Scheduled for surgery? Prescription: exercise!
J Physiol. 2023 Dec 25. doi: 10.1113/JP285971. Online ahead of print.NO ABSTRACTPMID:38146196 | DOI:10.1113/JP285971 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 26, 2023 Category: Physiology Authors: Casper Soendenbroe Grith H øjfeldt Source Type: research
Expedition 5300: limits of human adaptations in the highest city in the world
J Physiol. 2023 Dec 26. doi: 10.1113/JP284550. Online ahead of print.ABSTRACTExposure to chronic hypobaric hypoxia imposes a significant physiological burden to more than 80 million humans living above 2500 m throughout the world. Among them, 50 000 live in the world's highest city, La Rinconada, located at 5000-5300 m in southern Peru. Expedition 5300 is the first scientific and medical programme led in La Rinconada to investigate the physiological adaptations and altitude-related health issues in this unique population. Dwellers from La Rinconada have very high haemoglobin concentration (20.3 ± 2.4 g/dL; n = 57) and tho...
Source: The Journal of Physiology - December 26, 2023 Category: Physiology Authors: Benoit Champigneulle Julien V Brugniaux Emeric Stauffer St éphane Doutreleau Michael Furian Elisa Perger Alessandra Pina S ébastien Baillieul Blandine Deschamps Ivan Hancco Philippe Connes Paul Robach Aur élien Pichon Samuel Verges Source Type: research
What can insects teach us about hearing loss?
J Physiol. 2023 Dec 21. doi: 10.1113/JP281281. Online ahead of print.ABSTRACTOver the last three decades, insects have been utilized to provide a deep and fundamental understanding of many human diseases and disorders. Here, we present arguments for insects as models to understand general principles underlying hearing loss. Despite ∼600 million years since the last common ancestor of vertebrates and invertebrates, we share an overwhelming degree of genetic homology particularly with respect to auditory organ development and maintenance. Despite the anatomical differences between human and insect auditory organs, both sha...
Source: The Journal of Physiology - December 21, 2023 Category: Physiology Authors: Ben Warren Daniel Eberl Source Type: research
What can insects teach us about hearing loss?
J Physiol. 2023 Dec 21. doi: 10.1113/JP281281. Online ahead of print.ABSTRACTOver the last three decades, insects have been utilized to provide a deep and fundamental understanding of many human diseases and disorders. Here, we present arguments for insects as models to understand general principles underlying hearing loss. Despite ∼600 million years since the last common ancestor of vertebrates and invertebrates, we share an overwhelming degree of genetic homology particularly with respect to auditory organ development and maintenance. Despite the anatomical differences between human and insect auditory organs, both sha...
Source: The Journal of Physiology - December 21, 2023 Category: Physiology Authors: Ben Warren Daniel Eberl Source Type: research
What can insects teach us about hearing loss?
J Physiol. 2023 Dec 21. doi: 10.1113/JP281281. Online ahead of print.ABSTRACTOver the last three decades, insects have been utilized to provide a deep and fundamental understanding of many human diseases and disorders. Here, we present arguments for insects as models to understand general principles underlying hearing loss. Despite ∼600 million years since the last common ancestor of vertebrates and invertebrates, we share an overwhelming degree of genetic homology particularly with respect to auditory organ development and maintenance. Despite the anatomical differences between human and insect auditory organs, both sha...
Source: The Journal of Physiology - December 21, 2023 Category: Physiology Authors: Ben Warren Daniel Eberl Source Type: research
What can insects teach us about hearing loss?
J Physiol. 2023 Dec 21. doi: 10.1113/JP281281. Online ahead of print.ABSTRACTOver the last three decades, insects have been utilized to provide a deep and fundamental understanding of many human diseases and disorders. Here, we present arguments for insects as models to understand general principles underlying hearing loss. Despite ∼600 million years since the last common ancestor of vertebrates and invertebrates, we share an overwhelming degree of genetic homology particularly with respect to auditory organ development and maintenance. Despite the anatomical differences between human and insect auditory organs, both sha...
Source: The Journal of Physiology - December 21, 2023 Category: Physiology Authors: Ben Warren Daniel Eberl Source Type: research
Impaired cerebrovascular CO < sub > 2 < /sub > reactivity at high altitude in prematurely born adults
In conclusion, exposure to high altitude revealed different cerebrovascular responses in preterm- compared with term-born adults, despite similar ventilatory responses. These findings suggest a blunted cerebrovascular response at high altitude in preterm-born adults, which might predispose these individuals to an increased risk of high-altitude illnesses. KEY POINTS: Cerebral haemodynamics and cerebrovascular reactivity in normoxia are known to be similar between term-born and prematurely born adults. In contrast, acute exposure to high altitude unveiled different cerebrovascular responses to hypoxia, hypercapnia and hypoc...
Source: The Journal of Physiology - December 20, 2023 Category: Physiology Authors: Giorgio Manferdelli Benjamin J Narang Nicolas Bourdillon Guido Giardini Tadej Debevec Gr égoire P Millet Source Type: research
Impaired cerebrovascular CO < sub > 2 < /sub > reactivity at high altitude in prematurely born adults
In conclusion, exposure to high altitude revealed different cerebrovascular responses in preterm- compared with term-born adults, despite similar ventilatory responses. These findings suggest a blunted cerebrovascular response at high altitude in preterm-born adults, which might predispose these individuals to an increased risk of high-altitude illnesses. KEY POINTS: Cerebral haemodynamics and cerebrovascular reactivity in normoxia are known to be similar between term-born and prematurely born adults. In contrast, acute exposure to high altitude unveiled different cerebrovascular responses to hypoxia, hypercapnia and hypoc...
Source: The Journal of Physiology - December 20, 2023 Category: Physiology Authors: Giorgio Manferdelli Benjamin J Narang Nicolas Bourdillon Guido Giardini Tadej Debevec Gr égoire P Millet Source Type: research
Confidence intervals are not a way of moving beyond P values
J Physiol. 2023 Dec 19. doi: 10.1113/JP286050. Online ahead of print.NO ABSTRACTPMID:38112447 | DOI:10.1113/JP286050 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 19, 2023 Category: Physiology Authors: Aaron R Caldwell Matthew S Tenan Source Type: research
Correction to 'Nitrate attenuates high fat diet-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission'
J Physiol. 2023 Dec 19. doi: 10.1113/JP286100. Online ahead of print.NO ABSTRACTPMID:38112511 | DOI:10.1113/JP286100 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 19, 2023 Category: Physiology Source Type: research
Is it time to expand the scope of the autonomic nervous system?
J Physiol. 2023 Dec 19. doi: 10.1113/JP286077. Online ahead of print.NO ABSTRACTPMID:38113314 | DOI:10.1113/JP286077 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 19, 2023 Category: Physiology Authors: Vaughan G Macefield Source Type: research
Confidence intervals are not a way of moving beyond P values
J Physiol. 2023 Dec 19. doi: 10.1113/JP286050. Online ahead of print.NO ABSTRACTPMID:38112447 | DOI:10.1113/JP286050 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 19, 2023 Category: Physiology Authors: Aaron R Caldwell Matthew S Tenan Source Type: research
Correction to 'Nitrate attenuates high fat diet-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission'
J Physiol. 2023 Dec 19. doi: 10.1113/JP286100. Online ahead of print.NO ABSTRACTPMID:38112511 | DOI:10.1113/JP286100 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 19, 2023 Category: Physiology Source Type: research
Is it time to expand the scope of the autonomic nervous system?
J Physiol. 2023 Dec 19. doi: 10.1113/JP286077. Online ahead of print.NO ABSTRACTPMID:38113314 | DOI:10.1113/JP286077 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 19, 2023 Category: Physiology Authors: Vaughan G Macefield Source Type: research
Do peripheral and central sites independently contribute to the CO < sub > 2 < /sub > stimulus for breathing?
J Physiol. 2023 Dec 16. doi: 10.1113/JP285652. Online ahead of print.NO ABSTRACTPMID:38103001 | DOI:10.1113/JP285652 (Source: The Journal of Physiology)
Source: The Journal of Physiology - December 16, 2023 Category: Physiology Authors: Hubert V Forster Matthew R Hodges Source Type: research
