Good night's sleep, good arterial health: are there differences between men and women living with obstructive sleep apnoea?
J Physiol. 2024 Mar 29. doi: 10.1113/JP286370. Online ahead of print.NO ABSTRACTPMID:38551969 | DOI:10.1113/JP286370 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 29, 2024 Category: Physiology Authors: Pedro Gabriel Senger Braga Sara Quaglia de Campos Giamp á Source Type: research
Good night's sleep, good arterial health: are there differences between men and women living with obstructive sleep apnoea?
J Physiol. 2024 Mar 29. doi: 10.1113/JP286370. Online ahead of print.NO ABSTRACTPMID:38551969 | DOI:10.1113/JP286370 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 29, 2024 Category: Physiology Authors: Pedro Gabriel Senger Braga Sara Quaglia de Campos Giamp á Source Type: research
Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration
This study sheds light on the regulatory function of FCGR2A in macrophage polarization, offering novel insights for IDD intervention strategies. KEY POINTS: This study unveils the role of FCGR2A in intervertebral disc (IVD) degeneration (IDD). FCGR2A knockdown mitigates IDD in cellular and animal models. Single-cell RNA-sequencing uncovers diverse macrophage subpopulations in degenerated IVDs. This study reveals the molecular mechanism of FCGR2A in regulating macrophage polarization. This study confirms the role of the NF-κB/STAT3 pathway in regulating macrophage polarization in IDD.PMID:38544414 | DOI:10.1113/JP285871 (S...
Source: The Journal of Physiology - March 28, 2024 Category: Physiology Authors: Jiaying Luo Guoxin Jin Shaoqian Cui Huan Wang Qi Liu Source Type: research
Role of arm reaching movement kinematics in friction perception at initial contact with smooth surfaces
J Physiol. 2024 Mar 28. doi: 10.1113/JP286027. Online ahead of print.ABSTRACTWhen manipulating objects, humans begin adjusting their grip force to friction within 100 ms of contact. During motor adaptation, subjects become aware of the slipperiness of touched surfaces. Previously, we have demonstrated that humans cannot perceive frictional differences when surfaces are brought in contact with an immobilised finger, but can do so when there is submillimeter lateral displacement or subjects actively make the contact movement. Similarly, in, we investigated how humans perceive friction in the absence of intentional explorator...
Source: The Journal of Physiology - March 28, 2024 Category: Physiology Authors: Naqash Afzal Sophie du Bois de Dunilac Alastair J Loutit Helen O Shea Pablo Martinez Ulloa Heba Khamis Richard M Vickery Micha ël Wiertlewski Stephen J Redmond Ingvars Birznieks Source Type: research
Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration
This study sheds light on the regulatory function of FCGR2A in macrophage polarization, offering novel insights for IDD intervention strategies. KEY POINTS: This study unveils the role of FCGR2A in intervertebral disc (IVD) degeneration (IDD). FCGR2A knockdown mitigates IDD in cellular and animal models. Single-cell RNA-sequencing uncovers diverse macrophage subpopulations in degenerated IVDs. This study reveals the molecular mechanism of FCGR2A in regulating macrophage polarization. This study confirms the role of the NF-κB/STAT3 pathway in regulating macrophage polarization in IDD.PMID:38544414 | DOI:10.1113/JP285871 (S...
Source: The Journal of Physiology - March 28, 2024 Category: Physiology Authors: Jiaying Luo Guoxin Jin Shaoqian Cui Huan Wang Qi Liu Source Type: research
Role of arm reaching movement kinematics in friction perception at initial contact with smooth surfaces
J Physiol. 2024 Mar 28. doi: 10.1113/JP286027. Online ahead of print.ABSTRACTWhen manipulating objects, humans begin adjusting their grip force to friction within 100 ms of contact. During motor adaptation, subjects become aware of the slipperiness of touched surfaces. Previously, we have demonstrated that humans cannot perceive frictional differences when surfaces are brought in contact with an immobilised finger, but can do so when there is submillimeter lateral displacement or subjects actively make the contact movement. Similarly, in, we investigated how humans perceive friction in the absence of intentional explorator...
Source: The Journal of Physiology - March 28, 2024 Category: Physiology Authors: Naqash Afzal Sophie du Bois de Dunilac Alastair J Loutit Helen O Shea Pablo Martinez Ulloa Heba Khamis Richard M Vickery Micha ël Wiertlewski Stephen J Redmond Ingvars Birznieks Source Type: research
Extended period of ventilation before delayed cord clamping augments left-to-right shunting and decreases systemic perfusion at birth in preterm lambs
J Physiol. 2024 Mar 26. doi: 10.1113/JP285799. Online ahead of print.ABSTRACTPrevious studies have suggested that an extended period of ventilation before delayed cord clamping (DCC) augments birth-related rises in pulmonary arterial (PA) blood flow. However, it is unknown whether this greater rise in PA flow is accompanied by increases in left ventricular (LV) output and systemic arterial perfusion or whether it reflects enhanced left-to-right shunting across the ductus arteriosus and/or foramen ovale (FO), with decreased systemic arterial perfusion. Using an established preterm lamb birth transition model, this study com...
Source: The Journal of Physiology - March 27, 2024 Category: Physiology Authors: Joseph J Smolich Kelly R Kenna Jonathan P Mynard Source Type: research
Mechanisms underpinning sympathoexcitation in hypoxia
J Physiol. 2024 Mar 27. doi: 10.1113/JP284579. Online ahead of print.ABSTRACTSympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as persisting in acclimatised lowland populations and with generational exposure in highland native populations of the Andean and Tibetan plateaus. The mechanisms mediating altitude sympathoexcitation are multifactorial, involving alterations in both peripheral autonomic reflexes and central neural pathways, and are dependent on the duration of exposure. Initially, hypoxia-induced sympathoexcitation appears to be an adaptive response, primarily mediated by regulatory ...
Source: The Journal of Physiology - March 27, 2024 Category: Physiology Authors: Lydia L Simpson Mike Stembridge Christoph Siebenmann Jonathan P Moore Justin S Lawley Source Type: research
A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders
J Physiol. 2024 Mar 27. doi: 10.1113/JP285427. Online ahead of print.ABSTRACTPeriodic breathing during sleep at high altitude is almost universal among sojourners. Here, in the context of acclimatization and adaptation, we provide a contemporary review on periodic breathing at high altitude, and explore whether this is an adaptive or maladaptive process. The mechanism(s), prevalence and role of periodic breathing in acclimatized lowlanders at high altitude are contrasted with the available data from adapted indigenous populations (e.g. Andean and Tibetan highlanders). It is concluded that (1) periodic breathing persists wi...
Source: The Journal of Physiology - March 27, 2024 Category: Physiology Authors: Alexander Patrician James D Anholm Philip N Ainslie Source Type: research
Reconsidering coronary circulation in the era of LV unloading - the underlying physiology in the non-physiological setting
J Physiol. 2024 Mar 27. doi: 10.1113/JP286424. Online ahead of print.NO ABSTRACTPMID:38535892 | DOI:10.1113/JP286424 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 27, 2024 Category: Physiology Authors: Masafumi Fukumitsu Keita Saku Source Type: research
Extended period of ventilation before delayed cord clamping augments left-to-right shunting and decreases systemic perfusion at birth in preterm lambs
J Physiol. 2024 Mar 26. doi: 10.1113/JP285799. Online ahead of print.ABSTRACTPrevious studies have suggested that an extended period of ventilation before delayed cord clamping (DCC) augments birth-related rises in pulmonary arterial (PA) blood flow. However, it is unknown whether this greater rise in PA flow is accompanied by increases in left ventricular (LV) output and systemic arterial perfusion or whether it reflects enhanced left-to-right shunting across the ductus arteriosus and/or foramen ovale (FO), with decreased systemic arterial perfusion. Using an established preterm lamb birth transition model, this study com...
Source: The Journal of Physiology - March 27, 2024 Category: Physiology Authors: Joseph J Smolich Kelly R Kenna Jonathan P Mynard Source Type: research
Mechanisms underpinning sympathoexcitation in hypoxia
J Physiol. 2024 Mar 27. doi: 10.1113/JP284579. Online ahead of print.ABSTRACTSympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as persisting in acclimatised lowland populations and with generational exposure in highland native populations of the Andean and Tibetan plateaus. The mechanisms mediating altitude sympathoexcitation are multifactorial, involving alterations in both peripheral autonomic reflexes and central neural pathways, and are dependent on the duration of exposure. Initially, hypoxia-induced sympathoexcitation appears to be an adaptive response, primarily mediated by regulatory ...
Source: The Journal of Physiology - March 27, 2024 Category: Physiology Authors: Lydia L Simpson Mike Stembridge Christoph Siebenmann Jonathan P Moore Justin S Lawley Source Type: research
A short treatment with resveratrol after a renal ischaemia-reperfusion injury prevents maladaptive repair and long-term chronic kidney disease in rats
This study assessed whether transient administration of RSV following ischaemia-reperfusion injury (IRI) could prevent the progression to CKD. Forty-one male Wistar rats were assigned randomly to sham surgery, bilateral renal ischaemia for 30 min (IR) or IR+RSV. The RSV treatment commenced 24 h after IRI and continued for 10 days. The rats were studied for either 10 days or 5 months, after which kidney function and structure were evaluated. Mitochondrial homeostasis, oxidant defence and renal inflammation state were also evaluated. Despite having the same severity of AKI, rats receiving RSV for 10 days after IRI exhibited ...
Source: The Journal of Physiology - March 26, 2024 Category: Physiology Authors: Miguel Ángel Martínez-Rojas Hiram Balc ázar Mar ía Susana Ponce-Nava Isaac Gonz ález-Soria Brenda Marquina-Castillo Rosalba P érez-Villalva Norma A Bobadilla Source Type: research
Functions require junctions: endurance exercise protects from age-induced alterations of the neuromuscular system
J Physiol. 2024 Mar 26. doi: 10.1113/JP286232. Online ahead of print.NO ABSTRACTPMID:38530283 | DOI:10.1113/JP286232 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 26, 2024 Category: Physiology Authors: Leonardo Matta Lukas Blaas Christoph Gibis Joel Guerra Source Type: research
Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial
In this study, nine males and nine females with type 2 diabetes undergoing metformin monotherapy (age 61 ± 8.2 years, mean ± SD) completed a 16-week crossover trial including 2-week baseline recording, 6 weeks randomly assigned to a morning exercise (07.00-10.00 h) or evening exercise (16.00-19.00 h) and a 2-week wash-out period. Exercise arms consisted of 30 min of walking at 70% of estimated max heart rate every other day. Glucose levels were measured with continuous glucose monitors and activity measured by wrist-worn monitors. Food-intake was recorded by 4-day food diaries during baseline, first and last 2 weeks of e...
Source: The Journal of Physiology - March 24, 2024 Category: Physiology Authors: Brenda J Pe ña Carrillo Emily Cope Sati Gurel Andres Traslosheros Amber Kenny Oscar Michot-Duval Nimesh Mody Mirela Delibegovic Sam Philip Frank Thies Dimitra Blana Brendan M Gabriel Source Type: research
