Does central chemoreceptor blood flow increase with CO < sub > 2 < /sub > tension?
J Physiol. 2024 May 7. doi: 10.1113/JP286058. Online ahead of print.NO ABSTRACTPMID:38713148 | DOI:10.1113/JP286058 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 7, 2024 Category: Physiology Authors: Nasimi A Guluzade Joshua D Huggard Source Type: research
Muscle contractile properties directly influence shared synaptic inputs to spinal motor neurons
This study investigated the impact of changing muscle length on the shared synaptic oscillations to spinal motor neurons, particularly in the physiological tremor band. Fourteen healthy individuals performed low-level dorsiflexion contractions at ankle joint angles of 90° and 130°, while high-density surface electromyography (HDsEMG) was recorded from the tibialis anterior (TA). We decomposed the HDsEMG into motor units spike trains and calculated the motor units' coherence within the delta (1-5 Hz), alpha (5-15 Hz), and beta (15-35 Hz) bands. Additionally, force steadiness and force spectral power within the tremor band...
Source: The Journal of Physiology - May 6, 2024 Category: Physiology Authors: H élio V Cabral J Greig Inglis Alessandro Cudicio Marta Cogliati Claudio Orizio Utku S Yavuz Francesco Negro Source Type: research
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials
J Physiol. 2024 May 5. doi: 10.1113/JP285459. Online ahead of print.ABSTRACTCa2+ signalling plays a crucial role in determining lymphatic muscle cell excitability and contractility through its interaction with the Ca2+-activated Cl- channel anoctamin 1 (ANO1). In contrast, the large-conductance (BK) Ca2+-activated K+ channel (KCa) and other KCa channels have prominent vasodilatory actions by hyperpolarizing vascular smooth muscle cells. Here, we assessed the expression and contribution of the KCa family to mouse and rat lymphatic collecting vessel contractile function. The BK channel was the only KCa channel consistently e...
Source: The Journal of Physiology - May 5, 2024 Category: Physiology Authors: Rebecca C Harlow Grace A Pea Sarah E Broyhill Advaya Patro Karen H Bromert Randolph H Stewart Cristine L Heaps Jorge A Castorena-Gonzalez Ranjeet M Dongaonkar Scott D Zawieja Source Type: research
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials
J Physiol. 2024 May 5. doi: 10.1113/JP285459. Online ahead of print.ABSTRACTCa2+ signalling plays a crucial role in determining lymphatic muscle cell excitability and contractility through its interaction with the Ca2+-activated Cl- channel anoctamin 1 (ANO1). In contrast, the large-conductance (BK) Ca2+-activated K+ channel (KCa) and other KCa channels have prominent vasodilatory actions by hyperpolarizing vascular smooth muscle cells. Here, we assessed the expression and contribution of the KCa family to mouse and rat lymphatic collecting vessel contractile function. The BK channel was the only KCa channel consistently e...
Source: The Journal of Physiology - May 5, 2024 Category: Physiology Authors: Rebecca C Harlow Grace A Pea Sarah E Broyhill Advaya Patro Karen H Bromert Randolph H Stewart Cristine L Heaps Jorge A Castorena-Gonzalez Ranjeet M Dongaonkar Scott D Zawieja Source Type: research
Is morning exercise really better for you?
J Physiol. 2024 May 4. doi: 10.1113/JP286776. Online ahead of print.NO ABSTRACTPMID:38703037 | DOI:10.1113/JP286776 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 4, 2024 Category: Physiology Authors: Andr é Pontes-Silva Andr é Luiz Lopes Source Type: research
Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia
In this study, we focused on OT and CRH individually and together on nTS activity from rats exposed to either CIH or normoxia control. We show that after CIH, CRH alone and with OT increased to a greater extent overall nTS discharge, neuronal calcium influx, synaptic transmission to second-order nTS neurons, and OT and CRH receptor expression. These results provide insights into the underlying circuits and mechanisms contributing to autonomic dysfunction during periods of episodic breathing.PMID:38698722 | DOI:10.1113/JP286069 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 3, 2024 Category: Physiology Authors: Procopio Gama de Barcellos Filho Heather A Dantzler Eileen M Hasser David D Kline Source Type: research
The phoenix's journey: unravelling muscle acidosis in the exercise pressor reflex
J Physiol. 2024 May 3. doi: 10.1113/JP286722. Online ahead of print.NO ABSTRACTPMID:38700438 | DOI:10.1113/JP286722 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 3, 2024 Category: Physiology Authors: Alec L E Butenas Source Type: research
Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia
In this study, we focused on OT and CRH individually and together on nTS activity from rats exposed to either CIH or normoxia control. We show that after CIH, CRH alone and with OT increased to a greater extent overall nTS discharge, neuronal calcium influx, synaptic transmission to second-order nTS neurons, and OT and CRH receptor expression. These results provide insights into the underlying circuits and mechanisms contributing to autonomic dysfunction during periods of episodic breathing.PMID:38698722 | DOI:10.1113/JP286069 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 3, 2024 Category: Physiology Authors: Procopio Gama de Barcellos Filho Heather A Dantzler Eileen M Hasser David D Kline Source Type: research
The phoenix's journey: unravelling muscle acidosis in the exercise pressor reflex
J Physiol. 2024 May 3. doi: 10.1113/JP286722. Online ahead of print.NO ABSTRACTPMID:38700438 | DOI:10.1113/JP286722 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 3, 2024 Category: Physiology Authors: Alec L E Butenas Source Type: research
Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia
In this study, we focused on OT and CRH individually and together on nTS activity from rats exposed to either CIH or normoxia control. We show that after CIH, CRH alone and with OT increased to a greater extent overall nTS discharge, neuronal calcium influx, synaptic transmission to second-order nTS neurons, and OT and CRH receptor expression. These results provide insights into the underlying circuits and mechanisms contributing to autonomic dysfunction during periods of episodic breathing.PMID:38698722 | DOI:10.1113/JP286069 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 3, 2024 Category: Physiology Authors: Procopio Gama de Barcellos Filho Heather A Dantzler Eileen M Hasser David D Kline Source Type: research
Genetic code expansion, an emerging tool in the Ca < sup > 2+ < /sup > ion channel field
J Physiol. 2024 May 2. doi: 10.1113/JP285840. Online ahead of print.ABSTRACTVarious methods for characterizing binding forces as well as for monitoring and remote control of ion channels are still emerging. A recent innovation is the direct incorporation of unnatural amino acids (UAAs) with corresponding biophysical or biochemical properties, which are integrated using genetic code expansion technology. Minimal changes to natural amino acids, which are achieved by chemical synthesis of corresponding UAAs, are valuable tools to provide insight into the contributions of physicochemical properties of side chains in binding ev...
Source: The Journal of Physiology - May 2, 2024 Category: Physiology Authors: Julia S öllner Isabella Derler Source Type: research
Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle
J Physiol. 2024 May 2. doi: 10.1113/JP286072. Online ahead of print.ABSTRACTThere is a growing appreciation that regulation of muscle contraction requires both thin filament and thick filament activation in order to fully activate the sarcomere. The prevailing mechano-sensing model for thick filament activation was derived from experiments on fast-twitch muscle. We address the question whether, or to what extent, this mechanism can be extrapolated to the slow muscle in the hearts of large mammals, including humans. We investigated the similarities and differences in structural signatures of thick filament activation in por...
Source: The Journal of Physiology - May 2, 2024 Category: Physiology Authors: Jing Zhao Lin Qi Shengyao Yuan Thomas C Irving Weikang Ma Source Type: research
A tribute to Dr Frederick Sachs
J Physiol. 2024 May 2. doi: 10.1113/JP286244. Online ahead of print.NO ABSTRACTPMID:38695842 | DOI:10.1113/JP286244 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 2, 2024 Category: Physiology Authors: Thomas Suchyna Source Type: research
Muscle matters: exploring the contributions of ageing skeletal muscle to metabolic syndrome
J Physiol. 2024 May 2. doi: 10.1113/JP286406. Online ahead of print.NO ABSTRACTPMID:38695856 | DOI:10.1113/JP286406 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 2, 2024 Category: Physiology Authors: Daniel L Scurto Vito A Pipitone Jacob M Ouellette Dylan J Hian-Cheong Fasih A Rahman Source Type: research
The ultimate trifecta of muscle: force, activation and length
J Physiol. 2024 May 2. doi: 10.1113/JP286596. Online ahead of print.NO ABSTRACTPMID:38696694 | DOI:10.1113/JP286596 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 2, 2024 Category: Physiology Authors: Kealey J Wohlgemuth Carina M Velasquez Kathryn E Southall McKenzie M Hare Source Type: research
