Premeal Consumption of a Protein-Enriched, Dietary Fiber-Fortified Bar Decreases Total Energy Intake in Healthy Individuals.
CONCLUSION: In healthy individuals, a premeal supplementation of PFB reduced total energy intake and decreased postprandial glucose excursion. This finding necessitates long-term studies regarding clinical use in obesity. PMID: 31339008 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 25, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients.
In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic. PMID: 31339009 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 25, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action.
CONCLUSION: This study suggests that the action of metformin on β-cell lipotoxicity was implemented by different molecular pathways depending on its concentration. Metformin at a usual therapeutic dose is supposed to alleviate lipotoxic β-cell dysfunction through inhibition of oxidative stress and ER stress. PMID: 31339010 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - July 25, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study.
This study assessed the efficacy and safety of pioglitazone or glimepiride when added to metformin plus alogliptin treatment for T2DM. METHODS: This multicenter, randomized, active-controlled trial (ClinicalTrials.gov: NCT02426294) recruited 135 Korean patients with T2DM that was inadequately controlled using metformin plus alogliptin. The patients were then randomized to also receive pioglitazone (15 mg/day) or glimepiride (2 mg/day) for a 26-week period, with dose titration was permitted based on the investigator's judgement. RESULTS: Glycosylated hemoglobin levels exhibited similar significant decreases in both ...
Source: Diabetes and Metabolism Journal - July 25, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status.
This study used 2013 to 2016 data from the Korea National Health and Nutrition Examination Survey, a nationally-representative survey of the Korean population. Diabetes was defined as fasting glucose ≥126 mg/dL, current use of antidiabetic medication, a previous history of diabetes, or glycosylated hemoglobin (HbA1c) ≥6.5%. RESULTS: In 2016, 14.4% (approximately 5.02 million) of Korean adults had diabetes. The prevalence of impaired fasting glucose was 25.3% (8.71 million). From 2013 to 2016, the awareness, control, and treatment rates for diabetes were 62.6%, 56.7%, and 25.1%, respectively. People with diabetes ...
Source: Diabetes and Metabolism Journal - July 25, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Longitudinal Changes of Body Composition Phenotypes and Their Association with Incident Type 2 Diabetes Mellitus during a 5-Year Follow-up in Koreans.
CONCLUSION: Maintenance of ASM may be protective against the development of type 2 diabetes mellitus in men, regardless of obesity status. PMID: 31237125 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Additional Effect of Dietary Fiber in Patients with Type 2 Diabetes Mellitus Using Metformin and Sulfonylurea: An Open-Label, Pilot Trial.
CONCLUSION: While dietary fiber did not induce additional changes in glycemic parameters, it showed a trend of improvement in insulin sensitivity in 'responders.' Even if patients are already receiving diabetes treatment, the additional administration of fiber can lead to additional benefits in the treatment of diabetes. PMID: 31237126 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy.
CONCLUSION: Our results indicate that G-CSF might have an anti-apoptotic effect through down-regulation of miR-34a in a diabetic cardiomyopathy rat model. PMID: 31237127 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice.
CONCLUSION: Low frequency IH exposure impaired adipogenesis of SAT in lean mice, and macrophage polarization may be a potential mechanism for the impaired adipogenesis. PMID: 31237128 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between Change in Alcohol Consumption and Metabolic Syndrome: Analysis from the Health Examinees Study.
Authors: Choi S, Kim K, Lee JK, Choi JY, Shin A, Park SK, Kang D, Park SM Abstract BACKGROUND: The association between change in alcohol intake and metabolic syndrome is unclear. METHODS: This retrospective cohort consisted of 41,368 males and females from the Health Examinees-GEM study. Participants were divided into non-drinkers (0.0 g/day), light drinkers (male: 0.1 to 19.9 g/day; female: 0.1 to 9.9 g/day), moderate drinkers (male: 20.0 to 39.9 g/day; female: 10.0 to 19.9 g/day), and heavy drinkers (male: ≥40.0 g/day; female: ≥20.0 g/day) for each of the initial and follow-up health examinations. Logis...
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Association between Z-Score of Log-Transformed A Body Shape Index and Cardiovascular Disease in Korea.
In this study, we analyzed the relationship between the LBSIZ and cardiovascular disease (CVD) in a Korean representative sample. METHODS: Data were collected from the Korea National Health and Nutrition Examination VI to V. The association between CVD and obesity indices was analyzed using a receiver operating characteristic curve. The cut-off value for the LBSIZ was estimated using the Youden index, and the odds ratio (OR) for CVD was determined via multivariate logistic regression analysis. ORs according to the LBSIZ value were analyzed using restricted cubic spline regression plots. RESULTS: A total of 31,227 K...
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model.
Authors: Park I, Hong S, Hwang Y, Kim P Abstract Longitudinal imaging of murine pancreas is technically challenging due to the mechanical softness of the tissue influenced by peristalsis. Here, we report a novel pancreatic imaging window for long-term stabilized cellular-level observation of the islets in the pancreas in vivo. By spatially separating the pancreas from the bowel movement and physiologic respiration with a metal plate integrated in the imaging window, we successfully tracked the pancreatic islets up to three weeks and visualized the dumbbell-shape transformation from the single islet. This window can...
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

A Lower Baseline Urinary Glucose Excretion Predicts a Better Response to the Sodium Glucose Cotransporter 2 Inhibitor.
Authors: Hwang YC, Kim JH, Lee BW, Lee WJ Abstract We aimed to identify the clinical variables associated with a better glucose-lowering response to the sodium glucose cotransporter 2 inhibitor ipragliflozin in people with type 2 diabetes mellitus (T2DM). We especially focused on urinary glucose excretion (UGE). This was a single-arm multicenter prospective study. A total of 92 people with T2DM aged 20 to 70 years with glycosylated hemoglobin (HbA1c) levels ≥7.0% and ≤9.5% were enrolled. Ipragliflozin (50 mg) was added to the background therapy for these people for 12 weeks. After 3 months treatment with ipra...
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effectiveness and Safety of Adding Basal Insulin Glargine in Patients with Type 2 Diabetes Mellitus Exhibiting Inadequate Response to Metformin and DPP-4 Inhibitors with or without Sulfonylurea.
CONCLUSION: The combination add-on therapy of insulin glargine, on metformin and DPP-4 inhibitors with or without SU was safe and efficient in reducing HbA1c levels and thus, is a preferable option in managing T2DM patients exhibiting dysglycemia despite the use of OADs. PMID: 31237133 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Authors: Jun JE, Jeong IK, Yu JM, Kim SR, Lee IK, Han KA, Choi SH, Kim SK, Park HK, Mok JO, Lee YH, Kwon HS, Kim SH, Kang HC, Lee SA, Lee CB, Choi KM, Her SH, Shin WY, Shin MS, Ahn HS, Kang SH, Cho JM, Jo SH, Cha TJ, Kim SY, Won KH, Kim DB, Lee JH, Lee MK Abstract BACKGROUND: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and...
Source: Diabetes and Metabolism Journal - June 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Authors: Ferrell JM, Chiang JYL Abstract Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity o...
Source: Diabetes and Metabolism Journal - June 20, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Diabetes Mellitus, Still Major Threat to Mortality from Various Causes.
Authors: Kim NH PMID: 31210035 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 20, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study.
CONCLUSION: The current study's findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer's disease. PMID: 31210036 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 20, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors (Diabetes Metab J 2019;43:158-73).
Authors: Kim KS PMID: 31210037 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 20, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors (Diabetes Metab J 2019;43:158-73).
Authors: Lee JY, Kang ES PMID: 31210038 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 20, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Corrigenda: Omission of the Description of Informed Consent.
Authors: Editorial Office, Diabetes & Metabolism Journal Abstract This corrects the article on p. 519 in vol. 42, PMID: 30398037, This corrects the article on p. 90 in vol. 43, PMID: 30398038. PMID: 31210039 [PubMed - in process] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - June 20, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment.
Authors: Kim KS, Lee BW, Kim YJ, Lee DH, Cha BS, Park CY Abstract Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders that are often comorbid conditions. Among many proposed treatments, weight reduction is the only approved option for NAFLD to date. However, it is not easy to maintain weight loss by lifestyle modification alone; pharmacological treatments are helpful in this regard. Although many drugs have been investigated, pioglitazone could be a first-line therapy in patients with NAFLD and diabetes. Many more drugs are currently being developed and investigated, and it is likel...
Source: Diabetes and Metabolism Journal - April 19, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity.
Authors: Song SO, He K, Narla RR, Kang HG, Ryu HU, Boyko EJ Abstract Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. However, OSA and diabetes have a high prevalence rate in public and shares the common overlap characteristic and risk factors such as age, obesity, and metabolic syndrome that...
Source: Diabetes and Metabolism Journal - April 19, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Simply the Best: Anthropometric Indices for Predicting Cardiovascular Disease.
Authors: Lee JE PMID: 30993939 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 19, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Letter: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90-6).
Authors: Koo BK PMID: 30993940 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 19, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Response: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90-6).
Authors: Baik I PMID: 30993941 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 19, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes.
This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 2,399 male participants of>20 years of age who were euthyroid and non-diabetic. Prediabetic participants had lower FT4 concentrations than those without prediabetes, but their thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, glycosylated he...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Effects of Dapagliflozin on Endothelial Function, Renal Injury Markers, and Glycemic Control in Drug-Na ïve Patients with Type 2 Diabetes Mellitus.
CONCLUSION: Dapagliflozin treatment did not affect systemic endothelial function or renal injury markers except N-acetyl-beta-D-glucosaminidase. PMID: 30968615 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Relation between Baseline Height and New Diabetes Development: A Nationwide Population-Based Study.
Authors: Rhee EJ, Cho JH, Kwon H, Park SE, Jung JH, Han KD, Park YG, Kim YH, Lee WY Abstract BACKGROUND: Short stature and leg length are associated with risk of diabetes and obesity. However, it remains unclear whether this association is observed in Asians. We evaluated the association between short stature and increased risk for diabetes using the Korean National Health Screening (KNHS) dataset. METHODS: We assessed diabetes development in 2015 in 21,122,422 non-diabetic Koreans (mean age 43 years) enrolled in KNHS from 2009 to 2012 using International Classification of Diseases 10th (ICD-10) code and anti-d...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study.
CONCLUSION: There is a positive association between plasma fetuin-A levels and risk of developing T2DM in this Chinese population. PMID: 30968617 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation.
Authors: Woo CY, Jang JE, Lee SE, Koh EH, Lee KU Abstract Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study.
CONCLUSION: Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome. PMID: 30968619 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults.
This study was based on data obtained from the sixth Korea National Health and Nutrition Examination Survey, administered from 2013 to 2015. A total of 13,873 participants aged ≥19 years were included, and classified into four groups: metabolically healthy non-obesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), and metabolically unhealthy obesity (MUO) by body fat on the basis of body mass index and metabolic health. RESULTS: At baseline, serum free thyroxine (fT4) values were significantly higher in the MHNO phenotype (MHNO, 1.27±0.01 ng/mL; MHO, 1.25±0.01 ...
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3.
CONCLUSION: PRMT1 critically contributes to pancreas development by destabilizing the NGN3 protein. PMID: 30968621 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 12, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Protective Effects of Increasing Serum Uric Acid Level on Development of Metabolic Syndrome.
Authors: Yu TY, Jin SM, Jee JH, Bae JC, Lee MK, Kim JH Abstract BACKGROUND: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects. METHODS: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with develop...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus.
CONCLUSION: Taken together, intact incretin levels are primarily related to C-peptide and glucose levels. This result suggests that glycemia and insulin secretion are the main factors associated with intact incretin levels in T2DM patients. PMID: 30877705 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus.
Authors: Huh JH, Ahn SG, Kim YI, Go T, Sung KC, Choi JH, Koh KK, Kim JY Abstract BACKGROUND: Metabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM. METHODS: We analyzed data from 7,317 participants aged 40 to 70 years without DM at baseline, who took part in 2001 to 2011 Korean Genome Epidemiology Study. Subjects were categorized into four groups based on repeated longitudinal assessment of MetS status over ...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study.
CONCLUSION: This population-based cohort study showed that the use of DPP4i as add-on therapy to metformin did not increase the risk of DR progression compared to SU. PMID: 30877707 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus.
CONCLUSIONS: Liver fibrosis was associated with LV diastolic dysfunction in patients with T2DM and may be an independent risk factor for diastolic dysfunction, especially in patients without systemic insulin resistance. PMID: 30877708 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Korean Patients with Type 2 Diabetes Mellitus in Real-World Clinical Practice.
This study aimed to evaluate the efficacy and safety of sodium-glucose cotransporter-2 (SGLT2) inhibitors in Korean patients who had inadequately controlled type 2 diabetes mellitus (T2DM) in real-world clinical practice. METHODS: We included 410 patients who started SGLT2 inhibitors (empagliflozin or dapagliflozin) as add-on therapy or switch therapy between February 2015 and June 2017. The primary efficacy endpoint was a change in glycosylated hemoglobin (HbA1c) from baseline to week 12. The secondary endpoints were patients achieving HbA1c
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests.
Authors: Kang S, Kim MH, Kim MY, Hong JS, Kwak SH, Choi SH, Lim S, Park KS, Jang HC Abstract BACKGROUND: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. METHODS: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) a...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.
CONCLUSION: The present study shows that activation of the NLRP3 inflammasome contributes to UUO-induced renal fibrosis and the renoprotective effect of gemigliptin is associated with attenuation of NLRP3 inflammasome activation. PMID: 30877711 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study.
CONCLUSION: Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings. PMID: 30877712 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria.
Authors: Kim MH, Kwak SH, Kim SH, Hong JS, Chung HR, Choi SH, Kim MY, Jang HC Abstract BACKGROUND: We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by the Carpenter-Coustan (CC) criteria. METHODS: A total of 8,735 Korean pregnant women were identified at two hospitals between 2014 and 2016. Among them, 2,038 women participated in the prospective cohort to investigate pregnancy outcomes. Diagnosis of GDM was made via two-step approach with 50-g glucose c...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Lower Leg Fat Depots Are Associated with Albuminuria Independently of Obesity, Insulin Resistance, and Metabolic Syndrome (Korea National Health and Nutrition Examination Surveys 2008 to 2011).
Authors: Han E, Cho NH, Kim MK, Kim HS Abstract BACKGROUND: Although the involvement of obesity in metabolic disorders is well known, leg fat depot influences on albuminuria have not been determined. METHODS: This population-based, cross-sectional study used a nationally representative sample of 2,076 subjects aged ≥20 years from the Korea National Health and Nutrition Examination Surveys of 2008 to 2011. The ratio of leg fat to total fat (LF/TF ratio) was assessed by dual X-ray absorptiometry, and albuminuria was defined as more than one positive dipstick test or an albumin-to-creatinine ratio of ≥30 mg/...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function.
Authors: Seo DH, Kim SH, Song JH, Hong S, Suh YJ, Ahn SH, Woo JT, Baik SH, Park Y, Lee KW, Kim YS, Nam M, KNDP Study Group Abstract BACKGROUND: Recent evidences indicate that early rapid renal function decline is closely associated with the development and progression of diabetic kidney disease. We have investigated the association between carotid atherosclerosis and rapid renal function decline in patients with type 2 diabetes mellitus and preserved renal function. METHODS: In a prospective, multicenter cohort, a total of 967 patients with type 2 diabetes mellitus and preserved renal function were followed for...
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction?
CONCLUSION: Fasting measurements of glucose and C-peptide as well as the surrogate indices of glycemic condition could be used for stratifying pregnant females with higher risk of GDM at the beginning of pregnancy. PMID: 30877716 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 17, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

DMJ, Better than Yesterday, More Brilliant Tomorrow.
Authors: Won KC PMID: 30793548 [PubMed] (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet.
Authors: Spallone V Abstract The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are on the table: by promoting screening for symptoms and signs; by ...
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis.
Authors: Lee YH, Cho Y, Lee BW, Park CY, Lee DH, Cha BS, Rhee EJ Abstract Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This recip...
Source: Diabetes and Metabolism Journal - February 24, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research