Carotid Atherosclerosis in Predicting Coronary Artery Disease: A Systematic Review and Meta-Analysis
Arterioscler Thromb Vasc Biol. 2021 Feb 25:ATVBAHA120315747. doi: 10.1161/ATVBAHA.120.315747. Online ahead of print.ABSTRACTOBJECTIVE: This meta-analysis aims to compare the relationship between phenotypic manifestation of coronary and carotid atherosclerosis using available imaging techniques. Approach and Results: We searched all electronic databases until October 2020 for studies which reported relationship between carotid and coronary atherosclerosis. The primary end point was correlation between carotid intima-media thickness (CIMT) and carotid plaque features (calcification and lipid-rich necrotic core) with coronary...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Ibadete Byty çi Rafik Shenouda Per Wester Michael Y Henein Source Type: research

Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated With Vascular Physiology
CONCLUSIONS: We created a cell atlas of human nondiseased cardiac arteries, and characterized the cellular compositions in different cardiac arteries. Our results could be used as a reference to identify vascular disease-associated cell populations and help investigate new therapeutic strategies for vascular diseases.PMID:33626908 | DOI:10.1161/ATVBAHA.120.315373 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Zhan Hu Wendao Liu Xiumeng Hua Xiao Chen Yuan Chang Yiqing Hu Zhenyu Xu Jiangping Song Source Type: research

Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes
CONCLUSIONS: These findings suggest that reelin inhibition may provide a novel therapeutic approach to counteract leukocyte or monocyte adhesion as well as extravasation and inhibit the progression of atherosclerosis. This strategy may also be relevant for other diseases that involve leukocyte or monocyte extravasation as a central pathological mechanism, such as multiple sclerosis or arthritis.PMID:33626909 | DOI:10.1161/ATVBAHA.121.316000 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Laurent Calvier Xunde Xian Richard Lee Anastasia Sacharidou Chieko Mineo Philip W Shaul Maria Z Kounnas Shirling Tsai Joachim Herz Source Type: research

Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19
CONCLUSIONS: We provide new associative data supporting that endotheliopathy and dysregulated immune responses are involved in respiratory and liver failure through microvascular damage in patients with severe COVID-19.PMID:33626910 | DOI:10.1161/ATVBAHA.120.315595 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Annabelle Dupont Antoine Rauch Senna Staessens Mouhamed Moussa Mickael Rosa Delphine Corseaux Emmanuelle Jeanpierre Julien Goutay Morgan Caplan Pauline Varlet Guillaume Lefevre Fanny Lassalle Anne Bauters Karine Faure Marc Lambert Alain Duhamel Julien Lab Source Type: research

Vascular Hypothesis of Alzheimer Disease: Topical Review of Mouse Models
Arterioscler Thromb Vasc Biol. 2021 Feb 25:ATVBAHA120311911. doi: 10.1161/ATVBAHA.120.311911. Online ahead of print.ABSTRACTAlzheimer disease (AD) is marked by profound neurodegeneration, neuroinflammation, and cognitive decline. Pathologically, AD is characterized by the accumulation of extracellular amyloid and intraneuronal tangles, consisting of hyperphosphorylated tau. To date, factors leading to disease onset and progression are still an important topic of investigation. Various epidemiological studies revealed cardiovascular disease as an important contributor to the development and progression of AD, leading to the...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Sanny Scheffer Dorien M A Hermkens Louise van der Weerd Helga E de Vries Mat J A P Daemen Source Type: research

Knockout of the < em > NONO < /em > Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury
CONCLUSIONS: NONO was not required for maintaining vascular integrity, but NONO knockout reversed the pathological processes mediated by increased proliferation, migration, and phenotypic switching of VSMCs. The mechanism of these effects involved an interaction of NONO and Erk signaling cascade. Thus, inhibition of NONO may provide a novel therapeutic strategy in cardiovascular disease associated with intimal thickening.PMID:33626912 | DOI:10.1161/ATVBAHA.119.313581 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Xingli Xu Xinghua Xu Yang Mao Lin Lu Jing Ma Tengfei Zheng Jie Zhang Meng Zhang Linlin Meng Lianyue Ma Jing Cheng Wenqiang Chen Hong Jiang Yun Zhang Cheng Zhang Source Type: research

Circulating Wnt Ligands Activate the Wnt Signaling Pathway in Mature Erythrocytes
CONCLUSIONS: These findings provide evidence for intracellular signaling activity in enucleated cells and signal transduction in the blood circulation and thus open new and exciting avenues for studying the function of signaling pathways in the bloodstream.PMID:33626913 | DOI:10.1161/ATVBAHA.120.315413 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Ronen Siman-Tov Natalie Zelikson Michal Caspi Yakir Levi Chava Perry Fayhaa Khair Hagit Stauber Josu é Sznitman Rina Rosin-Arbesfeld Source Type: research

Carotid Atherosclerosis in Predicting Coronary Artery Disease: A Systematic Review and Meta-Analysis
Arterioscler Thromb Vasc Biol. 2021 Feb 25:ATVBAHA120315747. doi: 10.1161/ATVBAHA.120.315747. Online ahead of print.ABSTRACTOBJECTIVE: This meta-analysis aims to compare the relationship between phenotypic manifestation of coronary and carotid atherosclerosis using available imaging techniques. Approach and Results: We searched all electronic databases until October 2020 for studies which reported relationship between carotid and coronary atherosclerosis. The primary end point was correlation between carotid intima-media thickness (CIMT) and carotid plaque features (calcification and lipid-rich necrotic core) with coronary...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Ibadete Byty çi Rafik Shenouda Per Wester Michael Y Henein Source Type: research

Single-Cell Transcriptomic Atlas of Different Human Cardiac Arteries Identifies Cell Types Associated With Vascular Physiology
CONCLUSIONS: We created a cell atlas of human nondiseased cardiac arteries, and characterized the cellular compositions in different cardiac arteries. Our results could be used as a reference to identify vascular disease-associated cell populations and help investigate new therapeutic strategies for vascular diseases.PMID:33626908 | DOI:10.1161/ATVBAHA.120.315373 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Zhan Hu Wendao Liu Xiumeng Hua Xiao Chen Yuan Chang Yiqing Hu Zhenyu Xu Jiangping Song Source Type: research

Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes
CONCLUSIONS: These findings suggest that reelin inhibition may provide a novel therapeutic approach to counteract leukocyte or monocyte adhesion as well as extravasation and inhibit the progression of atherosclerosis. This strategy may also be relevant for other diseases that involve leukocyte or monocyte extravasation as a central pathological mechanism, such as multiple sclerosis or arthritis.PMID:33626909 | DOI:10.1161/ATVBAHA.121.316000 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Laurent Calvier Xunde Xian Richard Lee Anastasia Sacharidou Chieko Mineo Philip W Shaul Maria Z Kounnas Shirling Tsai Joachim Herz Source Type: research

Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19
CONCLUSIONS: We provide new associative data supporting that endotheliopathy and dysregulated immune responses are involved in respiratory and liver failure through microvascular damage in patients with severe COVID-19.PMID:33626910 | DOI:10.1161/ATVBAHA.120.315595 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Annabelle Dupont Antoine Rauch Senna Staessens Mouhamed Moussa Mickael Rosa Delphine Corseaux Emmanuelle Jeanpierre Julien Goutay Morgan Caplan Pauline Varlet Guillaume Lefevre Fanny Lassalle Anne Bauters Karine Faure Marc Lambert Alain Duhamel Julien Lab Source Type: research

Vascular Hypothesis of Alzheimer Disease: Topical Review of Mouse Models
Arterioscler Thromb Vasc Biol. 2021 Feb 25:ATVBAHA120311911. doi: 10.1161/ATVBAHA.120.311911. Online ahead of print.ABSTRACTAlzheimer disease (AD) is marked by profound neurodegeneration, neuroinflammation, and cognitive decline. Pathologically, AD is characterized by the accumulation of extracellular amyloid and intraneuronal tangles, consisting of hyperphosphorylated tau. To date, factors leading to disease onset and progression are still an important topic of investigation. Various epidemiological studies revealed cardiovascular disease as an important contributor to the development and progression of AD, leading to the...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Sanny Scheffer Dorien M A Hermkens Louise van der Weerd Helga E de Vries Mat J A P Daemen Source Type: research

Knockout of the < em > NONO < /em > Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury
CONCLUSIONS: NONO was not required for maintaining vascular integrity, but NONO knockout reversed the pathological processes mediated by increased proliferation, migration, and phenotypic switching of VSMCs. The mechanism of these effects involved an interaction of NONO and Erk signaling cascade. Thus, inhibition of NONO may provide a novel therapeutic strategy in cardiovascular disease associated with intimal thickening.PMID:33626912 | DOI:10.1161/ATVBAHA.119.313581 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Xingli Xu Xinghua Xu Yang Mao Lin Lu Jing Ma Tengfei Zheng Jie Zhang Meng Zhang Linlin Meng Lianyue Ma Jing Cheng Wenqiang Chen Hong Jiang Yun Zhang Cheng Zhang Source Type: research

Circulating Wnt Ligands Activate the Wnt Signaling Pathway in Mature Erythrocytes
CONCLUSIONS: These findings provide evidence for intracellular signaling activity in enucleated cells and signal transduction in the blood circulation and thus open new and exciting avenues for studying the function of signaling pathways in the bloodstream.PMID:33626913 | DOI:10.1161/ATVBAHA.120.315413 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Ronen Siman-Tov Natalie Zelikson Michal Caspi Yakir Levi Chava Perry Fayhaa Khair Hagit Stauber Josu é Sznitman Rina Rosin-Arbesfeld Source Type: research

Arterial Gene Transfer With Lentivirus Vectors: The Jury Is Still Out
Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1156-1157. doi: 10.1161/ATVBAHA.120.315701. Epub 2021 Feb 24.NO ABSTRACTPMID:33625880 | DOI:10.1161/ATVBAHA.120.315701 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 24, 2021 Category: Cardiology Authors: Seppo Yla-Herttuala Source Type: research

Letter by Brambilla et al Regarding Article, "Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia"
Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):e183-e184. doi: 10.1161/ATVBAHA.120.315867. Epub 2021 Feb 24.NO ABSTRACTPMID:33625881 | DOI:10.1161/ATVBAHA.120.315867 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 24, 2021 Category: Cardiology Authors: Marta Brambilla Paola Canzano Elena Tremoli Marina Camera Source Type: research

Safeguarding the Vasculature: Redundant Transcriptional Machinery Ensures Endothelial Protection
Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1124-1126. doi: 10.1161/ATVBAHA.120.315868. Epub 2021 Feb 24.NO ABSTRACTPMID:33625882 | DOI:10.1161/ATVBAHA.120.315868 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 24, 2021 Category: Cardiology Authors: David R Sweet Mukesh K Jain Source Type: research

Benefit of Extracellular Vesicles at the Blood-Brain Barrier
Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1146-1148. doi: 10.1161/ATVBAHA.121.315833. Epub 2021 Feb 24.NO ABSTRACTPMID:33625883 | DOI:10.1161/ATVBAHA.121.315833 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 24, 2021 Category: Cardiology Authors: Sean M Davidson Source Type: research

Ceramide Scores Predict Cardiovascular Risk in the Community
CONCLUSIONS: Elevated ceramide score is a robust predictor of cardiovascular disease and MACE in the community. The risk conferred by the ceramide score has a dose-response behavior and is independent of conventional risk factors.PMID:33596665 | DOI:10.1161/ATVBAHA.120.315530 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: Vlad C Vasile Jeffrey W Meeusen Jose R Medina Inojosa Leslie J Donato Christopher G Scott Meredith S Hyun Manlio Vinciguerra Richard R Rodeheffer Francisco Lopez Jimenez Allan S Jaffe Source Type: research

Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA (Vascular Endothelial Growth Factor A)-Induced VE-Cadherin Internalization
CONCLUSIONS: We show that SDC4 is a downstream mediator of VEGFA-induced vascular endothelial cadherin internalization during pathological angiogenesis and a potential target for antiangiogenic therapies.PMID:33596666 | DOI:10.1161/ATVBAHA.121.315941 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: Giulia De Rossi Maria V ähätupa Enrico Cristante Samantha Arokiasamy Sidath E Liyanage Ulrike May Laura Pellinen Hannele Uusitalo-J ärvinen James W Bainbridge Tero A H Jarvinen James R Whiteford Source Type: research

Ceramide Scores Predict Cardiovascular Risk in the Community
CONCLUSIONS: Elevated ceramide score is a robust predictor of cardiovascular disease and MACE in the community. The risk conferred by the ceramide score has a dose-response behavior and is independent of conventional risk factors.PMID:33596665 | DOI:10.1161/ATVBAHA.120.315530 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: Vlad C Vasile Jeffrey W Meeusen Jose R Medina Inojosa Leslie J Donato Christopher G Scott Meredith S Hyun Manlio Vinciguerra Richard R Rodeheffer Francisco Lopez Jimenez Allan S Jaffe Source Type: research

Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA (Vascular Endothelial Growth Factor A)-Induced VE-Cadherin Internalization
CONCLUSIONS: We show that SDC4 is a downstream mediator of VEGFA-induced vascular endothelial cadherin internalization during pathological angiogenesis and a potential target for antiangiogenic therapies.PMID:33596666 | DOI:10.1161/ATVBAHA.121.315941 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: Giulia De Rossi Maria V ähätupa Enrico Cristante Samantha Arokiasamy Sidath E Liyanage Ulrike May Laura Pellinen Hannele Uusitalo-J ärvinen James W Bainbridge Tero A H Jarvinen James R Whiteford Source Type: research

Ceramide Scores Predict Cardiovascular Risk in the Community.
CONCLUSIONS: Elevated ceramide score is a robust predictor of cardiovascular disease and MACE in the community. The risk conferred by the ceramide score has a dose-response behavior and is independent of conventional risk factors. PMID: 33596665 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: Vasile VC, Meeusen JW, Medina Inojosa JR, Donato LJ, Scott CG, Hyun MS, Vinciguerra M, Rodeheffer RR, Lopez Jimenez F, Jaffe AS Tags: Arterioscler Thromb Vasc Biol Source Type: research

Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA (Vascular Endothelial Growth Factor A)-Induced VE-Cadherin Internalization.
CONCLUSIONS: We show that SDC4 is a downstream mediator of VEGFA-induced vascular endothelial cadherin internalization during pathological angiogenesis and a potential target for antiangiogenic therapies. PMID: 33596666 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 18, 2021 Category: Cardiology Authors: De Rossi G, Vähätupa M, Cristante E, Arokiasamy S, Liyanage SE, May U, Pellinen L, Uusitalo-Järvinen H, Bainbridge JW, Jarvinen TAH, Whiteford JR Tags: Arterioscler Thromb Vasc Biol Source Type: research

Impact of Cardiovascular Hemodynamics on Cognitive Aging.
Abstract It is well known that cardiovascular disease and related vascular risk factors are associated with cognitive decline and worse brain health outcomes among aging adults. Recently, subtle age-related changes in cardiac hemodynamics have been proposed as an emerging risk factor for abnormal brain aging, even in the absence of cardiovascular disease. Changes in cardiac function, vital for determining the total amount of blood available for perfusing the body, and arterial stiffness, important for regulating blood flow delivery, have been associated with compromised brain structure and function among older adu...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Moore EE, Jefferson AL Tags: Arterioscler Thromb Vasc Biol Source Type: research

Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice.
CONCLUSIONS: Cardiac small vessel disease is a key mechanism of heart failure with preserved ejection fraction pathophysiology that can be targeted to prevent the occurrence of diastolic dysfunction, by using both mast cell stabilizers and antihistaminic drugs. PMID: 33567863 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Guimbal S, Cornuault L, Rouault P, Hollier PL, Chapouly C, Bats ML, Imbault J, Gadeau AP, Couffinhal T, Renault MA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cancer Therapy-Associated Thrombosis.
Abstract Patients with cancer have an increased risk of both arterial and venous thrombotic events compared with the general population. Both the site and stage of cancer are known to contribute to the increased risk of thrombotic events. In addition, several treatment-related factors enhance the risk of thrombosis, including hospitalization, surgery, central venous catheters, radiation, and anticancer agents. Chemotherapy serves as a mainstay treatment for a broad range of malignancies. Chemotherapeutic agents typically exert antineoplastic effects through either direct cytotoxicity or inhibition of cellular proc...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Grover SP, Hisada YM, Kasthuri RS, Reeves BN, Mackman N Tags: Arterioscler Thromb Vasc Biol Source Type: research

Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm.
CONCLUSIONS: The present results suggest that TP signaling exerts prolymphangiogenic activity by acting on macrophages and T cells accumulated during inflammation and that TP signaling represents a novel target for controlling lymphangiogenesis. PMID: 33567865 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Matsuda H, Ito Y, Hosono K, Tsuru S, Inoue T, Nakamoto S, Kurashige C, Hirashma M, Narumiya S, Okamoto H, Majima M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Hepatic SRB1 (Scavenger Receptor Class B Type 1) Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice.
CONCLUSIONS: Hepatic SRB1 knockdown in a mouse model with an intact ApoE (apolipoprotein E)-LDLR (low density lipoprotein receptor) clearance pathway, relevant to human lipoprotein metabolism, reduced atherosclerosis and improved the beneficial effect of brown fat activation on atherosclerosis development, explained by pleiotropic effects of hepatic SRB1 knockdown on lipolytic processing and hepatic uptake of VLDL. Brown fat activation could thus be an effective strategy to treat cardiovascular disease also in subjects with impaired SRB1 function. PMID: 33567866 [PubMed - as supplied by publisher] (Source: Arterioscle...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Zhou E, Li Z, Nakashima H, Liu C, Ying Z, Foks AC, Berbée JFP, van Dijk KW, Rensen PCN, Wang Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of αIIbβ3 and GPIb via Microparticle Shedding Decreasing Platelet Aggregability.
CONCLUSIONS: Our data clearly indicate that accumulation of shear stress, consistent with supraphysiologic conditions characterizing device-supported circulation (1) induces adequate platelet degranulation, yet (2) causes downregulation of primary platelet adhesion receptors via ejection of receptor-enriched platelet-derived microparticles, thus mechanistically limiting platelet activation and the aggregatory response. PMID: 33567867 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Roka-Moiia Y, Miller-Gutierrez S, Palomares DE, Italiano JE, Sheriff J, Bluestein D, Slepian MJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.
CONCLUSIONS: This study identifies evolutionarily conserved gene signatures and signaling pathways in a stage-specific manner that successfully distinguishes diabetes- and non-diabetes-associated atherosclerosis. These findings establish new molecular insights and therapeutic opportunities to address accelerated atherosclerotic lesion formation in diabetes. PMID: 33567868 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Haemmig S, Hashemi Gheinani A, Zaromytidou M, Siasos G, Coskun AU, Cormier MA, Gross DA, Wara AKMK, Antoniadis A, Sun X, Sukhova GK, Welt F, Andreou I, Whatling C, Gan LM, Wikström J, Edelman ER, Libby P, Stone PH, Feinberg MW Tags: Arterioscler Thromb Vasc Biol Source Type: research

Anticytomegalovirus CD4+ T Cells Are Associated With Subclinical Atherosclerosis in Persons With HIV.
CONCLUSIONS: HIV-positive persons with carotid atheroma have a higher proportion of circulating CD4+ T-cells expressing the C~G~C surface marker combination associated with cytotoxic function. These cells can be cytomegalovirus-specific and are also present in the aorta. PMID: 33567869 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Wanjalla CN, Mashayekhi M, Bailin S, Gabriel CL, Meenderink LM, Temu T, Fuller DT, Guo L, Kawai K, Virmani R, Jenkins C, Abana CO, Warren CM, Gangula R, Smith R, Madhur MS, Finn AV, Gelbard AH, Su YR, Tyska MJ, Kalams SA, Harrison DG, Mallal SA, Absi TS, Tags: Arterioscler Thromb Vasc Biol Source Type: research

Obstructive Sleep Apnea, Sleep Duration, and Associated Mediators With Carotid Intima-Media Thickness: The ELSA-Brasil Study.
Abstract OBJECTIVE: To elucidate the independent associations of obstructive sleep apnea (OSA) and sleep duration (SD) as well as the potential inflammatory and metabolic mediators on carotid intima-media thickness (CIMT) in a large cohort of adults. Approach and Results: Consecutive participants from the ELSA-Brasil performed a clinical evaluation, sleep study, 1-week actigraphy for defining SD and CIMT using standard techniques. Gamma regression models were used to explore the association between OSA and SD with CIMT. Mediation analysis was performed using the mediation R package. A total of 2009 participants we...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Souza SP, Santos RB, Santos IS, Parise BK, Giatti S, Aielo AN, Cunha LF, Silva WA, Bortolotto LA, Lorenzi-Filho G, Lotufo PA, Bensenor IM, Drager LF Tags: Arterioscler Thromb Vasc Biol Source Type: research

Systematic Review and Meta-Analysis of Interventions to Slow Progression of Abdominal Aortic Aneurysm in Mouse Models.
CONCLUSIONS: There is low-quality evidence that a range of drugs are effective in limiting AAA progression when administered early after AAA induction in mouse models. Some of these drugs, such as antiplatelet and renin-angiotensin system inhibitors, have been reported to be ineffective in clinical trials. PMID: 33567871 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Phie J, Thanigaimani S, Golledge J Tags: Arterioscler Thromb Vasc Biol Source Type: research

New Insight Into Metformin-Induced Cholesterol-Lowering Effect Crosstalk Between Glucose and Cholesterol Homeostasis via ChREBP (Carbohydrate-Responsive Element-Binding Protein)-Mediated PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Regulation.
CONCLUSIONS: Collectively, we revealed a new mechanism of action of metformin in cholesterol-lowering and identified a novel crosstalk signal between glucose and cholesterol homeostasis via ChREBP-mediated PCSK9 regulation. PMID: 33535788 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2021 Category: Cardiology Authors: Hu D, Guo Y, Wu R, Shao T, Long J, Yu B, Wang H, Luo Y, Lu H, Zhang J, Chen YE, Peng D Tags: Arterioscler Thromb Vasc Biol Source Type: research

Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography.
CONCLUSIONS: In mice, CTD imaging exhibits high sensitivity for detecting aortic wall degeneration and inflammation before vessel enlargement becomes evident in CTA. PMID: 33535789 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2021 Category: Cardiology Authors: Ghaghada KB, Ren P, Devkota L, Starosolski Z, Zhang C, Vela D, Stupin IV, Tanifum EA, Annapragada AV, Shen YH, LeMaire SA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Beneficial Effect of Statins in COVID-19-Related Outcomes: A National Population-Based Cohort Study.
CONCLUSIONS: The use of statins correlates significantly with lower mortality in patients with COVID-19, consistent with the findings in patients with pneumonia. PMID: 33535790 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2021 Category: Cardiology Authors: Lee HY, Ahn J, Park J, Kyung Kang C, Won SH, Wook Kim D, Park JH, Chung KH, Joh JS, Bang J, Hee Kang C, Bum Pyun W, Oh MD Tags: Arterioscler Thromb Vasc Biol Source Type: research

Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus.
CONCLUSIONS: Serum metabolites are promising biomarkers to uncover and predict multimetabolic phenotypes of subclinical atherosclerosis in SLE. PMID: 33535791 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 1, 2021 Category: Cardiology Authors: Coelewij L, Waddington KE, Robinson GA, Chocano E, McDonnell T, Farinha F, Peng J, Donnes P, Smith E, Croca S, Bakshi J, Griffin M, Nicolaides A, Rahman A, Jury EC, Pineda-Torra I Tags: Arterioscler Thromb Vasc Biol Source Type: research

Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
CONCLUSIONS: ChGn-2 alteration on macrophages conceivably influences LDL accumulation and subsequently accelerates plaque formation. These results collectively suggest that ChGn-2 is a novel therapeutic target amenable to clinical translation in the future. PMID: 33504177 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 28, 2021 Category: Cardiology Authors: Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata KI, Emoto N Tags: Arterioscler Thromb Vasc Biol Source Type: research

Conventional and Novel Lipid Measures and Risk of Peripheral Artery Disease.
CONCLUSIONS: Triglyceride-related and HDL-related lipids were independently associated with incident PAD, which has implications on preventive strategies for PAD. However, none of the novel lipid measures outperformed conventional ones. PMID: 33504178 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 28, 2021 Category: Cardiology Authors: Kou M, Ding N, Ballew SH, Salameh MJ, Martin SS, Selvin E, Heiss G, Ballantyne CM, Matsushita K, Hoogeveen RC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Telomerase As a Therapeutic Target in Cardiovascular Disease.
los I Abstract Shortened telomeres have been linked to numerous chronic diseases, most importantly coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function mutations and deletions in telomerase both accelerate telomere shortening but do not necessarily lead to a clinical phenotype associated with atherosclerosis, questioning the causal role of telomere length in cardiac pathology. The differential extranuclear functions of the 2 main components of telomerase, telomerase reverse transcriptase and telomerase RNA component, offer important clues about the complex relationship betwee...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 28, 2021 Category: Cardiology Authors: Hoffmann J, Richardson G, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I Tags: Arterioscler Thromb Vasc Biol Source Type: research

Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease.
We examined thoracic PVAT samples in 34 subjects (body mass index 32±6 kg/m2, age 59±11 years) undergoing valvular, aortic, or coronary artery bypass graft surgeries and performed transcriptomic characterization using whole-genome expression profiling and quantitative polymerase chain reaction analyses. We identified a highly inflamed region of PVAT surrounding the human aortic root in close proximity to coronary takeoff and adjoining epicardial fat. In subjects undergoing coronary artery bypass graft, we found 300 genes significantly upregulated (false discovery rate Q
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 28, 2021 Category: Cardiology Authors: Mazzotta C, Basu S, Gower AC, Karki S, Farb MG, Sroczynski E, Zizza E, Sarhan A, Pande AN, Walsh K, Dobrilovic N, Gokce N Tags: Arterioscler Thromb Vasc Biol Source Type: research

COMP (Cartilage Oligomeric Matrix Protein) Neoepitope: A Novel Biomarker to Identify Symptomatic Carotid Stenosis.
CONCLUSIONS: Degradation of COMP may be associated with atherosclerosis progression and generation of a specific COMP fragment-COMPneo. This may represent a novel biomarker that together with COMPtotal and other risk-markers could be used to identify symptomatic carotid stenosis. PMID: 33472398 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Sandstedt J, Vargmar K, Björkman K, Ruetschi U, Bergström G, Hultén LM, Skiöldebrand E Tags: Arterioscler Thromb Vasc Biol Source Type: research

Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation.
CONCLUSIONS: These results suggest that NCs derange resolution by limiting specialized proresolving mediator (eg, RvD1) synthesis and through an impairment in the efferocytic repertoire of macrophages. Moreover, these findings provide a molecular mechanism for RvD1 in directing proresolving metabolic programs in macrophages and further suggests RvD1 as a potential therapeutic strategy to limit NCs in tissues. PMID: 33472399 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Hosseini Z, Marinello M, Decker C, Sansbury BE, Sadhu S, Gerlach BD, Bossardi Ramos R, Adam AP, Spite M, Fredman G Tags: Arterioscler Thromb Vasc Biol Source Type: research

Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice.
Abstract OBJECTIVE: Statins lower cardiovascular event risk, yet, they paradoxically increase coronary artery calcification, a marker consistently associated with increased cardiovascular risks. As calcium deposits influence rupture risk due to stress from compliance mismatch at their surfaces, we hypothesized that statins may lower cardiovascular risk by altering the microarchitecture of calcium deposits. Thus, using mice with preexisting vascular calcification, we tested whether pravastatin reduces the mineral surface area of calcium deposits. Approach and Results: Aged Apoe-/- mice were treated with pravastatin...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Clinical Trial in a Dish: Using Patient-Derived Induced Pluripotent Stem Cells to Identify Risks of Drug-Induced Cardiotoxicity.
Abstract Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market being labeled with warnings on cardiovascular adverse effects. Treatments are often prematurely halted when cardiotoxicity is observed, which limits their therapeutic potential. Moreover, cardiotoxicity is a major reason for abandonment during drug development, reducing available treatment options for diseases and creating a significant financial burden and disincentive for drug developers. Thus, it is important to minimize the cardiotoxic effects of medications that are in use or in development. To this end, identi...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Lam CK, Wu JC Tags: Arterioscler Thromb Vasc Biol Source Type: research

GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region.
CONCLUSIONS: Based on the above findings, we conclude that the higher affinity of dimeric GPVI over the monomer for fibrinogen interaction is achieved by avidity. The αC-region of fibrinogen appears essential for GPVI binding. We propose that fibrin polymerization into fibers during coagulation will cluster GPVI through its αC-region, leading to downstream signaling, further activation of platelets, and potentially stimulating clot growth. PMID: 33472402 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Xu RG, Gauer JS, Baker SR, Slater A, Martin EM, McPherson HR, Duval C, Manfield IW, Bonna AM, Watson S, Ariëns RAS Tags: Arterioscler Thromb Vasc Biol Source Type: research

Single-Cell RNA Sequencing Reveals Heterogeneity of Vascular Cells in Early Stage Murine Abdominal Aortic Aneurysm.
CONCLUSIONS: Together, these data provide high-resolution insight into the complexity and heterogeneity of mouse AAA and indicate that populations within major cell types such as smooth muscle cells, fibroblasts, and macrophages may contribute differently to AAA pathogenesis. PMID: 33472403 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Yang H, Zhou T, Stranz A, DeRoo E, Liu B Tags: Arterioscler Thromb Vasc Biol Source Type: research

Identification of Celastrol As a Novel Therapeutic Agent for Pulmonary Arterial Hypertension and Right Ventricular Failure Through Suppression of Bsg (Basigin)/CyPA (Cyclophilin A).
CONCLUSIONS: These results indicate that elevated Bsg in pressure-overloaded RV exacerbates RV dysfunction and that celastrol ameliorates RV dysfunction in PH model animals by suppressing Bsg and its ligand CyPA. Thus, celastrol can be a novel drug for PH and RV failure that targets Bsg and CyPA. PMID: 33472404 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Kurosawa R, Satoh K, Nakata T, Shindo T, Kikuchi N, Satoh T, Siddique MAH, Omura J, Sunamura S, Nogi M, Takeuchi Y, Miyata S, Shimokawa H Tags: Arterioscler Thromb Vasc Biol Source Type: research

Inhibition of T-Cells by CsA (Cyclosporine A) Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Maturation.
CONCLUSIONS: T-cells regulate macrophage accumulation in the maturing venous wall to control adaptive remodeling. Regulation of T-cells during AVF maturation may be a strategy that can improve AVF maturation. PMID: 33472405 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Matsubara Y, Kiwan G, Liu J, Gonzalez L, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Dardik A Tags: Arterioscler Thromb Vasc Biol Source Type: research