Circadian patterns of behaviour change during pregnancy in mice
In conclusion, increased food intake during pregnancy reflects increased amplitude of eating behaviour, without longer duration. Decreases in activity also contribute to positive energy balance in pregnancy, with delays to all measured behaviours evident from mid-pregnancy onwards. KEY POINTS: Circadian rhythms synchronise daily behaviours including eating, drinking and sleep, but how these change in pregnancy is unclear. Food intake increased, with delays in peaks of food intake behaviour late in the light phase from days 6.5 to 12.5 of pregnancy, in comparison to the non-pregnant group. The onset of activity after lights...
Source: The Journal of Physiology - March 13, 2024 Category: Physiology Authors: Georgia S Clarke Andrew D Vincent Sharon R Ladyman Kathryn L Gatford Amanda J Page Source Type: research
FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling
J Physiol. 2024 Mar 11. doi: 10.1113/JP285479. Online ahead of print.ABSTRACTFibroblast growth factor-2 (FGF2) is involved in the regulation of affective behaviour and shows antidepressant effects through the Akt and extracellular signal regulated kinase (ERK) 1/2 pathways. Nudix hydrolase 6 (NUDT6) protein is encoded from FGF2 gene's antisense strand and its role in the regulation of affective behaviour is unknown. Here, we overexpressed NUDT6 in the hippocampus and investigated its behavioural effects and the underlying molecular mechanisms affecting the behaviour. We showed that increasing hippocampal NUDT6 results in d...
Source: The Journal of Physiology - March 12, 2024 Category: Physiology Authors: Burak Uzay Asl ıhan Bahadır-Varol Fatma Özlem Hökelekli Murat Y ılmaz Emre Cem Esen Koray Ba şar Yavuz Ayhan Turgay Dalkara Emine Eren-Ko çak Source Type: research
FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling
J Physiol. 2024 Mar 11. doi: 10.1113/JP285479. Online ahead of print.ABSTRACTFibroblast growth factor-2 (FGF2) is involved in the regulation of affective behaviour and shows antidepressant effects through the Akt and extracellular signal regulated kinase (ERK) 1/2 pathways. Nudix hydrolase 6 (NUDT6) protein is encoded from FGF2 gene's antisense strand and its role in the regulation of affective behaviour is unknown. Here, we overexpressed NUDT6 in the hippocampus and investigated its behavioural effects and the underlying molecular mechanisms affecting the behaviour. We showed that increasing hippocampal NUDT6 results in d...
Source: The Journal of Physiology - March 12, 2024 Category: Physiology Authors: Burak Uzay Asl ıhan Bahadır-Varol Fatma Özlem Hökelekli Murat Y ılmaz Emre Cem Esen Koray Ba şar Yavuz Ayhan Turgay Dalkara Emine Eren-Ko çak Source Type: research
Hypoxic cerebrovascular oxidative-nitrosative stress: Take my breath away
J Physiol. 2024 Mar 11. doi: 10.1113/JP286304. Online ahead of print.NO ABSTRACTPMID:38466023 | DOI:10.1113/JP286304 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 11, 2024 Category: Physiology Authors: Kirsten M øller Source Type: research
Hypoxic cerebrovascular oxidative-nitrosative stress: Take my breath away
J Physiol. 2024 Mar 11. doi: 10.1113/JP286304. Online ahead of print.NO ABSTRACTPMID:38466023 | DOI:10.1113/JP286304 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 11, 2024 Category: Physiology Authors: Kirsten M øller Source Type: research
Sex differences in lipid metabolism may explain disparities in cardiometabolic disease prevalence with sleep apnoea
J Physiol. 2024 Mar 9. doi: 10.1113/JP286261. Online ahead of print.NO ABSTRACTPMID:38460123 | DOI:10.1113/JP286261 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 9, 2024 Category: Physiology Authors: Claire E Berryman Source Type: research
Sex differences in lipid metabolism may explain disparities in cardiometabolic disease prevalence with sleep apnoea
J Physiol. 2024 Mar 9. doi: 10.1113/JP286261. Online ahead of print.NO ABSTRACTPMID:38460123 | DOI:10.1113/JP286261 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 9, 2024 Category: Physiology Authors: Claire E Berryman Source Type: research
PIEZO ion channels: force sensors of the interoceptive nervous system
J Physiol. 2024 Mar 8. doi: 10.1113/JP284077. Online ahead of print.ABSTRACTMany organs are designed to move: the heart pumps each second, the gastrointestinal tract squeezes and churns to digest food, and we contract and relax skeletal muscles to move our bodies. Sensory neurons of the peripheral nervous system detect signals from bodily tissues, including the forces generated by these movements, to control physiology. The processing of these internal signals is called interoception, but this is a broad term that includes a wide variety of both chemical and mechanical sensory processes. Mechanical senses are understudied,...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Yasmeen M F Hamed Britya Ghosh Kara L Marshall Source Type: research
Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support
In conclusion, mechanical LV support increases infarct coronary flow by extending diastole and augmenting coronary driving pressure. These changes were mainly driven by reduced LV diastolic pressure, indicating that the key regulator of coronary flow under mechanical LV support is downstream of the coronary artery, rather than upstream. Our study highlights the importance of LV diastolic pressure in infarct coronary flow regulation. KEY POINTS: Restoring ischaemic myocardial tissue perfusion is crucial for minimizing infarct size. Although mechanical left ventricular (LV) support has been suggested to improve infarct coron...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Tomoki Sakata Spyros A Mavropoulos Renata Mazurek Francisco J Romeo Anjali J Ravichandran Jonas M Marx Taro Kariya Kiyotake Ishikawa Source Type: research
Ocular surface information seen from the somatosensory thalamus and cortex
J Physiol. 2024 Mar 8. doi: 10.1113/JP285008. Online ahead of print.ABSTRACTOcular Surface (OS) somatosensory innervation detects external stimuli producing perceptions, such as pain or dryness, the most relevant symptoms in many OS pathologies. Nevertheless, little is known about the central nervous system circuits involved in these perceptions, and how they integrate multimodal inputs in general. Here, we aim to describe the thalamic and cortical activity in response to OS stimulation of different modalities. Electrophysiological extracellular recordings in anaesthetized rats were used to record neural activity, while sa...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Enrique Velasco Marta Zaforas M Carmen Acosta Juana Gallar Juan Aguilar Source Type: research
PIEZO ion channels: force sensors of the interoceptive nervous system
J Physiol. 2024 Mar 8. doi: 10.1113/JP284077. Online ahead of print.ABSTRACTMany organs are designed to move: the heart pumps each second, the gastrointestinal tract squeezes and churns to digest food, and we contract and relax skeletal muscles to move our bodies. Sensory neurons of the peripheral nervous system detect signals from bodily tissues, including the forces generated by these movements, to control physiology. The processing of these internal signals is called interoception, but this is a broad term that includes a wide variety of both chemical and mechanical sensory processes. Mechanical senses are understudied,...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Yasmeen M F Hamed Britya Ghosh Kara L Marshall Source Type: research
Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support
In conclusion, mechanical LV support increases infarct coronary flow by extending diastole and augmenting coronary driving pressure. These changes were mainly driven by reduced LV diastolic pressure, indicating that the key regulator of coronary flow under mechanical LV support is downstream of the coronary artery, rather than upstream. Our study highlights the importance of LV diastolic pressure in infarct coronary flow regulation. KEY POINTS: Restoring ischaemic myocardial tissue perfusion is crucial for minimizing infarct size. Although mechanical left ventricular (LV) support has been suggested to improve infarct coron...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Tomoki Sakata Spyros A Mavropoulos Renata Mazurek Francisco J Romeo Anjali J Ravichandran Jonas M Marx Taro Kariya Kiyotake Ishikawa Source Type: research
Ocular surface information seen from the somatosensory thalamus and cortex
J Physiol. 2024 Mar 8. doi: 10.1113/JP285008. Online ahead of print.ABSTRACTOcular Surface (OS) somatosensory innervation detects external stimuli producing perceptions, such as pain or dryness, the most relevant symptoms in many OS pathologies. Nevertheless, little is known about the central nervous system circuits involved in these perceptions, and how they integrate multimodal inputs in general. Here, we aim to describe the thalamic and cortical activity in response to OS stimulation of different modalities. Electrophysiological extracellular recordings in anaesthetized rats were used to record neural activity, while sa...
Source: The Journal of Physiology - March 8, 2024 Category: Physiology Authors: Enrique Velasco Marta Zaforas M Carmen Acosta Juana Gallar Juan Aguilar Source Type: research
Mitochondrial calcium: An essential element for skeletal muscle performance and function
J Physiol. 2024 Mar 4. doi: 10.1113/JP286218. Online ahead of print.NO ABSTRACTPMID:38439553 | DOI:10.1113/JP286218 (Source: The Journal of Physiology)
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Jaydeep Sharma Somnath Mondal Mahima Kumari Source Type: research
Postsynaptic β1 spectrin maintains Na < sup > + < /sup > channels at the neuromuscular junction
J Physiol. 2024 Mar 5. doi: 10.1113/JP285894. Online ahead of print.ABSTRACTSpectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4 spectrin) were reported to cause both neuropathy and myopathy. Although the role of β4 spectrin in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown. Here, using a muscle specific...
Source: The Journal of Physiology - March 5, 2024 Category: Physiology Authors: Ozlem Sert Xiaoyun Ding Chuansheng Zhang Ruifa Mi Ahmet Hoke Matthew N Rasband Source Type: research
