Predictive factors of post-HoLEP incontinence: differences between stress and urgency urinary incontinence
ConclusionIn the first month post-HoLEP, age is a predictive factor of urgency UI and stress UI. In addition, prostatic volume and the presence of an indwelling urinary catheter are predictive factors of stress UI. (Source: World Journal of Urology)
Source: World Journal of Urology - May 2, 2024 Category: Urology & Nephrology Source Type: research
Deciphering mortality risk of diabetes medications in heart failure patients with diabetes mellitus under triple guideline-directed medical therapy
Scientific evidence regarding the impact of different combinations of diabetes medications in heart failure patients with diabetes mellitus (HFwDM) remains limited. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 2, 2024 Category: Cardiology Authors: İnci Tuğçe Çöllüoğlu, Ahmet Çelik, Naim Ata, Dilek Ural, Anıl Şahin, Mustafa Mahir Ulgu, Emine Arzu Kanık, Şuayip Birinci, Mehmet Birhan Yılmaz Source Type: research
Complement regulation in the eye: implications for age-related macular degeneration
Careful regulation of the complement system is critical for enabling complement proteins to titrate immune defense while also preventing collateral tissue damage from poorly controlled inflammation. In the eye, this balance between complement activity and inhibition is crucial, as a low level of basal complement activity is necessary to support ocular immune privilege, a prerequisite for maintaining vision. Dysregulated complement activation contributes to parainflammation, a low level of inflammation triggered by cellular damage that functions to reestablish homeostasis, or outright inflammation that disrupts the visual a...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Georgia A. Wilke, Rajendra S. Apte Source Type: research
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
Dr. Bernal
Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout?
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are known to decrease serum urate levels and the risk of incident gout. However, their role in secondary prevention of gout flares is unknown.
Study design: Propensity score–matched, new-user cohort study
Setting: British Columbia, Canada
Synopsis: Using a group of population-based, linked, administrative databases, the population of British Columbia was studied. 15,067 patients with gout and type 2 diabetes had f...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Autoimmune Diseases In the Literature Pharmacology Rheumatology Source Type: research
Semaglutide in Patients with HFpEF and Obesity
This study enrolled adult patients with obesity (BMI ≥30 kg/m2), HFpEF (left ventricular ejection fraction ≥45%; and New York Heart Association functional class II, III, or IV), a Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) of less than 90 points, a six-minute walk distance of at least 100 m; and clinical or laboratory evidence of volume-overloaded HF. About 500 participants, median age of 69, were randomized to receive semaglutide 2.4 mg subcutaneously weekly, versus placebo for 52 weeks. In patients randomized to receive semaglutide, there was an improvement in self-reported HF symptoms...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Cardiology In the Literature Pharmacology Source Type: research
Effect of Maternal Pre-Pregnancy Body Mass Index on Longitudinal Fetal Growth and Mediating Role of Maternal Fasting Plasma Glucose: A Retrospective Cohort Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 1, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Hypoxia-inducible factor-1 α in myocardial infarction
World J Cardiol. 2024 Apr 26;16(4):181-185. doi: 10.4330/wjc.v16.i4.181.ABSTRACTHypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism. Furthe...
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Ivana Škrlec Sergey N Kolomeichuk Source Type: research
Event-Related Potential Changes Following 12-week Yoga Practice in T2DM Patients: A Randomized Controlled Trial
Conclusion. The 12-week yoga practice improved cognitive performance by enhancing the processes of conflict monitoring and response inhibition. Further, improved cognitive performance postintervention was facilitated by improved glycemic control.PMID:38689456 | DOI:10.1177/15500594241249511 (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 1, 2024 Category: Neuroscience Authors: Amit Kanthi Singh Deepeshwar Kaligal Chidananda Mahadevappa Vidyashree Dwivedi Krishna Source Type: research
IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
Am J Physiol Cell Physiol. 2024 Mar 4. doi: 10.1152/ajpcell.00654.2023. Online ahead of print.ABSTRACTSkeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome these limitations. We monitored the differentiation process starting from primary human CD56-positive myoblasts in...
Source: Am J Physiol Cell Ph... - May 1, 2024 Category: Cytology Authors: Simon I Dreher Paul Grubba Christine von Toerne Alessia Moruzzi Jennifer Maurer Thomas Goj Andreas L Birkenfeld Andreas Peter Peter Loskill Stefanie M Hauck Cora Weigert Source Type: research
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway
This study establishes the crucial role of CD200R in HG-induced oxidative stress and identifies potential therapeutic avenues for the treatment of DR.PMID:38692160 | DOI:10.1016/j.tice.2024.102381 (Source: Tissue and Cell)
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Yaguang Hu Ting Wei Shan Gao Ning Gao Li Chen Qiaochu Cheng Source Type: research
The relation between autophagy modulation by intermittent fasting and aquaporin 2 expression in experimentally induced diabetic nephropathy in albino rat
This study aimed to describe the relation between autophagy modulation via intermittent fasting (IF) and renal AQP2 expression and polyuria in case of DN. We divided the rats into control, DN and IF groups. After 2 and 4 weeks of diabetes induction, blood glucose (BG), serum creatinine (Scr), urine volume, and 24 hours urine protein (UP) were examined. Diabetic nephropathy histopathological index (DNHI) was calculated to evaluate histopathological changes. Immunohistochemistry and real-time PCR were performed to measure the levels of AQP2 and the autophagy marker; LC3 in kidney tissue. DNHI was correlated to the PCR and im...
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Nora Hisham Hassan Dalia Saleh Salwa M Abo El-Khair Shaima M Almasry Amira Ibrahim Source Type: research
IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
Am J Physiol Cell Physiol. 2024 Mar 4. doi: 10.1152/ajpcell.00654.2023. Online ahead of print.ABSTRACTSkeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome these limitations. We monitored the differentiation process starting from primary human CD56-positive myoblasts in...
Source: American Journal of Physiology. Cell Physiology - May 1, 2024 Category: Cytology Authors: Simon I Dreher Paul Grubba Christine von Toerne Alessia Moruzzi Jennifer Maurer Thomas Goj Andreas L Birkenfeld Andreas Peter Peter Loskill Stefanie M Hauck Cora Weigert Source Type: research
Evidence-based screening, clinical care and health education recommendations for Alaska Native peoples with prediabetes living in southcentral Alaska: findings from the Alaska EARTH follow-up study
This study investigated how much of the recent increase in pre-DM identified among Alaska Native (AN) peoples living in urban southcentral Alaska may be due to changes in diagnostic methods. We used clinical and demographic data collected at baseline between 2004 and 2006 and at follow-up collected between 2015 and 2017 from the urban southcentral Alaska Education and Research Towards Health (EARTH) cohort. We used descriptive statistics and logistic regression to explore differences in demographic and clinical variables among the identified pre-DM groups. Of 388 participants in the follow-up study, 243 had A1c levels indi...
Source: International Journal of Circumpolar Health - May 1, 2024 Category: International Medicine & Public Health Authors: Kathryn R Koller Sarah H Nash Julie A Beans Gretchen M Day Vanessa Y Hiratsuka Ai-Ling Lin Meera Narayanan Christi A Patten Sherry A Hammock Barbara V Howard Jason G Umans Source Type: research
Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis
Am J Physiol Endocrinol Metab. 2024 May 1. doi: 10.1152/ajpendo.00069.2024. Online ahead of print.ABSTRACTPancreatic endocrine cells employ a sophisticated system of paracrine and autocrine signals to synchronize their activities, including glutamate which controls hormone release and β-cell viability by acting on glutamate receptors expressed by endocrine cells. We here investigate whether alteration of the Excitatory Amino Acid Transporter 2 (EAAT2), the major glutamate clearance system in the islet, may occur in type 2 diabetes mellitus (T2DM) and contribute to β-cell dysfunction. Increased EAAT2 intracellular localiz...
Source: American Journal of Physiology. Endocrinology and Metabolism - May 1, 2024 Category: Physiology Authors: Alessandra Galli Stefania Moretti Nevia Dule Eliana Sara Di Cairano Michela Castagna Paola Marciani Cristina Battaglia Federico Bertuzzi Ida Pastore Paolo Fiorina Stefano La Rosa Alberto Davalli Franco Folli Carla Perego Source Type: research
Circulating interleukin 17A and other inflammatory proteins may predict cardiovascular disease in early rheumatoid arthritis
CONCLUSION: Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Furthermore, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.PMID:38692670 | DOI:10.3899/jrheum.2023-1078 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 1, 2024 Category: Rheumatology Authors: Emil Rydell Lennart T H Jacobsson Carl Turesson Source Type: research
