Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism.
Authors: Lee Y, Lee HY Abstract Over a hundred billion bacteria are found in human intestines. This has emerged as an environmental factor in metabolic diseases, such as obesity and related diseases. The majority of these bacteria belong to two dominant phyla, Bacteroidetes and Firmicutes. Since the ratio of Firmicutes to Bacteroidetes increases in people with obesity and in various animal models, it has been assumed that phylum composition causes the increase in occurrence of metabolic diseases over the past decade. However, this assumption has been challenged by recent studies that have found even an opposite ass...
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Diabetic Retinopathy and Related Clinical Practice for People with Diabetes in Korea: A 10-Year Trend Analysis.
Authors: Chung YR, Ha KH, Lee K, Kim DJ Abstract We performed a retrospective cohort study including people diagnosed with diabetes from 2006 to 2015 according to the Korean National Health Insurance Service-National Sample Cohort database, to analyze the changes in the prevalence, screening rate, and treatment patterns for diabetic retinopathy (DR) over 10 years. The proportion of people who underwent fundus screening for DR steadily increased over the past decade. The prevalence of DR increased from 13.4% in 2006 to 15.9% in 2015, while that of proliferative DR steadily decreased from 1.29% in 2006 to 1.16% in 20...
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus.
Authors: Baek JH, Lee WJ, Lee BW, Kim SK, Kim G, Jin SM, Kim JH Abstract BACKGROUND: The aim of this study was to evaluate characteristics and risk of diabetic complications according to age at diagnosis among young adults with type 1 diabetes mellitus (T1DM). METHODS: A total of 255 T1DM patients aged less than 40 years were included. Patients were categorized into three groups (
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Preserved Renal Function.
CONCLUSION: A high level of serum A-FABP is associated with an increased risk of rapid renal function decline in patients with T2DM and preserved renal function. This suggests that A-FABP could play a role in the progression of DKD in the early stages. PMID: 32662255 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effect of Sarcopenia and Body Shape on Cardiovascular Disease According to Obesity Phenotypes.
This study aimed to assess the effects of sarcopenia and A Body Shape Index (ABSI) on cardiovascular disease (CVD) risk according to obesity phenotypes. METHODS: We used data from the National Health and Nutrition Examination Survey 1999 to 2012. A total of 25,270 adults were included and classified into the following groups: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO). Sarcopenia was defined as the appendicular skeletal mass index
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell.
CONCLUSION: UC-MSC-CM improves insulin resistance with multiple mechanisms in C2C12 cell. PMID: 32662257 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus.
CONCLUSION: Our study report, for the first time, a profile of differentially expressed plasma circRNAs in new onset T1DM. Further in silico annotations and bioinformatics analyses supported future application of circRNAs as novel biomarkers of T1DM. PMID: 32662258 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 16, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Role of Growth Differentiation Factor 15 in Energy Metabolism.
Authors: Chang JY, Hong HJ, Kang SG, Kim JT, Zhang BY, Shong M Abstract Growth differentiation factor 15 (GDF15) is receiving great interest beyond its role as an aging and disease-related biomarker. Recent discovery of its receptor, glial cell line-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL), suggests a central role in appetite regulation. However, there is also considerable evidence that GDF15 may have peripheral activity through an as-of-yet undiscovered mode of action. This raises the question as to whether increased GDF15 induction during pathophysiologic conditions also suppresses ...
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective.
This report provides insight into the association between diabetes and COVID-19, proper management of diabetes in patients with COVID-19 and an official suggestion by the Korean Diabetes Association for managing the COVID-19 outbreak. PMID: 32613777 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Smoking as a Target for Prevention of Diabetes.
Authors: Yang YS, Sohn TS PMID: 32613778 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports (Diabetes Metab J 2020;44:349-53).
Authors: Jeon JY PMID: 32613779 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus (Diabetes Metab J 2020;44:267-76).
Authors: Yu SH PMID: 32613780 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports (Diabetes Metab J 2020;44:349-53).
Authors: Kim NY, Ha E, Moon JS, Lee YH, Choi EY PMID: 32613781 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus (Diabetes Metab J 2020;44:267-76).
Authors: Lee H, Kim G, Lee YH PMID: 32613782 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 4, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study.
Authors: Chung SM, Lee YY, Ha E, Yoon JS, Won KC, Lee HW, Hur J, Hong KS, Jang JG, Jin HJ, Choi EY, Shin KC, Chung JH, Lee KH, Ahn JH, Moon JS Abstract BACKGROUND: To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. METHODS: This was a retrospective cohort study of 117 confirmed patients with COVID-19 which conducted at a tertiary hospital in Daegu, South Korea. The primary outcome was defined as the severe and critical...
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study.
Authors: Lee SH, Min KW, Lee BW, Jeong IK, Yoo SJ, Kwon HS, Choi YH, Yoon KH Abstract BACKGROUND: Glycemic variability is associated with the development of diabetic complications and hypoglycemia. However, the effect of sodium-glucose transporter 2 (SGLT2) inhibitors on glycemic variability is controversial. We aimed to examine the effect of dapagliflozin as an add-on therapy to insulin on the glycemic variability assessed using continuous glucose monitoring (CGM) in subjects with type 2 diabetes mellitus. METHODS: In this multicenter, placebo-controlled, double-blind, randomized study, 84 subjects received 10...
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Importance of Awareness and Treatment for Diabetes in Influenza Vaccination Coverage of Diabetic Patients under 65 Years: A Population-Based Study.
CONCLUSION: Influenza vaccination rate was low in diabetic patients under 65 years, especially in those with unawareness and not getting treated for diabetes. Active screening and treatment for diabetes may be helpful to improve the influenza vaccination rate in these patients. PMID: 32602274 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Enhancer-Gene Interaction Analyses Identified the Epidermal Growth Factor Receptor as a Susceptibility Gene for Type 2 Diabetes Mellitus.
CONCLUSION: Genetic interaction analyses of enhancers and protein-coding genes suggested that EGFR may be a novel susceptibility gene for T2DM. PMID: 32602275 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Persistent Anxiety Is Associated with Higher Glycemia Post-Transition to Adult Services in Asian Young Adults with Diabetes.
Authors: Zhu L, Chandran SR, Tan WB, Xin X, Goh SY, Gardner DSL Abstract BACKGROUND: There is little longitudinal information on psychological burden and metabolic outcomes in young adults with diabetes (YAD) in Asia. We aimed to evaluate the association between psychological status and glycemia at baseline and 2 years following transition in a cohort of YAD in Singapore. METHODS: Subjects with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), aged 17 to 25 years, were recruited from the YAD clinic in Singapore General Hospital. The Hospital Anxiety and Depression and Problem Areas for Diabet...
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice.
CONCLUSION: We concluded that vimentin deficiency prevents obesity and insulin resistance in mice fed an HFD and suggest vimentin as a central mediator linking obesity and type 2 diabetes mellitus. PMID: 32602277 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats.
In this study, the effect of metformin on peripheral nerves in diabetic rats was investigated using diverse neuronal parameters of nerve fibers. METHODS: Rats were assigned to one of four groups (n=7 to 10 per group): normal, diabetes mellitus (DM), DM+metformin (100 mg/kg), and DM+alpha lipoic acid (ALA, 100 mg/kg). DM was induced by streptozotocin/high-fat diet (STZ/HFD). After 12 weeks, the sensory thresholds to mechanical and heat stimuli were assessed. Repeated sensory tests, immunofluorescence microscopic comparison of peripheral nerves, and biochemical blood analysis were performed after 24 weeks. RESULTS: B...
Source: Diabetes and Metabolism Journal - July 2, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo.
CONCLUSION: The present results indicate that voglibose would be metabolized by the intestinal microbiota, and that this metabolism might be pharmacodynamically critical in lowering blood glucose levels in mice. PMID: 32431100 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

A Comparison of Predictive Performances between Old versus New Criteria in a Risk-Based Screening Strategy for Gestational Diabetes Mellitus.
Authors: Hong S, Lee SM, Kwak SH, Kim BJ, Koo JN, Oh IH, Oh S, Kim SM, Shin S, Kim W, Joo SK, Norwitz ER, Louangsenlath S, Park CW, Jun JK, Park JS Abstract BACKGROUND: The definition of the high-risk group for gestational diabetes mellitus (GDM) defined by the American College of Obstetricians and Gynecologists was changed from the criteria composed of five historic/demographic factors (old criteria) to the criteria consisting of 11 factors (new criteria) in 2017. To compare the predictive performances between these two sets of criteria. METHODS: This is a secondary analysis of a large prospective cohort study...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between the Thigh Muscle and Insulin Resistance According to Body Mass Index in Middle-Aged Korean Adults.
We examined the associations between thigh muscle area (TMA) and insulin resistance (IR) according to body mass index (BMI) in middle-aged Korean general population. METHODS: TMA was measured using quantitative computed tomography and corrected by body weight (TMA/Wt) in 1,263 men, 788 premenopausal women, and 1,476 postmenopausal women all aged 30 to 64 years. The tertiles of TMA/Wt were calculated separately for men and for premenopausal and postmenopausal women. Homeostatic model assessment for insulin resistance (HOMA-IR) was performed using fasting blood glucose and insulin levels, and increased IR was defined acc...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort.
CONCLUSION: Snoring is associated with impaired glucose metabolism even in otherwise metabolically healthy adults. Habitual snorers may require lifestyle modifications and pharmacological treatment to improve glycemic profile. PMID: 32431103 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Association between Pulmonary Functions and Incident Diabetes: Longitudinal Analysis from the Ansung Cohort in Korea.
CONCLUSION: FVC and FEV₁ are independent risk factors for developing diabetes in Koreans. Pulmonary factors are possible risk factors for insulin resistance and diabetes. PMID: 32431104 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults.
CONCLUSION: Our findings provide sex-, age-, and disease-specific reference values to improve risk prediction and diagnostic performance for inflammatory diseases in both population- and clinic-based settings. PMID: 32431105 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Clinical Impact of Dysglycemia in Patients with an Acute Myocardial Infarction.
This study aimed to determine the impact of dysglycemia on myocardial injury and cardiac dysfunction in acute myocardial infarctions (AMIs). From 2005 to 2016, a total of 1,593 patients with AMIs who underwent percutaneous coronary intervention were enrolled. The patients were classified into five groups according to the admission glucose level: ≤80, 81 to 140, 141 to 200, 201 to 260, and ≥261 mg/dL. The clinical and echocardiographic parameters and 30-day mortality were analyzed. The peak troponin I and white blood cell levels had a positive linear relationship to the admission glucose level. The left ventricular ej...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women.
CONCLUSION: Increased insulin resistance is associated with total IgE and atopy in premenopausal women but not in postmenopausal women or men. PMID: 32431107 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Deterioration of Sleep Quality According to Glycemic Status.
CONCLUSION: Although the participants in the present study were not necessarily conscious of their sleep disturbances, deterioration in sleep quality progressed according to glycemic status. PMID: 32431108 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Associations among Obesity Degree, Glycemic Status, and Risk of Heart Failure in 9,720,220 Korean Adults.
In this study, we analyzed whether the risk of HF increases in participants according to baseline glycemic status and whether this increased risk is associated with obesity status. METHODS: We analyzed the risk of HF according to baseline glycemic status (normoglycemia, impaired fasting glucose [IFG], and diabetes) in 9,720,220 Koreans who underwent Korean National Health Screening in 2009 without HF at baseline with a median follow-up period of 6.3 years. The participants were divided into five and six groups according to baseline body mass index (BMI) and waist circumference, respectively. RESULTS: Participants w...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Differences in Clinical Outcomes between Patients with and without Hypoglycemia during Hospitalization: A Retrospective Study Using Real-World Evidence.
This study investigated risk factors for hypoglycemia and its effects on glycemic control during the hospitalization of patients in the general ward. METHODS: This retrospective study included patients who were admitted between 2009 and 2018. Patients were provided regular meals at fixed times according to ideal body weights during hospitalization. We categorized the patients into two groups: those with and those without hypoglycemia during hospitalization. RESULTS: Of the 3,031 patients, 379 experienced at least one episode of hypoglycemia during hospitalization (HYPO group). Hypoglycemia occurred more frequently ...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?
Authors: Rohde K, Schamarek I, Blüher M Abstract Premature obesity-related mortality is caused by cardiovascular and pulmonary diseases, type 2 diabetes mellitus, physical disabilities, osteoarthritis, and certain types of cancer. Obesity is caused by a positive energy balance due to hyper-caloric nutrition, low physical activity, and energy expenditure. Overeating is partially driven by impaired homeostatic feedback of the peripheral energy status in obesity. However, food with its different qualities is a key driver for the reward driven hedonic feeding with tremendous consequences on calorie consumption. In...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats.
CONCLUSION: Our study revealed that celastrol decreased the BW of obese rats by enhancing energy expenditure but not by suppressing food intake and that this effect was mediated by the improvement of the gut microbiota and the activation of the hypothalamic leptin signaling pathway. PMID: 32431112 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Hypoxia Increases β-Cell Death by Activating Pancreatic Stellate Cells within the Islet.
CONCLUSION: PSCs within the islet are activated in hypoxia through oxidative stress and promote islet cell death, suggesting that hypoxia-induced PSC activation may contribute to β-cell loss in type 2 diabetes mellitus. PMID: 32431113 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Metagenomic Analysis of the Gut Microbiome Reveals Enrichment of Menaquinones (Vitamin K2) Pathway in Diabetes Mellitus.
Authors: Dash NR, Al Bataineh MT Abstract BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with a high prevalence worldwide, especially among overweight and obese populations. T2DM is multifactorial with several genetic and acquired risk factors that lead to insulin resistance. Mounting evidence indicates that alteration of gut microbiome composition contribute to insulin resistance and inflammation. However, the precise link between T2DM and gut microbiome role and composition remains unknown. METHODS: We evaluated the metabolic capabilities of the gut microbiome of twelve T2DM and si...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association.
Authors: Lee BW, Lee YH, Park CY, Rhee EJ, Lee WY, Kim NH, Choi KM, Park KG, Choi YK, Cha BS, Lee DH, Korean Diabetes Association (KDA) Fatty Liver Research Group Abstract This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher...
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice.
CONCLUSION: Therefore, this study demonstrated that FGF21 might exert therapeutic effects on DN through AMPK-SIRT1 pathway. PMID: 32431116 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice.
CONCLUSION: MondoA appears to mediate mouse myofiber development, and MondoA decreases the muscle glycogen level. The findings indicate the potential function of MondoA in skeletal muscle, linking the glucose-related transcription factor to myogenesis and skeletal myofiber glycogen metabolism. PMID: 32431117 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 21, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Outbreak of COVID-19 and Diabetes in Korea: "We Will Find a Way as We Have Always Done".
The Outbreak of COVID-19 and Diabetes in Korea: "We Will Find a Way as We Have Always Done". Diabetes Metab J. 2020 04;44(2):211-212 Authors: Won KC, Yoon KH PMID: 32347022 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Fibrates Revisited: Potential Role in Cardiovascular Risk Reduction.
Authors: Kim NH, Kim SG Abstract Fibrates, peroxisome proliferator-activated receptor-α agonists, are potent lipid-modifying drugs. Their main effects are reduction of triglycerides and increase in high-density lipoprotein levels. Several randomized controlled trials have not demonstrated their benefits on cardiovascular risk reduction, especially as an "add on" to statin therapy. However, subsequent analyses by major clinical trials, meta-analyses, and real-world evidence have proposed their potential in specific patient populations with atherogenic dyslipidemia and metabolic syndrome. Here, we hav...
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond.
The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond. Diabetes Metab J. 2020 Apr;44(2):222-233 Authors: Moon JS, Karunakaran U, Suma E, Chung SM, Won KC Abstract Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. Glucotoxicity, lipotoxicity, and glucolipotoxicity have been suggested to be a major cause of β-cell dysfunction for deca...
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Histone Deacetylase 9: Its Role in the Pathogenesis of Diabetes and Other Chronic Diseases.
Authors: Hu S, Cho EH, Lee JY Abstract As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene transcription. The activity of HDAC9 is regulated transcriptionally and post-translationally. HDAC9 is known to play an essential role in regulating myocyte and adipocyte differentiation and cardiac muscle development. Also, recent studies have suggested that HDAC9 is involved in the pathogenesis of chronic diseases, including cardiovascular diseases, osteoporosis, autoimmune disease, cancer, obesity, in...
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Biomarker Score in Risk Prediction: Beyond Scientific Evidence and Statistical Performance.
Authors: Bang H PMID: 32347026 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports.
Authors: Kim NY, Ha E, Moon JS, Lee YH, Choi EY Abstract Since the first case was contracted by coronavirus disease-19 (COVID-19) in Daegu, Korea in February 2020, about 6,800 cases and 130 deaths have been reported on April 9, 2020. Recent studies have reported that patients with diabetes showed higher mortality and they had a worse prognosis than the group without diabetes. In poorly controlled patients with diabetes, acute hyperglycemic crises such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS) also might be precipitated by COVID-19. Thus, intensive monitoring and aggressive supportive ...
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: An Electronic Health Record-Integrated Computerized Intravenous Insulin Infusion Protocol: Clinical Outcomes and in Silico Adjustment (Diabetes Metab J 2020;44:56-66).
Authors: Yi D PMID: 32347028 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125-33).
Authors: Kim JH PMID: 32347029 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: An Electronic Health Record-Integrated Computerized Intravenous Insulin Infusion Protocol: Clinical Outcomes and in Silico Adjustment (Diabetes Metab J 2020;44:56-66).
Authors: Park SW, Lee S, Cha WC, Hur KY, Kim JH, Lee MK, Park SM, Jin SM PMID: 32347030 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125-33).
Authors: Han SJ PMID: 32347031 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - May 1, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Can Habitual Exercise Help Reduce Serum Concentrations of Lipophilic Chemical Mixtures? Association between Physical Activity and Persistent Organic Pollutants.
Authors: Lee YM, Shin JY, Kim SA, Jacobs DR, Lee DH Abstract BACKGROUND: Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs), have emerged as a new risk factor of many chronic diseases. As serum concentrations of POPs in humans are mainly determined by both their release from adipose tissue to circulation and their elimination from circulation, management of these internal pathways may be important in controlling the serum concentrations of POPs. As habitual physical activity can increase the elimination of POPs from circulation, we evaluated whether chronic physical activity ...
Source: Diabetes and Metabolism Journal - March 18, 2020 Category: Endocrinology Tags: Diabetes Metab J Source Type: research