Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases
Diabetes Metab J. 2024 Feb 15. doi: 10.4093/dmj.2023.0213. Online ahead of print.ABSTRACTSeveral mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial dynamics disorders. Mitophagy, specialized autophagy, is responsible for clearing dysfunctional mitochondria in physiological and pathological conditions. As a paradox, inhibition and activation of mitophagy have been observed in obesity and diabetes-related heart disorders, with both exert...
Source: Diabetes and Metabolism Journal - February 15, 2024 Category: Endocrinology Authors: Songling Tang Di Hao Wen Ma Lian Liu Jiuyu Gao Peng Yao Haifang Yu Lu Gan Yu Cao Source Type: research
Combining Ezetimibe and Rosuvastatin: Impacts on Insulin Sensitivity and Vascular Inflammation in Patients with Type 2 Diabetes Mellitus
Diabetes Metab J. 2024 Jan;48(1):55-58. doi: 10.4093/dmj.2023.0442. Epub 2024 Jan 29.NO ABSTRACTPMID:38317513 | PMC:PMC10850279 | DOI:10.4093/dmj.2023.0442 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 6, 2024 Category: Endocrinology Authors: Eun Roh Source Type: research
Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition (Diabetes Metab J 2023;47:784-95)
Diabetes Metab J. 2024 Jan;48(1):157-158. doi: 10.4093/dmj.2022.0430. Epub 2024 Jan 29.NO ABSTRACTPMID:38317514 | PMC:PMC10850278 | DOI:10.4093/dmj.2022.0430 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 6, 2024 Category: Endocrinology Authors: Jae Hyun Bae Source Type: research
Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition (Diabetes Metab J 2023;47:784-95)
Diabetes Metab J. 2024 Jan;48(1):159-160. doi: 10.4093/dmj.2022.0458. Epub 2024 Jan 29.NO ABSTRACTPMID:38317515 | PMC:PMC10850274 | DOI:10.4093/dmj.2022.0458 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 6, 2024 Category: Endocrinology Authors: Ho Gyun Lee Il Hyeon Jung Byong Seo Park Hye Rim Yang Kwang Kon Kim Thai Hien Tu Jung-Yong Yeh Sewon Lee Sunggu Yang Byung Ju Lee Jae Geun Kim Il Seong Nam-Goong Source Type: research
Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
Diabetes Metab J. 2024 Feb 2. doi: 10.4093/dmj.2023.0350. Online ahead of print.ABSTRACTIt has been generally accepted that insulin resistance (IR) and reduced insulin secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, the persistence of systemic inflammation caused by obesity and the associated threat of lipotoxicity increase the risk of T2DM. In particular, the main cause of IR is obesity and subjects with T2DM have a higher body mass index (BMI) than normal subjects according to recent studies. The prevalence of T2DM with IR has increased with increasing BMI...
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Inha Jung Dae-Jeong Koo Won-Young Lee Source Type: research
Associations of Ultra-Processed Food Intake with Body Fat and Skeletal Muscle Mass by Sociodemographic Factors
CONCLUSION: A higher UPF intake was associated with higher adiposity and lower skeletal muscle mass among Korean adults aged 40 years and older, particularly in those from rural areas and with lower education levels.PMID:38310874 | DOI:10.4093/dmj.2023.0335 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Sukyoung Jung Jaehee Seo Jee Young Kim Sohyun Park Source Type: research
Pioglitazone as Add-on THERAPY in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial
CONCLUSION: Triple therapy with the addition of 15 mg/day of pioglitazone to dapagliflozin plus metformin was well tolerated and produced significant improvements in HbA1c in patients with T2DM inadequately controlled with dapagliflozin plus metformin.PMID:38310875 | DOI:10.4093/dmj.2023.0314 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 4, 2024 Category: Endocrinology Authors: Ji Hye Heo Kyung Ah Han Jun Hwa Hong Hyun-Ae Seo Eun-Gyoung Hong Jae Myung Yu Hye Seung Jung Bong-Soo Cha Source Type: research
