HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure.
CONCLUSIONS: Our findings indicate that HuR regulates vascular smooth muscle contraction and maintains blood pressure by modulating RGS expression. PMID: 32075416 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Liu S, Jiang X, Lu H, Xing M, Qiao Y, Zhang C, Zhang W Tags: Arterioscler Thromb Vasc Biol Source Type: research

Etv2- and Fli1-Induced Vascular Progenitor Cells Enhance Functional Recovery in Ischemic Vascular Disease Model.
CONCLUSIONS: We demonstrate that ischemic disease curable iVPCs, which have self-renewal and bipotency, can be generated from mouse fibroblasts by enforced ETS family transcription factors, Etv2 and Fli1 expression. Our simple strategy opens insights into stem cell-based ischemic disease therapy. PMID: 32075417 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Park SY, Lee H, Kwon YW, Park MR, Kim JH, Kim JB Tags: Arterioscler Thromb Vasc Biol Source Type: research

Microvascular Disease Increases Amputation in Patients With Peripheral Artery Disease.
Abstract It is estimated that>2 million patients are living with an amputation in the United States. Peripheral artery disease (PAD) and diabetes mellitus account for the majority of nontraumatic amputations. The standard measurement to diagnose PAD is the ankle-brachial index, which integrates all occlusive disease in the limb to create a summary value of limb artery occlusive disease. Despite its accuracy, ankle-brachial index fails to well predict limb outcomes. There is an emerging body of literature that implicates microvascular disease (MVD; ie, retinopathy, nephropathy, neuropathy) as a systemic phenomen...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Behroozian A, Beckman JA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Mechanisms of Arterial Stiffening: From Mechanotransduction to Epigenetics.
Abstract Arterial stiffness is a major independent risk factor for cardiovascular complications causing isolated systolic hypertension and increased pulse pressure in the microvasculature of target organs. Stiffening of the arterial wall is determined by common mechanisms including reduced elastin/collagen ratio, production of elastin cross-linking, reactive oxygen species-induced inflammation, calcification, vascular smooth muscle cell stiffness, and endothelial dysfunction. This brief review will discuss current biological mechanisms by which other cardiovascular risk factors (eg. aging, hypertension, diabetes m...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Lacolley P, Regnault V, Laurent S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Recipients of the 2020 Early Career Investigator Awards.
PMID: 32075420 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Daugherty A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation.
CONCLUSIONS: The findings imply that endothelial FSTL1 is critical for the homeostasis of vascular walls, and its insufficiency may favor cardiovascular fibrosis leading to heart failure. PMID: 32078339 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 13, 2020 Category: Cardiology Authors: Jiang H, Zhang L, Liu X, Sun W, Kato K, Chen C, Li X, Li T, Sun Z, Han W, Zhang F, Xiao Q, Yang Z, Hu J, Qin Z, Adams RH, Gao X, He Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Warfarin Accelerates Medial Arterial Calcification in Humans.
CONCLUSIONS: Warfarin significantly accelerates medial arterial calcification in humans. This effect is markedly augmented in end-stage renal disease. PMID: 32078340 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 13, 2020 Category: Cardiology Authors: Alappan HR, Kaur G, Manzoor S, Navarrete J, O'Neill WC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Novel Long Noncoding RNA, Macrophage Inflammation-Suppressing Transcript (MIST), Regulates Macrophage Activation During Obesity.
CONCLUSIONS: Mist is a novel protective long noncoding RNA, and its loss during obesity contributes to metabolic dysfunction and proinflammatory phenotype of macrophages via epigenetic mechanisms. PMID: 32078363 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 13, 2020 Category: Cardiology Authors: Stapleton K, Das S, Reddy MA, Leung A, Amaram V, Lanting L, Chen Z, Zhang L, Palanivel R, Deiuliis JA, Natarajan R Tags: Arterioscler Thromb Vasc Biol Source Type: research

Atherosclerosis Immunoimaging by Positron Emission Tomography.
r WJM Abstract The immune system's role in atherosclerosis has long been an important research topic and is increasingly investigated for therapeutic and diagnostic purposes. Therefore, noninvasive imaging of hematopoietic organs and immune cells will undoubtedly improve atherosclerosis phenotyping and serve as a monitoring method for immunotherapeutic treatments. Among the available imaging techniques, positron emission tomography's unique features make it an ideal tool to quantitatively image the immune response in the context of atherosclerosis and afford reliable readouts to guide medical interventions in card...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Pérez-Medina C, Fayad ZA, Mulder WJM Tags: Arterioscler Thromb Vasc Biol Source Type: research

2019 ATVB Plenary Lecture: IL (Interleukin)-2 Therapy in Cardiovascular Disease: The Potential to Regulate Innate and Adaptive Immunity.
Abstract Regulatory T cells and type-2 innate lymphoid cells represent 2 subsets of immune cells, which have been shown in preclinical models to be important in atherosclerosis and myocardial repair. Regulatory T cells play a crucial role in immune homeostasis and tolerance via their interactions with effector T cells, dendritic cells, and monocytes/macrophages. They also utilize and secrete inhibitory cytokines, including interleukin 10 and transforming growth factor β, to regulate or suppress pathogenic immune responses. Type-2 innate lymphoid cells have an important role in type-2 immune responses and tiss...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Zhao TX, Newland SA, Mallat Z Tags: Arterioscler Thromb Vasc Biol Source Type: research

VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly.
urt-Dupuy E Abstract OBJECTIVE: To clarify the association between PCSK9 (proprotein convertase subtilisin/kexin type 9) and Lp(a) (Lipoprotein [a]), we studied Lp(a) kinetics in patients with loss-of-function and gain-of-function PCSK9 mutations and in patients in whom extended-release niacin reduced Lp(a) and PCSK9 concentrations. Approach and Results: Six healthy controls, 9 heterozygous patients with familial hypercholesterolemia (5 with low-density lipoprotein receptor [LDLR] mutations and 4 with PCSK9 gain-of-function mutations) and 3 patients with heterozygous dominant-negative PCSK9 loss-of-function mutati...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Croyal M, Blanchard V, Ouguerram K, Chétiveaux M, Cabioch L, Moyon T, Billon-Crossouard S, Aguesse A, Bernardeau K, Le May C, Flet L, Lambert G, Hadjadj S, Cariou B, Krempf M, Nobécourt-Dupuy E Tags: Arterioscler Thromb Vasc Biol Source Type: research

Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting.
CONCLUSIONS: Our data demonstrate that Cx37 expression is differentially regulated by shear stress and SMAD1/5 signaling, and that reduced Cx37 expression is permissive for capillary enlargement into shunts. PMID: 32078368 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Peacock HM, Tabibian A, Criem N, Caolo V, Hamard L, Deryckere A, Haefliger JA, Kwak BR, Zwijsen A, Jones EAV Tags: Arterioscler Thromb Vasc Biol Source Type: research

Total White Blood Cell Count Mediated the Association Between Increased Arterial Stiffness and Risk of Type 2 Diabetes Mellitus in Chinese Adults.
Abstract OBJECTIVE: Type 2 diabetes mellitus (T2DM) is known to be related to increased arterial stiffness. However, little is known about the risk of T2DM due to accelerated arterial stiffness and the underlying mechanism involved. We aimed to examine arterial stiffness, as determined by branchial-ankle pulse wave velocity (baPWV), in relation to diabetes mellitus among a community-based population and whether the association was mediated by white blood cell (WBC) counts. Approach and results: A total of 1036 Chinese adults aged 64.3 years with complete data were qualified in the present study. The dose-response ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Liu Y, Lai X, Guo W, Ma L, Li W, Fang Q, Yang H, Cai Y, Liu M, Zhang X, Yang L Tags: Arterioscler Thromb Vasc Biol Source Type: research

Correction to: Shear Stress and VE-Cadherin: The Molecular Mechanism of Vascular Fusion.
Authors: PMID: 31967902 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Response by Fotakis et al to Letter Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques".
Response by Fotakis et al to Letter Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):e33-e34 Authors: Fotakis P, Kothari V, Bornfeldt KE, Tall AR PMID: 31967903 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: Fotakis P, Kothari V, Bornfeldt KE, Tall AR Tags: Arterioscler Thromb Vasc Biol Source Type: research

Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques".
Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):e31-e32 Authors: van der Vorst EPC, Biessen EAL, Donners MMPC PMID: 31967904 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: van der Vorst EPC, Biessen EAL, Donners MMPC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Metabolic Regulators of Vascular Inflammation.
PMID: 31967905 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: Fairman G, Robichaud S, Ouimet M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.
PMID: 31967906 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: Guo L, Cornelissen A, Sakamoto A, Finn AV Tags: Arterioscler Thromb Vasc Biol Source Type: research

Disruption of PLTP (Phospholipid Transfer Protein)-Mediated HDL (High-Density Lipoprotein) Maturation Reduces SR-BI (Scavenger Receptor BI) Deficiency-Driven Atherosclerosis Susceptibility Despite Unexpected Metabolic Complications.
CONCLUSIONS: We have shown that disruption of PLTP-mediated HDL maturation reduces SR-BI deficiency-driven atherosclerosis susceptibility in mice despite the induction of proatherogenic metabolic complications in the double knockout mice. PMID: 31941380 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 16, 2020 Category: Cardiology Authors: Hoekstra M, van der Sluis RJ, Hildebrand RB, Lammers B, Zhao Y, Praticò D, van Berkel TJC, Rensen PCN, Kooijman S, Jauhiainen M, van Eck M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Homocysteine Level Predicts Response to Dual Antiplatelet in Women With Minor Stroke or Transient Ischemic Attack: Subanalysis of the CHANCE Trial.
CONCLUSIONS: Homocysteine could be a potential biomarker to discriminate the effects of dual and single antiplatelet therapy in female patients with minor ischemic stroke or high-risk transient ischemic attack. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589. PMID: 31941381 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 16, 2020 Category: Cardiology Authors: Li J, Wang Y, Li H, Zuo Z, Lin J, Wang A, Zhao X, Liu L, Wang Y, CHANCE Investigators* Tags: Arterioscler Thromb Vasc Biol Source Type: research

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF- κB (Nuclear Factor κB) Signals.
CONCLUSIONS: This study for the first time demonstrates that TMAO promotes vascular calcification through activation of NLRP3 inflammasome and NF-κB signals, suggesting the potential link between gut microbial metabolism and vascular calcification. Reducing the levels of TMAO could become a potential treatment strategy for vascular calcification in chronic kidney disease. PMID: 31941382 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 16, 2020 Category: Cardiology Authors: Zhang X, Li Y, Yang P, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J, Chen M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.
CONCLUSIONS: Our findings demonstrate that WPS exposure directly modulates hemostasis and increases the risk of thrombosis and that this is mediated, in part, via a state of platelet hyperactivity. The negative health impact of WPS/hookah, therefore, should not be underestimated. Moreover, this study should also help in raising public awareness of the toxic effects of waterpipe/hookah.Visual Overview: An online visual overview is available for this article. PMID: 31941383 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 16, 2020 Category: Cardiology Authors: Alarabi AB, Karim ZA, Ramirez JEM, Hernandez KR, Lozano PA, Rivera JO, Alshbool FZ, Khasawneh FT Tags: Arterioscler Thromb Vasc Biol Source Type: research

High Brown Fat Activity Correlates With Cardiovascular Risk Factor Levels Cross-Sectionally and Subclinical Atherosclerosis at 5-Year Follow-Up.
CONCLUSIONS: Cold-induced BAT activity at baseline seems to correlate with lower levels of conventional cardiovascular risk factors at baseline and with lower carotid intima-media thickness and higher carotid elasticity at 5-year follow-up. PMID: 31941384 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 16, 2020 Category: Cardiology Authors: Raiko J, Orava J, Savisto N, Virtanen KA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Effects of Post-Translational Modifications of Fibrinogen on Clot Formation, Clot Structure, and Fibrinolysis: A Systematic Review.
CONCLUSIONS: Overall, post-translational modifications do affect clot formation and characteristics. More studies need to be performed to reveal the effects of all post-translational modifications and the effects on thrombotic diseases. Expanding the knowledge about modifications of fibrinogen can ultimately contribute to optimizing treatments for thrombotic diseases. PMID: 31914791 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 9, 2020 Category: Cardiology Authors: de Vries JJ, Snoek CJM, Rijken DC, de Maat MPM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Native, Intact Glucagon-Like Peptide-1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions.
CONCLUSIONS: Native, intact GLP-1 is a natural suppressor of thrombus growth under physiological flow conditions, with DPP-4 inhibition and increased intact GLP-1 suppressing platelet aggregation under flow without a main relevance of GLP-1-receptor on platelets. PMID: 31893947 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 2, 2020 Category: Cardiology Authors: Sternkopf M, Nagy M, Baaten CCFMJ, Kuijpers MJE, Tullemans BME, Wirth J, Theelen W, Mastenbroek TG, Lehrke M, Winnerling B, Baerts L, Marx N, De Meester I, Döring Y, Cosemans JMEM, Daiber A, Steven S, Jankowski J, Heemskerk JWM, Noels H Tags: Arterioscler Thromb Vasc Biol Source Type: research

NF κB (Nuclear Factor κ-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type-Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve.
CONCLUSIONS: Our results identify NFκB signaling as an essential molecular regulator for both valve endothelial and interstitial participation in CAVD pathogenesis. Direct demonstration of valve endothelial cell endothelial to mesenchymal transformation transmigration in vivo during CAVD highlights a new cellular population for further investigation in CAVD morbidity. The efficacy of valve-specific NFκB modulation in inhibiting hypercholesterolemic CAVD suggests potential benefits of multicell type integrated investigation for biological therapeutic development and evaluation for CAVD. PMID: 31893948 [PubM...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 2, 2020 Category: Cardiology Authors: Gee T, Farrar E, Wang Y, Wu B, Hsu K, Zhou B, Butcher J Tags: Arterioscler Thromb Vasc Biol Source Type: research

Noncoding RNAs in Critical Limb Ischemia.
rg MW Abstract Peripheral artery disease, caused by chronic arterial occlusion of the lower extremities, affects over 200 million people worldwide. Peripheral artery disease can progress into critical limb ischemia (CLI), its more severe manifestation, which is associated with higher risk of limb amputation and cardiovascular death. Aiming to improve tissue perfusion, therapeutic angiogenesis held promise to improve ischemic limbs using delivery of growth factors but has not successfully translated into benefits for patients. Moreover, accumulating studies suggest that impaired downstream signaling of these growth...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 2, 2020 Category: Cardiology Authors: Pérez-Cremades D, Cheng HS, Feinberg MW Tags: Arterioscler Thromb Vasc Biol Source Type: research

Stabilization of Perivascular Mast Cells by Endothelial CNP (C-Type Natriuretic Peptide).
CONCLUSIONS: CNP, via GC-B/cyclic GMP signaling, stabilizes resident perivascular MCs at baseline and prevents their excessive activation under pathological conditions. Thereby CNP contributes to the maintenance of vascular integrity in physiology and disease. PMID: 31893950 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 2, 2020 Category: Cardiology Authors: Chen W, Werner F, Illerhaus A, Knopp T, Völker K, Potapenko T, Hofmann U, Frantz S, Baba HA, Rösch M, Zernecke A, Karbach S, Wenzel P, Kuhn M Tags: Arterioscler Thromb Vasc Biol Source Type: research

APOE at the BBB: Pericyte-Derived Apolipoprotein E4 Diminishes Endothelial Cell Barrier Function.
PMID: 31869265 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Johnson LA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Natriuretic Peptides and the Regulation of Retinal Neovascularization.
PMID: 31869266 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Burtenshaw D, Cahill PA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Editors and Editorial Board.
Authors: PMID: 31869267 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Correction to: SCF (Stem Cell Factor) and cKIT Modulate Pathological Ocular Neovascularization.
Authors: PMID: 31869268 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

High Salt and IL (Interleukin)-17 in Aortic Dissection.
PMID: 31869269 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Sawada H, Gong MC, Guo Z, Daugherty A, Lu HS Tags: Arterioscler Thromb Vasc Biol Source Type: research

Human Microcirculation in Ischemic Heart Disease.
PMID: 31869270 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Sidik N, Morrow A, Berry C Tags: Arterioscler Thromb Vasc Biol Source Type: research

Foamy Monocytes, Extra Virgin Olive Oil and Nut-Enriched Diet, and Atheroprotection.
PMID: 31869271 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Reardon CA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Annual Report on Sex in Preclinical Studies: Arteriosclerosis, Thrombosis, and Vascular Biology Publications in 2018.
PMID: 31869272 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Does HDL (High-Density Lipoprotein) Play a Causal Role in Host Defenses Against Infection?
PMID: 31869273 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 25, 2019 Category: Cardiology Authors: Heinecke JW Tags: Arterioscler Thromb Vasc Biol Source Type: research

IL (Interleukin)-6 Contributes to Deep Vein Thrombosis and Is Negatively Regulated by miR-338-5p.
CONCLUSIONS: Our results suggest that decreased miR-338-5p promotes DVT formation by increasing IL-6 expression. PMID: 31852218 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Zhang Y, Zhang Z, Wei R, Miao X, Sun S, Liang G, Chu C, Zhao L, Zhu X, Guo Q, Wang B, Li X Tags: Arterioscler Thromb Vasc Biol Source Type: research

MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice.
CONCLUSIONS: Our data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target miR-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease. PMID: 31852219 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.
CONCLUSIONS: These results establish retinoid regulation of human cardiovascular calcification, provide new insight into mechanisms involved in these responses, and suggest selective retinoid modulators, like acyclic retinoids may allow for treating cardiovascular calcification without the adverse effects associated with cyclic retinoids. PMID: 31852220 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J Tags: Arterioscler Thromb Vasc Biol Source Type: research

Plasma Albumin and Incident Cardiovascular Disease: Results From the CGPS and an Updated Meta-Analysis.
CONCLUSIONS: There is a robust, independent association of low plasma albumin with CVD, partly explained by plasma albumin as a negative acute-phase reactant. CLINICAL TRIAL REGISTRATION: URL: Unique identifier: CRD42018095796. PMID: 31852221 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Ronit A, Kirkegaard-Klitbo DM, Dohlmann TL, Lundgren J, Sabin CA, Phillips AN, Nordestgaard BG, Afzal S Tags: Arterioscler Thromb Vasc Biol Source Type: research

2019 Russell Ross Memorial Lecture in Vascular Biology: B Lymphocyte-Mediated Protective Immunity in Atherosclerosis.
Abstract Atherosclerosis-the major underlying pathology of cardiovascular disease-is characterized by accumulation and subsequent oxidative modification of lipoproteins within the artery wall, leading to inflammatory cell infiltration and lesion formation that can over time result in arterial stenosis, ischemia, and downstream adverse events. The contribution of innate and adaptive immunity to atherosclerosis development is well established, and B cells have emerged as important modulators of both pro- and anti-inflammatory effects in atherosclerosis. Murine B cells can broadly be divided into 2 subsets: (1) B-2 c...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Upadhye A, Sturek JM, McNamara CA Tags: Arterioscler Thromb Vasc Biol Source Type: research

PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling.
CONCLUSIONS: Systemic PTEN elevation mediates protection against Ang II-induced vascular inflammation and fibrosis predominantly through effects in resident vascular cells. Our data highly support that pharmacological upregulation of PTEN could be a novel and viable approach for the treatment of pathological vascular fibrosis. PMID: 31852223 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Proinflammatory Mediators, IL (Interleukin)-1 β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression.
CONCLUSIONS: Overall, these new studies demonstrate that the major proinflammatory mediators, IL-1β, TNFα, and thrombin, are key regulators of capillary tube regression-a critical pathological process regulating human disease. PMID: 31852224 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 19, 2019 Category: Cardiology Authors: Koller GM, Schafer C, Kemp SS, Aguera KN, Lin PK, Forgy JC, Griffin CT, Davis GE Tags: Arterioscler Thromb Vasc Biol Source Type: research

Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation.
CONCLUSIONS: Despite well-documented roles of JAM-A and PECAM-1 for the regulation of endothelial junctions, only for ESAM we detected an essential role for endothelial barrier integrity in a tissue-specific way. In addition, we found that it is ESAM which prevents endothelial junction rupture in the lung when VE-cadherin is absent. PMID: 31826650 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 12, 2019 Category: Cardiology Authors: Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D Tags: Arterioscler Thromb Vasc Biol Source Type: research

Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON).
CONCLUSIONS: PELATON is a nuclear expressed, monocyte- and macrophage-specific lncRNA, upregulated in unstable atherosclerotic plaque. Knockdown of PELATON affects cellular functions associated with plaque progression. PMID: 31826651 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 12, 2019 Category: Cardiology Authors: Hung J, Scanlon JP, Mahmoud AD, Rodor J, Ballantyne M, Fontaine MAC, Temmerman L, Kaczynski J, Connor KL, Bhushan R, Biessen EAL, Newby DE, Sluimer JC, Baker AH Tags: Arterioscler Thromb Vasc Biol Source Type: research

Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.
CONCLUSIONS: These data demonstrate how endothelial glycocalyx function and functional adaptation to shear is coupled to KLF2-mediated regulation of endothelial glycolysis. PMID: 31826652 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 12, 2019 Category: Cardiology Authors: Wang G, Kostidis S, Tiemeier GL, Sol WMPJ, de Vries MR, Giera M, Carmeliet P, van den Berg BM, Rabelink TJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Intercellular Conduction Optimizes Arterial Network Function and Conserves Blood Flow Homeostasis During Cerebrovascular Challenges.
CONCLUSIONS: Our findings highlight the integral role of intercellular electrical signaling in transcribing focal stimuli into coordinated changes in cerebrovascular contractile activity and expose, a hitherto unknown mechanism for flow regulation after stroke. PMID: 31826653 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 12, 2019 Category: Cardiology Authors: Zechariah A, Tran CHT, Hald BO, Sandow SL, Sancho M, Kim MSM, Fabris S, Tuor UI, Gordon GRJ, Welsh DG Tags: Arterioscler Thromb Vasc Biol Source Type: research

Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UKB.
CONCLUSIONS: These findings replicate previously reported associations, highlight novel biology, and provide new directions for investigating the sex differences observed in cardiovascular disease presentation and progression. PMID: 31801372 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 5, 2019 Category: Cardiology Authors: Strawbridge RJ, Ward J, Bailey MES, Cullen B, Ferguson A, Graham N, Johnston KJA, Lyall LM, Pearsall R, Pell J, Shaw RJ, Tank R, Lyall DM, Smith DJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Causal Associations Between Serum Bilirubin Levels and Decreased Stroke Risk: A Two-Sample Mendelian Randomization Study.
Abstract OBJECTIVE: A number of epidemiological studies have reported that decreased serum bilirubin, an endogenous antioxidant, is associated with cardiovascular disease. However, previous Mendelian randomization analyses conducted using a single sample have shown no evidence of association. Approach and Results: A 2-sample summary Mendelian randomization study was performed by obtaining exposure and outcome data from separate nonoverlapping samples. We utilized data from the KoGES (Korean Genome and Epidemiology Study; n=25 406) and KCPS-II (Korean Cancer Prevention Study-II; n=14 541) biobank for serum bilirubi...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 5, 2019 Category: Cardiology Authors: Choi Y, Lee SJ, Spiller W, Jung KJ, Lee JY, Kimm H, Back JH, Lee S, Jee SH Tags: Arterioscler Thromb Vasc Biol Source Type: research