MRI measurement of blood-brain barrier leakage: filling the gaps.
PMID: 30520035 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 6, 2018 Category: Physiology Authors: Thrippleton MJ Tags: J Physiol Source Type: research

Na+ /H+ exchanger type-1: a shepherd for cellular transhumance.
PMID: 30516282 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 5, 2018 Category: Physiology Authors: Roger S Tags: J Physiol Source Type: research

Histone demethylase UTX is a therapeutic target for diabetic kidney disease.
This article is protected by copyright. All rights reserved. PMID: 30516825 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 5, 2018 Category: Physiology Authors: Chen H, Huang Y, Zhu X, Liu C, Yuan Y, Su H, Zhang C, Liu C, Xiong M, Qu Y, Yun P, Zheng L, Huang K Tags: J Physiol Source Type: research

Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
This study using cell type-specific Myf5-cre;Lipin1fl/fl conditional knockout mice (Lipin1Myf5cKO ) shows that lipin1 is a major determinant of SM development. Lipin1 deficiency induced reduced muscle mass and myopathy. Our results from lipin1-deficient myoblasts suggested that lipin1 regulates myoblast differentiation through the protein kinase Cμ (PKCμ)/histone deacetylase 5 (HDAC5)/myocyte-specific enhancer factor 2C (MEF2c):MyoD-mediated pathway. Lipin1 deficiency leads to the suppression of PKC isoform activities, as well as the inhibition of the downstream target of PKCμ, class II deacetylase HDAC5 nuclear e...
Source: The Journal of Physiology - December 4, 2018 Category: Physiology Authors: Jama A, Huang D, Alshudukhi AAA, Chrast R, Ren H Tags: J Physiol Source Type: research

Human Brain Blood Flow and Metabolism During Isocapnic Hyperoxia: The Role of Reactive Oxygen Species.
This article is protected by copyright. All rights reserved. PMID: 30506968 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 3, 2018 Category: Physiology Authors: Mattos JD, Campos MO, Rocha MP, Mansur DE, Rocha HNM, Garcia VP, Batista G, Alvares TS, Oliveira GV, Souza MV, Videira RLR, Rocha NG, Secher NH, Nóbrega ACL, Fernandes IA Tags: J Physiol Source Type: research

Seven consecutive days of remote ischaemic preconditioning improves cutaneous vasodilatory capacity in young adults.
Abstract KEY POINTS: Remote ischaemic preconditioning (RIPC), induced by brief bouts of ischaemia followed by reperfusion, confers vascular adaptations that protect against subsequent bouts of ischaemia. However, the effect of RIPC repeated over several days on the human microcirculation is unknown. Using skin as a model, microvascular function was assessed at a control and a NO-inhibited area of skin before, after, and 1 week after administering seven consecutive days of repeated RIPC on the contralateral arm. Maximal vasodilatation was increased by ∼20-50% following seven days of repeated RIPC, and this...
Source: The Journal of Physiology - December 2, 2018 Category: Physiology Authors: Lang JA, Kim J, Franke WD, Vianna LC Tags: J Physiol Source Type: research

Transient downregulation of BDNF is required for GABAergic maturation in rat primary visual cortex: Review of: Zhang H, Mu L, Wang D, Xia D, Salmon A, Liu Q & Wong-Riley MTT (2018). Uncovering a critical period of synaptic imbalance during postnatal development of the rat visual cortex: role of brain-derived neurotrophic factor. J Physiol 596, 4511-4536.
Transient downregulation of BDNF is required for GABAergic maturation in rat primary visual cortex: Review of: Zhang H, Mu L, Wang D, Xia D, Salmon A, Liu Q & Wong-Riley MTT (2018). Uncovering a critical period of synaptic imbalance during postnatal development of the rat visual cortex: role of brain-derived neurotrophic factor. J Physiol 596, 4511-4536. J Physiol. 2018 Dec 01;: Authors: Buchan MJ PMID: 30506569 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 1, 2018 Category: Physiology Authors: Buchan MJ Tags: J Physiol Source Type: research

Amplification of endothelium-dependent vasodilatation in contracting human skeletal muscle: role of KIR channels.
This study is the first in humans to demonstrate that specific endothelium-dependent vasodilatory signalling is amplified in the vasculature of contracting skeletal muscle and that KIR channels may serve as amplifiers of EDH-like vasodilatory signalling in humans. ABSTRACT: The local vasodilatory response to muscle contraction is due in part to the activation of inwardly rectifying potassium (KIR ) channels. Evidence from animal models suggest that KIR channels function as "amplifiers" of endothelium-dependent vasodilators. We tested the hypothesis that contracting muscle selectively amplifies endothelium-de...
Source: The Journal of Physiology - December 1, 2018 Category: Physiology Authors: Hearon CM, Richards JC, Racine ML, Luckasen GJ, Larson DG, Dinenno FA Tags: J Physiol Source Type: research

Challenges and controversies in perinatal physiology.
PMID: 30499159 [PubMed - in process] (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 1, 2018 Category: Physiology Authors: Bennet L, Ikeda T, Llanos AJ, Nijhuis J, Gunn AJ Tags: J Physiol Source Type: research

Rebuttal from Sally H. Vitali.
PMID: 30499158 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 29, 2018 Category: Physiology Authors: Vitali SH Tags: J Physiol Source Type: research

Rebuttal from Krishna C. Penumatsa, Rod R. Warburton, Nicholas S. Hill and Barry L. Fanburg.
PMID: 30499182 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 29, 2018 Category: Physiology Authors: Penumatsa KC, Warburton RR, Hill NS, Fanburg BL Tags: J Physiol Source Type: research

CrossTalk opposing view: The mouse SuHx model is not a good model of pulmonary arterial hypertension.
PMID: 30499185 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 29, 2018 Category: Physiology Authors: Vitali SH Tags: J Physiol Source Type: research

CrossTalk proposal: The mouse SuHx model is a good model of pulmonary arterial hypertension.
PMID: 30499212 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 29, 2018 Category: Physiology Authors: Penumatsa KC, Warburton RR, Hill NS, Fanburg BL Tags: J Physiol Source Type: research

Calcineurin/AKAP interactions: therapeutic targeting of a pleiotropic enzyme with a little help from its friends.
This article is protected by copyright. All rights reserved. PMID: 30488951 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 29, 2018 Category: Physiology Authors: Gildart M, Kapiloff MS, Dodge-Kafka KL Tags: J Physiol Source Type: research

Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation.
In conclusion, Src inhibition causes phosphorylation of S269 independently of pS256, and induces AQP2 membrane accumulation by inhibiting clathrin-mediated endocytosis and increasing exocytosis. We conclude that S269 can be phosphorylated without pS256, and pS269 alone is important for AQP2 apical membrane accumulation under some conditions. These data increase our understanding of the independent pathways that can phosphorylate different residues in the AQP2 c-terminus, and suggest new strategies to target distinct AQP2 serine residues to induce membrane expression of this water channel when VP signaling is defective. Thi...
Source: The Journal of Physiology - November 28, 2018 Category: Physiology Authors: Cheung PW, Terlouw A, Janssen SA, Brown D, Bouley R Tags: J Physiol Source Type: research

Oxygen is rocket fuel for the human brain; a radical perspective!
PMID: 30488438 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 28, 2018 Category: Physiology Authors: Bailey DM Tags: J Physiol Source Type: research

The role of submaximal exercise-induced skeletal muscle remodeling in HFrEF patients.
PMID: 30488441 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 28, 2018 Category: Physiology Authors: Engineer A, Albers SS, Kucey AS Tags: J Physiol Source Type: research

Sleep disordered breathing in children disrupts the maturation of autonomic control of heart rate and its association with cerebral oxygenation.
Conclusion SDB disrupts the normal maturation of the autonomic control of heart rate and the association between HRV and cerebral oxygenation exhibited by non-snoring control children of primary school age. These results highlight the impact SDB has on cardiovascular control and the potential impact on adverse cardiovascular outcomes. This article is protected by copyright. All rights reserved. PMID: 30471111 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 24, 2018 Category: Physiology Authors: Walter LM, Tamanyan K, Weichard AJ, Davey MJ, Nixon GM, Horne RS Tags: J Physiol Source Type: research

The Na+ /H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration.
This article is protected by copyright. All rights reserved. PMID: 30471113 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 24, 2018 Category: Physiology Authors: Jensen HH, Pedersen GA, Morgen JJ, Parsons M, Pedersen SF, Nejsum LN Tags: J Physiol Source Type: research

Challenges and advances in atomistic simulations of potassium and sodium Ion channel gating and permeation.
This article is protected by copyright. All rights reserved. PMID: 30471114 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 24, 2018 Category: Physiology Authors: DeMarco KR, Bekker S, Vorobyov I Tags: J Physiol Source Type: research

Modularity in the intact and spinal cat: methods, issues and questions for the future.
Abstract The paper of Etienne Desrochers and colleagues in the Frigon lab (Desrochers et al., this volume) is an important contribution. They provide a clear demonstration of a synergy organization in the spinal cord of the cat that is closely similar before and after spinal transection, using the methods of Krouchev and colleagues (2006) of 'Direct Component Analysis' (DCA). PMID: 30466139 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 22, 2018 Category: Physiology Authors: Giszter SF Tags: J Physiol Source Type: research

A new coupling of an acid-base transporter to PKD and cyst formation.
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a devastating disease that affects millions of people, and often leads to renal failure, kidney dialysis, and transplantation (Ghata & Cowley Jr, 2017). PMID: 30466184 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 22, 2018 Category: Physiology Authors: Bevensee MO Tags: J Physiol Source Type: research

Metabolic remodeling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice.
This article is protected by copyright. All rights reserved. PMID: 30462352 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 21, 2018 Category: Physiology Authors: Cortassa S, Caceres V, Tocchetti CG, Bernier M, de Cabo R, Paolocci N, Sollott SJ, Aon MA Tags: J Physiol Source Type: research

Simulation of P2X-mediated calcium signaling in microglia.
This article is protected by copyright. All rights reserved. PMID: 30462840 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 21, 2018 Category: Physiology Authors: Chun B, Stewart BD, Vaughan DD, Bachstetter AD, Kekenes-Huskey PM Tags: J Physiol Source Type: research

The shear complexity of insulin-stimulated vasodilation.
PMID: 30447000 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 17, 2018 Category: Physiology Authors: Lalande S, Romero SA Tags: J Physiol Source Type: research

Classic solutions to a modern problem: Exercise training improves metabolic disorders in offspring from fathers on a high fat diet.
PMID: 30431645 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 15, 2018 Category: Physiology Authors: Kelly AC, Limesand SW Tags: J Physiol Source Type: research

Ih contributes to increased motoneuron excitability in restless legs syndrome.
This article is protected by copyright. All rights reserved. PMID: 30430565 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 14, 2018 Category: Physiology Authors: Czesnik D, Howells J, Bartl M, Veiz E, Ketzler R, Kemmet O, Walters AS, Trenkwalder C, Burke D, Paulus W Tags: J Physiol Source Type: research

The relationships and interactions between age, exercise and physiological function.
This article is protected by copyright. All rights reserved. PMID: 30422311 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 13, 2018 Category: Physiology Authors: Lazarus NR, Lord JM, Harridge SDR Tags: J Physiol Source Type: research

Spinal plasticity with motor imagery practice.
This article is protected by copyright. All rights reserved. PMID: 30417924 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 12, 2018 Category: Physiology Authors: Grosprêtre S, Lebon F, Papaxanthis C, Martin A Tags: J Physiol Source Type: research

Blood-brain barrier permeability measured using dynamic contrast-enhanced magnetic resonance imaging: a validation study.
Conclusions Ki behaves as expected for a compound marker of permeability and surface area. The GM/WM CBV ratio measured by this technique is in agreement with the literature. This adds evidence to the validity of Ki measured by DCE-MRI as a marker of overall BBB leakage. This article is protected by copyright. All rights reserved. PMID: 30417928 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 12, 2018 Category: Physiology Authors: Varatharaj A, Liljeroth M, Darekar A, Larsson HBW, Galea I, Cramer SP Tags: J Physiol Source Type: research

GABAB receptors modulate Ca2+ but not G protein-gated inwardly rectifying K+ channels in cerebrospinal-fluid contacting neurones of mouse brainstem.
This article is protected by copyright. All rights reserved. PMID: 30418666 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 12, 2018 Category: Physiology Authors: Jurčić N, Er-Raoui G, Airault C, Trouslard J, Wanaverbecq N, Seddik R Tags: J Physiol Source Type: research

Physical inactivity induced insulin resistance: Could alterations to the vasculature be to blame?
PMID: 30414182 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 10, 2018 Category: Physiology Authors: Frye J, Clayton ZS Tags: J Physiol Source Type: research

Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals.
This article is protected by copyright. All rights reserved. PMID: 30414190 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 10, 2018 Category: Physiology Authors: Park S, Turner KD, Zheng D, Brault JJ, Zou K, Chaves AB, Nielsen TS, Tanner CJ, Treebak JT, Houmard JA Tags: J Physiol Source Type: research

3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes.
This article is protected by copyright. All rights reserved. PMID: 30412283 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 9, 2018 Category: Physiology Authors: Shen X, Brink JVD, Hou Y, Colli D, Le C, Kolstad TR, MacQuaide N, Carlson CR, Kekenes-Huskey PM, Edwards AG, Soeller C, Louch WE Tags: J Physiol Source Type: research

Action potential shortening rescues atrial calcium alternans.
This study investigates whether pharmacological manipulation of AP morphology is a viable strategy to reduces the risk of arrhythmogenic CaT alternans. Pacing-induced AP and CaT alternans were studied in rabbit atrial myocytes using combined Ca2+ imaging and electrophysiological measurements. Increased AP duration (APD) and beat-to-beat alternations in AP morphology lowered the pacing frequency threshold and increased the degree of CaT alternans. Inhibition of Ca2+ -activated Cl- channels reduced beat-to-beat AP alternations, but prolonged APD and failed to suppress CaT alternans. In contrast, AP shortening induced by acti...
Source: The Journal of Physiology - November 9, 2018 Category: Physiology Authors: Kanaporis G, Kalik ZM, Blatter LA Tags: J Physiol Source Type: research

Exendin-4 Overcomes Cytokine-Induced Decreases in Gap Junction Coupling via PKA and Epac2 in Mouse and Human Islets.
This article is protected by copyright. All rights reserved. PMID: 30412665 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 9, 2018 Category: Physiology Authors: Farnsworth NL, Walter R, Piscopio R, Schleicher WE, Benninger RKP Tags: J Physiol Source Type: research

Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet.
We examined whether only 4 weeks of exercise early in life could reprogram these negative effects. Male Sprague-Dawley rats consumed a HFD for 10 weeks before mating with chow-fed dams. Female offspring remained sedentary or performed moderate intensity treadmill exercise (5 days/week, 60 min/day, 20 m/min) from 5 to 9 weeks of age. Paternal HFD impaired (P
Source: The Journal of Physiology - November 8, 2018 Category: Physiology Authors: Falcão-Tebas F, Kuang J, Arceri C, Kerris JP, Andrikopoulos S, Marin EC, McConell GK Tags: J Physiol Source Type: research

Structural mechanisms for defective CFTR gating caused by the Q1412X mutation, a severe Class VI pathogenic mutation in cystic fibrosis.
This article is protected by copyright. All rights reserved. PMID: 30408177 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 8, 2018 Category: Physiology Authors: Yeh JT, Yu YC, Hwang TC Tags: J Physiol Source Type: research

Potential cellular and energetic mechanisms for age-related differences in skeletal muscle fatigue.
This article is protected by copyright. All rights reserved. PMID: 30408194 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 8, 2018 Category: Physiology Authors: Foster A, Fitzgerald L, Bartlett M, Straight C Tags: J Physiol Source Type: research

Exaggerated systemic oxidative-nitrosative-inflammatory stress in chronic mountain sickness is associated with cognitive decline and depression.
We examined if exaggerated oxidative-nitrosative-inflammatory stress (OXINOS) and corresponding decrease in vascular nitric oxide bioavailability in patients with CMS (CMS+) is associated with impaired cerebrovascular function and adverse neurological outcome. Systemic OXINOS was markedly elevated in CMS+ compared to healthy HA (CMS-) and low-altitude controls. OXINOS was associated with blunted cerebral perfusion and vasoreactivity to hypercapnia, impaired cognition and in CMS+, symptoms of depression. These findings are the first to suggest that a physiological continuum exists for hypoxaemia-induced systemic OXINOS in H...
Source: The Journal of Physiology - November 5, 2018 Category: Physiology Authors: Bailey DM, Brugniaux JV, Filipponi T, Marley C, Stacey B, Soria R, Rimoldi SF, Cerny D, Rexhaj E, Pratali L, Salmòn CS, Jáuregui CM, Villena M, Smirl JD, Shigehiko O, Pietri S, Scherrer U, Md CS Tags: J Physiol Source Type: research

Once is enough for acute exercise benefits on insulin sensitivity.
PMID: 30394533 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 5, 2018 Category: Physiology Authors: Cartee GD Tags: J Physiol Source Type: research

Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.
This article is protected by copyright. All rights reserved. PMID: 30390415 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 3, 2018 Category: Physiology Authors: Greenspon CM, Battell EE, Devonshire IM, Donaldson LF, Chapman V, Hathway GJ Tags: J Physiol Source Type: research

Uncoupling a unique couple by chopping off one of its tails in the KATP channels of the heart and pancreas.
PMID: 30387493 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 2, 2018 Category: Physiology Authors: Luppi P, Drain P Tags: J Physiol Source Type: research

Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.
This article is protected by copyright. All rights reserved. PMID: 30382582 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 1, 2018 Category: Physiology Authors: Kono M, Kakegawa W, Yoshida K, Yuzaki M Tags: J Physiol Source Type: research

PKC δ constrains the S-pathway to phrenic motor facilitation elicited by spinal 5-HT7 receptors or severe acute intermittent hypoxia​.
This article is protected by copyright. All rights reserved. PMID: 30382587 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 1, 2018 Category: Physiology Authors: Perim RR, Fields DP, Mitchell GS Tags: J Physiol Source Type: research

If serotonin does not exhaust you, it makes you stronger.
PMID: 30382591 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 1, 2018 Category: Physiology Authors: Perrier JF Tags: J Physiol Source Type: research

ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain.
This article is protected by copyright. All rights reserved. PMID: 30382595 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 1, 2018 Category: Physiology Authors: Bulla M, Gyimesi G, Kim JH, Bhardwaj R, Hediger MA, Frieden M, Demaurex N Tags: J Physiol Source Type: research

The impact of 2-years of high intensity exercise training on a model of integrated cardiovascular regulation.
CONCLUSIONS: In these previously sedentary, otherwise healthy middle-aged adults, a 2-year program of high-intensity exercise training improved integrated cardiovascular regulation by enhancing the dynamic Starling mechanism and arterial-cardiac baroreflex sensitivity, without changing dynamic arterial elastance. This article is protected by copyright. All rights reserved. PMID: 30387144 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 1, 2018 Category: Physiology Authors: Hieda M, Howden EJ, Sarma S, Cornwell W, Lawley JS, Tarumi T, Palmer D, Samels M, Everding B, Livingston S, Fu Q, Zhang R, Levine BD Tags: J Physiol Source Type: research

SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding.
Abstract KEY POINTS: Maternal high-fat diet (MHF) consumption led to metabolic and liver disorders in male offspring, which are associated with reduced sirtuin (SIRT)1 expression and activity in the offspring liver SIRT1 overexpression in MHF offspring reduced their body weight and adiposity and normalized lipid metabolic markers in epididymal and retroperitoneal adipose tissues SIRT1 overexpression in MHF offspring improved glucose tolerance, as well as systemic and hepatic insulin sensitivity SIRT1 overexpression ameliorated MHF-induced lipogenesis, oxidative stress and fibrogenesis in the liver of offspring. ...
Source: The Journal of Physiology - October 31, 2018 Category: Physiology Authors: Nguyen LT, Chen H, Zaky A, Pollock C, Saad S Tags: J Physiol Source Type: research

Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function.
This article is protected by copyright. All rights reserved. PMID: 30379325 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - October 31, 2018 Category: Physiology Authors: Oparija L, Rajendran A, Poncet N, Verrey F Tags: J Physiol Source Type: research