Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in Humans

Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in Humans Fernanda Serpeloni1,2, Karl M. Radtke1,3, Tobias Hecker4, Johanna Sill1, Vanja Vukojevic5, Simone G. de Assis2, Maggie Schauer1, Thomas Elbert1 and Daniel Nätt6* 1Clinical Psychology and Neuropsychology, Department of Psychology, University of Konstanz, Konstanz, Germany 2Department of Studies in Violence and Health Jorge Careli, National School of Public Health of Rio de Janeiro – National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil 3Evolutionary Biology and Zoology, Department of Biology, University of Konstanz, Konstanz, Germany 4Clinical Psychology and Psychotherapy, Department of Psychology, Bielefeld University, Bielefeld, Germany 5Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland 6Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden Stress during pregnancy widely associates with epigenetic changes and psychiatric problems during childhood. Animal studies, however, show that under specific postnatal conditions prenatal stress may have other, less detrimental consequences for the offspring. Here, we studied mental health and epigenome-wide DNA methylation in saliva following intimate partner violence (IPV) duri...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Publication date: Available online 31 May 2020Source: Journal of Psychiatric ResearchAuthor(s): Makoto Kamiya, Helene D. Sabia, Julie Marella, Maurizio Fava, Charles B. Nemeroff, Hideo Umeuchi, Michihiko Iijima, Shigeyuki Chaki, Izumi Nishino
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Efforts to decompose heterogeneity in autism spectrum disorder (ASD) by identifying more homogeneous subgroups within ASD have a long history. Categorical diagnoses of ASD in previous editions of the DSM-III and DSM-IV, such as pervasive developmental disorders and Asperger ’s disorder, were among the earliest attempts to capture behavioral heterogeneity in ASD. However, these efforts to demonstrate quantifiable differences between the categorical groups were not particularly successful, which led to the shift to a single diagnosis of ASD in the DSM-5.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Early Career Investigator Commentary Source Type: research
to: “Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study on Depression and Anxiety,” by Lamers et al. (Biol Psychiatry 2019; 85:829–837); https://doi.org/10.1016/j.biopsych.2018.12.020.
Source: Biological Psychiatry - Category: Psychiatry Tags: Erratum Source Type: research
The advent and application of high-throughput sequencing is revolutionizing our understanding of the molecular neurobiology of diverse psychiatric disorders. Whole-genome sequencing, which targets the coding regions of the genome, and whole-exome sequencing are being applied to study multiple psychiatric disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, schizophrenia, and Tourette ’s disorder, among others [(1–3); https://schema.broadinstitute.org]. These studies have demonstrated a role for ultrarare, deleterious, frequently de novo variation in each disorder, and h...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Tourette syndrome (TS), also known as Tourette ’s disorder, is a neurodevelopmental disorder with onset in early childhood characterized by multiple motor tics and at least one vocal tic that have been present for longer than 1 year. TS is a model neuropsychiatric disorder, in that the vast majority of affected individuals, whether ascertained in clinical or community settings, experience at least one co-occurring psychiatric disorder, such as attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and/or mood, anxiety, and specific learning disorders (1).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Low levels of vitamin D are prevalent among patients with schizophrenia and have been linked to the risk and outcome of the disorder. Vitamin D has a regulatory effect on the inflammatory system, which is dysfunctional in schizophrenia. We investigated the association between serum vitamin D levels, inflammatory status, and severity of schizophrenia symptoms. A total of 39 clozapine-treated schizophrenia patients were recruited to the study. Blood samples for biochemical analysis were collected from all participants. Serum levels of vitamin D and cytokines (IL-4, IL-6, IL-10, and TNF-α) were analyzed and the associat...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
This study, based on the ‘Servizi Territoriali Associati per la Ricerca’ (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia. Despite all this effectiveness, it has side effects that can be serious and bothersome. Sialorrhea is the most common adverse drug reaction that occurs during clozapine treatment. It is usually persistent, may impair the patient’s quality of life and reduce treatment compliance. However, there is limited evidence to guide possible treatment strategies for sialorrhea. N-Acetylcysteine (NAC) is a powerful antioxidant. It acts directly as a scavenger of free radicals, in particular oxygen radicals. The antiox...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Case Report Source Type: research
In this position statement, developed by The International College of Obsessive-Compulsive Spectrum Disorders, a group of international experts responds to recent developments in the evidence-based management of obsessive-compulsive disorder (OCD). The article presents those selected therapeutic advances judged to be of utmost relevance to the treatment of OCD, based on new and emerging evidence from clinical and translational science. Areas covered include refinement in the methods of clinical assessment, the importance of early intervention based on new staging models and the need to provide sustained well-being involvin...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Review Articles Source Type: research
A high n-3, low n-6 fatty acid diet improved mood stability and reduced pain and irritability in patients with bipolar disorder.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
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