ASAS Health Index: The "All in One" for Spondyloarthritis Evaluation?
ASAS Health Index: The "All in One" for Spondyloarthritis Evaluation? J Rheumatol. 2020 Oct 01;47(10):1457-1460 Authors: Kiltz U, Wendling D, Braun J PMID: 33004479 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Storm Beneath the Storm: MAS-HLH in Inflammatory Myopathies.
Authors: Schulert GS PMID: 33004480 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Iliopsoas Muscle Involvement due to Granulomatosis with Polyangiitis.
Authors: Taniguchi Y, Nishikawa H PMID: 33004481 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Correction.
Authors: PMID: 33004482 [PubMed] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Correction.
Authors: PMID: 33004483 [PubMed] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Clinical phenotyping of primary Sj ögren's patients using salivary gland ultrasonography - data from the RESULT cohort.
CONCLUSION: SGUS positive patients show a distinct clinical phenotype compared with SGUS negative patients in all aspects of the disease: clinical, functional, serological and PROMs. SGUS could be a helpful tool in selecting patients for clinical trials and estimating treatment need. PMID: 33004530 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Time-trends in Opioid Use Disorder Hospitalizations in Gout, Rheumatoid arthritis, Fibromyalgia, Osteoarthritis, and Low Back Pain.
CONCLUSION: OUD-hospitalizations increased in all 5 musculoskeletal diseases studied, but the rate of increase differed. Awareness of these OUD-hospitalization trends in 5 musculoskeletal diseases among providers, policy-makers and patients is important. Development and implementation of interventions, policies and practices to potentially reduce OUD-associated impact in people with rheumatic diseases is needed. PMID: 33004531 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Impact of Multidomain Disease Presentations on Patients With Psoriatic Arthritis in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.
CONCLUSION: In this US real-world cohort, most patients had multidomain disease presentations, which was associated with worse disease activity, QOL, and work productivity measures. This study highlights the heterogeneity of PsA and the importance of assessing all PsA domains for optimizing disease management. PMID: 33004532 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Infertility Causes and Pregnancy Outcome in Patients With Familial Mediterranean Fever (FMF) and Controls.
CONCLUSION: Colchicine medication and controlled FMF disease do not adversely affect the reproductive system and pregnancy outcome. However, a lack of an appropriate colchicine treatment may cause infertility and poor pregnancy outcome. PMID: 33004533 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Tofacitinib Persistence in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study.
CONCLUSION: Further research is warranted to understand the reasons for discontinuation of tofacitinib despite its ease of administration and to understand the observed differences between switchers and new users. PMID: 33004534 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Variability in Urate-lowering Therapy Prescribing: A Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) Physician Survey.
Authors: Stamp LK, Taylor W, Gaffo A Abstract Gout is common in people with chronic kidney disease (CKD) and its treatment is frequently suboptimal in this special population due to concerns over adverse events and/or efficacy of medications. There is controversy about the use of urate-lowering therapy (ULT) in those with CKD and lack of agreement about the dosing of allopurinol, the recommended first-line ULT1,2. PMID: 33004535 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

STRATUS, a Phase II Study of Abituzumab in Patients with Systemic Sclerosis-associated Interstitial Lung Disease.
CONCLUSION: Further investigation of abituzumab for treatment of SSc-ILD is required. PMID: 33004536 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Effect of stem cell injections on osteoarthritis-related structural outcomes - a systematic review.
CONCLUSION: This systematic review of early phase clinical trials showed consistent evidence for a beneficial effect of intra-articular MSC injections on articular cartilage and subchondral bone. Due to the heterogeneity of MSCs, modest sample sizes, methodological limitations, and potential for publication bias, further work is needed before this therapy is recommended in the management of osteoarthritis. PMID: 33004537 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Urinary N-telopeptide as a Biomarker of Disease Activity in Patients with Chronic Nonbacterial Osteomyelitis Who Have Not Received Bisphosphonates.
Authors: Perkins A, Stevens A, Ferguson PM, Zhao Y Abstract Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory disease that causes bone destruction, soft tissue swelling, and bone pain1 Diagnosis and treatment are hindered by a lack of a reliable laboratory test to assess disease activity. Bone inflammation in CNO is associated with increased osteoclastic activity and bone resorption, causing focal accelerated breakdown of bone collagen. PMID: 33004538 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Long Term Follow-up and Optimization of Infliximab in Refractory Uveitis Due to Beh çet's Disease. National Study of 103 Caucasian Patients.
CONCLUSION: IFX seems to be effective and relatively safe in Caucasian patients with refractory BD uveitis. IFX optimization is effective, safe, and cost-effective. PMID: 33004539 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - October 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Evaluating quality of care for rheumatoid arthritis for the population of Alberta using system-level performance measures.
CONCLUSION: The existing Alberta health care system for RA is suboptimal, indicating barriers to accessing specialty care and treatment. The results inform quality improvement initiatives required within the province to meet national standards of care. PMID: 32934120 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Reliability and Change in Erosion Measurements by High-Resolution peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients.
CONCLUSION: This exercise confirmed good reliability of HR-pQCT erosion measurements and their ability to detect change over time. PMID: 32934121 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Serological Status Affects the Prognostic Role of Salivary Gland Histology in Primary Sj ögren Syndrome.
The Serological Status Affects the Prognostic Role of Salivary Gland Histology in Primary Sjögren Syndrome. J Rheumatol. 2020 Sep 15;: Authors: Carubbi F, Alunno A Abstract We read with interest the article by Sharma, et al that evaluated a cohort of patients with symptoms of mucosal dryness undergoing diagnostic workup for the suspicion of primary Sjögren syndrome (pSS)1 The assessment also included a minor salivary gland (MSG) biopsy and patients were classified as pSS if fulfilling the histological [focus score (FS) ≥ 1], serological (anti-Ro based on the American College of Rheumatolog...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

CanVasc consensus recommendations for the management of antineutrophil cytoplasm antibody-associated vasculitis: 2020 update.
CONCLUSION: The 2020 updated recommendations provide rheumatologists, nephrologists, and other specialists caring for patients with AAV in Canada with new management guidance, based on current evidence and consensus from Canadian experts. PMID: 32934123 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Biologic Switching among Non-Systemic Juvenile Idiopathic Arthritis Patients: A Cohort Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.
CONCLUSION: In a multicenter cohort of patients with JIA starting a biologic, one-quarter switched to a second biologic, and the time to switching decreased in recent years. Additional studies should evaluate the outcomes and optimal timing of switching and preferred sequence of biologic use. PMID: 32934124 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Covid-19 in Patients with Connective Tissue Disease-Related Interstitial Lung Disease.
Authors: Troung L, Pourzand L, Volkmann ER Abstract Infection with the coronavirus disease 2019 (Covid-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), manifests in a myriad of ways ranging from asymptomatic disease to pneumonia and acute respiratory distress syndrome. Advanced age and underlying cardiovascular/pulmonary conditions appear to increase the risk for Covid-19 complications [1,2]. PMID: 32934125 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Elevated Levels of G-CSF in Patients with Active Phase of Adult-onset Still's Disease.
Authors: Liu Y, Zhang S, Xia C, Chen J, Fan C Abstract OBJECTIVE: Neutrophilia is a hallmark of adult-onset Still's disease (AoSD). We aimed to investigate the levels of granulocyte colony-stimulating factor (G-CSF), an essential regulator of neutrophil production and function, in the pathogenesis of AoSD. METHODS: Sera were collected from 70 patients with AoSD and 20 healthy controls (HCs). The levels of G-CSF were determined by ELISA. Low-density granulocytes (LDGs) were quantified by flow cytometry. Correlations between G-CSF levels and disease activity, laboratory parameters, or LDGs levels in patients with...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Drs. Monsalve and Anaya reply.
Authors: Monsalve DM, Anaya JM Abstract We would like to thank Dr. Panchovska for her comments on our editorial1, which was motivated by the work of Sharma, et al 2, who reported patients with sicca (100%) and other symptoms such as arthralgia (82%) and constitutional symptoms (43%) among others, in whom the presence of anti-Ro/SSA antibodies allowed a diagnosis of Sjögren syndrome (SS) despite a negative minor salivary gland (MSG) biopsy [i.e., focus score (FS) = 0]. PMID: 32934127 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Drs. Rasmussen and Scofield reply.
Authors: Rasmussen A, Scofield RH Abstract The cardinal laboratory/pathological features of Sjögren syndrome (SS) are autoantibodies (anti-Ro/SSA and anti-La/SSB) and lymphocytic infiltrate of the salivary glands. The lymphocytic infiltrate is graded by the focus score (FS) 1, 2, which is the number of foci with ≥ 50 lymphocytes per 4 mm2 Much has been published about the clinical and laboratory differences found among Sjögren patients with and without autoantibodies, with the presence of anti-Ro generally associated with more severe disease2,3 However, comparatively few studies have been directed at s...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Prediction of work impact in axial spondylarthritis by the Work instability Scale, a prospective cohort study of 101 patients.
CONCLUSION: In patients with axSpA, a moderate/high AS-WIS score was predictive of AWO in this population with well-controlled axSpA. This short questionnaire can be helpful to screen for future difficulties at work. PMID: 32934129 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Attitudes and Behaviours of Patients with Rheumatic Diseases during the early stages of the COVID-19 Outbreak.
CONCLUSION: We identified three clusters with different healthcare beliefs and distinct sociodemographics. PMID: 32934130 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Whole-body MRI Quantification for Assessment of Bone Lesions in CNO Patients Treated with Pamidronate: A Prevalence, Reproducibility, and Responsiveness Study.
CONCLUSION: WB-MRI is a reliable tool for objective quantification and assessment of response to treatment of pediatric CNO bone lesions and could be used to monitor disease activity for clinical and research purposes. PMID: 32934131 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Intramuscular Pressure is Almost Three Times Higher in Fibromyalgia Patients: A Possible Mechanism for Understanding the Muscle Pain and Tenderness.
This study examines intramuscular pressure in the trapezius as an alternative mechanism for understanding FMS pain. METHODS: 108 patients who satisfied the ACR criteria for FMS and 30 patients who met the ACR criteria for another rheumatic disease comprised the study groups. Muscle pressure was measured in mmHg using a pressure gauge attached to a No. 22 needle inserted into the mid portion of the trapezius muscle. In addition, FMS patients and rheumatic disease controls had dolorimetry testing, digital palpation, and reported pain scores. RESULTS: Muscle pressure was substantially higher in patients with FMS with ...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Questions From Patients and Doctors on Negative Minor Salivary Gland Biopsy in Sj ögren Syndrome.
Questions From Patients and Doctors on Negative Minor Salivary Gland Biopsy in Sjögren Syndrome. J Rheumatol. 2020 Sep 15;: Authors: Panchovska M Abstract I read with interest the editorial in The Journal of Rheumatology entitled, "With Minor Salivary Gland Biopsy in Sjögren Syndrome, Is a Negative Result Possible?" by Drs. Monsalve and Anaya1 It is a comment on the article by Sharma, et al 2, arguing that in the case of a negative biopsy of minor salivary glands (MSG), the presence of positive anti-Ro autoantibodies is sufficient for the diagnosis of Sjögren syndrome (SS). ...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Salivary Gland Focus Score is Associated with Myocardial Fibrosis in Primary Sj ögren's Syndrome Assessed by a Cardiac Magnetic Resonance Approach.
CONCLUSION: Subclinical myocardial fibrosis, as detected by CMR, was frequent in patients with pSS without cardiac symptoms. Abnormal CMR findings were associated with salivary gland FS ≥3. PMID: 32934134 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Drs. Rasmussen and Scofield reply.
Authors: Rasmussen A, Scofield RH Abstract Cafaro and colleagues1 have studied focus score (FS)-negative (that is,
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

National Sj ӧgren's Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life.
CONCLUSION: Oral manifestations of SS, particularly mouth ulcers or sores, trouble speaking, and dysphagia, were strongly associated with worse quality of life. Further study and targeted treatment of these oral manifestations provides the opportunity to improve quality of life in patients with SS. PMID: 32934136 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Pegloticase in combination with methotrexate in patients with uncontrolled gout: A multicenter, open-label study (MIRROR).
Authors: Botson JK, Tesser JRP, Bennett R, Kenney HM, Peloso PM, Obermeyer K, LaMoreaux B, Weinblatt ME, Peterson J Abstract OBJECTIVE: To examine the efficacy and safety of pegloticase in combination with methotrexate in patients with uncontrolled gout in an exploratory, open-label clinical trial (NCT03635957) prior to a randomized, controlled trial. METHODS: A multicenter, open-label, efficacy and safety study of pegloticase with methotrexate cotreatment was conducted in patients with uncontrolled gout. Patients were administered oral methotrexate (15 mg/week) and folic acid (1 mg/day) 4 weeks prior to and th...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Association Between Glandular Infiltrate and Leukopenia in Sj ögren Syndrome (SS): Data From the Italian Research Group on SS (GRISS).
Association Between Glandular Infiltrate and Leukopenia in Sjögren Syndrome (SS): Data From the Italian Research Group on SS (GRISS). J Rheumatol. 2020 Sep 15;: Authors: Cafaro G, Gerli R, Bartoloni E Abstract We read with great interest the paper by Sharma, et al 1, who analyzed a cohort of patients with primary Sjögren syndrome (pSS), evaluating differences between a subgroup of subjects with positive minor salivary gland (MSG) biopsy compared to patients with a negative MSG biopsy. The authors found a higher prevalence of anti-La positivity and increased levels of IgG in the former group a...
Source: Journal of Rheumatology - September 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

IgA Vasculitis with Underlying Liver Cirrhosis: a French Nationwide Case Series of 20 Patients.
Authors: Elhani I, Pillebout E, Terrier B, Hankard A, Vrtovsnik F, Jourde-Chiche N, Greillier S, Groh M, Belfeki N, Bigot A, de Boysson H, Pageaux GP, Raffray L, Urbanski G, Ollivier I, Maillot F, Aouba A, Audemard-Verger A, French Vasculitis Study Group (FVSG) and the HSPrognosis group Abstract OBJECTIVE: IgA vasculitis (IgAV) and nephropathy (IgAN) share common immunological mechanisms. Liver cirrhosis is well-known to be associated with IgAN. Here, we aimed to describe the presentation and outcome of IgAV patients with underlying cirrhosis. METHODS: We conducted a French nationwide retrospective study of adu...
Source: Journal of Rheumatology - August 19, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The risk of cardiovascular events associated with disease-modifying antirheumatic drugs in rheumatoid arthritis.
CONCLUSION: Abatacept and TNFi were associated with decreased risk of CVD compared to csDMARDs. Minimizing glucocorticoid use and optimizing MTX dose may improve CV outcomes in patients with RA. PMID: 32801134 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - August 19, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Epidermal Neurite Density in Skin Biopsies from Patients with Juvenile Fibromyalgia.
Authors: Boneparth A, Chen S, Horton DB, Moorthy LN, Farquhar I, Downs HM, Lee H, Oaklander AL Abstract OBJECTIVE: Fibromyalgia is defined by idiopathic, chronic, widespread musculoskeletal pain. In adults with fibromyalgia, meta-analysis of lower-leg skin biopsy demonstrated 45% pooled prevalence of abnormally low epidermal neurite density (END). END
Source: Journal of Rheumatology - August 19, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Febuxostat use and risks of CVD events, death from cardiac-cause and all-cause mortality: metaanalysis of randomized controlled trials.
CONCLUSION: Febuxostat use is not associated with increased risks of all-cause mortality, death from CVD or CVD events. Accordingly, it is a safe drug for the treatment of gout. Systematic review registration: PROSPERO CRD42019131872. PMID: 32801136 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - August 19, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The USSe (UltraSound Score for Erosions) in the evaluation of bone erosions in RA compared to the SHSe (Van der Heijde-modified Sharp score for erosions).
Authors: Grosse J, Allado E, Albuisson É, Pierreisnard A, Couderc M, Chary-Valckenaere I, Loeuille D Abstract OBJECTIVE: To evaluate the relationship between the UltraSound Score for Erosions (USSe) and the Van der Heijde-modified Sharp score for erosions (SHSe). METHODS: 108 rheumatoid arthritis (RA) patients were included. On radiography: SHSe was evaluated by two or three blinded readers (in case of discordance). On ultrasonography: erosions were scored on six bilateral joints (MCP2,3,5; MTP2,3,5) with a four-point scale to calculate the USSe. RESULTS: The Pearson's correlation was good (r=0.68, p
Source: Journal of Rheumatology - August 19, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Walk at least 10 minutes a day for adults with knee OA: Recommendation for minimal activity during the COVID-19 pandemic.
Authors: Jakiela JT, Waugh EJ, White DK Abstract The emergence of Coronavirus Disease 2019 (COVID-19) has resulted in unprecedented changes in how the world socially interacts. Limits on contact with others, whether by social distancing or shelter-at-home recommendations, have negatively impacted physical activity (PA), which is especially true for adults over the age of 60 who are at high risk of serious illness from COVID-19. PMID: 32801138 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - August 19, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The pattern of musculoskeletal complaints in patients with suspected psoriatic arthritis and their correlation with physical examination and ultrasound.
CONCLUSION: The results of this study suggest that the intensity, rather than the type, duration or distribution of musculoskeletal symptoms is associated with PsA among patients with psoriasis. PMID: 32414953 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 18, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Are OMERACT knee osteoarthritis ultrasound scores associated with pain severity, other symptoms, radiographic and MRI findings?
CONCLUSION: OMERACT ultrasound scores revealed significant associations with pain severity, KLG and MOAKS. PMID: 32414954 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 18, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Hearing Loss in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-Analysis.
CONCLUSION: Patients with AS have higher odds of having HL over patients without AS. This population also presents with significantly impaired hearing thresholds across all conventional and extended pure tone frequencies. This may manifest as slight to moderate hearing loss. Results of this systematic review might justify increased attention audiologic manifestations of patients with AS. PMID: 32414955 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 18, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Infections are associated with increased risk of giant cell arteritis - a population-based case-control study from Southern Sweden.
CONCLUSION: Infections, especially those of the respiratory tract, were associated with subsequent development of biopsy-confirmed GCA. Our findings support the hypothesis that a range of infections may trigger GCA. PMID: 32414956 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 18, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Do illness perceptions and coping strategies change over time in patients recently diagnosed with axial spondyloarthritis?
CONCLUSION: Whilst back pain, disease activity, and health outcomes clearly improved over 2 years, illness perceptions and coping strategies remained remarkably stable. PMID: 32414957 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 18, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Increased prevalence of Lupus Co-morbidity in Patients with Psoriatic Arthritis: A Population-Based Case-Controlled Study.
CONCLUSION: A 2.3fold increase in the prevalence of SLE in PsA relative to control group was found. Risk factors for SLE development included older age at PsA diagnosis, shorter PsA duration, and statin treatment. The association between PsA and SLE may affect treatment choices and medication development. PMID: 32414958 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - May 18, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.
CONCLUSION: We found that the average patient receiving treatment with hydroxychloroquine for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 in-vitro. Nevertheless, patients receiving hydroxychloroquine long-term may have tissue concentrations far exceeding that of serum/plasma. Because the therapeutic window for hydroxychloroquine in the setting of SARS-CoV-2 is unknown, well-designed clinical trials that include patients with rheumatic disease are urgently needed to characterize the efficacy, safety, and tar...
Source: Journal of Rheumatology - May 14, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Calling All Rheumatologists!
Authors: Sandhu V Abstract These are difficult times. First responders are putting their lives at risk in order to save others'. But this is our profession; we chose to work in the healthcare industry, knowing our daily exposures to different people with diverse ailments. Nobody chose this profession thinking they would one day be part of a pandemic, fearing for their lives and those of their loved ones by proxy. PMID: 32265342 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 9, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Rheumatologist's Role in Covid-19.
Authors: Cron RQ, Chatham WW Abstract The novel coronavirus (SARS-CoV-2) pandemic has spread rapidly throughout the planet. It is believed to have originated in the Wuhan province of China, but this highly contagious respiratory virus has spread to over 140 countries on 6 continents as of mid-March 2020 according to the World Health Organization (WHO). Worldwide, there have been over 164,000 cases identified and over 6,500 deaths attributed to the viral infection. As of March 15, 2020, there are over 3,700 confirmed cases and 68 deaths ascribed to Covid-19 (the disease caused by SARS-CoV-2) in the United States [ht...
Source: Journal of Rheumatology - March 27, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Antinuclear Antibodies (ANA) Testing Method Variability: A Survey of Participants in the College of American Pathologists' (CAP) Proficiency Testing Program.
CONCLUSION: ANA methodology and practice and test naming and reporting varies significantly between laboratories. Lack of uniformity in testing and reporting practice and lack of transparency in communicating the testing method may misdirect clinicians in their management of patients. PMID: 32173652 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research