Evaluation and Management of Aortic Stenosis in Chronic Kidney Disease: A Scientific Statement From the American Heart Association
Circulation. 2021 May 13:CIR0000000000000979. doi: 10.1161/CIR.0000000000000979. Online ahead of print.ABSTRACTAortic stenosis with concomitant chronic kidney disease (CKD) represents a clinical challenge. Aortic stenosis is more prevalent and progresses more rapidly and unpredictably in CKD, and the presence of CKD is associated with worse short-term and long-term outcomes after aortic valve replacement. Because patients with advanced CKD and end-stage kidney disease have been excluded from randomized trials, clinicians need to make complex management decisions in this population that are based on retrospective and observ...
Source: Circulation - May 13, 2021 Category: Cardiology Authors: Gautam R Shroff Sripal Bangalore Nicole M Bhave Tara I Chang Santiago Garcia Roy O Mathew Janani Rangaswami Julien Ternacle Vinod H Thourani Philippe Pibarot American Heart Association Council on the Kidney in Cardiovascular Disease and Stroke Council Source Type: research

The Effect of Neprilysin Inhibition on Left Ventricular Remodeling in Patients with Asymptomatic Left Ventricular Systolic Dysfunction Late After Myocardial Infarction
Conclusions: In patients with asymptomatic LVSD following MI, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan. Clinical Trial Registration: URL: https://www.clinicaltrials.gov Unique identifier: NCT03552575.PMID:33983794 | DOI:10.1161/CIRCULATIONAHA.121.054892 (Source: Circulation)
Source: Circulation - May 13, 2021 Category: Cardiology Authors: Kieran F Docherty Ross T Campbell Katriona J M Brooksbank John G Dreisbach Paul Forsyth Rosemary L Godeseth Tracey Hopkins Alice M Jackson Matthew M Y Lee Alex McConnachie Giles Roditi Iain B Squire Bethany Stanley Paul Welsh Pardeep S Jhund Mark C Petrie Source Type: research

2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report
Circulation. 2021 May 11:CIR0000000000000963. doi: 10.1161/CIR.0000000000000963. Online ahead of print.NO ABSTRACTPMID:33974449 | DOI:10.1161/CIR.0000000000000963 (Source: Circulation)
Source: Circulation - May 11, 2021 Category: Cardiology Source Type: research

2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report
Circulation. 2021 May 11:CIR0000000000000963. doi: 10.1161/CIR.0000000000000963. Online ahead of print.NO ABSTRACTPMID:33974449 | DOI:10.1161/CIR.0000000000000963 (Source: Circulation)
Source: Circulation - May 11, 2021 Category: Cardiology Source Type: research

2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report
Circulation. 2021 May 11:CIR0000000000000963. doi: 10.1161/CIR.0000000000000963. Online ahead of print.NO ABSTRACTPMID:33974449 | DOI:10.1161/CIR.0000000000000963 (Source: Circulation)
Source: Circulation - May 11, 2021 Category: Cardiology Source Type: research

Cardiovascular Risk Factor Trajectories Since Childhood and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study
Circulation. 2021 May 10. doi: 10.1161/CIRCULATIONAHA.120.052358. Online ahead of print.NO ABSTRACTPMID:33966448 | DOI:10.1161/CIRCULATIONAHA.120.052358 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Juuso O Hakala Katja Pahkala Markus Juonala Pia Salo Mika K ähönen Nina Hutri-K ähönen Terho Lehtim äki Tomi P Laitinen Eero Jokinen Leena Taittonen P äivi Tossavainen Jorma S A Viikari Olli T Raitakari Suvi P Rovio Source Type: research

Preterm Delivery and Long-Term Risk of Stroke in Women: A National Cohort and Cosibling Study
Circulation. 2021 May 10. doi: 10.1161/CIRCULATIONAHA.120.052268. Online ahead of print.NO ABSTRACTPMID:33966449 | DOI:10.1161/CIRCULATIONAHA.120.052268 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Casey Crump Jan Sundquist Kristina Sundquist Source Type: research

Morbidly Obese Patients With Symptomatic Atrial Fibrillation: Why Are We Holding Back on Bariatric Surgery?
Circulation. 2021 May 11;143(19):1838-1840. doi: 10.1161/CIRCULATIONAHA.120.051527. Epub 2021 May 10.NO ABSTRACTPMID:33970672 | DOI:10.1161/CIRCULATIONAHA.120.051527 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Mohita Singh Jose Joglar Source Type: research

Letter by Ji and Zheng Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis"
Circulation. 2021 May 11;143(19):e917-e918. doi: 10.1161/CIRCULATIONAHA.120.051731. Epub 2021 May 10.NO ABSTRACTPMID:33970673 | DOI:10.1161/CIRCULATIONAHA.120.051731 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Lei Ji Yuehong Zheng Source Type: research

Letter by Wu et al Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis"
Circulation. 2021 May 11;143(19):e919-e920. doi: 10.1161/CIRCULATIONAHA.120.053212. Epub 2021 May 10.NO ABSTRACTPMID:33970674 | DOI:10.1161/CIRCULATIONAHA.120.053212 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Zhenguo Wu Wencheng Zhang Jianmin Yang Source Type: research

Cardiovascular Evaluation After COVID-19 in 137 Collegiate Athletes: Results of an Algorithm-Guided Screening
Circulation. 2021 May 11;143(19):1926-1928. doi: 10.1161/CIRCULATIONAHA.121.053982. Epub 2021 May 10.NO ABSTRACTPMID:33970675 | DOI:10.1161/CIRCULATIONAHA.121.053982 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Benjamin S Hendrickson Ryan E Stephens James V Chang Jacob M Amburn Lindsey L Pierotti Jessica L Johnson John C Hyden Jason N Johnson Ranjit R Philip Source Type: research

Response by Jeon and Oh to Letter Regarding Article, "Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis"
Circulation. 2021 May 11;143(19):e921-e922. doi: 10.1161/CIRCULATIONAHA.121.053671. Epub 2021 May 10.NO ABSTRACTPMID:33970676 | DOI:10.1161/CIRCULATIONAHA.121.053671 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Sejin Jeon Goo Taeg Oh Source Type: research

HDAC Inhibition in the Heart: Erasing Hidden Fibrosis
Circulation. 2021 May 11;143(19):1891-1893. doi: 10.1161/CIRCULATIONAHA.121.054262. Epub 2021 May 10.NO ABSTRACTPMID:33970677 | DOI:10.1161/CIRCULATIONAHA.121.054262 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Thomas G Gillette Source Type: research

Cardiovascular Risk Factor Trajectories Since Childhood and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study
Circulation. 2021 May 10. doi: 10.1161/CIRCULATIONAHA.120.052358. Online ahead of print.NO ABSTRACTPMID:33966448 | DOI:10.1161/CIRCULATIONAHA.120.052358 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Juuso O Hakala Katja Pahkala Markus Juonala Pia Salo Mika K ähönen Nina Hutri-K ähönen Terho Lehtim äki Tomi P Laitinen Eero Jokinen Leena Taittonen P äivi Tossavainen Jorma S A Viikari Olli T Raitakari Suvi P Rovio Source Type: research

Preterm Delivery and Long-Term Risk of Stroke in Women: A National Cohort and Cosibling Study
Circulation. 2021 May 10. doi: 10.1161/CIRCULATIONAHA.120.052268. Online ahead of print.NO ABSTRACTPMID:33966449 | DOI:10.1161/CIRCULATIONAHA.120.052268 (Source: Circulation)
Source: Circulation - May 10, 2021 Category: Cardiology Authors: Casey Crump Jan Sundquist Kristina Sundquist Source Type: research

Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction
Conclusions: We have demonstrated that an enhanced potency of the CCND2OECMs promoted myocyte proliferation in both grafts and the recipient tissue in a large mammal acute myocardial infarction (AMI) model. These results suggest that the CCND2OECMs transplantation may be a potential therapeutic strategy for the repair of infarcted hearts.PMID:33951921 | DOI:10.1161/CIRCULATIONAHA.120.049497 (Source: Circulation)
Source: Circulation - May 6, 2021 Category: Cardiology Authors: Meng Zhao Yuji Nakada Yuhua Wei Weihua Bian Yuxin Chu Anton V Borovjagin Min Xie Wuqiang Zhu Thanh Nguyen Yang Zhou Vahid Serpooshan Gregory P Walcott Jianyi Zhang Source Type: research

Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction
Conclusions: We have demonstrated that an enhanced potency of the CCND2OECMs promoted myocyte proliferation in both grafts and the recipient tissue in a large mammal acute myocardial infarction (AMI) model. These results suggest that the CCND2OECMs transplantation may be a potential therapeutic strategy for the repair of infarcted hearts.PMID:33951921 | DOI:10.1161/CIRCULATIONAHA.120.049497 (Source: Circulation)
Source: Circulation - May 6, 2021 Category: Cardiology Authors: Meng Zhao Yuji Nakada Yuhua Wei Weihua Bian Yuxin Chu Anton V Borovjagin Min Xie Wuqiang Zhu Thanh Nguyen Yang Zhou Vahid Serpooshan Gregory P Walcott Jianyi Zhang Source Type: research

Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction
Conclusions: We have demonstrated that an enhanced potency of the CCND2OECMs promoted myocyte proliferation in both grafts and the recipient tissue in a large mammal acute myocardial infarction (AMI) model. These results suggest that the CCND2OECMs transplantation may be a potential therapeutic strategy for the repair of infarcted hearts.PMID:33951921 | DOI:10.1161/CIRCULATIONAHA.120.049497 (Source: Circulation)
Source: Circulation - May 6, 2021 Category: Cardiology Authors: Meng Zhao Yuji Nakada Yuhua Wei Weihua Bian Yuxin Chu Anton V Borovjagin Min Xie Wuqiang Zhu Thanh Nguyen Yang Zhou Vahid Serpooshan Gregory P Walcott Jianyi Zhang Source Type: research

A Composite Metric for Benchmarking Site Performance in TAVR: Results from the STS/ACC TVT Registry
Conclusions: There are substantial variations in the quality of TAVR care received in the United States, and 11% of sites were identified as providing care below the average level of performance. Further study is necessary to determine structural, process-related, and technical factors associated with high- and low-performing sites.PMID:33947202 | DOI:10.1161/CIRCULATIONAHA.120.051456 (Source: Circulation)
Source: Circulation - May 5, 2021 Category: Cardiology Authors: Nimesh D Desai Sean M O'Brien David J Cohen John Carroll Sreekanth Vemulapalli Suzanne V Arnold John K Forrest Vinod H Thourani Ajay J Kirtane Brian O'Neill Pratik Manandhar David M Shahian Vinay Badhwar Joseph E Bavaria Source Type: research

An Evidence-Based Assessment of Genes in Dilated Cardiomyopathy
Conclusions: In the curation of 51 genes, 19 had high evidence (12 definitive/strong; seven moderate). Notably, these 19 genes only explain a minority of cases, leaving the remainder of DCM genetic architecture incompletely addressed. Clinical genetic testing panels include most high evidence genes, however genes lacking robust evidence are also commonly included. We recommend that high evidence DCM genes be used for clinical practice and to exercise caution when interpreting variants in variable evidence DCM genes.PMID:33947203 | DOI:10.1161/CIRCULATIONAHA.120.053033 (Source: Circulation)
Source: Circulation - May 5, 2021 Category: Cardiology Authors: Elizabeth Jordan Laiken Peterson Tomohiko Ai Babken Asatryan Lucas Bronicki Emily Brown Rudy Celeghin Matthew Edwards Judy Fan Jodie Ingles Cynthia A James Olga Jarinova Renee Johnson Daniel P Judge Najim Lahrouchi Ronald H Lekanne Deprez R Thomas Lumbers Source Type: research

A Composite Metric for Benchmarking Site Performance in TAVR: Results from the STS/ACC TVT Registry
Conclusions: There are substantial variations in the quality of TAVR care received in the United States, and 11% of sites were identified as providing care below the average level of performance. Further study is necessary to determine structural, process-related, and technical factors associated with high- and low-performing sites.PMID:33947202 | DOI:10.1161/CIRCULATIONAHA.120.051456 (Source: Circulation)
Source: Circulation - May 5, 2021 Category: Cardiology Authors: Nimesh D Desai Sean M O'Brien David J Cohen John Carroll Sreekanth Vemulapalli Suzanne V Arnold John K Forrest Vinod H Thourani Ajay J Kirtane Brian O'Neill Pratik Manandhar David M Shahian Vinay Badhwar Joseph E Bavaria Source Type: research

An Evidence-Based Assessment of Genes in Dilated Cardiomyopathy
Conclusions: In the curation of 51 genes, 19 had high evidence (12 definitive/strong; seven moderate). Notably, these 19 genes only explain a minority of cases, leaving the remainder of DCM genetic architecture incompletely addressed. Clinical genetic testing panels include most high evidence genes, however genes lacking robust evidence are also commonly included. We recommend that high evidence DCM genes be used for clinical practice and to exercise caution when interpreting variants in variable evidence DCM genes.PMID:33947203 | DOI:10.1161/CIRCULATIONAHA.120.053033 (Source: Circulation)
Source: Circulation - May 5, 2021 Category: Cardiology Authors: Elizabeth Jordan Laiken Peterson Tomohiko Ai Babken Asatryan Lucas Bronicki Emily Brown Rudy Celeghin Matthew Edwards Judy Fan Jodie Ingles Cynthia A James Olga Jarinova Renee Johnson Daniel P Judge Najim Lahrouchi Ronald H Lekanne Deprez R Thomas Lumbers Source Type: research

Are SGLT2 Inhibitors New Hypertension Drugs?
Circulation. 2021 May 4;143(18):1750-1753. doi: 10.1161/CIRCULATIONAHA.121.053709. Epub 2021 May 3.NO ABSTRACTPMID:33939525 | DOI:10.1161/CIRCULATIONAHA.121.053709 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Kazuomi Kario Keith C Ferdinand Wanpen Vongpatanasin Source Type: research

Letter by Ferrero and Chessa Regarding Article, "Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry"
Circulation. 2021 May 4;143(18):e898-e899. doi: 10.1161/CIRCULATIONAHA.120.052619. Epub 2021 May 3.NO ABSTRACTPMID:33939526 | DOI:10.1161/CIRCULATIONAHA.120.052619 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Paolo Ferrero Massimo Chessa Source Type: research

A Return to Normal Is Not Good Enough
Circulation. 2021 May 4;143(18):e893-e897. doi: 10.1161/CIRCULATIONAHA.121.054920. Epub 2021 May 3.NO ABSTRACTPMID:33939527 | PMC:PMC8088781 | DOI:10.1161/CIRCULATIONAHA.121.054920 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Mitchell S V Elkind Robert A Harrington Donald M Lloyd-Jones Source Type: research

A "Carousel" ECG Confusion
Circulation. 2021 May 4;143(18):1824-1827. doi: 10.1161/CIRCULATIONAHA.121.054672. Epub 2021 May 3.NO ABSTRACTPMID:33939528 | DOI:10.1161/CIRCULATIONAHA.121.054672 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Ruben K A Tapia-Orihuela Oswaldo J Guti érrez Freddy Del-Carpio Munoz Source Type: research

Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism: A Multinational Prospective Real-Life Study (the RELAX-PE Study)
Circulation. 2021 May 4;143(18):1828-1830. doi: 10.1161/CIRCULATIONAHA.120.052780. Epub 2021 May 3.NO ABSTRACTPMID:33939529 | DOI:10.1161/CIRCULATIONAHA.120.052780 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Helia Robert-Ebadi Philippe Robin Olivier Hugli Franck Verschuren Albert Trinh-Duc Pierre-Marie Roy Jeannot Schmidt Thierry Fumeaux Guy Meyer Daniel Hayoz Pierre-Nicolas Carron Pierre-Yves Salaun Fran çois Sarasin Olivier Rutschmann Gr égoire Le Gal Mar Source Type: research

Response by Waldmann et al to Letter Regarding Article, "Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry"
Circulation. 2021 May 4;143(18):e900-e901. doi: 10.1161/CIRCULATIONAHA.121.053670. Epub 2021 May 3.NO ABSTRACTPMID:33939530 | DOI:10.1161/CIRCULATIONAHA.121.053670 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Victor Waldmann Nicolas Combes Kumar Narayanan Eloi Marijon Source Type: research

Statins Do More Than Lower Cholesterol-Depending on What You Eat?
Circulation. 2021 May 4;143(18):1793-1796. doi: 10.1161/CIRCULATIONAHA.121.054183. Epub 2021 May 3.NO ABSTRACTPMID:33939531 | DOI:10.1161/CIRCULATIONAHA.121.054183 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Thomas Eschenhagen Ulrich Laufs Source Type: research

Are SGLT2 Inhibitors New Hypertension Drugs?
Circulation. 2021 May 4;143(18):1750-1753. doi: 10.1161/CIRCULATIONAHA.121.053709. Epub 2021 May 3.NO ABSTRACTPMID:33939525 | DOI:10.1161/CIRCULATIONAHA.121.053709 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Kazuomi Kario Keith C Ferdinand Wanpen Vongpatanasin Source Type: research

Letter by Ferrero and Chessa Regarding Article, "Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry"
Circulation. 2021 May 4;143(18):e898-e899. doi: 10.1161/CIRCULATIONAHA.120.052619. Epub 2021 May 3.NO ABSTRACTPMID:33939526 | DOI:10.1161/CIRCULATIONAHA.120.052619 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Paolo Ferrero Massimo Chessa Source Type: research

A Return to Normal Is Not Good Enough
Circulation. 2021 May 4;143(18):e893-e897. doi: 10.1161/CIRCULATIONAHA.121.054920. Epub 2021 May 3.NO ABSTRACTPMID:33939527 | DOI:10.1161/CIRCULATIONAHA.121.054920 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Mitchell S V Elkind Robert A Harrington Donald M Lloyd-Jones Source Type: research

A "Carousel" ECG Confusion
Circulation. 2021 May 4;143(18):1824-1827. doi: 10.1161/CIRCULATIONAHA.121.054672. Epub 2021 May 3.NO ABSTRACTPMID:33939528 | DOI:10.1161/CIRCULATIONAHA.121.054672 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Ruben K A Tapia-Orihuela Oswaldo J Guti érrez Freddy Del-Carpio Munoz Source Type: research

Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism: A Multinational Prospective Real-Life Study (the RELAX-PE Study)
Circulation. 2021 May 4;143(18):1828-1830. doi: 10.1161/CIRCULATIONAHA.120.052780. Epub 2021 May 3.NO ABSTRACTPMID:33939529 | DOI:10.1161/CIRCULATIONAHA.120.052780 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Helia Robert-Ebadi Philippe Robin Olivier Hugli Franck Verschuren Albert Trinh-Duc Pierre-Marie Roy Jeannot Schmidt Thierry Fumeaux Guy Meyer Daniel Hayoz Pierre-Nicolas Carron Pierre-Yves Salaun Fran çois Sarasin Olivier Rutschmann Gr égoire Le Gal Mar Source Type: research

Response by Waldmann et al to Letter Regarding Article, "Long-Term Follow-Up of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry"
Circulation. 2021 May 4;143(18):e900-e901. doi: 10.1161/CIRCULATIONAHA.121.053670. Epub 2021 May 3.NO ABSTRACTPMID:33939530 | DOI:10.1161/CIRCULATIONAHA.121.053670 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Victor Waldmann Nicolas Combes Kumar Narayanan Eloi Marijon Source Type: research

Statins Do More Than Lower Cholesterol-Depending on What You Eat?
Circulation. 2021 May 4;143(18):1793-1796. doi: 10.1161/CIRCULATIONAHA.121.054183. Epub 2021 May 3.NO ABSTRACTPMID:33939531 | DOI:10.1161/CIRCULATIONAHA.121.054183 (Source: Circulation)
Source: Circulation - May 3, 2021 Category: Cardiology Authors: Thomas Eschenhagen Ulrich Laufs Source Type: research

Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 - 2016
Conclusions: US adult cardiovascular spending increased by>$100 billion from 1996 to 2016. Policies tailored to control service price and intensity and preferentially reimburse higher quality care could help counteract future spending increases due to population aging and growth.PMID:33926203 | DOI:10.1161/CIRCULATIONAHA.120.053216 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Maxwell Birger Alexander S Kaldjian Gregory A Roth Andrew E Moran Joseph L Dieleman Brandon K Bellows Source Type: research

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Conclusions: DAPT decreases the risk of recurrent stroke and composite events compared with monotherapy. DAPT increases the risk of major hemorrhage, except if the treatment is limited to 30 days and does not include the combination of aspirin plus ticagrelor.PMID:33926204 | DOI:10.1161/CIRCULATIONAHA.121.053782 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Gabriela Trifan Philip B Gorelick Fernando D Testai Source Type: research

The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Conclusions: Together, these findings suggest that the UPR exerts a protective effect in the setting of PLN R14del cardiomyopathy and that modulation of the UPR might be exploited therapeutically.PMID:33928785 | DOI:10.1161/CIRCULATIONAHA.120.049844 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Dries A M Feyen Isaac Perea-Gil Renee G C Maas Magdalena Harakalova Alexandra A Gavidia Jennifer Arthur Ataam Ting-Hsuan Wu Aryan Vink Jiayi Pei Nirmal Vadgama Albert J Suurmeijer Wouter P Te Rijdt Michelle Vu Prashila L Amatya Maricela Prado Yuan Zhang L Source Type: research

Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 - 2016
Conclusions: US adult cardiovascular spending increased by>$100 billion from 1996 to 2016. Policies tailored to control service price and intensity and preferentially reimburse higher quality care could help counteract future spending increases due to population aging and growth.PMID:33926203 | DOI:10.1161/CIRCULATIONAHA.120.053216 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Maxwell Birger Alexander S Kaldjian Gregory A Roth Andrew E Moran Joseph L Dieleman Brandon K Bellows Source Type: research

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Conclusions: DAPT decreases the risk of recurrent stroke and composite events compared with monotherapy. DAPT increases the risk of major hemorrhage, except if the treatment is limited to 30 days and does not include the combination of aspirin plus ticagrelor.PMID:33926204 | DOI:10.1161/CIRCULATIONAHA.121.053782 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Gabriela Trifan Philip B Gorelick Fernando D Testai Source Type: research

The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Conclusions: Together, these findings suggest that the UPR exerts a protective effect in the setting of PLN R14del cardiomyopathy and that modulation of the UPR might be exploited therapeutically.PMID:33928785 | DOI:10.1161/CIRCULATIONAHA.120.049844 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Dries A M Feyen Isaac Perea-Gil Renee G C Maas Magdalena Harakalova Alexandra A Gavidia Jennifer Arthur Ataam Ting-Hsuan Wu Aryan Vink Jiayi Pei Nirmal Vadgama Albert J Suurmeijer Wouter P Te Rijdt Michelle Vu Prashila L Amatya Maricela Prado Yuan Zhang L Source Type: research

Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 - 2016
Conclusions: US adult cardiovascular spending increased by>$100 billion from 1996 to 2016. Policies tailored to control service price and intensity and preferentially reimburse higher quality care could help counteract future spending increases due to population aging and growth.PMID:33926203 | DOI:10.1161/CIRCULATIONAHA.120.053216 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Maxwell Birger Alexander S Kaldjian Gregory A Roth Andrew E Moran Joseph L Dieleman Brandon K Bellows Source Type: research

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Conclusions: DAPT decreases the risk of recurrent stroke and composite events compared with monotherapy. DAPT increases the risk of major hemorrhage, except if the treatment is limited to 30 days and does not include the combination of aspirin plus ticagrelor.PMID:33926204 | DOI:10.1161/CIRCULATIONAHA.121.053782 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Gabriela Trifan Philip B Gorelick Fernando D Testai Source Type: research

The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Conclusions: Together, these findings suggest that the UPR exerts a protective effect in the setting of PLN R14del cardiomyopathy and that modulation of the UPR might be exploited therapeutically.PMID:33928785 | DOI:10.1161/CIRCULATIONAHA.120.049844 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Dries A M Feyen Isaac Perea-Gil Renee G C Maas Magdalena Harakalova Alexandra A Gavidia Jennifer Arthur Ataam Ting-Hsuan Wu Aryan Vink Jiayi Pei Nirmal Vadgama Albert J Suurmeijer Wouter P Te Rijdt Michelle Vu Prashila L Amatya Maricela Prado Yuan Zhang L Source Type: research

Spending on Cardiovascular Disease and Cardiovascular Risk Factors in the United States: 1996 - 2016
Conclusions: US adult cardiovascular spending increased by>$100 billion from 1996 to 2016. Policies tailored to control service price and intensity and preferentially reimburse higher quality care could help counteract future spending increases due to population aging and growth.PMID:33926203 | DOI:10.1161/CIRCULATIONAHA.120.053216 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Maxwell Birger Alexander S Kaldjian Gregory A Roth Andrew E Moran Joseph L Dieleman Brandon K Bellows Source Type: research

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Conclusions: DAPT decreases the risk of recurrent stroke and composite events compared with monotherapy. DAPT increases the risk of major hemorrhage, except if the treatment is limited to 30 days and does not include the combination of aspirin plus ticagrelor.PMID:33926204 | DOI:10.1161/CIRCULATIONAHA.121.053782 (Source: Circulation)
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Gabriela Trifan Philip B Gorelick Fernando D Testai Source Type: research

Variant Intronic Enhancer Controls < em > SCN10A-Short < /em > Expression and Heart Conduction
Conclusions: Genetic variants in and around SCN10A modulate enhancer function and expression of a cardiac-specific SCN10A-short transcript. We propose that non-coding genetic variation modulates transcriptional regulation of a functional C-terminal portion of NaV1.8 in cardiomyocytes that impacts on NaV1.5 function, cardiac conduction velocities and arrhythmia susceptibility.PMID:33910361 | DOI:10.1161/CIRCULATIONAHA.121.054083 (Source: Circulation)
Source: Circulation - April 29, 2021 Category: Cardiology Authors: Joyce C K Man Fernanda M Bosada Koen T Scholman Joost A Offerhaus Roddy Walsh Karel van Duijvenboden Vincent W W van Eif Connie R Bezzina Arie O Verkerk Bastiaan J Boukens Phil Barnett Vincent M Christoffels Source Type: research

< em > In Vivo < /em > Function of Flow-Responsive < em > Cis < /em > -DNA Elements of the Endothelial Nitric Oxide Synthase Gene: A Role for Chromatin-Based Mechanisms
Conclusions: We report, for the first time, that the SSRE and KLF elements are critical flow sensors necessary for a transcriptionally permissive, hypomethylated eNOS promoter in ECs under chronic SS in vivo. Moreover, eNOS expression is regulated by flow-dependent epigenetic mechanisms, which offers novel mechanistic insight on eNOS gene regulation in atherogenesis.PMID:33910388 | DOI:10.1161/CIRCULATIONAHA.120.051078 (Source: Circulation)
Source: Circulation - April 29, 2021 Category: Cardiology Authors: Kyung Ha Ku Michelle K Dubinsky Aravin N Sukumar Noeline Subramaniam Manon Y M Feasson Ranju Nair Eileen Tran Brent M Steer Britta J Knight Philip A Marsden Source Type: research

Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial
Conclusions: Neither denosumab nor alendronic acid affected progression of aortic valve calcification in patients with calcific aortic stenosis. Alternative pathways and mechanisms need to be explored to identify disease-modifying therapies for the growing population of patients with this potentially fatal condition. Clinical Trial Registration: https://www.clinicaltrials.gov Unique Identifier: NCT02132026.PMID:33913339 | DOI:10.1161/CIRCULATIONAHA.121.053708 (Source: Circulation)
Source: Circulation - April 29, 2021 Category: Cardiology Authors: Tania A Pawade Mhairi K Doris Rong Bing Audrey C White Laura Forsyth Emily Evans Catriona Graham Michelle C Williams Edwin J R van Beek Alison Fletcher Philip D Adamson Jack P M Andrews Timothy R G Cartlidge William S A Jenkins Maaz Syed Takeshi Fujisawa Source Type: research