Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The ARIC Study
CONCLUSIONS: Higher neutrophil, monocyte, and eosinophil counts in midlife are associated with higher risk of AAA, even after accounting for traditional risk factors such as smoking, obesity, and atherosclerosis. This suggests the need to identify nontraditional risk factors and treatment strategies to mitigate the residual risk of AAA conferred by midlife inflammation. Whether immunosuppression is associated with higher risk of AAA needs further investigation.PMID:34134517 | DOI:10.1161/ATVBAHA.121.315903 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Romil R Parikh Aaron R Folsom Kripa Poudel Pamela L Lutsey Ryan T Demmer James S Pankow Lin Y Chen Weihong Tang Source Type: research

Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men
CONCLUSIONS: Pubertal BMI change is an independent predictor of CAC score and risk of acute coronary events in adult men. Excessive BMI increase during puberty may initiate the coronary atherosclerotic process, thereby increasing the risk and severity of adult acute coronary events.PMID:34134518 | DOI:10.1161/ATVBAHA.121.316265 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Jenny M Kindblom Maria Bygdell Ola Hjelmgren Jari Martikainen Annika Rosengren G öran Bergström Claes Ohlsson Source Type: research

Common Polymorphism in the < em > FADS1 < /em > Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP-1
CONCLUSIONS: These findings uncover a mechanism whereby miR-1908-5p reduces TGFB1 abundance resulting in lower expression of BMP1, ultimately leading to reduced LDLR cleavage. Cleavage of the mature LDLR is known to reduce cell surface affinity for LDL, thereby linking miR-1908-5p to lower circulating LDL-cholesterol levels.PMID:34134519 | DOI:10.1161/ATVBAHA.121.316473 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Kaitlyn Beehler Majid Nikpay Paulina Lau Anh-Thu Dang Thomas A Lagace S ébastien Soubeyrand Ruth McPherson Source Type: research

Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects
CONCLUSIONS: The addition of niacin to statin therapy resulted in elevated levels of multiple HDL proteins linked to increased atherosclerotic risk, which might have compromised the cardioprotective effects associated with higher HDL-C levels and lower levels of LDL-C and triglycerides.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00715273; NCT00880178; NCT00120289.PMID:34134520 | DOI:10.1161/ATVBAHA.121.316278 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Graziella E Ronsein Tomas Vaisar W Sean Davidson Karin E Bornfeldt Jeffrey L Probstfield Kevin D O'Brien Xue-Qiao Zhao Jay W Heinecke Source Type: research

Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The ARIC Study
CONCLUSIONS: Higher neutrophil, monocyte, and eosinophil counts in midlife are associated with higher risk of AAA, even after accounting for traditional risk factors such as smoking, obesity, and atherosclerosis. This suggests the need to identify nontraditional risk factors and treatment strategies to mitigate the residual risk of AAA conferred by midlife inflammation. Whether immunosuppression is associated with higher risk of AAA needs further investigation.PMID:34134517 | DOI:10.1161/ATVBAHA.121.315903 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Romil R Parikh Aaron R Folsom Kripa Poudel Pamela L Lutsey Ryan T Demmer James S Pankow Lin Y Chen Weihong Tang Source Type: research

Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men
CONCLUSIONS: Pubertal BMI change is an independent predictor of CAC score and risk of acute coronary events in adult men. Excessive BMI increase during puberty may initiate the coronary atherosclerotic process, thereby increasing the risk and severity of adult acute coronary events.PMID:34134518 | DOI:10.1161/ATVBAHA.121.316265 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Jenny M Kindblom Maria Bygdell Ola Hjelmgren Jari Martikainen Annika Rosengren G öran Bergström Claes Ohlsson Source Type: research

Common Polymorphism in the < em > FADS1 < /em > Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP-1
CONCLUSIONS: These findings uncover a mechanism whereby miR-1908-5p reduces TGFB1 abundance resulting in lower expression of BMP1, ultimately leading to reduced LDLR cleavage. Cleavage of the mature LDLR is known to reduce cell surface affinity for LDL, thereby linking miR-1908-5p to lower circulating LDL-cholesterol levels.PMID:34134519 | DOI:10.1161/ATVBAHA.121.316473 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Kaitlyn Beehler Majid Nikpay Paulina Lau Anh-Thu Dang Thomas A Lagace S ébastien Soubeyrand Ruth McPherson Source Type: research

Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects
CONCLUSIONS: The addition of niacin to statin therapy resulted in elevated levels of multiple HDL proteins linked to increased atherosclerotic risk, which might have compromised the cardioprotective effects associated with higher HDL-C levels and lower levels of LDL-C and triglycerides.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00715273; NCT00880178; NCT00120289.PMID:34134520 | DOI:10.1161/ATVBAHA.121.316278 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Graziella E Ronsein Tomas Vaisar W Sean Davidson Karin E Bornfeldt Jeffrey L Probstfield Kevin D O'Brien Xue-Qiao Zhao Jay W Heinecke Source Type: research

Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The ARIC Study
CONCLUSIONS: Higher neutrophil, monocyte, and eosinophil counts in midlife are associated with higher risk of AAA, even after accounting for traditional risk factors such as smoking, obesity, and atherosclerosis. This suggests the need to identify nontraditional risk factors and treatment strategies to mitigate the residual risk of AAA conferred by midlife inflammation. Whether immunosuppression is associated with higher risk of AAA needs further investigation.PMID:34134517 | DOI:10.1161/ATVBAHA.121.315903 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Romil R Parikh Aaron R Folsom Kripa Poudel Pamela L Lutsey Ryan T Demmer James S Pankow Lin Y Chen Weihong Tang Source Type: research

Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men
CONCLUSIONS: Pubertal BMI change is an independent predictor of CAC score and risk of acute coronary events in adult men. Excessive BMI increase during puberty may initiate the coronary atherosclerotic process, thereby increasing the risk and severity of adult acute coronary events.PMID:34134518 | DOI:10.1161/ATVBAHA.121.316265 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Jenny M Kindblom Maria Bygdell Ola Hjelmgren Jari Martikainen Annika Rosengren G öran Bergström Claes Ohlsson Source Type: research

Common Polymorphism in the < em > FADS1 < /em > Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP-1
CONCLUSIONS: These findings uncover a mechanism whereby miR-1908-5p reduces TGFB1 abundance resulting in lower expression of BMP1, ultimately leading to reduced LDLR cleavage. Cleavage of the mature LDLR is known to reduce cell surface affinity for LDL, thereby linking miR-1908-5p to lower circulating LDL-cholesterol levels.PMID:34134519 | DOI:10.1161/ATVBAHA.121.316473 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Kaitlyn Beehler Majid Nikpay Paulina Lau Anh-Thu Dang Thomas A Lagace S ébastien Soubeyrand Ruth McPherson Source Type: research

Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects
CONCLUSIONS: The addition of niacin to statin therapy resulted in elevated levels of multiple HDL proteins linked to increased atherosclerotic risk, which might have compromised the cardioprotective effects associated with higher HDL-C levels and lower levels of LDL-C and triglycerides.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00715273; NCT00880178; NCT00120289.PMID:34134520 | DOI:10.1161/ATVBAHA.121.316278 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Graziella E Ronsein Tomas Vaisar W Sean Davidson Karin E Bornfeldt Jeffrey L Probstfield Kevin D O'Brien Xue-Qiao Zhao Jay W Heinecke Source Type: research

Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The ARIC Study
CONCLUSIONS: Higher neutrophil, monocyte, and eosinophil counts in midlife are associated with higher risk of AAA, even after accounting for traditional risk factors such as smoking, obesity, and atherosclerosis. This suggests the need to identify nontraditional risk factors and treatment strategies to mitigate the residual risk of AAA conferred by midlife inflammation. Whether immunosuppression is associated with higher risk of AAA needs further investigation.PMID:34134517 | DOI:10.1161/ATVBAHA.121.315903 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Romil R Parikh Aaron R Folsom Kripa Poudel Pamela L Lutsey Ryan T Demmer James S Pankow Lin Y Chen Weihong Tang Source Type: research

Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men
CONCLUSIONS: Pubertal BMI change is an independent predictor of CAC score and risk of acute coronary events in adult men. Excessive BMI increase during puberty may initiate the coronary atherosclerotic process, thereby increasing the risk and severity of adult acute coronary events.PMID:34134518 | DOI:10.1161/ATVBAHA.121.316265 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Jenny M Kindblom Maria Bygdell Ola Hjelmgren Jari Martikainen Annika Rosengren G öran Bergström Claes Ohlsson Source Type: research

Common Polymorphism in the < em > FADS1 < /em > Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP-1
CONCLUSIONS: These findings uncover a mechanism whereby miR-1908-5p reduces TGFB1 abundance resulting in lower expression of BMP1, ultimately leading to reduced LDLR cleavage. Cleavage of the mature LDLR is known to reduce cell surface affinity for LDL, thereby linking miR-1908-5p to lower circulating LDL-cholesterol levels.PMID:34134519 | DOI:10.1161/ATVBAHA.121.316473 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Kaitlyn Beehler Majid Nikpay Paulina Lau Anh-Thu Dang Thomas A Lagace S ébastien Soubeyrand Ruth McPherson Source Type: research

Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects
CONCLUSIONS: The addition of niacin to statin therapy resulted in elevated levels of multiple HDL proteins linked to increased atherosclerotic risk, which might have compromised the cardioprotective effects associated with higher HDL-C levels and lower levels of LDL-C and triglycerides.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00715273; NCT00880178; NCT00120289.PMID:34134520 | DOI:10.1161/ATVBAHA.121.316278 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Graziella E Ronsein Tomas Vaisar W Sean Davidson Karin E Bornfeldt Jeffrey L Probstfield Kevin D O'Brien Xue-Qiao Zhao Jay W Heinecke Source Type: research

Association of Differential Leukocyte Count With Incident Abdominal Aortic Aneurysm Over 22.5 Years: The ARIC Study
CONCLUSIONS: Higher neutrophil, monocyte, and eosinophil counts in midlife are associated with higher risk of AAA, even after accounting for traditional risk factors such as smoking, obesity, and atherosclerosis. This suggests the need to identify nontraditional risk factors and treatment strategies to mitigate the residual risk of AAA conferred by midlife inflammation. Whether immunosuppression is associated with higher risk of AAA needs further investigation.PMID:34134517 | DOI:10.1161/ATVBAHA.121.315903 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Romil R Parikh Aaron R Folsom Kripa Poudel Pamela L Lutsey Ryan T Demmer James S Pankow Lin Y Chen Weihong Tang Source Type: research

Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men
CONCLUSIONS: Pubertal BMI change is an independent predictor of CAC score and risk of acute coronary events in adult men. Excessive BMI increase during puberty may initiate the coronary atherosclerotic process, thereby increasing the risk and severity of adult acute coronary events.PMID:34134518 | DOI:10.1161/ATVBAHA.121.316265 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Jenny M Kindblom Maria Bygdell Ola Hjelmgren Jari Martikainen Annika Rosengren G öran Bergström Claes Ohlsson Source Type: research

Common Polymorphism in the < em > FADS1 < /em > Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP-1
CONCLUSIONS: These findings uncover a mechanism whereby miR-1908-5p reduces TGFB1 abundance resulting in lower expression of BMP1, ultimately leading to reduced LDLR cleavage. Cleavage of the mature LDLR is known to reduce cell surface affinity for LDL, thereby linking miR-1908-5p to lower circulating LDL-cholesterol levels.PMID:34134519 | DOI:10.1161/ATVBAHA.121.316473 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Kaitlyn Beehler Majid Nikpay Paulina Lau Anh-Thu Dang Thomas A Lagace S ébastien Soubeyrand Ruth McPherson Source Type: research

Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects
CONCLUSIONS: The addition of niacin to statin therapy resulted in elevated levels of multiple HDL proteins linked to increased atherosclerotic risk, which might have compromised the cardioprotective effects associated with higher HDL-C levels and lower levels of LDL-C and triglycerides.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00715273; NCT00880178; NCT00120289.PMID:34134520 | DOI:10.1161/ATVBAHA.121.316278 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 17, 2021 Category: Cardiology Authors: Graziella E Ronsein Tomas Vaisar W Sean Davidson Karin E Bornfeldt Jeffrey L Probstfield Kevin D O'Brien Xue-Qiao Zhao Jay W Heinecke Source Type: research

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316388. doi: 10.1161/ATVBAHA.121.316388. Online ahead of print.ABSTRACTOBJECTIVE: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Approach and Results...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Marco Orlandi Stefano Masi Devina Bhowruth Yago Leira Georgios Georgiopoulos Derek Yellon Aroon Hingorani Scott Chiesa Derek J Hausenloy John Deanfield Francesco D'Aiuto Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316388. doi: 10.1161/ATVBAHA.121.316388. Online ahead of print.ABSTRACTOBJECTIVE: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Approach and Results...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Marco Orlandi Stefano Masi Devina Bhowruth Yago Leira Georgios Georgiopoulos Derek Yellon Aroon Hingorani Scott Chiesa Derek J Hausenloy John Deanfield Francesco D'Aiuto Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316388. doi: 10.1161/ATVBAHA.121.316388. Online ahead of print.ABSTRACTOBJECTIVE: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Approach and Results...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Marco Orlandi Stefano Masi Devina Bhowruth Yago Leira Georgios Georgiopoulos Derek Yellon Aroon Hingorani Scott Chiesa Derek J Hausenloy John Deanfield Francesco D'Aiuto Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316388. doi: 10.1161/ATVBAHA.121.316388. Online ahead of print.ABSTRACTOBJECTIVE: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Approach and Results...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Marco Orlandi Stefano Masi Devina Bhowruth Yago Leira Georgios Georgiopoulos Derek Yellon Aroon Hingorani Scott Chiesa Derek J Hausenloy John Deanfield Francesco D'Aiuto Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316388. doi: 10.1161/ATVBAHA.121.316388. Online ahead of print.ABSTRACTOBJECTIVE: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Approach and Results...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Marco Orlandi Stefano Masi Devina Bhowruth Yago Leira Georgios Georgiopoulos Derek Yellon Aroon Hingorani Scott Chiesa Derek J Hausenloy John Deanfield Francesco D'Aiuto Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research

Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316388. doi: 10.1161/ATVBAHA.121.316388. Online ahead of print.ABSTRACTOBJECTIVE: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Approach and Results...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Marco Orlandi Stefano Masi Devina Bhowruth Yago Leira Georgios Georgiopoulos Derek Yellon Aroon Hingorani Scott Chiesa Derek J Hausenloy John Deanfield Francesco D'Aiuto Source Type: research

Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Arterioscler Thromb Vasc Biol. 2021 Jun 10:ATVBAHA121316256. doi: 10.1161/ATVBAHA.121.316256. Online ahead of print.ABSTRACTFueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Indeed, the in...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 10, 2021 Category: Cardiology Authors: Simon Kraler Peter Libby Paul C Evans Alexander Akhmedov Martin O Schmiady Michael Reinehr Giovanni G Camici Thomas F L üscher Source Type: research

Extracellular Vesicles and Hematopoietic Stem Cell Aging
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA120314643. doi: 10.1161/ATVBAHA.120.314643. Online ahead of print.ABSTRACTExtracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic processes and diseases. This, coupled with their tremendous capacity to influence hematopoiesis, suggests EVs may be key mediators ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Laura R Goldberg Source Type: research

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA121316300. doi: 10.1161/ATVBAHA.121.316300. Online ahead of print.NO ABSTRACTPMID:34078092 | DOI:10.1161/ATVBAHA.121.316300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Roy Jung Harish P Janardhan Karen Dresser Jennifer L Cotton Lloyd Hutchinson Junhao Mao Chinmay M Trivedi Source Type: research

Synthetic Fibrin-Derived B β15-42 Peptide Delays Thrombus Resolution in a Mouse Model
CONCLUSIONS: Our data suggest that excess of the fibrin fragment Bβ15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization.PMID:34078093 | DOI:10.1161/ATVBAHA.121.316404 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Stella Chausheva Bassam Redwan Smriti Sharma Nara Marella Klaudia Schossleitner Andr é C Mueller Peter Petzelbauer Timothy Morris Irene M Lang Source Type: research

Extracellular Vesicles and Hematopoietic Stem Cell Aging
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA120314643. doi: 10.1161/ATVBAHA.120.314643. Online ahead of print.ABSTRACTExtracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic processes and diseases. This, coupled with their tremendous capacity to influence hematopoiesis, suggests EVs may be key mediators ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Laura R Goldberg Source Type: research

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA121316300. doi: 10.1161/ATVBAHA.121.316300. Online ahead of print.NO ABSTRACTPMID:34078092 | DOI:10.1161/ATVBAHA.121.316300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Roy Jung Harish P Janardhan Karen Dresser Jennifer L Cotton Lloyd Hutchinson Junhao Mao Chinmay M Trivedi Source Type: research

Synthetic Fibrin-Derived B β15-42 Peptide Delays Thrombus Resolution in a Mouse Model
CONCLUSIONS: Our data suggest that excess of the fibrin fragment Bβ15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization.PMID:34078093 | DOI:10.1161/ATVBAHA.121.316404 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Stella Chausheva Bassam Redwan Smriti Sharma Nara Marella Klaudia Schossleitner Andr é C Mueller Peter Petzelbauer Timothy Morris Irene M Lang Source Type: research

Extracellular Vesicles and Hematopoietic Stem Cell Aging
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA120314643. doi: 10.1161/ATVBAHA.120.314643. Online ahead of print.ABSTRACTExtracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic processes and diseases. This, coupled with their tremendous capacity to influence hematopoiesis, suggests EVs may be key mediators ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Laura R Goldberg Source Type: research

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA121316300. doi: 10.1161/ATVBAHA.121.316300. Online ahead of print.NO ABSTRACTPMID:34078092 | DOI:10.1161/ATVBAHA.121.316300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Roy Jung Harish P Janardhan Karen Dresser Jennifer L Cotton Lloyd Hutchinson Junhao Mao Chinmay M Trivedi Source Type: research

Synthetic Fibrin-Derived B β15-42 Peptide Delays Thrombus Resolution in a Mouse Model
CONCLUSIONS: Our data suggest that excess of the fibrin fragment Bβ15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization.PMID:34078093 | DOI:10.1161/ATVBAHA.121.316404 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Stella Chausheva Bassam Redwan Smriti Sharma Nara Marella Klaudia Schossleitner Andr é C Mueller Peter Petzelbauer Timothy Morris Irene M Lang Source Type: research

Extracellular Vesicles and Hematopoietic Stem Cell Aging
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA120314643. doi: 10.1161/ATVBAHA.120.314643. Online ahead of print.ABSTRACTExtracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic processes and diseases. This, coupled with their tremendous capacity to influence hematopoiesis, suggests EVs may be key mediators ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Laura R Goldberg Source Type: research

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA121316300. doi: 10.1161/ATVBAHA.121.316300. Online ahead of print.NO ABSTRACTPMID:34078092 | DOI:10.1161/ATVBAHA.121.316300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Roy Jung Harish P Janardhan Karen Dresser Jennifer L Cotton Lloyd Hutchinson Junhao Mao Chinmay M Trivedi Source Type: research

Synthetic Fibrin-Derived B β15-42 Peptide Delays Thrombus Resolution in a Mouse Model
CONCLUSIONS: Our data suggest that excess of the fibrin fragment Bβ15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization.PMID:34078093 | DOI:10.1161/ATVBAHA.121.316404 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Stella Chausheva Bassam Redwan Smriti Sharma Nara Marella Klaudia Schossleitner Andr é C Mueller Peter Petzelbauer Timothy Morris Irene M Lang Source Type: research

Extracellular Vesicles and Hematopoietic Stem Cell Aging
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA120314643. doi: 10.1161/ATVBAHA.120.314643. Online ahead of print.ABSTRACTExtracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic processes and diseases. This, coupled with their tremendous capacity to influence hematopoiesis, suggests EVs may be key mediators ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Laura R Goldberg Source Type: research

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA121316300. doi: 10.1161/ATVBAHA.121.316300. Online ahead of print.NO ABSTRACTPMID:34078092 | DOI:10.1161/ATVBAHA.121.316300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Roy Jung Harish P Janardhan Karen Dresser Jennifer L Cotton Lloyd Hutchinson Junhao Mao Chinmay M Trivedi Source Type: research

Synthetic Fibrin-Derived B β15-42 Peptide Delays Thrombus Resolution in a Mouse Model
CONCLUSIONS: Our data suggest that excess of the fibrin fragment Bβ15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization.PMID:34078093 | DOI:10.1161/ATVBAHA.121.316404 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Stella Chausheva Bassam Redwan Smriti Sharma Nara Marella Klaudia Schossleitner Andr é C Mueller Peter Petzelbauer Timothy Morris Irene M Lang Source Type: research

Extracellular Vesicles and Hematopoietic Stem Cell Aging
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA120314643. doi: 10.1161/ATVBAHA.120.314643. Online ahead of print.ABSTRACTExtracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic processes and diseases. This, coupled with their tremendous capacity to influence hematopoiesis, suggests EVs may be key mediators ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Laura R Goldberg Source Type: research

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
Arterioscler Thromb Vasc Biol. 2021 Jun 3:ATVBAHA121316300. doi: 10.1161/ATVBAHA.121.316300. Online ahead of print.NO ABSTRACTPMID:34078092 | DOI:10.1161/ATVBAHA.121.316300 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Roy Jung Harish P Janardhan Karen Dresser Jennifer L Cotton Lloyd Hutchinson Junhao Mao Chinmay M Trivedi Source Type: research

Synthetic Fibrin-Derived B β15-42 Peptide Delays Thrombus Resolution in a Mouse Model
CONCLUSIONS: Our data suggest that excess of the fibrin fragment Bβ15-42 misguides thrombus resolution, presumably by inhibiting vascular endothelial cadherin-mediated leukocyte migration during early thrombus organization.PMID:34078093 | DOI:10.1161/ATVBAHA.121.316404 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 3, 2021 Category: Cardiology Authors: Stella Chausheva Bassam Redwan Smriti Sharma Nara Marella Klaudia Schossleitner Andr é C Mueller Peter Petzelbauer Timothy Morris Irene M Lang Source Type: research