Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes.
This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 2,399 male participants of>20 years of age who were euthyroid and non-diabetic. Prediabetic participants had lower FT4 concentrations than those without prediabetes, but their thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, glycosylated he...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effects of Dapagliflozin on Endothelial Function, Renal Injury Markers, and Glycemic Control in Drug-Na ïve Patients with Type 2 Diabetes Mellitus.
CONCLUSION: Dapagliflozin treatment did not affect systemic endothelial function or renal injury markers except N-acetyl-beta-D-glucosaminidase. PMID: 30968615 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Relation between Baseline Height and New Diabetes Development: A Nationwide Population-Based Study.
Authors: Rhee EJ, Cho JH, Kwon H, Park SE, Jung JH, Han KD, Park YG, Kim YH, Lee WY Abstract BACKGROUND: Short stature and leg length are associated with risk of diabetes and obesity. However, it remains unclear whether this association is observed in Asians. We evaluated the association between short stature and increased risk for diabetes using the Korean National Health Screening (KNHS) dataset. METHODS: We assessed diabetes development in 2015 in 21,122,422 non-diabetic Koreans (mean age 43 years) enrolled in KNHS from 2009 to 2012 using International Classification of Diseases 10th (ICD-10) code and anti-d...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study.
CONCLUSION: There is a positive association between plasma fetuin-A levels and risk of developing T2DM in this Chinese population. PMID: 30968617 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation.
Authors: Woo CY, Jang JE, Lee SE, Koh EH, Lee KU Abstract Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study.
CONCLUSION: Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome. PMID: 30968619 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults.
This study was based on data obtained from the sixth Korea National Health and Nutrition Examination Survey, administered from 2013 to 2015. A total of 13,873 participants aged ≥19 years were included, and classified into four groups: metabolically healthy non-obesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), and metabolically unhealthy obesity (MUO) by body fat on the basis of body mass index and metabolic health. RESULTS: At baseline, serum free thyroxine (fT4) values were significantly higher in the MHNO phenotype (MHNO, 1.27±0.01 ng/mL; MHO, 1.25±0.01 ...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3.
CONCLUSION: PRMT1 critically contributes to pancreas development by destabilizing the NGN3 protein. PMID: 30968621 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Protective Effects of Increasing Serum Uric Acid Level on Development of Metabolic Syndrome.
Authors: Yu TY, Jin SM, Jee JH, Bae JC, Lee MK, Kim JH Abstract BACKGROUND: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects. METHODS: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with develop...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus.
CONCLUSION: Taken together, intact incretin levels are primarily related to C-peptide and glucose levels. This result suggests that glycemia and insulin secretion are the main factors associated with intact incretin levels in T2DM patients. PMID: 30877705 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus.
Authors: Huh JH, Ahn SG, Kim YI, Go T, Sung KC, Choi JH, Koh KK, Kim JY Abstract BACKGROUND: Metabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM. METHODS: We analyzed data from 7,317 participants aged 40 to 70 years without DM at baseline, who took part in 2001 to 2011 Korean Genome Epidemiology Study. Subjects were categorized into four groups based on repeated longitudinal assessment of MetS status over ...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study.
CONCLUSION: This population-based cohort study showed that the use of DPP4i as add-on therapy to metformin did not increase the risk of DR progression compared to SU. PMID: 30877707 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus.
CONCLUSIONS: Liver fibrosis was associated with LV diastolic dysfunction in patients with T2DM and may be an independent risk factor for diastolic dysfunction, especially in patients without systemic insulin resistance. PMID: 30877708 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Korean Patients with Type 2 Diabetes Mellitus in Real-World Clinical Practice.
This study aimed to evaluate the efficacy and safety of sodium-glucose cotransporter-2 (SGLT2) inhibitors in Korean patients who had inadequately controlled type 2 diabetes mellitus (T2DM) in real-world clinical practice. METHODS: We included 410 patients who started SGLT2 inhibitors (empagliflozin or dapagliflozin) as add-on therapy or switch therapy between February 2015 and June 2017. The primary efficacy endpoint was a change in glycosylated hemoglobin (HbA1c) from baseline to week 12. The secondary endpoints were patients achieving HbA1c
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests.
Authors: Kang S, Kim MH, Kim MY, Hong JS, Kwak SH, Choi SH, Lim S, Park KS, Jang HC Abstract BACKGROUND: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. METHODS: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) a...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.
CONCLUSION: The present study shows that activation of the NLRP3 inflammasome contributes to UUO-induced renal fibrosis and the renoprotective effect of gemigliptin is associated with attenuation of NLRP3 inflammasome activation. PMID: 30877711 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study.
CONCLUSION: Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings. PMID: 30877712 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria.
Authors: Kim MH, Kwak SH, Kim SH, Hong JS, Chung HR, Choi SH, Kim MY, Jang HC Abstract BACKGROUND: We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by the Carpenter-Coustan (CC) criteria. METHODS: A total of 8,735 Korean pregnant women were identified at two hospitals between 2014 and 2016. Among them, 2,038 women participated in the prospective cohort to investigate pregnancy outcomes. Diagnosis of GDM was made via two-step approach with 50-g glucose c...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Lower Leg Fat Depots Are Associated with Albuminuria Independently of Obesity, Insulin Resistance, and Metabolic Syndrome (Korea National Health and Nutrition Examination Surveys 2008 to 2011).
Authors: Han E, Cho NH, Kim MK, Kim HS Abstract BACKGROUND: Although the involvement of obesity in metabolic disorders is well known, leg fat depot influences on albuminuria have not been determined. METHODS: This population-based, cross-sectional study used a nationally representative sample of 2,076 subjects aged ≥20 years from the Korea National Health and Nutrition Examination Surveys of 2008 to 2011. The ratio of leg fat to total fat (LF/TF ratio) was assessed by dual X-ray absorptiometry, and albuminuria was defined as more than one positive dipstick test or an albumin-to-creatinine ratio of ≥30 mg/...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function.
Authors: Seo DH, Kim SH, Song JH, Hong S, Suh YJ, Ahn SH, Woo JT, Baik SH, Park Y, Lee KW, Kim YS, Nam M, KNDP Study Group Abstract BACKGROUND: Recent evidences indicate that early rapid renal function decline is closely associated with the development and progression of diabetic kidney disease. We have investigated the association between carotid atherosclerosis and rapid renal function decline in patients with type 2 diabetes mellitus and preserved renal function. METHODS: In a prospective, multicenter cohort, a total of 967 patients with type 2 diabetes mellitus and preserved renal function were followed for...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction?
CONCLUSION: Fasting measurements of glucose and C-peptide as well as the surrogate indices of glycemic condition could be used for stratifying pregnant females with higher risk of GDM at the beginning of pregnancy. PMID: 30877716 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

DMJ, Better than Yesterday, More Brilliant Tomorrow.
Authors: Won KC PMID: 30793548 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet.
Authors: Spallone V Abstract The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are on the table: by promoting screening for symptoms and signs; by ...
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis.
Authors: Lee YH, Cho Y, Lee BW, Park CY, Lee DH, Cha BS, Rhee EJ Abstract Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This recip...
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Concern about the Safety of Bisphenol A Substitutes.
Authors: Moon MK PMID: 30793551 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents.
CONCLUSION: This study for the first time showed that exposure to BPF, a commonly used substitute for BPA, was positively associated with higher risk of obesity in children and adolescents. The association of BPA and BPF with general and abdominal obesity was primarily observed in boys, suggesting a possible sex difference. Further investigations on the underlying mechanisms are needed. PMID: 30793552 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488-95).
Authors: Cho NH, Kim HS PMID: 30793553 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans (Diabetes Metab J 2018;42:488-95).
Authors: Han SJ, Boyko EJ Abstract PMID: 30793554 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies.
CONCLUSION: This meta-analysis demonstrates that high levels of Se are associated with the presence of DM. Further prospective and randomized controlled trials are warranted to elucidate the link better. PMID: 30688047 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 30, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus.
CONCLUSION: A 6-week combination therapy of low-dose rosuvastatin and ezetimibe showed LDL-C, apoB, and apoB/A1 ratio reduction comparable to that of high-dose rosuvastatin monotherapy in patients with type 2 diabetes mellitus. Triglyceride and FFA reductions were greater with the combination therapy than with rosuvastatin monotherapy. PMID: 30688048 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 30, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5.
CONCLUSION: Myricetin protects the β-cells against HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b. PMID: 30688049 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 30, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study.
Authors: Yoo SG, Han KD, Lee KH, La Y, Kwon DE, Han SH Abstract BACKGROUND: A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). METHODS: From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 million, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Dis...
Source: Diabetes and Metabolism Journal - January 30, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between Changes in Anthropometric Indices and in Fasting Insulin Levels among Healthy Korean Adolescents: The JS High School Study.
This study investigated the association between changes in anthropometric indices and fasting insulin levels among healthy adolescents and whether the association differed by baseline obesity status. METHODS: This analysis was based on data collected for the JS High School study; 884 healthy adolescents aged 15 to 16 years followed up for 24 to 30 months were included. Changes in anthropometric indices and fasting insulin levels were computed as the difference between baseline and follow-up values. Multivariate linear regression models were used to determine the association between changes in anthropometric indices and...
Source: Diabetes and Metabolism Journal - January 30, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors.
CONCLUSION: A better response to SGLT2 inhibitors is expected in Korean T2DM patients who have higher baseline HbA1c and eGFR with a shorter diabetes duration. Moreover, the add-on of an SGLT2 inhibitor to a DPP4 inhibitor is likely to show the greatest glycemic response. PMID: 30688052 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 30, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-methyl-D-aspartate Receptors.
CONCLUSION: We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats. PMID: 30604591 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis.
CONCLUSION: Exercise significantly improves glycemic control; however, it does not significantly reduce body weight. Aerobic training can be beneficial for patients with non-insulin-treated T2DM in Korea. PMID: 30604592 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Glycosylated Hemoglobin in Subjects Affected by Iron-Deficiency Anemia.
Authors: Intra J, Limonta G, Cappellini F, Bertona M, Brambilla P Abstract Previous studies have suggested that iron-deficiency anemia affects glycosylated hemoglobin (HbA1c) measurements, but the results were contradictory. We conducted a retrospective case-control study to determine the effects of iron deficiency on HbA1c levels. Starting with the large computerized database of the Italian Hospital of Desio, including data from 2000 to 2016, all non-pregnant individuals older than 12 years of age with at least one measurement of HbA1c, cell blood count, ferritin, and fasting blood glucose on the same date of bloo...
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.
Authors: Oh TJ, Yu JM, Min KW, Son HS, Lee MK, Yoon KH, Song YD, Park JY, Jeong IK, Cha BS, Kim YS, Baik SH, Kim IJ, Kim DM, Kim SR, Lee KW, Park JH, Lee IK, Park TS, Choi SH, Park SW Abstract BACKGROUND: Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect. We compared the efficacy and safety of a fixed-dose combination of voglibose plus metformin (vogmet) with metformin monotherapy in drug-naïve newly-diagnosed type 2 diabetes mellitus. METHODS: A total of 187 elig...
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Oral Glucose Tolerance Testing Allows Better Prediction of Diabetes in Women with a History of Gestational Diabetes Mellitus.
CONCLUSION: We identified a crucial role of β-cell dysfunction in the development of diabetes in Korean women with previous GDM. The 2-hour glucose result from the OGTT is an independent predictor of future diabetes. Therefore, the OGTT is crucial for better prediction of future diabetes in Korean women with previous GDM. PMID: 30604595 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Associations between Breastfeeding and Type 2 Diabetes Mellitus and Glycemic Control in Parous Women: A Nationwide, Population-Based Study.
Authors: Nam GE, Han K, Kim DH, Huh Y, Han B, Cho SJ, Park YG, Park YM Abstract We investigated associations between breastfeeding duration and number of children breastfed and type 2 diabetes mellitus (T2DM) and glycemic control among parous women. We performed a cross-sectional analysis of data for 9,960 parous women from the Korea National Health and Nutritional Examination Survey (2010 to 2013). Having ever breastfed was inversely associated with prevalent T2DM (adjusted odds ratio [OR], 0.60; 95% confidence interval [CI], 0.42 to 0.87). All ranges of total and average breastfeeding duration showed inverse asso...
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study.
CONCLUSION: WC had a significant linear relationship with the risk of MI and IS and the risk began to increase from a WC that was lower than expected. PMID: 30604597 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Asian Subpopulations May Exhibit Greater Cardiovascular Benefit from Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A Meta-Analysis of Cardiovascular Outcome Trials.
Authors: Kang YM, Cho YK, Lee J, Lee SE, Lee WJ, Park JY, Kim YJ, Jung CH, Nauck MA Abstract BACKGROUND: Based on reported results of three large cardiovascular outcome trials (CVOTs) of glucagon-like peptide 1 receptor agonists (GLP-1 RAs), we aimed to investigate the overall effect of GLP-1 RAs on major adverse cardiovascular events (MACEs) and to identify subpopulations exhibiting the greatest cardiovascular (CV) benefit. METHODS: Three CVOTs reporting effects of long-acting GLP-1 RAs were included: LEADER (liraglutide), SUSTAIN-6 (semaglutide), and EXSCEL (exenatide once weekly). In all studies, the primary...
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
Authors: Yang HK, Lee SH, Shin J, Choi YH, Ahn YB, Lee BW, Rhee EJ, Min KW, Yoon KH Abstract BACKGROUND: We evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin. METHODS: A total of 165 subjects were randomized to metformin and sitagliptin (Met+Sita, n=65), metformin, sitagliptin, and acarbose (Met+Sita+Acarb, n=66) and sitagliptin and acarbose (Sita+Acarb, exploratory assessment, n=34) therapy in five institutions in Korea. After 16 weeks of acarbose add-on or metformin-switch therapy,...
Source: Diabetes and Metabolism Journal - January 5, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management.
Authors: Pieralice S, Pozzilli P Abstract Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are initially insulin independent and recognizable only by testing for islet-cell autoantibodies, it could be difficult to identify LADA in clinical setting and a high misdiagnosis rate still remains among patients with T2DM. Ideally, islet-cell autoantibodies screenin...
Source: Diabetes and Metabolism Journal - December 21, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Is Diabetes & Metabolism Journal Eligible to Be Indexed in MEDLINE?
Is Diabetes & Metabolism Journal Eligible to Be Indexed in MEDLINE? Diabetes Metab J. 2018 Dec;42(6):472-474 Authors: Huh S PMID: 30565441 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 21, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Fifty Years of Compassionate Care and Harmonious Collaboration of the Korean Diabetes Association: The 50th Anniversary of Korean Diabetes Association.
Authors: Won JC, Rhee EJ, Yoo HJ PMID: 30565442 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 21, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: The Necessity of the Simple Tests for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients without Neuropathic Symptoms in Clinical Practice (Diabetes Metab J 2018;42:442-6).
Authors: Hong JH PMID: 30565443 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 21, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: The Necessity of the Simple Tests for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients without Neuropathic Symptoms in Clinical Practice (Diabetes Metab J 2018;42:442-6).
Authors: Park JH, Kim DS PMID: 30565444 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - December 21, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between Serum Cystatin C and Vascular Complications in Type 2 Diabetes Mellitus without Nephropathy.
This study aimed to evaluate if higher serum CysC levels increase the risk for vascular complications in type 2 diabetes mellitus patients with normal renal function or mild renal impairment. METHODS: A total of 806 consecutive patients with type 2 diabetes mellitus who were admitted to the diabetes center of Soonchunhyang University Hospital for blood glucose control were retrospectively reviewed. Patients with nephropathy were excluded. Subjects were categorized into quartiles of serum CysC levels (Q1, ≤0.65 mg/L; Q2, 0.66 to 0.79 mg/L; Q3, 0.80 to 0.94 mg/L; and Q4, ≥0.95 mg/L). RESULTS: The proportion of ...
Source: Diabetes and Metabolism Journal - November 8, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance.
CONCLUSION: This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown. PMID: 30398036 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - November 8, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research