Systemic histone deacetylase inhibition ameliorates the aberrant responses to acute stress in socially isolated male mice
J Physiol. 2024 Mar 18. doi: 10.1113/JP285875. Online ahead of print.ABSTRACTAdverse experiences in early life can induce maladaptive responses to acute stress in later life. Chronic social isolation during adolescence is an early life adversity that can precipitate stress-related psychiatric disorders. We found that male mice after 8 weeks of adolescent social isolation (SI) have markedly increased aggression after being exposed to 2 h of restraint stress (RS), which was accompanied by a significant increase of AMPA receptor- and NMDA receptor-mediated synaptic transmission in prefrontal cortex (PFC) pyramidal neurons of ...
Source: The Journal of Physiology - March 19, 2024 Category: Physiology Authors: Luis Gustavo Hernandez Carballo Pei Li Rachel Senek Zhen Yan Source Type: research
Differential utilisation of subcellular skeletal muscle glycogen pools: a comparative analysis between 1 and 15 min of maximal exercise
In conclusion, distinct subcellular glycogen pools were differentially utilised during 1-min and 15-min maximal cycling exercise. Additionally, lowered carbohydrate and energy consumption after glycogen-depleting exercise altered glycogen storage by reducing particle size and numerical density, depending on subcellular localisation. KEY POINTS: In human skeletal muscle, glycogen particles are localised in distinct subcellular compartments, referred to as intermyofibrillar, intramyofibrillar and subsarcolemmal pools. The intermyofibrillar and subsarcolemmal pools are close to mitochondria, while the intramyofibrillar pool i...
Source: The Journal of Physiology - March 19, 2024 Category: Physiology Authors: Camilla Tvede Schytz Niels Ørtenblad Kasper Degn Gejl Joachim Nielsen Source Type: research
Antagonism of 5-HT < sub > 2 < /sub > receptors attenuates self-sustained firing of human motor units
J Physiol. 2024 Mar 19. doi: 10.1113/JP285867. Online ahead of print.ABSTRACT5-HT2 receptors on motoneurones play a critical role in facilitating persistent inward currents (PICs). Although facilitation of PICs can enhance self-sustained firing after periods of excitation, the relationship between 5-HT2 receptor activity and self-sustained firing in human motor units (MUs) has not been resolved. MU activity was assessed from the tibialis anterior of 10 healthy adults (24.9 ± 2.8 years) during two contraction protocols. Both protocols featured steady-state isometric contractions with constant descending drive to the motone...
Source: The Journal of Physiology - March 19, 2024 Category: Physiology Authors: Benjamin I Goodlich Gregory E P Pearcey Alessandro Del Vecchio Sean A Horan Justin J Kavanagh Source Type: research
Systemic histone deacetylase inhibition ameliorates the aberrant responses to acute stress in socially isolated male mice
J Physiol. 2024 Mar 18. doi: 10.1113/JP285875. Online ahead of print.ABSTRACTAdverse experiences in early life can induce maladaptive responses to acute stress in later life. Chronic social isolation during adolescence is an early life adversity that can precipitate stress-related psychiatric disorders. We found that male mice after 8 weeks of adolescent social isolation (SI) have markedly increased aggression after being exposed to 2 h of restraint stress (RS), which was accompanied by a significant increase of AMPA receptor- and NMDA receptor-mediated synaptic transmission in prefrontal cortex (PFC) pyramidal neurons of ...
Source: The Journal of Physiology - March 19, 2024 Category: Physiology Authors: Luis Gustavo Hernandez Carballo Pei Li Rachel Senek Zhen Yan Source Type: research
Differential utilisation of subcellular skeletal muscle glycogen pools: a comparative analysis between 1 and 15 min of maximal exercise
In conclusion, distinct subcellular glycogen pools were differentially utilised during 1-min and 15-min maximal cycling exercise. Additionally, lowered carbohydrate and energy consumption after glycogen-depleting exercise altered glycogen storage by reducing particle size and numerical density, depending on subcellular localisation. KEY POINTS: In human skeletal muscle, glycogen particles are localised in distinct subcellular compartments, referred to as intermyofibrillar, intramyofibrillar and subsarcolemmal pools. The intermyofibrillar and subsarcolemmal pools are close to mitochondria, while the intramyofibrillar pool i...
Source: The Journal of Physiology - March 19, 2024 Category: Physiology Authors: Camilla Tvede Schytz Niels Ørtenblad Kasper Degn Gejl Joachim Nielsen Source Type: research
Antagonism of 5-HT < sub > 2 < /sub > receptors attenuates self-sustained firing of human motor units
J Physiol. 2024 Mar 19. doi: 10.1113/JP285867. Online ahead of print.ABSTRACT5-HT2 receptors on motoneurones play a critical role in facilitating persistent inward currents (PICs). Although facilitation of PICs can enhance self-sustained firing after periods of excitation, the relationship between 5-HT2 receptor activity and self-sustained firing in human motor units (MUs) has not been resolved. MU activity was assessed from the tibialis anterior of 10 healthy adults (24.9 ± 2.8 years) during two contraction protocols. Both protocols featured steady-state isometric contractions with constant descending drive to the motone...
Source: The Journal of Physiology - March 19, 2024 Category: Physiology Authors: Benjamin I Goodlich Gregory E P Pearcey Alessandro Del Vecchio Sean A Horan Justin J Kavanagh Source Type: research
Distinct electrophysiological properties of long-range GABAergic and glutamatergic neurons from the lateral amygdala to the auditory cortex of the mouse
This study paves the way for a better understanding of the growing complexity of the cortico-amygdala-cortico circuit.PMID:38493320 | DOI:10.1113/JP286094 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Alice Bertero Alfonso Junior Apicella Source Type: research
Muscle fibre typology affects whole-body metabolic rate during isolated muscle contractions and human locomotion
J Physiol. 2024 Mar 17. doi: 10.1113/JP285846. Online ahead of print.ABSTRACTThe wide variation in muscle fibre type distribution across individuals, along with the very different energy consumption rates in slow versus fast muscle fibres, suggests that muscle fibre typology contributes to inter-individual differences in metabolic rate during exercise. However, this has been hard to demonstrate due to the gap between a single muscle fibre and full-body exercises. We investigated the isolated effect of triceps surae muscle contraction velocity on whole-body metabolic rate during cyclic contractions in individuals a priori s...
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Wannes Swinnen Eline Lievens Wouter Hoogkamer Friedl De Groote Wim Derave Benedicte Vanwanseele Source Type: research
Renin the show: neuropilin-1's role in regulating juxtaglomerular cells
J Physiol. 2024 Mar 17. doi: 10.1113/JP286394. Online ahead of print.NO ABSTRACTPMID:38493356 | DOI:10.1113/JP286394 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Kyle H Moore Bryan K Becker Source Type: research
Distinct electrophysiological properties of long-range GABAergic and glutamatergic neurons from the lateral amygdala to the auditory cortex of the mouse
This study paves the way for a better understanding of the growing complexity of the cortico-amygdala-cortico circuit.PMID:38493320 | DOI:10.1113/JP286094 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Alice Bertero Alfonso Junior Apicella Source Type: research
Muscle fibre typology affects whole-body metabolic rate during isolated muscle contractions and human locomotion
J Physiol. 2024 Mar 17. doi: 10.1113/JP285846. Online ahead of print.ABSTRACTThe wide variation in muscle fibre type distribution across individuals, along with the very different energy consumption rates in slow versus fast muscle fibres, suggests that muscle fibre typology contributes to inter-individual differences in metabolic rate during exercise. However, this has been hard to demonstrate due to the gap between a single muscle fibre and full-body exercises. We investigated the isolated effect of triceps surae muscle contraction velocity on whole-body metabolic rate during cyclic contractions in individuals a priori s...
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Wannes Swinnen Eline Lievens Wouter Hoogkamer Friedl De Groote Wim Derave Benedicte Vanwanseele Source Type: research
Renin the show: neuropilin-1's role in regulating juxtaglomerular cells
J Physiol. 2024 Mar 17. doi: 10.1113/JP286394. Online ahead of print.NO ABSTRACTPMID:38493356 | DOI:10.1113/JP286394 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Kyle H Moore Bryan K Becker Source Type: research
Distinct electrophysiological properties of long-range GABAergic and glutamatergic neurons from the lateral amygdala to the auditory cortex of the mouse
This study paves the way for a better understanding of the growing complexity of the cortico-amygdala-cortico circuit.PMID:38493320 | DOI:10.1113/JP286094 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 17, 2024 Category: Physiology Authors: Alice Bertero Alfonso Junior Apicella Source Type: research
Cyclic nucleotide-induced bidirectional long-term synaptic plasticity in Drosophila mushroom body
J Physiol. 2024 Mar 15. doi: 10.1113/JP285745. Online ahead of print.ABSTRACTActivation of the cAMP pathway is one of the common mechanisms underlying long-term potentiation (LTP). In the Drosophila mushroom body, simultaneous activation of odour-coding Kenyon cells (KCs) and reinforcement-coding dopaminergic neurons activates adenylyl cyclase in KC presynaptic terminals, which is believed to trigger synaptic plasticity underlying olfactory associative learning. However, learning induces long-term depression (LTD) at these synapses, contradicting the universal role of cAMP as a facilitator of transmission. Here, we develop...
Source: The Journal of Physiology - March 15, 2024 Category: Physiology Authors: Daichi Yamada Andrew M Davidson Toshihide Hige Source Type: research
Cyclic nucleotide-induced bidirectional long-term synaptic plasticity in Drosophila mushroom body
J Physiol. 2024 Mar 15. doi: 10.1113/JP285745. Online ahead of print.ABSTRACTActivation of the cAMP pathway is one of the common mechanisms underlying long-term potentiation (LTP). In the Drosophila mushroom body, simultaneous activation of odour-coding Kenyon cells (KCs) and reinforcement-coding dopaminergic neurons activates adenylyl cyclase in KC presynaptic terminals, which is believed to trigger synaptic plasticity underlying olfactory associative learning. However, learning induces long-term depression (LTD) at these synapses, contradicting the universal role of cAMP as a facilitator of transmission. Here, we develop...
Source: The Journal of Physiology - March 15, 2024 Category: Physiology Authors: Daichi Yamada Andrew M Davidson Toshihide Hige Source Type: research
