Death by hypoxia: what were they thinking?
J Physiol. 2024 Feb 24. doi: 10.1113/JP286347. Online ahead of print.NO ABSTRACTPMID:38401033 | DOI:10.1113/JP286347 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 24, 2024 Category: Physiology Authors: Vaughan G Macefield Source Type: research
Conserved mammalian muscle mechanics during eccentric contractions
J Physiol. 2024 Feb 24. doi: 10.1113/JP285549. Online ahead of print.ABSTRACTSkeletal muscle has a broad range of biomechanical functions, including power generation and energy absorption. These roles are underpinned by the force-velocity relationship, which comprises two distinct components: a concentric and an eccentric force-velocity relationship. The concentric component has been extensively studied across a wide range of muscles with different muscle properties. However, to date, little progress has been made in accurately characterising the eccentric force-velocity relationship in mammalian muscle with varying muscle...
Source: The Journal of Physiology - February 24, 2024 Category: Physiology Authors: Roger W P Kissane Graham N Askew Source Type: research
Death by hypoxia: what were they thinking?
J Physiol. 2024 Feb 24. doi: 10.1113/JP286347. Online ahead of print.NO ABSTRACTPMID:38401033 | DOI:10.1113/JP286347 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 24, 2024 Category: Physiology Authors: Vaughan G Macefield Source Type: research
Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO < sub > 3 < /sub > < sup > - < /sup > secretion
J Physiol. 2024 Feb 22. doi: 10.1113/JP285702. Online ahead of print.ABSTRACTType 1 diabetes is a disease of the endocrine pancreas; however, it also affects exocrine function. Although most studies have examined the effects of diabetes on acinar cells, much less is known regarding ductal cells, despite their important protective function in the pancreas. Therefore, we investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice following an i.p. administration of streptozotocin. Pancreatic ductal fluid and HCO3 - secr...
Source: The Journal of Physiology - February 23, 2024 Category: Physiology Authors: Attila Ébert Eleon óra Gál Emese T óth Titanilla Sz ögi P éter Hegyi Vikt ória Venglovecz Source Type: research
Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO < sub > 3 < /sub > < sup > - < /sup > secretion
J Physiol. 2024 Feb 22. doi: 10.1113/JP285702. Online ahead of print.ABSTRACTType 1 diabetes is a disease of the endocrine pancreas; however, it also affects exocrine function. Although most studies have examined the effects of diabetes on acinar cells, much less is known regarding ductal cells, despite their important protective function in the pancreas. Therefore, we investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice following an i.p. administration of streptozotocin. Pancreatic ductal fluid and HCO3 - secr...
Source: The Journal of Physiology - February 23, 2024 Category: Physiology Authors: Attila Ébert Eleon óra Gál Emese T óth Titanilla Sz ögi P éter Hegyi Vikt ória Venglovecz Source Type: research
Making PEACE and LOVE in hypoxia: an emerging therapy for accelerated muscle injury regeneration?
J Physiol. 2024 Feb 20. doi: 10.1113/JP286241. Online ahead of print.NO ABSTRACTPMID:38379389 | DOI:10.1113/JP286241 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Tim Kambi č Johannes Burtscher Source Type: research
Residual force depression is not related to positive muscle fascicle work during submaximal voluntary dorsiflexion contractions in humans
J Physiol. 2024 Feb 21. doi: 10.1113/JP285703. Online ahead of print.ABSTRACTResidual force depression (rFD) following active muscle shortening is assumed to correlate most strongly with muscle work, but this has not been tested during voluntary contractions in humans. Using dynamometry, we compared steady-state ankle joint torques (N = 16) following tibialis anterior (TA) muscle-tendon unit (MTU) lengthening and shortening to the time-matched torque during submaximal voluntary fixed-end dorsiflexion reference contractions (REF) at a matched MTU length and EMG amplitude. Ultrasound revealed significantly reduced (P < 0....
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Brent James Raiteri Leon Lauret Daniel Hahn Source Type: research
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise
This study aimed to elucidate the role of the orexinergic nervous system in transmitting volitional motor signals, i.e. central command, to drive somatomotor and sympathetic cardiovascular responses. We first found that this system is activated by voluntary locomotor exercise as evidenced by an increased expression of Fos, a marker of neural activation, in the orexinergic neurons of Sprague-Dawley rats engaged in spontaneous wheel running. Next, using transgenic Orexin-Cre rats for optogenetic manipulation of orexinergic neurons, we found that optogenetic excitation of orexinergic neurons caused sympathoexcitation on a sub...
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Emi Narai Yuki Yoshimura Takaho Honaga Hiroyuki Mizoguchi Akihiro Yamanaka Takeshi Y Hiyama Tatsuo Watanabe Satoshi Koba Source Type: research
Neuropilin-1 regulates renin synthesis in juxtaglomerular cells
J Physiol. 2024 Feb 21. doi: 10.1113/JP285422. Online ahead of print.ABSTRACTRenin is the key enzyme of the systemic renin-angiotensin-aldosterone system, which plays an essential role in regulating blood pressure and maintaining electrolyte and extracellular volume homeostasis. Renin is mainly produced and secreted by specialized juxtaglomerular (JG) cells in the kidney. In the present study, we report for the first time that the conserved transmembrane receptor neuropilin-1 (NRP1) participates in the development of JG cells and plays a key role in renin production. We used the myelin protein zero-Cre (P0-Cre) to abrogate...
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Yunzhu Shen Kenza Lotenberg Jeremy Zaworski Katharina A-E Broeker Florence Vasseur Liliane Louedec Sandrine Placier Perrine Fr ère Marie-Christine Verpont Pierre Galichon David Buob Juliette Hadchouel Fabiola Terzi Christos Chatziantoniou Am élie Calmon Source Type: research
In vivo mitochondria-targeted protection against uterine artery vascular dysfunction and remodelling in rodent hypoxic pregnancy
J Physiol. 2024 Feb 21. doi: 10.1113/JP286178. Online ahead of print.ABSTRACTGestational hypoxia adversely affects uterine artery function, increasing complications. However, an effective therapy remains unidentified. Here, we show in rodent uterine arteries that hypoxic pregnancy promotes hypertrophic remodelling, increases constrictor reactivity via protein kinase C signalling, and triggers compensatory dilatation via nitric oxide-dependent mechanisms and stimulation of large conductance Ca2+ -activated K+ -channels. Maternal in vivo oral treatment with the mitochondria-targeted antioxidant MitoQ in hypoxic pregnancy nor...
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Zhongchao Wang Emily J Camm Anna Maria Nuzzo Ana-Mishel Spiroski Katie L Skeffington Thomas J Ashmore Alessandro Rolfo Tullia Todros Angela Logan Jin Ma Michael P Murphy Youguo Niu Dino A Giussani Source Type: research
Making PEACE and LOVE in hypoxia: an emerging therapy for accelerated muscle injury regeneration?
J Physiol. 2024 Feb 20. doi: 10.1113/JP286241. Online ahead of print.NO ABSTRACTPMID:38379389 | DOI:10.1113/JP286241 (Source: The Journal of Physiology)
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Tim Kambi č Johannes Burtscher Source Type: research
Residual force depression is not related to positive muscle fascicle work during submaximal voluntary dorsiflexion contractions in humans
J Physiol. 2024 Feb 21. doi: 10.1113/JP285703. Online ahead of print.ABSTRACTResidual force depression (rFD) following active muscle shortening is assumed to correlate most strongly with muscle work, but this has not been tested during voluntary contractions in humans. Using dynamometry, we compared steady-state ankle joint torques (N = 16) following tibialis anterior (TA) muscle-tendon unit (MTU) lengthening and shortening to the time-matched torque during submaximal voluntary fixed-end dorsiflexion reference contractions (REF) at a matched MTU length and EMG amplitude. Ultrasound revealed significantly reduced (P < 0....
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Brent James Raiteri Leon Lauret Daniel Hahn Source Type: research
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise
This study aimed to elucidate the role of the orexinergic nervous system in transmitting volitional motor signals, i.e. central command, to drive somatomotor and sympathetic cardiovascular responses. We first found that this system is activated by voluntary locomotor exercise as evidenced by an increased expression of Fos, a marker of neural activation, in the orexinergic neurons of Sprague-Dawley rats engaged in spontaneous wheel running. Next, using transgenic Orexin-Cre rats for optogenetic manipulation of orexinergic neurons, we found that optogenetic excitation of orexinergic neurons caused sympathoexcitation on a sub...
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Emi Narai Yuki Yoshimura Takaho Honaga Hiroyuki Mizoguchi Akihiro Yamanaka Takeshi Y Hiyama Tatsuo Watanabe Satoshi Koba Source Type: research
Neuropilin-1 regulates renin synthesis in juxtaglomerular cells
J Physiol. 2024 Feb 21. doi: 10.1113/JP285422. Online ahead of print.ABSTRACTRenin is the key enzyme of the systemic renin-angiotensin-aldosterone system, which plays an essential role in regulating blood pressure and maintaining electrolyte and extracellular volume homeostasis. Renin is mainly produced and secreted by specialized juxtaglomerular (JG) cells in the kidney. In the present study, we report for the first time that the conserved transmembrane receptor neuropilin-1 (NRP1) participates in the development of JG cells and plays a key role in renin production. We used the myelin protein zero-Cre (P0-Cre) to abrogate...
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Yunzhu Shen Kenza Lotenberg Jeremy Zaworski Katharina A-E Broeker Florence Vasseur Liliane Louedec Sandrine Placier Perrine Fr ère Marie-Christine Verpont Pierre Galichon David Buob Juliette Hadchouel Fabiola Terzi Christos Chatziantoniou Am élie Calmon Source Type: research
In vivo mitochondria-targeted protection against uterine artery vascular dysfunction and remodelling in rodent hypoxic pregnancy
J Physiol. 2024 Feb 21. doi: 10.1113/JP286178. Online ahead of print.ABSTRACTGestational hypoxia adversely affects uterine artery function, increasing complications. However, an effective therapy remains unidentified. Here, we show in rodent uterine arteries that hypoxic pregnancy promotes hypertrophic remodelling, increases constrictor reactivity via protein kinase C signalling, and triggers compensatory dilatation via nitric oxide-dependent mechanisms and stimulation of large conductance Ca2+ -activated K+ -channels. Maternal in vivo oral treatment with the mitochondria-targeted antioxidant MitoQ in hypoxic pregnancy nor...
Source: The Journal of Physiology - February 21, 2024 Category: Physiology Authors: Zhongchao Wang Emily J Camm Anna Maria Nuzzo Ana-Mishel Spiroski Katie L Skeffington Thomas J Ashmore Alessandro Rolfo Tullia Todros Angela Logan Jin Ma Michael P Murphy Youguo Niu Dino A Giussani Source Type: research
