Comment on: 'Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart' by Saint-Martin Willer et al
J Physiol. 2024 Apr 12. doi: 10.1113/JP286611. Online ahead of print.NO ABSTRACTPMID:38607230 | DOI:10.1113/JP286611 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Merten Pr üser Felix Wiedmann Constanze Schmidt Source Type: research
The nine lives of cat reflexes
J Physiol. 2024 Apr 11. doi: 10.1113/JP286594. Online ahead of print.NO ABSTRACTPMID:38602708 | DOI:10.1113/JP286594 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: J Duysens Source Type: research
Right place at the right time: Mitochondrial shape, distribution and inter-organelle interaction during skeletal muscle postnatal development
J Physiol. 2024 Apr 11. doi: 10.1113/JP286517. Online ahead of print.NO ABSTRACTPMID:38602797 | DOI:10.1113/JP286517 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: Itamar C G Jesus Marcos Eliezeck D ébora L Scheffer Source Type: research
How long is too long? No added benefit with prolonged ventilation with intact cord in preterm infants
J Physiol. 2024 Apr 11. doi: 10.1113/JP286492. Online ahead of print.NO ABSTRACTPMID:38602842 | DOI:10.1113/JP286492 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: Anup Katheria Satyan Lakshminrusimha Source Type: research
A skeptical look about the existence of the veno-arteriolar reflex
J Physiol. 2024 Apr 11. doi: 10.1113/JP286490. Online ahead of print.NO ABSTRACTPMID:38602858 | DOI:10.1113/JP286490 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: Gerardo Tusman Fernando Suarez Sipmann Stephan H B öhm Source Type: research
The nine lives of cat reflexes
J Physiol. 2024 Apr 11. doi: 10.1113/JP286594. Online ahead of print.NO ABSTRACTPMID:38602708 | DOI:10.1113/JP286594 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: J Duysens Source Type: research
Right place at the right time: Mitochondrial shape, distribution and inter-organelle interaction during skeletal muscle postnatal development
J Physiol. 2024 Apr 11. doi: 10.1113/JP286517. Online ahead of print.NO ABSTRACTPMID:38602797 | DOI:10.1113/JP286517 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: Itamar C G Jesus Marcos Eliezeck D ébora L Scheffer Source Type: research
How long is too long? No added benefit with prolonged ventilation with intact cord in preterm infants
J Physiol. 2024 Apr 11. doi: 10.1113/JP286492. Online ahead of print.NO ABSTRACTPMID:38602842 | DOI:10.1113/JP286492 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: Anup Katheria Satyan Lakshminrusimha Source Type: research
A skeptical look about the existence of the veno-arteriolar reflex
J Physiol. 2024 Apr 11. doi: 10.1113/JP286490. Online ahead of print.NO ABSTRACTPMID:38602858 | DOI:10.1113/JP286490 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 11, 2024 Category: Physiology Authors: Gerardo Tusman Fernando Suarez Sipmann Stephan H B öhm Source Type: research
Estimation of persistent sodium-current density in rat hippocampal mossy fibre boutons: Correction of space-clamp errors
J Physiol. 2024 Apr 9. doi: 10.1113/JP284657. Online ahead of print.ABSTRACTWe used whole-cell patch clamp to estimate the stationary voltage dependence of persistent sodium-current density (iNaP) in rat hippocampal mossy fibre boutons. Cox's method for correcting space-clamp errors was extended to the case of an isopotential compartment with attached neurites. The method was applied to voltage-ramp experiments, in which iNaP is assumed to gate instantaneously. The raw estimates of iNaP led to predicted clamp currents that were at variance with observation, hence an algorithm was devised to improve these estimates. Optiona...
Source: The Journal of Physiology - April 10, 2024 Category: Physiology Authors: Ricardo Murphy Henrik Alle J örg R P Geiger Johan F Storm Source Type: research
In Memoriam: Richard Miles: Neuroscience network has lost a key synapse
J Physiol. 2024 Apr 10. doi: 10.1113/JP286319. Online ahead of print.NO ABSTRACTPMID:38598307 | DOI:10.1113/JP286319 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 10, 2024 Category: Physiology Authors: Gy örgy Buzsáki Tam ás Freund Desdemona Fricker Attila I Guly ás Gilles Huberfeld Liset Menendez de la Prida Jean Christophe Poncer Katalin T óth Roger Traub Lucia Wittner Robert K S Wong Source Type: research
Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins
J Physiol. 2024 Apr 10. doi: 10.1113/JP283829. Online ahead of print.ABSTRACTTwo-pore channels and TRP mucolipins are ubiquitous endo-lysosomal cation channels of pathophysiological relevance. Both are Ca2+-permeable and regulated by phosphoinositides, principally PI(3,5)P2. Accumulating evidence has uncovered synergistic channel activation by PI(3,5)P2 and endogenous metabolites such as the Ca2+ mobilizing messenger NAADP, synthetic agonists including approved drugs and physical cues such as voltage and osmotic pressure. Here, we provide an overview of this coordination.PMID:38598430 | DOI:10.1113/JP283829 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 10, 2024 Category: Physiology Authors: Yu Yuan Dawid Ja ślan Taufiq Rahman Franz Bracher Christian Grimm Sandip Patel Source Type: research
Estimation of persistent sodium-current density in rat hippocampal mossy fibre boutons: Correction of space-clamp errors
J Physiol. 2024 Apr 9. doi: 10.1113/JP284657. Online ahead of print.ABSTRACTWe used whole-cell patch clamp to estimate the stationary voltage dependence of persistent sodium-current density (iNaP) in rat hippocampal mossy fibre boutons. Cox's method for correcting space-clamp errors was extended to the case of an isopotential compartment with attached neurites. The method was applied to voltage-ramp experiments, in which iNaP is assumed to gate instantaneously. The raw estimates of iNaP led to predicted clamp currents that were at variance with observation, hence an algorithm was devised to improve these estimates. Optiona...
Source: The Journal of Physiology - April 10, 2024 Category: Physiology Authors: Ricardo Murphy Henrik Alle J örg R P Geiger Johan F Storm Source Type: research
Changes in intra- and interlimb reflexes from hindlimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats
J Physiol. 2024 Apr 9. doi: 10.1113/JP286151. Online ahead of print.ABSTRACTWhen the foot dorsum contacts an obstacle during locomotion, cutaneous afferents signal central circuits to coordinate muscle activity in the four limbs. Spinal cord injury disrupts these interactions, impairing balance and interlimb coordination. We evoked cutaneous reflexes by electrically stimulating left and right superficial peroneal nerves before and after two thoracic lateral hemisections placed on opposite sides of the cord at 9- to 13-week interval in seven adult cats (4 males and 3 females). We recorded reflex responses in ten hindlimb an...
Source: The Journal of Physiology - April 9, 2024 Category: Physiology Authors: Stephen Mari Charly G Lecomte Ang èle N Merlet Johannie Audet Sirine Yassine Oussama Eddaoui Gabriel Genois Charl ène Nadeau Jonathan Harnie Ilya A Rybak Boris I Prilutsky Alain Frigon Source Type: research
Histone-deacetylation inhibitors - old tools in new applications may ameliorate the consequences of social isolation on mental health
J Physiol. 2024 Apr 9. doi: 10.1113/JP286505. Online ahead of print.NO ABSTRACTPMID:38593242 | DOI:10.1113/JP286505 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 9, 2024 Category: Physiology Authors: Lars Paeger Source Type: research
