Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway.
This article is protected by copyright. All rights reserved. PMID: 32939754 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 16, 2020 Category: Physiology Authors: Small L, Altıntaş A, Laker RC, Ehrlich A, Pattamaprapanont P, Villarroel J, Pillon NJ, Zierath JR, Barrès R Tags: J Physiol Source Type: research

Performance of ion chromatography to measure picomoles of magnesium in nanoliter samples.
In conclusion, ultra high performance liquid chromatography is suitable for measurement of picomoles of magnesium in renal tubular fluid. The method allows detailed studies of transepithelial magnesium transport across native epithelium. This article is protected by copyright. All rights reserved. PMID: 32936928 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 16, 2020 Category: Physiology Authors: Figueres L, Prot-Bertoye C, Morla L, Ferriere E, Griveau C, Brideau G, Baron S, Houillier P Tags: J Physiol Source Type: research

Studying t-tubular functionality in mechanically skinned fibres to understand the mechanism of muscle fatigue.
PMID: 32936938 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 16, 2020 Category: Physiology Authors: Renaud JM Tags: J Physiol Source Type: research

How far have we reached? Perhaps not enough, new avenues are about to be traveled.
PMID: 32936961 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 16, 2020 Category: Physiology Authors: Rocha MP Tags: J Physiol Source Type: research

Acute activation of bronchopulmonary vagal nociceptors by type I interferons.
This article is protected by copyright. All rights reserved. PMID: 32924209 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 14, 2020 Category: Physiology Authors: Patil MJ, Ru F, Sun H, Wang J, Kolbeck R, Dong X, Kollarik M, Canning BJ, Undem BJ Tags: J Physiol Source Type: research

Bursting mitral cells time the oscillatory coupling between olfactory bulb and entorhinal networks in neonatal mice.
This article is protected by copyright. All rights reserved. PMID: 32926437 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 14, 2020 Category: Physiology Authors: Kostka JK, Gretenkord S, Spehr M, Hanganu-Opatz IL Tags: J Physiol Source Type: research

August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data.
ard L Abstract August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism (1906) and overturning the concept of active transport of gases across the pulmonary epithelium (1910). Despite this, at the beginning of 1920, the consummate experimentalist was relatively unknown worldwide and even among his own University of Copenhagen faculty. But, in early 1919, he had submitted three papers to Dr Langley, then editor of The Journal of Physiology in England. These papers coalesced anatomical observations of skeletal muscle capillary numbers with O2 diffusion theory to propose a novel act...
Source: The Journal of Physiology - September 12, 2020 Category: Physiology Authors: Poole DC, Pittman RN, Musch TI, Østergaard L Tags: J Physiol Source Type: research

Simulated shift work during pregnancy does not impair progeny metabolic outcomes in sheep.
This article is protected by copyright. All rights reserved. PMID: 32918750 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 12, 2020 Category: Physiology Authors: Gatford KL, Kennaway DJ, Liu H, Schultz CG, Wooldridge AL, Kuchel TR, Varcoe TJ Tags: J Physiol Source Type: research

The insulin-sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres.
In conclusion, the insulin-sensitizing effect of a single bout of exercise includes both type I and type II fibres in human skeletal muscle. This may be an important observation for future pharmacological strategies targeting muscle insulin sensitivity in humans. This article is protected by copyright. All rights reserved. PMID: 32916040 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 11, 2020 Category: Physiology Authors: Larsen MR, Steenberg DE, Birk JB, Sjøberg KA, Kiens B, Richter EA, Wojtaszewski JFP Tags: J Physiol Source Type: research

Internal carotid and brachial artery shear-dependent vasodilator function in young healthy humans.
This study compared internal carotid artery (ICA) and brachial artery (BA) endothelium-dependent and -independent vasodilation. We hypothesized that endothelium-dependent and -independent vasodilation of the ICA and BA would be neither similar in magnitude nor correlated between vessels. In 19 healthy adults (23±6 years, 24±3 kg/m2 , 6 female), endothelium-dependent dilation in the ICA was determined via Duplex ultrasound during transiently elevated shear stress caused by increased partial pressure of end-tidal carbon dioxide using dynamic end-tidal forcing (+9mmHg; cerebral flow-mediated dilation, cFMD)...
Source: The Journal of Physiology - September 9, 2020 Category: Physiology Authors: Carr JMJR, Hoiland RL, Caldwell HG, Coombs GB, Howe CA, Tremblay JC, Green DJ, Ainslie PN Tags: J Physiol Source Type: research

TRPV1 channel as the membrane Vitamin D receptor: solving parts of the puzzle.
PMID: 32897545 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 8, 2020 Category: Physiology Authors: Tripathy B, Majhi RK Tags: J Physiol Source Type: research

To model or not to model - the physiologist's dilemma.
PMID: 32897585 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 8, 2020 Category: Physiology Authors: Wilson CG Tags: J Physiol Source Type: research

Rapamycin and mTORC2 inhibition synergistically reduce contraction-stimulated muscle protein synthesis.
This article is protected by copyright. All rights reserved. PMID: 32893874 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 7, 2020 Category: Physiology Authors: Ogasawara R, Knudsen JR, Li J, Ato S, Jensen TE Tags: J Physiol Source Type: research

Functional, proteomic, and bioinformatic analyses of Nrf2- and Keap1- null skeletal muscle.
In conclusion, we found that Nrf2 targeted proteins are assigned into two groups: one mediates the tonic effects evoked by a low level of Nrf2 at basal condition; the other is responsible for the inducible effects evoked by a surge of Nrf2 that is dependent on a Keap1 mechanism. This article is protected by copyright. All rights reserved. PMID: 32893883 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 7, 2020 Category: Physiology Authors: Gao L, Kumar V, Vellichirammal NN, Park SY, Rudebush TL, Yu L, Son WM, Pekas EJ, Wafi AM, Hong J, Xiao P, Guda C, Wang HJ, Schultz HD, Zucker IH Tags: J Physiol Source Type: research

Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure.
Abstract KEY POINTS: Heart failure patients with reduced ejection fraction (HFrEF) exhibit severe limitations in exercise capacity (V̇O2 peak). One of the primary peripheral mechanisms suggested to underlie exercise intolerance in HFrEF is excessive locomotor muscle group III/IV afferent feedback; however, this has never been investigated in human HF. HFrEF patients and controls performed an incremental exercise test to volitional exhaustion to determine V̇O2 peak with lumbar intrathecal fentanyl or placebo. During exercise, cardiac output, leg blood flow, and radial artery and femoral venous blood gases were me...
Source: The Journal of Physiology - September 4, 2020 Category: Physiology Authors: Smith JR, Joyner MJ, Curry TB, Borlaug BA, Keller-Ross ML, Van Iterson EH, Olson TP Tags: J Physiol Source Type: research

Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes.
This article is protected by copyright. All rights reserved. PMID: 32886797 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 4, 2020 Category: Physiology Authors: Mahalingam S, Cheviron ZA, Storz JF, McClelland GB, Scott GR Tags: J Physiol Source Type: research

Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons.
This article is protected by copyright. All rights reserved. PMID: 32886798 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 4, 2020 Category: Physiology Authors: Godfrey N, Borgland SL Tags: J Physiol Source Type: research

Ex-vivo electroretinograms made easy: performing ERGs using 3D printed components.
This article is protected by copyright. All rights reserved. PMID: 32886799 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 4, 2020 Category: Physiology Authors: Bonezzi PJ, Tarchick MJ, Renna JM Tags: J Physiol Source Type: research

Breaking it down: the metabolism of neurotransmitters in the colonic wall.
PMID: 32886800 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 4, 2020 Category: Physiology Authors: Fung C, Berghe PV Tags: J Physiol Source Type: research

Abnormal placental CD8+ T cell infiltration is a feature of fetal growth restriction and pre-eclampsia.
In conclusion, FGR and pre-eclampsia are associated with T-cell infiltration of the placenta and placental pathological abnormalities. This article is protected by copyright. All rights reserved. PMID: 32886802 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 4, 2020 Category: Physiology Authors: Lager S, Sovio U, Eddershaw E, van der Linden MW, Yazar C, Cook E, Happerfield L, Jessop FA, Sebire NJ, Charnock-Jones DS, Smith GCS Tags: J Physiol Source Type: research

Neurovascular coupling: sending this signal here, hope you pick it up loud and clear.
PMID: 32869875 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 1, 2020 Category: Physiology Authors: Faraci FM Tags: J Physiol Source Type: research

Rebuttal from Francisco J. Alvarez-Leefmans.
PMID: 32870502 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 1, 2020 Category: Physiology Authors: Alvarez-Leefmans FJ Tags: J Physiol Source Type: research

Rebuttal from Nanna MacAulay and Christine R. Rose.
PMID: 32870504 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 1, 2020 Category: Physiology Authors: MacAulay N, Rose CR Tags: J Physiol Source Type: research

CrossTalk opposing view: NKCC1 in the luminal membrane of choroid plexus is outwardly directed under basal conditions and contributes directly to cerebrospinal fluid secretion.
PMID: 32870507 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 1, 2020 Category: Physiology Authors: MacAulay N, Rose CR Tags: J Physiol Source Type: research

CrossTalk proposal: Apical NKCC1 of choroid plexus epithelial cells works in the net inward flux mode under basal conditions, maintaining intracellular Cl- and cell volume.
PMID: 32870510 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 1, 2020 Category: Physiology Authors: Alvarez-Leefmans FJ Tags: J Physiol Source Type: research

Functional architecture of the motor homunculus detected by electrostimulation.
Abstract KEY POINTS: We performed a prospective electrostimulation study of the motor homunculus in 100 patients without motor deficit or brain lesion in the precentral gyrus in order to acquire accurate MNI coordinates of the functional areas. The analysis of 248 body coordinates in the precentral gyrus showed rare inter-individual variations in the medial-to-lateral somatotopic movement organization with quite similar intensity thresholds. Electrostimulation only induced basic and stereotyped movements. We detected a relative medial-to-lateral somatotopy of the wrist/hand/global/individual fingers, with sometime...
Source: The Journal of Physiology - August 28, 2020 Category: Physiology Authors: Roux FE, Niare M, Charni S, Giussani C, Durand JB Tags: J Physiol Source Type: research

A subpopulation of L6b neurons provide driver-like input to the posteromedial thalamus.
PMID: 32857864 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 28, 2020 Category: Physiology Authors: Buchan MJ Tags: J Physiol Source Type: research

Temporally-precise basolateral amygdala activation is required for the formation of taste memories in gustatory cortex.
This article is protected by copyright. All rights reserved. PMID: 32857870 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 28, 2020 Category: Physiology Authors: Arieli E, Gerbi R, Shein-Idelson M, Moran A Tags: J Physiol Source Type: research

Determinants of renal oxygen metabolism during low Na+ diet: effect of angiotensin II AT1 and aldosterone receptor blockade.
This article is protected by copyright. All rights reserved. PMID: 32857872 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 28, 2020 Category: Physiology Authors: Patinha D, Carvalho C, Persson P, Pihl L, Fasching A, Friederich-Persson M, O'Neill J, Palm F Tags: J Physiol Source Type: research

Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels.
Abstract KEY POINTS: Temporal lobe epilepsy is a complex neurological disease caused by imbalance of excitation and inhibition in the brain. Growing literature implicates altered Ca2+ signalling in many aspects of epilepsy but the precise Ca2+ channels that regulate this syndrome are not clear. Here, we report that mice lacking the store-operated Ca2+ channel, Orai1, in the brain show markedly stronger seizures in response to the chemoconvulsants, kainic acid and pilocarpine. Electrophysiological analysis reveals that selective deletion of Orai1 channels in inhibitory neurons disables chemoconvulsant-induced excit...
Source: The Journal of Physiology - August 27, 2020 Category: Physiology Authors: Hori K, Tsujikawa S, Novakovic MM, Yamashita M, Prakriya M Tags: J Physiol Source Type: research

Emerging views of how changes in T3 influence prenatal metabolic maturation.
PMID: 32851657 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 27, 2020 Category: Physiology Authors: Patel E, Smith R Tags: J Physiol Source Type: research

Spinal motoneuron firing properties mature from rostral to caudal during post-natal development of the mouse.
This article is protected by copyright. All rights reserved. PMID: 32851667 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 27, 2020 Category: Physiology Authors: Smith CC, Brownstone RM Tags: J Physiol Source Type: research

August Krogh: Physiology genius and compassionate humanitarian.
ard L PMID: 32853399 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 27, 2020 Category: Physiology Authors: Poole DC, Pittman RN, Musch TI, Østergaard L Tags: J Physiol Source Type: research

Charged residues at the pore extracellular half of the glycine receptor facilitate channel gating: a potential role played by electrostatic repulsion.
This study, by employing function and computation methods, proposes that charged residues (including the Arg residue) at the pore extracellular half from each of the five subunits of the homomeric α1 GlyR, create an electrostatic repulsive potential to widen the pore, thereby facilitating channel opening. This mechanism explains how the Arg271Gln mutation, in which the positively charged Arg residue is substituted by the neutral Gln residue, compromises GlyR function. This study furthers our understanding of the biophysical mechanism underlying the Arg271Gln mutation compromising GlyR function. ABSTRACT: The R27...
Source: The Journal of Physiology - August 26, 2020 Category: Physiology Authors: Tian Y, Chen S, Shan Q Tags: J Physiol Source Type: research

Insulin-stimulated glucose uptake partly relies on p21-activated kinase 2 (PAK2), but not PAK1, in mouse skeletal muscle.
EA, Sylow L Abstract KEY POINTS: Muscle-specific genetic ablation of PAK2, but not whole-body PAK1 knockout, impairs glucose tolerance in mice Insulin-stimulated glucose uptake partly relies on PAK2 in glycolytic EDL muscle Contrasting previous reports, PAK1 is dispensable for insulin-stimulated glucose uptake in mouse muscle ABSTRACT: The group I p21-activated kinase (PAK) isoforms PAK1 and PAK2 are activated in response to insulin in skeletal muscle and PAK1/2 signalling is impaired in insulin-resistant mouse and human skeletal muscle. Interestingly, PAK1 has been suggested to be required for insulin-s...
Source: The Journal of Physiology - August 26, 2020 Category: Physiology Authors: Møller LLV, Jaurji M, Kjøbsted R, Joseph GA, Madsen AB, Knudsen JR, Lundsgaard AM, Andersen NR, Schjerling P, Jensen TE, Krauss RS, Richter EA, Sylow L Tags: J Physiol Source Type: research

Tissue-specific deletion of mouse basolateral uniporter LAT4 (Slc43a2) reveals its crucial role in small intestine and kidney amino acid transport.
This article is protected by copyright. All rights reserved. PMID: 32841365 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 25, 2020 Category: Physiology Authors: Rajendran A, Poncet N, Oparija-Rogenmozere L, Herzog B, Verrey F Tags: J Physiol Source Type: research

Tracking the motion of KV 1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy.
This article is protected by copyright. All rights reserved. PMID: 32833227 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 24, 2020 Category: Physiology Authors: Pantazis A, Kaneko M, Angelini M, Steccanella F, Westerlund AM, Lindström SH, Nilsson M, Delemotte L, Saitta SC, Olcese R Tags: J Physiol Source Type: research

Good things come in small packages …except after spinal injury.
Good things come in small packages…except after spinal injury. J Physiol. 2020 Aug 24;: Authors: Bolser DC PMID: 32833267 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 24, 2020 Category: Physiology Authors: Bolser DC Tags: J Physiol Source Type: research

Fatigue-induced change in T-system excitability and its major cause in rat fast-twitch skeletal muscle in vivo.
In conclusion, T-system excitability is decreased after high-intensity exercise due at least in part to the S-glutathionylation of Na+-K+ ATPase, which may be enhanced by contraction-induced ATP depression. ABSTRACT: The purpose of this study was to investigate a transverse tubular system (T-system) excitability after skeletal muscle contractions in vivo, and the contribution of S-glutathionylation of Na+ -K+ ATPase. T-system excitability was estimated by measuring repriming period (RP) required for double action potentials in mechanically-skinned fibres where the sarcolemma was removed but T-system still works. The R...
Source: The Journal of Physiology - August 24, 2020 Category: Physiology Authors: Watanabe D, Wada M Tags: J Physiol Source Type: research

Distinct features of calcium handling and β-adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction.
This article is protected by copyright. All rights reserved. PMID: 32829489 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 23, 2020 Category: Physiology Authors: Kilfoil PJ, Lotteau S, Zhang R, Yue X, Aynaszyan S, Solymani RE, Cingolani E, Marbán E, Goldhaber JI Tags: J Physiol Source Type: research

Do you take the highway or the back-roads? Understanding bilateral connectivity in patients with Chronic Obstructive Pulmonary Disease (COPD).
PMID: 32829496 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 23, 2020 Category: Physiology Authors: Hendy AM Tags: J Physiol Source Type: research

Oxidative stress in the medullary respiratory neurons contributes to the respiratory dysfunction in the 6-OHDA model of Parkinson's disease.
This article is protected by copyright. All rights reserved. PMID: 32820824 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 21, 2020 Category: Physiology Authors: Falquetto B, Thieme K, Malta MB, E Rocha KC, Tuppy M, Potje SR, Antoniali C, Rodrigues AC, Munhoz CD, Moreira TS, Takakura AC Tags: J Physiol Source Type: research

Preventative therapeutic approaches for hypertrophic cardiomyopathy.
This article is protected by copyright. All rights reserved. PMID: 32822065 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 21, 2020 Category: Physiology Authors: Solomon T, Filipovska A, Hool L, Viola H Tags: J Physiol Source Type: research

Influence of age on the frequency characteristics of the soleus muscle response to Achilles tendon vibration during standing.
This article is protected by copyright. All rights reserved. PMID: 32822066 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 21, 2020 Category: Physiology Authors: Mildren RL, Schmidt ME, Eschelmuller G, Carpenter MG, Blouin JS, Inglis JT Tags: J Physiol Source Type: research

Lift, stop, rest, repeat: The potential of 'cluster sets' as interval resistance exercise for COPD.
PMID: 32818291 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 20, 2020 Category: Physiology Authors: Latella C Tags: J Physiol Source Type: research

Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2'-deoxy-ATP.
This study of the dATP induced changes in myosin may be instructive for determining the structural changes desired for other potential myosin targeted molecular compounds to treat muscle diseases. ABSTRACT: Here we used time-resolved small angle X-ray diffraction coupled with force measurements to study the structural changes in FVB mouse skeletal muscle sarcomeres during relaxation after tetanus contraction. To estimate the rate of myosin deactivation we followed the rate of the intensity recovery of the first-order myosin layer line (MLL1) and the restoration of the resting spacing of the third and sixth order of me...
Source: The Journal of Physiology - August 20, 2020 Category: Physiology Authors: Ma W, Childers M, Murray J, Moussavi-Harami F, Gong H, Weiss R, Daggett V, Irving T, Regnier M Tags: J Physiol Source Type: research

Loss of variable fascicle gearing during voluntary isometric contractions of paretic medial gastrocnemius muscles in male chronic stroke survivors.
This study aims to understand variable fascicle gearing during voluntary isometric contractions of the medial gastrocnemius (MG) muscle in chronic stroke survivors. Using ultrasonography, we characterized fascicle behaviour on both paretic and non-paretic sides during plantarflexion contractions at different intensities and at different ankle joint angles. Shear wave speed was also recorded from the MG muscle belly under passive conditions. Fascicle gear ratios were then calculated as the ratio of muscle belly shortening velocity to fascicle shortening velocity, and variable fascicle gearing was quantified from the slope o...
Source: The Journal of Physiology - August 20, 2020 Category: Physiology Authors: Son J, Rymer WZ Tags: J Physiol Source Type: research

Synaptic competition: 'to be or not to be' the calyx of Held?
PMID: 32809213 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 18, 2020 Category: Physiology Authors: Tawfik B, Wang LY Tags: J Physiol Source Type: research

Preconditioning human pharyngeal motor cortex enhances directional metaplasticity induced by repetitive transcranial magnetic stimulation.
Abstract KEY POINTS: Recent studies have proposed therapeutic potential for repetitive transcranial magnetic stimulation (rTMS) in swallowing rehabilitation, yet its outcomes vary across individuals and studies. Such variability may be related to the brain state before stimulation. Metaplasticity is a higher order plasticity which regulates cortical response to plasticity changes. Studies have shown that preconditioning of the hand motor cortex could increase cortical capacity for neuroplastic change and enhance rTMS outcomes. We investigated, for the first time, the directional metaplastic properties in human pha...
Source: The Journal of Physiology - August 17, 2020 Category: Physiology Authors: Cheng I, Scarlett H, Zhang M, Hamdy S Tags: J Physiol Source Type: research

Vascular ATP-sensitive K+ channels support maximal aerobic capacity and critical speed via convective and diffusive O2 transport.
Abstract KEY POINTS: Oral sulphonylureas, widely prescribed in diabetes, inhibit pancreatic ATP-sensitive K+ (KATP ) channels to increase insulin release. However, KATP channels are also located within vascular (endothelium and smooth muscle) and muscle (cardiac and skeletal) tissue. We evaluated left ventricular function at rest, maximal aerobic capacity (V̇O2 max) and submaximal exercise tolerance (i.e. speed-duration relationship) during treadmill running in rats, before and after systemic KATP channel inhibition via glibenclamide. Glibenclamide impaired critical speed proportionally more than V̇O2 max but di...
Source: The Journal of Physiology - August 14, 2020 Category: Physiology Authors: Colburn TD, Weber RE, Hageman KS, Caldwell JT, Schulze KM, Ade CJ, Behnke BJ, Poole DC, Musch TI Tags: J Physiol Source Type: research