Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease
Am J Physiol Renal Physiol. 2024 May 2. doi: 10.1152/ajprenal.00383.2023. Online ahead of print.ABSTRACTAccording to the Developmental Origins of Health and Disease (DOHaD) hypothesis, exposure to certain environmental influences during early life may be a key determinant of fetal development and short- and long-term offspring health. Indeed, adverse conditions encountered during the fetal, perinatal, and early childhood stages can alter normal development and growth, as well as put the offspring at elevated risk of developing long-term health conditions in adulthood, including chronic kidney disease (CKD) and cardiovascul...
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Zo é Oulerich Amanda N Sferruzzi-Perri Source Type: research
Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy
In this study, the preventive effects of the VASH2-targeting peptide vaccine against glomerular injury were examined in a streptozotocin (STZ)-induced diabetic mouse model. The mice were subcutaneously injected with the vaccine at two doses 2 weeks apart and then intraperitoneally injected with 50 mg/kg STZ for 5 consecutive days. Glomerular injury was evaluated 20 weeks after the first vaccination. Treatment with the VASH2-targeting peptide vaccine successfully induced circulating anti-VASH2 antibody without inflammation in major organs. Although the vaccination did not affect blood glucose levels, it significantly preven...
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Yuri Nakashima Katsuyuki Tanabe Tomoyo Mifune Takato Nakadoi Hiroki Hayashi Hironori Nakagami Yasufumi Sato Jun Wada Source Type: research
From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes
Expert Rev Endocrinol Metab. 2024 May 1:1-11. doi: 10.1080/17446651.2024.2347263. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.AREAS COVERED: The last two decades of experience have show...
Source: Expert Review of Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Asef Azad Hasan Ali Altunbas Ayse Esra Manguoglu Source Type: research
Effect of Virtual Versus In Person Interpreting on Diabetes Outcomes in Non-English Language Preference Patients: A Pilot Study
CONCLUSIONS: Quality medical interpretation contributes to optimal health outcomes in NELP patients with diabetes. Our study suggests that both in person and virtual interpreters can be effective in providing care for NELP patients, especially for chronic disease management in the context of a primary care relationship. It also highlights the importance of pursuing additional qualitative and mixed method studies to better understand the benefits of various interpreter formats across different visit types.PMID:38695439 | DOI:10.1177/21501319241240347 (Source: Primary Care)
Source: Primary Care - May 2, 2024 Category: Primary Care Authors: Marvin So Hailie Jadoo Jennifer Stong Kristen C Klemenhagen Ann M Philbrick Kathryn Freeman Source Type: research
Self-initiated lifestyle changes during a fasting-mimicking diet programme in patients with type 2 diabetes: a mixed-methods study
CONCLUSIONS: Using an FMD for five consecutive days per month did not affect diet quality in between FMD periods in quantitative analysis, but increased the number of hours per week spent on physical activity. Qualitative analysis revealed self-initiated improvements in both diet quality and physical activity in individual participants using an FMD. Healthcare professionals could use an FMD programme as a 'teachable moment' to stimulate additional lifestyle changes.TRIAL REGISTRATION: ClinicalTrials.gov; NCT03811587. Registered 22 January 2019.PMID:38698355 | DOI:10.1186/s12875-024-02405-5 (Source: Primary Care)
Source: Primary Care - May 2, 2024 Category: Primary Care Authors: Elske L van den Burg Marjolein P Schoonakker Bregje Korpershoek Lara E Sommeling Carlijn A Sturm Hildo J Lamb Hanno Pijl Mattijs E Numans Marieke A Adriaanse Petra G van Peet Source Type: research
Learning demands of diabetes self-management: a qualitative study with people who use insulin
CONCLUSION: the perception of the severity of the disease, its complications and the benefits of adhering to treatment positively influences adherence to self-care behaviors. Although the study participants have lived with diabetes for many years, they are not exempt from difficulties related to insulin use and disease management, reinforcing the importance of continuing health education. In this sense, the findings of this study guide important educational themes to be worked on by health professionals to promote autonomy in diabetes self-management.BACKGROUND: (1) Perceived severity of diabetes positively influences self...
Source: Revista Latino-Americana de Enfermagem - May 2, 2024 Category: Nursing Authors: Carla Assad Lemos Ana Maria Rosa Freato Gon çalves Elisabeth Meloni Vieira Leonardo R égis Leira Pereira Source Type: research
Metformin for endometrial hyperplasia
CONCLUSIONS: Review authors found insufficient evidence to either support or refute the use of metformin, specifically megestrol acetate, given alone or in combination with standard therapy, for the treatment of women with endometrial hyperplasia. Robustly designed and adequately powered randomised controlled trials, yielding long-term outcome data are still needed to address this clinical question.PMID:38695827 | DOI:10.1002/14651858.CD012214.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Hunain Shiwani Naomi S Clement Jane P Daniels William Atiomo Source Type: research
Syndecans and diabetic complications: a narrative review
Am J Med Sci. 2024 Apr 30:S0002-9629(24)01210-2. doi: 10.1016/j.amjms.2024.04.017. Online ahead of print.ABSTRACTSyndecan (SDC) is a member of the heparan sulfate proteoglycan (HSPG) family. It appears to play a role in the aetiology of diabetic complications, with decreased levels of SDCs being reported in the kidney, retina, and cardiac muscle in models of diabetes mellitus (DM). The reduced levels of SDCs may play an important role in the development of albuminuria in DM. Some studies have provided the evidence supporting the mechanisms underlying the role of SDCs in DM. However, SDCs and the molecular mechanisms involv...
Source: The American Journal of the Medical Sciences - May 2, 2024 Category: General Medicine Authors: Yasamin Rajabloo Maryam Saberi-Karimian Sara Saffar Soflaei Gordon A Ferns Majid Ghayour-Mobarhan Source Type: research
Risk Assessment of Diabetes Mellitus during and after Pregnancy in Women with Prolactinomas
CONCLUSIONS: Low PRL levels before pregnancy may be detrimental to FG during pregnancy. CAB duration and dose may influence long-term glucose tolerance, besides family history and BMI. Pre-conceptional metabolic management should be recommended to reduce the risk of gestational and type 2 diabetes mellitus.PMID:38693775 | DOI:10.1210/clinem/dgae289 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Roberta Scairati Renata S Auriemma Sara Di Meglio Guendalina Del Vecchio Rosa Pirchio Chiara Graziadio Claudia Pivonello Rosario Pivonello Annamaria Colao Source Type: research
Improvement of β-Cell Function After Switching From DPP-4 Inhibitors to Oral Semaglutide: SWITCH-SEMA2 Post Hoc Analysis
CONCLUSION: Switching to oral semaglutide ameliorated β-cell function compared with DPP-4is, presumably via tissue-to-tissue crosstalk between liver and β-cells.PMID:38695547 | DOI:10.1210/clinem/dgae213 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Hiroshi Nomoto Sho Furusawa Hiroki Yokoyama Yuka Suzuki Rimi Izumihara Yuki Oe Kiyohiko Takahashi Aika Miya Hiraku Kameda Kyu Yong Cho Jun Takeuchi Yoshio Kurihara Akinobu Nakamura Tatsuya Atsumi Source Type: research
Beneficial Effects of PIN1 Inhibition on Diabetes Mellitus: A Concise Review
Endocr Metab Immune Disord Drug Targets. 2024 Apr 30. doi: 10.2174/0118715303297663240307060019. Online ahead of print.ABSTRACTType 2 diabetes mellitus is a long-term medical illness in which the body either becomes resistant to insulin or fails to produce it sufficiently. Mostly, combinatorial therapy is required to control blood glucose levels. However, combinatorial therapy has detrimental side effects. The prevalence of the cases and subsequent increases in medical costs of the same intimidate human health globally. While there have been a lot of studies focused on developing diabetic regimens that work to lower blood ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2024 Category: Endocrinology Authors: Meeramol C Chellappan V Soumya Shriraam Mahadevan M K Kathiravan J Saravanan Soniya Naik Source Type: research
Disentangling fetal insulin hypersecretion and insulin resistance
Trends Endocrinol Metab. 2024 May 1:S1043-2760(24)00091-2. doi: 10.1016/j.tem.2024.04.008. Online ahead of print.ABSTRACTDisentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.PMID:38697899 | DOI:10.1016/j.tem.2024.04.008 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - May 2, 2024 Category: Endocrinology Authors: Christopher J Nolan Gernot Desoye Source Type: research
Pancreatic islet adaptation in pregnancy and postpartum
Trends Endocrinol Metab. 2024 May 1:S1043-2760(24)00090-0. doi: 10.1016/j.tem.2024.04.007. Online ahead of print.ABSTRACTPancreatic islets, particularly insulin-producing β-cells, are central regulators of glucose homeostasis capable of responding to a variety of metabolic stressors. Pregnancy is a unique physiological stressor, necessitating the islets to adapt to the complex interplay of maternal and fetal-placental factors influencing the metabolic milieu. In this review we highlight studies defining gestational adaptation mechanisms within maternal islets and emerging studies revealing islet adaptations during the ear...
Source: Trends in Endocrinology and Metabolism: TEM - May 2, 2024 Category: Endocrinology Authors: Nelmari Ruiz-Otero Jeffery S Tessem Ronadip R Banerjee Source Type: research
Diabulimia and Type 1 Diabetes: An Unknown and Emerging Problem
CONCLUSION: T1DM patients need to pay great attention to food quality and quantity; hence, an eating disorder diagnosis may be challenging. Additionally, there are currently no standard screening methods for this purpose. In our experience, an integrated approach is fundamental and may be a valid strategy to face this emerging problem.PMID:38693738 | DOI:10.2174/0118715303314948240419060714 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - May 2, 2024 Category: Endocrinology Authors: Benedetta Rivolta Benedetta Masserini Irene Bernardi Antonella Camera Federico Libo à Sebastiano Bruno Solerte Chiara Cerabolini Nadia Cerutti Source Type: research
Utilizing network pharmacology, molecular docking, and animal models to explore the therapeutic potential of the WenYang FuYuan recipe for cerebral ischemia-reperfusion injury through AGE-RAGE and NF- κB/p38MAPK signaling pathway modulation
CONCLUSION: This study utilized network pharmacology, molecular docking, and animal experiments to identify the potential mechanism of the WenYang FuYuan recipe, which may be associated with the regulation of the AGE-RAGE signaling pathway and the inhibition of target proteins and mRNAs in the downstream NF-kB/p38MAPK pathway.PMID:38697555 | DOI:10.1016/j.exger.2024.112448 (Source: Experimental Gerontology)
Source: Experimental Gerontology - May 2, 2024 Category: Geriatrics Authors: Ding Zhang Hongling Qin Wei Chen Junjun Xiang Minghe Jiang Ling Zhang Keqing Zhou Yueqiang Hu Source Type: research
