Preventive or Deferred Ablation of Ventricular Tachycardia in Patients with Ischemic Cardiomyopathy and Implantable Defibrillator (BERLIN VT): A Multicenter Randomized Trial.
Conclusions: Preventive VT ablation before ICD implantation did not reduce mortality or hospitalization for arrhythmia or worsening heart failure during 1 year of follow-up when compared to the deferred ablation strategy. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02501005. PMID: 32000514 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 31, 2020 Category: Cardiology Authors: Willems S, Tilz RR, Steven D, Kääb S, Wegscheider K, Geller L, Meyer C, Heeger CH, Metzner A, Sinner MF, Schlüter M, Nordbeck P, Eckardt L, Bogossian H, Sultan A, Wenzel B, Kuck KH, BERLIN VT investigators Tags: Circulation Source Type: research

Recommendations for Cardiovascular Health and Disease Surveillance for 2030 and Beyond: A Policy Statement From the American Heart Association.
We describe the action and components necessary to create the cardiovascular health and cardiovascular disease surveillance system of the future, steps in development, and challenges that federal, state, and local governments will need to address. Development of robust policies and commitment to collaboration among professional organizations, community partners, and policy makers are critical to ultimately reduce the burden of cardiovascular disease and improve cardiovascular health and to evaluate whether national health goals are achieved. PMID: 31992050 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 29, 2020 Category: Cardiology Authors: Roger VL, Sidney S, Fairchild AL, Howard VJ, Labarthe DR, Shay CM, Tiner AC, Whitsel LP, Rosamond WD, American Heart Association Advocacy Coordinating Committee Tags: Circulation Source Type: research

The American Heart Association 2030 Impact Goal: A Presidential Advisory From the American Heart Association.
, Saucedo JF, Shay CM, Siedzik D, Saha S, Warner JJ Abstract Each decade, the American Heart Association (AHA) develops an Impact Goal to guide its overall strategic direction and investments in its research, quality improvement, advocacy, and public health programs. Guided by the AHA's new Mission Statement, to be a relentless force for a world of longer, healthier lives, the 2030 Impact Goal is anchored in an understanding that to achieve cardiovascular health for all, the AHA must include a broader vision of health and well-being and emphasize health equity. In the next decade, by 2030, the AHA will strive to e...
Source: Circulation - January 29, 2020 Category: Cardiology Authors: Angell SY, McConnell MV, Anderson CAM, Bibbins-Domingo K, Boyle DS, Capewell S, Ezzati M, de Ferranti S, Gaskin DJ, Goetzel RZ, Huffman MD, Jones M, Khan YM, Kim S, Kumanyika SK, McCray AT, Merritt RK, Milstein B, Mozaffarian D, Norris T, Roth GA, Sacco R Tags: Circulation Source Type: research

Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association.
CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, healthcare administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions. PMID: 31992061 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 29, 2020 Category: Cardiology Authors: Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longeneck Tags: Circulation Source Type: research

Long-Term Safety and Efficacy of Durable Polymer Cobalt-Chromium Everolimus-Eluting Stents in Patients at High Bleeding Risk: A Patient-Level Stratified Analysis from Four Post-Approval Studies.
Conclusions: Compared to the non-HBR population, HBR patients experienced worse 4-year outcomes after PCI with CoCr everolimus-eluting stent. Both CTE and MB had a significant impact on subsequent risk of mortality irrespective of bleeding risk. PMID: 31992063 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 29, 2020 Category: Cardiology Authors: Sorrentino S, Claessen BE, Chandiramani R, Guedeney P, Vogel B, Baber U, Rau V, Wang J, Krucoff M, Kozuma K, Ge J, Seth A, Makkar R, Liu Y, Bangalore S, Bhatt DL, Angiolillo DJ, Saito S, Neumann FJ, Hermiller J, Valgimigli M, Mehran R Tags: Circulation Source Type: research

Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus: Lessons Learned and Future Directions.
Abstract Responding to concerns about the potential for increased risk of adverse cardiovascular (CV) outcomes, specifically myocardial infarction, associated with certain glucose-lowering therapies, the U.S. Food and Drug Administration and the Committee for Medicinal Products for Human Use of the European Medicines Agency issued guidance to the pharmaceutical industry in 2008. Glucose-lowering therapies were primarily granted regulatory approval from smaller studies that have demonstrated reductions in glycated hemoglobin concentration. Such studies were overall underpowered and of insufficient duration to show ...
Source: Circulation - January 29, 2020 Category: Cardiology Authors: Sharma A, Pagidipati NJ, Califf RM, McGuire DK, Green JB, Demets D, George JT, Gerstein HC, Hobbs T, Holman RR, Lawson FC, Leiter LA, Pfeffer MA, Reusch J, Riesmeyer JS, Roe MT, Rosenberg Y, Temple R, Wiviott SD, McMurray JJV, Granger CB Tags: Circulation Source Type: research

Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction.
Conclusions: Our findings suggest that transiently altering sphingolipid metabolism through AC overexpression is sufficient and necessary to induce cardioprotection post MI, thereby highlighting the therapeutic potential of AC modRNA in ischemic heart disease. PMID: 31992066 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 29, 2020 Category: Cardiology Authors: Hadas Y, Vincek AS, Youssef E, Żak MM, Chepurko E, Sultana N, Sharkar MTK, Guo N, Komargodski R, Kurian AA, Kaur K, Magadum A, Fargnoli A, Katz MG, Hossain N, Kenigsberg E, Dubois NC, Schadt E, Hajjar R, Eliyahu E, Zangi L Tags: Circulation Source Type: research

Muscling in on Resistant Hypertension.
PMID: 31986090 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Authors: Valenzuela PL, Ruilope LM, Lucia A Tags: Circulation Source Type: research

The Challenges of Observational Comparative Effectiveness Research.
PMID: 31986091 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Authors: de Lemos JA, Nallamothu BK Tags: Circulation Source Type: research

Regulatory RNAs in Heart Failure.
Abstract Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a leading cause of mortality and disability despite significant efforts to improve treatments and personalize healthcare. Heart failure is the main manifestation of cardiovascular disease and has reached epidemic proportions. Heart failure follows a loss of cardiac homeostasis, which relies on a tight regulation of gene expression. This regulation is under the control of multiple types of RNA molecules, some encoding proteins (the so-called messenger RNAs) and others lacking protein-coding potential, named noncoding RNAs. In ...
Source: Circulation - January 28, 2020 Category: Cardiology Authors: Gomes CPDC, Schroen B, Kuster GM, Robinson EL, Ford K, Squire IB, Heymans S, Martelli F, Emanueli C, Devaux Y, EU-CardioRNA COST Action (CA17129) Tags: Circulation Source Type: research

Effects of Omega-3 Fatty Acid Supplements on Arrhythmias.
PMID: 31986094 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Authors: Parish S, Mafham M, Offer A, Barton J, Wallendszus K, Stevens W, Buck G, Haynes R, Collins R, Bowman L, Armitage J, ASCEND Study Collaborative Group Tags: Circulation Source Type: research

Correction to: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Authors: PMID: 31986095 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Tags: Circulation Source Type: research

Letter by Mordi et al Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial".
Letter by Mordi et al Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial". Circulation. 2020 Jan 28;141(4):e55-e56 Authors: Mordi IR, Mohan M, Lang CC PMID: 31986096 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Authors: Mordi IR, Mohan M, Lang CC Tags: Circulation Source Type: research

Correction to: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Authors: PMID: 31986097 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Tags: Circulation Source Type: research

Response by Bergmark et al to Letter Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial".
Response by Bergmark et al to Letter Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial". Circulation. 2020 Jan 28;141(4):e57-e58 Authors: Bergmark BA, Bhatt DL, McGuire DK, Scirica BM PMID: 31986098 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 28, 2020 Category: Cardiology Authors: Bergmark BA, Bhatt DL, McGuire DK, Scirica BM Tags: Circulation Source Type: research

Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy.
Conclusions: In the largest sequenced DCM cohort yet described, we observe robust disease association with 12 genes, highlighting their importance in DCM and translating into high interpretability in diagnostic testing. The other genes analyzed here will need to be rigorously evaluated in ongoing curation efforts to determine their validity as Mendelian DCM genes but have limited value in diagnostic testing in DCM at present. This data will contribute to community gene curation efforts and will reduce erroneous and inconclusive findings in diagnostic testing. PMID: 31983221 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 27, 2020 Category: Cardiology Authors: Mazzarotto F, Tayal U, Buchan RJ, Midwinter W, Wilk A, Whiffin N, Govind R, Mazaika E, de Marvao A, Dawes TJW, Felkin LE, Ahmad M, Theotokis PI, Edwards E, Ing AY, Thomson KL, Chan LLH, Sim D, Baksi AJ, Pantazis A, Roberts AM, Watkins HC, Funke B, O'Regan Tags: Circulation Source Type: research

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Conclusions: Myosin conformations establish work-energy equipoise that is essential for life-long cellular homeostasis and heart function. Destabilization of myosin energy conserving states promotes contractile abnormalities, morphological and metabolic remodeling and adverse clinical outcomes in HCM patients. Therapeutic restabilization corrects cellular contractile and metabolic phenotypes and may limit these adverse clinical outcomes in HCM patients. PMID: 31983222 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 27, 2020 Category: Cardiology Authors: Toepfer CN, Garfinkel AC, Venturini G, Wakimoto H, Repetti G, Alamo L, Sharma A, Agarwal R, Ewoldt JF, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, Jacoby D, Michels M, Redwood CS, Watkins HC, Day SM, Staples JF, Padrón R, Chopra A, Ho CY Tags: Circulation Source Type: research

Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.
Conclusions: Dapagliflozin decreased the incidence of reported episodes of AF/AFL adverse events in high-risk patients with T2DM. This effect was consistent regardless of the patients' prior history of AF, ASCVD, or HF. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT01730534. PMID: 31983236 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 27, 2020 Category: Cardiology Authors: Zelniker TA, Bonaca MP, Furtado R, Mosenzon O, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Budaj A, Kiss RG, Padilla F, Gause-Nilsson I, Langkilde AM, Raz I, Sabatine MS, Wiviott SD Tags: Circulation Source Type: research

An International, Multicentered, EvidenceBased Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.
PMID: 31983240 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 27, 2020 Category: Cardiology Authors: Adler A, Novelli V, Amin AS, Abiusi E, Care M, Nannenberg EA, Feilotter H, Amenta S, Mazza D, Bikker H, Sturm AC, Garcia J, Ackerman MJ, Hershberger RE, Perez MV, Zareba W, Ware JS, Wilde AAM, Gollob MH Tags: Circulation Source Type: research

Correction to: Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.
Authors: PMID: 31958241 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 21, 2020 Category: Cardiology Tags: Circulation Source Type: research

The Fourth Universal Definition of Myocardial Infarction and the Emerging Importance of Myocardial Injury.
PMID: 31958242 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 21, 2020 Category: Cardiology Authors: Morrow DA Tags: Circulation Source Type: research

Response by Murakami and Riella to Letter Regarding Article, "Notch-1 Inhibition Promoted Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms".
Response by Murakami and Riella to Letter Regarding Article, "Notch-1 Inhibition Promoted Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms". Circulation. 2020 Jan 21;141(3):e37-e38 Authors: Murakami N, Riella LV PMID: 31958243 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 21, 2020 Category: Cardiology Authors: Murakami N, Riella LV Tags: Circulation Source Type: research

Letter by Wang et al Regarding Article, "Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms".
Letter by Wang et al Regarding Article, "Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms". Circulation. 2020 Jan 21;141(3):e35-e36 Authors: Wang D, Yang X, Bi K PMID: 31958244 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 21, 2020 Category: Cardiology Authors: Wang D, Yang X, Bi K Tags: Circulation Source Type: research

Cardiovascular Science India Tour: Impacting Cardiovascular Disease in South Asia.
PMID: 31958245 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 21, 2020 Category: Cardiology Authors: Kalra A, Kumbhani DJ, Hill JA Tags: Circulation Source Type: research

Opportunistic Computed Tomography Imaging for the Assessment of Fatty Muscle Fraction Predicts Outcome in Patients Undergoing Transcatheter Aortic Valve Replacement.
PMID: 31958246 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 21, 2020 Category: Cardiology Authors: Luetkens JA, Faron A, Geissler HL, Al-Kassou B, Shamekhi J, Stundl A, Sprinkart AM, Meyer C, Fimmers R, Treede H, Grube E, Nickenig G, Sinning JM, Thomas D Tags: Circulation Source Type: research

LDL-Cholesterol Lowering Strategies and Population Health - Time to Move to a Cumulative Exposure Model.
Abstract Lifetime medication burden from current approaches to LDL-cholesterol (LDL-C) lowering is reliant on small molecules requiring daily dosing with the burden of responsibility placed upon patients. Patient-related factors (risk perception, health literacy) impact adherence and persistence. Adherence to statins and ezetimibe correlate with LDL-C reduction and risk, potentially accounting for approximately 12 000 avoidable cardiovascular events per 500 000 patients annually (1). Attempts to improve adherence have had mixed results with only textmessaging reminders, community health worker-based reinforcement ...
Source: Circulation - January 20, 2020 Category: Cardiology Authors: Brandts J, Ray KK Tags: Circulation Source Type: research

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.
Conclusions: We identified the molecules bufalin and lycorine as drug candidates for therapeutic applications in cardiac fibrosis and diastolic dysfunction. PMID: 31948273 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 17, 2020 Category: Cardiology Authors: Schimmel K, Jung M, Foinquinos A, San José G, Beaumont J, Bock K, Grote-Levi L, Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F, Kreutzer FP, Ken Tags: Circulation Source Type: research

Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest.
Conclusions: We found no significant effect modification by drug administration route for amiodarone or lidocaine compared to placebo during OHCA. However, point estimates for the effects of both drugs compared to placebo were greater for the IV than IO route across all outcomes and beneficial only for IV. Given that the study was underpowered to statistically assess interactions, these findings signal the potential importance of the drug administration route during resuscitation that merits further investigation. PMID: 31941354 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Daya MR, Leroux BG, Dorian P, Rea TD, Newgard CD, Morrison LJ, Lupton JR, Menegazzi JJ, Ornato JP, Sopko G, Christenson J, Idris A, Mody P, Vilke GM, Herdeman C, Barbic D, Kudenchuk PJ, Resuscitation Outcomes Consortium Investigators Tags: Circulation Source Type: research

Orphan G-Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling.
Conclusions: Taken together, our data show that GPRC5B regulates vascular SMC tone and differentiation by negatively regulating IP signaling. PMID: 31941358 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Carvalho J, Chennupati R, Li R, Günther S, Kaur H, Zhao W, Tonack S, Kurz M, Mößlein N, Bünemann M, Offermanns S, Wettschureck N Tags: Circulation Source Type: research

Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium.
Conclusions: Failing cardiomyocytes exhibit elevated viscosity, and reducing microtubule density or detyrosination lowers viscoelastic resistance to diastolic stretch in human myocytes and myocardium. In failing myocardium, microtubules elevate stiffness over the typical working range of strains and strain rates, but exhibited diminishing effects with increasing length, consistent with an increasing contribution of the extracellular matrix and/or myofilament proteins at larger excursions. These studies indicate that a stabilized microtubule network provides a viscous impediment to diastolic stretch, particularly in HF. ...
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL Tags: Circulation Source Type: research

Variation in Ultrasound Diagnostic Thresholds for Carotid Stenosis in the United States.
Conclusions: The diagnostic threshold for carotid stenosis varies considerably. Whether or not a person is said to have moderate stenosis and enters surveillance - and whether or not they have severe stenosis and are candidates for surgery - can depend on which center performs their ultrasound. PMID: 31941366 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Columbo JA, Zwolak RM, Arous EJ, Goodney PP, Lilly MP, Welch HG Tags: Circulation Source Type: research

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis Following Myocardial Infarction.
Conclusions: Our study provides novel evidence for the primary role of neutrophil-derived alarmins (S100A8/A9) in dictating the nature of the ensuing inflammatory response following myocardial injury. Therapeutic strategies aimed at disruption of S100A8/A9 signaling or its downstream mediators (e.g. Nlrp3, IL-1β) in neutrophils suppress granulopoiesis and may improve cardiac function in ACS patients. PMID: 31941367 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, Quaife-Ryan GA, Al-Sharea A, Pernes G, Dragoljevic D, Lal H, Schroder K, Hanaoka BY, Raman C, Grant MB, Hudson JE, Smyth S, Porrello ER, Murphy AJ, Nagareddy PR Tags: Circulation Source Type: research

Time Trends in Cardiovascular Disease Mortality Across the BRICS: An Age-Period-Cohort Analysis of Key Nations with Emerging Economies Using the Global Burden of Disease Study 2017.
Conclusions: With the exception of Brazil, reductions of CVD mortality across the BRICS have been less than in North America, such that China, India and South Africa contribute an increasing proportion of global CVD deaths. Brazil's example suggests that prevention policies can both reduce the risks for younger birth cohorts and shift the risks for all age groups over time. PMID: 31941371 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Zou Z, Cini K, Dong B, Ma Y, Ma J, Burgner DP, Patton GC Tags: Circulation Source Type: research

Dysfunctional HDLs are Associated with a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested-Case Control Study.
Conclusions: Low cholesterol efflux capacity values, pro-oxidant/pro-inflammatory HDL particles, and low HDL levels of sphingosine-1-phosphate and apolipoprotein A-I were associated with increased odds of acute coronary syndrome and its manifestations in high cardiovascular risk subjects. Clinical Trial Registration: URL: http://www.controlled-trials.com Unique identifier: ISRCTN35739639. PMID: 31941372 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Soria-Florido MT, Castañer O, Lassale C, Estruch R, Salas-Salvadó J, Martínez-González MÁ, Corella D, Ros E, Arós F, Elosua R, Lapetra J, Fiol M, Alonso-Gómez A, Gómez-Gracia E, Serra-Majem L, Pintó X, Bulló M, Ruiz-Canela M, Sorlí JV, Hernáez Tags: Circulation Source Type: research

An International Multi-Center Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.
lini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ Abstract Background: Insight into type 5 long QT syndrome (LQT5) has been limited to case reports and small family series. Improved understanding of the clinical phenotype and genetic featu...
Source: Circulation - January 16, 2020 Category: Cardiology Authors: Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazz Tags: Circulation Source Type: research

Highlights From the Circulation Family of Journals.
Authors: PMID: 31928432 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Tags: Circulation Source Type: research

Correction to: Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.
Authors: PMID: 31928433 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Tags: Circulation Source Type: research

Cardio-Immuno-Oncology.
PMID: 31928434 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Zaha VG, Meijers WC, Moslehi J Tags: Circulation Source Type: research

Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome.
CONCLUSIONS: All together, our results suggest sterile inflammation as a novel paradigm to disease progression, and we identify, for the first time, monocytes as a viable candidate for targeted therapy in MVD. PMID: 31928435 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Kim AJ, Xu N, Umeyama K, Hulin A, Ponny SR, Vagnozzi RJ, Green EA, Hanson P, McManus BM, Nagashima H, Yutzey KE Tags: Circulation Source Type: research

Prevalence of Brugada Syndrome in a Large Population of Young Singaporean Men.
PMID: 31928436 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Shen X, Tan BYQ, Sia CH, Lee JSW, Dalakoti M, Wang K, Lim DYZ, Sng GGR, Lee ECY, Chow W, Kwan CKW, Wang LK, Tan BY, Lim PCY, Chua KCM, Ho KL, Lim ETS, Ching CK, Teo WS, Chua TSJ, Tan RS, Yeo TJ, Chong DTT Tags: Circulation Source Type: research

Childhood Risk Factors Contribute to Cardiovascular Events in Adults.
PMID: 31928437 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Kuehn BM Tags: Circulation Source Type: research

Letter by Mehmood Regarding Article, "Three Public Health Interventions Could Save 94 Million Lives in 25 Years: Global Impact Assessment Analysis".
Letter by Mehmood Regarding Article, "Three Public Health Interventions Could Save 94 Million Lives in 25 Years: Global Impact Assessment Analysis". Circulation. 2020 Jan 14;141(2):e3-e4 Authors: Mehmood M PMID: 31928438 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Mehmood M Tags: Circulation Source Type: research

Response by Kontis et al to Letter Regarding Article, "Three Public Health Interventions Could Save 94 Million Lives in 25 Years: Global Impact Assessment Analysis".
Response by Kontis et al to Letter Regarding Article, "Three Public Health Interventions Could Save 94 Million Lives in 25 Years: Global Impact Assessment Analysis". Circulation. 2020 Jan 14;141(2):e5 Authors: Kontis V, Cobb LK, Mathers CD, Frieden TR, Ezzati M, Danaei G PMID: 31928439 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Kontis V, Cobb LK, Mathers CD, Frieden TR, Ezzati M, Danaei G Tags: Circulation Source Type: research

Correction to: Recent Innovations, Modifications, and Evolution of ACC/AHA Clinical Practice Guidelines: An Update for Our Constituencies: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Authors: PMID: 31928440 [PubMed - in process] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Tags: Circulation Source Type: research

Racial Differences in Malignant Left Ventricular Hypertrophy and Incidence of Heart Failure: A Multi-Cohort Study.
Abstract Background: A "malignant" subphenotype of left ventricular hypertrophy (LVH) has been described, in which minimal elevations in cardiac biomarkers identify individuals with LVH at high risk for developing heart failure (HF). We tested the hypothesis that a higher prevalence of malignant LVH among blacks may contribute to racial disparities in HF risk. Methods: Participants (n=15, 710) without prevalent cardiovascular disease were pooled from three population-based cohort studies, the Atherosclerosis Risk in Communities Study (ARIC), the Dallas Heart Study (DHS), and the Multi-Ethnic Study of Ath...
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Lewis AA, Ayers CR, Selvin E, Neeland I, Ballantyne C, Nambi V, Pandey A, Powell-Wiley TM, Drazner MH, Carnethon MR, Berry JD, Seliger SL, deFilippi CR, de Lemos JA Tags: Circulation Source Type: research

Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure Overloaded Hearts.
Conclusions: The degradation of cytokine mRNA by Regnase-1 in cardiomyocytes plays an important role in restraining sterile inflammation in failing hearts and the Regnase-1-mediated pathway might be a therapeutic target to treat patients with heart failure. PMID: 31931613 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 14, 2020 Category: Cardiology Authors: Omiya S, Omori Y, Taneike M, Murakawa T, Ito J, Tanada Y, Nishida K, Yamaguchi O, Satoh T, Shah AM, Akira S, Otsu K Tags: Circulation Source Type: research

Coconut Oil and Heart Health: Fact or Fiction?
PMID: 31928069 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 13, 2020 Category: Cardiology Authors: Sacks FM Tags: Circulation Source Type: research

The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials.
Abstract Background: Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular risk factors compared with other cooking oils using data from clinical trials. Methods: We searched PubMed, SCOPUS, Cochrane Registry, and Web of Science through June 2019. We selected trials that compared the effects of coconut oil consumption with other fats that lasted at least 2 weeks. ...
Source: Circulation - January 13, 2020 Category: Cardiology Authors: Neelakantan N, Seah JYH, van Dam RM Tags: Circulation Source Type: research

Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice.
Conclusions: We demonstrate for the first time that miR-130b-3p enrichment in dysfunctional adipocyte-derived sEV, and its suppression of multiple anti-apoptotic/cardioprotective molecules in cardiomyocytes, is a novel mechanism exacerbating MI/R injury in the diabetic heart. Targeting miR-130b-3p mediated pathological communication between dysfunctional adipocytes and cardiomyocytes may be a novel strategy attenuating diabetic exacerbation of MI/R injury. PMID: 31918577 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 10, 2020 Category: Cardiology Authors: Gan L, Xie D, Liu J, Lau WB, Christopher TA, Lopez B, Zhang L, Gao E, Koch W, Ma XL, Wang Y Tags: Circulation Source Type: research

OUTSMART HF: A Randomized Controlled Trial of Routine Versus Selective Cardiac Magnetic Resonance for Patients with Non-Ischemic Heart Failure (IMAGE-HF 1B).
Conclusions: In patients with non-ischemic HF, Routine CMR does not yield more specific HF etiologies on clinical assessment. Patients with specific HF etiologies from imaging had worse outcomes whereas HF etiologies defined clinically did not. Clinical Trial Registration: URL: https://clinicaltrials.gov. Unique Identifier: NCT01281384. PMID: 31910649 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - January 8, 2020 Category: Cardiology Authors: Paterson DI, Wells G, Erthal F, Mielniczuk L, O'Meara E, White J, Connelly KA, Knuuti J, Rajda M, Laine M, Chow BJW, Kandolin R, Chen L, Dick A, Dennie C, Garrard L, Ezekowitz J, Beanlands R, Chan KL, IMAGE-HF 1B investigators Tags: Circulation Source Type: research