A Patient-Level Meta-Analysis: The End of the Era of Direct Oral Anticoagulant Developmental Trials in Patients With Atrial Fibrillation?
Circulation. 2022 Jan 25;145(4):256-258. doi: 10.1161/CIRCULATIONAHA.121.058159. Epub 2022 Jan 24.NO ABSTRACTPMID:35073174 | DOI:10.1161/CIRCULATIONAHA.121.058159 (Source: Circulation)
Source: Circulation - January 24, 2022 Category: Cardiology Authors: Shinya Goto Shinichi Goto Source Type: research

Preventing Anthracycline-Induced Cardiotoxicity Using Functional Genomics and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circulation. 2022 Jan 25;145(4):295-298. doi: 10.1161/CIRCULATIONAHA.121.058128. Epub 2022 Jan 24.NO ABSTRACTPMID:35073175 | DOI:10.1161/CIRCULATIONAHA.121.058128 (Source: Circulation)
Source: Circulation - January 24, 2022 Category: Cardiology Authors: Valentina Lo Sardo Timothy J Kamp Source Type: research

Highlights From the < em > Circulation < /em > Family of Journals
Circulation. 2022 Jan 25;145(4):309-314. doi: 10.1161/CIRCULATIONAHA.121.058903. Epub 2022 Jan 24.NO ABSTRACTPMID:35073176 | DOI:10.1161/CIRCULATIONAHA.121.058903 (Source: Circulation)
Source: Circulation - January 24, 2022 Category: Cardiology Source Type: research

Letter by Costantine et al Regarding Article, "Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia"
Circulation. 2022 Jan 25;145(4):e115-e116. doi: 10.1161/CIRCULATIONAHA.121.056728. Epub 2022 Jan 24.NO ABSTRACTPMID:35073177 | DOI:10.1161/CIRCULATIONAHA.121.056728 (Source: Circulation)
Source: Circulation - January 24, 2022 Category: Cardiology Authors: Maged M Costantine Kirsten Lawrence-Cleary Georges Saade Ronald J Wapner Source Type: research

The Clinical Impact of Device Lead-Associated Tricuspid Regurgitation: Need for a Multidisciplinary Approach
Circulation. 2022 Jan 25;145(4):239-241. doi: 10.1161/CIRCULATIONAHA.121.055019. Epub 2022 Jan 24.NO ABSTRACTPMID:35073178 | DOI:10.1161/CIRCULATIONAHA.121.055019 (Source: Circulation)
Source: Circulation - January 24, 2022 Category: Cardiology Authors: Aviral Vij Clifford J Kavinsky Source Type: research

Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart
Circulation. 2022 Jan 25;145(4):315-318. doi: 10.1161/CIRCULATIONAHA.121.055690. Epub 2022 Jan 24.NO ABSTRACTPMID:35073179 | DOI:10.1161/CIRCULATIONAHA.121.055690 (Source: Circulation)
Source: Circulation - January 24, 2022 Category: Cardiology Authors: Liang Chen Kui Hua Ningning Zhang Jingyu Wang Jian Meng Zhenliang Hu Haoxiang Gao Fanhong Li Yang Chen Jie Ren Liyang Liu Qiming Zhou Jin Gu Jiangping Song Xuegong Zhang Shengshou Hu Source Type: research

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure
Conclusions: This study provides mechanistic insights into the process of forced cardiomyocyte proliferation and advances the clinical feasibility of this approach by minimizing the oncogenic potential of the cell cycle factors thanks to the use of a novel transient and cardiomyocyte-specific viral construct.PMID:35061545 | DOI:10.1161/CIRCULATIONAHA.121.057641 (Source: Circulation)
Source: Circulation - January 21, 2022 Category: Cardiology Authors: Riham R E Abouleisa Abou Bakr M Salama Qinghui Ou Xian-Liang Tang Mitesh Solanki Yiru Guo Yibing Nong Lindsey McNally Pawel K Lorkiewicz Kamal M Kassem Brooke M Ahern Krishna Choudhary Reuben Thomas Yu Huang Hamzah R Juhardeen Aisha Siddique Zainab Ifthik Source Type: research

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure
Conclusions: This study provides mechanistic insights into the process of forced cardiomyocyte proliferation and advances the clinical feasibility of this approach by minimizing the oncogenic potential of the cell cycle factors thanks to the use of a novel transient and cardiomyocyte-specific viral construct.PMID:35061545 | DOI:10.1161/CIRCULATIONAHA.121.057641 (Source: Circulation)
Source: Circulation - January 21, 2022 Category: Cardiology Authors: Riham R E Abouleisa Abou Bakr M Salama Qinghui Ou Xian-Liang Tang Mitesh Solanki Yiru Guo Yibing Nong Lindsey McNally Pawel K Lorkiewicz Kamal M Kassem Brooke M Ahern Krishna Choudhary Reuben Thomas Yu Huang Hamzah R Juhardeen Aisha Siddique Zainab Ifthik Source Type: research

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure
Conclusions: This study provides mechanistic insights into the process of forced cardiomyocyte proliferation and advances the clinical feasibility of this approach by minimizing the oncogenic potential of the cell cycle factors thanks to the use of a novel transient and cardiomyocyte-specific viral construct.PMID:35061545 | DOI:10.1161/CIRCULATIONAHA.121.057641 (Source: Circulation)
Source: Circulation - January 21, 2022 Category: Cardiology Authors: Riham R E Abouleisa Abou Bakr M Salama Qinghui Ou Xian-Liang Tang Mitesh Solanki Yiru Guo Yibing Nong Lindsey McNally Pawel K Lorkiewicz Kamal M Kassem Brooke M Ahern Krishna Choudhary Reuben Thomas Yu Huang Hamzah R Juhardeen Aisha Siddique Zainab Ifthik Source Type: research

Circulating Metabolome and White Matter Hyperintensities in Females and Males
Circulation. 2022 Jan 20. doi: 10.1161/CIRCULATIONAHA.121.056892. Online ahead of print.ABSTRACTBackground: White matter hyperintensities (WMH) are identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness; WMH are a major risk factor of stroke, dementia, and death. Currently, there are no large-scale studies testing associations between WMH and circulating metabolites. Methods: We studied up to 9,290 individuals (50.7% females, average age 61 years) from 15 populations of 8 community-based cohorts. WMH volume was quantified from T2-weighted or fluid-attenuated inversion-recover...
Source: Circulation - January 20, 2022 Category: Cardiology Authors: Eeva Sliz Jean Shin Shahzad Ahmad Dylan M Williams Stefan Frenzel Friederike Gau ß Sarah E Harris Ann-Kristin Henning Maria Del C Valdes Hernandez Yi-Han Hu Beatriz Jim énez Muralidharan Sargurupremraj Carole Sudre Ruiqi Wang Katharina Wittfeld Qiong Ya Source Type: research

Association Between Endovascular Therapy Time to Treatment and Outcomes in Patients with Basilar Artery Occlusion
CONCLUSIONS: Among patients receiving EVT for BAO, faster treatment from symptom onset was associated with improved outcomes. These findings support efforts to achieve rapid treatment with EVT for those with BAO.PMID:35050693 | DOI:10.1161/CIRCULATIONAHA.121.056554 (Source: Circulation)
Source: Circulation - January 20, 2022 Category: Cardiology Authors: Raed A Joundi Jie-Lena Sun Ying Xian Brooke Alhanti Raul G Nogueira Deepak L Bhatt Gregg C Fonarow Jeffrey Saver Lee H Schwamm Eric E Smith Source Type: research

Cost Effectiveness of Coronary-Artery Bypass Surgery versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial
Conclusions: In STICH patients with ischemic cardiomyopathy and reduced left ventricular function, CABG was economically attractive relative to medical therapy at current benchmarks for value in the United States.PMID:35044802 | DOI:10.1161/CIRCULATIONAHA.121.056276 (Source: Circulation)
Source: Circulation - January 19, 2022 Category: Cardiology Authors: Derek S Chew Patricia A Cowper Hussein Al-Khalidi Kevin J Anstrom Melanie R Daniels Linda Davidson-Ray Yanhong Li Robert E Michler Julio A Panza Ileana L Pi ña Jean L Rouleau Eric J Velazquez Daniel B Mark STICH Investigators Source Type: research

Cost Effectiveness of Coronary-Artery Bypass Surgery versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial
Conclusions: In STICH patients with ischemic cardiomyopathy and reduced left ventricular function, CABG was economically attractive relative to medical therapy at current benchmarks for value in the United States.PMID:35044802 | DOI:10.1161/CIRCULATIONAHA.121.056276 (Source: Circulation)
Source: Circulation - January 19, 2022 Category: Cardiology Authors: Derek S Chew Patricia A Cowper Hussein Al-Khalidi Kevin J Anstrom Melanie R Daniels Linda Davidson-Ray Yanhong Li Robert E Michler Julio A Panza Ileana L Pi ña Jean L Rouleau Eric J Velazquez Daniel B Mark STICH Investigators Source Type: research

E-Cigarettes and Cardiopulmonary Health: Review for Clinicians
Circulation. 2022 Jan 18;145(3):219-232. doi: 10.1161/CIRCULATIONAHA.121.056777. Epub 2022 Jan 18.ABSTRACTElectronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. Recent clinical trials suggest that e-cigarette use with counseling may be effective in reducing cigarette use but not nicotine dependence. However, meta-analyses of observational studie...
Source: Circulation - January 18, 2022 Category: Cardiology Authors: Evan W Neczypor Matthew J Mears Arunava Ghosh M Flori Sassano Richard J Gumina Loren E Wold Robert Tarran Source Type: research

E-Cigarettes and Cardiopulmonary Health: Review for Clinicians
Circulation. 2022 Jan 18;145(3):219-232. doi: 10.1161/CIRCULATIONAHA.121.056777. Epub 2022 Jan 18.ABSTRACTElectronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became commercially available without evidence regarding their risks, long-term safety, or utility in smoking cessation. Recent clinical trials suggest that e-cigarette use with counseling may be effective in reducing cigarette use but not nicotine dependence. However, meta-analyses of observational studie...
Source: Circulation - January 18, 2022 Category: Cardiology Authors: Evan W Neczypor Matthew J Mears Arunava Ghosh M Flori Sassano Richard J Gumina Loren E Wold Robert Tarran Source Type: research

Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox
Conclusions: The study delineates temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism at multi-omics levels. The obesity paradox is attributable to increased cardiac lipids supply from adipose lipolysis in the fasting cycle due to systemic insulin resistance and adiposity. Cardiac molecular chronotypes may be involved in human DCM. Myocardial bioenergetics downstream of Rev-erb may be a chronotherapy target in treating heart failure and DCM.PMID:35034472 | DOI:10.1161/CIRCULATIONAHA.121.056076 (Source: Circulation)
Source: Circulation - January 17, 2022 Category: Cardiology Authors: Shiyang Song Chih-Liang Tien Hao Cui Paul Basil Ningxia Zhu Yingyun Gong Wenbo Li Hui Li Qiying Fan Jong Min Choi Weijia Luo Yanfeng Xue Rui Cao Wenjun Zhou Andrea R Ortiz Brittany Stork Vatsala Mundra Nagireddy Putluri Brian York Maoping Chu Jiang Chang Source Type: research

Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox
Conclusions: The study delineates temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism at multi-omics levels. The obesity paradox is attributable to increased cardiac lipids supply from adipose lipolysis in the fasting cycle due to systemic insulin resistance and adiposity. Cardiac molecular chronotypes may be involved in human DCM. Myocardial bioenergetics downstream of Rev-erb may be a chronotherapy target in treating heart failure and DCM.PMID:35034472 | DOI:10.1161/CIRCULATIONAHA.121.056076 (Source: Circulation)
Source: Circulation - January 17, 2022 Category: Cardiology Authors: Shiyang Song Chih-Liang Tien Hao Cui Paul Basil Ningxia Zhu Yingyun Gong Wenbo Li Hui Li Qiying Fan Jong Min Choi Weijia Luo Yanfeng Xue Rui Cao Wenjun Zhou Andrea R Ortiz Brittany Stork Vatsala Mundra Nagireddy Putluri Brian York Maoping Chu Jiang Chang Source Type: research

Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk fa...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research

Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough
Circulation. 2022 Jan 11;145(2):94-96. doi: 10.1161/CIRCULATIONAHA.121.055877. Epub 2022 Jan 10.NO ABSTRACTPMID:35007158 | DOI:10.1161/CIRCULATIONAHA.121.055877 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Jordana B Cohen Tammy M Brady Source Type: research

Bidirectional Changes in Myocardial < sup > 18 < /sup > F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading
Circulation. 2022 Jan 11;145(2):151-154. doi: 10.1161/CIRCULATIONAHA.121.056278. Epub 2022 Jan 10.NO ABSTRACTPMID:35007159 | DOI:10.1161/CIRCULATIONAHA.121.056278 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Tiberiu A Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M Subramaniam Chao Xing Kathryn A Morton Stavros G Drakos Vlad G Zaha Hesham A Sadek Source Type: research

Celebrating The Next Generation of Cardiovascular Investigators
Circulation. 2022 Jan 11;145(2):91-93. doi: 10.1161/CIRCULATIONAHA.121.058678. Epub 2022 Jan 10.NO ABSTRACTPMID:35007160 | DOI:10.1161/CIRCULATIONAHA.121.058678 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: James A de Lemos Darren K McGuire Joseph A Hill Source Type: research

The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data
Circulation. 2022 Jan 11;145(2):107-109. doi: 10.1161/CIRCULATIONAHA.121.057931. Epub 2022 Jan 10.NO ABSTRACTPMID:35007161 | DOI:10.1161/CIRCULATIONAHA.121.057931 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Seng Chan You Harlan M Krumholz Source Type: research

Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk fa...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research

Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough
Circulation. 2022 Jan 11;145(2):94-96. doi: 10.1161/CIRCULATIONAHA.121.055877. Epub 2022 Jan 10.NO ABSTRACTPMID:35007158 | DOI:10.1161/CIRCULATIONAHA.121.055877 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Jordana B Cohen Tammy M Brady Source Type: research

Bidirectional Changes in Myocardial < sup > 18 < /sup > F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading
Circulation. 2022 Jan 11;145(2):151-154. doi: 10.1161/CIRCULATIONAHA.121.056278. Epub 2022 Jan 10.NO ABSTRACTPMID:35007159 | DOI:10.1161/CIRCULATIONAHA.121.056278 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Tiberiu A Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M Subramaniam Chao Xing Kathryn A Morton Stavros G Drakos Vlad G Zaha Hesham A Sadek Source Type: research

Celebrating The Next Generation of Cardiovascular Investigators
Circulation. 2022 Jan 11;145(2):91-93. doi: 10.1161/CIRCULATIONAHA.121.058678. Epub 2022 Jan 10.NO ABSTRACTPMID:35007160 | DOI:10.1161/CIRCULATIONAHA.121.058678 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: James A de Lemos Darren K McGuire Joseph A Hill Source Type: research

The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data
Circulation. 2022 Jan 11;145(2):107-109. doi: 10.1161/CIRCULATIONAHA.121.057931. Epub 2022 Jan 10.NO ABSTRACTPMID:35007161 | DOI:10.1161/CIRCULATIONAHA.121.057931 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Seng Chan You Harlan M Krumholz Source Type: research

Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk fa...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research

Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough
Circulation. 2022 Jan 11;145(2):94-96. doi: 10.1161/CIRCULATIONAHA.121.055877. Epub 2022 Jan 10.NO ABSTRACTPMID:35007158 | DOI:10.1161/CIRCULATIONAHA.121.055877 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Jordana B Cohen Tammy M Brady Source Type: research

Bidirectional Changes in Myocardial < sup > 18 < /sup > F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading
Circulation. 2022 Jan 11;145(2):151-154. doi: 10.1161/CIRCULATIONAHA.121.056278. Epub 2022 Jan 10.NO ABSTRACTPMID:35007159 | DOI:10.1161/CIRCULATIONAHA.121.056278 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Tiberiu A Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M Subramaniam Chao Xing Kathryn A Morton Stavros G Drakos Vlad G Zaha Hesham A Sadek Source Type: research

Celebrating The Next Generation of Cardiovascular Investigators
Circulation. 2022 Jan 11;145(2):91-93. doi: 10.1161/CIRCULATIONAHA.121.058678. Epub 2022 Jan 10.NO ABSTRACTPMID:35007160 | DOI:10.1161/CIRCULATIONAHA.121.058678 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: James A de Lemos Darren K McGuire Joseph A Hill Source Type: research

The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data
Circulation. 2022 Jan 11;145(2):107-109. doi: 10.1161/CIRCULATIONAHA.121.057931. Epub 2022 Jan 10.NO ABSTRACTPMID:35007161 | DOI:10.1161/CIRCULATIONAHA.121.057931 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Seng Chan You Harlan M Krumholz Source Type: research

Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk fa...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research

Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough
Circulation. 2022 Jan 11;145(2):94-96. doi: 10.1161/CIRCULATIONAHA.121.055877. Epub 2022 Jan 10.NO ABSTRACTPMID:35007158 | DOI:10.1161/CIRCULATIONAHA.121.055877 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Jordana B Cohen Tammy M Brady Source Type: research

Bidirectional Changes in Myocardial < sup > 18 < /sup > F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading
Circulation. 2022 Jan 11;145(2):151-154. doi: 10.1161/CIRCULATIONAHA.121.056278. Epub 2022 Jan 10.NO ABSTRACTPMID:35007159 | DOI:10.1161/CIRCULATIONAHA.121.056278 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Tiberiu A Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M Subramaniam Chao Xing Kathryn A Morton Stavros G Drakos Vlad G Zaha Hesham A Sadek Source Type: research

Celebrating The Next Generation of Cardiovascular Investigators
Circulation. 2022 Jan 11;145(2):91-93. doi: 10.1161/CIRCULATIONAHA.121.058678. Epub 2022 Jan 10.NO ABSTRACTPMID:35007160 | DOI:10.1161/CIRCULATIONAHA.121.058678 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: James A de Lemos Darren K McGuire Joseph A Hill Source Type: research

The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data
Circulation. 2022 Jan 11;145(2):107-109. doi: 10.1161/CIRCULATIONAHA.121.057931. Epub 2022 Jan 10.NO ABSTRACTPMID:35007161 | DOI:10.1161/CIRCULATIONAHA.121.057931 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Seng Chan You Harlan M Krumholz Source Type: research

Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk fa...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research

Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough
Circulation. 2022 Jan 11;145(2):94-96. doi: 10.1161/CIRCULATIONAHA.121.055877. Epub 2022 Jan 10.NO ABSTRACTPMID:35007158 | DOI:10.1161/CIRCULATIONAHA.121.055877 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Jordana B Cohen Tammy M Brady Source Type: research

Bidirectional Changes in Myocardial < sup > 18 < /sup > F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading
Circulation. 2022 Jan 11;145(2):151-154. doi: 10.1161/CIRCULATIONAHA.121.056278. Epub 2022 Jan 10.NO ABSTRACTPMID:35007159 | DOI:10.1161/CIRCULATIONAHA.121.056278 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Tiberiu A Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M Subramaniam Chao Xing Kathryn A Morton Stavros G Drakos Vlad G Zaha Hesham A Sadek Source Type: research

Celebrating The Next Generation of Cardiovascular Investigators
Circulation. 2022 Jan 11;145(2):91-93. doi: 10.1161/CIRCULATIONAHA.121.058678. Epub 2022 Jan 10.NO ABSTRACTPMID:35007160 | DOI:10.1161/CIRCULATIONAHA.121.058678 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: James A de Lemos Darren K McGuire Joseph A Hill Source Type: research

The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data
Circulation. 2022 Jan 11;145(2):107-109. doi: 10.1161/CIRCULATIONAHA.121.057931. Epub 2022 Jan 10.NO ABSTRACTPMID:35007161 | DOI:10.1161/CIRCULATIONAHA.121.057931 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Seng Chan You Harlan M Krumholz Source Type: research

Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk fa...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108 (Source: Circulation)
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research

Common Ancestry-specific Ion Channel Variants Predispose to Drug-induced Arrhythmias
Circulation. 2022 Jan 7. doi: 10.1161/CIRCULATIONAHA.121.054883. Online ahead of print.ABSTRACTBackground: Multiple reports associate the cardiac sodium channel gene (SCN5A) variants S1103Y and R1193Q with type 3 congenital long QT syndrome (LQTS) and drug-induced LQTS. These variants are, however, too common in ancestral populations to be highly arrhythmogenic at baseline: S1103Y allele frequency is 8.1% in Africans and R1193Q 6.1% in East Asians. R1193Q is known to increase late sodium current (INa-L) in cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) but the role of these variants in modulating rep...
Source: Circulation - January 7, 2022 Category: Cardiology Authors: Yuko Wada Tao Yang Christian M Shaffer Laura L Daniel Andrew M Glazer Giovanni E Davogustto Brandon D Lowery Eric Farber-Eger Quinn S Wells Dan M Roden Source Type: research