New TREMFYA ® (guselkumab) Post-Hoc Analysis Reveals Active Psoriatic Arthritis Patients With Early Efficacy Had Meaningful Long-Term Improvement in Health-Related Quality of Life

SPRING HOUSE, PENNSYLVANIA, November 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced a new post-hoc analysis of the Phase 3 DISCOVER-2 study that show early (week 8) clinical improvementsa of most measures (joint and skin disease, enthesitis and dactylitis) in adult patients with active psoriatic arthritis (PsA) treated with TREMFYA® (guselkumab) were associated with meaningful improvements in health-related quality of life (HRQoL) (measured by EQ-5D)b from year one (week 52) through year two (week 100).1 TREMFYA is the first fully human selective interleukin (IL)-23 inhibitor therapy approved in the U.S. for adults with active PsA and adults with moderate to severe plaque psoriasis (PsO).2People with active PsA can experience both physical and mental health challenges that can interfere with their daily lives and impact their work and relationships. Additionally, some patients experience fatigue – a burdensome symptom that often can be underestimated and underreported.3In a separate post-hoc analysis of DISCOVER-2, clinically meaningful improvements in fatigue (measured by Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F])c observed at one year in TREMFYA-treated patients were enhanced through two years, resulting in greater proportions of patients achieving normative FACIT-F levels.4“Patients with active psoriatic arthritis may struggle with engaging in everyday tasks as a result of health-related quality of l...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Latest News Source Type: news