SPEG Kinase: Hitting the Brake in Atrial Fibrillation.
PMID: 32955933 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Blackwell DJ, Knollmann BC Tags: Circulation Source Type: research

Reply by Kuck to Letter Regarding Article, "Preventive or Deferred Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy and Implantable Defibrillator (BERLIN VT): A Multicenter Randomized Trial".
Reply by Kuck to Letter Regarding Article, "Preventive or Deferred Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy and Implantable Defibrillator (BERLIN VT): A Multicenter Randomized Trial". Circulation. 2020 Sep 22;142(12):e186 Authors: Kuck KH PMID: 32955934 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Kuck KH Tags: Circulation Source Type: research

Victims of Success in Failure.
PMID: 32955935 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Lam CSP, Butler J Tags: Circulation Source Type: research

Letter by Krisai et al Regarding Article, "Preventive or Deferred Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy and Implantable Defibrillator (BERLIN VT): A Multicenter Randomized Trial".
Letter by Krisai et al Regarding Article, "Preventive or Deferred Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy and Implantable Defibrillator (BERLIN VT): A Multicenter Randomized Trial". Circulation. 2020 Sep 22;142(12):e184-e185 Authors: Krisai P, Vlachos K, Jaïs P PMID: 32955936 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Krisai P, Vlachos K, Jaïs P Tags: Circulation Source Type: research

Distinct Cardiac Transcriptomic Clustering in Titin and Lamin A/C-Associated Dilated Cardiomyopathy Patients.
PMID: 32955937 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Verdonschot JAJ, Derks KWJ, Hazebroek MR, Wang P, Robinson EL, Adriaens ME, Krapels IPC, van den Wijngaard A, Brunner HG, Heymans SRB Tags: Circulation Source Type: research

Wide Complex QRS Rhythm in a 52-Year-Old Man With Altered Mental Status.
PMID: 32955938 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Krivda JS, Williams MU, Arrey-Mbi TB Tags: Circulation Source Type: research

Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure: The Need for Further Evidence Generation and Practice Guidelines Optimization.
Abstract With worsening epidemiological trends for both the incidence and prevalence of type 2 diabetes mellitus (T2DM) and heart failure (HF) worldwide, it is critical to implement optimal prevention and treatment strategies for patients with these comorbidities, either alone or concomitantly. Several guidelines and consensus statements have recommended glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter type 2 inhibitors as add-ons to lifestyle interventions with or without metformin in those at high atherosclerotic cardiovascular disease risk. However, these recommendations are either sil...
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Khan MS, Fonarow GC, McGuire DK, Hernandez AF, Vaduganathan M, Rosenstock J, Handelsman Y, Verma S, Anker SD, McMurray JJV, Kosiborod MN, Butler J Tags: Circulation Source Type: research

ECMO Therapy for Cardiac Lymphoma.
PMID: 32955940 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 22, 2020 Category: Cardiology Authors: Leef G, Gladstone DE, Cingolani O Tags: Circulation Source Type: research

Trends in Recurrent Coronary Heart Disease Following Myocardial Infarction Among US Women and Men Between 2008 and 2017.
Abstract Background: Rates for recurrent coronary heart disease (CHD) events have declined in the US. However, few studies have assessed whether this decline has been similar among women and men. Methods: Data were used from 770,408 US women and 700,477 US men
Source: Circulation - September 21, 2020 Category: Cardiology Authors: Peters SAE, Colantonio LD, Dai Y, Zhao H, Bittner VA, Farkouh ME, Dluzniewski P, Poudel B, Muntner P, Woodward M Tags: Circulation Source Type: research

Ten-Year Differences in Women's Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association.
CONCLUSIONS: Awareness that heart disease is the LCOD among women declined from 2009 to 2019, particularly among Hispanic and non-Hispanic Black women and in younger women (in whom primordial/primary prevention may be most effective). An urgent redoubling of efforts by organizations interested in women's health is required to reverse these trends. PMID: 32954796 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 21, 2020 Category: Cardiology Authors: Cushman M, Shay CM, Howard VJ, Jiménez MC, Lewey J, McSweeney JC, Newby LK, Poudel R, Reynolds HR, Rexrode KM, Sims M, Mosca LJ, American Heart Association Tags: Circulation Source Type: research

Neutrophils and Contact Activation of Coagulation as Potential Drivers of Covid-19.
ate H, Nicolaes GAF, Reutelingsperger CP, van Paassen P PMID: 32946302 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 18, 2020 Category: Cardiology Authors: Busch MH, Timmermans SAMEG, Nagy M, Visser M, Huckriede J, Aendekerk JP, de Vries F, Potjewijd J, Jallah B, Ysermans R, Oude Lashof AML, Breedveld PH, van de Poll MCG, van der Horst ICC, van Bussel BCT, Theunissen ROMFIH, Spronk HMH, Damoiseaux JGMC, Ten Tags: Circulation Source Type: research

The COVID-19 pandemic: a massive threat for those living with cardiovascular disease among the poorest billion.
PMID: 32948096 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 18, 2020 Category: Cardiology Authors: Klassen SL, Kwan GF, Bukhman G Tags: Circulation Source Type: research

Signalosome-Regulated SRF Phosphorylation Determining Myocyte Growth in Width versus Length as a Therapeutic Target for Heart Failure.
Conclusions: We have identified a new molecular switch, namely mAKAPβ signalosome-regulated SRF phosphorylation, that controls a transcriptional program responsible for modulating changes in cardiac myocyte morphology that occur secondary to pathological stressors. Complementary AAV-based gene therapies constitute rationally-designed strategies for a new translational modality for heart failure. PMID: 32933333 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 16, 2020 Category: Cardiology Authors: Li J, Tan Y, Passariello CL, Martinez EC, Kritzer MD, Li X, Li X, Li Y, Yu Q, Ohgi K, Thakur H, MacArthur JW, Ivey JR, Woo YJ, Emter CA, Dodge-Kafka K, Rosenfeld MG, Kapiloff MS Tags: Circulation Source Type: research

Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community.
Conclusions: In a large sample of community-dwelling individuals, acute exercise elicits widespread changes in the circulating metabolome. Metabolic changes identify pathways central to cardiometabolic health, CVD, and long-term outcome. These findings provide a detailed map of the metabolic response to acute exercise in humans and identify potential mechanisms responsible for the beneficial cardiometabolic effects of exercise for future study. PMID: 32927962 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Nayor M, Shah RV, Miller PE, Blodgett JB, Tanguay M, Pico AR, Murthy VL, Malhotra R, Houstis NE, Deik A, Pierce KA, Bullock K, Dailey L, Velagaleti RS, Moore SA, Ho JE, Baggish AL, Clish CB, Larson MG, Vasan RS, Lewis GD Tags: Circulation Source Type: research

Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S Calm1 Mutation.
Conclusions: Heterozygosity for the Calm1N98S mutation is causative of an arrhythmia syndrome characterized by sinus bradycardia, QRS widening, adrenergically mediated QTc interval prolongation and bidirectional ventricular tachycardia. β-adrenergically induced ICa.L dysregulation contributes to the long QT phenotype. Pause-dependent early afterdepolarizations and tachycardia-induced delayed afterdepolarizations originating in the His-Purkinje network and ventricular myocytes, respectively, constitute potential sources of arrhythmia in Calm1N98S/+ hearts. PMID: 32929985 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Tsai WC, Guo S, Olaopa MA, Field LJ, Yang J, Shen C, Chang CP, Chen PS, Rubart M Tags: Circulation Source Type: research

Single-Cell RNA-seq Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells.
Conclusions: In summary, we use scRNA-seq data generated by the Tabula Muris consortium to uncover transcriptional networks that maintain tissue-specific EC identity and to identify novel angiocrine and functional relationships between tissue-specific ECs. PMID: 32929989 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Paik DT, Tian L, Williams IM, Rhee S, Zhang H, Liu C, Mishra R, Wu SM, Red-Horse K, Wu JC Tags: Circulation Source Type: research

Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association.
Abstract Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de pointes. Perhaps less familiar to clinicians is the fact that drugs can also trigger other arrhythmias, including bradyarrhythmias, atrial fibrillation/atrial flutter, atrial tachycardia, atrioventricular nodal reentrant tachycardia, monomorphic ventricular tachy...
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Tisdale JE, Chung MK, Campbell KB, Hammadah M, Joglar JA, Leclerc J, Rajagopalan B, American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing Tags: Circulation Source Type: research

Sodium-Glucose Cotransporter-2 Inhibitors and Loop Diuretics for Heart Failure: Priming the Natriuretic and Metabolic Reserve of the Kidney.
PMID: 32924569 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Grodin JL, Tang WHW Tags: Circulation Source Type: research

Letter by Kizawa et al Regarding Article, "Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study".
Letter by Kizawa et al Regarding Article, "Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study". Circulation. 2020 Sep 15;142(11):e154-e155 Authors: Kizawa R, Hara T, Miura Y PMID: 32924570 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Kizawa R, Hara T, Miura Y Tags: Circulation Source Type: research

Association of Black Cardiologists Calls for Urgent Effort to Address Health Inequity and Diversity in Cardiology.
PMID: 32924571 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Kuehn BM Tags: Circulation Source Type: research

Letter by Ren et al Regarding Article, "Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study".
Letter by Ren et al Regarding Article, "Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study". Circulation. 2020 Sep 15;142(11):e156-e157 Authors: Ren C, Li P, Chen HZ PMID: 32924572 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Ren C, Li P, Chen HZ Tags: Circulation Source Type: research

What Is the Risk?
PMID: 32924573 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Lutz K, Simpson TF, Dewland TA Tags: Circulation Source Type: research

Response by Khosrow-Khavar et al to Letters Regarding Article, "Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study".
Response by Khosrow-Khavar et al to Letters Regarding Article, "Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study". Circulation. 2020 Sep 15;142(11):e158-e159 Authors: Khosrow-Khavar F, Filion KB, Bouganim N, Suissa S, Azoulay L PMID: 32924574 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Khosrow-Khavar F, Filion KB, Bouganim N, Suissa S, Azoulay L Tags: Circulation Source Type: research

Solitary Left Ventricular Septal Mass and Amaurosis Fugax.
PMID: 32924575 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Velangi PS, Said SM, Nijjar PS Tags: Circulation Source Type: research

Contextual Imaging: A Requisite Concept for the Emergence of Point-of-Care Ultrasound.
PMID: 32924576 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 15, 2020 Category: Cardiology Authors: Kimura BJ, DeMaria AN Tags: Circulation Source Type: research

Established Cardiovascular Biomarkers Provide Limited Prognostic Information in Unselected Patients Hospitalized with COVID-19.
ensson M, Berdal JE, Myhre PL PMID: 32910681 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 10, 2020 Category: Cardiology Authors: Omland T, Prebensen C, Røysland R, Søvik S, Sørensen V, Røsjø H, Svensson M, Berdal JE, Myhre PL Tags: Circulation Source Type: research

CD4+ T-Cell Endogenous Cystathionine γ Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.
Conclusions: The constitutive sulfhydration of LKB1 by CSE-derived H2S activates its target kinase, AMPK, and promotes Treg differentiation and proliferation, which attenuates the vascular and renal immune-inflammation, thereby preventing hypertension. PMID: 32900241 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 9, 2020 Category: Cardiology Authors: Cui C, Fan J, Zeng Q, Cai J, Chen Y, Chen Z, Wang W, Li SY, Cui Q, Yang J, Tang C, Xu G, Cai J, Geng B Tags: Circulation Source Type: research

Immune Checkpoint Inhibitor Therapy Induces Inflammatory Activity in Large Arteries.
PMID: 32894978 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Calabretta R, Hoeller C, Pichler V, Mitterhauser M, Karanikas G, Haug A, Li X, Hacker M Tags: Circulation Source Type: research

Zero Coronary Artery Calcium Score: Desirable, but Enough?
PMID: 32897743 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Hussain A, Ballantyne CM, Nambi V Tags: Circulation Source Type: research

Correction to: Calcineurin A β-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.
Correction to: Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy. Circulation. 2020 Sep 08;142(10):e153 Authors: PMID: 32897744 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Tags: Circulation Source Type: research

Familial Legacy of Thoracic Aortic Aneurysm.
PMID: 32897745 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Elefteriades JA, Ziganshin BA Tags: Circulation Source Type: research

Altered Hemodynamics and End-Organ Damage in Heart Failure: Impact on the Lung and Kidney.
Abstract Heart failure is characterized by pathologic hemodynamic derangements, including elevated cardiac filling pressures ("backward" failure), which may or may not coexist with reduced cardiac output ("forward" failure). Even when normal during unstressed conditions such as rest, hemodynamics classically become abnormal during stressors such as exercise in patients with heart failure. This has important upstream and downstream effects on multiple organ systems, particularly with respect to the lungs and kidneys. Hemodynamic abnormalities in heart failure are affected by processes that exten...
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Verbrugge FH, Guazzi M, Testani JM, Borlaug BA Tags: Circulation Source Type: research

Electrocardiogram Exposing 2 Worrisome Vital Signs.
PMID: 32897747 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Littmann L Tags: Circulation Source Type: research

Cardiologists Urged to Help Reduce Heart-Related Maternal Mortality.
PMID: 32897748 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Kuehn BM Tags: Circulation Source Type: research

Racial Differences in Serial NT-proBNP Levels in Heart Failure Management: Insights From the GUIDE-IT Trial.
PMID: 32897749 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Parcha V, Patel N, Kalra R, Arora G, Januzzi JL, Felker GM, Wang TJ, Arora P Tags: Circulation Source Type: research

Letter by Chen et al Regarding Article, "Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial".
Letter by Chen et al Regarding Article, "Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial". Circulation. 2020 Sep 08;142(10):e127-e128 Authors: Chen ZQ, Chen F, Li L PMID: 32897750 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Chen ZQ, Chen F, Li L Tags: Circulation Source Type: research

A Phosphatase Anchor Weighs on the Heart.
PMID: 32897751 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Woulfe KC, Travers JG, McKinsey TA Tags: Circulation Source Type: research

Response by Zelniker et al to Letter Regarding Article, "Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial".
Response by Zelniker et al to Letter Regarding Article, "Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: Insights From the DECLARE-TIMI 58 Trial". Circulation. 2020 Sep 08;142(10):e129-e130 Authors: Zelniker TA, Raz I, Sabatine MS, Wiviott SD PMID: 32897752 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Zelniker TA, Raz I, Sabatine MS, Wiviott SD Tags: Circulation Source Type: research

Enrichment of Rare Variants in Loeys-Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia.
li M, Sprynger M, Toubiana L, European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI), Van Laer L, Van Dijk FS, Vikkula M, Samani NJ, Persu A, Adlam D, Loeys B, Collaborators of the European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI) PMID: 32897753 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 8, 2020 Category: Cardiology Authors: Verstraeten A, Perik MHAM, Baranowska AA, Meester JAN, Van Den Heuvel L, Bastianen J, Kempers M, Krapels IPC, Maas A, Rideout A, Vandersteen A, Sobey G, Johnson D, Fransen E, Ghali N, Webb T, Al-Hussaini A, de Leeuw P, Delmotte P, Lopez-Sublet M, Pappacco Tags: Circulation Source Type: research

Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.
Conclusions: Ninj1 is a novel MMP9 substrate in macrophages, and sNinj1 is a secreted athero-protective protein that regulates macrophage inflammation and monocyte recruitment in atherosclerosis. Moreover, sNinj1-mediated anti-inflammatory effects are conserved in human macrophages and likely contribute to human atherosclerosis. PMID: 32883094 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 4, 2020 Category: Cardiology Authors: Jeon S, Kim TK, Jeong SJ, Jung IH, Kim N, Lee MN, Sonn SK, Seo S, Jin J, Kweon HY, Kim S, Shim D, Park YM, Lee SH, Kim KW, Cybulsky MI, Shim H, Roh TY, Park WY, Lee HO, Choi JH, Park SH, Oh GT Tags: Circulation Source Type: research

Effect of Dapagliflozin on Outpatient Worsening of Patients with Heart Failure and Reduced Ejection Fraction: A Prespecified Analysis of DAPA-HF.
We examined the frequency and significance of episodes of outpatient heart failure-worsening, requiring augmentation of oral therapy, and the effects of dapagliflozin on these additional events. Methods: Patients in New York Heart Association (NYHA) functional class II-IV, with a left ventricular ejection fraction ≤40%, and elevation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) were eligible. The primary outcome was the composite of an episode of worsening heart failure (HF hospitalization or urgent HF visit requiring intravenous [IV] therapy) or cardiovascular (CV) death, whichever occurred first. An additi...
Source: Circulation - September 4, 2020 Category: Cardiology Authors: Docherty KF, Jhund PS, Anand I, Bengtsson O, Böhm M, de Boer RA, DeMets DL, Desai AS, Drozdz J, Howlett J, Inzucchi SE, Johanson P, Katova T, Køber L, Kosiborod MN, Langkilde AM, Lindholm D, Martinez FA, Merkely B, Nicolau JC, O'Meara E, Ponikowski P, S Tags: Circulation Source Type: research

An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility.
Conclusions: The results suggest an important role of DNA methylation in the normal homeostasis of cardiomyocytes and during cardiac stress, which could make it an interesting target for cardiac therapy. PMID: 32885664 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 4, 2020 Category: Cardiology Authors: Madsen A, Höppner G, Krause J, Hirt MN, Laufer SD, Schweizer M, Tan WLW, Mosqueira D, Anene-Nzelu CG, Lim I, Foo RSY, Eschenhagen T, Stenzig J Tags: Circulation Source Type: research

Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics.
Conclusions: Large-scale human plasma proteomics, cross-referenced to unbiased cardiac cell transcriptomics at single-cell resolution, prioritized protein candidates associated with post-MI HF for further mechanistic and clinical validation. PMID: 32885678 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 4, 2020 Category: Cardiology Authors: Chan MY, Efthymios M, Tan SH, Pickering JW, Troughton R, Pemberton C, Ho HH, Prabath JF, Drum CL, Ling LH, Soo WM, Chai SC, Fong A, Oon YY, Loh JP, Lee CH, Foo RSY, Ackers-Johnson MA, Pilbrow A, Richards AM Tags: Circulation Source Type: research

Lifelong Aspirin for All in the Secondary Prevention of Chronic Coronary Syndrome: Still Sacrosanct or is Reappraisal Warranted?
Abstract Four decades have passed since the first trial suggesting aspirin's efficacy in the secondary prevention of myocardial infarction. Further trials, summarized in the Antithrombotic Trialists' Collaboration, solidified the historical role of aspirin in secondary prevention. Although the benefit of aspirin in the immediate phase following a myocardial infarction remains incontrovertible, a number of emerging lines of evidence - discussed in this narrative review - now raise some uncertainty as to the primacy of aspirin for the lifelong management of all patients with chronic coronary syndrome (CCS). For exam...
Source: Circulation - September 4, 2020 Category: Cardiology Authors: Jacobsen AP, Raber I, McCarthy CP, Blumenthal RS, Bhatt DL, Cusack RW, Serruys PW, Wijns W, McEvoy JW Tags: Circulation Source Type: research

Severe COVID-19 is a Microvascular Disease.
PMID: 32877231 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - September 2, 2020 Category: Cardiology Authors: Lowenstein CJ, Solomon SD Tags: Circulation Source Type: research

Assigning Distal Genomic Enhancers to Cardiac Disease-Causing Genes.
PMID: 32866060 [PubMed - in process] (Source: Circulation)
Source: Circulation - September 1, 2020 Category: Cardiology Authors: Anene-Nzelu CG, Tan WLW, Lee CJM, Wenhao Z, Perrin A, Dashi A, Tiang Z, Autio MI, Lim B, Wong E, Tan HS, Pan B, Morley MP, Margulies KB, Cappola TP, Foo RS Tags: Circulation Source Type: research

Who Benefits From Taking a Statin, and When?: On Fundamentally Restructuring Our Thinking Regarding Primary Prevention of Cardiovascular Disease.
PMID: 32866062 [PubMed - in process] (Source: Circulation)
Source: Circulation - September 1, 2020 Category: Cardiology Authors: Leening MJG Tags: Circulation Source Type: research

Phenomics, Not Genomics, for Cardiovascular Risk Assessment.
PMID: 32866063 [PubMed - in process] (Source: Circulation)
Source: Circulation - September 1, 2020 Category: Cardiology Authors: Wierzbicki AS Tags: Circulation Source Type: research

Letter by Wang et al Regarding Article, "Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction".
Letter by Wang et al Regarding Article, "Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction". Circulation. 2020 Sep;142(9):e123-e124 Authors: Wang D, Wang T, Yang X PMID: 32866064 [PubMed - in process] (Source: Circulation)
Source: Circulation - September 1, 2020 Category: Cardiology Authors: Wang D, Wang T, Yang X Tags: Circulation Source Type: research

An Unusual, Reversible Cause of Acute High-Output Heart Failure Complicated by Refractory Shock.
PMID: 32866065 [PubMed - in process] (Source: Circulation)
Source: Circulation - September 1, 2020 Category: Cardiology Authors: Durstenfeld MS, Hsue PY Tags: Circulation Source Type: research