Role of tissue biomechanics in the formation and function of myocardial trabeculae in zebrafish embryos
J Physiol. 2024 Feb 12. doi: 10.1113/JP285490. Online ahead of print.ABSTRACTCardiac trabeculae are uneven ventricular muscular structures that develop during early embryonic heart development at the outer curvature of the ventricle. Their biomechanical function is not completely understood, and while their formation is known to be mechanosensitive, it is unclear whether ventricular tissue internal stresses play an important role in their formation. Here, we performed imaging and image-based cardiac biomechanics simulations on zebrafish embryonic ventricles to investigate these issues. Microscopy-based ventricular strain m...
Source: The Journal of Physiology - February 12, 2024 Category: Physiology Authors: Adriana Gaia Cairelli Alex Gendernalik Wei Xuan Chan Phuc Nguyen Julien Vermot Juhyun Lee David Bark Choon Hwai Yap Source Type: research
Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats
J Physiol. 2024 Feb 10. doi: 10.1113/JP286118. Online ahead of print.ABSTRACTWe determined the role played by the transient receptor potential canonical 6 (TRPC6) channel in evoking the mechanical component of the exercise pressor reflex in male decerebrated Sprague-Dawley rats. TRPC6 channels were identified by quadruple-labelled (DiI, TRPC6, neurofilament-200 and peripherin) immunohistochemistry in dorsal root ganglion (DRG) cells innervating the triceps surae muscles (n = 12). The exercise pressor reflex was evoked by statically contracting the triceps surae muscles before and after injection of the TRPC6 antagonist BI-...
Source: The Journal of Physiology - February 10, 2024 Category: Physiology Authors: Guillaume P Ducrocq Laura Anselmi Salvatore L Stella Steven W Copp Victor Ruiz-Velasco Marc P Kaufman Source Type: research
How neural networks walk and chew gum
J Physiol. 2024 Feb 10. doi: 10.1113/JP286287. Online ahead of print.NO ABSTRACTPMID:38340086 | DOI:10.1113/JP286287 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 10, 2024 Category: Physiology Authors: Nathan A Baertsch Ryan S Phillips Source Type: research
Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep
J Physiol. 2024 Feb 8. doi: 10.1113/JP285079. Online ahead of print.ABSTRACTSympathetic transduction is the study of how impulses of sympathetic nerve activity (SNA) affect end-organ function. Recently, the transduction of resting bursts of muscle SNA (MSNA) has been investigated and shown to have a role in the maintenance of blood pressure through changes in vascular tone in humans. In the present study, we investigate whether directly recorded resting cardiac SNA (CSNA) regulates heart rate (HR), coronary blood flow (CoBF), coronary vascular conductance (CVC), cardiac output (CO) and mean arterial pressure. Instrumentati...
Source: The Journal of Physiology - February 8, 2024 Category: Physiology Authors: Dilsha Gimhani Julia Shanks Mridula Pachen Joshua W-H Chang Rohit Ramchandra Source Type: research
Blockage of aquaporin-3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration
In conclusion, our data show that AQP3 peroxiporin activity is crucial for melanoma progression and highlight organogold compounds as promising AQP3 inhibitors with implications in melanoma cell adhesion, proliferation and migration, unveiling their potential as anticancer drugs against AQP3-overexpressing tumours. KEY POINTS: AQP3 affects cellular redox balance. Gold compounds inhibit AQP3 permeability in melanoma cells. AQP3 is involved in cell adhesion, proliferation and migration of melanoma. Blockage of AQP3 peroxiporin activity impairs melanoma cell migration. Gold compounds are potential anticancer drug leads for AQ...
Source: The Journal of Physiology - February 7, 2024 Category: Physiology Authors: In ês V da Silva Catarina Pimp ão In ês Paccetti-Alves Sophie R Thomas Andreia Barateiro Angela Casini Gra ça Soveral Source Type: research
What is the point of cerebral blood flow?
J Physiol. 2024 Feb 7. doi: 10.1113/JP286262. Online ahead of print.NO ABSTRACTPMID:38323981 | DOI:10.1113/JP286262 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 7, 2024 Category: Physiology Authors: Jay M J R Carr Source Type: research
Pre-intervention myocardial stress is a good predictor of aortic valvoluplasty outcome for fetal critical aortic stenosis and evolving HLHS
J Physiol. 2024 Feb 7. doi: 10.1113/JP285475. Online ahead of print.ABSTRACTFetal critical aortic stenosis with evolving hypoplastic left heart syndrome (CAS-eHLHS) causes biomechanical and functional aberrations, leading to a high risk of progression to hypoplastic left heart syndrome (HLHS) at birth. Fetal aortic valvuloplasty (FAV) can resolve outflow obstruction and may reduce progression risk. However, it is currently difficult to accurately predict which patients will respond to the intervention and become functionally biventricular (BV) at birth, as opposed to becoming functionally univentricular (UV). This predicti...
Source: The Journal of Physiology - February 7, 2024 Category: Physiology Authors: Laura Green Wei Xuan Chan Indumita Prakash Andreas Tulzer Gerald Tulzer Choon Hwai Yap Source Type: research
Integrate chaos theory with Epoker and leave God out of it!
J Physiol. 2024 Feb 7. doi: 10.1113/JP286233. Online ahead of print.NO ABSTRACTPMID:38324243 | DOI:10.1113/JP286233 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 7, 2024 Category: Physiology Authors: Robert Root-Bernstein Source Type: research
Does dopamine mediate the effects of exercise on cognition?
J Physiol. 2024 Feb 6. doi: 10.1113/JP286136. Online ahead of print.NO ABSTRACTPMID:38319872 | DOI:10.1113/JP286136 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 6, 2024 Category: Physiology Authors: Marc Roig Jacopo Cristini Source Type: research
The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation
J Physiol. 2024 Feb 6. doi: 10.1113/JP285697. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is a supraventricular tachyarrhythmia that is strongly associated with cardiovascular (CV) disease and sedentary lifestyles. Despite the benefits of exercise on overall health, AF incidence in high-level endurance athletes rivals that of CV disease patients, suggesting a J-shaped relationship with AF. To investigate the dependence of AF vulnerability on exercise, we varied daily swim durations (120, 180 or 240 min day-1 ) in 7-week-old male CD1 mice. We assessed mice after performing equivalent amounts of cumulative work du...
Source: The Journal of Physiology - February 6, 2024 Category: Physiology Authors: Ren ée A Gorman Simona Yakobov Nazari Polidovitch Ryan Debi Victoria C Sanfrancesco David A Hood Robert Lakin Peter H Backx Source Type: research
Cracking 'the Da Vinci code' of conduct hidden in Ca < sub > v < /sub > 2.1 α1 subunit for presynaptic occupation
J Physiol. 2024 Feb 6. doi: 10.1113/JP286116. Online ahead of print.NO ABSTRACTPMID:38319956 | DOI:10.1113/JP286116 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 6, 2024 Category: Physiology Authors: Adam Fekete Lu-Yang Wang Source Type: research
How much exercise is too much? Understanding the impact on atrial remodelling
J Physiol. 2024 Feb 6. doi: 10.1113/JP286222. Online ahead of print.NO ABSTRACTPMID:38319974 | DOI:10.1113/JP286222 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 6, 2024 Category: Physiology Authors: Xavier O Scott Na Li Source Type: research
Examining the implications of glutathione peroxidase 4 overexpression and its impact on sarcopenia phenotypes in mice
J Physiol. 2024 Feb 3. doi: 10.1113/JP285881. Online ahead of print.NO ABSTRACTPMID:38308858 | DOI:10.1113/JP285881 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 3, 2024 Category: Physiology Authors: Scylas Jos é de Andrade Junior Matheus Biscaro Rocha Carlos Kiyoshi Katashima Source Type: research
Reply from Daniel Phillips and Denis Noble
J Physiol. 2024 Feb 2. doi: 10.1113/JP286224. Online ahead of print.NO ABSTRACTPMID:38305416 | DOI:10.1113/JP286224 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 2, 2024 Category: Physiology Authors: Daniel Phillips Denis Noble Source Type: research
Acylation stimulating protein/C3adesArg in the metabolic states: role of adipocyte dysfunction in obesity complications
In conclusion, these findings validate that obesity is a low-grade inflammatory status with multiorgan involvement and sex differences, demonstrating dynamic interactions between immune and metabolic response determinants.PMID:38305477 | DOI:10.1113/JP285127 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 2, 2024 Category: Physiology Authors: Reza Rezvani Mohammad Reza Shadmand Foumani Moghadam Katherine Cianflone Source Type: research
