IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
Am J Physiol Cell Physiol. 2024 Mar 4. doi: 10.1152/ajpcell.00654.2023. Online ahead of print.ABSTRACTSkeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome these limitations. We monitored the differentiation process starting from primary human CD56-positive myoblasts in...
Source: Am J Physiol Cell Ph... - May 1, 2024 Category: Cytology Authors: Simon I Dreher Paul Grubba Christine von Toerne Alessia Moruzzi Jennifer Maurer Thomas Goj Andreas L Birkenfeld Andreas Peter Peter Loskill Stefanie M Hauck Cora Weigert Source Type: research
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway
This study establishes the crucial role of CD200R in HG-induced oxidative stress and identifies potential therapeutic avenues for the treatment of DR.PMID:38692160 | DOI:10.1016/j.tice.2024.102381 (Source: Tissue and Cell)
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Yaguang Hu Ting Wei Shan Gao Ning Gao Li Chen Qiaochu Cheng Source Type: research
The relation between autophagy modulation by intermittent fasting and aquaporin 2 expression in experimentally induced diabetic nephropathy in albino rat
This study aimed to describe the relation between autophagy modulation via intermittent fasting (IF) and renal AQP2 expression and polyuria in case of DN. We divided the rats into control, DN and IF groups. After 2 and 4 weeks of diabetes induction, blood glucose (BG), serum creatinine (Scr), urine volume, and 24 hours urine protein (UP) were examined. Diabetic nephropathy histopathological index (DNHI) was calculated to evaluate histopathological changes. Immunohistochemistry and real-time PCR were performed to measure the levels of AQP2 and the autophagy marker; LC3 in kidney tissue. DNHI was correlated to the PCR and im...
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Nora Hisham Hassan Dalia Saleh Salwa M Abo El-Khair Shaima M Almasry Amira Ibrahim Source Type: research
IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
Am J Physiol Cell Physiol. 2024 Mar 4. doi: 10.1152/ajpcell.00654.2023. Online ahead of print.ABSTRACTSkeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome these limitations. We monitored the differentiation process starting from primary human CD56-positive myoblasts in...
Source: American Journal of Physiology. Cell Physiology - May 1, 2024 Category: Cytology Authors: Simon I Dreher Paul Grubba Christine von Toerne Alessia Moruzzi Jennifer Maurer Thomas Goj Andreas L Birkenfeld Andreas Peter Peter Loskill Stefanie M Hauck Cora Weigert Source Type: research
Evidence-based screening, clinical care and health education recommendations for Alaska Native peoples with prediabetes living in southcentral Alaska: findings from the Alaska EARTH follow-up study
This study investigated how much of the recent increase in pre-DM identified among Alaska Native (AN) peoples living in urban southcentral Alaska may be due to changes in diagnostic methods. We used clinical and demographic data collected at baseline between 2004 and 2006 and at follow-up collected between 2015 and 2017 from the urban southcentral Alaska Education and Research Towards Health (EARTH) cohort. We used descriptive statistics and logistic regression to explore differences in demographic and clinical variables among the identified pre-DM groups. Of 388 participants in the follow-up study, 243 had A1c levels indi...
Source: International Journal of Circumpolar Health - May 1, 2024 Category: International Medicine & Public Health Authors: Kathryn R Koller Sarah H Nash Julie A Beans Gretchen M Day Vanessa Y Hiratsuka Ai-Ling Lin Meera Narayanan Christi A Patten Sherry A Hammock Barbara V Howard Jason G Umans Source Type: research
Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis
Am J Physiol Endocrinol Metab. 2024 May 1. doi: 10.1152/ajpendo.00069.2024. Online ahead of print.ABSTRACTPancreatic endocrine cells employ a sophisticated system of paracrine and autocrine signals to synchronize their activities, including glutamate which controls hormone release and β-cell viability by acting on glutamate receptors expressed by endocrine cells. We here investigate whether alteration of the Excitatory Amino Acid Transporter 2 (EAAT2), the major glutamate clearance system in the islet, may occur in type 2 diabetes mellitus (T2DM) and contribute to β-cell dysfunction. Increased EAAT2 intracellular localiz...
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Alessandra Galli Stefania Moretti Nevia Dule Eliana Sara Di Cairano Michela Castagna Paola Marciani Cristina Battaglia Federico Bertuzzi Ida Pastore Paolo Fiorina Stefano La Rosa Alberto Davalli Franco Folli Carla Perego Source Type: research
Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
Genetic and Lifestyle Risk Factors of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Relationship with Premature Coronary Artery Disease: A Study on the Pars Cohort
CONCLUSION: Our study found that consuming opium decreases the likelihood of MAFLD in CAD patients, since these patients have decreased appetite and lower body mass index (BMI). On the other hand, female gender, having diabetes, high waist circumference, high triglyceride levels, and high ALT levels increase the probability of MAFLD in CAD patients.PMID:38690791 | DOI:10.34172/aim.2024.36 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Amir Anushiravani Maryam Rayatpisheh Amir Kasaeian Iman Menbari Oskouie Source Type: research
Widespread Adoption of Microincision Vitrectomy Surgery Improves Visual Outcomes in Endogenous Endophthalmitis with Poor Initial Vision: A 21-Year Experience in Taiwan
CONCLUSION: In endogenous endophthalmitis patients presenting with poor initial visual acuity, vitrectomy was a better visual prognostic factor. MIVS has allowed more patients to undergo vitrectomy and improved visual outcomes.PMID:38691837 | DOI:10.1080/09273948.2024.2338272 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 1, 2024 Category: Allergy & Immunology Authors: Shih-Chou Chen Tsung-Tien Wu Chun-Hao Yin Jin-Shuen Chen Yao-Shen Chen Source Type: research
Causal Association Between Diabetes, Body Mass Index and Lichen Sclerosus: A Bidirectional Two-Sample Mendelian Randomization Analysis
CONCLUSION: This MR analysis demonstrated no significant causal relationship between DM and BMI with LS in both directions, which contradicts previous observational studies reporting a positive association. Potential confounding factors may contribute to previously observed associations, and further research is necessary.PMID:38689755 | PMC:PMC11060172 | DOI:10.2147/CCID.S450399 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Lin Liu Qiuli Zhang Jianmin Chang Kun Yang Source Type: research
Update on the development of TGR5 agonists for human diseases
Eur J Med Chem. 2024 Apr 28;271:116462. doi: 10.1016/j.ejmech.2024.116462. Online ahead of print.ABSTRACTThe G protein-coupled bile acid receptor 1 (GPBAR1) or TGR5 is widely distributed across organs, including the small intestine, stomach, liver, spleen, and gallbladder. Many studies have established strong correlations between TGR5 and glucose homeostasis, energy metabolism, immune-inflammatory responses, and gastrointestinal functions. These results indicate that TGR5 has a significant impact on the progression of tumor development and metabolic disorders such as diabetes mellitus and obesity. Targeting TGR5 represents...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Wangrui Jin Mingyue Zheng Yihua Chen Hai Xiong Source Type: research
< em > Klebsiella pneumoniae < /em > infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
CONCLUSION: KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.PMID:38689752 | PMC:PMC11056902 | DOI:10.4254/wjh.v16.i4.612 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Long Guo Peng Peng Wei-Ting Peng Jie Zhao Qi-Quan Wan Source Type: research
Characteristics of Human Leukocyte Antigen Class II Genes in Japanese Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J027. Online ahead of print.NO ABSTRACTPMID:38692862 | DOI:10.1620/tjem.2024.J027 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Risa Kajita Haruna Takahashi Satoshi Yoshino Shunichi Matsumoto Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Eijiro Yamada Source Type: research
Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: J Rheumatol)
Source: J Rheumatol - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
