Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth
CONCLUSIONS: Cardiac sEVs, specifically cMSC-sEVs from post-MI hearts, carry multiple protumorigenic factors. Uptake of cMSC-sEVs by cancer cells accelerates tumor growth. Treatment with spironolactone significantly reduces accelerated tumor growth after MI. Our results provide new insight into the mechanism connecting post-MI LVD to cancer and propose a translational option to mitigate this deadly association.PMID:38487879 | DOI:10.1161/CIRCULATIONAHA.123.066911 (Source: Circulation)
Source: Circulation - March 15, 2024 Category: Cardiology Authors: Tal Caller Itai Rotem Olga Shaihov-Teper Daria Lendengolts Yeshai Schary Ruty Shai Efrat Glick-Saar Dan Dominissini Menachem Motiei Idan Katzir Rachela Popovtzer Merav Nahmoud Alex Boomgarden Crislyn D'Souza-Schorey Nili Naftali-Shani Jonathan Leor Source Type: research

Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth
CONCLUSIONS: Cardiac sEVs, specifically cMSC-sEVs from post-MI hearts, carry multiple protumorigenic factors. Uptake of cMSC-sEVs by cancer cells accelerates tumor growth. Treatment with spironolactone significantly reduces accelerated tumor growth after MI. Our results provide new insight into the mechanism connecting post-MI LVD to cancer and propose a translational option to mitigate this deadly association.PMID:38487879 | DOI:10.1161/CIRCULATIONAHA.123.066911 (Source: Circulation)
Source: Circulation - March 15, 2024 Category: Cardiology Authors: Tal Caller Itai Rotem Olga Shaihov-Teper Daria Lendengolts Yeshai Schary Ruty Shai Efrat Glick-Saar Dan Dominissini Menachem Motiei Idan Katzir Rachela Popovtzer Merav Nahmoud Alex Boomgarden Crislyn D'Souza-Schorey Nili Naftali-Shani Jonathan Leor Source Type: research

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials
CONCLUSIONS: In patients with left main disease considered equally suitable for PCI or CABG and with largely low to intermediate SYNTAX scores, diabetes was associated with higher rates of death and cardiovascular events through 5 years. Compared with CABG, PCI resulted in no difference in the risk of death, a lower risk of early stroke regardless of diabetes status, and a higher risk of spontaneous MI and repeat coronary revascularization, with larger late absolute excess risks in patients with diabetes.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT01205776, NCT0146651, NCT00422968, and NCT0011...
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Prakriti Gaba Joseph F Sabik Sabina A Murphy Andrea Bellavia Patrick T O'Gara Peter K Smith Patrick W Serruys A Pieter Kappetein Seung-Jung Park Duk-Woo Park Evald H Christiansen Niels R Holm Per H Nielsen Marc S Sabatine Gregg W Stone Brian A Bergmark Source Type: research

Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association
Circulation. 2024 Mar 11. doi: 10.1161/CIR.0000000000001220. Online ahead of print.ABSTRACTHematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications and provides guidance for the cardiovascular management throughout transplantation. Hematopoietic stem cell transplantation consists of 4 phases: pretra...
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Salim S Hayek Vlad G Zaha Carmel Bogle Anita Deswal Amelia Langston Seth Rotz Alexi Vasbinder Eric Yang Tochukwu Okwuosa American Heart Association Cardio-Oncology Committee of the Council on Clinical Cardiology and Council on Genomic and Precision Medici Source Type: research

Abnormal Progenitor Cell Differentiation and Cardiomyocyte Proliferation in Hypoplastic Right Heart Syndrome
Circulation. 2024 Mar 12;149(11):888-891. doi: 10.1161/CIRCULATIONAHA.123.064213. Epub 2024 Mar 11.NO ABSTRACTPMID:38466780 | PMC:PMC10936550 | DOI:10.1161/CIRCULATIONAHA.123.064213 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Yang Yu Cankun Wang Shiqiao Ye Zhaohui Xu Hui Lin Karen Texter Vasudha Shukla Samir Ghadiali Qin Ma Vidu Garg Ming-Tao Zhao Source Type: research

Correction to: 2023 Scientific Sessions Abstract 18890
Circulation. 2024 Mar 12;149(11):e957. doi: 10.1161/CIR.0000000000001227. Epub 2024 Mar 11.NO ABSTRACTPMID:38466781 | DOI:10.1161/CIR.0000000000001227 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Source Type: research

Response by Zimmermann et al to Letter Regarding Article, "Fractional Flow Reserve-Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial"
Circulation. 2024 Mar 12;149(11):896. doi: 10.1161/CIRCULATIONAHA.123.068238. Epub 2024 Mar 11.NO ABSTRACTPMID:38466782 | DOI:10.1161/CIRCULATIONAHA.123.068238 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Frederik M Zimmermann Victoria Y Ding William F Fearon Source Type: research

Letter by Rodriguez et al Regarding Article, "Fractional Flow Reserve-Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial"
Circulation. 2024 Mar 12;149(11):894-895. doi: 10.1161/CIRCULATIONAHA.123.067446. Epub 2024 Mar 11.NO ABSTRACTPMID:38466783 | DOI:10.1161/CIRCULATIONAHA.123.067446 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Alfredo E Rodriguez Carlos Fernandez-Pereira Juan Mieres Source Type: research

Correction to: 2023 Scientific Sessions Abstract 18918
Circulation. 2024 Mar 12;149(11):e958. doi: 10.1161/CIR.0000000000001229. Epub 2024 Mar 11.NO ABSTRACTPMID:38466784 | DOI:10.1161/CIR.0000000000001229 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Source Type: research

End-Stage Heart Failure in Cardiac Sarcoidosis
Circulation. 2024 Mar 12;149(11):885-887. doi: 10.1161/CIRCULATIONAHA.123.066962. Epub 2024 Mar 11.NO ABSTRACTPMID:38466785 | DOI:10.1161/CIRCULATIONAHA.123.066962 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Diana Velikanova Pauli P öyhönen Jukka Lehtonen Piia Simonen Valtteri Uusitalo Tapani Vihinen Kari Kaikkonen Petri Haataja Tuomas Kerola Tuomas T Rissanen Ville Veps äläinen Aleksi Alatalo P äivi Pietilä-Effati Markku Kupari Source Type: research

Correction to: 2023 Scientific Sessions Abstract 18987
Circulation. 2024 Mar 12;149(11):e959. doi: 10.1161/CIR.0000000000001228. Epub 2024 Mar 11.NO ABSTRACTPMID:38466786 | DOI:10.1161/CIR.0000000000001228 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Source Type: research

Are Recommendations That Favor Other Agents Over Angiotensin-Converting Enzyme Inhibitors in Africans With Hypertension Justified?
Circulation. 2024 Mar 12;149(11):804-806. doi: 10.1161/CIRCULATIONAHA.123.065887. Epub 2024 Mar 11.NO ABSTRACTPMID:38466787 | DOI:10.1161/CIRCULATIONAHA.123.065887 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Jonathan G Peter Ntobeko A B Ntusi Mpiko Ntsekhe Source Type: research

Antiarrhythmic Drug Therapy: Where Do We Go From Here?
Circulation. 2024 Mar 12;149(11):801-803. doi: 10.1161/CIRCULATIONAHA.123.066989. Epub 2024 Mar 11.NO ABSTRACTPMID:38466788 | DOI:10.1161/CIRCULATIONAHA.123.066989 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Peter R Kowey Gerald V Naccarelli Source Type: research

Letter by Heuts et al Regarding Article, "Fractional Flow Reserve-Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial"
Circulation. 2024 Mar 12;149(11):892-893. doi: 10.1161/CIRCULATIONAHA.123.066934. Epub 2024 Mar 11.NO ABSTRACTPMID:38466789 | DOI:10.1161/CIRCULATIONAHA.123.066934 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Samuel Heuts Patrick O Myers Matthias Siepe Source Type: research

Dual (Ischemic and Nonischemic) Cardiomyopathy: A Wolf in Sheep's Clothing
Circulation. 2024 Mar 12;149(11):822-824. doi: 10.1161/CIRCULATIONAHA.123.068090. Epub 2024 Mar 11.NO ABSTRACTPMID:38466790 | DOI:10.1161/CIRCULATIONAHA.123.068090 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: Gladys Junc à Victoria Delgado Source Type: research