Single Nuclei Sequencing Reveals Novel Insights into the Regulation of Cellular Signatures in Children with Dilated Cardiomyopathy
Conclusions: Novel insights into the cellular transcriptomes of hearts from pediatric DCM patients provide remarkable age-dependent changes in the expression patterns of fibroblast and cardiomyocyte genes with less fibrotic but enriched pro-regenerative signatures in infants.PMID:33618539 | DOI:10.1161/CIRCULATIONAHA.120.051391 (Source: Circulation)
Source: Circulation - February 23, 2021 Category: Cardiology Authors: Luka Nicin Wesley T Abplanalp Anne Sch änzer Anke Sprengel David John Hannah Mellentin Lukas Tombor Matthias Keuper Evelyn Ullrich Karin Klingel Reinhard B Dettmeyer Jedrzej Hoffmann Hakan Akintuerk Christian Jux Dietmar Schranz Andreas M Zeiher Stefan R Source Type: research

Cerebral Embolic Protection and Outcomes of Transcatheter Aortic Valve Replacement: Results from the TVT Registry
Conclusions: In this nationally-representative observational study, we did not find an association between EPD use for TAVR and in-hospital stroke in our primary IV analysis, and found only a modestly lower risk of in-hospital stroke in our secondary propensity-weighted analysis. These findings provide a strong basis for large-scale RCTs to test whether EPDs provide meaningful clinical benefit for patients undergoing TAVR.PMID:33619968 | DOI:10.1161/CIRCULATIONAHA.120.052874 (Source: Circulation)
Source: Circulation - February 23, 2021 Category: Cardiology Authors: Neel M Butala Raj Makkar Eric A Secemsky Dianne Gallup Guillaume Marquis-Gravel Andrzej S Kosinski Sreekanth Vemulapalli Javier A Valle Steven M Bradley Tarun Chakravarty Robert W Yeh David J Cohen Source Type: research

Long-Term Association of Air Pollution and Hospital Admissions Among Medicare Participants Using a Doubly Robust Additive Model
Circulation. 2021 Feb 22. doi: 10.1161/CIRCULATIONAHA.120.050252. Online ahead of print.NO ABSTRACTPMID:33611922 | DOI:10.1161/CIRCULATIONAHA.120.050252 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Mahdieh Danesh Yazdi Yan Wang Qian Di Yaguang Wei Weeberb J Requia Liuhua Shi Matthew Benjamin Sabath Francesca Dominici Brent A Coull John S Evans Petros Koutrakis Joel D Schwartz Source Type: research

Response by Horiuchi et al to Letter Regarding Article, "Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction"
Circulation. 2021 Feb 23;143(8):e252-e253. doi: 10.1161/CIRCULATIONAHA.120.051634. Epub 2021 Feb 22.NO ABSTRACTPMID:33617307 | DOI:10.1161/CIRCULATIONAHA.120.051634 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Yu Horiuchi Nicholas Wettersten Alan Maisel Source Type: research

Highlights From the Circulation Family of Journals
Circulation. 2021 Feb 23;143(8):852-856. doi: 10.1161/CIRCULATIONAHA.121.053936. Epub 2021 Feb 22.NO ABSTRACTPMID:33617308 | DOI:10.1161/CIRCULATIONAHA.121.053936 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Source Type: research

Mending Broken Hearts: A New Treatment Paradigm for Immune Checkpoint Inhibitor-Induced Myocarditis
Circulation. 2021 Feb 23;143(8):767-769. doi: 10.1161/CIRCULATIONAHA.120.052307. Epub 2021 Feb 22.NO ABSTRACTPMID:33617309 | DOI:10.1161/CIRCULATIONAHA.120.052307 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Bonnie L Bermas Vlad G Zaha Source Type: research

Letter by Putot et al Regarding Article, "Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction"
Circulation. 2021 Feb 23;143(8):e250-e251. doi: 10.1161/CIRCULATIONAHA.120.051103. Epub 2021 Feb 22.NO ABSTRACTPMID:33617310 | DOI:10.1161/CIRCULATIONAHA.120.051103 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Alain Putot Yves Cottin Marianne Zeller Source Type: research

Screening for Fabry Disease in Male Patients With Arrhythmia Requiring a Pacemaker or an Implantable Cardioverter-Defibrillator
Circulation. 2021 Feb 23;143(8):872-874. doi: 10.1161/CIRCULATIONAHA.120.051400. Epub 2021 Feb 22.NO ABSTRACTPMID:33617311 | DOI:10.1161/CIRCULATIONAHA.120.051400 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Dimitri Hemelsoet Jan De Keyser Frederic Van Heuverswyn Rik Willems Hans Vandekerckhove Antoine Bondue Carlo de Asmundis Johan Saenen Stefaan Van de Walle Pascal Godart Christoph Kampmann Hedwig Stepman Bruce Poppe Wim Terryn Source Type: research

A Case of Presyncope After Transcatheter Aortic Valve Replacement
Circulation. 2021 Feb 23;143(8):857-861. doi: 10.1161/CIRCULATIONAHA.120.049693. Epub 2021 Feb 22.NO ABSTRACTPMID:33617312 | DOI:10.1161/CIRCULATIONAHA.120.049693 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Virginia Workman John K Forrest Alan Enriquez Source Type: research

When You Hear Hoofbeats, Look for Horses, Not Zebras
Circulation. 2021 Feb 23;143(8):862-864. doi: 10.1161/CIRCULATIONAHA.120.052468. Epub 2021 Feb 22.NO ABSTRACTPMID:33617313 | DOI:10.1161/CIRCULATIONAHA.120.052468 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Dursun Aras Ozcan Ozeke Serkan Topaloglu Source Type: research

Why Choose Between SGLT2 Inhibitors and GLP1-RA When You Can Use Both?: The Time to Act Is Now
Circulation. 2021 Feb 23;143(8):780-782. doi: 10.1161/CIRCULATIONAHA.120.053058. Epub 2021 Feb 22.NO ABSTRACTPMID:33617314 | DOI:10.1161/CIRCULATIONAHA.120.053058 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: Alice Y Y Cheng Source Type: research

Bending the Curve in Cardiovascular Disease Mortality: Bethesda + 40 and Beyond
This report summarizes the relevant research, policy, and practice opportunities discussed at the symposium.PMID:33617315 | DOI:10.1161/CIRCULATIONAHA.120.046501 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Authors: David Calvin Goff Sadiya Sana Khan Donald Lloyd-Jones Donna K Arnett Mercedes R Carnethon Darwin R Labarthe Matthew Shane Loop Russell V Luepker Michael V McConnell George A Mensah Mahasin S Mujahid Martin Enrique O'Flaherty Dorairaj Prabhakaran V éroniq Source Type: research

Correction to: Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling
Circulation. 2021 Feb 23;143(8):e745. doi: 10.1161/CIR.0000000000000951. Epub 2021 Feb 22.NO ABSTRACTPMID:33617316 | DOI:10.1161/CIR.0000000000000951 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Source Type: research

Correction to: Risk of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Addition of SGLT2 Inhibitors Versus Sulfonylureas to Baseline GLP-1RA Therapy
Circulation. 2021 Feb 23;143(8):e744. doi: 10.1161/CIR.0000000000000964. Epub 2021 Feb 22.NO ABSTRACTPMID:33617317 | DOI:10.1161/CIR.0000000000000964 (Source: Circulation)
Source: Circulation - February 22, 2021 Category: Cardiology Source Type: research

Short Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart
Circulation. 2021 Feb 19. doi: 10.1161/CIRCULATIONAHA.120.052671. Online ahead of print.ABSTRACTBackground: The failing heart is energy-starved with impaired oxidation of long chain fatty acids (LCFA) at the level of reduced carnitine palmitoyltransferase 1 (CPT1) activity at the outer mitochondrial membrane. Recent work shows elevated ketone oxidation in failing hearts as an alternate carbon source for oxidative ATP generation. We hypothesized that another short chain carbon source, short chain fatty acids (SCFA) that bypass CPT1, could similarly support energy production in failing hearts. Methods: Cardiac hypertrophy an...
Source: Circulation - February 19, 2021 Category: Cardiology Authors: Andrew N Carley Santosh K Maurya Matthew Fasano Yang Wang Craig H Selzman Stavros G Drakos E Douglas Lewandowski Source Type: research

The Association of Serum Aldosterone and Plasma Renin Activity with Ambulatory Blood Pressure in African Americans: The Jackson Heart Study
Circulation. 2021 Feb 19. doi: 10.1161/CIRCULATIONAHA.120.050896. Online ahead of print.ABSTRACTBackground: The renin-angiotensin-aldosterone system (RAAS) is an important driver of BP but the association of the RAAS with ambulatory blood pressure (ABP) and ABPM phenotypes among African Americans (AA) has not been assessed. Methods: ABP and ABPM phenotypes were assessed in 912 Jackson Heart Study participants with aldosterone and plasma renin activity (PRA). Multivariable linear and logistic regression analysis were used to analyze the association of aldosterone, and PRA with clinic, awake and asleep systolic blood pressur...
Source: Circulation - February 19, 2021 Category: Cardiology Authors: Joshua J Joseph Neal K Pohlman Songzhu Zhao David Kline Guy Brock Justin B Echouffo-Tcheugui Mario Sims Valery S Effoe Wen-Chih Wu Rita R Kalyani Gary S Wand Bjorn Kluwe Willa A Hsueh Marwah Abdalla Daichi Shimbo Sherita H Golden Source Type: research

Short Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart.
Abstract Background: The failing heart is energy-starved with impaired oxidation of long chain fatty acids (LCFA) at the level of reduced carnitine palmitoyltransferase 1 (CPT1) activity at the outer mitochondrial membrane. Recent work shows elevated ketone oxidation in failing hearts as an alternate carbon source for oxidative ATP generation. We hypothesized that another short chain carbon source, short chain fatty acids (SCFA) that bypass CPT1, could similarly support energy production in failing hearts. Methods: Cardiac hypertrophy and dysfunction was induced in rats by transverse-aortic constriction (TAC). 14 ...
Source: Circulation - February 19, 2021 Category: Cardiology Authors: Carley AN, Maurya SK, Fasano M, Wang Y, Selzman CH, Drakos SG, Lewandowski ED Tags: Circulation Source Type: research

The Association of Serum Aldosterone and Plasma Renin Activity with Ambulatory Blood Pressure in African Americans: The Jackson Heart Study.
Abstract Background: The renin-angiotensin-aldosterone system (RAAS) is an important driver of BP but the association of the RAAS with ambulatory blood pressure (ABP) and ABPM phenotypes among African Americans (AA) has not been assessed. Methods: ABP and ABPM phenotypes were assessed in 912 Jackson Heart Study participants with aldosterone and plasma renin activity (PRA). Multivariable linear and logistic regression analysis were used to analyze the association of aldosterone, and PRA with clinic, awake and asleep systolic blood pressure (SBP) and diastolic blood pressure (DBP) and ABPM phenotypes, adjusting for ...
Source: Circulation - February 19, 2021 Category: Cardiology Authors: Joseph JJ, Pohlman NK, Zhao S, Kline D, Brock G, Echouffo-Tcheugui JB, Sims M, Effoe VS, Wu WC, Kalyani RR, Wand GS, Kluwe B, Hsueh WA, Abdalla M, Shimbo D, Golden SH Tags: Circulation Source Type: research

Excessive O - GlcNAcylation Causes Heart Failure and Sudden Death.
Conclusions: Our data provide evidence that excessive O-GlcNAcylation causes cardiomyopathy, at least in part, due to defective energetics. Enhanced OGA activity is well tolerated and attenuation of O-GlcNAcylation is beneficial against pressure overload induced pathologic remodeling and heart failure. These findings suggest attenuation of excessive O-GlcNAcylation may represent a novel therapeutic approach for cardiomyopathy. PMID: 33593071 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 17, 2021 Category: Cardiology Authors: Umapathi P, Banerjee PS, Zachara NE, Abrol N, Wang Q, Mesubi OO, Luczak ED, Wu Y, Granger JM, Wei AC, Reyes Gaido OE, Florea L, Talbot CC, Hart GW, Anderson ME Tags: Circulation Source Type: research

Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead Electrocardiogram and Help Identify Those at Risk of AF-Related Stroke.
rty CM PMID: 33588584 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Raghunath S, Pfeifer JM, Ulloa-Cerna AE, Nemani A, Carbonati T, Jing L, vanMaanen DP, Hartzel DN, Ruhl JA, Lagerman BF, Rocha DB, Stoudt NJ, Schneider G, Johnson KW, Zimmerman N, Leader JB, Kirchner HL, Griessenauer CJ, Hafez A, Good CW, Fornwalt BK, Hagg Tags: Circulation Source Type: research

MicroRNA Biophysically Modulates Cardiac Action Potential via Directly Binding to Ion Channel.
Conclusions: Our study reveals a novel evolutionarily-conserved biophysical action of endogenous miRs in modulating cardiac electrophysiology. Our discovery of miRs' biophysical modulation provides a more comprehensive understanding of ion-channel dysregulation and may provide new insights into the pathogenesis of cardiac arrhythmias. PMID: 33590773 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Yang D, Wan X, Dennis AT, Bektik E, Wang Z, Costa MGS, Fagnen C, Vénien-Bryan C, Xu X, Gratz DH, Hund TJ, Mohler PJ, Laurita KR, Deschênes I, Fu JD Tags: Circulation Source Type: research

Rising Prepregnancy Hypertension, Preeclampsia Disparities Raise Alarm.
PMID: 33587653 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Kuehn BM Tags: Circulation Source Type: research

Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials: Insights From the TIMI trials.
Abstract BACKGROUND: Women are underrepresented across cardiovascular clinical trials. Whether women are more likely than men to prematurely discontinue study drug or withdraw consent once enrolled in a clinical trial is unknown. METHODS: Eleven phase 3/4 TIMI (Thrombolysis in Myocardial Infarction) trials were included (135 879 men and 51 812 women [28%]). The association between sex and premature study drug discontinuation and withdrawal of consent were examined by multivariable logistic regression after adjusting for potential confounders in each individual trial and combining the individual point estimate...
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Lau ES, Braunwald E, Morrow DA, Giugliano RP, Antman EM, Gibson CM, Scirica BM, Bohula EA, Wiviott SD, Bhatt DL, Bonaca MP, Cannon CP, Im K, Guo J, Sabatine MS, O'Donoghue ML Tags: Circulation Source Type: research

Sex Differences in Blood Pressure Associations With Cardiovascular Outcomes.
PMID: 33587655 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Ji H, Niiranen TJ, Rader F, Henglin M, Kim A, Ebinger JE, Claggett B, Merz CNB, Cheng S Tags: Circulation Source Type: research

Sudden Cardiac Arrest in Young Women.
ger; PMID: 33587656 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Weizman O, Sharifzadehgan A, Bougouin W, Narayanan K, Tence N, Dumas F, Waldmann V, Lamhaut L, Jost D, Wahbi K, Varenne O, Garcia R, Karam N, Cariou A, Jouven X, Marijon E, Paris-SDEC Investigators† Tags: Circulation Source Type: research

Sex-Related Differences in Cardiac Channelopathies: Implications for Clinical Practice.
Abstract Sex-related differences in prevalence, clinical presentation, and outcome of cardiac channelopathies are increasingly recognized, despite their autosomal transmission and hence equal genetic predisposition among sexes. In congenital long-QT syndrome, adult women carry a greater risk for Torsades de pointes and sudden cardiac death than do men. In contrast, Brugada syndrome is observed predominantly in adult men, with a considerably higher risk of arrhythmic sudden cardiac death in adult men than in women. In both conditions, the risk for arrhythmias varies with age. Sex-associated differences appear less ...
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Asatryan B, Yee L, Ben-Haim Y, Dobner S, Servatius H, Roten L, Tanner H, Crotti L, Skinner JR, Remme CA, Chevalier P, Medeiros-Domingo A, Behr ER, Reichlin T, Odening KE, Krahn AD Tags: Circulation Source Type: research

Transcatheter Mitral Valve Edge-to-Edge Repair for Secondary Mitral Regurgitation: Why Sex Matters.
PMID: 33587658 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Shah SV, Bavry AA, Kumbhani DJ Tags: Circulation Source Type: research

Comparison of the Efficacy and Safety Outcomes of Edoxaban in 8040 Women Versus 13 065 Men With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial.
This study aimed to examine the efficacy and safety profile of edoxaban in women versus men. METHODS: The ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) randomly assigned 21 105 patients (8040 women) with atrial fibrillation and CHADS2 score ≥2 either to a higher-dose edoxaban regimen, a lower-dose edoxaban regimen, or warfarin. The primary end points of the trial were the composite of stroke or systemic embolic events (efficacy), and International Society on Thrombosis and Haemostasis-defined major bleeding (...
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Zelniker TA, Ardissino M, Andreotti F, O'Donoghue ML, Yin O, Park JG, Murphy SA, Ruff CT, Lanz HJ, Antman EM, Braunwald E, Giugliano RP, Merlini PA Tags: Circulation Source Type: research

Cardiac Remodeling During Pregnancy With Metabolic Syndrome: Prologue of Pathological Remodeling.
CONCLUSIONS: These results suggest that preexisting MetS could disrupt physiological hypertrophy during pregnancy to produce pathological cardiac remodeling that could predispose the heart to chronic disorders. PMID: 33587660 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Yang Y, Kurian J, Schena G, Johnson J, Kubo H, Travers JG, Kang C, Lucchese AM, Eaton DM, Lv M, Li N, Leynes LG, Yu D, Yang F, McKinsey TA, Kishore R, Khan M, Mohsin S, Houser SR Tags: Circulation Source Type: research

Fifth Annual Go Red for Women Issue.
PMID: 33587661 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Al-Khatib SM, Hill JA, Bozkurt B Tags: Circulation Source Type: research

Regional Heterogeneity in the Coronary Vascular Response in Women With Chest Pain and Nonobstructive Coronary Artery Disease.
PMID: 33587662 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Elharram M, Hillier E, Hawkins S, Mikami Y, Heydari B, Merchant N, White JA, Anderson T, Friedrich MG, Pilote L Tags: Circulation Source Type: research

Temporal Trends in the Proportion of Women Physician Speakers at Major Cardiovascular Conferences.
PMID: 33587663 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Yong CM, Balasubramanian S, Douglas PS, Agarwal P, Birgersdotter-Green U, Gummidipundi S, Batchelor W, Duvernoy CS, Harrington RA, Mehran R Tags: Circulation Source Type: research

Adherence to Study Drugs: A Matter of Sex?
PMID: 33587664 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Sederholm Lawesson S, Swahn E, Alfredsson J Tags: Circulation Source Type: research

Efficacy of Neprilysin Inhibition in Women With HFpEF: Beyond Phenotypes and Natriuretic Peptides.
PMID: 33587665 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Cooper LB, Cotugno A, deFilippi C Tags: Circulation Source Type: research

Maternal Stroke: A Call for Action.
Abstract Maternal mortality rates have been steadily increasing in the United States, and cardiovascular mortality is the leading cause of death among pregnant and postpartum women. Maternal stroke accounts for a significant burden of cardiovascular mortality. Data suggest that rates of maternal stroke have been increasing in recent years. Advancing maternal age at the time of birth and the increasing prevalence of traditional cardiovascular risk factors, and other risk factors, as well, such as hypertensive disorders of pregnancy, migraine, and infections, may contribute to increased rates of maternal stroke. In ...
Source: Circulation - February 16, 2021 Category: Cardiology Authors: Elgendy IY, Bukhari S, Barakat AF, Pepine CJ, Lindley KJ, Miller EC, American College of Cardiology Cardiovascular Disease in Women Committee Tags: Circulation Source Type: research

Correction to: Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association.
Authors: PMID: 33587667 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 16, 2021 Category: Cardiology Tags: Circulation Source Type: research

TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing.
Conclusions: We demonstrate that circRNAs formed from the TTN transcript are essential for normal splicing of key muscle genes by enabling splice regulators RBM20 and SRSF10. This shows that the TTN transcript also has regulatory roles, besides its well-known signaling and structural function. In addition, we demonstrate that the specific sequence created by the backsplice junction of these circRNAs has important functions. This highlights the existence of functionally important sequences that cannot be recognized as such in the human genome, but provides a yet unrecognized source for functional sequence variation. PM...
Source: Circulation - February 15, 2021 Category: Cardiology Authors: Tijsen AJ, Cócera Ortega L, Reckman YJ, Zhang X, van der Made I, Aufiero S, Li J, Kamps SC, van den Bout A, Devalla HD, van Spaendonck-Zwarts K, Engelhardt S, Gepstein L, Ware JS, Pinto YM Tags: Circulation Source Type: research

Blood Pressure Effects of Sodium Reduction: Dose-Response Meta-Analysis of Experimental Studies.
PMID: 33586450 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 15, 2021 Category: Cardiology Authors: Filippini T, Malavolti M, Whelton PK, Naska A, Orsini N, Vinceti M Tags: Circulation Source Type: research

Multiple Biomarker Approach to Risk Stratification in COVID-19.
PMID: 33587646 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 15, 2021 Category: Cardiology Authors: Smilowitz NR, Nguy V, Aphinyanaphongs Y, Newman JD, Xia Y, Reynolds HR, Hochman JS, Fishman GI, Berger JS Tags: Circulation Source Type: research

Effects of a 2-Year Primary Care Lifestyle Intervention on Cardiometabolic Risk Factors: A Cluster-Randomized Trial.
oup PMID: 33557578 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Höchsmann C, Dorling JL, Martin CK, Newton RL, Apolzan JW, Myers CA, Denstel KD, Mire EF, Johnson WD, Zhang D, Arnold CL, Davis TC, Fonseca V, Lavie CJ, Price-Haywood EG, Katzmarzyk PT, PROPEL Research Group Tags: Circulation Source Type: research

Letter by Alkhalil and Kuzemczak Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52  816 Patients From 12 Randomized Trials".
Letter by Alkhalil and Kuzemczak Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials". Circulation. 2021 Feb 09;143(6):e234-e235 Authors: Alkhalil M, Kuzemczak M PMID: 33555915 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Alkhalil M, Kuzemczak M Tags: Circulation Source Type: research

Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention: A North American Perspective: 2021 Update.
Abstract A growing number of patients undergoing percutaneous coronary intervention (PCI) with stent implantation also have atrial fibrillation. This poses challenges for their optimal antithrombotic management because patients with atrial fibrillation undergoing PCI require oral anticoagulation for the prevention of cardiac thromboembolism and dual antiplatelet therapy for the prevention of coronary thrombotic complications. The combination of oral anticoagulation and dual antiplatelet therapy substantially increases the risk of bleeding. Over the last decade, a series of North American Consensus Statements on th...
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Angiolillo DJ, Bhatt DL, Cannon CP, Eikelboom JW, Gibson CM, Goodman SG, Granger CB, Holmes DR, Lopes RD, Mehran R, Moliterno DJ, Price MJ, Saw J, Tanguay JF, Faxon DP Tags: Circulation Source Type: research

Response by Navarese et al to Letters Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52  816 Patients From 12 Randomized Trials".
Response by Navarese et al to Letters Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials". Circulation. 2021 Feb 09;143(6):e236-e237 Authors: Navarese EP, Khan SU, James S PMID: 33555917 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Navarese EP, Khan SU, James S Tags: Circulation Source Type: research

Bizarre Downsloping ST Segment Elevation Challenge.
PMID: 33555919 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Karabinos I, Kostaki P, Panagopoulos Z Tags: Circulation Source Type: research

Healthy Coronary Endothelial Cells, Happy Cardiomyocytes.
PMID: 33555920 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Wang Y, Ma X Tags: Circulation Source Type: research

Letter by Kessler et al Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52  816 Patients From 12 Randomized Trials".
Letter by Kessler et al Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials". Circulation. 2021 Feb 09;143(6):e230-e231 Authors: Kessler T, Cassese S, Kastrati A PMID: 33555921 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Kessler T, Cassese S, Kastrati A Tags: Circulation Source Type: research

Exposure to Cardiology as a Strategy to Increase the Number of Black Men in Medicine.
PMID: 33555922 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Nadamuni M, Minniefield NE, Okorodudu DO Tags: Circulation Source Type: research

Letter by Ferracane et al Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52  816 Patients From 12 Randomized Trials".
Letter by Ferracane et al Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials". Circulation. 2021 Feb 09;143(6):e232-e233 Authors: Ferracane E, Bartoli L, Messori A PMID: 33555923 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Ferracane E, Bartoli L, Messori A Tags: Circulation Source Type: research

Biostatistics Versus Pathophysiology.
PMID: 33555924 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Authors: Cohn JN Tags: Circulation Source Type: research

Correction to: COVID-19 Myocardial Pathology Evaluation in Athletes with Cardiac Magnetic Resonance (COMPETE CMR).
Authors: PMID: 33555925 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - February 9, 2021 Category: Cardiology Tags: Circulation Source Type: research