Spinal cord-level adaptations to resistance training: the 'backbone' of early strength gains?
PMID: 31004445 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 20, 2019 Category: Physiology Authors: Fyfe JJ, Hamilton DL Tags: J Physiol Source Type: research

Intermittent hypoxia impairs uterine artery function in pregnant mice.
Abstract KEY POINTS: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Using a mouse model of intermittent hypoxia, we evaluated main uterine artery function, spiral artery remodelling, circulating angiogenic and anti-angiogenic factors, and placental hypoxia and oxidative stress at gestational day 14...
Source: The Journal of Physiology - April 19, 2019 Category: Physiology Authors: Badran M, Abuyassin B, Ayas N, Laher I Tags: J Physiol Source Type: research

Enhancement of excitatory transmission in NTS neurons projecting to ventral medulla of rats exposed to sustained hypoxia is blunted by minocycline.
This article is protected by copyright. All rights reserved. PMID: 30993693 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 17, 2019 Category: Physiology Authors: Lima-Silveira L, Accorsi-Mendonça D, Bonagamba LGH, Almado CEL, da Silva MP, Nedoboy PE, Pilowsky PM, Machado BH Tags: J Physiol Source Type: research

The role of estrogen in left ventricle (re)modelling in the context of heart failure with preserved ejection fraction.
PMID: 30993694 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 16, 2019 Category: Physiology Authors: Hadipour-Lakmehsari S, Mouaswas SA Tags: J Physiol Source Type: research

Studies into the determinants of skeletal muscle oxygen consumption: Novel insight from near-infrared diffuse correlation spectroscopy.
This article is protected by copyright. All rights reserved. PMID: 30982990 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 14, 2019 Category: Physiology Authors: Tucker WJ, Rosenberry R, Trojacek D, Chamseddine HH, Arena-Marshall CA, Zhu Y, Wang J, Kellawan JM, Haykowsky MJ, Tian F, Nelson MD Tags: J Physiol Source Type: research

Cross Talk Final Reply.
Authors: PMID: 30980402 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 13, 2019 Category: Physiology Tags: J Physiol Source Type: research

Morphing mitochondria: Understanding the development of the mitochondrial reticulum in skeletal muscle.
PMID: 30980403 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2019 Category: Physiology Authors: Ryan TE Tags: J Physiol Source Type: research

Intercellular calcium waves integrate hormonal control of glucose output in the intact liver.
This article is protected by copyright. All rights reserved. PMID: 30968953 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 10, 2019 Category: Physiology Authors: Gaspers LD, Pierobon N, Thomas AP Tags: J Physiol Source Type: research

TRIC-A channels rock out alone while TRIC-B get high with a little help from their friends.
PMID: 30968955 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 10, 2019 Category: Physiology Authors: Copello JA Tags: J Physiol Source Type: research

Calcified, top secretion only: epithelial repair in gastric organoid requires calcium mobilization.
PMID: 30968957 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 10, 2019 Category: Physiology Authors: Cho CJ, Mills JC Tags: J Physiol Source Type: research

Molecular basis of allosteric Orai1 channel activation by STIM1.
Abstract Store-operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry in many cells and mediates a variety of cellular effector functions ranging from gene transcription to exocytosis. Orai1 channels are amongst the most Ca2+ selective channels known and are activated by direct physical interactions with the endoplasmic reticulum (ER) Ca2+ sensor, STIM1, in response to store depletion triggered by stimulation of a variety of cell surface G-protein coupled and tyrosine kinase receptors. Work in the last decade has revealed that the Orai1 gating process is highly cooperative and strongly al...
Source: The Journal of Physiology - April 5, 2019 Category: Physiology Authors: Yeung PS, Yamashita M, Prakriya M Tags: J Physiol Source Type: research

Fructose and metabolic health: governed by hepatic glycogen status?
This article is protected by copyright. All rights reserved. PMID: 30950506 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 5, 2019 Category: Physiology Authors: Hengist A, Koumanov F, Gonzalez JT Tags: J Physiol Source Type: research

The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production.
Abstract KEY POINTS: Hypertrophic cardiomyopathy (HCM) is a genetic disease that causes thickening of the heart's ventricular walls and is a leading cause of sudden cardiac death. HCM is caused by missense mutations in muscle proteins including myosin, but how these mutations alter muscle mechanical performance in largely unknown. We investigated the disease mechanism for HCM myosin mutation R249Q by expressing it in the indirect flight muscle of Drosophila melanogaster and measuring alterations to muscle and flight performance. Muscle mechanical analysis revealed R249Q decreased muscle power production due to slowe...
Source: The Journal of Physiology - April 4, 2019 Category: Physiology Authors: Bell KM, Kronert WA, Huang A, Bernstein SI, Swank DM Tags: J Physiol Source Type: research

A preclinical model of non-invasive stimulation reduces spinal cord injury initiated spasticity.
PMID: 30945290 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 3, 2019 Category: Physiology Authors: Holland SD Tags: J Physiol Source Type: research

Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons.
PMID: 30938458 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 2, 2019 Category: Physiology Authors: Huckstepp RTR Tags: J Physiol Source Type: research

Diverse tuning underlies sparse activity in L2/3 vibrissal cortex of awake mice.
This article is protected by copyright. All rights reserved. PMID: 30932197 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 1, 2019 Category: Physiology Authors: Ranjbar-Slamloo Y, Arabzadeh E Tags: J Physiol Source Type: research

Successful climbing to extreme altitude is a hairy venture.
PMID: 30937911 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 1, 2019 Category: Physiology Authors: Kayser B Tags: J Physiol Source Type: research

Identifying what makes a neuron fire.
PMID: 30931533 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 31, 2019 Category: Physiology Authors: Diamond ME, Wyllie DJA Tags: J Physiol Source Type: research

Enhancing career development of postdoctoral trainees: act locally and beyond.
PMID: 30929265 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 31, 2019 Category: Physiology Authors: Omary MB, Shah YM, Schnell S, Subramanian S, Swanson MS, O'Riordan MX Tags: J Physiol Source Type: research

Drugging transcription in heart failure.
This article is protected by copyright. All rights reserved. PMID: 30927446 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 30, 2019 Category: Physiology Authors: Padmanabhan A, Haldar SM Tags: J Physiol Source Type: research

A voltage-dependent depolarization induced by low-external glucose in neurons of the nucleus of the tractus solitarius: interaction with KATP channels.
This article is protected by copyright. All rights reserved. PMID: 30927460 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 30, 2019 Category: Physiology Authors: De Bernardis Murat C, Leão RM Tags: J Physiol Source Type: research

Letter to the Editor.
PMID: 30924149 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 29, 2019 Category: Physiology Authors: Crocini C, Ferrantini C, Coppini R, Pavone FS, Poggesi C, Cerbai E, Sacconi L Tags: J Physiol Source Type: research

Embryogenesis of the peristaltic reflex: Insights into the myogenic to neurogenic transition of gut motility.
This article is protected by copyright. All rights reserved. PMID: 30924929 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 29, 2019 Category: Physiology Authors: Chevalier NR, Dacher N, Jacques C, Langlois L, Guedj C, Faklaris O Tags: J Physiol Source Type: research

Top-Down or Bottom Up: Decreased Stimulus Salience Increases Responses to Predictable Stimuli of Auditory Thalamic Neurons.
This article is protected by copyright. All rights reserved. PMID: 30924931 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 29, 2019 Category: Physiology Authors: Kommajosyula SP, Cai R, Bartlett E, Caspary DM Tags: J Physiol Source Type: research

Protein composition of the muscle mitochondrial reticulum during postnatal development.
In conclusion, mitochondrial networks transform from a fibre parallel to perpendicular orientation during the second and third weeks after birth in murine glycolytic skeletal muscle. This structural transition is accompanied by a change in protein expression profile from mitochondria designed for coordinated cellular assembly to mitochondria highly specialized for cellular energy metabolism. This article is protected by copyright. All rights reserved. PMID: 30919448 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: Kim Y, Yang DS, Katti P, Glancy B Tags: J Physiol Source Type: research

Disparity among muscles: Different levels of plasticity of cortical representation of different muscles revealed by transcranial magnetic stimulation.
PMID: 30919958 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: Lazzaro VD Tags: J Physiol Source Type: research

Motor unit properties of rapid force development during explosive contractions.
PMID: 30919962 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: Mota JA, Gerstner GR, Giuliani HK Tags: J Physiol Source Type: research

5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses through Src kinase in the dendrites of rat jaw-closing motoneurons.
This article is protected by copyright. All rights reserved. PMID: 30919966 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: Dantsuji M, Nakamura S, Nakayama K, Mochizuki A, Park SK, Bae YC, Ozeki M, Inoue T Tags: J Physiol Source Type: research

Parkin the progression of sarcopenia.
en JR PMID: 30919980 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: Henríquez-Olguin C, Knudsen JR Tags: J Physiol Source Type: research

Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons.
This article is protected by copyright. All rights reserved. PMID: 30920662 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: Sanz Diez A, Najac M, De Saint Jan D Tags: J Physiol Source Type: research

FGF21: an endocrine inhibitor of sugar and alcohol appetite.
This article is protected by copyright. All rights reserved. PMID: 30921473 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 28, 2019 Category: Physiology Authors: von Holstein-Rathlou S, Gillum MP Tags: J Physiol Source Type: research

Modular organization of the murine locomotor pattern in presence and absence of sensory feedback from muscle spindles.
This article is protected by copyright. All rights reserved. PMID: 30916787 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 27, 2019 Category: Physiology Authors: Santuz A, Akay T, Mayer WP, Wells TL, Schroll A, Arampatzis A Tags: J Physiol Source Type: research

Trefoil Factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids.
Conclusion Our work demonstrates that intracellular Ca2+ mobilization occurs within gastric epithelial cells adjacent to the damage site to promote repair by mechanisms that involve TFF2 signaling via CXCR4, and activation of EGFR and ERK1/2. Furthermore NHE2 is shown to be important for efficient repair, and to operate via a mechanism either downstream or independent of calcium mobilization. This article is protected by copyright. All rights reserved. PMID: 30912855 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 26, 2019 Category: Physiology Authors: Engevik KA, Hanyu H, Matthis AL, Zhang T, Frey MR, Oshima Y, Aihara E, Montrose MH Tags: J Physiol Source Type: research

Cerebellar rTMS restores pharyngeal brain activity and swallowing behaviour after disruption by a cortical virtual lesion.
Abstract BACKGROUND AND AIMS: Repetitive transcranial magnetic stimulation (rTMS) can alter neuronal activity within the brain with therapeutic potential. Low frequency stimulation to the 'dominant' cortical swallowing projection induces a 'virtual-lesion' transiently suppressing cortical excitability and disrupting swallowing behaviour. Here, we compared the ability of ipsi-lesional, contra-lesional and sham cerebellar rTMS to reverse the effects of a 'virtual-lesion' in health. METHODS: Two groups of healthy participants (n = 15/group) were intubated with pharyngeal catheters. Baseline pharyngeal ...
Source: The Journal of Physiology - March 25, 2019 Category: Physiology Authors: Sasegbon A, Watanabe M, Simons A, Michou E, Vasant DH, Magara J, Bath P, Rothwell J, Inoue M, Hamdy S Tags: J Physiol Source Type: research

How motor unit recruitment speed and discharge rates determine the rate of force development.
PMID: 30907430 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 25, 2019 Category: Physiology Authors: Wiegel P, Centner C, Kurz A Tags: J Physiol Source Type: research

Enhanced activity of multiple TRIC-B channels; an ER/SR mechanism to boost counterion currents.
This article is protected by copyright. All rights reserved. PMID: 30907436 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 25, 2019 Category: Physiology Authors: O'Brien F, Eberhardt D, Witschas K, El-Ajouz S, Iida T, Nishi M, Takeshima H, Sitsapesan R, Venturi E Tags: J Physiol Source Type: research

Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control.
This article is protected by copyright. All rights reserved. PMID: 30908629 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 25, 2019 Category: Physiology Authors: Ju C, Bosman LWJ, Hoogland TM, Velauthapillai A, Murugesan P, Warnaar P, van Genderen RM, Negrello M, De Zeeuw CI Tags: J Physiol Source Type: research

Reduced computational modeling of K ölliker-Fuse contributions to breathing patterns in Rett syndrome.
This article is protected by copyright. All rights reserved ABSTRACT: Rett syndrome (RTT) is a developmental disorder that can lead to respiratory disturbances featuring prolonged apneas of variable durations. Determining the mechanisms underlying these effects at the level of respiratory neural circuits would have significant implications for treatment efforts and would also enhance our understanding of respiratory rhythm generation and control. While experimental studies have suggested possible factors contributing to the respiratory patterns of RTT, we take a novel computational approach to the investigation of RTT, whi...
Source: The Journal of Physiology - March 25, 2019 Category: Physiology Authors: Wittman S, Abdala AP, Rubin JE Tags: J Physiol Source Type: research

Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa.
This article is protected by copyright. All rights reserved. PMID: 30893472 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 20, 2019 Category: Physiology Authors: Simpson LL, Busch SA, Oliver SJ, Ainslie PN, Stembridge M, Steinback CD, Moore JP Tags: J Physiol Source Type: research

Big heart, no longer a big problem: Using catecholamine-based quantifications may be an effective means to prescribe exercise to non-obstructive HCM patients.
PMID: 30891752 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 19, 2019 Category: Physiology Authors: Spector S, Debi R, Shin J Tags: J Physiol Source Type: research

From "De Motu Animalium" (1680) to "De Neuron Motorium Velocitate" (2019): towards a better understanding of how the nervous system drives muscles.
From "De Motu Animalium" (1680) to "De Neuron Motorium Velocitate" (2019): towards a better understanding of how the nervous system drives muscles. J Physiol. 2019 Mar 18;: Authors: Maffiuletti NA PMID: 30883737 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 18, 2019 Category: Physiology Authors: Maffiuletti NA Tags: J Physiol Source Type: research

Challenging metabolic tissues with fructose: Tissue-specific and sex-specific responses.
This article is protected by copyright. All rights reserved. PMID: 30883738 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 18, 2019 Category: Physiology Authors: Pinnick KE, Hodson L Tags: J Physiol Source Type: research

Maternal programming by hypoxia alters the molecular composition of the oviduct of her offspring, first pathway her grandchildren will transit: A potential novel pathway for intergenerational programming?
PMID: 30883756 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 18, 2019 Category: Physiology Authors: Nathanielsz PW Tags: J Physiol Source Type: research

Is the fountain of youth in the gut microbiome?
PMID: 30875099 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 15, 2019 Category: Physiology Authors: Cryan JF, Boehme M, Dinan TG Tags: J Physiol Source Type: research

The role of tonic glycinergic conductance in cerebellar granule cells signalling and the effect of gain-of-function mutation.
This article is protected by copyright. All rights reserved. PMID: 30875431 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 15, 2019 Category: Physiology Authors: McLaughlin C, Clements J, Oprişoreanu AM, Sylantyev S Tags: J Physiol Source Type: research

Cardiomyopathy in obesity, insulin resistance or diabetes.
This article is protected by copyright. All rights reserved. PMID: 30869158 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 14, 2019 Category: Physiology Authors: Nakamura M, Sadoshima J Tags: J Physiol Source Type: research

Chemosensitivity of Phox2b-expressing retrotrapezoid neurons is mediated in part by input from 5-HT neurons.
This article is protected by copyright. All rights reserved. PMID: 30866045 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 13, 2019 Category: Physiology Authors: Wu Y, Proch KL, Teran FA, Lechtenberg RJ, Kothari H, Richerson GB Tags: J Physiol Source Type: research

Channel surfing: new insights into plasticity of excitation-contraction coupling.
PMID: 30854650 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 10, 2019 Category: Physiology Authors: Louch WE Tags: J Physiol Source Type: research

Misleading with citation statistics?
PMID: 30854651 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 10, 2019 Category: Physiology Authors: Bennet L, Eisner DA, Gunn AJ Tags: J Physiol Source Type: research

Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: Role of the endothelin B receptor.
Abstract Endothelin-1 (ET-1) is an indicator of endothelial injury and dysfunction and is elevated in women with androgen excess polycystic ovary syndrome (AE-PCOS). The endothelin B receptor (ETB R) subtype mediates vasodilatation, but is blunted in women with PCOS. We hypothesized that androgen drives endothelial dysfunction in AE-PCOS women and estradiol (EE) administration reverses these effects. We assessed microvascular endothelial function in women with AE-PCOS (7 lean and 7 obese) and without AE-PCOS (Controls, 6 lean, 7 obese). Only obese AE-PCOS women were insulin resistant (IR). We evaluated cutaneous v...
Source: The Journal of Physiology - March 7, 2019 Category: Physiology Authors: Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS Tags: J Physiol Source Type: research