APOBEC3C is a novel target for the immune treatment of lower-grade gliomas
CONCLUSIONS: A3C is an immune-related prognostic biomarker in LGGs. Developing drugs to block A3C could enhance the efficiency of immunotherapy and improve disease survival.Abbreviation: A3C: Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) type 3C; LGGs: lower-grade gliomas; CGGA: Chinese Glioma Genome Atlas; WGCNA: Weighted gene co-expression network analysis; scRNA: Single-cell RNA; HGG: higher-grade glioma; OS: overall survival; TME: tumor microenvironment; KM: Kaplan-Meier; PFI: progression-free interval; IDH: isocitrate dehydrogenase; ROC: receiver operating characteristic; GS: gene significance; MM: module membership; TIMER: Tumor IMmune Estimation Resource; GSVA: gene set variation analysis; ssGSEA: single-sample gene-set enrichment analysis; PCA: principal component analysis; AUC: area under ROC curve; HAVCR2: hepatitis A virus cellular receptor 2; PDCD1: programmed cell death 1; PDCD1LG2: PDCD1 ligand 2; PTPRC: protein tyrosine phosphatase receptor type C; ACC: Adrenocortical carcinoma; BLCA: Bladder Urothelial Carcinoma;BRCA: Breast invasive carcinoma; CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOLCholangiocarcinoma; COADColon adenocarcinoma; DLBC: Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; HNSC: Head and Neck squamous cell carcinoma; KICH: Kidney Chromophobe; KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LAML: Acute...
Source: Neurological Research - Category: Neurology Authors: Shufa Zhao Yuntao Li Jie Xu Liang Shen Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Adenocarcinoma | Adrenocortical Carcinoma | Asbestosis | Bladder Cancer | Brain | Brain Cancers | Brain Tumor | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer of the Uterus | Carcinoma | Carcinosarcoma | Cervical Cancer | Chemotherapy | China Health | Clear Cell Carcinoma | Colorectal Cancer | Endometrial Cancer | Esophagus Cancer | Eye Cancers | Gastric (Stomach) Cancer | Genetics | Germ Cell Tumors | Glioma | Head and Neck Cancer | Hepatitis | Hepatitis A | Hepatocellular Carcinoma | HNSCC | Immunotherapy | Leukemia | Liver | Liver Cancer | Lymphoma | Melanoma | Mesothelioma | Molecular Biology | Neurology | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Paraganglioma | Pheochromocytoma | Sarcomas | Serous Carcinoma | Skin | Skin Cancer | Squamous Cell Carcinoma | Study | Thyroid | Thyroid Cancer | Urology & Nephrology | Uveal Melanoma