Correction to 'Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells'
J Physiol. 2024 Jan 24. doi: 10.1113/JP286256. Online ahead of print.NO ABSTRACTPMID:38265853 | DOI:10.1113/JP286256 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 24, 2024 Category: Physiology Source Type: research
The getting of wisdom
J Physiol. 2024 Jan 23. doi: 10.1113/JP286253. Online ahead of print.NO ABSTRACTPMID:38261450 | DOI:10.1113/JP286253 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 23, 2024 Category: Physiology Authors: Vaughan G Macefield Source Type: research
Under pressure: examining the effect of modulating intrathoracic pressure swings on cardiac output
J Physiol. 2024 Jan 23. doi: 10.1113/JP285976. Online ahead of print.NO ABSTRACTPMID:38261651 | DOI:10.1113/JP285976 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 23, 2024 Category: Physiology Authors: Jona B Bernal Joshua D R Downer Vanessa H J Lin Source Type: research
Vertebral level specific modulation of paraspinal muscle activity based on vestibular signals during walking
This study aimed to investigate how vestibular signals affect paraspinal muscle activity at different vertebral levels during walking with preferred and narrow step width. Sixteen healthy participants were recruited. Participants walked on a treadmill for 8 min at 78 steps/min and 2.8 km/h, at two different step width, either with or without EVS. Bipolar electromyography was recorded bilaterally from the paraspinal muscles at eight vertebral levels from cervical to lumbar. Coherence, gain, and delay of EVS and EMG responses were determined. Significant EVS-EMG coupling (P < 0.01) was found at ipsilateral and/or contrala...
Source: The Journal of Physiology - January 22, 2024 Category: Physiology Authors: Yiyuan C Li Sjoerd M Bruijn Koen K Lemaire Simon Brumagne Jaap H van Die ën Source Type: research
God doesn't play poker
J Physiol. 2024 Jan 17. doi: 10.1113/JP286171. Online ahead of print.NO ABSTRACTPMID:38230975 | DOI:10.1113/JP286171 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 17, 2024 Category: Physiology Authors: Mesut Tez Source Type: research
The impact of acute exercise on appetite regulation: unravelling the potential involvement of gut microbial activity
J Physiol. 2024 Feb;602(3):529-530. doi: 10.1113/JP286101. Epub 2024 Jan 16.NO ABSTRACTPMID:38226960 | DOI:10.1113/JP286101 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 16, 2024 Category: Physiology Authors: James Frampton Jose Ivan Serrano-Contreras Isabel Garcia-Perez Georgia Franco-Becker Jack Penhaligan Abbigail S Y Tan Ana Claudia Cepas de Oliveira Annabelle J Milner Kevin G Murphy Gary Frost Edward S Chambers Source Type: research
Comprehensive measurement of muscle maximal oxygen uptake determinants: insights and application
J Physiol. 2024 Feb;602(3):423-425. doi: 10.1113/JP286095. Epub 2024 Jan 15.NO ABSTRACTPMID:38224247 | DOI:10.1113/JP286095 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 15, 2024 Category: Physiology Authors: Kevin L Webb Solomiia Zaremba Wyatt W Pruter Alex J Miller Kylie N Sears Source Type: research
Exosomal DNA: an alternative vehicle for soma-to-germline communication?
J Physiol. 2024 Jan 15. doi: 10.1113/JP286170. Online ahead of print.NO ABSTRACTPMID:38224265 | DOI:10.1113/JP286170 (Source: The Journal of Physiology)
Source: The Journal of Physiology - January 15, 2024 Category: Physiology Authors: Haili Sun Yongsheng Liu Source Type: research
Small peptides: could they have a big role in metabolism and the response to exercise?
J Physiol. 2024 Jan 9. doi: 10.1113/JP283214. Online ahead of print.ABSTRACTExercise is a powerful non-pharmacological intervention for the treatment and prevention of numerous chronic diseases. Contracting skeletal muscles provoke widespread perturbations in numerous cells, tissues and organs, which stimulate multiple integrated adaptations that ultimately contribute to the many health benefits associated with regular exercise. Despite much research, the molecular mechanisms driving such changes are not completely resolved. Technological advancements beginning in the early 1960s have opened new avenues to explore the mech...
Source: The Journal of Physiology - January 10, 2024 Category: Physiology Authors: Muhammed M Atakan İbrahim Türkel Berkay Özerkliğ Şükran N Koşar Dale F Taylor Xu Yan David J Bishop Source Type: research
Pacing intracellular Ca < sup > 2+ < /sup > signals in exocrine acinar cells
J Physiol. 2024 Jan 10. doi: 10.1113/JP284755. Online ahead of print.ABSTRACTAn increase in intracellular [Ca2+ ] in exocrine acinar cells resident in the salivary glands or pancreas is a fundamental event that drives fluid secretion and exocytosis of proteins. Stimulation with secretagogues initiates Ca2+ signals with precise spatiotemporal properties thought to be important for driving physiological output. Both in vitro, in acutely isolated acini, and in vivo, in animals expressing genetically encoded indicators, individual cells appear specialized to initiate Ca2+ signals upon stimulation. Furthermore, these signals ap...
Source: The Journal of Physiology - January 10, 2024 Category: Physiology Authors: David I Yule Takahiro Takano Source Type: research
Small peptides: could they have a big role in metabolism and the response to exercise?
J Physiol. 2024 Jan 9. doi: 10.1113/JP283214. Online ahead of print.ABSTRACTExercise is a powerful non-pharmacological intervention for the treatment and prevention of numerous chronic diseases. Contracting skeletal muscles provoke widespread perturbations in numerous cells, tissues and organs, which stimulate multiple integrated adaptations that ultimately contribute to the many health benefits associated with regular exercise. Despite much research, the molecular mechanisms driving such changes are not completely resolved. Technological advancements beginning in the early 1960s have opened new avenues to explore the mech...
Source: The Journal of Physiology - January 10, 2024 Category: Physiology Authors: Muhammed M Atakan İbrahim Türkel Berkay Özerkliğ Şükran N Koşar Dale F Taylor Xu Yan David J Bishop Source Type: research
Pacing intracellular Ca < sup > 2+ < /sup > signals in exocrine acinar cells
J Physiol. 2024 Jan 10. doi: 10.1113/JP284755. Online ahead of print.ABSTRACTAn increase in intracellular [Ca2+ ] in exocrine acinar cells resident in the salivary glands or pancreas is a fundamental event that drives fluid secretion and exocytosis of proteins. Stimulation with secretagogues initiates Ca2+ signals with precise spatiotemporal properties thought to be important for driving physiological output. Both in vitro, in acutely isolated acini, and in vivo, in animals expressing genetically encoded indicators, individual cells appear specialized to initiate Ca2+ signals upon stimulation. Furthermore, these signals ap...
Source: The Journal of Physiology - January 10, 2024 Category: Physiology Authors: David I Yule Takahiro Takano Source Type: research
Evolutionary feedback from the environment shapes mechanisms that generate genome variation
J Physiol. 2024 Jan 9. doi: 10.1113/JP284411. Online ahead of print.ABSTRACTDarwin recognized that 'a grand and almost untrodden field of inquiry will be opened, on the causes and laws of variation.' However, because the Modern Synthesis assumes that the intrinsic probability of any individual mutation is unrelated to that mutation's potential adaptive value, attention has been focused on selection rather than on the intrinsic generation of variation. Yet many examples illustrate that the term 'random' mutation, as widely understood, is inaccurate. The probabilities of distinct classes of variation are neither evenly distr...
Source: The Journal of Physiology - January 9, 2024 Category: Physiology Authors: Lynn Helena Caporale Source Type: research
Differential effects of mechano-electric feedback mechanisms on whole-heart activation, repolarization, and tension
In conclusion, we found that mechano-electric feedback changes activation and repolarization patterns throughout the heart during sinus rhythm and lead to a markedly more heterogeneous electrophysiological substrate. KEY POINTS: The electrophysiological and mechanical function of the heart are tightly interrelated by excitation-contraction coupling (ECC) in the forward direction and mechano-electric feedback (MEF) in the reverse direction. While ECC is considered in many state-of-the-art computational models of cardiac electromechanics, less is known about the effect of different MEF mechanisms. Accounting for calcium boun...
Source: The Journal of Physiology - January 8, 2024 Category: Physiology Authors: Tobias Gerach Axel Loewe Source Type: research
Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor
In conclusion, S1159F and S1159P are gating variants, which also affect CFTR processing and conduction, but not stability, necessitating the use of combinations of CFTR modulators to optimally restore their channel activity. KEY POINTS: Dysfunction of the ion channel cystic fibrosis transmembrane conductance regulator (CFTR) causes the genetic disease cystic fibrosis (CF). This study investigated two rare pathogenic CFTR variants, S1159F and S1159P, which affect the same amino acid in CFTR, to understand the molecular basis of disease and response to the CFTR-targeted therapy ivacaftor. Both rare variants diminished CFTR f...
Source: The Journal of Physiology - January 8, 2024 Category: Physiology Authors: Hongyu Li Mayuree Rodrat Majid K Al-Salmani Diana-Florentina Veselu Sangwoo T Han Karen S Raraigh Garry R Cutting David N Sheppard Source Type: research
