Evidence that distinct human primary motor cortex circuits control discrete and rhythmic movements.
This article is protected by copyright. All rights reserved. PMID: 32057108 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 14, 2020 Category: Physiology Authors: Wiegel P, Kurz A, Leukel C Tags: J Physiol Source Type: research

Response to Lamb and Stephenson.
PMID: 32058587 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 14, 2020 Category: Physiology Authors: Bailey SJ, Gandra PG, Jones AM, Hogan MC, Nogueira L Tags: J Physiol Source Type: research

With hemoglobin as with politics-should we shift right or left?
PMID: 32052863 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Dempsey JA Tags: J Physiol Source Type: research

Heat treatment improves the exaggerated exercise pressor reflex in rats with femoral artery occlusion via a reduction in the activity of the P2X receptor pathway.
In conclusion, prior heat exposure plays an inhibitory role in modifying the exaggeration of the exercise pressor reflex in PAD and a reduction of the activity of the P2X receptor pathway is likely a part of mechanisms leading to the beneficial effects of HT. This article is protected by copyright. All rights reserved. PMID: 32052864 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Qin L, Li Q, Li J Tags: J Physiol Source Type: research

The microenvironment matters: The secret life of intramuscular lipid droplets.
PMID: 32052866 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Chow LS, Mashek DG Tags: J Physiol Source Type: research

Rebuttal from Gr égoire P. Millet and Tadej Debevec.
Rebuttal from Grégoire P. Millet and Tadej Debevec. J Physiol. 2020 Feb 13;: Authors: Millet GP, Debevec T PMID: 32053210 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Millet GP, Debevec T Tags: J Physiol Source Type: research

TRPM2 and biliary acute pancreatitis.
PMID: 32053213 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Bruce JIE Tags: J Physiol Source Type: research

Rebuttal from Jean-Paul Richalet.
PMID: 32053225 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Richalet JP Tags: J Physiol Source Type: research

CrossTalk opposing view: Barometric pressure, independent of P O 2 , is not the forgotten parameter in altitude physiology and mountain medicine.
CrossTalk opposing view: Barometric pressure, independent of P O 2 , is not the forgotten parameter in altitude physiology and mountain medicine. J Physiol. 2020 Feb 13;: Authors: Richalet JP PMID: 32053235 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Richalet JP Tags: J Physiol Source Type: research

CrossTalk proposal: Barometric pressure, independent of P O 2 , is the forgotten parameter in altitude physiology and mountain medicine.
CrossTalk proposal: Barometric pressure, independent of P O 2 , is the forgotten parameter in altitude physiology and mountain medicine. J Physiol. 2020 Feb 13;: Authors: Millet GP, Debevec T PMID: 32053239 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 13, 2020 Category: Physiology Authors: Millet GP, Debevec T Tags: J Physiol Source Type: research

Oxidative ATP synthesis in human quadriceps declines during 4 minutes of maximal contractions.
This article is protected by copyright. All rights reserved. PMID: 32045011 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 11, 2020 Category: Physiology Authors: Bartlett MF, Fitzgerald LF, Nagarajan R, Hiroi Y, Kent JA Tags: J Physiol Source Type: research

Complexity of cathodal tDCS: Relevance of stimulation repetition, interval, and intensity.
PMID: 32045019 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 11, 2020 Category: Physiology Authors: Salehinejad MA, Ghanavati E Tags: J Physiol Source Type: research

Neuropsychological and neurophysiological aspects of brain-computer-interface (BCI)-control in paralysis.
This article is protected by copyright. All rights reserved. PMID: 32045022 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 11, 2020 Category: Physiology Authors: Chaudhary U, Mrachacz-Kersting N, Birbaumer N Tags: J Physiol Source Type: research

Direct translation of findings in isolated animal preparations to in vivo human motoneuron behaviour is challenging.
PMID: 32031678 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 7, 2020 Category: Physiology Authors: Del Vecchio A, Negro F, Holobar A, Casolo A, Folland JP, Felici F, Farina D Tags: J Physiol Source Type: research

Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?
This article is protected by copyright. All rights reserved. PMID: 32034761 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 7, 2020 Category: Physiology Authors: Shaw JE, Koleske AJ Tags: J Physiol Source Type: research

Neuronal HIF-1 α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia.
Neuronal HIF-1α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia. J Physiol. 2020 Feb 06;: Authors: Moya EA, Go A, Kim CB, Fu Z, Simonson TS, Powell FL Abstract KEY POINTS: We hypothesized that hypoxia inducible factor 1α (HIF-1α) in central nervous system (CNS) respiratory centers is necessary for ventilatory acclimatization to hypoxia (VAH); VAH is a time-dependent increase in baseline ventilation and the hypoxic ventilatory response (HVR) occurring over days to weeks of chronic sustained hypoxia (CH). Constitutive deletion of HIF-1α in ...
Source: The Journal of Physiology - February 6, 2020 Category: Physiology Authors: Moya EA, Go A, Kim CB, Fu Z, Simonson TS, Powell FL Tags: J Physiol Source Type: research

Delayed metabolic dysfunction in myocardium following exertional heat stroke in mice.
This article is protected by copyright. All rights reserved. PMID: 32026469 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 5, 2020 Category: Physiology Authors: Laitano O, Garcia CK, Mattingly AJ, Robinson GP, Murray KO, King MA, Ingram B, Ramamoorthy S, Leon LR, Clanton TL Tags: J Physiol Source Type: research

Loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait.
sta C Abstract KEY POINTS: Individuals with freezing of gait (FoG) due to Parkinson's disease (PD) have small and long anticipatory postural adjustments (APA) associated with delayed step initiation. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs due to supraspinal dysfunction. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, it may be deficient in freezers during APAs. We show that freezers presented PSI in quiet stance (control task), but they presented loss of PSI (i.e. higher ratio of the conditi...
Source: The Journal of Physiology - February 5, 2020 Category: Physiology Authors: Lira JLO, Ugrinowitsch C, Coelho DB, Teixeira LA, de Lima-Pardini AC, Magalhães FH, Barbosa ER, Horak FB, Silva-Batista C Tags: J Physiol Source Type: research

Correction of z-motion artefacts to allow population imaging of synaptic activity in behaving mice.
This article is protected by copyright. All rights reserved. PMID: 32020615 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 5, 2020 Category: Physiology Authors: Ryan T, Hinojosa AJ, Vroman R, Papasavvas C, Lagnado L Tags: J Physiol Source Type: research

Intermittent hypoxia and sympathetic activation: To constrict or not to constrict, that is the question.
PMID: 32022925 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 5, 2020 Category: Physiology Authors: Jacob DW, Mascone SE Tags: J Physiol Source Type: research

How motoneurones control velocity of tension development.
PMID: 32010982 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Baldissera F, Campadelli P, Cavallari P, Piccinelli L, Tesio L Tags: J Physiol Source Type: research

Serotonin modulates optimized coding of natural stimuli through increased neural and behavioral responses via enhanced burst firing.
This article is protected by copyright. All rights reserved. PMID: 32011728 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Marquez MM, Chacron MJ Tags: J Physiol Source Type: research

Improved neural control of body temperature following heat acclimation in humans.
This study tested the hypothesis that heat acclimation improves the neural control of body temperature. Body temperatures, skin sympathetic nerve activity, cutaneous vasodilation, and sweat production were measured in 14 healthy adults (9 men/5 women, 27 ± 5 years) during passive heat stress performed before and after a 7-day heat acclimation protocol. Heat acclimation increased whole-body sweat rate (+0.54 L/h [0.32, 0.75], P 
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Barry H, Chaseling GK, Moreault S, Sauvageau C, Behzadi P, Gravel H, Ravanelli N, Gagnon D Tags: J Physiol Source Type: research

Cold water immersion puts the chill on muscle protein synthesis after resistance exercise.
PMID: 32012269 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Chaillou T, Treigyte V Tags: J Physiol Source Type: research

Cation-chloride cotransporters and the polarity of GABA signalling in mouse hippocampal parvalbumin interneurons.
This article is protected by copyright. All rights reserved. PMID: 32012273 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Otsu Y, Donneger F, Schwartz EJ, Poncer JC Tags: J Physiol Source Type: research

Impaired skeletal muscle performance as a consequence of random functional capillary rarefaction can be restored with overload-dependent angiogenesis.
Abstract KEY POINTS: Loss of skeletal muscle capillaries is thought to contribute to a reduction in exercise tolerance but the relative contribution of a compromised microcirculation with disease, in isolation of co-morbidities, to impaired muscle function is unknown. We have therefore developed a novel method to randomly occlude capillaries in the rat hindlimb to mimic the capillary rarefaction observed in many conditions. We demonstrate that muscle fatigue resistance is closely coupled with functional microvascular density, independent of arterial blood flow while, disturbance of the microcirculation leads to lo...
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Tickle PG, Hendrickse PW, Degens H, Egginton S Tags: J Physiol Source Type: research

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+ binding and cause misfolding.
This study focuses on understanding the structural characteristics of CaM disease mutants and their interactions with the calcium channel. Arrhythmia mutations in CaM can lead to loss of Ca2+ binding, uncoupling of Ca2+ binding cooperativity, misfolding of the EF-hands, and altered affinity for the calcium channel. These results help us to understand how different CaM mutants have distinct effects on structure and interactions with protein targets to cause disease. ABSTRACT: Calmodulinopathies are life-threatening arrhythmia syndromes that arise from mutations in calmodulin (CaM), a calcium sensing protein whose seque...
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Wang K, Brohus M, Holt C, Overgaard MT, Wimmer R, Van Petegem F Tags: J Physiol Source Type: research

Guiding synaptic plasticity: Novel roles for netrin-1 in synaptic plasticity and memory formation in the adult brain.
This article is protected by copyright. All rights reserved. PMID: 32017127 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 3, 2020 Category: Physiology Authors: Glasgow SD, Ruthazer ES, Kennedy TE Tags: J Physiol Source Type: research

Mental health disorders: Prevalent but widely ignored in academia?
r A PMID: 32003870 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 31, 2020 Category: Physiology Authors: Müller A Tags: J Physiol Source Type: research

Impaired muscle spindle function in murine models of muscular dystrophy.
This article is protected by copyright. All rights reserved. PMID: 32003874 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 31, 2020 Category: Physiology Authors: Gerwin L, Rossmanith S, Haupt C, Schultheiß J, Brinkmeier H, Bittner RE, Kröger S Tags: J Physiol Source Type: research

AMPA receptor structure and auxiliary subunits.
This article is protected by copyright. All rights reserved. PMID: 32004381 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 31, 2020 Category: Physiology Authors: Kamalova A, Nakagawa T Tags: J Physiol Source Type: research

Special issue: Mechanics and energetics in cardiac arrhythmias and heart failure.
PMID: 31998965 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 30, 2020 Category: Physiology Authors: Bers DM, Kohl P, Chen-Izu Y Tags: J Physiol Source Type: research

Effect of nitrite on Ca2+ movements and fatigue in muscle.
PMID: 32000297 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 30, 2020 Category: Physiology Authors: Lamb GD, Stephenson DG Tags: J Physiol Source Type: research

Complementing cooling: the ongoing search for an effective adjunct to therapeutic hypothermia.
PMID: 31994725 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 29, 2020 Category: Physiology Authors: Baburamani AA, Arichi T Tags: J Physiol Source Type: research

Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease.
PMID: 31994730 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 29, 2020 Category: Physiology Authors: Munro ML, Jones PP Tags: J Physiol Source Type: research

Glutamate receptors from diverse animal species exhibit unexpected structural and functional diversity.
This article is protected by copyright. All rights reserved. PMID: 31981421 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 25, 2020 Category: Physiology Authors: Mayer ML Tags: J Physiol Source Type: research

The role of vascular function on exercise capacity in health and disease.
This article is protected by copyright. All rights reserved. PMID: 31977068 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 24, 2020 Category: Physiology Authors: Poole DC, Behnke BJ, Musch TI Tags: J Physiol Source Type: research

Evidence for a physiological role of pulmonary arterial baroreceptors in sympathetic neural activation in healthy humans.
Abstract KEY POINTS: In an anaesthetized animal model, independent stimulation of baroreceptors in the pulmonary artery elicits reflex sympathoexcitation. In humans, pulmonary arterial pressure is positively related to basal MSNA under conditions where elevated pulmonary pressure is evident (e.g. high-altitude); however, a causal link is not established. Using a novel experimental approach, we demonstrate that reducing pulmonary arterial pressure lowers basal MSNA in healthy humans. This response is distinct from the negative feedback reflex mediated by aortic and carotid sinus baroreceptors when systemic arterial...
Source: The Journal of Physiology - January 24, 2020 Category: Physiology Authors: Simpson LL, Meah VL, Steele A, Thapamagar S, Gasho C, Anholm JD, Drane AL, Dawkins TG, Busch SA, Oliver SJ, Lawley JS, Tymko MM, Ainslie PN, Steinback CD, Stembridge M, Moore JP Tags: J Physiol Source Type: research

Relationship between cardiorespiratory phase coherence during hypoxia and genetic polymorphism in humans.
This article is protected by copyright. All rights reserved. PMID: 31957891 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 20, 2020 Category: Physiology Authors: Lancaster G, Debevec T, Millet GP, Poussel M, Willis SJ, Mramor M, Goričar K, Osredkar D, Dolžan V, Stefanovska A Tags: J Physiol Source Type: research

A high-fat high-calorie diet induces fibre-specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle.
This study measured the effect of 7 days HFHC diet on: 1) skeletal muscle concentration of lipid metabolites, and 2) potential changes in the perilipin (PLIN) content of the lipid droplets (LD) storing IMTG. The HFHC diet increased PLIN3 protein expression and redistributed PLIN2 to LD stores in type I fibres. The HFHC diet increased IMTG content in type I fibres, while lipid metabolite concentrations remained the same. The data suggest that the increases in IMTG stores assists reducing the accumulation of lipid metabolites known to contribute to skeletal muscle insulin resistance. ABSTRACT: A HFHC diet reduces whole ...
Source: The Journal of Physiology - January 20, 2020 Category: Physiology Authors: Whytock KL, Parry SA, Turner MC, Woods RM, James LJ, Ferguson RA, Ståhlman M, Borén J, Strauss JA, Cocks M, Wagenmakers AJM, Hulston CJ, Shepherd SO Tags: J Physiol Source Type: research

δ-subunit containing GABAA IPSCs are driven by both synaptic and diffusional GABA in mouse dentate granule neurons.
This article is protected by copyright. All rights reserved. PMID: 31951019 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 17, 2020 Category: Physiology Authors: Sun MY, Ziolkowski L, Mennerick S Tags: J Physiol Source Type: research

Integration of energy homeostasis and stress by parvocellular neurons in rat hypothalamic paraventricular nucleus.
This article is protected by copyright. All rights reserved. PMID: 31952096 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 17, 2020 Category: Physiology Authors: Melnick I, Krishtal OA, Colmers WF Tags: J Physiol Source Type: research

Intake versus output: The evolving role of diet in exercise-dependent skeletal muscle signalling and bone remodelling.
PMID: 31944294 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 16, 2020 Category: Physiology Authors: Kucey AS, Fahey CJ, Kirkham TM, Engineer A, Albers SS Tags: J Physiol Source Type: research

Activation of endogenous protein phosphatase 1 enhances the calcium sensitivity of the ryanodine receptor type 2 in murine ventricular cardiomyocytes.
This article is protected by copyright. All rights reserved. PMID: 31943206 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 15, 2020 Category: Physiology Authors: Potenza DM, Janicek R, Fernandez-Tenorio M, Niggli E Tags: J Physiol Source Type: research

The role of extracellular vesicles in skeletal muscle and systematic adaption to exercise.
This article is protected by copyright. All rights reserved. PMID: 31944292 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 15, 2020 Category: Physiology Authors: Vechetti IJ, Valentino T, Mobley CB, McCarthy JJ Tags: J Physiol Source Type: research

Different coding strategy of sound information between GABAergic and glutamatergic neurons in the auditory midbrain.
This article is protected by copyright. All rights reserved. PMID: 31943205 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 14, 2020 Category: Physiology Authors: Ito T Tags: J Physiol Source Type: research

Fractal spike dynamics and neuronal coupling in the primate visual system.
Abstract KEY POINTS: We measured fractal (self-similar) fluctuations in ongoing spiking activity in subcortical (lateral geniculate nucleus, LGN) and cortical (area MT) visual areas in anaesthetised marmosets. Cells in the evolutionary ancient koniocellular LGN pathway and in area MT show high-amplitude fractal fluctuations, whereas evolutionary newer parvocellular and magnocellular LGN cells do not. Spiking activity in koniocellular cells and MT cells shows substantial correlation to the local population activity, whereas activity in parvocellular and magnocellular cells is less correlated with local activity. We...
Source: The Journal of Physiology - January 13, 2020 Category: Physiology Authors: Munn B, Zeater N, Pietersen AN, Solomon SG, Cheong SK, Martin PR, Gong P Tags: J Physiol Source Type: research

A nod to gut-brain signalling. Nod-like receptors are critical for gut-brain axis signalling in mice.
PMID: 31925784 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 10, 2020 Category: Physiology Authors: Tavolieri MV, Young SD, Bitzan M Tags: J Physiol Source Type: research

Ribosome biogenesis and resistance training volume in human skeletal muscle.
PMID: 31922607 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 10, 2020 Category: Physiology Authors: Solsona R, Sanchez AM Tags: J Physiol Source Type: research

Exploring the infinite parameter space: Rethinking assumptions underpinning the use of transcranial direct current stimulation to induce long-term effects.
PMID: 31922623 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 10, 2020 Category: Physiology Authors: Stagg CJ Tags: J Physiol Source Type: research