Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.
CONCLUSION: We found that the average patient receiving treatment with hydroxychloroquine for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 in-vitro. Nevertheless, patients receiving hydroxychloroquine long-term may have tissue concentrations far exceeding that of serum/plasma. Because the therapeutic window for hydroxychloroquine in the setting of SARS-CoV-2 is unknown, well-designed clinical trials that include patients with rheumatic disease are urgently needed to characterize the efficacy, safety, and tar...
Source: Journal of Rheumatology - May 14, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Calling All Rheumatologists!
Authors: Sandhu V Abstract These are difficult times. First responders are putting their lives at risk in order to save others'. But this is our profession; we chose to work in the healthcare industry, knowing our daily exposures to different people with diverse ailments. Nobody chose this profession thinking they would one day be part of a pandemic, fearing for their lives and those of their loved ones by proxy. PMID: 32265342 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 9, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Rheumatologist's Role in Covid-19.
Authors: Cron RQ, Chatham WW Abstract The novel coronavirus (SARS-CoV-2) pandemic has spread rapidly throughout the planet. It is believed to have originated in the Wuhan province of China, but this highly contagious respiratory virus has spread to over 140 countries on 6 continents as of mid-March 2020 according to the World Health Organization (WHO). Worldwide, there have been over 164,000 cases identified and over 6,500 deaths attributed to the viral infection. As of March 15, 2020, there are over 3,700 confirmed cases and 68 deaths ascribed to Covid-19 (the disease caused by SARS-CoV-2) in the United States [ht...
Source: Journal of Rheumatology - March 27, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Antinuclear Antibodies (ANA) Testing Method Variability: A Survey of Participants in the College of American Pathologists' (CAP) Proficiency Testing Program.
CONCLUSION: ANA methodology and practice and test naming and reporting varies significantly between laboratories. Lack of uniformity in testing and reporting practice and lack of transparency in communicating the testing method may misdirect clinicians in their management of patients. PMID: 32173652 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Not every picture tells a story: a content analysis of visual images in patient educational resources about gout.
CONCLUSION: Key concepts about gout and treatment are under-represented in the images used in educational resources for patients. A large proportion of the images do not convey useful information about gout or its management. PMID: 32173653 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Rituximab and Cyclophosphamide in anti-synthetase syndrome (ASyS)-related ILD: an observational retrospective study.
CONCLUSION: Despite similar PFS at 6 months, RTX was associated with a better 2-year PFS compared to CYC in patients with ASyS-related ILD. PMID: 32173654 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The challenge of Very Early Systemic Sclerosis: a Combination of Mild and Early Disease?
CONCLUSION: This study showed that patients with very early SSc are a mixture of patients with mild or early disease. This needs to be considered in clinical practice for risk stratification and for the study design of patients considered as early SSc. PMID: 32173655 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Enthesitis-related arthritis: prevalence and complications of associated uveitis in children and adolescents from a population-based nation-wide study in Germany.
CONCLUSION: The course of disease in ERA-U patients is frequently similar to HLAB27-associated uveitis in adults; however, a subgroup of patients presents with asymptomatic uveitis. PMID: 32173656 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Analysis of anti-RNA polymerase III antibody positive systemic sclerosis suggests altered GPATCH2L and CTNND2 expression in scleroderma renal crisis.
CONCLUSION: Increased expression of two candidate proteins GPATCH2L and CTNND2 in SRC compared with control kidney suggests a potential role in pathogenesis of SRC. For GPATCH2L this may reflect genetic susceptibility in ARA positive SSc based upon 2 independent cohorts. PMID: 32173657 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Five-year evolution patterns of physical activity and sedentary behavior in patients with lower-limb osteoarthritis and their sociodemographic and clinical correlates.
Authors: Bitar S, Omorou AY, Van Hoye A, Guillemin F, Rat AC Abstract OBJECTIVE: The present study aimed to identify trajectories of physical activity (PA) components (frequency, duration, intensity, type) and screen-based sedentary behavior (SB) as well as baseline predictors of each trajectory in patients with hip and/or knee OA. METHODS: We included 878 patients with a 5-year follow-up from the KHOALA cohort. PA and SB were measured by the Modifiable Activity Questionnaire. We used group-based trajectory analysis to identify the trajectories of PA components and screen-based SB, and multivariable logistic re...
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Association of an Increasing Waist Circumference and Risk of Incident Low Physical Function in Adults with Knee Osteoarthritis.
Authors: Christiansen MB, Thoma LM, Master H, Voinier D, White DK Abstract OBJECTIVE: To investigate an eight-year change in waist circumference (WC) with the risk of incident low physical function over one-year in adults with or at risk of knee osteoarthritis (OA). METHODS: Data from the Osteoarthritis Initiative (OAI) were used. Change in WC was measured from study enrollment (0-month) to the 96-month visit and classified as Increase (≥ 5cm gain) or Maintain (
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Correlation of a Modified Disease Activity Score with the Validated Original Disease Activity Score in Patients with Juvenile Dermatomyositis.
This study's objective was to determine if our DASmod correlates with the validated DAS in patients with JDM. METHODS: In this study, we used DASmod (scored 0-12) and DAS scores (scored 0-20) for patients with JDM in our clinic. We analysed the correlation between the DASmod and the validated DAS. RESULTS: For 51 patients seen in our JDM clinic, the median (IQR) DASmod score was 2.0 (0, 4.0) and the median (IQR) DAS score was 3.0 (0, 5.5). Scores on the two tools were highly positively correlated (r = 0.94, p
Source: Journal of Rheumatology - March 17, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Serum microRNA signature as a diagnostic and therapeutic marker in patients with psoriatic arthritis.
Authors: Wade SM, McGarry T, Wade SC, Fearon U, Veale DJ Abstract OBJECTIVE: MicroRNAs (miRNAs) are small endogenous regulatory RNA molecules, which have emerged as potential therapeutic targets and biomarkers in autoimmunity. Here, we investigated serum miRNA levels in Psoriatic arthritis (PsA) patients and further assessed a serum miRNA signature in therapeutic responder versus non-responder PsA patients. METHODS: Serum samples were collected from healthy controls (n=20) and PsA (n=31) and clinical demographics obtained. To examine circulatory miRNA in serum from HC and PsA patients a focussed immunology miRN...
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Association of Poverty Income Ratio with Physical Functioning in a Cohort of Patients with Systemic Lupus Erythematosus.
Authors: Hoge C, Bowling CB, Lim SS, Drenkard C, Plantinga L Abstract OBJECTIVE: To examine the association of income relative to the poverty threshold [poverty income ratio (PIR)] with self-reported physical functioning in a cohort of systemic lupus erythematosus patients. METHODS: We used cross-sectional data on 744 participants from Georgians Organized Against Lupus (GOAL), and secondary analyses used data on 56 participants from a nested pilot study. Primary analyses utilized multivariable linear regression to estimate the association between PIR (categorized as
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Psychological and pain sensitisation characteristics are associated with patellofemoral osteoarthritis symptoms: The Multicenter Osteoarthritis Study.
CONCLUSION: Persons with PFOA symptoms, regardless of MRI PFOA status, are more likely to demonstrate depressive symptoms, catastrophizing and TS. Males with PFOA symptoms without MRI PFOA demonstrate local hyperalgesia. PMID: 32115429 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Epidemiology of depression and anxiety in gout: A systematic review and metaanalysis.
CONCLUSION: Our systematic review suggests depression and anxiety are significantly associated with gout and highlights the need for future research to focus on the onset of mental disorders after gout diagnosis as well as identify potential targets for intervention. PMID: 32115430 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

To Lump or Split When Assessing Psoriatic Arthritis - Not Mutually Exclusive?
Authors: Tillett W, Helliwell P PMID: 32115431 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

With Minor Salivary Gland Biopsy in Sj ögren Syndrome, Is a Negative Result Possible?
With Minor Salivary Gland Biopsy in Sjögren Syndrome, Is a Negative Result Possible? J Rheumatol. 2020 Mar;47(3):310-312 Authors: Monsalve DM, Anaya JM PMID: 32115432 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Predictors of Success in Gout Treatment.
Authors: Day RO, Coleshill MJ, Stocker SL, Nguyen AD, Robinson P, Aung E PMID: 32115433 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Graft-versus-host Disease Complicated by Sequential Septic Arthritis and Osteomyelitis.
Authors: Miller JB, McCARTHY EF, Gelber AC PMID: 32115434 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Metaanalyses, Network Metaanalyses, and Systematic Reviews: The Perpetual Motion Machine All Over Again.
Authors: Yazici Y PMID: 31894089 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - January 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Is Remission a Valid Target for Gout?
Authors: Pascual E, Andrés M, Sivera F PMID: 31894090 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - January 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Tunnel Vision in a Patient with Polymyalgia Rheumatica.
Authors: Milchert M, Brzosko M PMID: 31894091 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - January 3, 2020 Category: Rheumatology Tags: J Rheumatol Source Type: research

Mortality among patients with giant-cell arteritis: A large-scale population-based cohort study.
CONCLUSION: GCA patients have a minor decrease in long-term survival compared to age-andsex-matched controls. The seen difference is due to excess mortality in the first 2 years, and>10 years after diagnosis. Patients diagnosed ≤70 years of age are at greater risk. PMID: 31839591 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 17, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Neutrophil extracellular traps identify patients at risk of increased disease activity and cardiovascular comorbidity in systemic lupus erythematosus.
Authors: Moore S, Juo HH, Nielsen CT, Tyden H, Bengtsson AA, Lood C Abstract OBJECTIVE: Neutrophil extracellular traps (NETs) are essential in host defense, but are also linked to inflammation and autoimmunity, including systemic lupus erythematosus (SLE). We recently described that immune complexes (ICs) induce NET formation, promoting lupus-like disease in mice. In the current study, we investigated, for the first time, the role of NETs in human SLE and their association with disease activity and severity. METHODS: Levels of NETs (MPO-DNA complexes) were analyzed in plasma from four crosssectional SLE cohorts...
Source: Journal of Rheumatology - December 17, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Large Vessel Vasculitis Affecting the Aorta and Its Branches in Relapsing Polychondritis: Case Series and Systematic Review of the Literature.
CONCLUSION: Extra-aortic LVV is a serious and overlooked RP manifestation. All RP patients should be investigated for LVV. PMID: 31839593 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 17, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Association between Vitamin D deficiency and disease activity, disability and radiographic progression in early rheumatoid arthritis. The ESPOIR cohort.
Authors: Mouterde G, Gamon E, Rincheval N, Lukas C, Seror R, Berenbaum F, Dupuy AM, Daien C, Daurès JP, Combe B Abstract OBJECTIVE: To evaluate the association of baseline serum level of vitamin D (vitD) with disease activity, disability and radiographic damage over the first year in early rheumatoid arthritis (RA). METHODS: Among early arthritis patients included in the ESPOIR cohort, patients with early RA were evaluated. 25OH vitamin D2D3 level was measured at baseline. Baseline associations between vitD level and DAS28-ESR, Health Assessment Questionnaire Disability Index (HAQ-DI) and van der Heijde-...
Source: Journal of Rheumatology - December 17, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Scope of outcomes in trials and observational studies of interventions targeting medication adherence in rheumatic conditions: a systematic review.
CONCLUSION: The outcome domains and adherence measures in interventional studies targeting adherence are heterogeneous. Consensus on relevant outcomes will improve the comparison of different strategies to support medication adherence in rheumatology. PMID: 31839595 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 17, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Toward the Estimation of Unbiased Disease Prevalence Estimates Using Administrative Health Records.
Authors: Falasinnu T, Simard JF PMID: 31787592 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Musculotendinous Inflammation: The Defining Pathology of Polymyalgia Rheumatica?
Authors: Owen CE, Liew DFL, Buchanan RRC PMID: 31787593 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Hydroxychloroquine Ocular Toxicity: Lessons Learned.
Authors: Rabin JC, Ramirez K PMID: 31787594 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment.
Authors: PMID: 31787595 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Reviewer Index.
Authors: PMID: 31787596 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Soluble Isoform of CTLA-4 Correlates with Interferon- α Activity in Systemic Lupus Erythematosus.
The Soluble Isoform of CTLA-4 Correlates with Interferon-α Activity in Systemic Lupus Erythematosus. J Rheumatol. 2019 Dec 01;: Authors: Dahal LN, Barker RN, Ward FJ Abstract Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder characterized by fluctuating levels of immune response hyperactivity, high serum titers of nucleic antigen-specific autoantibodies, and persistent production of type-I interferon (IFN)1 One route to controlling SLE has been to exploit the properties of T cell lymphocyte costimulation inhibitor (CTLA-4), a selective costimulation inhibitor, which suppress...
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Spectrum and prognosis of ANCA-associated vasculitis-related bronchiectasis: data from 61 patients.
CONCLUSION: The association of bronchiectasis with AAV is likely not fortuitous and is mostly associated with MPO-ANCA. Patients in whom bronchiectasis precedes the onset of AAV tend to have distinct clinical and biological features and could carry a worse prognosis. PMID: 31787599 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

The Risk of Diabetes Mellitus in Patients with Juvenile Idiopathic Arthritis.
CONCLUSION: JIA appears to be associated with an increased risk of T1D compared to asthma and healthy children. PMID: 31787600 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Health-related quality of life in patients with hand osteoarthritis from the general population and the outpatient clinic.
CONCLUSION: Hand osteoarthritis was associated with reduced physical, but not mental HRQoL in the general population and hospital patients. Physical HRQoL was further reduced in hospital care, and with concurrent knee osteoarthritis. PMID: 31787601 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

The neuropathic pain features in Psoriatic Arthritis: a cross-sectional evaluation of prevalence and associated factors.
Authors: Di Carlo M, Muto P, Benfaremo D, Luchetti MM, Atzeni F, Salaffi F Abstract OBJECTIVE: To evaluate the prevalence and factors associated with the neuropathic pain features in a cohort of patients with psoriatic arthritis (PsA). METHODS: A cross-sectional evaluation was conducted in consecutive patients suffering from PsA with prevalent peripheral joint involvement, referring to three rheumatological centers. For each patient a comprehensive assessment of disease activity, physical function, and disease impact was carried out. The presence of comorbid fibromyalgia syndrome (FMS) was evaluated. Acute phas...
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Menopause and Possible Effect on Association Between Age and Anticyclic Citrullinated Peptide Antibodies in Women At Risk of Rheumatoid Arthritis.
Authors: Alpizar-Rodriguez D, Finckh A Abstract We read with interest the article by Berens, et al 1 reporting that increasing age was associated with positivity for anticyclic citrullinated peptide antibodies (anti-CCP) 3.1 and anti-CCP-IgA in individuals at risk of rheumatoid arthritis (RA), that is, first-degree relatives (FDR) of patients with RA. We found similar results in a Swiss cohort of FDR: anticitrullinated protein antibodies (ACPA) positivity, particularly anti-CCP3.1, was associated with older age2 However, in contrast to Berens, et al 1, we found a peak in prevalence in the age group of 45 to 55 year...
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Pain and self-reported swollen joints are main drivers of patient-reported flares in rheumatoid arthritis. Results from a 12-months' observational study.
Authors: Kuettel D, Primdahl J, Weber U, Terslev L, Østergaard M, Petersen R, Pedersen AK, Möller S, Hørslev-Petersen K Abstract OBJECTIVE: To examine prospectively self-reported flare characteristics and their longitudinal association with disease activity and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA). METHODS: Consecutive RA patients with DAS28CRP
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Reasons for b/tsDMARD cessation and persistence of second line treatment in a large real world rheumatoid arthritis dataset.
CONCLUSION: A large proportion of patients who stopped first-line TNFi therapy received another TNFi despite evidence for longer treatment persistence on second-line b/tsDMARDs with a different mode of action. Lack of efficacy was recorded as the most common reason for making a switch in first-line treatment of RA patients. PMID: 31787605 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

When has a knee or hip replacement failed? A patient perspective.
CONCLUSION: Lack of relief of pain or restoration of function or quality of life or the occurrence of surgical complications after TJR were defined as TJR failure by participants. Functional TJR failure seems as or more important than surgical failure. This patient perspective of TJR failure further confirmed their inclusion in core domain set for TJR clinical trials in people undergoing knee or hip replacements. PMID: 31787606 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Standardizing the clinical orofacial examination in Juvenile idiopathic arthritis: An interdisciplinary, consensus-based, short screening protocol.
Authors: Stoustrup P, Herlin T, Spiegel L, Rahimi H, Koos B, Pedersen TK, Twilt M, Temporomandibular joint Juvenile Arthritis Work group (TMJaw) Abstract OBJECTIVE: To develop a consensus-based, standardized, short clinical (
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Current smoking is increased in axial psoriatic arthritis and radiographic sacroiliitis.
Authors: Solmaz D, Kalyoncu U, Tinazzi I, Bakirci S, Bayindir O, Dogru A, Dalkilic E, Kimyon G, Ozisler C, Cetin GY, Kilic L, Omma A, Can M, Yilmaz S, Erden A, Aydin SZ Abstract OBJECTIVE: The effect of smoking in psoriatic arthritis (PsA) is controversial. Our aim was to test if smoking is increased in axial PsA (axPsA). METHODS: 1535 patients from PsArt-ID (PsA-International Database) were included in the analysis. The effect of smoking on axPsA (compared to other PsA phenotypes) and radiographic sacroiliitis were investigated. RESULTS: Current smoking was more common in axPsA (28.6% vs 18.9%, p
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Drs. Deane and Demoruelle reply.
Authors: Deane KD, Demoruelle MK Abstract In the letter by Alpizar-Rodriguez and Finckh1, they describe their prior work in which they found, similar to our current report, an association between older age and anticitrullinated protein antibody (ACPA) positivity in first-degree relatives (FDR) of patients with rheumatoid arthritis (RA)2,3 In contrast to our findings, their data suggest that the strongest association between ACPA positivity and age is in women aged 45-55 years, and they did not find an association between ACPA positivity and age in men. PMID: 31787609 [PubMed - as supplied by publisher] (Source:...
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

How Are Rheumatologists Managing Anticyclic Citrullinated Peptide Antibodies-positive Patients Who Do Not Have Arthritis?
Authors: Mankia K, Briggs C, Emery P Abstract Early referral and initiation of disease-modifying antirheumatic drugs (DMARD) is associated with better outcomes for patients with rheumatoid arthritis (RA)1,2 In the United Kingdom, general practitioners (GP) are advised to refer patients with suspected RA urgently3 and rheumatology departments are rewarded for timely management of these patients4. PMID: 31787610 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Association Between Cigarette Smoking and Systemic Lupus Erythematosus - an Updated Multivariate Bayesian Metaanalysis.
CONCLUSION: Current-smoking status is associated with the risk of SLE. Gender and the age of SLE patients had no significant impact on the risk of SLE over time. PMID: 31787611 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - December 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

TMA: Tell Me About It!
Authors: Bajema IM, Chua JS, Bruijn JA PMID: 31676544 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Psoriatic Arthritis, Psoriatic Disease, or Psoriatic Syndrome?
Authors: Lubrano E, Scriffignano S, Perrotta FM PMID: 31676545 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research

Amyloid Arthropathy: A Rare Mimic of Rheumatic Disease.
Authors: Bowie D, Bardi M, Hemmati I PMID: 31676546 [PubMed - in process] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - November 4, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research