Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity
CONCLUSION: The ASGR1 deficiency was consequentially linked with improved hepatic insulin sensitivity under metabolic stress, hepatic IR was the core factor of systemic IR, and overcoming hepatic IR significantly relieved the systemic IR. It suggests that ASGR1 is a potential intervention target for improving systemic IR in metabolic disorders.PMID:38310881 | DOI:10.4093/dmj.2023.0124 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Xiaorui Yu Jiawang Tao Yuhang Wu Yan Chen Penghui Li Fan Yang Miaoxiu Tang Abdul Sammad Yu Tao Yingying Xu Yin-Xiong Li Source Type: research

Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice
CONCLUSION: This study identified the potential link between decreased CB abundance in gut microbiota and vascular inflammation in diabetes. Therapeutic delivery of CB by gut transplantation alleviates the vascular lesions of diabetes mellitus by activating the Nrf2/HO-1 pathway.PMID:38310882 | DOI:10.4093/dmj.2023.0109 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Tian Zhou Shuo Qiu Liang Zhang Yangni Li Jing Zhang Donghua Shen Ping Zhao Lijun Yuan Lianbi Zhao Yunyou Duan Changyang Xing Source Type: research

Safety and Effectiveness of Dulaglutide in the Treatment of Type 2 Diabetes Mellitus: A Korean Real-World Post-Marketing Study
CONCLUSION: Dulaglutide was generally well tolerated and effective in real-world Korean individuals with T2DM. The results from this study contribute to the body of evidence for dulaglutide use in this population.PMID:38310883 | DOI:10.4093/dmj.2023.0030 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Jeonghee Han Woo Je Lee Kyu Yeon Hur Jae Hyoung Cho Byung Wan Lee Cheol-Young Park Source Type: research

Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
CONCLUSION: PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.PMID:38311057 | DOI:10.4093/dmj.2023.0196 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Ah Reum Khang Dong Hun Kim Min-Ji Kim Chang Joo Oh Jae-Han Jeon Sung Hee Choi In-Kyu Lee Source Type: research

A Composite Blood Biomarker Including AKR1B10 and Cytokeratin 18 for Progressive Types of Nonalcoholic Fatty Liver Disease
CONCLUSION: Our blood composite biomarker can be useful to distinguish progressive forms of NAFLD as an initial noninvasive test when MR-based tools are not available.PMID:38311058 | DOI:10.4093/dmj.2023.0189 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Seung Joon Choi Sungjin Yoon Kyoung-Kon Kim Doojin Kim Hye Eun Lee Kwang Gi Kim Seung Kak Shin Ie Byung Park Seong Min Kim Dae Ho Lee Source Type: research

Clinical Characteristics of Diabetes in People with Mitochondrial DNA 3243A & gt;G Mutation in Korea
Diabetes Metab J. 2024 Feb 1. doi: 10.4093/dmj.2023.0078. Online ahead of print.ABSTRACTMaternally inherited diabetes and deafness (MIDD) is a rare mitochondrial disorder primarily resulting from m.3243A>G mutation. The clinical characteristics of MIDD exhibit significant heterogeneity. Our study aims to delineate these characteristics and determine the potential correlation with m.3243A>G heteroplasmy levels. This retrospective, descriptive study encompassed patients with confirmed m.3243A>G mutation and diabetes mellitus at Seoul National University Hospital. Our cohort comprises 40 patients with MIDD, with a me...
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Eun Hoo Rho Sang Ik Baek Heerah Lee Moon-Woo Seong Jong-Hee Chae Kyong Soo Park Soo Heon Kwak Source Type: research

Comparative Effect of Glucose-Lowering Drugs for Type 2 Diabetes Mellitus on Stroke Prevention: A Systematic Review and Network Meta-Analysis
CONCLUSION: SGLT-2 inhibitors and GLP-1 agonists were shown to be beneficial for stroke prevention in patients with type 2 diabetes mellitus.PMID:38273787 | DOI:10.4093/dmj.2022.0421 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Ji Soo Kim Gyeongsil Lee Kyung-Il Park Seung-Won Oh Source Type: research

Risk Prediction and Management of Chronic Kidney Disease in People Living with Type 2 Diabetes Mellitus
Diabetes Metab J. 2024 Jan 26. doi: 10.4093/dmj.2023.0244. Online ahead of print.ABSTRACTPeople with type 2 diabetes mellitus have increased risk of chronic kidney disease and atherosclerotic cardiovascular disease. Improved care delivery and implementation of guideline-directed medical therapy have contributed to the declining incidence of atherosclerotic cardiovascular disease in high-income countries. By contrast, the global incidence of chronic kidney disease and associated mortality is either plateaued or increased, leading to escalating direct and indirect medical costs. Given limited resources, better risk stratific...
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Ying-Guat Ooi Tharsini Sarvanandan Nicholas Ken Yoong Hee Quan-Hziung Lim Sharmila S Paramasivam Jeyakantha Ratnasingam Shireene R Vethakkan Soo-Kun Lim Lee-Ling Lim Source Type: research

Role of Fenofibrate Use in Dyslipidemia and Related Comorbidities in the Asian Population: A Narrative Review
Diabetes Metab J. 2024 Jan 26. doi: 10.4093/dmj.2023.0168. Online ahead of print.ABSTRACTHypertriglyceridemia and decreased high-density lipoprotein cholesterol (HDL-C) persist despite statin therapy, contributing to residual atherosclerotic cardiovascular disease (ASCVD) risk. Asian subjects are metabolically more susceptible to hypertriglyceridemia than other ethnicities. Fenofibrate regulates hypertriglyceridemia, raises HDL-C levels, and is a recommended treatment for dyslipidemia. However, data on fenofibrate use across different Asian regions are limited. This narrative review summarizes the efficacy and safety data ...
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Chaicharn Deerochanawong Sin Gon Kim Yu-Cheng Chang Source Type: research

Abrupt Decline in Estimated Glomerular Filtration Rate after Initiating Sodium-Glucose Cotransporter 2 Inhibitors Predicts Clinical Outcomes: A Systematic Review and Meta-Analysis
CONCLUSION: Initial eGFR dip after initiating SGLT2i might be associated with less annual eGFR decline. There were no significant disparities in the risks of adverse cardiovascular outcomes between the dipping and non-dipping groups.PMID:38273790 | DOI:10.4093/dmj.2023.0201 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Min-Hsiang Chuang Yu-Shuo Tang Jui-Yi Chen Heng-Chih Pan Hung-Wei Liao Wen-Kai Chu Chung-Yi Cheng Vin-Cent Wu Michael Heung Source Type: research

Two-Year Therapeutic Efficacy and Safety of Initial Triple Combination of Metformin, Sitagliptin, and Empagliflozin in Drug-Na ïve Type 2 Diabetes Mellitus Patients
CONCLUSION: Initial triple combination therapy with metformin, sitagliptin, and empagliflozin led to achievement of the glycemic target goal, which was maintained for 24 months without severe hypoglycemia but with improved metabolic function and albuminuria. This combination therapy may be a good strategy for drug-naïve patients with type 2 diabetes mellitus.PMID:38273791 | DOI:10.4093/dmj.2023.0128 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Young-Hwan Park Minji Sohn So Yeon Lee Soo Lim Source Type: research

Hepatic Fibrosis and Cancer: The Silent Threats of Metabolic Syndrome
Diabetes Metab J. 2024 Jan 26. doi: 10.4093/dmj.2023.0240. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic (fatty) liver disease (MASLD), previously termed non-alcoholic fatty liver disease, is a worldwide epidemic that can lead to hepatic inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The disease is typically a component of the metabolic syndrome that accompanies obesity, and is often overlooked because the liver manifestations are clinically silent until late-stage disease is present (i.e., cirrhosis). Moreover, Asian populations, including Koreans, have a higher fraction ...
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Scott L Friedman Source Type: research

Real-World Treatment Patterns according to Clinical Practice Guidelines in Patients with Type 2 Diabetes Mellitus and Established Cardiovascular Disease in Korea: Multicenter, Retrospective, Observational Study
CONCLUSION: The SGLT2i or GLP-1RA prescription rates were suboptimal in patients with T2DM and established CVD. Sex, body mass index, diabetes duration, glycemic control, and renal function were associated with the use of these agents.PMID:38273793 | DOI:10.4093/dmj.2023.0225 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 26, 2024 Category: Endocrinology Authors: Ye Seul Yang Nam Hoon Kim Jong Ha Baek Seung-Hyun Ko Jang Won Son Seung-Hwan Lee Sang Youl Rhee Soo-Kyung Kim Tae Seo Sohn Ji Eun Jun In-Kyung Jeong Chong Hwa Kim Keeho Song Eun-Jung Rhee Junghyun Noh Kyu Yeon Hur Committee of Clinical Practice Guidelines Source Type: research

Alantolactone Attenuates Renal Fibrosis via Inhibition of Transforming Growth Factor β/Smad3 Signaling Pathway
CONCLUSION: Alantolactone improves renal fibrosis by inhibiting the TGF-β/Smad3 signaling pathway in obstructive nephropathy. Thus, alantolactone is a potential therapeutic agent for chronic kidney disease.PMID:38173367 | PMC:PMC10850280 | DOI:10.4093/dmj.2022.0231 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Kyeong-Min Lee Yeo Jin Hwang Gwon-Soo Jung Source Type: research

Association of Muscle Mass Loss with Diabetes Development in Liver Transplantation Recipients
CONCLUSION: Muscle depletion after liver transplantation is associated with increased risk of PTDM development.PMID:38173368 | PMC:PMC10850281 | DOI:10.4093/dmj.2022.0100 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - January 4, 2024 Category: Endocrinology Authors: Sejeong Lee Minyoung Lee Young-Eun Kim Hae Kyung Kim Sook Jung Lee Jiwon Kim Yurim Yang Chul Hoon Kim Hyangkyu Lee Dong Jin Joo Myoung Soo Kim Eun Seok Kang Source Type: research