Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
Evaluating the efficacy and safety of therapeutic interventions for corneal neuropathy: A systematic review
Ocul Surf. 2024 Apr 28:S1542-0124(24)00050-8. doi: 10.1016/j.jtos.2024.04.004. Online ahead of print.ABSTRACTCorneal neuropathy involves corneal nerve damage that disrupts ocular surface integrity, negatively impacting quality-of-life from pain and impaired vision. Any ocular or systemic condition that damages the trigeminal nerve can lead to corneal neuropathy. However, the condition currently does not have standardized diagnostic criteria or treatment protocols. The primary aim of this systematic review was to evaluate the efficacy and safety of interventions for treating corneal neuropathy. Randomized controlled trials ...
Source: The Ocular Surface - April 30, 2024 Category: Opthalmology Authors: Rajni Rajan Eve Makrai Ji-Hyun Lee Sumeer Singh Holly R Chinnery Laura E Downie Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | PMC:PMC11058340 | DOI:10.3346/jkms.2024.39.e140 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 30, 2024 Category: General Medicine Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
Bioequivalence of Related GelShield < sup > Ⓡ < /sup > Sustained-Release Formulations of Metformin: A Pooled Pharmacokinetic Analysis
Clin Ther. 2024 Apr 29:S0149-2918(24)00077-8. doi: 10.1016/j.clinthera.2024.03.011. Online ahead of print.ABSTRACTPURPOSE: GlucophageⓇ (Merck Healthcare KGaA, Darmstadt, Germany) is the originator brand of metformin hydrochloride, an oral antidiabetic drug. Metformin is recommended in guidelines as first-line treatment of type 2 diabetes mellitus and increasingly in related insulin-resistant conditions, such as prediabetes and polycystic ovary syndrome. The GelShieldⓇ sustained-release formulation tablet of GlucophageⓇ has been improved from the historic version marketed in 2000. Bioequivalence has been demonstrated ...
Source: Clinical Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Axel Krebs-Brown Kerstin M G Brand Marco A F Nogueira Filho Sumedh Gaikwad Yvonne Schnaars Source Type: research
Does Serum Uric Acid to Creatinine Ratio Predict Mortality Risk in Patients With Heart Failure?
CONCLUSION: A high SUA/Cr ratio was an independent risk factor for the mortality risk of HF.PMID:38686683 | DOI:10.14503/THIJ-23-8210 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - April 30, 2024 Category: Cardiology Authors: Xiaoqing Xi Jinfeng Cai Chen Zhang Xuefei Wang Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Glycemic and lipid control in patients with diabetes at time of myocardial infarction
CONCLUSION: We highlighted the poor glycemic and lipid control in high-risk CV patients. There is an urgent need to develop multidisciplinary approaches to optimize CV risk factors control to reduce myocardial infarction and strokes.PMID:38685473 | DOI:10.1016/j.pharma.2024.04.010 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 30, 2024 Category: Drugs & Pharmacology Authors: Christelle Lacqua H éloïse Adam Marianne Zeller Lucie Vadot Florence Bichat Maud Maza Yves Cottin Mathieu Boulin Source Type: research
Relationship between effective blood flow rate and clinical outcomes in maintenance hemodialysis patients: a single-center study
Ren Fail. 2024 Dec;46(1):2344655. doi: 10.1080/0886022X.2024.2344655. Epub 2024 Apr 29.ABSTRACTThe association between blood flow rate (BFR) and clinical outcomes in patients undergoing maintenance hemodialysis (MHD) is inconclusive. This retrospective study included 175 patients undergoing MHD treatment between July 2015 and March 2022, divided into two groups based on time-averaged effective blood flow rate (eBFR) median value. We investigated arteriovenous fistula (AVF) outcomes and the association of eBFR with all-cause mortality and new major adverse cardiovascular events (MACE). Mean ± SD and median time-averaged eB...
Source: Renal Failure - April 30, 2024 Category: Urology & Nephrology Authors: Zhoucang Zhang Jiarui Li Jiaxiang Ding Shenglei Zhang Mei Wang Jinsheng Xu Source Type: research
Construction and Validation Study of a Model for Predicting the Risk of Pulmonary Complications in Elderly Patients with Multiple Rib Fractures
CONCLUSIONS: The column-line diagram model of pulmonary complications in patients with MRF constructed in this study showed good discriminative and calibration performance in both internal and external validation, which is helpful for clinicians to identify individuals at high risk of pulmonary complications as early as possible, and thus can be recommended for clinical use.PMID:38687856 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Chenchen Yang Hengfa Ge Aifeng Gong Source Type: research
Albiflorin Inhibits Advanced Glycation End Products-Induced ROS and MMP-1 Expression in Gingival Fibroblasts
CONCLUSION: Albiflorin exhibited protective effects against AGEs-induced oxidative stress and inflammation in gingival fibroblasts, highlighting its potential as a therapeutic agent for periodontitis in diabetic patients. The modulation of the NF-κB and Nrf2 pathways by albiflorin provides insight into its mechanism of action.PMID:38685787 | DOI:10.2174/011574888X302174240420165019 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 30, 2024 Category: Stem Cells Authors: Linlin Gao Wenqi Fu Yanyan Liu Lili Fan Shiwei Liu Nan Zhang Source Type: research
Construction of Risk Prediction Model of Type 2 Diabetic Kidney Disease Based on Deep Learning
CONCLUSION: The developed DKD risk predictive model using LSTM neural networks demonstrated high accuracy and AUC value. When HbA1c, SBP, and PP variabilities were added to the model as featured characteristics, the model's performance was greatly improved.PMID:38685670 | DOI:10.4093/dmj.2023.0033 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 30, 2024 Category: Endocrinology Authors: Chuan Yun Fangli Tang Zhenxiu Gao Wenjun Wang Fang Bai Joshua D Miller Huanhuan Liu Yaujiunn Lee Qingqing Lou Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | PMC:PMC11058340 | DOI:10.3346/jkms.2024.39.e140 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 30, 2024 Category: Biomedical Science Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
Hospital-Acquired Acute Kidney Injury in Non-Critical Medical Patients in a Developing Country Tertiary Hospital: Incidence and Predictors
CONCLUSION: HAAKI is a common complication in hospitalized non-critical medical patients, and is associated with a common medical condition and commonly prescribed medications. Therefore, it is important to remain vigilant in the prevention and timely identification of these cases and to establish a system of rational prescribing habits.PMID:38685967 | PMC:PMC11057508 | DOI:10.2147/IJNRD.S454987 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 30, 2024 Category: Urology & Nephrology Authors: Nahom Dessalegn Mekonnen Tigist Workneh Leulseged Buure Ayderuss Hassen Kidus Haile Yemaneberhan Helen Surafeal Berhe Nebiat Adane Mera Anteneh Abera Beyene Lidiya Zenebe Getachew Birukti Gebreyohannes Habtezgi Feven Negasi Abriha Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
