Haptoglobin Phenotype Is Associated With HDL (High-Density Lipoprotein)-Bound Hemoglobin Content and Coronary Endothelial Dysfunction in Patients With Mild Nonobstructive Coronary Artery Disease.
Abstract Objective- Coronary endothelial dysfunction (ED) is an early stage of atherosclerosis and is associated with impaired HDL (high-density lipoprotein) function. A functional polymorphism at the Hp (haptoglobin) gene locus (rs72294371) has been associated with marked differences in HDL structure and function. We sought to determine whether Hp phenotype was associated with coronary ED and whether the amount of hemoglobin (Hb) tethered to HDL via Hp was Hp-type dependent and associated with ED. Approach and Results- Microvascular and epicardial coronary endothelial function was assessed in 338 individuals with...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Asleh R, Levy AP, Levy NS, Asleh A, Goldenstein H, Segol I, Gulati R, Lerman LO, Lerman A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension.
Abstract In pulmonary arterial hypertension (PAH), the Warburg effect (glycolytic shift) and mitochondrial fission are determinants of phenotype alterations characteristic of the disease, such as proliferation, apoptosis resistance, migration, endothelial-mesenchymal transition, and ECM (extracellular matrix) stiffness. Current therapies, focusing largely on vasodilation and antithrombotic protection, do not restore these aberrant phenotypes suggesting that additional pathways need be targeted. The multifactorial nature of PAH suggests epigenetic changes as potential determinants of vascular remodeling. Transgener...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Napoli C, Benincasa G, Loscalzo J Tags: Arterioscler Thromb Vasc Biol Source Type: research

Race-Based Differences in Lipoprotein(a)-Associated Risk of Carotid Atherosclerosis.
Abstract Objective- Lp(a) [lipoprotein(a)] is a well-described risk factor for atherosclerosis, but Lp(a)-associated risk may vary by race/ethnicity. We aimed to determine whether race/ethnicity modifies Lp(a)-related risk of carotid atherosclerotic plaque outcomes among black, white, Chinese, and Hispanic individuals. Approach and Results- Carotid plaque presence and score were assessed by ultrasonography at baseline (n=5155) and following a median 9.4 year period (n=3380) in MESA (Multi-Ethnic Study of Atherosclerosis) participants. Lp(a) concentrations were measured by immunoassay and examined as a continuous a...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Steffen BT, Thanassoulis G, Duprez D, Stein JH, Karger AB, Tattersall MC, Kaufman JD, Guan W, Tsai MY Tags: Arterioscler Thromb Vasc Biol Source Type: research

Osteopontin in Vascular Disease.
Abstract Inflammatory cytokines are necessary for an acute response to injury and the progressive healing process. However, when this acute response does not resolve and becomes chronic, the same proteins that once promoted healing then contribute to chronic inflammatory pathologies, such as atherosclerosis. OPN (Osteopontin) is a secreted matricellular cytokine that signals through integrin and CD44 receptors, is highly upregulated in acute and chronic inflammatory settings, and has been implicated in physiological and pathophysiologic processes. Evidence from the literature suggests that OPN may fit within the G...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Lok ZSY, Lyle AN Tags: Arterioscler Thromb Vasc Biol Source Type: research

Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease.
Conclusions- Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids. PMID: 30727755 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Selective Inhibition of PAR4 (Protease-Activated Receptor 4)-Mediated Platelet Activation by a Synthetic Nonanticoagulant Heparin Analog.
Conclusions- SCH-28, a synthetic small-molecular and nonanticoagulant heparin analog, inhibits thrombin-induced PAR4 activation by interfering with thrombin exosite II, a mechanism of action distinct from other PAR4 inhibitors that target the receptor. The characteristics of SCH-28 provide a new strategy for targeting PAR4 with the potential for the treatment of arterial thrombosis. PMID: 30727756 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Lin YC, Ko YC, Hung SC, Lin YT, Lee JH, Tsai JY, Kung PH, Tsai MC, Chen YF, Wu CC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Promoters to Study Vascular Smooth Muscle.
Abstract Smooth muscle cells (SMCs) are a critical component of blood vessel walls that provide structural support, regulate vascular tone, and allow for vascular remodeling. These cells also exhibit a remarkable plasticity that contributes to vascular growth and repair but also to cardiovascular pathologies, including atherosclerosis, intimal hyperplasia and restenosis, aneurysm, and transplant vasculopathy. Mouse models have been an important tool for the study of SMC functions. The development of smooth muscle-expressing Cre-driver lines has allowed for exciting discoveries, including recent advances revealing ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2019 Category: Cardiology Authors: Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Correction to: Cystathionine γ-Lyase Modulates Flow-Dependent Vascular Remodeling.
Correction to: Cystathionine γ-Lyase Modulates Flow-Dependent Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):e82 Authors: PMID: 30673345 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2019 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Probing for Vulnerable Plaque in Patients With Diabetes Mellitus.
PMID: 30673346 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2019 Category: Cardiology Authors: Zaha VG, Joshi PH, McGuire DK Tags: Arterioscler Thromb Vasc Biol Source Type: research

Primum Non Nocere.
PMID: 30673347 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2019 Category: Cardiology Authors: Barton M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Wnt/ β-Catenin Inhibitor Dickkopf 1.
Wnt/β-Catenin Inhibitor Dickkopf 1. Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):121-123 Authors: Reinhold S, Blankesteijn WM PMID: 30673348 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2019 Category: Cardiology Authors: Reinhold S, Blankesteijn WM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Novel Features of Monocytes and Macrophages in Cardiovascular Biology and Disease.
PMID: 30673349 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2019 Category: Cardiology Authors: van der Vorst EPC, Weber C Tags: Arterioscler Thromb Vasc Biol Source Type: research

Amino Acids and Their Metabolism in Atherosclerosis.
Abstract As a leading cause of death worldwide, cardiovascular disease is a global health concern. The development and progression of atherosclerosis, which ultimately gives rise to cardiovascular disease, has been causally linked to hypercholesterolemia. Mechanistically, the interplay between lipids and the immune system during plaque progression significantly contributes to the chronic inflammation seen in the arterial wall during atherosclerosis. Localized inflammation and increased cell-to-cell interactions may influence polarization and proliferation of immune cells via changes in amino acid metabolism. Speci...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 17, 2019 Category: Cardiology Authors: Nitz K, Lacy M, Atzler D Tags: Arterioscler Thromb Vasc Biol Source Type: research

IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity.
Conclusions- Together, this study established a role of IL-33 in protecting mice from AAA formation by enhancing ST2-dependent aortic and systemic regulatory T-cell expansion and their immunosuppressive activities. PMID: 30651000 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 17, 2019 Category: Cardiology Authors: Li J, Xia N, Wen S, Li D, Lu Y, Gu M, Tang T, Jiao J, Lv B, Nie S, Liao M, Liao Y, Yang X, Hu Y, Shi GP, Cheng X Tags: Arterioscler Thromb Vasc Biol Source Type: research

PI3K γ (Phosphoinositide 3-Kinase γ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling.
Conclusions- PI3Kγ controls phenotypic modulation of VSMCs by regulating transcription factor CREB activation and YAP expression. Modulating PI3Kγ signaling on local vascular wall may represent a new therapeutic approach to treat proliferative vascular disease. PMID: 30651001 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 17, 2019 Category: Cardiology Authors: Yu Q, Li W, Jin R, Yu S, Xie D, Zheng X, Zhong W, Cheng X, Hu S, Li M, Zheng Q, Li G, Song Z Tags: Arterioscler Thromb Vasc Biol Source Type: research

Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Abstract Thoracic aortic aneurysms that progress to acute aortic dissections are often fatal. Thoracic aneurysms have been managed with treatment with β-adrenergic blocking agents (β-blockers) and routine surveillance imaging, followed by surgical repair of the aneurysm when the risk of dissection exceeds the risk for repair. Thus, there is a window to initiate therapies to slow aortic enlargement and delay or ideally negate the need for surgical repair of the aneurysm to prevent a dissection. Mouse models of Marfan syndrome-a monogenic disorder predisposing to thoracic aortic disease-have been used exte...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 17, 2019 Category: Cardiology Authors: Milewicz DM, Ramirez F Tags: Arterioscler Thromb Vasc Biol Source Type: research

FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Conclusions- We show that systemic inhibition of FURIN in mice decreases vascular remodeling and atherosclerosis. FURIN-mediated modulation of MMP2 activity may contribute to the atheroprotection observed in these mice. PMID: 30651003 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 17, 2019 Category: Cardiology Authors: Yakala GK, Cabrera-Fuentes HA, Crespo-Avilan GE, Rattanasopa C, Burlacu A, George BL, Anand K, Mayan DC, Corliano M, Hernández-Reséndiz S, Wu Z, Schwerk AMK, Tan ALJ, Trigueros-Motos L, Chevre R, Chua T, Kleemann R, Liehn EA, Hausenloy DJ, Ghosh S, Sing Tags: Arterioscler Thromb Vasc Biol Source Type: research

Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation.
Conclusions- This is the first report of a combination therapy with ponatinib and rapamycin promoting regression of VM. Mechanistically, the drug combination enhanced AKT inhibition compared with single drug treatment and reduced PLCγ and ERK activity. PMID: 30626204 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 10, 2019 Category: Cardiology Authors: Li X, Cai Y, Goines J, Pastura P, Brichta L, Lane A, Le Cras TD, Boscolo E Tags: Arterioscler Thromb Vasc Biol Source Type: research

TLR2 Promotes Vascular Smooth Muscle Cell Chondrogenic Differentiation and Consequent Calcification Via the Concerted Actions of Osteoprotegerin Suppression and IL-6-Mediated RANKL Induction.
Conclusions- We concluded that on ligand binding, TLR2 activates p38 and ERK1/2 signaling to selectively modulate the upregulation of IL-6-mediated RANKL and downregulation of OPG. These signaling pathways act in concert to induce chondrogenic transdifferentiation of VSMCs, which in turn leads to vascular calcification during the pathogenesis of atherosclerosis. PMID: 30626205 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 10, 2019 Category: Cardiology Authors: Lee GL, Yeh CC, Wu JY, Lin HC, Wang YF, Kuo YY, Hsieh YT, Hsu YJ, Kuo CC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.
Conclusions- Cigarette smoke enhances eEV generation with spermine enrichment at their outer surface and cytosol, which activates CaSR and subsequently causes smooth muscle cell constriction and proliferation, therefore, directly leading to the development of pulmonary hypertension. PMID: 30626206 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 10, 2019 Category: Cardiology Authors: Zhu L, Xiao R, Zhang X, Lang Y, Liu F, Yu Z, Zhang J, Su Y, Lu Y, Wang T, Luo S, Wang J, Liu ML, Dupuis J, Jing ZC, Li T, Xiong W, Hu Q Tags: Arterioscler Thromb Vasc Biol Source Type: research

Reversal of Aortic Enlargement Because of Increased Biomechanical Forces Requires AT1R (Angiotensin II Type 1 Receptor) Inhibition in Conjunction With AT2R (Angiotensin II Type 2 Receptor) Activation.
Conclusions- Our data indicate that when AT1R signaling is blocked, AT2R activation is a key modulator to prevent aortic dilation that occurs with TAC. These data suggest that angiotensin-converting enzyme inhibitor may not be as effective as losartan for slowing aneurysm growth because losartan requires intact AT2R signaling to prevent aortic enlargement. PMID: 30602301 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 3, 2019 Category: Cardiology Authors: Zhou Z, Peters AM, Wang S, Janda A, Chen J, Zhou P, Arthur E, Kwartler CS, Milewicz DM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the HIF-1 α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells.
Conclusions- These results suggest that miR-483 and UBE2C are novel flow-sensitive anti- and pro-calcific AV disease molecules, respectively, that regulate the HIF-1α pathway in AV. The miR-483 mimic and HIF-1α pathway inhibitors may serve as potential therapeutics of calcific AV disease. PMID: 30602302 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 3, 2019 Category: Cardiology Authors: Esmerats JF, Villa-Roel N, Kumar S, Gu L, Salim MT, Ohh M, Taylor WR, Nerem RM, Yoganathan AP, Jo H Tags: Arterioscler Thromb Vasc Biol Source Type: research

KLF11 (Kru üppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
Conclusions- Our data demonstrate that KLF11 is a novel transcriptional suppressor of F3 in vascular smooth muscle cells, constituting a potential molecular target for inhibition of arterial thrombosis. PMID: 30602303 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 3, 2019 Category: Cardiology Authors: Liang W, Fan Y, Lu H, Chang Z, Hu W, Sun J, Wang H, Zhu T, Wang J, Adili R, Garcia-Barrio MT, Holinstat M, Eitzman D, Zhang J, Chen YE Tags: Arterioscler Thromb Vasc Biol Source Type: research

What Would You Do With a £30 Million Research Grant?
What Would You Do With a £30 Million Research Grant? Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):e26-e28 Authors: Avkiran M, Samani NJ PMID: 30586331 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2018 Category: Cardiology Authors: Avkiran M, Samani NJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Authors: PMID: 30586332 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2018 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Reverse Cholesterol Transport and Atherosclerosis.
PMID: 30586333 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2018 Category: Cardiology Authors: Rohatgi A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Highlighting Residual Atherosclerotic Cardiovascular Disease Risk.
PMID: 30586334 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2018 Category: Cardiology Authors: Matsuura Y, Kanter JE, Bornfeldt KE Tags: Arterioscler Thromb Vasc Biol Source Type: research

Procoagulant Platelets Get Squeezed to Define the Boundaries of the Hemostatic Plug.
PMID: 30586335 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2018 Category: Cardiology Authors: Kholmukhamedov A, Jobe S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Editors and Editorial Board.
Authors: PMID: 30586336 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2018 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis.
Conclusions- These results reveal a regulatory role of megalin in the intrarenal renin-angiotensin homeostasis and atherogenesis, positing renal Ang II to be an important contributor to atherosclerosis that is mediated through AGT and megalin interactions. PMID: 30567480 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 20, 2018 Category: Cardiology Authors: Ye F, Wang Y, Wu C, Howatt DA, Wu CH, Balakrishnan A, Mullick AE, Graham MJ, Danser AHJ, Wang J, Daugherty A, Lu HS Tags: Arterioscler Thromb Vasc Biol Source Type: research

CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia.
Conclusions- CD36 promotes VSMC proliferation via upregulation of cyclin A expression that contributes to the development of neointimal hyperplasia, collagen deposition, and obstructive vascular diseases. PMID: 30567481 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 20, 2018 Category: Cardiology Authors: Yue H, Febbraio M, Klenotic PA, Kennedy DJ, Wu Y, Chen S, Gohara AF, Li O, Belcher A, Kuang B, McIntyre TM, Silverstein RL, Li W Tags: Arterioscler Thromb Vasc Biol Source Type: research

Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice.
Conclusions- Loss of 2 Akt isoforms in hematopoietic cells, preserving only a single Akt1 or Akt3 isoform, markedly compromises monocyte and macrophage viability and diminishes early atherosclerosis in Ldlr-/- mice. PMID: 30567482 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 20, 2018 Category: Cardiology Authors: Babaev VR, Ding L, Zhang Y, May JM, Ramsey SA, Vickers KC, Linton MF Tags: Arterioscler Thromb Vasc Biol Source Type: research

Perivascular Adipocytes Store Norepinephrine by Vesicular Transport.
Conclusions- This study supports a novel function of PVAT adipocytes in storing amines in a VMAT-dependent manner. It provides a foundation for future studies exploring the purpose and mechanisms of norepinephrine storage by PVAT in normal physiology and obesity-related hypertension. PMID: 30567483 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 20, 2018 Category: Cardiology Authors: Ahmad MF, Ferland D, Ayala-Lopez N, Contreras GA, Darios E, Thompson J, Ismail A, Thelen K, Moeser AJ, Burnett R, Anantharam A, Watts SW Tags: Arterioscler Thromb Vasc Biol Source Type: research

TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia.
Conclusions- Our novel findings imply cell type-specific functional role of TCF7L2 and provide critical insight into mechanisms underlying the pathogenesis of intimal hyperplasia. PMID: 30567484 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 20, 2018 Category: Cardiology Authors: Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Genome-Wide Expression Profiling Unveils Autoimmune Response Signatures in the Perivascular Adipose Tissue of Abdominal Aortic Aneurysm.
Conclusions- Our results support a possible function of PVAT in AAA pathogenesis and suggest that AAA is an immunologic disease with an underlying autoimmune component. Interfering with these disease-specific pathways would clarify their precise role in AAA pathogenesis. PMID: 30567485 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 20, 2018 Category: Cardiology Authors: Piacentini L, Pablo Werba J, Bono E, Saccu C, Tremoli E, Spirito R, Ivanoe Colombo G Tags: Arterioscler Thromb Vasc Biol Source Type: research

Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets.
Conclusions- Together, the results of our study reveal a novel role for Sin1 in platelet activation. Thus, Sin1 may be a valuable therapeutic target for interventions for ischemia-induced myocardial infarction deterioration. PMID: 30571167 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J Tags: Arterioscler Thromb Vasc Biol Source Type: research

Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies.
Conclusions- Taken together, correlation and permutation analyses support speciation of HDL. Functional studies of these novel subspecies and determination of their relation to diseases may provide new avenues to understand the HDL system of lipoproteins. PMID: 30571168 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Furtado JD, Yamamoto R, Melchior JT, Andraski AB, Gamez-Guerrero M, Mulcahy P, He Z, Cai T, Davidson WS, Sacks FM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Genetically Determined Platelet Count and Risk of Cardiovascular Disease.
Abstract Objective- Cardiovascular disease, including coronary artery disease (CAD) and ischemic stroke, is the leading cause of death worldwide. This Mendelian randomization study uses genetic variants as instruments to investigate whether there is a causal effect of genetically determined platelet count on CAD and ischemic stroke risk. Approach and Results- A genome-wide association study of 166 066 subjects was used to identify instruments and genetic association estimates for platelet count. Genetic association estimates for CAD and ischemic stroke were obtained from genome-wide association studies, inc...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Gill D, Monori G, Georgakis MK, Tzoulaki I, Laffan M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Carotid Flow Augmentation, Arterial Aging, and Cerebral White Matter Hyperintensities.
Abstract Objective- Aortic stiffness and pressure wave reflection are associated with age-related cerebral microvascular disease, but the underlying mechanism remains obscure. We hypothesized that cerebral (carotid) flow alterations potentially mediate these associations. Approach and Results- Doppler waveforms were recorded in 286 patients with hypertension to measure the carotid flow augmentation index (FAIx) as the late/early-systolic velocity amplitude ratio. Tonometric waveforms were recorded to estimate the aortic pressure AIx (PAIx), aortic compliance, and carotid-femoral and carotid-radial pulse wave veloc...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Hashimoto J, Westerhof BE, Ito S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Time-Dependent Hypotensive Effect of Aspirin in Mice.
Conclusions- The time-dependent hypotensive effect of aspirin in humans has been recapitulated in hypertensive mice. However, this does not seem to reflect a direct impact of aspirin on circadian clocks or on acetylation of platelet COX-1. PMID: 30571171 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Chen L, Yang G, Zhang J, Ren B, Tang S, Li X, FitzGerald GA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio).
Conclusions- Our study suggests a functional role for cilia in brain ECs, which is associated with the emergence and remodeling of the primary cranial vasculature. This cilia function is flow-independent, and cilia in ECs are required for cerebral-vascular stability. PMID: 30571172 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Eisa-Beygi S, Benslimane FM, El-Rass S, Prabhudesai S, Abdelrasoul MKA, Simpson PM, Yalcin HC, Burrows PE, Ramchandran R Tags: Arterioscler Thromb Vasc Biol Source Type: research

Brachial Artery Echogenicity and Grayscale Texture Changes in HIV-Infected Individuals Receiving Low-Dose Methotrexate.
Conclusions- Brachial artery GLDS-CON and entropy increased after 24 weeks of low-dose methotrexate, though the latter was not significantly different from placebo. Grayscale changes were associated with decreases in CD4+ T-cell and D-dimer concentrations and may indicate favorable arterial structure changes. PMID: 30571173 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Stein JH, Yeh E, Weber JM, Korcarz C, Ridker PM, Tawakol A, Hsue PY, Currier JS, Ribaudo H, Mitchell CKC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice.
Conclusions- Augmentation of intracellular adenosine levels through ADK knockout in myeloid cells protects ApoE-/- mice against atherosclerosis by reducing foam cell formation via the epigenetic regulation of cholesterol trafficking. ADK inhibition is a promising approach for the treatment of atherosclerotic diseases. PMID: 30571174 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Zhang M, Zeng X, Yang Q, Xu J, Liu Z, Zhou Y, Cao Y, Zhang X, An X, Xu Y, Huang L, Han Z, Wang T, Wu C, Fulton DJ, Weintraub NL, Hong M, Huo Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Association of Plasma Ceramides With Myocardial Perfusion in Patients With Coronary Artery Disease Undergoing Stress Myocardial Perfusion Scintigraphy.
Conclusions- Higher circulating levels of specific ceramides, both at baseline and after stress, were independently associated with lower poststress anteroapical wall perfusion in patients with suspected or established coronary artery disease referred for clinically indicated MPS. PMID: 30571175 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Mantovani A, Bonapace S, Lunardi G, Salgarello M, Dugo C, Gori S, Barbieri E, Verlato G, Laaksonen R, Byrne CD, Targher G Tags: Arterioscler Thromb Vasc Biol Source Type: research

Highlight on Endothelial Activation and Beyond.
PMID: 30571176 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Boulanger CM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders.
ang Y Abstract Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome is the best-characterized inflammasome. Recent evidence has indicated the importance of the NLRP3 inflammasome in the pathophysiology of cardiovascular disorders. To further understand the roles of the NLRP3 inflammasome in the cardiovascular system, we provide a comprehensive overview and discuss the remaining questions. First, a summary...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Wang Z, Hu W, Lu C, Ma Z, Jiang S, Gu C, Acuña-Castroviejo D, Yang Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Before the Pump.
PMID: 30571178 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 1, 2018 Category: Cardiology Authors: Norris DM, Santoro MM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Gene-Based Elevated Triglycerides and Type 2 Diabetes Mellitus Risk in the WGHS.
Abstract Objective- Higher triglyceride (TG) is a risk factor for incident type 2 diabetes mellitus (T2DM), but paradoxically, genetic susceptibility for higher TG has been associated with lower T2DM risk. There is also evidence that the genetic association may be modified by baseline TG. Whether such associations can be replicated and the interaction is selective for certain TG-rich lipoprotein particles remains to be explored. Approach and Results- Cox regression involving TG, TG-rich lipoprotein particles, and genetic determinants of TG was performed among 15 813 participants with baseline fasting status in the...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 29, 2018 Category: Cardiology Authors: Ahmad S, Mora S, Ridker PM, Hu FB, Chasman DI Tags: Arterioscler Thromb Vasc Biol Source Type: research

SR-BI (Scavenger Receptor Class B Type 1) Is Critical in Maintaining Normal T-Cell Development and Enhancing Thymic Regeneration.
Conclusions- This study demonstrates that SR-BI deficiency impaired T-cell development and delayed thymic regeneration by affecting progenitor thymic homing in mice, elucidating a previously unrecognized link between SR-BI and adaptive immunity. PMID: 30354229 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 26, 2018 Category: Cardiology Authors: Zheng Z, Ai J, Guo L, Ye X, Bondada S, Howatt D, Daugherty A, Li XA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature.
Conclusions- This study establishes mice with late endothelial cell-specific loss of Tspan12 as a model to study pathological consequences of BRB impairment in an otherwise intact vasculature. PMID: 30354230 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 26, 2018 Category: Cardiology Authors: Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ Tags: Arterioscler Thromb Vasc Biol Source Type: research