Delisting STAP1: The Rise and Fall of a Putative Hypercholesterolemia Gene.
PMID: 32208993 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2020 Category: Cardiology Authors: Hegele RA, Knowles JW, Horton JD Tags: Arterioscler Thromb Vasc Biol Source Type: research

Letter by Shar et al Regarding Article, "Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve: A Time-Resolved 3-Dimensional Phase-Contrast Magnetic Resonance Imaging Study".
Letter by Shar et al Regarding Article, "Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve: A Time-Resolved 3-Dimensional Phase-Contrast Magnetic Resonance Imaging Study". Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):e114-e115 Authors: Shar JA, Liu J, Atkins SK, Sucosky P PMID: 32208994 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2020 Category: Cardiology Authors: Shar JA, Liu J, Atkins SK, Sucosky P Tags: Arterioscler Thromb Vasc Biol Source Type: research

Correction to: Causal Associations Between Serum Bilirubin Levels and Decreased Stroke Risk: A Two-Sample Mendelian Randomization Study.
Authors: PMID: 32208995 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2020 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Response by Dux-Santoy et al to Letter Regarding Article, "Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve: A Time-Resolved 3-Dimensional Phase-Contrast Magnetic Resonance Imaging Study".
Response by Dux-Santoy et al to Letter Regarding Article, "Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve: A Time-Resolved 3-Dimensional Phase-Contrast Magnetic Resonance Imaging Study". Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):e116-e117 Authors: Dux-Santoy L, Guala A, Sotelo J, Uribe S, Teixidó-Turà G, Evangelista A, Rodríguez-Palomares JF PMID: 32208996 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2020 Category: Cardiology Authors: Dux-Santoy L, Guala A, Sotelo J, Uribe S, Teixidó-Turà G, Evangelista A, Rodríguez-Palomares JF Tags: Arterioscler Thromb Vasc Biol Source Type: research

Transitioning the Menopause: A Stiff Challenge.
PMID: 32208997 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2020 Category: Cardiology Authors: McEniery CM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections.
Abstract Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclero...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2020 Category: Cardiology Authors: Shen YH, LeMaire SA, Webb NR, Cassis LA, Daugherty A, Lu HS Tags: Arterioscler Thromb Vasc Biol Source Type: research

Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells.
Abstract Adipose tissues are present at multiple locations in the body. Most blood vessels are surrounded with adipose tissue which is referred to as perivascular adipose tissue (PVAT). Similarly to adipose tissues at other locations, PVAT harbors many types of cells which produce and secrete adipokines and other undetermined factors which locally modulate PVAT metabolism and vascular function. Uncoupling protein-1, which is considered as a brown fat marker, is also expressed in PVAT of rodents and humans. Thus, compared with other adipose tissues in the visceral area, PVAT displays brown-like characteristics. PVA...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Chang L, Garcia-Barrio MT, Chen YE Tags: Arterioscler Thromb Vasc Biol Source Type: research

Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity: The Paris Prospective Study III.
CONCLUSIONS: In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared with normal glucose metabolism subjects. PMID: 32188272 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Cseh D, Climie RE, Offredo L, Guibout C, Thomas F, Zanoli L, Danchin N, Sharman JE, Laurent S, Jouven X, Boutouyrie P, Empana JP Tags: Arterioscler Thromb Vasc Biol Source Type: research

Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.
Abstract OBJECTIVE: TMEM55B (transmembrane protein 55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI[4,5]P2) phosphatase that regulates cellular cholesterol, modulates LDLR (low-density lipoprotein receptor) decay, and lysosome function. We tested the effects of Tmem55b knockdown on plasma lipids in mice and assessed the roles of LDLR lysosomal degradation and change in (PI[4,5]P2) in mediating these effects. Approach and Results: Western diet-fed C57BL/6J mice were treated with antisense oligonucleotides against Tmem55b or a nontargeting control for 3 to 4 weeks. Hepatic Tmem55b transcript and protein levels ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Qin Y, Ting F, Kim MJ, Strelnikov J, Harmon J, Gao F, Dose A, Teng BB, Alipour MA, Yao Z, Crooke R, Krauss RM, Medina MW Tags: Arterioscler Thromb Vasc Biol Source Type: research

A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis.
dríguez JA, López-Andrés N Abstract OBJECTIVE: Aortic valve (AV) calcification plays an important role in the progression of aortic stenosis (AS). MMP-10 (matrix metalloproteinase-10 or stromelysin-2) is involved in vascular calcification in atherosclerosis. We hypothesize that MMP-10 may play a pathophysiological role in calcific AS. Approach and Results: Blood samples (n=112 AS and n=349 controls) and AVs (n=88) from patients undergoing valve replacement were analyzed. Circulating MMP-10 was higher in patients with AS compared with controls (P
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Matilla L, Roncal C, Ibarrola J, Arrieta V, García-Peña A, Fernández-Celis A, Navarro A, Álvarez V, Gainza A, Orbe J, Cachofeiro V, Zalba G, Sádaba R, Rodríguez JA, López-Andrés N Tags: Arterioscler Thromb Vasc Biol Source Type: research

Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice.
CONCLUSIONS: Partial inhibition of glycolysis restrained intraplaque angiogenesis without affecting plaque composition. However, less plaques were formed, which was accompanied by downregulation of endothelial adhesion molecules-an event that depends on autophagy induction. Inhibition of coronary plaque formation by 3PO resulted in an overall improved cardiac function (Visual Overview). PMID: 32188275 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Perrotta P, Van der Veken B, Van Der Veken P, Pintelon I, Roosens L, Adriaenssens E, Timmerman V, Guns PJ, De Meyer GRY, Martinet W Tags: Arterioscler Thromb Vasc Biol Source Type: research

Shear Stress-Induced miR-143-3p in Collateral Arteries Contributes to Outward Vessel Growth by Targeting Collagen V- α2.
CONCLUSIONS: These results indicate that the increased miR-143-3p expression in response to FSS might contribute to the reorganization of the extracellular matrix, which is important for vascular remodeling processes, by inhibiting collagen V-α2 biosynthesis (Visual Overview). PMID: 32188276 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Troidl K, Hammerschick T, Albarran-Juarez J, Jung G, Schierling W, Tonack S, Krüger M, Matuschke B, Troidl C, Schaper W, Schmitz-Rixen T, Preissner KT, Fischer S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Central Versus Peripheral Artery Stiffening and Cardiovascular Risk.
Abstract The large elastic arteries fulfill an important role in buffering the cyclical changes in blood pressure, which result from intermittent ventricular ejection. With aging and accrual of cardiovascular risk factors, the elastic arteries stiffen, and this process holds a number of deleterious consequences for the cardiovascular system and major organs. Indeed, arterial stiffness is now recognized as an important, independent determinant of cardiovascular disease risk. Additional, important information concerning the mechanisms underlying arterial stiffening has come from longitudinal studies of arterial stif...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: Yu S, McEniery CM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly.
CONCLUSIONS: Direct and indirect activation of Kv7 channels by the APAP metabolite N-acetyl-p-benzoquinone imine decreases arterial tone, which can lead to a drop in blood pressure. Our findings provide a molecular mechanism and potential preventive intervention for the clinical phenomenon of intravenous APAP-dependent transient hypotension. PMID: 32188278 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2020 Category: Cardiology Authors: van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Association Between Carotid Bifurcation Geometry and Atherosclerotic Plaque Vulnerability: A Chinese Atherosclerosis Risk Evaluation Study.
CONCLUSIONS: Smaller luminal expansion at carotid bifurcation is associated with vulnerable plaque. The finding needs to be verified with longitudinal studies and the underlying mechanism should be further explored with hemodynamics measurement in the future. PMID: 32160772 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2020 Category: Cardiology Authors: Jiang P, Chen Z, Hippe DS, Watase H, Sun B, Lin R, Yang Z, Xue Y, Zhao X, Yuan C Tags: Arterioscler Thromb Vasc Biol Source Type: research

Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions.
CONCLUSIONS: Together, these observations reveal that LMCD1 acts as an activator and repressor of E2F1 and NFATc1 in humans and mice, respectively, in the induction of CDC6 and IL-33 expression during development of vascular lesions. Based on these findings, LMCD could be a potential target for drug development against restenosis and atherosclerosis in humans. PMID: 32160773 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2020 Category: Cardiology Authors: Govatati S, Pichavaram P, Janjanam J, Guo L, Virmani R, Rao GN Tags: Arterioscler Thromb Vasc Biol Source Type: research

Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets.
n F Abstract Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although interventional treatment options have rapidly improved in recent years, symptomatic aortic valve stenosis is still associated with high morbidity and mortality. Calcific aortic valve stenosis is characterized by a progressive fibro-calcific remodeling and thickening of the aortic valve cusps, which subsequently leads to valve obstruction. The underlying pathophysiology is complex and involves endothelial dysfunction, immune cell infiltration, myofibroblastic and osteoblastic differentiation, and, subsequently, calcific...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2020 Category: Cardiology Authors: Goody PR, Hosen MR, Christmann D, Niepmann ST, Zietzer A, Adam M, Bönner F, Zimmer S, Nickenig G, Jansen F Tags: Arterioscler Thromb Vasc Biol Source Type: research

Sickle Cell Anemia Mediates Carotid Artery Expansive Remodeling That Can Be Prevented by Inhibition of JNK (c-Jun N-Terminal Kinase).
CONCLUSIONS: Arterial remodeling due to SCA is mediated by JNK signaling, cathepsin proteolytic upregulation, and degradation of elastin and collagen. Demonstration in Townes mice establishes their utility for mechanistic studies of arterial vasculopathy, related complications, and therapeutic interventions for large artery damage due to SCA. PMID: 32160775 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2020 Category: Cardiology Authors: Song H, Keegan PM, Anbazhakan S, Rivera CP, Feng Y, Omojola VO, Clark AA, Cai S, Selma J, Gleason RL, Botchwey EA, Huo Y, Tan W, Platt MO Tags: Arterioscler Thromb Vasc Biol Source Type: research

GFAP (Glial Fibrillary Acidic Protein)-Positive Progenitor Cells Contribute to the Development of Vascular Smooth Muscle Cells and Endothelial Cells.
CONCLUSIONS: Our study demonstrates that vascular smooth muscle cells and endothelial cells within the same vascular segment are developmentally heterogeneous, where varying proportions of vascular smooth muscle cells and endothelial cells are contributed by GFAP-positive progenitor cells. PMID: 32160776 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2020 Category: Cardiology Authors: Osman I, Wan L, Hu G, Zheng Z, Zhou J Tags: Arterioscler Thromb Vasc Biol Source Type: research

Identification of a Plasma MicroRNA Profile Associated With Venous Thrombosis.
Abstract OBJECTIVE: Venous thrombosis (VT) is a complex condition with a highly heritable genetic component that predisposes one to its development. Certain microRNAs (miRNAs) might be used as biomarkers of VT, but few studies have examined miRNA expression in this respect. The aim of the present work was to identify a plasma miRNA profile associated with VT. Approach and Results: miRNAs were analyzed by qPCR in plasma samples from members of the GAIT-2 (Genetic Analysis of Idiopathic Thrombophilia 2) population (n=935). A discovery phase involving the screening of 752 miRNAs from a subset of 104 GAIT-2 subjects w...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 12, 2020 Category: Cardiology Authors: Rodriguez-Rius A, Lopez S, Martinez-Perez A, Souto JC, Soria JM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis Via COX-1 (Cyclooxygenase-2).
Abstract OBJECTIVE: Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular dysfunction in cardiovascular disease and represent therapeutic targets in cardiovascular prevention. The object of this study was to define the platelet phenotype and effector cell properties on vascular health in psoriasis and evaluate whether aspirin modulates the platelet-induced phenotype. Approach and Results: Platelets from psoriasis patients (n=45) exhibited increased platelet activation (relative to age- and gender-matched controls,...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 5, 2020 Category: Cardiology Authors: Garshick MS, Tawil M, Barrett TJ, Salud-Gnilo CM, Eppler M, Lee A, Scher JU, Neimann AL, Jelic S, Mehta NN, Fisher EA, Krueger JG, Berger JS Tags: Arterioscler Thromb Vasc Biol Source Type: research

B Lymphocytes and Adipose Tissue Inflammation.
Abstract The immune system plays an important role in obesity-induced adipose tissue inflammation and the resultant metabolic dysfunction, which can lead to hypertension, dyslipidemia, and insulin resistance and their downstream sequelae of type II diabetes mellitus and cardiovascular disease. While macrophages are the most abundant immune cell type in adipose tissue, other immune cells are also present, such as B cells, which play important roles in regulating adipose tissue inflammation. This brief review will overview B-cell subsets, describe their localization in various adipose depots and summarize our knowle...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 5, 2020 Category: Cardiology Authors: Srikakulapu P, McNamara CA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres: Effects of HDL Particle Remodeling on Cholesterol Efflux.
CONCLUSIONS: These data demonstrate that although newly formed discs are relatively poor substrates for ABCA1, they can interact with spheres to produce lipid-poor apo AI, a much better substrate for ABCA1. Because the lipid-poor apo AI generated in this interaction can itself become discoid by the action of ABCA1, cycles of cholesterol efflux and disc-sphere fusion may result in net ABCA1-dependent transfer of cholesterol from cells to HDL spheres. This process may be of particular importance in atherosclerotic plaque where cholesterol acceptors may be limiting. PMID: 32131613 [PubMed - as supplied by publisher] (Sou...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 5, 2020 Category: Cardiology Authors: Navdaev AV, Sborgi L, Wright SD, Didichenko SA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Reactive Sulfur Species: A New Redox Player in Cardiovascular Pathophysiology.
Abstract Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator of critical biological processes. However, the physiological significance of hydrogen sulfide metabolites such as persulfides, polysulfides, and other reactive sulfur species (RSS) has only recently been appreciated. Emerging evidence suggests that these RSS molecules may have similar or divergent regulatory roles compared with hydrogen sulfide in various biological activities. However, the chemical nature of persulfides and polysulfides is complex and remains poorly understood within cardiovascular and other pathophys...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 5, 2020 Category: Cardiology Authors: Kolluru GK, Shen X, Kevil CG Tags: Arterioscler Thromb Vasc Biol Source Type: research

Leading the Long Noncoding RNA Pack: PELATON in Human Atherosclerosis.
PMID: 32101471 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 28, 2020 Category: Cardiology Authors: Rayner KJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Aortic Aneurysms and Dissections Series.
Abstract The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In response to changes in the biomechanical environment, aortic cells and extracellular matrix modulate their structure and functions to increase aortic wall strength and meet the hemodynamic demand. Compromise in the structural and functional integrity of aortic components leads to aortic degeneration, biomechanical failure, and the development of aortic aneurysms and dissections (AAD). A better understanding of the molecular pathogenesis of AAD will facilitate the development of effective medications to treat these ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 28, 2020 Category: Cardiology Authors: Shen YH, LeMaire SA, Webb NR, Cassis LA, Daugherty A, Lu HS Tags: Arterioscler Thromb Vasc Biol Source Type: research

Step by Step: Advancing the Understanding of Local Vascular Control.
PMID: 32101473 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 28, 2020 Category: Cardiology Authors: Chilian WM, Yin L, Ohanyan V Tags: Arterioscler Thromb Vasc Biol Source Type: research

PIM1 (Provirus Integration Site For Moloney Murine Leukemia Virus) as a Novel Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension: Another Evidence for Cancer Theory.
PMID: 32101474 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 28, 2020 Category: Cardiology Authors: Satoh K, Kikuchi N, Shimokawa H Tags: Arterioscler Thromb Vasc Biol Source Type: research

Retinoids: Dissolving the Calcification Paradox.
PMID: 32101475 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 28, 2020 Category: Cardiology Authors: St Hilaire C Tags: Arterioscler Thromb Vasc Biol Source Type: research

Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis.
CONCLUSIONS: These findings show that platelets can disseminate their EV in fluid that is inaccessible to platelets and beyond the joint in this disease. PMID: 32102567 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 27, 2020 Category: Cardiology Authors: Tessandier N, Melki I, Cloutier N, Allaeys I, Miszta A, Tan S, Milasan A, Michel S, Benmoussa A, Lévesque T, Côté F, McKenzie SE, Gilbert C, Provost P, Brisson AR, Wolberg AS, Fortin PR, Martel C, Boilard É Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo.
CONCLUSIONS: CM in vitro is procoagulant and prothrombotic. CM in vivo can augment myocardial damage and can be prohemostatic in the presence of bleeding. CM's procoagulant and antifibrinolytic activities likely involve, at least in part, its ability to bind factor Xa and enhance thrombin generation. Future work is needed to clarify CM's pathophysiology and its mechanistic influences on hemostasis or thrombosis. PMID: 32102568 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 27, 2020 Category: Cardiology Authors: Zilberman-Rudenko J, Deguchi H, Shukla M, Oyama Y, Orje JN, Guo Z, Wyseure T, Mosnier LO, McCarty OJT, Ruggeri ZM, Eckle T, Griffin JH Tags: Arterioscler Thromb Vasc Biol Source Type: research

Uses of Arterial Stiffness in Clinical Practice.
Mitchell GF Abstract As far back as the ancient Egyptians and Greeks, physicians have observed and interpreted the arterial pulse to diagnose disease. In the last 20 years, advances in modern engineering have rendered quantitative pulse wave analysis widely available, reliable, and reproducible. To date, measurement of arterial stiffness has remained almost exclusively a research activity. However, ongoing technological improvements coupled with already strong and growing evidence of clinical value should facilitate integration of arterial stiffness measures into clinical practice in the near future. This brief re...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 27, 2020 Category: Cardiology Authors: Wilkinson IB, Mäki-Petäjä KM, Mitchell GF Tags: Arterioscler Thromb Vasc Biol Source Type: research

Untargeted Lipidomics Reveals a Specific Enrichment in Plasmalogens in Epicardial Adipose Tissue and a Specific Signature in Coronary Artery Disease.
CONCLUSIONS: CAD is associated with specific lipidomic signature of EAT, unlike SAT. Plasma lipoprotein lipidome only partially reflected EAT lipidome. PMID: 32102570 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 27, 2020 Category: Cardiology Authors: Barchuk M, Dutour A, Ancel P, Svilar L, Miksztowicz V, Lopez G, Rubio M, Schreier L, Nogueira JP, Valero R, Beliard S, Martin JC, Berg G, Gaborit B Tags: Arterioscler Thromb Vasc Biol Source Type: research

HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure.
CONCLUSIONS: Our findings indicate that HuR regulates vascular smooth muscle contraction and maintains blood pressure by modulating RGS expression. PMID: 32075416 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Liu S, Jiang X, Lu H, Xing M, Qiao Y, Zhang C, Zhang W Tags: Arterioscler Thromb Vasc Biol Source Type: research

Etv2- and Fli1-Induced Vascular Progenitor Cells Enhance Functional Recovery in Ischemic Vascular Disease Model.
CONCLUSIONS: We demonstrate that ischemic disease curable iVPCs, which have self-renewal and bipotency, can be generated from mouse fibroblasts by enforced ETS family transcription factors, Etv2 and Fli1 expression. Our simple strategy opens insights into stem cell-based ischemic disease therapy. PMID: 32075417 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Park SY, Lee H, Kwon YW, Park MR, Kim JH, Kim JB Tags: Arterioscler Thromb Vasc Biol Source Type: research

Microvascular Disease Increases Amputation in Patients With Peripheral Artery Disease.
Abstract It is estimated that>2 million patients are living with an amputation in the United States. Peripheral artery disease (PAD) and diabetes mellitus account for the majority of nontraumatic amputations. The standard measurement to diagnose PAD is the ankle-brachial index, which integrates all occlusive disease in the limb to create a summary value of limb artery occlusive disease. Despite its accuracy, ankle-brachial index fails to well predict limb outcomes. There is an emerging body of literature that implicates microvascular disease (MVD; ie, retinopathy, nephropathy, neuropathy) as a systemic phenomen...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Behroozian A, Beckman JA Tags: Arterioscler Thromb Vasc Biol Source Type: research

Mechanisms of Arterial Stiffening: From Mechanotransduction to Epigenetics.
Abstract Arterial stiffness is a major independent risk factor for cardiovascular complications causing isolated systolic hypertension and increased pulse pressure in the microvasculature of target organs. Stiffening of the arterial wall is determined by common mechanisms including reduced elastin/collagen ratio, production of elastin cross-linking, reactive oxygen species-induced inflammation, calcification, vascular smooth muscle cell stiffness, and endothelial dysfunction. This brief review will discuss current biological mechanisms by which other cardiovascular risk factors (eg. aging, hypertension, diabetes m...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Lacolley P, Regnault V, Laurent S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Recipients of the 2020 Early Career Investigator Awards.
PMID: 32075420 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 20, 2020 Category: Cardiology Authors: Daugherty A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation.
CONCLUSIONS: The findings imply that endothelial FSTL1 is critical for the homeostasis of vascular walls, and its insufficiency may favor cardiovascular fibrosis leading to heart failure. PMID: 32078339 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 13, 2020 Category: Cardiology Authors: Jiang H, Zhang L, Liu X, Sun W, Kato K, Chen C, Li X, Li T, Sun Z, Han W, Zhang F, Xiao Q, Yang Z, Hu J, Qin Z, Adams RH, Gao X, He Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Warfarin Accelerates Medial Arterial Calcification in Humans.
CONCLUSIONS: Warfarin significantly accelerates medial arterial calcification in humans. This effect is markedly augmented in end-stage renal disease. PMID: 32078340 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 13, 2020 Category: Cardiology Authors: Alappan HR, Kaur G, Manzoor S, Navarrete J, O'Neill WC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Novel Long Noncoding RNA, Macrophage Inflammation-Suppressing Transcript (MIST), Regulates Macrophage Activation During Obesity.
CONCLUSIONS: Mist is a novel protective long noncoding RNA, and its loss during obesity contributes to metabolic dysfunction and proinflammatory phenotype of macrophages via epigenetic mechanisms. PMID: 32078363 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 13, 2020 Category: Cardiology Authors: Stapleton K, Das S, Reddy MA, Leung A, Amaram V, Lanting L, Chen Z, Zhang L, Palanivel R, Deiuliis JA, Natarajan R Tags: Arterioscler Thromb Vasc Biol Source Type: research

Atherosclerosis Immunoimaging by Positron Emission Tomography.
r WJM Abstract The immune system's role in atherosclerosis has long been an important research topic and is increasingly investigated for therapeutic and diagnostic purposes. Therefore, noninvasive imaging of hematopoietic organs and immune cells will undoubtedly improve atherosclerosis phenotyping and serve as a monitoring method for immunotherapeutic treatments. Among the available imaging techniques, positron emission tomography's unique features make it an ideal tool to quantitatively image the immune response in the context of atherosclerosis and afford reliable readouts to guide medical interventions in card...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Pérez-Medina C, Fayad ZA, Mulder WJM Tags: Arterioscler Thromb Vasc Biol Source Type: research

2019 ATVB Plenary Lecture: IL (Interleukin)-2 Therapy in Cardiovascular Disease: The Potential to Regulate Innate and Adaptive Immunity.
Abstract Regulatory T cells and type-2 innate lymphoid cells represent 2 subsets of immune cells, which have been shown in preclinical models to be important in atherosclerosis and myocardial repair. Regulatory T cells play a crucial role in immune homeostasis and tolerance via their interactions with effector T cells, dendritic cells, and monocytes/macrophages. They also utilize and secrete inhibitory cytokines, including interleukin 10 and transforming growth factor β, to regulate or suppress pathogenic immune responses. Type-2 innate lymphoid cells have an important role in type-2 immune responses and tiss...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Zhao TX, Newland SA, Mallat Z Tags: Arterioscler Thromb Vasc Biol Source Type: research

VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly.
urt-Dupuy E Abstract OBJECTIVE: To clarify the association between PCSK9 (proprotein convertase subtilisin/kexin type 9) and Lp(a) (Lipoprotein [a]), we studied Lp(a) kinetics in patients with loss-of-function and gain-of-function PCSK9 mutations and in patients in whom extended-release niacin reduced Lp(a) and PCSK9 concentrations. Approach and Results: Six healthy controls, 9 heterozygous patients with familial hypercholesterolemia (5 with low-density lipoprotein receptor [LDLR] mutations and 4 with PCSK9 gain-of-function mutations) and 3 patients with heterozygous dominant-negative PCSK9 loss-of-function mutati...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Croyal M, Blanchard V, Ouguerram K, Chétiveaux M, Cabioch L, Moyon T, Billon-Crossouard S, Aguesse A, Bernardeau K, Le May C, Flet L, Lambert G, Hadjadj S, Cariou B, Krempf M, Nobécourt-Dupuy E Tags: Arterioscler Thromb Vasc Biol Source Type: research

Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting.
CONCLUSIONS: Our data demonstrate that Cx37 expression is differentially regulated by shear stress and SMAD1/5 signaling, and that reduced Cx37 expression is permissive for capillary enlargement into shunts. PMID: 32078368 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Peacock HM, Tabibian A, Criem N, Caolo V, Hamard L, Deryckere A, Haefliger JA, Kwak BR, Zwijsen A, Jones EAV Tags: Arterioscler Thromb Vasc Biol Source Type: research

Total White Blood Cell Count Mediated the Association Between Increased Arterial Stiffness and Risk of Type 2 Diabetes Mellitus in Chinese Adults.
Abstract OBJECTIVE: Type 2 diabetes mellitus (T2DM) is known to be related to increased arterial stiffness. However, little is known about the risk of T2DM due to accelerated arterial stiffness and the underlying mechanism involved. We aimed to examine arterial stiffness, as determined by branchial-ankle pulse wave velocity (baPWV), in relation to diabetes mellitus among a community-based population and whether the association was mediated by white blood cell (WBC) counts. Approach and results: A total of 1036 Chinese adults aged 64.3 years with complete data were qualified in the present study. The dose-response ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 6, 2020 Category: Cardiology Authors: Liu Y, Lai X, Guo W, Ma L, Li W, Fang Q, Yang H, Cai Y, Liu M, Zhang X, Yang L Tags: Arterioscler Thromb Vasc Biol Source Type: research

Correction to: Shear Stress and VE-Cadherin: The Molecular Mechanism of Vascular Fusion.
Authors: PMID: 31967902 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Tags: Arterioscler Thromb Vasc Biol Source Type: research

Response by Fotakis et al to Letter Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques".
Response by Fotakis et al to Letter Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):e33-e34 Authors: Fotakis P, Kothari V, Bornfeldt KE, Tall AR PMID: 31967903 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: Fotakis P, Kothari V, Bornfeldt KE, Tall AR Tags: Arterioscler Thromb Vasc Biol Source Type: research

Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques".
Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):e31-e32 Authors: van der Vorst EPC, Biessen EAL, Donners MMPC PMID: 31967904 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: van der Vorst EPC, Biessen EAL, Donners MMPC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Metabolic Regulators of Vascular Inflammation.
PMID: 31967905 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2020 Category: Cardiology Authors: Fairman G, Robichaud S, Ouimet M Tags: Arterioscler Thromb Vasc Biol Source Type: research