Ocular surface information seen from the somatosensory thalamus and cortex
J Physiol. 2024 Mar 8. doi: 10.1113/JP285008. Online ahead of print.ABSTRACTOcular Surface (OS) somatosensory innervation detects external stimuli producing perceptions, such as pain or dryness, the most relevant symptoms in many OS pathologies. Nevertheless, little is known about the central nervous system circuits involved in these perceptions, and how they integrate multimodal inputs in general. Here, we aim to describe the thalamic and cortical activity in response to OS stimulation of different modalities. Electrophysiological extracellular recordings in anaesthetized rats were used to record neural activity, while sa...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Enrique Velasco Marta Zaforas M Carmen Acosta Juana Gallar Juan Aguilar Source Type: research
PIEZO ion channels: force sensors of the interoceptive nervous system
J Physiol. 2024 Mar 8. doi: 10.1113/JP284077. Online ahead of print.ABSTRACTMany organs are designed to move: the heart pumps each second, the gastrointestinal tract squeezes and churns to digest food, and we contract and relax skeletal muscles to move our bodies. Sensory neurons of the peripheral nervous system detect signals from bodily tissues, including the forces generated by these movements, to control physiology. The processing of these internal signals is called interoception, but this is a broad term that includes a wide variety of both chemical and mechanical sensory processes. Mechanical senses are understudied,...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Yasmeen M F Hamed Britya Ghosh Kara L Marshall Source Type: research
Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support
In conclusion, mechanical LV support increases infarct coronary flow by extending diastole and augmenting coronary driving pressure. These changes were mainly driven by reduced LV diastolic pressure, indicating that the key regulator of coronary flow under mechanical LV support is downstream of the coronary artery, rather than upstream. Our study highlights the importance of LV diastolic pressure in infarct coronary flow regulation. KEY POINTS: Restoring ischaemic myocardial tissue perfusion is crucial for minimizing infarct size. Although mechanical left ventricular (LV) support has been suggested to improve infarct coron...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Tomoki Sakata Spyros A Mavropoulos Renata Mazurek Francisco J Romeo Anjali J Ravichandran Jonas M Marx Taro Kariya Kiyotake Ishikawa Source Type: research
Ocular surface information seen from the somatosensory thalamus and cortex
J Physiol. 2024 Mar 8. doi: 10.1113/JP285008. Online ahead of print.ABSTRACTOcular Surface (OS) somatosensory innervation detects external stimuli producing perceptions, such as pain or dryness, the most relevant symptoms in many OS pathologies. Nevertheless, little is known about the central nervous system circuits involved in these perceptions, and how they integrate multimodal inputs in general. Here, we aim to describe the thalamic and cortical activity in response to OS stimulation of different modalities. Electrophysiological extracellular recordings in anaesthetized rats were used to record neural activity, while sa...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Enrique Velasco Marta Zaforas M Carmen Acosta Juana Gallar Juan Aguilar Source Type: research
Mitochondrial calcium: An essential element for skeletal muscle performance and function
J Physiol. 2024 Mar 4. doi: 10.1113/JP286218. Online ahead of print.NO ABSTRACTPMID:38439553 | DOI:10.1113/JP286218 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Jaydeep Sharma Somnath Mondal Mahima Kumari Source Type: research
Postsynaptic β1 spectrin maintains Na < sup > + < /sup > channels at the neuromuscular junction
J Physiol. 2024 Mar 5. doi: 10.1113/JP285894. Online ahead of print.ABSTRACTSpectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 spectrin) were reported to cause both neuropathy and myopathy. Although the role of β4 spectrin in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown. Here, using a muscle specific...
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Ozlem Sert Xiaoyun Ding Chuansheng Zhang Ruifa Mi Ahmet Hoke Matthew N Rasband Source Type: research
Mitochondrial calcium: An essential element for skeletal muscle performance and function
J Physiol. 2024 Mar 4. doi: 10.1113/JP286218. Online ahead of print.NO ABSTRACTPMID:38439553 | DOI:10.1113/JP286218 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Jaydeep Sharma Somnath Mondal Mahima Kumari Source Type: research
Postsynaptic β1 spectrin maintains Na < sup > + < /sup > channels at the neuromuscular junction
J Physiol. 2024 Mar 5. doi: 10.1113/JP285894. Online ahead of print.ABSTRACTSpectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 spectrin) were reported to cause both neuropathy and myopathy. Although the role of β4 spectrin in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown. Here, using a muscle specific...
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Ozlem Sert Xiaoyun Ding Chuansheng Zhang Ruifa Mi Ahmet Hoke Matthew N Rasband Source Type: research
Mitochondrial calcium: An essential element for skeletal muscle performance and function
J Physiol. 2024 Mar 4. doi: 10.1113/JP286218. Online ahead of print.NO ABSTRACTPMID:38439553 | DOI:10.1113/JP286218 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Jaydeep Sharma Somnath Mondal Mahima Kumari Source Type: research
Postsynaptic β1 spectrin maintains Na < sup > + < /sup > channels at the neuromuscular junction
J Physiol. 2024 Mar 5. doi: 10.1113/JP285894. Online ahead of print.ABSTRACTSpectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 spectrin) were reported to cause both neuropathy and myopathy. Although the role of β4 spectrin in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown. Here, using a muscle specific...
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Ozlem Sert Xiaoyun Ding Chuansheng Zhang Ruifa Mi Ahmet Hoke Matthew N Rasband Source Type: research
Matching the meal and glucose impairment at acute exercise: is time on our side?
J Physiol. 2024 Mar 3. doi: 10.1113/JP286033. Online ahead of print.NO ABSTRACTPMID:38431904 | DOI:10.1113/JP286033 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 3, 2024 Category: Physiology Authors: Daniel Dos Santos Dias Guilherme Domingos Brisque Ana Paula Morelli Source Type: research
The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss
In this study we used both cell lines and a mouse model to define the pathogenic role of compound heterozygous p.W70X (c.209G>A) and p.R130S (c.390A>C) SLC26A5 variants identified in patients with moderate to profound hearing loss. As in patients, mice carrying one copy of p.R130S Slc26a5 showed OHC dysfunction and progressive degeneration, which results in congenital progressive hearing loss. This is the first functional study reporting pathogenic SLC26A5 variants and pointing to the presence of a therapeutic time window for potential clinical interventions targeting the affected OHCs before they are lost.PMID:38431...
Source: The Journal of Physiology - March 3, 2024 Category: Physiology Authors: Satoe Takahashi Yingjie Zhou Mary Ann Cheatham Kazuaki Homma Source Type: research
Cathodal bilateral transcranial direct-current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia-reperfusion injury
J Physiol. 2024 Mar 3. doi: 10.1113/JP285806. Online ahead of print.ABSTRACTNon-invasive transcranial direct-current stimulation (tDCS) is a safe ischaemic stroke therapy. Cathodal bilateral tDCS (BtDCS) is a modified tDCS approach established by us recently. Because selenium (Se) plays a crucial role in cerebral ischaemic injury, we investigated whether cathodal BtDCS conferred neuroprotection via regulating Se-dependent signalling in rat cerebral ischaemia-reperfusion (I/R) injury. We first showed that the levels of Se and its transport protein selenoprotein P (SEPP1) were reduced in the rat cortical penumbra following I...
Source: The Journal of Physiology - March 3, 2024 Category: Physiology Authors: Hui Wang Wenlong Ma Wenjie Hu Xiaohua Li Na Shen Zhuo Li Xiangyi Kong Tao Lin Jingchen Gao Ting Zhu Fengyuan Che Juan Chen Qi Wan Source Type: research
Postural threat manipulation elicits increased cortical activation during unperturbed quiet standing: Implications for fear of falling rehabilitation
J Physiol. 2024 Mar 3. doi: 10.1113/JP285796. Online ahead of print.NO ABSTRACTPMID:38431924 | DOI:10.1113/JP285796 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 3, 2024 Category: Physiology Authors: Kurnia Putri Utami Gareth D Jones Source Type: research
Matching the meal and glucose impairment at acute exercise: is time on our side?
J Physiol. 2024 Mar 3. doi: 10.1113/JP286033. Online ahead of print.NO ABSTRACTPMID:38431904 | DOI:10.1113/JP286033 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 3, 2024 Category: Physiology Authors: Daniel Dos Santos Dias Guilherme Domingos Brisque Ana Paula Morelli Source Type: research
