One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus
Diabetes Metab J. 2024 Mar 12. doi: 10.4093/dmj.2023.0272. Online ahead of print.ABSTRACTDiabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance. HHcy can result from low status of one-carbon metabolism (OCM) nutrients (e.g., folate, choline, betaine, vitamin B6, B12), which work together to degrade homocysteine by methylation. The etiology of HHcy may also involve genetic variation encoding key enzymes in OCM. This review aimed to provide an overvi...
Source: Diabetes and Metabolism Journal - March 12, 2024 Category: Endocrinology Authors: Jie Zhu Gunjana Saikia Xiaotao Zhang Xiaoxi Shen Ka Kahe Source Type: research
A Prospective 1-Year Follow-Up of Glycemic Status and C-Peptide Levels of COVID-19 Survivors with Dysglycemia in Acute COVID-19 Infection
CONCLUSION: Subjects who had dysglycemia in acute COVID-19 were characterized by insulin resistance. Over 1 year, a quarter had progression in glycemic status, especially those with more severe COVID-19. Importantly, there was no significant deterioration in insulin secretory capacity.PMID:38467385 | DOI:10.4093/dmj.2023.0175 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - March 11, 2024 Category: Endocrinology Authors: David Tak Wai Lui Chi Ho Lee Ying Wong Carol Ho Yi Fong Kimberly Hang Tsoi Yu Cho Woo Kathryn Choon Beng Tan Source Type: research
Switching from Conventional Fibrates to Pemafibrate Has Beneficial Effects on the Renal Function of Diabetic Subjects with Chronic Kidney Disease
CONCLUSION: A switch to pemafibrate may be associated with an elevation in eGFR, but to a lesser extent in patients with poor renal function.PMID:38419467 | DOI:10.4093/dmj.2023.0370 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 29, 2024 Category: Endocrinology Authors: Rimi Izumihara Hiroshi Nomoto Kenichi Kito Yuki Yamauchi Kazuno Omori Yui Shibayama Shingo Yanagiya Aika Miya Hiraku Kameda Kyu Yong Cho So Nagai Ichiro Sakuma Akinobu Nakamura Tatsuya Atsumi PARM-T2D Study Group Source Type: research
Efficacy and Safety of IDegAsp in a Real-World Korean Population with Type 2 Diabetes Mellitus
CONCLUSION: In real-world clinical practice in Korea, the change of insulin regimen to IDegAsp was associated with an improvement in glycemic control without increase of hypoglycemia, supporting the use of IDegAsp for patients with T2DM uncontrolled with basal or premix insulin.PMID:38410023 | DOI:10.4093/dmj.2023.0297 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 27, 2024 Category: Endocrinology Authors: Shinae Kang Yu-Bae Ahn Tae Keun Oh Won-Young Lee Sung Wan Chun Boram Bae Amine Dahaoui Jin Sook Jeong Sungeun Jung Hak Chul Jang Source Type: research
Does the Relationship of the Autonomic Symptoms Questionnaire COMPASS 31 with Cardiovascular Autonomic Tests Differ between Type 1 and Type 2 Diabetes Mellitus?
CONCLUSION: COMPASS 31 is more weakly related to CAN in T2DM than in T1DM, with a fair diagnostic accuracy for confirmed CAN only in T1DM. This difference supports a multifactorial origin of symptoms and should be considered when using COMPASS 31.PMID:38408489 | DOI:10.4093/dmj.2023.0301 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 26, 2024 Category: Endocrinology Authors: Ilenia D'Ippolito Marika Menduni Cinzia D'Amato Aikaterini Andreadi Davide Lauro Vincenza Spallone Source Type: research
