypertension
Succinate homeostasis protects against lithogenesis and hypertension, Published online: 25 February 2019; doi:10.1038/s41581-019-0132-9Succinate homeostasis protects against lithogenesis and hypertension (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: Ellen F. Carney Source Type: research

Immune mechanisms of salt-sensitive hypertension and renal end-organ damage
Immune mechanisms of salt-sensitive hypertension and renal end-organ damage, Published online: 25 February 2019; doi:10.1038/s41581-019-0121-zImmune mechanisms have important roles in the development of hypertension and end-organ damage. In this Review, David Mattson discusses these mechanisms with a focus on salt-sensitive hypertension and adaptive immunity. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - February 25, 2019 Category: Urology & Nephrology Authors: David L. Mattson Source Type: research