Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome.
CONCLUSION: Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease. PMID: 29885102 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Serum Soluble Epidermal Growth Factor Receptor Level Increase in Patients Newly Diagnosed with Type 2 Diabetes Mellitus.
Authors: Kim JM, Choung S, Joung KH, Lee JH, Kim HJ, Ku BJ Abstract We analyzed circulating soluble epidermal growth factor receptor (sEGFR) levels in humans. Serum sEGFR levels were higher in subjects with newly diagnosed type 2 diabetes mellitus compared with controls. Serum sEGFR was positively correlated with glycosylated hemoglobin and serum glucose and negatively correlated with serum insulin and C-peptide levels. PMID: 29885103 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Glycated Albumin Is a More Useful Glycation Index than HbA1c for Reflecting Renal Tubulopathy in Subjects with Early Diabetic Kidney Disease.
CONCLUSION: GA is a more useful glycation index than HbA1c for reflecting renal tubulopathy in subjects with T2DM with normoalbuminuria and normal eGFR. PMID: 29885104 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Insulin Resistance and the Risk of Diabetes and Dysglycemia in Korean General Adult Population.
CONCLUSION: Insulin resistance is closely associated with the risk for T2DM/dysglycemia. The accuracy of HOMA-IR levels is characterized by sex- and age-specific differences in identifying T2DM. In addition to insulin resistance index, insulin secretory function, and different MetS components should be considered in the detection of early T2DM, especially in elderly. PMID: 29885105 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats.
Authors: Koothappan M, Vellai RD, Subramanian IP, Subramanian SP Abstract Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesi...
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance.
CONCLUSION: Short-term inhibition of serotonin synthesis prevented hepatic lipid accumulation without affecting systemic insulin sensitivity and energy expenditure, suggesting the direct steatogenic effect of serotonin in liver. PMID: 29885107 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats.
Authors: Lee KA, Jin HY, Lee NY, Kim YJ, Park TS Abstract The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

10-Year Mortality Trends for Adults with and without Diabetes Mellitus in South Korea, 2003 to 2013.
Authors: Kim KJ, Kwon TY, Yu S, Seo JA, Kim NH, Choi KM, Baik SH, Choi DS, Kim SG, Park Y, Kim NH Abstract BACKGROUND: To estimate and compare the trends of all-cause and cause-specific mortality rates for subjects with and without diabetes in South Korea, from 2003 to 2013. METHODS: Using a population-based cohort (2003 to 2013), we evaluated annual mortality rates in adults (≥30 years) with and without diabetes. The number of subjects in this analysis ranged from 585,795 in 2003 to 670,020 in 2013. RESULTS: Age- and sex-adjusted all-cause mortality rates decreased consistently in both groups from 2003 ...
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Role of Advanced Glycation End Products in Diabetic Vascular Complications.
Authors: Rhee SY, Kim YS Abstract In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications. PMID: 29885110 ...
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Evidence for an Obesity Paradox in Type 2 Diabetes Mellitus.
Authors: Han SJ, Boyko EJ Abstract Although overweight/obesity is a major risk factor for the development of type 2 diabetes mellitus, there is increasing evidence that overweight or obese patients with type 2 diabetes mellitus experience lower mortality compared with patients of normal weight. This paradoxical finding, known as the "obesity paradox," occurs in other chronic diseases, and in type 2 diabetes mellitus is particularly perplexing given that lifestyle intervention with one goal being weight reduction is an important feature of the management of this condition. We summarize in this review the f...
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Higher Prevalence and Progression Rate of Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus.
Authors: Kim KS, Park SW, Cho YW, Kim SK Abstract BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Predictors of Incident Type 2 Diabetes Mellitus in Japanese Americans with Normal Fasting Glucose Level.
CONCLUSION: A substantial number of subjects with NFG at baseline still remained in the NFG range at the time of diabetes diagnosis. A family history of diabetes and fasting insulin and glucose levels were associated with diabetes diagnosis during 10 years of follow-up; however, fasting glucose level was not associated with diabetes risk within the relatively short-term follow-up period of 5 years in subjects with NFG. PMID: 29885113 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Air Pollution Has a Significant Negative Impact on Intentional Efforts to Lose Weight: A Global Scale Analysis.
Authors: Ustulin M, Park SY, Chin SO, Chon S, Woo JT, Rhee SY Abstract BACKGROUND: Air pollution causes many diseases and deaths. It is important to see how air pollution affects obesity, which is common worldwide. Therefore, we analyzed data from a smartphone application for intentional weight loss, and then we validated them. METHODS: Our analysis was structured in two parts. We analyzed data from a cohort registered to a smartphone application in 10 large cities of the world and matched it with the annual pollution values. We validated these results using daily pollution data in United States and matching th...
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Changes of Trends in the Diagnosis and Treatment of Diabetic Foot Ulcer over a 10-Year Period: Single Center Study.
CONCLUSION: Improved glycemic control, multidisciplinary strategies with prompt surgical treatment resulted in reduced length of hospital stay, but these measures did not reduce major LEAs. The increase in critical ischemic limb may have played a role in the unexpected outcome, and may suggest the need for increased vascular intervention strategies in DFU treatment. PMID: 29885115 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 11, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis.
Authors: Ko SH, Han K, Lee YH, Noh J, Park CY, Kim DJ, Jung CH, Lee KU, Ko KS, TaskForce Team for the Diabetes Fact Sheet of the Korean Diabetes Association Abstract Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general ...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals. METHODS: We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health Organization Clinical Trial Registry Platform, and Clinicaltrial.gov Registry from inception to August 1, 2017 for randomized controlled trials. Pooled effects of interventions were assessed as mean difference using random effects model. We conducted a sensitivity, publication bias and subgroup analysis. RESULTS...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Primary Cilia as a Signaling Platform for Control of Energy Metabolism.
Authors: Song DK, Choi JH, Kim MS Abstract Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, ...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Insulin Resistance versus β-Cell Failure: Is It Changing in Koreans?
Insulin Resistance versus β-Cell Failure: Is It Changing in Koreans? Diabetes Metab J. 2018 Apr;42(2):128-129 Authors: Kim MK PMID: 29676542 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index.
Authors: Ha KH, Park CY, Jeong IK, Kim HJ, Kim SY, Kim WJ, Yoon JS, Kim IJ, Kim DJ, Kim S Abstract BACKGROUND: We evaluated the clinical characteristics of insulin resistance and β-cell dysfunction in newly diagnosed, drug-naive people with type 2 diabetes by analyzing nationwide cross-sectional data. METHODS: We collected the clinical data of 912 participants with newly diagnosed diabetes from 83 primary care clinics and hospitals nationwide from 2015 to 2016. The presence of insulin resistance and β-cell dysfunction was defined as a homeostatic model assessment of insulin resistance (HOMA-IR) value ...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Clinical Implications of Using Post-Challenge Plasma Glucose Levels for Early Diagnosis of Type 2 Diabetes Mellitus in Older Individuals.
Authors: Joung KH, Ju SH, Kim JM, Choung S, Lee JM, Park KS, Kim HJ, Ku BJ Abstract BACKGROUND: The aim of this study was to explore the differences in the clinical characteristics and diagnostic rates of diabetes mellitus (DM) according to various criteria in different age groups and to evaluate the efficacy of each criterion for screening older patients. METHODS: We studied 515 patients and measured the fasting plasma glucose level (FPG), 2-hour plasma glucose level after the 75 g oral glucose tolerance test (2-hour postload glucose [2-h PG]), and glycosylated hemoglobin (HbA1c) for re-evaluation of hyperglyc...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Hemorheologic Alterations in Patients with Type 2 Diabetes Mellitus Presented with an Acute Myocardial Infarction.
Authors: Park KH, Kim U, Choi KU, Nam JH, Lee JH, Lee CH, Son JW, Park JS, Shin DG, Won KC, Moon JS, Kim YK, Suh JS Abstract BACKGROUND: Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells.
In this study, we, demonstrated, for the first time in the literature, that encapsulation of murine pancreatic islet cells with Al-CA hydrogel does not induce cytotoxicity ex vivo for an extended period; however, it does markedly abate glucose-stimulated insulin secretion. Catechol should not be considered as a constituent for alginate gelation for encapsulating islet cells in the application of islet transplantation. PMID: 29676546 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Morphologic Comparison of Peripheral Nerves in Adipocyte Tissue from db/db Diabetic versus Normal Mice.
Authors: Lee KA, Lee NY, Park TS, Jin HY Abstract Present study investigated the morphologic changes of autonomic nerves in the adipose tissue in diabetic animal model. Male obese type 2 diabetic db/db mice and age matched non-diabetic db/m control mice were used. Epididymal adipose tissue from diabetic db/db mice with that from control heterozygous db/m mice was compared using confocal microscopy-based method to visualize intact whole adipose tissue. Immunohistochemistry with tyrosine hydroxylase for sympathetic (SP), choline acetyltransferase for parasympathetic (PSP), and protein gene product 9.5 (PGP 9.5) for w...
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Patient Understanding of Hypoglycemia in Tertiary Referral Centers (Diabetes Metab J 2018;42:43-52).
Authors: Jeon JH PMID: 29676548 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Patient Understanding of Hypoglycemia in Tertiary Referral Centers (Diabetes Metab J 2018;42:43-52).
Authors: Cho NH, Kim HS PMID: 29676549 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Corrigendum: Table and Text Correction. Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians.
Authors: Iqbal A, Novodvorsky P, Heller SR Abstract This corrects the article on p. 3 in vol. 42, PMID: 29504302. PMID: 29676550 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 22, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

A Short but Long Journey with You.
Authors: Won KC PMID: 29504301 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Recent Updates on Type 1 Diabetes Mellitus Management for Clinicians.
Authors: Iqbal A, Novodvorsky P, Heller SR Abstract Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition that requires life-long administration of insulin. Optimal management of T1DM entails a good knowledge and understanding of this condition both by the physician and the patient. Recent introduction of novel insulin preparations, technological advances in insulin delivery and glucose monitoring, such as continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring and improved understanding of the detrimental effects of hypoglycaemia and hyperglycaemia offer new opportunities and ...
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Being Metabolically Healthy, the Most Responsible Factor for Vascular Health.
Authors: Rhee EJ Abstract The prevalence of obesity is rapidly increasing worldwide. One-thirds of world population is suffering from the deleterious effects of excessive fat and adipose tissue in their body. At the same time, the average life expectancy is becoming higher and higher every decade. Therefore, living healthy and longer is the dream for everyone. Simply being obese is not the primary cause for the consequence of obesity; rather, the depot where the fat is accumulated, is the primary key for the deleterious effects of obesity. Results from historical research suggest that visceral fat increases the ris...
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Self-Monitoring of Blood Glucose in Patients with Insulin-Treated Type 2 Diabetes Mellitus.
Authors: Kim KS PMID: 29504304 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Patient Understanding of Hypoglycemia in Tertiary Referral Centers.
CONCLUSION: Many patients had experienced hypoglycemia and worried about it. We recommend identifying patients that are anxious about hypoglycemia and educating them about what to do when they develop hypoglycemic symptoms, especially those who have a high risk of hypoglycemia. PMID: 29504305 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Color Doppler Ultrasonography Is a Useful Tool for Diagnosis of Peripheral Artery Disease in Type 2 Diabetes Mellitus Patients with Ankle-Brachial Index 0.91 to 1.40.
CONCLUSION: Color Doppler ultrasonography is a useful tool for the detection of PAD in T2DM patients with ABI 0.91 to 1.40 but a high CIMT. PMID: 29504306 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Lack of Evidence of the Role of APOA5 3'UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome.
CONCLUSION: These results presented no association of APOA5 3'UTR SNPs with MetS. Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group. PMID: 29504307 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Single Sensor Gait Analysis to Detect Diabetic Peripheral Neuropathy: A Proof of Principle Study.
This study explored the potential utility of gait analysis using a single sensor unit (inertial measurement unit [IMU]) as a simple tool to detect peripheral neuropathy in people with diabetes. Seventeen people (14 men) aged 63±9 years (mean±SD) with diabetic peripheral neuropathy performed a 10-m walk test instrumented with an IMU on the lower back. Compared to a reference healthy control data set (matched by gender, age, and body mass index) both spatiotemporal and gait control variables were different between groups, with walking speed, step time, and SDa (gait control parameter) demonstrating good discrim...
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65).
Authors: Ryu OH PMID: 29504309 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65).
Authors: Jeon EJ, Lee JH PMID: 29504310 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 6, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association.
Authors: Kim HJ, Park SO, Ko SH, Rhee SY, Hur KY, Kim NH, Moon MK, Lee BW, Kim JH, Choi KM, Committee of Clinical Practice Guidelines of the Korean Diabetes Association Abstract The glucagon-like peptide-1 receptor agonists (GLP-1RAs) were recommended as a monotherapy or combination therapy with oral hypoglycemic agents or basal insulin in the position statement of the Korean Diabetes Association 2017 for pharmacological therapy. Many randomized clinical trials and systematic reviews report that GLP-1RAs have considerable glucose-lowering effect and lead to weight reduction and low risk of hypoglycemia when used as...
Source: Diabetes and Metabolism Journal - December 23, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Simple Screening Using Ultrasonography for Prediction of Gestational Diabetes Mellitus.
Authors: Chung SM, Moon JS PMID: 29272082 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 23, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association of Self-Care Behaviors and Quality of Life among Patients with Type 2 Diabetes Mellitus: Chaldoran County, Iran.
CONCLUSION: Self-care behaviors were significantly associated with quality of life; among them, the greatest influence was observed in self-care nutrition behavior. According to the findings of this study, appropriate interventions on self-care behaviors about nutrition can improve the quality of life for T2DM patients. PMID: 29272083 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 23, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data (Diabetes Metab J 2017;41:393-404).
Authors: Yun JS PMID: 29272084 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 23, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data (Diabetes Metab J 2017;41:393-404).
Authors: Rhee SY, Woo JT PMID: 29272085 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 23, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Prediction of Gestational Diabetes Mellitus in Pregnant Korean Women Based on Abdominal Subcutaneous Fat Thickness as Measured by Ultrasonography.
This study was performed to verify the correlation between abdominal subcutaneous fat thickness (ASFT) measured by ultrasonography (US) during the first trimester of pregnancy and gestational diabetes mellitus (GDM) of the second trimester in Korean women and to establish a standard of ASFT for predicting GDM. METHODS: A total of 333 singleton pregnant women participated in this study. Their ASFT was measured by US during the 10⁺⁶ to 13⁺⁶ weeks of pregnancy; then a GDM confirmatory test (100 g oral glucose tolerance test) was conducted during the 24 to 28 week period of pregnancy. Based on the GDM tests, compar...
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Improvement of Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus under Insulin Treatment by Reimbursement for Self-Monitoring of Blood Glucose.
Authors: Song YS, Koo BK, Kim SW, Yi KH, Shin K, Moon MK Abstract BACKGROUND: In Korea, the costs associated with self-monitoring of blood glucose (SMBG) for patients with type 2 diabetes mellitus (T2DM) under insulin treatment have been reimbursed since November 2015. We investigated whether this new reimbursement program for SMBG has improved the glycemic control in the beneficiaries of this policy. METHODS: Among all adult T2DM patients with ≥3 months of reimbursement (n=854), subjects without any changes in anti-hyperglycemic agents during the study period were selected. The improvement of glycosylated h...
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Serum Betatrophin Concentrations and the Risk of Incident Diabetes: A Nested Case-Control Study from Chungju Metabolic Disease Cohort.
Authors: Lee SH, Rhee M, Kwon HS, Park YM, Yoon KH Abstract BACKGROUND: Betatrophin is a newly identified hormone derived from the liver and adipose tissue, which has been suggested to regulate glucose and lipid metabolism. Circulating levels of betatrophin are altered in various metabolic diseases, although the results are inconsistent. We aimed to examine whether betatrophin is a useful biomarker in predicting the development of diabetes. METHODS: A nested case-control study was performed using a prospective Chungju Metabolic disease Cohort Study. During a 4-year follow-up period, we analyzed 167 individuals ...
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Role of Negative Affect in the Assessment of Quality of Life among Women with Type 1 Diabetes Mellitus.
CONCLUSION: The recognition of negative affect presentations among patients, and an understanding of its relevance to diabetesrelated quality of life, is a valuable tool for the practitioner. PMID: 29199406 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus.
This study included 57 pregnant women who were diagnosed with GDM at 24 to 28 weeks of gestation. The subjects were classified into two or three groups according to pre-pregnancy body mass index (BMI,
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Beneficial Effects of Aerobic Exercise Training Combined with Rosiglitazone on Glucose Metabolism in Otsuka Long Evans Tokushima Fatty Rats.
CONCLUSION: Regular aerobic exercise combined with rosiglitazone treatment can compensate for the adverse effect of rosiglitazone treatment and has benefit for islet preservation. PMID: 29199408 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Depressive Symptoms Are Negatively Associated with Glucose Testing and Eating Meals on Time among Individuals with Diabetes in Zambia.
CONCLUSION: Some variance on poor self-care was explained by demographic characteristics, specifically age, body mass index, and to some extent, socioeconomic status. Recognition and successful treatment of depression in patients with diabetes might help to optimize self-care behaviors, especially glucose testing and eating meals on time. However, this hypothesis needs further testing. PMID: 29199409 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases.
Authors: Han E, Lee YH Abstract As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. N...
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Phospholipid Linoleoylglycerophosphocholine as a Biomarker of Directly Measured Insulin Resistance.
CONCLUSION: In our sample of Latino adults without known diabetes, LGPC showed potential as a biomarker of IR and impaired glucose metabolism. PMID: 29199411 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 6, 2017 Category: Endocrinology Tags: Diabetes Metab J Source Type: research