Excessive daytime sleepiness in general hospital nurses: prevalence, correlates, and its association with adverse events
ConclusionsEDS was common among this relatively young and healthy nurse population in south China. There were clear associations between EDS and depression, anxiety, insomnia, rotating shift work, and low work-related interest. Furthermore, EDS was an independent risk factor in the occurrence of adverse events (AEs) in our subjects. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 16, 2018 Category: Respiratory Medicine Source Type: research

Accuracy of portable devices in sleep apnea using oximetry-derived heart rate increases as a surrogate arousal marker
ConclusionsIn this retrospective analysis, the diagnostic accuracy of type 3 HS was improved by the inclusion of hypopnea-associated heart rate increases as a surrogate marker of arousal. Prospective studies are warranted to evaluate the impact of AnH scoring on clinical decision-making and patient outcomes. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 15, 2018 Category: Respiratory Medicine Source Type: research

Response to a letter to the editor by Mohammad Rasoul Ghadami et al.: "Obstructive sleep apnea in veterans with post-traumatic stress disorder: looking beyond their complaint".
Response to a letter to the editor by Mohammad Rasoul Ghadami et al.: "Obstructive sleep apnea in veterans with post-traumatic stress disorder: looking beyond their complaint". Sleep Breath. 2018 Aug 13;: Authors: Rezaeitalab F, Mokhber N, Ravanshad Y, Saberi S, Rezaeetalab F PMID: 30105584 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 13, 2018 Category: Sleep Medicine Authors: Rezaeitalab F, Mokhber N, Ravanshad Y, Saberi S, Rezaeetalab F Tags: Sleep Breath Source Type: research

Response to a letter to the editor by Mohammad Rasoul Ghadami et al.: “Obstructive sleep apnea in veterans with post-traumatic stress disorder: looking beyond their complaint”
(Source: Sleep and Breathing)
Source: Sleep and Breathing - August 13, 2018 Category: Respiratory Medicine Source Type: research

Toll-like receptor-4 deficiency alleviates chronic intermittent hypoxia-induced renal injury, inflammation, and fibrosis.
CONCLUSIONS: Our data suggest that TLR4 plays a vital role in CIH-induced renal injury, inflammation and fibrosis, and inhibition of TLR4 probably provides a therapeutic potential for CIH-induced kidney damage. PMID: 30099700 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 11, 2018 Category: Sleep Medicine Authors: Zhang Y, Su X, Zou F, Xu T, Pan P, Hu C Tags: Sleep Breath Source Type: research

Toll-like receptor-4 deficiency alleviates chronic intermittent hypoxia-induced renal injury, inflammation, and fibrosis
ConclusionsOur data suggest that TLR4 plays a vital role in CIH-induced renal injury, inflammation and fibrosis, and inhibition of TLR4 probably provides a therapeutic potential for CIH-induced kidney damage. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 11, 2018 Category: Respiratory Medicine Source Type: research

Catestatin serum levels are increased in male patients with obstructive sleep apnea.
Abstract PURPOSE: Obstructive sleep apnea (OSA) is a complex sleep disorder associated with autonomic and sympathetic dysregulation. To the contrary, catestatin, an endogenous pleiotropic peptide cleaved from chromogranin A, is known for its inhibitory effects on catecholamine release and sympathetic activity. The aims of the study were to determine catestatin serum levels among male OSA patients compared to healthy control subjects and to explore associations of catestatin with anthropometric, polysomnographic, and lipid profile parameters. METHODS: Seventy-eight male OSA patients aged 50.3 ±&t...
Source: Sleep and Breathing - August 7, 2018 Category: Sleep Medicine Authors: Borovac JA, Dogas Z, Supe-Domic D, Galic T, Bozic J Tags: Sleep Breath Source Type: research

Lack of correlation between CSF glutamate levels and PSQI scores in heavy smokers.
Abstract OBJECTIVE: Glutamate is an excitatory neurotransmitter in the central nervous system that participates in initiation and maintenance of sleep and wakefulness. The mechanisms involved occur in the brainstem, lateral hypothalamus, and basal forebrain. Our previous study suggested that higher levels of glutamate in cerebrospinal fluid (CSF) contributed to poorer sleep quality. Smoking has been shown to be harmful to sleep quality. In the present study, we recruited non-smokers and heavy smokers and measured the concentration of CSF glutamate in order to investigate the associations among smoking status, slee...
Source: Sleep and Breathing - August 7, 2018 Category: Sleep Medicine Authors: Xu J, Li H, Wang F, Xu Z, Li G, Ding C, Wu J, Kang Y, Li H, Xu H, Liu Y Tags: Sleep Breath Source Type: research

Lack of correlation between CSF glutamate levels and PSQI scores in heavy smokers
AbstractObjectiveGlutamate is an excitatory neurotransmitter in the central nervous system that participates in initiation and maintenance of sleep and wakefulness. The mechanisms involved occur in the brainstem, lateral hypothalamus, and basal forebrain. Our previous study suggested that higher levels of glutamate in cerebrospinal fluid (CSF) contributed to poorer sleep quality. Smoking has been shown to be harmful to sleep quality. In the present study, we recruited non-smokers and heavy smokers and measured the concentration of CSF glutamate in order to investigate the associations among smoking status, sleep quality, a...
Source: Sleep and Breathing - August 7, 2018 Category: Respiratory Medicine Source Type: research

Catestatin serum levels are increased in male patients with obstructive sleep apnea
AbstractPurposeObstructive sleep apnea (OSA) is a complex sleep disorder associated with autonomic and sympathetic dysregulation. To the contrary, catestatin, an endogenous pleiotropic peptide cleaved from chromogranin A, is known for its inhibitory effects on catecholamine release and sympathetic activity. The aims of the study were to determine catestatin serum levels among male OSA patients compared to healthy control subjects and to explore associations of catestatin with anthropometric, polysomnographic, and lipid profile parameters.MethodsSeventy-eight male OSA patients aged 50.3  ± 8.8 year...
Source: Sleep and Breathing - August 7, 2018 Category: Respiratory Medicine Source Type: research

Comparison of upper airway collapse patterns and its clinical significance: drug-induced sleep endoscopy in patients without obstructive sleep apnea, positional and non-positional obstructive sleep apnea.
Abstract PURPOSE: To compare patient characteristics, upper airway (UA) collapse patterns and treatment outcome in obstructive sleep apnea (OSA) patients, including non-positional OSA patients (NPP) and positional OSA patients (PP), and non-OSA. METHODS: Cohort study of patients screened for OSA in 2012. Polysomnography was performed and UA was evaluated using the VOTE classification during drug-induced sleep endoscopy (DISE). Treatment outcome of MAD and UA surgery was evaluated. RESULTS: Eight hundred sixty patients were included. Higher BMI, larger neck circumference, and greater age were independent ...
Source: Sleep and Breathing - August 1, 2018 Category: Sleep Medicine Authors: Kastoer C, Benoist LBL, Dieltjens M, Torensma B, de Vries LH, Vonk PE, Ravesloot MJL, de Vries N Tags: Sleep Breath Source Type: research

Comparison of upper airway collapse patterns and its clinical significance: drug-induced sleep endoscopy in patients without obstructive sleep apnea, positional and non-positional obstructive sleep apnea
AbstractPurposeTo compare patient characteristics, upper airway (UA) collapse patterns and treatment outcome in obstructive sleep apnea (OSA) patients, including non-positional OSA patients (NPP) and positional OSA patients (PP), and non-OSA.MethodsCohort study of patients screened for OSA in 2012. Polysomnography was performed and UA was evaluated using the VOTE classification during drug-induced sleep endoscopy (DISE). Treatment outcome of MAD and UA surgery was evaluated.ResultsEight hundred sixty patients were included. Higher BMI, larger neck circumference, and greater age were independent significant predictors for O...
Source: Sleep and Breathing - August 1, 2018 Category: Respiratory Medicine Source Type: research

Aortic root size is associated with nocturnal blood pressure in a population of hypertensive patients under treatment for obstructive sleep apnea.
Abstract BACKGROUND: Obstructive sleep apnea (OSA) is associated with an increased aortic root size. This association has never been studied in patients with hypertension undergoing continuous positive airway pressure (CPAP) treatment for OSA. METHODS: The 24-h blood pressure (BP) monitoring of 142 hypertensive patients undergoing CPAP treatment for OSA was prospectively documented. Aortic root diameter was assessed by echocardiography. RESULTS: The population included 33.8% women, with an overall mean age of 60.7 ± 10.5 years. The median body mass index was 32.7 [29. 5-36.3]&nb...
Source: Sleep and Breathing - July 24, 2018 Category: Sleep Medicine Authors: Delsart P, Soquet J, Drumez E, Juthier F, Kutoati S, Koutouzi TN, Fry S, Mallart A, Montaigne D, Mounier-Vehier C Tags: Sleep Breath Source Type: research

Reliability of autonomic activations as surrogates of cortical arousals in ventilated patients affected by amyotrophic lateral sclerosis.
CONCLUSIONS: In ventilated ALS patients, autonomic activations may hardly have a role as surrogates of cortical arousals for assessment of sleep fragmentation and for respiratory scoring. Depression of ANS activity may be related to their poor performance. PMID: 30043387 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 24, 2018 Category: Sleep Medicine Authors: Crescimanno G, Greco F, Arrisicato S, Marrone O Tags: Sleep Breath Source Type: research

Reliability of autonomic activations as surrogates of cortical arousals in ventilated patients affected by amyotrophic lateral sclerosis
ConclusionsIn ventilated ALS patients, autonomic activations may hardly have a role as surrogates of cortical arousals for assessment of sleep fragmentation and for respiratory scoring. Depression of ANS activity may be related to their poor performance. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 24, 2018 Category: Respiratory Medicine Source Type: research

Aortic root size is associated with nocturnal blood pressure in a population of hypertensive patients under treatment for obstructive sleep apnea
AbstractBackgroundObstructive sleep apnea (OSA) is associated with an increased aortic root size. This association has never been studied in patients with hypertension undergoing continuous positive airway pressure (CPAP) treatment for OSA.MethodsThe 24-h blood pressure (BP) monitoring of 142 hypertensive patients undergoing CPAP treatment for OSA was prospectively documented. Aortic root diameter was assessed by echocardiography.ResultsThe population included 33.8% women, with an overall mean age of 60.7  ± 10.5 years. The median body mass index was 32.7 [29. 5–36.3] kg/m2. The median ...
Source: Sleep and Breathing - July 24, 2018 Category: Respiratory Medicine Source Type: research

Abstracts of the 9th International Sleep Surgical Society Meeting, 5-7th April 2018, Munich, Germany.
Authors: PMID: 30039350 [PubMed] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 23, 2018 Category: Sleep Medicine Tags: Sleep Breath Source Type: research

Abstracts of the 9th International Sleep Surgical Society Meeting, 5 –7th April 2018, Munich, Germany
(Source: Sleep and Breathing)
Source: Sleep and Breathing - July 23, 2018 Category: Respiratory Medicine Source Type: research

Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians.
CONCLUSION: NAFLD is an additional risk factor in OSA subject which contributes to systemic inflammation in Asian Indians. PMID: 30032465 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 22, 2018 Category: Sleep Medicine Authors: Bhatt SP, Guleria R, Vikram NK, Gupta AK Tags: Sleep Breath Source Type: research

Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians
ConclusionNAFLD is an additional risk factor in OSA subject which contributes to systemic inflammation in Asian Indians. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 22, 2018 Category: Respiratory Medicine Source Type: research

Smartphone-based delivery of oropharyngeal exercises for treatment of snoring: a randomized controlled trial.
CONCLUSIONS: Smartphone application-administered upper airway training reduces objective and subjective snoring measures and improves sleep quality. TRIAL REGISTRATION: ClinicalTrials.gov ; no.: NCT03264963; URL: www.clinicaltrials.gov. PMID: 30032464 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 21, 2018 Category: Sleep Medicine Authors: Goswami U, Black A, Krohn B, Meyers W, Iber C Tags: Sleep Breath Source Type: research

Smartphone-based delivery of oropharyngeal exercises for treatment of snoring: a randomized controlled trial
ConclusionsSmartphone application-administered upper airway training reduces objective and subjective snoring measures and improves sleep quality.Trial registrationClinicalTrials.gov; no.: NCT03264963; URL:www.clinicaltrials.gov (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 21, 2018 Category: Respiratory Medicine Source Type: research

Sleep quality in survivors of critical illness.
CONCLUSIONS: Survivors of critical illness exhibited a high prevalence of obstructive sleep-disordered breathing and poor sleep architecture at hospital discharge, which slightly improved 6 months later, indicating that reversible factors are partly responsible for these abnormalities. PMID: 30030695 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 20, 2018 Category: Sleep Medicine Authors: Alexopoulou C, Bolaki M, Akoumianaki E, Erimaki S, Kondili E, Mitsias P, Georgopoulos D Tags: Sleep Breath Source Type: research

Sleep quality in survivors of critical illness
ConclusionsSurvivors of critical illness exhibited a high prevalence of obstructive sleep-disordered breathing and poor sleep architecture at hospital discharge, which slightly improved 6  months later, indicating that reversible factors are partly responsible for these abnormalities. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 20, 2018 Category: Respiratory Medicine Source Type: research

Dental Sleep Medicine redefined.
PMID: 30027526 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 19, 2018 Category: Sleep Medicine Authors: Aarab G, Lobbezoo F Tags: Sleep Breath Source Type: research

Dental Sleep Medicine redefined
(Source: Sleep and Breathing)
Source: Sleep and Breathing - July 19, 2018 Category: Respiratory Medicine Source Type: research

Obstructive sleep apnea negatively impacts objectively measured physical activity.
CONCLUSION: Individuals screened as likely possessing OSA were less physically active than individuals without OSA when measured through objective means. We found no group differences in daytime sleepiness, BMI, or percent fat, suggesting other mechanisms than obesity and sleepiness for this difference. PMID: 30022324 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 18, 2018 Category: Sleep Medicine Authors: Hargens TA, Martin RA, Strosnider CL, Giersch GEW, Womack CJ Tags: Sleep Breath Source Type: research

Noncontact identification of sleep-disturbed breathing from smartphone-recorded sounds validated by polysomnography.
CONCLUSIONS: Ambient sounds recorded from a smartphone during sleep can identify apnea and abnormal breathing verified on PSG. Future studies should determine if this approach may facilitate early screening of SDB to identify at-risk patients for definitive diagnosis and therapy. CLINICAL TRIALS: NCT03288376; clinicaltrials.org. PMID: 30022325 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 18, 2018 Category: Sleep Medicine Authors: Narayan S, Shivdare P, Niranjan T, Williams K, Freudman J, Sehra R Tags: Sleep Breath Source Type: research

Noncontact identification of sleep-disturbed breathing from smartphone-recorded sounds validated by polysomnography
ConclusionsAmbient sounds recorded from a smartphone during sleep can identify apnea and abnormal breathing verified on PSG. Future studies should determine if this approach may facilitate early screening of SDB to identify at-risk patients for definitive diagnosis and therapy.Clinical trialsNCT03288376;clinicaltrials.org (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 18, 2018 Category: Respiratory Medicine Source Type: research

Obstructive sleep apnea negatively impacts objectively measured physical activity
ConclusionIndividuals screened as likely possessing OSA were less physically active than individuals without OSA when measured through objective means. We found no group differences in daytime sleepiness, BMI, or percent fat, suggesting other mechanisms than obesity and sleepiness for this difference. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 18, 2018 Category: Respiratory Medicine Source Type: research

Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea.
CONCLUSION: IL10RB, MAPK9, MAPK10, and TXN might function in the pathogenesis of OSA. PMID: 29992456 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 10, 2018 Category: Sleep Medicine Authors: Gu X, Yang W, Luo X, Wang X, Tang J, Cai Z Tags: Sleep Breath Source Type: research

Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea
ConclusionIL10RB,MAPK9,MAPK10, andTXN might function in the pathogenesis of OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 10, 2018 Category: Respiratory Medicine Source Type: research

The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis.
Abstract BACKGROUND: Obstructive sleep apnea hypopnea syndrome (OSAHS) means apnea and hypopnea caused by partial or complete obstruction of upper airway collapse during sleep. Gastroesophageal reflux disease (GERD) is believed to be associated with various manifestations in the otorhinolaryngology and has been found to be an additional risk factor for OSAHS. AIM: A meta-analysis was performed to identify the association between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease. METHODS: To identify eligible original articles, we searched a series of computerized databases, in...
Source: Sleep and Breathing - July 9, 2018 Category: Sleep Medicine Authors: Wu ZH, Yang XP, Niu X, Xiao XY, Chen X Tags: Sleep Breath Source Type: research

The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis
AbstractBackgroundObstructive sleep apnea hypopnea syndrome (OSAHS) means apnea and hypopnea caused by partial or complete obstruction of upper airway collapse during sleep. Gastroesophageal reflux disease (GERD) is believed to be associated with various manifestations in the otorhinolaryngology and has been found to be an additional risk factor for OSAHS.AimA meta-analysis was performed to identify the association between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease.MethodsTo identify eligible original articles, we searched a series of computerized databases, including Medline via PubMed, ...
Source: Sleep and Breathing - July 9, 2018 Category: Respiratory Medicine Source Type: research

Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study.
Abstract PURPOSE: To assess the association between obstructive sleep apnea (OSA) and gallstones. METHODS: We identified 3827 patients aged ≥ 20 years with OSA between 2000 and 2010 from the Longitudinal Health Insurance Research Database 2000 (LHID2000) as the study cohort. The beneficiaries without OSA were randomly selected and propensity-matched with the study cohort in a 1:1 ratio according to age; sex; occupation; urbanization; comorbidities of hypothyroidism, hyperlipidemia, diabetes, liver cirrhosis, alcohol-related illness, hypertension, chronic obstructive pulmonary disease (COPD), ob...
Source: Sleep and Breathing - July 7, 2018 Category: Sleep Medicine Authors: Chen CH, Lin CL, Hsu CY, Kao CH Tags: Sleep Breath Source Type: research

Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study
AbstractPurposeTo assess the association between obstructive sleep apnea (OSA) and gallstones.MethodsWe identified 3827 patients aged ≥ 20 years with OSA between 2000 and 2010 from the Longitudinal Health Insurance Research Database 2000 (LHID2000) as the study cohort. The beneficiaries without OSA were randomly selected and propensity-matched with the study cohort in a 1:1 ratio according to age; sex; occupation; urbanizatio n; comorbidities of hypothyroidism, hyperlipidemia, diabetes, liver cirrhosis, alcohol-related illness, hypertension, chronic obstructive pulmonary disease (COPD), obesity, inflammatory...
Source: Sleep and Breathing - July 7, 2018 Category: Respiratory Medicine Source Type: research

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome
ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 2, 2018 Category: Respiratory Medicine Source Type: research

Association between insomnia and type 2 diabetes mellitus in Han Chinese individuals in Shandong Province, China.
CONCLUSIONS: This study suggests that insomnia is independently and significantly associated with diabetes mellitus in the northern Chinese population, especially in the 40-59-year-old age group and in males. PMID: 29961182 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 30, 2018 Category: Sleep Medicine Authors: Zhang Y, Lin Y, Zhang J, Li L, Liu X, Wang T, Gao Z Tags: Sleep Breath Source Type: research

Association between insomnia and type 2 diabetes mellitus in Han Chinese individuals in Shandong Province, China
ConclusionsThis study suggests that insomnia is independently and significantly associated with diabetes mellitus in the northern Chinese population, especially in the 40 –59-year-old age group and in males. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 30, 2018 Category: Respiratory Medicine Source Type: research

Association between insomnia and job stress: a meta-analysis.
Abstract PURPOSE: Insomnia has become one of the foremost health concerns among workers. Despite a significant number of epidemiological studies have reported on the correlation between insomnia and job stress, comprehensive evidence remains insufficient. Therefore, this research seeks to provide evidence with greater reliability, through summarizing relevant contemporary literature via a meta-analysis. METHODS: Literature from across Europe and Asia that was of both a prospective and cross-sectional design was included, if well-controlled odds ratios were available. The meta-analysis was undertaken in accord...
Source: Sleep and Breathing - June 29, 2018 Category: Sleep Medicine Authors: Yang B, Wang Y, Cui F, Huang T, Sheng P, Shi T, Huang C, Lan Y, Huang YN Tags: Sleep Breath Source Type: research

Improved follow-up by peripheral arterial tonometry in CPAP-treated patients with obstructive sleep apnea and persistent excessive daytime sleepiness.
CONCLUSION: PAT could detect significantly more residual SDB under CPAP treatment than 6Ch-PM. Diagnostic work-up of CPAP-treated OSA patients with persistent EDS might be optimized, as insufficient pressure level adjustments could be recognized more precisely in time, possibly preventing more resource-consuming procedures, and potentially increased morbidity. CLINICAL TRIAL REGISTRATION: DRKS00007705. PMID: 29956104 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 29, 2018 Category: Sleep Medicine Authors: Schöbel C, Knorre S, Glos M, Garcia C, Fietze I, Penzel T Tags: Sleep Breath Source Type: research

Association between insomnia and job stress: a meta-analysis
AbstractPurposeInsomnia has become one of the foremost health concerns among workers. Despite a significant number of epidemiological studies have reported on the correlation between insomnia and job stress, comprehensive evidence remains insufficient. Therefore, this research seeks to provide evidence with greater reliability, through summarizing relevant contemporary literature via a meta-analysis.MethodsLiterature from across Europe and Asia that was of both a prospective and cross-sectional design was included, if well-controlled odds ratios were available. The meta-analysis was undertaken in accordance with the guidel...
Source: Sleep and Breathing - June 29, 2018 Category: Respiratory Medicine Source Type: research

Improved follow-up by peripheral arterial tonometry in CPAP-treated patients with obstructive sleep apnea and persistent excessive daytime sleepiness
ConclusionPAT could detect significantly more residual SDB under CPAP treatment than 6Ch-PM. Diagnostic work-up of CPAP-treated OSA patients with persistent EDS might be optimized, as insufficient pressure level adjustments could be recognized more precisely in time, possibly preventing more resource-consuming procedures, and potentially increased morbidity.Clinical trial registrationDRKS00007705 (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 29, 2018 Category: Respiratory Medicine Source Type: research

Patient experience with upper airway stimulation in the treatment of obstructive sleep apnea.
CONCLUSION: This investigation on the sUAS therapy revealed a high adherence to the therapy. The AHI or daytime sleepiness do not have obvious influence on adherence. Patients expressed a positive attitude towards sUAS. These patient reports upon stimulation experiences are of great help to consult candidates for sUAS in future. PMID: 29956103 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 28, 2018 Category: Sleep Medicine Authors: Hofauer B, Steffen A, Knopf A, Hasselbacher K, Heiser C Tags: Sleep Breath Source Type: research

Patient experience with upper airway stimulation in the treatment of obstructive sleep apnea
ConclusionThis investigation on the sUAS therapy revealed a high adherence to the therapy. The AHI or daytime sleepiness do not have obvious influence on adherence. Patients expressed a positive attitude towards sUAS. These patient reports upon stimulation experiences are of great help to consult candidates for sUAS in future. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 28, 2018 Category: Respiratory Medicine Source Type: research

Metoprolol has a similar therapeutic effect as amlodipine on BP lowering in hypertensive patients with obstructive sleep apnea.
CONCLUSIONS: Metoprolol had similar therapeutic effects on BP lowering as amlodipine and could not decrease HR during the nighttime in hypertensive patients with OSA. PMID: 29951886 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 27, 2018 Category: Sleep Medicine Authors: Shi J, Yuan Y, Deng X, Pan Y, He M, Liu G, Sun D, Wang J, Wang W, Li Y Tags: Sleep Breath Source Type: research

Metoprolol has a similar therapeutic effect as amlodipine on BP lowering in hypertensive patients with obstructive sleep apnea
ConclusionsMetoprolol had similar therapeutic effects on BP lowering as amlodipine and could not decrease HR during the nighttime in hypertensive patients with OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 27, 2018 Category: Respiratory Medicine Source Type: research

A French update on the Self-Efficacy Measure for Sleep Apnea (SEMSA) to assess continuous positive airway pressure (CPAP) use.
CONCLUSIONS: The French version of the SEMSA is a psychometrically acceptable self-report questionnaire for measuring health beliefs and behavior in French patients with OSAS treated with CPAP. Such translation and validation should lead to the adoption of validated psychosocial methods for improving CPAP use. PMID: 29946945 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 26, 2018 Category: Sleep Medicine Authors: Micoulaud-Franchi JA, Coste O, Bioulac S, Guichard K, Monteyrol PJ, Ghorayeb I, Weaver TE, Weibel S, Philip P Tags: Sleep Breath Source Type: research

Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study.
CONCLUSIONS: In this sample of older subjects, PWV is not affected by AHI and ODI but was associated with incident hypertension. These results may suggest potential protective and adaptive mechanisms in older sleep apnea patients. CLINICAL TRIAL REGISTRATIONS: NCT 00759304 and NCT 00766584 . PMID: 29946946 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 26, 2018 Category: Sleep Medicine Authors: Sforza E, Millasseau S, Hupin D, Barthélémy JC, Roche F Tags: Sleep Breath Source Type: research

Serum levels of NGAL and cystatin C as markers of early kidney dysfunction in patients with obstructive sleep apnea syndrome.
Abstract PURPOSE: Obstructive sleep apnea syndrome (OSAS) has been recently proposed as an independent risk factor for chronic kidney disease. Cystatin C (Cyst C) and neutrophil gelatinase-associated lipocalin (NGAL) are novel biomarkers for the earlier detection of latent kidney disease. The aim of the study was to assess serum Cyst C and NGAL levels in otherwise healthy OSAS patients and to explore possible associations with sleep parameters. METHODS: Consecutive subjects (n = 96, 79.2% males), without known comorbidities, with symptoms suggestive of OSAS were included. All of them underwent p...
Source: Sleep and Breathing - June 26, 2018 Category: Sleep Medicine Authors: Voulgaris A, Archontogeorgis K, Nena E, Tsigalou C, Xanthoudaki M, Kouratzi M, Tripsianis G, Froudarakis M, Steiropoulos P Tags: Sleep Breath Source Type: research